Genomes and Genes
Gene Symbol: Tap1
Description: transporter 1, ATP binding cassette subfamily B member
Alias: Abcb2, Cim, Tap2, antigen peptide transporter 1, APT1, ATP-binding cassette sub-family B member 2, peptide transporter TAP1, transporter 1 ABC (ATP binding cassette), transporter 1 ATP-binding cassette sub-family B, transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
- Lack of association between gene polymorphism of transporters associated with antigen processing and allergic rhinitis in a Japanese populationKazuhiko Takeuchi
Department of Otorhinolaryngology, Mie University School of Medicine, Tsu, Japan
Ann Otol Rhinol Laryngol 111:460-3. 2002Gene products of TAP1 and TAP2 (transporters associated with antigen processing) are involved in antigen presentation. It has been reported that polymorphisms in the TAP1 gene are associated with atopy in Tunisians...
- MHC class II region encoding proteins related to the multidrug resistance family of transmembrane transportersE V Deverson
Department of Immunology, Cambridge Research Station, UK
Nature 348:738-41. 1990..Here we show that one of these, the rat cim gene, maps to a highly polymorphic part of the MHC class II region encoding two novel members of the family of ..
- Natural polymorphisms in Tap2 influence negative selection and CD4∶CD8 lineage commitment in the ratJonatan Tuncel
Section for Medical Inflammation Research, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden
PLoS Genet 10:e1004151. 2014..We mapped this effect to the transporter associated with antigen processing 2 (Tap2) in the MHC-II region and the classical MHC class I gene(s) (RT1-A) in the MHC-I region...
- The interaction of the polymorphisms in transporter of antigen peptides (TAP) and lymphotoxin alpha (LT-alpha) genes and atopic diseases in the Czech populationL Izakovicova Holla
Institute of Pathological Physiology, Medical Faculty, Masaryk University Brno, Czech Republic
Clin Exp Allergy 31:1418-23. 2001..These genes, inducible by interferon gamma, as well as lymphotoxin alpha (LT-alpha), are located in the HLA region. Their involvement in immune response regulation makes them candidate atopy susceptibility genes...
- Polymorphisms in inflammation genes (angiotensinogen, TAP1 and TNF-beta) in psoriasisV Vasku
First Department of Dermatovenerology, University Hospital, Brno, Czech Republic
Arch Dermatol Res 292:531-4. 2000..of the polymorphisms in angiotensinogen [M235T ATG, A(-6)G ATG], in transporters associated with antigen processing TAP1 (TAP1*0101, TAP*02011 and TAP1*0301) and in lymphotoxin alpha (TNFbeta) (NcoI in intron 1) were detected by ..
- Variation in HLA class I antigen-processing genes and susceptibility to human papillomavirus type 16-associated cervical cancerAlina Deshpande
Decision Applications Division, Los Alamos National Laboratory, Los Alamos, California, USA
J Infect Dis 197:371-81. 2008..Genetic variation in these genes may affect protein structure and function and, consequently, the ability of an individual to clear HPV infection...
- TAP1 and TAP2 gene polymorphisms in Korean patients with allergic rhinitisKyung Rae Kim
Department of Otolaryngology Head and Neck Surgery, School of Medicine, Hanyang University, Seoul, Korea
J Korean Med Sci 22:825-31. 2007..TAP1 and TAP2 genotyping were performed on 110 allergic rhinitis patients and 107 healthy controls...
- Susceptibility to Reiter's syndrome is associated with alleles of TAP genesK S Barron
National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
Arthritis Rheum 38:684-9. 1995..The recently described TAP genes (transporters associated with antigen processing) are potential candidates because they are polymorphic and their function is to transport antigenic peptides to be loaded in HLA class I molecules...
- TAP1, TAP2, and HLA-DR2 alleles are predictors of cervical cancer riskBobbie S Gostout
Section of Gynecologic Surgery, Mayo Clinic, Rochester, MN 55905, USA
Gynecol Oncol 88:326-32. 2003..We evaluated immune response genes in the HLA region of chromosome 6 to see if individual or interactive associations with cervical cancer risk could be identified...
