Thbd

Summary

Gene Symbol: Thbd
Description: thrombomodulin
Alias: thrombomdulin
Species: rat

Top Publications

  1. ncbi Molecular cloning and sequence analysis of the 5'-flanking region of the Sprague-Dawley rat thrombomodulin gene
    A Yao
    Department of Pathology, University of Arkansas for Medical Sciences, Little Rock 72205, USA
    DNA Seq 10:55-60. 1999
  2. ncbi Increased immunohistochemical expression of thrombomodulin at placental perivascular myofibroblast in severe preeclampsia (PE)
    C Bosco
    Anatomy and Development Biology Program, Molecular and Clinical Pharmacology Program and Pathology Program, ICBM Faculty of Medicine, University of Chile, Santiago
    Histol Histopathol 20:1045-55. 2005
  3. doi Expression of the endothelial thrombomodulin (TM) on the ischemic rat flap model: preliminary study
    Fatih Uygur
    Department of Plastic and Reconstructive Surgery and Burn Unit, Gulhane Military Medical Academy, Haydarpasha Training Hospital, Selimiye Mahallesi Tibbiye Caddesi 34 668, Uskudar, Istanbul, Turkey
    Ann Plast Surg 62:693-8. 2009
  4. pmc An Akt- and Fra-1-dependent pathway mediates platelet-derived growth factor-induced expression of thrombomodulin, a novel regulator of smooth muscle cell migration
    Aruna Ramachandran
    Urological Diseases Research Center, John F Enders Research Laboratories, Room 1077, Children s Hospital Boston, 300 Longwood Ave, Boston, MA 02115, USA
    Am J Pathol 177:119-31. 2010
  5. doi Recombinant thrombomodulin prevents heatstroke by inhibition of high-mobility group box 1 protein in sera of rats
    Satoshi Hagiwara
    Department of Anesthesiology and Intensive Care Medicine, Oita University Faculty of Medicine, Yufu City, Oita, Japan
    Shock 34:402-6. 2010
  6. pmc Deficiency of microvascular thrombomodulin and up-regulation of protease-activated receptor-1 in irradiated rat intestine: possible link between endothelial dysfunction and chronic radiation fibrosis
    Junru Wang
    Department of Surgery, University of Arkansas for Medical Sciences and Central Arkansas Veterans Healthcare System, Little Rock, Arkansas 72205, USA
    Am J Pathol 160:2063-72. 2002
  7. doi Recombinant human soluble thrombomodulin decreases the plasma high-mobility group box-1 protein levels, whereas improving the acute liver injury and survival rates in experimental endotoxemia
    Masaru Nagato
    Department of Surgery 1, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan
    Crit Care Med 37:2181-6. 2009
  8. doi Neuropathologic evidence of endothelial changes in cerebral small vessel disease
    M O Giwa
    Stroke and Dementia Research Centre, St Georges University of London, London, UK
    Neurology 78:167-74. 2012
  9. pmc Clinical implications of serum thrombomodulin in PR3-ANCA-associated vasculitis
    K Zycinska
    Primary Systemic Vasculitis Outpatient Clinic, Department of Family Medicine, Internal and Metabolic Diseases, Warsaw Medical University, Warsaw, Poland
    Eur J Med Res 14:268-70. 2009
  10. ncbi Clinical significance of selected endothelial activation markers in patients with systemic lupus erythematosus
    Anna Kuryliszyn-Moskal
    Department of Rheumatology and Internal Diseases, Medical University of Bialystok, Bialystok, Poland
    J Rheumatol 35:1307-13. 2008

Scientific Experts

Detail Information

Publications65

  1. ncbi Molecular cloning and sequence analysis of the 5'-flanking region of the Sprague-Dawley rat thrombomodulin gene
    A Yao
    Department of Pathology, University of Arkansas for Medical Sciences, Little Rock 72205, USA
    DNA Seq 10:55-60. 1999
    ..The rat thrombomodulin gene promoter sequence shows 89% homology to that of mouse and 77% homology to that of human...
