Taz

Summary

Gene Symbol: Taz
Description: tafazzin
Alias: tafazzin, Barth syndrome), cardiomyopathy, dilated 3A (X-linked), endocardial fibroelastosis 2, tafazzin (cardiomyopathy, dilated 3A (X-linked), tafazzin (cardiomyopathy, dilated 3A (X-linked); endocardial fibroelastosis 2; Barth syndrome)
Species: rat

Top Publications

  1. doi Metabolism and function of mitochondrial cardiolipin
    Mindong Ren
    Department of Anesthesiology, New York University School of Medicine, New York, USA Department of Cell Biology, New York University School of Medicine, New York, USA
    Prog Lipid Res 55:1-16. 2014
  2. pmc The Hippo pathway mediates inhibition of vascular smooth muscle cell proliferation by cAMP
    Tomomi E Kimura
    Bristol Heart Institute, School of Clinical Sciences, University of Bristol, Bristol BS2 8HW, UK
    J Mol Cell Cardiol 90:1-10. 2016
  3. doi Tafazzin knockdown interrupts cell cycle progression in cultured neonatal ventricular fibroblasts
    Quan He
    Diabetes and Obesity Research Center, Sanford Burnham Medical Research Institute, Orlando, Florida and
    Am J Physiol Heart Circ Physiol 305:H1332-43. 2013
  4. ncbi Infantile dilated X-linked cardiomyopathy, G4.5 mutations, altered lipids, and ultrastructural malformations of mitochondria in heart, liver, and skeletal muscle
    John J Bissler
    Department of Pediatrics, University of Cincinnati, Cincinnati, Ohio, USA
    Lab Invest 82:335-44. 2002
  5. ncbi Only one splice variant of the human TAZ gene encodes a functional protein with a role in cardiolipin metabolism
    Frederic M Vaz
    Departments of Clinical Chemistry and Pediatrics, Emma Children s Hospital, Academic Medical Center, University of Amsterdam, P O Box 22700, 1100 DE Amsterdam, The Netherlands
    J Biol Chem 278:43089-94. 2003
  6. doi Tafazzin knockdown causes hypertrophy of neonatal ventricular myocytes
    Quan He
    Hypertension and Vascular Research Division, Department of Internal Medicine, Henry Ford Hospital, 2799 W Grand Blvd, Detroit, MI 48202 2689, USA
    Am J Physiol Heart Circ Physiol 299:H210-6. 2010

Scientific Experts

  • Frederic M Vaz
  • J J Bissler
  • Quan He
  • Tomomi E Kimura
  • Mindong Ren
  • Aparna Duggirala
  • Stephen White
  • Andrew C Newby
  • Graciela B Sala-Newby
  • Mark Bond
  • Madeleine C Smith
  • Michael Schlame
  • Colin K L Phoon

Detail Information

Publications6

  1. doi Metabolism and function of mitochondrial cardiolipin
    Mindong Ren
    Department of Anesthesiology, New York University School of Medicine, New York, USA Department of Cell Biology, New York University School of Medicine, New York, USA
    Prog Lipid Res 55:1-16. 2014
    ..We also give an overview of the various phenotypes of cardiolipin deficiency in different organisms. ..
  2. pmc The Hippo pathway mediates inhibition of vascular smooth muscle cell proliferation by cAMP
    Tomomi E Kimura
    Bristol Heart Institute, School of Clinical Sciences, University of Bristol, Bristol BS2 8HW, UK
    J Mol Cell Cardiol 90:1-10. 2016
    ..Here we investigated the role of components of the growth-regulatory Hippo pathway, specifically the transcription factor TEAD and its co-factors YAP and TAZ in VSMC.
  3. doi Tafazzin knockdown interrupts cell cycle progression in cultured neonatal ventricular fibroblasts
    Quan He
    Diabetes and Obesity Research Center, Sanford Burnham Medical Research Institute, Orlando, Florida and
    Am J Physiol Heart Circ Physiol 305:H1332-43. 2013
    Mutation of the mitochondrial protein tafazzin causes dilated cardiomyopathy in Barth syndrome. Previous studies have shown that tafazzin knockdown promotes hypertrophy of neonatal cardiac myocytes...
  4. ncbi Infantile dilated X-linked cardiomyopathy, G4.5 mutations, altered lipids, and ultrastructural malformations of mitochondria in heart, liver, and skeletal muscle
    John J Bissler
    Department of Pediatrics, University of Cincinnati, Cincinnati, Ohio, USA
    Lab Invest 82:335-44. 2002
    ..5 mutations. Electron microscopy of promptly fixed myocardial biopsy specimens has a role in defining the differential diagnosis of DCM. Mutational analysis of the G4.5 gene also serves this purpose...
  5. ncbi Only one splice variant of the human TAZ gene encodes a functional protein with a role in cardiolipin metabolism
    Frederic M Vaz
    Departments of Clinical Chemistry and Pediatrics, Emma Children s Hospital, Academic Medical Center, University of Amsterdam, P O Box 22700, 1100 DE Amsterdam, The Netherlands
    J Biol Chem 278:43089-94. 2003
    Barth syndrome (BTHS) is an X-linked recessive disorder caused by mutations in the TAZ gene and is characterized by cardiomyopathy, short stature, neutropenia, and 3-methylglutaconic aciduria...
  6. doi Tafazzin knockdown causes hypertrophy of neonatal ventricular myocytes
    Quan He
    Hypertension and Vascular Research Division, Department of Internal Medicine, Henry Ford Hospital, 2799 W Grand Blvd, Detroit, MI 48202 2689, USA
    Am J Physiol Heart Circ Physiol 299:H210-6. 2010
    Mutation of the mitochondrial protein tafazzin causes dilated cardiomyopathy in Barth syndrome...