- Transporter associated with antigen processing and the chaperone tapasin: are non-classical HLA genes keys to the pathogenesis of schizophrenia?Barbara Fellerhoff
Institute for Immunology, University of Munich, Goethestrasse 31, D 80336 Munich, Germany
Med Hypotheses 72:535-8. 2009..a small group of schizophrenic patients and control individuals allele frequencies of the transporter proteins TAP1/TAP2, which select the immunoproteasome-tailored peptides for transportation...
- Association of TAP 1 and 2 gene polymorphisms with human immunodeficiency virus-tuberculosis co-infectionSharada Ramaseri Sunder
LEPRA India Blue Peter Public Health and Research Centre, Cherlapally, Hyderabad, India
Hum Immunol 72:908-11. 2011..by transporter associated with antigen processing (TAP), an integral ER membrane protein composed of two subunits, TAP1 and TAP2...
- TAP1 and TAP2 polymorphisms associated with ankylosing spondylitis in genetically homogenous Chinese Han populationMingliang Feng
Shanghai Blood Center, Shanghai, People s Republic of China
Hum Immunol 70:257-61. 2009..In this study, we investigated the association of TAP1 and TAP2 polymorphisms in genetically homogenous Chinese AS patients...
- Polymorphisms of the TAP1 and TAP2 transporter genes in Japanese SLEF Takeuchi
Department of Medicine and Physical Therapy, Faculty of Medicine, University of Tokyo, Japan
Ann Rheum Dis 55:924-6. 1996To determine how polymorphism of transporter associated with antigen processing 1 and 2 (TAP1 and 2) alleles contributed to the pathogenesis of systemic lupus erythematosus (SLE) in Japanese patients.
- Down-regulation of HLA class I antigen-processing machinery components in esophageal squamous cell carcinomas: association with disease progressionQiao Liu
Department of Cellular and Molecular Biology, Cancer Institute and Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China
Scand J Gastroenterol 44:960-9. 2009....
- Association of TAP1 and TAP2 gene polymorphisms with systemic sclerosis in Korean patientsYeong Wook Song
Department of Internal Medicine, Seoul National University College of Medicine, 28 Yongon Dong, Chongno Gu, Seoul, Korea
Hum Immunol 66:810-7. 2005..TAP1 and TAP2 gene polymorphisms were analyzed in 61 Korean patients with SSc and 100 ethnically matched healthy Koreans by ..
- Transporter associated with antigen processing gene 1 codon 333 and codon 637 polymorphisms are associated with primary open-angle glaucomaHui Ju Lin
Department of Ophthalmology, China Medical University Hospital, Taichung, Taiwan
Mol Diagn 8:245-52. 2004..The TAP gene polymorphisms we evaluated were TAP1-1 codon 333 A/G (Ile-Val), TAP1-2 codon 637 (Asp-Gly), TAP2-1 codon 379 (Val-Ile), TAP2-2 codon 665 (Thr-Ala) and codon 687 (Stop-Gln), and TAP2-3 codon 565 (Ala-Tht)...
- The varicellovirus UL49.5 protein blocks the transporter associated with antigen processing (TAP) by inhibiting essential conformational transitions in the 6+6 transmembrane TAP core complexMarieke C Verweij
Department of Medical Microbiology, Center of Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands
J Immunol 181:4894-907. 2008..of TAP required for the translocation of peptides into the endoplasmic reticulum, and 2) by targeting TAP1 and TAP2 for proteasomal degradation. At present, it is unknown whether UL49.5 interacts with TAP1, TAP2, or both...
- Transporter associated with antigen processing (TAP) 1 gene polymorphisms in patients with hypersensitivity pneumonitisArnoldo Aquino-Galvez
Instituto Nacional de Enfermedades Respiratorias, Tlalpan 4502, Col Seccion XVI, 14080, Mexico City, Mexico
Exp Mol Pathol 84:173-7. 2008..The distribution of single nucleotide polymorphisms (SNPs) in TAP1 genes was analyzed in 73 hypersensitivity pneumonitis (HP) patients and 58 normal subjects...
- TAP1 gene AccI polymorphism is associated with atopic bronchial asthmaLiang Wen Hang
Department of Internal Medicine, China Medical College Hospital, Taichung, Taiwan
J Clin Lab Anal 17:57-60. 2003..A transporter associated with the antigen processing 1 gene (TAP1) is involved in antigen processing, and is therefore considered to play a role in the pathogenesis of bronchial ..