  2. ncbi Increased immunohistochemical expression of thrombomodulin at placental perivascular myofibroblast in severe preeclampsia (PE)
    C Bosco
    Anatomy and Development Biology Program, Molecular and Clinical Pharmacology Program and Pathology Program, ICBM Faculty of Medicine, University of Chile, Santiago
    Histol Histopathol 20:1045-55. 2005
    ....
  3. doi Expression of the endothelial thrombomodulin (TM) on the ischemic rat flap model: preliminary study
    Fatih Uygur
    Department of Plastic and Reconstructive Surgery and Burn Unit, Gulhane Military Medical Academy, Haydarpasha Training Hospital, Selimiye Mahallesi Tibbiye Caddesi 34 668, Uskudar, Istanbul, Turkey
    Ann Plast Surg 62:693-8. 2009
    ..TM depletion from the vascular cells and microthrombus formation occurred in the ischemic areas, playing an important role in secondary aggravation of tissue ischemia...
  4. pmc An Akt- and Fra-1-dependent pathway mediates platelet-derived growth factor-induced expression of thrombomodulin, a novel regulator of smooth muscle cell migration
    Aruna Ramachandran
    Urological Diseases Research Center, John F Enders Research Laboratories, Room 1077, Children s Hospital Boston, 300 Longwood Ave, Boston, MA 02115, USA
    Am J Pathol 177:119-31. 2010
    ..Moreover, TM induction on bladder injury suggests that it may be a biomarker for pathological smooth muscle remodeling...
  5. doi Recombinant thrombomodulin prevents heatstroke by inhibition of high-mobility group box 1 protein in sera of rats
    Satoshi Hagiwara
    Department of Anesthesiology and Intensive Care Medicine, Oita University Faculty of Medicine, Yufu City, Oita, Japan
    Shock 34:402-6. 2010
    ..As TM exhibited a strong anti-inflammatory effect in a rat model of acute inflammation induced by heat stress, TM represents a potential therapeutic for heatstroke prevention or management in patients...
  6. pmc Deficiency of microvascular thrombomodulin and up-regulation of protease-activated receptor-1 in irradiated rat intestine: possible link between endothelial dysfunction and chronic radiation fibrosis
    Junru Wang
    Department of Surgery, University of Arkansas for Medical Sciences and Central Arkansas Veterans Healthcare System, Little Rock, Arkansas 72205, USA
    Am J Pathol 160:2063-72. 2002
    ..Interventions aimed at preserving or restoring endothelial TM or blocking PAR-1 should be explored as strategies to increase the therapeutic ratio in clinical radiation therapy...
  7. doi Recombinant human soluble thrombomodulin decreases the plasma high-mobility group box-1 protein levels, whereas improving the acute liver injury and survival rates in experimental endotoxemia
    Masaru Nagato
    Department of Surgery 1, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan
    Crit Care Med 37:2181-6. 2009
    ..Therefore, the therapeutic efficacy of recombinant human soluble thrombomodulin (ART-123) administration on the production of inflammatory cytokines and the plasma level of HMGB1 was investigated in experimental endotoxemia...
  8. doi Neuropathologic evidence of endothelial changes in cerebral small vessel disease
    M O Giwa
    Stroke and Dementia Research Centre, St Georges University of London, London, UK
    Neurology 78:167-74. 2012
    ..In this case-control study, we tested whether brain endothelial ICAM1, thrombomodulin, and IL-6 are altered in SVD...
  9. pmc Clinical implications of serum thrombomodulin in PR3-ANCA-associated vasculitis
    K Zycinska
    Primary Systemic Vasculitis Outpatient Clinic, Department of Family Medicine, Internal and Metabolic Diseases, Warsaw Medical University, Warsaw, Poland
    Eur J Med Res 14:268-70. 2009
    ..Vascular injury is the main mechanism in pathophysiology of PR3-ANCA-associated vasculitis. Soluble serum thrombomodulin (sTM) is a membrane-bound receptor for thrombin expressed by vascular endothelial cells. -..
  10. ncbi Clinical significance of selected endothelial activation markers in patients with systemic lupus erythematosus
    Anna Kuryliszyn-Moskal
    Department of Rheumatology and Internal Diseases, Medical University of Bialystok, Bialystok, Poland
    J Rheumatol 35:1307-13. 2008
    ..We investigated selected endothelial cell activation markers in serum of patients with SLE and their relationships with systemic organ manifestations and disease activity...
  11. ncbi Markers of endothelial cell activation in elderly men at high risk for coronary heart disease
    E M Hjerkinn
    Centre for Clinical Research, Ullevaal University Hospital, Oslo, Norway
    Scand J Clin Lab Invest 65:201-9. 2005
    ..In the haemostatic system, elevated levels of thrombomodulin (TM), von Willebrand factor (vWF) and tissue-type plasminogen activator antigen (tPAag) have likewise been associated with atherothrombotic cardiovascular disease states...
  12. ncbi Cholinesterase inhibitors exert a protective effect on endothelial damage in Alzheimer disease patients
    Barbara Borroni
    Department of Medical Sciences, Neurological Clinic, University of Brescia, Italy
    J Neurol Sci 229:211-3. 2005
    ..05) and sE-sel (p<0.05) values towards the normal range was observed. These findings suggest that endothelial-related ChEIs action might contribute to the clinical efficacy in AD, slowing down pathology progression...
  13. ncbi [Expression of thrombomodulin, endothelial protein C receptor in lung tissue of acute paraquat poisoned rats and intervention of sodium dimercaptopropane sulfonate]
    Zhong qiu Lu
    Emergency Medical Department, The First Affiliated Hospital, Wenzhou Medical College, Wenzhou 325000, China
    Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 27:453-6. 2009
    ..To observe the expression and effect of thrombomodulin (TM) mRNA and endothelial protein C receptor (EPCR) mRNA in lung tissue of acute paraquat poisoned rats, and intervention of sodium dimercaptopropane sulfonate (Na-DMPS)...
  14. ncbi The lectin-like domain of thrombomodulin interferes with complement activation and protects against arthritis
    M Van de Wouwer
    Center for Transgene Technology and Gene Therapy, University of Leuven, Leuven, Belgium
    J Thromb Haemost 4:1813-24. 2006
    ..We previously reported that by mediating signals that interfere with mitogen-activated protein kinase and nuclear factor kappaB pathways, the amino-terminal C-type lectin-like domain of TM has direct anti-inflammatory properties...
  15. doi In vivo and in vitro effects of the anticoagulant, thrombomodulin, on the inflammatory response in rodent models
    Satoshi Hagiwara
    Department of Anesthesiology and Intensive Care Medicine, Faculty of Medicine, Oita University, 1 1 Idaigaoka Hasamamachi Yufu, Oita City, 879 5593, Japan
    Shock 33:282-8. 2010
    ..Given these results, rTM is a strong candidate as a therapeutic agent for various systemic inflammatory diseases...
  16. ncbi Circulating thrombomodulin levels in familial Mediterranean fever
    Z Ozbalkan
    Hacettepe University School of Medicine, Internal Medicine Department, Section of Rheumatology, Ankara Turkey
    Clin Exp Rheumatol 24:S95-8. 2006
    ..This study disclosed for the first time significantly higher increments in the circulating levels of thrombomodulin in FMF. This observation could be a consequence of injured endothelium and/or activated inflammatory cells...
  17. pmc Anchoring fusion thrombomodulin to the endothelial lumen protects against injury-induced lung thrombosis and inflammation
    Bi Sen Ding
    Department of Pharmacology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Am J Respir Crit Care Med 180:247-56. 2009
    ..Diverse forms of pulmonary and vascular injury are accompanied by down-regulation of TM, which aggravates tissue injury. We postulated that anchoring TM to the endothelial surface would restore its protective functions...
  18. pmc Soluble thrombomodulin protects ischemic kidneys
    Asif A Sharfuddin
    Division of Nephrology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA
    J Am Soc Nephrol 20:524-34. 2009
    ..By using an sTM variant, we also determined that the protective effects of sTM were independent of its ability to generate activated protein C. These data suggest that sTM may have therapeutic potential for ischemic AKI...