- Molecular architecture of the TAP-associated MHC class I peptide-loading complexElke Rufer
Friedrich Loeffler Institute, Federal Research Institute for Animal Health, Institute of Immunology, Tuebingen, Germany
J Immunol 179:5717-27. 2007..peptide-receptive MHC class I (MHC-I) and accessory chaperones to the N-terminal regions of the TAP subunits TAP1 and TAP2...
- The role of TAP1 and TAP2 gene polymorphism in idiopathic bronchiectasis in childrenDeniz Dogru
Pediatric Pulmonary Medicine Unit, Faculty of Medicine, Hacettepe University, Ankara, Turkey
Pediatr Pulmonol 42:237-41. 2007..DNA was extracted and gene polymorphisms for TAP1 and TAP2 were studied...
- Distinct structural and functional properties of the ATPase sites in an asymmetric ABC transporterErik Procko
Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
Mol Cell 24:51-62. 2006..Since asymmetry of the ATPase site motifs is a feature of many mammalian homologs, our proposed model has broad implications for ABC transporters...
- Biogenesis of functional antigenic peptide transporter TAP requires assembly of pre-existing TAP1 with newly synthesized TAP2Kirstin Keusekotten
Institute for Genetics, University of Cologne, Zuelpicher Strasse 47, D 50674 Cologne, Germany
J Biol Chem 281:17545-51. 2006..TAP is a heterodimeric transmembrane protein that comprises the homologous subunits TAP1 and TAP2. As for many other oligomeric protein complexes, which are synthesized in the ER, the process of subunit assembly ..
- Functional role of C-terminal sequence elements in the transporter associated with antigen processingSarah Ehses
Institute for Genetics, University of Cologne, Zulpicher Strasse 47, 50674 Cologne, Germany
J Immunol 174:328-39. 2005..TAP consists of two subunits (TAP1 and TAP2), each with a transmembrane (TMD) and a nucleotide-binding (NBD) domain...
- Polymorphism of transporter associated with antigen presentation 1 as a potential determinant for severity of disease in recurrent respiratory papillomatosis caused by human papillomavirus types 6 and 11Andrea Vambutas
North Shore Long Island Jewish Research Institute, and Department of Otolaryngology, Long Island Jewish Medical Center, New Hyde Park, New York 11040, USA
J Infect Dis 189:871-9. 2004..One way in which HPV subverts the immune system in RRP is by interfering with TAP1 (transporter associated with antigen presentation 1)...
- The distinct nucleotide binding states of the transporter associated with antigen processing (TAP) are regulated by the nonhomologous C-terminal tails of TAP1 and TAP2Hicham Bouabe
Institute for Genetics, University of Cologne, Germany
Eur J Biochem 270:4531-46. 2003..TAP comprises two polypeptides, TAP1 and TAP2, each with an N-terminal transmembrane domain and a C-terminal cytosolic nucleotide binding domain (NBD)...
- TAP1 and TAP2 transporter genes and predisposition to insulin dependent diabetes mellitusS Caillat-Zucman
I N S E R M U25, Hopital Necker, Paris
C R Acad Sci III 315:535-9. 1992..The participation of TAP1 and TAP2 genes, located in the MHC region and coding for antigenic peptide transporters, was investigated in 116 IDDM ..
- Crystal structures of two rat MHC class Ia (RT1-A) molecules that are associated differentially with peptide transporter alleles TAP-A and TAP-BMarkus G Rudolph
Department of Molecular Biology and Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
J Mol Biol 324:975-90. 2002..This loop change contributes to profound changes in the shape of the A-pocket in the peptide-binding groove and may explain the function of RT1-A1(c) as an inhibitory natural killer cell ligand...
- Interactions formed by individually expressed TAP1 and TAP2 polypeptide subunitsAntony N Antoniou
Division of Cell Biology and Immunology, School of Life Sciences, University of Dundee, Dundee, UK
Immunology 106:182-9. 2002..TAP comprises two polypeptides, TAP1 and TAP2, each a 'half-transporter' encoding a transmembrane domain and a nucleotide-binding domain...
- Three-dimensional structure of transporter associated with antigen processing (TAP) obtained by single Particle image analysisG Velarde
Department of Biomolecular Sciences, UMIST, Manchester M60 1QD, United Kingdom
J Biol Chem 276:46054-63. 2001..Immunoaffinity-purified TAP particles comprising TAP1 and TAP2 polypeptides, and TAP2 particles alone were characterized after detergent solubilization and studied by ..