  19. pmc Crucial role of the protein C pathway in governing microvascular inflammation in inflammatory bowel disease
    Franco Scaldaferri
    Division of Gastroenterology, Istituto di Ricovero e Cura a Carattere Scientifico Istituto Clinico Humanitas, Rozzano, Italy
    J Clin Invest 117:1951-60. 2007
    ..Restoring the PC pathway may represent a new therapeutic approach to suppress intestinal inflammation in IBD...
  20. ncbi Intrarenal administration of recombinant human soluble thrombomodulin ameliorates ischaemic acute renal failure
    Takenori Ozaki
    Department of Nephrology, Nagoya University Graduate School of Medicine, Showaku, Nagoya, Japan 466 8550, Japan
    Nephrol Dial Transplant 23:110-9. 2008
    ..The present study was performed to investigate the effects of recombinant human soluble TM (RHS-TM) on ischaemia/reperfusion (I/R) renal injury...
  21. ncbi Cerebral endothelial injury in elderly patients with severe head injury measured by serum thrombomodulin and von Willebrand factor
    Hiroyuki Yokota
    Department of Emergency and Critical Care Medicine, Main Hospital, Nippon Medical School, Tokyo, Japan
    Neurol Med Chir (Tokyo) 47:383-8; discussion 388. 2007
    ....
  22. ncbi Decrease in circulating endothelial cell adhesion molecule and thrombomodulin levels during oral iloprost treatment in rheumatoid arthritis patients: preliminary results
    Michael W J Boehme
    Dep of Internal Medicine IV, University of Heidelberg, Bergheimer Str 58, D 69115 Heidelberg, Germany
    Rheumatol Int 26:340-7. 2006
    ....
  23. pmc Thrombomodulin Ala455Val Polymorphism and the risk of cerebral infarction in a biracial population: the Stroke Prevention in Young Women Study
    John W Cole
    Department of Neurology, University of Maryland School of Medicine, Baltimore, Maryland, USA
    BMC Neurol 4:21. 2004
    ..Using data from the Stroke Prevention in Young Women Study, we sought to determine the association between the Ala455Val thrombomodulin polymorphism and the occurrence of ischemic stroke in young women...
  24. pmc Age-dependent vulnerability to endotoxemia is associated with reduction of anticoagulant factors activated protein C and thrombomodulin
    Marlene E Starr
    Department of Surgery, University of Texas Medical Branch, Galveston, USA
    Blood 115:4886-93. 2010
    ..These results demonstrate that PC pathway activation is suppressed with aging and is partly responsible for age-associated thrombosis and high mortality during endotoxemia...
  25. pmc Soluble thrombomodulin reduces inflammation and prevents microalbuminuria induced by chronic endothelial activation in transgenic mice
    Gangaraju Rajashekhar
    Indiana Center for Vascular Biology and Medicine, IU School of Medicine, 975 W Walnut St, Med Lib Rm IB442B, Indianapolis, IN 46202, USA
    Am J Physiol Renal Physiol 302:F703-12. 2012
    ....
  26. pmc Human thrombomodulin knock-in mice reveal differential effects of human thrombomodulin on thrombosis and atherosclerosis
    Thomas J Raife
    Department of Pathology, University of Iowa Carver College of Medicine, Iowa City, IA, USA
    Arterioscler Thromb Vasc Biol 31:2509-17. 2011
    ..We sought to develop a murine model to examine the antithrombotic and antiinflammatory functions of human thrombomodulin in vivo...
  27. doi Upregulation of inflammatory mediators in end-stage renal disease as measured using biochip array technology
    Rachael Davis
    Loyola University Medical Center, Maywood, IL, USA
    Clin Appl Thromb Hemost 17:E218-23. 2011
    ..This study further validates the role of endothelial damage and endogenous thrombotic processes in ESRD as evidenced by the increased levels of TM and DD...