- Functional asymmetry of the ATP-binding-cassettes of the ABC transporter TAP is determined by intrinsic properties of the nucleotide binding domainsO Daumke
Institute for Genetics, University of Cologne, Germany
Eur J Biochem 268:4776-86. 2001..TAP consists of two polypeptides (TAP1 and TAP2) each with an N-terminal transmembrane (TMD) and a C-terminal nucleotide binding domain (NBD)...
- Altered expression of TAP-1 and major histocompatibility complex class I in laryngeal papillomatosis: correlation of TAP-1 with diseaseA Vambutas
Department of Otolaryngology, Long Island Jewish Medical Center, The Long Island Campus for the Albert Einstein College of Medicine, New Hyde Park, New York 11040, USA
Clin Diagn Lab Immunol 7:79-85. 2000..This up-regulation of class I MHC antigen at the cell surface potentially allows the infected cell to become a target for the immune system again. This finding provides some promise for nonsurgical treatment of laryngeal papillomas...
- Nucleotide binding by TAP mediates association with peptide and release of assembled MHC class I moleculesM R Knittler
Institute for Genetics University of Cologne D 50674, Cologne, Germany
Curr Biol 9:999-1008. 1999..To investigate the role of TAP in this process, mutations that block nucleotide binding were introduced into the ATP-binding site of TAP...
- Screening of the TAP1 gene by denaturing gradient gel electrophoresis in insulin-dependent diabetes mellitus: detection and comparison of new polymorphisms between patients and controlsG Yan
Immunobiology Laboratory, Massachusetts General Hospital, Charlestown 02129, USA
Tissue Antigens 50:576-85. 1997New protective or disease-associated polymorphisms in the TAP1 gene were sought in insulin-dependent diabetes mellitus (IDDM) patients with the use of denaturing gradient gel electrophoresis (DGGE) screening of genomic DNA...
- Reduced expression of Tap1 and Lmp2 antigen-processing genes in the nonobese diabetic (NOD) mouse due to a mutation in their shared bidirectional promoterG Yan
Immunobiology Laboratory, Massachusetts General Hospital East, Charlestown 02129, USA
J Immunol 159:3068-80. 1997The MHC is an essential contributor to autoimmunity. Lmp2 and Tap1 are genes located in the MHC class II region, and they encode proteins participating in the generation and transport of endogenous peptides for T cell education...
- Evaluation of TAP1 polymorphisms with insulin dependent diabetes mellitus in Finnish diabetic patients. The Childhood Diabetes in Finland (DiMe) Study GroupL Ma
Immunobiology Laboratory, Massachusetts General Hospital, Charlestown, USA
Hum Immunol 53:159-66. 1997..Five coding region variants of TAP1 were typed in a cohort of well characterized Finnish patients with diabetes (n = 119) and compared to racially ..
- Resistance to natural killer cell lysis conferred by TAP1/2 genes in human antigen-processing mutant cellsM Salcedo
Microbiology and Tumor Biology Center, Karolinska Institute, Stockholm, Sweden
J Immunol 152:1702-8. 1994..174, and its derivative T2, have a large homozygous deletion in the MHC class II region encompassing the TAP1 and TAP2 as well as the LMP2 and LMP7 genes...
- TAP1 mutant mice are deficient in antigen presentation, surface class I molecules, and CD4-8+ T cellsL van Kaer
Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge 02139
Cell 71:1205-14. 1992..These properties are strikingly similar to those described for the TAP2 mutant cell line RMA-S...
- [Rehabilitative evaluation of 18 cases of anterior cruciate ligament lesions surgically treated by the Kenneth-Jones technique]G Masserano
Servizio di Recupero e Rieducazione Funzionale, USSL n 47, Ospedale degli Infermi, Biella, Vercelli
Minerva Med 83:89-91. 1992
- TAP-1/E7 INTERACTION: ROLE IN RESPIRATORY PAPILLOMASAndrea Vambutas; Fiscal Year: 2004..To determine whether the interaction between TAP-1 and E7 in naturally occurring infections sufficient to result in a loss of peptide transport and whether this loss correlates with viral protein load and the patients clinical course. ..