  28. pmc Inflammation, TNFα and endothelial dysfunction link lenalidomide to venous thrombosis in chronic lymphocytic leukemia
    Georg Aue
    Hematology Branch, NHLBI, NIH, Bethesda, Maryland 20892 1202, USA
    Am J Hematol 86:835-40. 2011
    ..65, p < 0.001). These data link lenalidomide associated DVTs with TNFα upregulation and endothelial cell dysfunction and suggest that aspirin may have a role for DVT prophylaxis in these patients...
  29. pmc The thrombomodulin analog Solulin promotes reperfusion and reduces infarct volume in a thrombotic stroke model
    E J Su
    Department of Internal Medicine Howard Hughes Medical Institute, University of Michigan Medical School, Ann Arbor, MI 48109 5644, USA
    J Thromb Haemost 9:1174-82. 2011
    ..Solulin is a soluble analog of the endothelial cell receptor thrombomodulin, able to bind free thrombin and convert it to an activator of the anticoagulant, protein C...
  30. pmc Treatment effects of recombinant human soluble thrombomodulin in patients with severe sepsis: a historical control study
    Kazuma Yamakawa
    Department of Emergency and Critical Care, Osaka General Medical Center, 3 1 56 Bandai Higashi, Sumiyoshi ku, Osaka, Japan
    Crit Care 15:R123. 2011
    ..The purpose of this study was to examine the efficacy of rhTM for treating patients with sepsis-induced disseminated intravascular coagulation (DIC)...
  31. doi Endothelial expression of transcription factor Kruppel-like factor 2 and its vasoprotective target genes in the normal and cirrhotic rat liver
    Jorge Gracia-Sancho
    Hepatic Hemodynamic Laboratory, Liver Unit, Hospital Clinic i Provincial, Barcelona, Spain
    Gut 60:517-24. 2011
    ..This study aimed to assess whether abnormal intrahepatic haemodynamics in cirrhosis could modify KLF2 expression and consequently its downstream transcriptional programmes...
  32. doi Evaluation of various endothelial biomarkers in ankylosing spondylitis
    Ali Taylan
    Department of Rheumatology, Izmir Tepecik Training and Research Hospital, Izmir, Turkey
    Clin Rheumatol 31:23-8. 2012
    ..The increased UT-II, sTM, and vWF in AS patient sera regardless of treatment and disease activity suggest an increased tendency for atherosclerosis...
  33. ncbi Reduction expression of thrombomodulin and endothelial cell nitric oxide synthase in dermatomyositis
    Guang li Shen
    Department of Neurology, Peking University First Hospital, Beijing, China
    Neuropathology 27:309-13. 2007
    ..The low expression of TM and eNOS in microvessels suggests the anticoagulation and vasodilation functions of vascular endothelium is reduced. DM is an inflammatory vascular endothelial disease...
  34. pmc Plasma biomarker profiles in acute exacerbation of idiopathic pulmonary fibrosis
    Harold R Collard
    Department of Medicine, University of California San Francisco, San Francisco, California, USA
    Am J Physiol Lung Cell Mol Physiol 299:L3-7. 2010
    ..Furthermore, they suggest that acute exacerbation of IPF has a distinct plasma biomarker profile from that of acute lung injury...
  35. ncbi Serum thrombomodulin in systemic lupus erythematosus and juvenile idiopathic arthritis
    Yehia M el-Gamal
    Department of Pediatrics, Faculty of Medicine, Ain Shams University, Cairo, Egypt
    Pediatr Allergy Immunol 15:270-7. 2004
    ..Serum sTM is a useful serologic marker of disease activity in SLE and JIA. It may prove to be a potential indicator for early and more aggressive treatment. Furthermore, sTM may prove to be an important marker for vasculitis in general...
  36. ncbi Enhanced production of endothelial microparticles with increased binding to leukocytes in patients with severe systemic inflammatory response syndrome
    Hiroshi Ogura
    Department of Traumatology, Osaka University Medical School, Suita City, Osaka, Japan
    J Trauma 56:823-30; discussion 830-1. 2004
    ..The objective of this study was to evaluate endothelial microparticle formation and microparticle-leukocyte interaction among patients with severe systemic inflammatory response syndrome (SIRS)...
  37. ncbi Thrombomodulin and antibeta2-glycoprotein I in stroke in children
    Ewa Pilarska
    Department of Developmental Neurology, Medical University of Gdansk, Gdansk, Poland
    Med Sci Monit 16:CR348-51. 2010
    ..Little is known about the problem in children. The aim of the study was to see if there is a difference in the values of Thm and beta2-GPI in children with ischemic stroke...
  38. doi Decreased expression of thrombomodulin is correlated with tumor cell invasiveness and poor prognosis in nonsmall cell lung cancer
    Po Len Liu
    Department of Respiratory Therapy, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
    Mol Carcinog 49:874-81. 2010
    ..This study demonstrates that a decrease in TM expression may be an indicator in the prognosis of NSCLC patients and provides new insights into the molecular mechanisms of TM in the metastasis of NSCLC...
  39. doi Inhibition of allergic bronchial asthma by thrombomodulin is mediated by dendritic cells
    Takehiro Takagi
    Department of Immunology, Mie University School of Medicine, Edobashi 2 174, Tsu City, Mie Prefecture 514 8507, Japan
    Am J Respir Crit Care Med 183:31-42. 2011
    ..bronchial asthma is caused by inappropriate acquired immune responses to environmental allergens. It is a major health problem, with a prevalence that is rapidly increasing. Curative therapy is not currently available...
  40. doi Activated protein C improves the severity of severe acute pancreatitis via up-regulating the expressions of endothelial cell protein C receptor and thrombomodulin
    Chen Ping
    Department of Gastroenterology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China
    Dig Dis Sci 55:1599-609. 2010
    ..The aim of this study was to demonstrate the effects of APC on expressions of thrombomodulin (TM) and endothelial cell protein C receptor (EPCR), and its subsequent effect on the severity of SAP...
  41. ncbi Hypertension associated with reduced plasma thrombomodulin levels and a hypercoagulable state in rats
    Kazuyoshi Sawada
    Institute of Bio active Science, Nippon Zoki Pharmaceutical Co, Ltd, Kinashi, Yashiro cho, Kato Gun, Hyogo, Japan
    Clin Exp Hypertens 25:73-84. 2003
    ..These results suggest that hypertension may decrease plasma TM levels and induce a hypercoagulable state in rats...
  42. ncbi [Effects of Xuebijing injection on thrombomodulin and endothelial cell protein C receptor in septic rats]
    Yin Ping Li
    Tianjin Tianhe Hospital, Tianjin 300050, China
    Zhongguo Wei Zhong Bing Ji Jiu Yi Xue 19:365-8. 2007
    ..To investigate effects of the integrated traditional Chinese medicine Xuebijing injection on thrombomodulin (TM) and endothelial cell protein C receptor (EPCR) in septic rats...
  43. ncbi Impact of alpha-tocopherol and vitamin C on endothelial markers in rats with streptozotocin-induced diabetes
    Mohamed A Haidara
    Department of Physiology, Kasr Al Aini Faculty of Medicine, Cairo University, Cairo, Egypt
    Med Sci Monit 10:BR41-6. 2004
    ..Plasma soluble thrombomodulin (sTM) and von Willebrand factor (vWF) have been found to be important markers of endothelial dysfunction...
  44. ncbi Thrombomodulin and tissue factor pathway inhibitor in endocardium of rapidly paced rat atria
    Takeshi Yamashita
    The Cardiovascular Institute, Roppongi 7 3 10, Minato ku, Tokyo 106 0032, Japan
    Circulation 108:2450-2. 2003
    ....
  45. ncbi The protein C pathway
    Charles T Esmon
    Howard Hughes Medical Institute, Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA
    Chest 124:26S-32S. 2003
    ..APC has been shown clinically to protect patients with severe sepsis. Protein C and thrombomodulin are in early stage clinical trials for this disease, and each has distinct potential advantages and disadvantages relative to APC...
  46. ncbi Alterations in endothelial thrombomodulin expression in zymosan-induced lung injury
    John B Cone
    Department of Surgery, University of Arkansas for Medical Sciences, Central Arkansas Veterans Healthcare System, Little Rock 72205, USA
    J Trauma 54:731-6; discussion 736. 2003
    ..This study assessed the changes in lung tissue endothelial thrombomodulin (TM) expression in a rat model of zymosan-induced remote lung injury...
  47. ncbi Bacterial lipopolysaccharide decreases thrombomodulin expression in the sinusoidal endothelial cells of rats -- a possible mechanism of intrasinusoidal microthrombus formation and liver dysfunction
    Masane Kume
    Department of Molecular Pathobiology, Mie University School of Medicine, Tsu City, Mie 514 8507, Japan
    J Hepatol 38:9-17. 2003
    ....
  48. ncbi Separation and characterization of the molecular species of thrombomodulin in the plasma of diabetic patients
    S Uehara
    Department of Internal Medicine, Ohtaki Onsen Hospital, Ohtaki, Usugun, Hokkaido, Japan
    Thromb Res 104:325-32. 2001
    ..These findings suggest that a fluctuation in the blood glucose level is significantly related to vascular EC damage in DM...
  49. ncbi Erectile and endothelial dysfunction in Type II diabetes: a possible link
    L De Angelis
    Department of Geriatrics and Metabolic Diseases, Second University of Naples, Italy
    Diabetologia 44:1155-60. 2001
    ..The aim of this study was to evaluate the relation between erectile dysfunction and endothelial functions, coagulation activation, peripheral and autonomic neuropathy in men with Type II (non-insulin-dependent) diabetes mellitus...
  50. ncbi Relationship between plasma soluble thrombomodulin levels and insulin resistance syndrome in type 2 diabetes: a comparison with von Willebrand factor
    Y Aso
    Department of Medicine, Koshigaya Hospital, Dokkyo University School of Medicine, Saitama, Japan
    Exp Clin Endocrinol Diabetes 109:210-6. 2001
    ....
  51. ncbi Localization of thrombomodulin in pericryptal fibroblasts of the rat duodenum
    Tateo Daimon
    Department of Anatomy, School of Medicine, Teikyo University, 2 11 1 Kaga, Itabashi ku, 173, Tokyo, Japan
    Histochem Cell Biol 121:311-7. 2004
    ..The functional significance of TM in pericryptal fibroblasts is discussed...
  52. ncbi Prothrombotic markers in familial combined hyperlipidemia: evidence of endothelial cell activation and relation to metabolic syndrome
    Anna M Georgieva
    Department of Internal Medicine, Cardiovascular Research Institute Maastricht, Academic Hospital Maastricht and University of Maastricht, AZ Maastricht, The Netherlands
    Atherosclerosis 175:345-51. 2004
    ....
  53. ncbi Neuroprotective effects of recombinant thrombomodulin in controlled contusion spinal cord injury implicates thrombin signaling
    Barry W Festoff
    Neurobiology Research Laboratory, Heartland Network, Department of Veterans Affairs Medical Center, Kansas City, Missouri 64128, USA
    J Neurotrauma 21:907-22. 2004
    ..They identify a neuroprotective role for rTM by its inhibition of thrombin generation and blockade of PAR activation...
  54. ncbi [Is soluble thrombomodulin a molecular marker of endothelial cell injury in children and adolescents with arterial hypertension?]
    Katarzyna Wojtkielewicz
    II Klinika Chorób Dzieci, Akademia Medyczna, Ul Waszyngtona 17, 15 274 Białystok, Poland
    Med Wieku Rozwoj 10:893-902. 2006
    ..TM may be cleaved to its soluble (sTM) form by proinflammatory mediators and then detected in the circulation...
  55. ncbi Low soluble thrombomodulin activity and antigen is associated with a family history of heart disease while a high level is associated with a personal history of heart disease in type 2 diabetes
    Constantine J Konstantoulas
    Thromb Haemost 97:161-4. 2007
  56. ncbi Soluble thrombomodulin as a predictor of type 2 diabetes: results from the MONICA/KORA Augsburg case-cohort study, 1984-1998
    B Thorand
    GSF National Research Centre for Environment and Health, Institute of Epidemiology, Neuherberg, Germany
    Diabetologia 50:545-8. 2007
    ..Since CHD and type 2 diabetes share many risk factors, the aim of this study was to assess whether elevated sTM levels are associated with a lower incidence of type 2 diabetes...
  57. ncbi Elevation of intracellular cAMP up-regulated thrombomodulin mRNA in cultured vascular endothelial cells derived from spontaneous type-II diabetes mellitus model rat
    Masanori Sunagawa
    1st Department of Physiology, Unit of Physiological Science, School of Medicine, University of the Ryukyus, Okinawa, Japan
    Endothelium 13:325-33. 2006
    ..5-fold at 24 h. Therefore, elevation of intracellular cAMP by db-cAMP or cilostazol up-regulated TM mRNA expression in cultured VECs from OLETF rats...
  58. ncbi Markers for endothelial dysfunction, but not markers for oxidative stress correlate with classical risk factors and the severity of coronary artery disease. (A subgroup analysis from the Ludwigshafen Risk and Cardiovascular Health Study)
    Johannes Ruef
    Red Cross Hospital Cardiology Center, Frankfurt, Germany
    Scand Cardiovasc J 40:274-9. 2006
    ..Endothelial dysfunction and oxidative stress are involved in atherogenesis. In the search for predictors of vascular disease markers for endothelial dysfunction and oxidative stress were analyzed...
  59. ncbi Clinical and immunoserological characteristics of mixed connective tissue disease associated with pulmonary arterial hypertension
    J Vegh
    3rd Department of Internal Medicine, University of Debrecen, Medical and Health Science Centre, Debrecen, Hungary
    Scand J Immunol 64:69-76. 2006
    ..550). In conclusion, our results suggest that in MCTD the presence of AECA and endothelial cell activation may play a role in the development of PAH and in the maintenance of obliterative vascular processes...
  60. ncbi Impaired flow-mediated vasodilation, carotid artery intima-media thickening, and elevated endothelial plasma markers in obese children: the impact of cardiovascular risk factors
    Andreas Alexander Meyer
    Division of Pediatric Cardiology, Childrens Hospital, University of Rostock, Rostock, Germany
    Pediatrics 117:1560-7. 2006
    ..Associations between early morphologic and functional vascular changes, surrogate soluble markers of early atherosclerosis, and the cardiovascular risk profile were determined...
  61. ncbi Synergistic association of metabolic syndrome and overt nephropathy with elevated asymmetric dimethylarginine in serum and impaired cutaneous microvasodilation in patients with type 2 diabetes
    Ruriko Yamamoto
    Department of Internal Medicine, Koshigaya Hospital, Dokkyo Medical University, Koshigaya, Saitama 343 8555, Japan
    Diabetes Care 29:928-30. 2006
  62. ncbi The anticoagulant protein C pathway
    Bjorn Dahlback
    Department of Laboratory Medicine, Clinical Chemistry, Lund University, The Wallenberg Laboratory, University Hospital, Malmo, SE 205 02 Malmo, Sweden
    FEBS Lett 579:3310-6. 2005
    ..Genetic defects affecting the protein C system are the most common risk factors of venous thrombosis. The protein C system contains multi-domain proteins, the molecular recognition of which will be reviewed...
  63. ncbi Non-viral in vivo thrombomodulin gene transfer prevents early loss of thromboresistance of grafted veins
    Noriyuki Tabuchi
    Department of Cardio Thoracic Surgery, Tokyo Medical and Dental University Graduate School, Tokyo, Japan
    Eur J Cardiothorac Surg 26:995-1001. 2004
    ....
  64. ncbi cDNA cloning and sequencing, gene expression, and immunolocalization of thrombomodulin in the Sprague-Dawley rat
    J Wang
    Department of Surgery, University of Arkansas for Medical Sciences and John L McClellan VAMC, Little Rock 72205, USA
    DNA Res 6:57-62. 1999
    ..The alveolar capillaries of lung showed the strongest immunoreactivity, whereas the endothelium of hepatic sinusoids and cerebral cortex were virtually negative...