Syt7

Summary

Gene Symbol: Syt7
Description: synaptotagmin 7
Alias: SytVII, synaptotagmin-7, protein Syt7, synaptotagmin VII
Species: rat

Top Publications

  1. ncbi Alternative splicing of synaptotagmins involving transmembrane exon skipping
    M Craxton
    Medical Research Council, Laboratory of Molecular Biology, Hills Road, Cambridge, UK
    FEBS Lett 460:417-22. 1999
  2. pmc Synaptotagmin VII regulates Ca(2+)-dependent exocytosis of lysosomes in fibroblasts
    I Martinez
    Section of Microbial Pathogenesis, Boyer Center for Molecular Medicine, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Cell Biol 148:1141-49. 2000
  3. ncbi Synaptotagmin VII as a plasma membrane Ca(2+) sensor in exocytosis
    S Sugita
    Center for Basic Neuroscience, Department of Molecular Genetics and, Howard Hughes Medical Institute, The University of Texas Southwestern, Medical Center, 6000 Harry Hines Boulevard NA4 118, Dallas TX 75390, USA
    Neuron 30:459-73. 2001
  4. ncbi Plasma membrane repair is mediated by Ca(2+)-regulated exocytosis of lysosomes
    A Reddy
    Section of Microbial Pathogenesis, Boyer Center for Molecular Medicine, Yale University School of Medicine, New Haven, CT 06520, USA
    Cell 106:157-69. 2001
  5. pmc Alternative splicing isoforms of synaptotagmin VII in the mouse, rat and human
    Mitsunori Fukuda
    Fukuda Initiative Research Unit, RIKEN The Institute of Physical and Chemical Research, 2 1 Hirosawa, Wako, Saitama 351 0198, Japan
    Biochem J 365:173-80. 2002
  6. ncbi Ca(2+)-dependent and -independent activities of neural and non-neural synaptotagmins
    C Li
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas 75235, USA
    Nature 375:594-9. 1995
  7. pmc Regulation of exocytosis and fusion pores by synaptotagmin-effector interactions
    Zhen Zhang
    National Institute of Neurological Disorders and Stroke, Bethesda, MD 20892, USA
    Mol Biol Cell 21:2821-31. 2010
  8. ncbi Synaptotagmin VII is targeted to dense-core vesicles and regulates their Ca2+ -dependent exocytosis in PC12 cells
    Mitsunori Fukuda
    Fukuda Initiative Research Unit, RIKEN The Institute of Physical and Chemical Research, 2 1 Hirosawa, Wako, Saitama 351 0198, Japan
    J Biol Chem 279:52677-84. 2004
  9. doi Synaptotagmins bind calcium to release insulin
    Benoit R Gauthier
    Dept of Cell Physiology and Metabolism, University Medical Center, 1211 Geneva 4, Switzerland
    Am J Physiol Endocrinol Metab 295:E1279-86. 2008
  10. pmc Synaptotagmin VII is targeted to secretory organelles in PC12 cells, where it functions as a high-affinity calcium sensor
    Ping Wang
    Department of Physiology, University of Wisconsin, 1300 University Ave, SMI 129, Madison, WI 53706, USA
    Mol Cell Biol 25:8693-702. 2005

Scientific Experts

  • Motojiro Yoshihara
  • Mitsunori Fukuda
  • Benoit R Gauthier
  • M Craxton
  • Zhen Zhang
  • Edwin R Chapman
  • Kathrin Neuland
  • Xiao Qing Dai
  • Hidetada Matsuoka
  • Meyer B Jackson
  • Mingshan Xue
  • JiangLi Li
  • Thomas C Sudhof
  • Ping Wang
  • Swathi K Rao
  • Shoumita Dasgupta
  • Tuhin Virmani
  • Neeti Sharma
  • Manfred Frick
  • A Reddy
  • S Sugita
  • Deepshika Ramanan
  • Jonathan Rehfuss
  • Herbert Y Gaisano
  • Yao Wu
  • N W Andrews
  • Marina Casimir
  • Greg Plummer
  • Jocelyn E Manning Fox
  • F Mark Dunning
  • Catherine Hajmrle
  • Zhao Wang
  • Youhou Kang
  • Patrick E MacDonald
  • Masumi Inoue
  • Jun Nakamura
  • Keita Harada
  • Ok Ho Shin
  • Enfu Hui
  • LiYi Li
  • Josep Rizo
  • Diana R Tomchick
  • Timothy K Craig
  • Christian Rosenmund
  • Chad A Brautigam
  • I Martinez
  • Rongying Zhang
  • Zhengxing Wu
  • Tao Xu
  • Yang Xiao
  • Wei Zhou
  • T C Sudhof
  • David A Richards
  • Michael C Chicka
  • Akhil Bhalla
  • Chau Huynh
  • Thierry Galli
  • Norma W Andrews
  • Veronique Proux-Gillardeaux
  • Ege T Kavalali
  • Weiping Han
  • Regis B Kelly
  • Xinran Liu
  • Y Lao
  • R Fernandez-Chacon
  • S Butz
  • X Liu
  • E V Caler
  • W Han
  • K Fowler
  • J Morehead
  • T Hellevik
  • S Chakrabarti
  • C Li
  • N Brose
  • J Z Zhang
  • B Ullrich
  • R G Anderson

Detail Information

Publications21

  1. ncbi Alternative splicing of synaptotagmins involving transmembrane exon skipping
    M Craxton
    Medical Research Council, Laboratory of Molecular Biology, Hills Road, Cambridge, UK
    FEBS Lett 460:417-22. 1999
    ..Although the expression of most synaptotagmins predominates in neural tissue, we find that by contrast, synaptotagmin 6 is more abundant in thymus...
  2. pmc Synaptotagmin VII regulates Ca(2+)-dependent exocytosis of lysosomes in fibroblasts
    I Martinez
    Section of Microbial Pathogenesis, Boyer Center for Molecular Medicine, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Cell Biol 148:1141-49. 2000
    ..Antibodies against the Syt VII C(2)A domain are also inhibitory in both assays, indicating that Syt VII plays a key role in the regulation of Ca(2+)-dependent lysosome exocytosis...
  3. ncbi Synaptotagmin VII as a plasma membrane Ca(2+) sensor in exocytosis
    S Sugita
    Center for Basic Neuroscience, Department of Molecular Genetics and, Howard Hughes Medical Institute, The University of Texas Southwestern, Medical Center, 6000 Harry Hines Boulevard NA4 118, Dallas TX 75390, USA
    Neuron 30:459-73. 2001
    ..We now propose that synaptotagmin VII functions as a plasma membrane Ca(2+) sensor in synaptic exocytosis complementary to vesicular ..
  4. ncbi Plasma membrane repair is mediated by Ca(2+)-regulated exocytosis of lysosomes
    A Reddy
    Section of Microbial Pathogenesis, Boyer Center for Molecular Medicine, Yale University School of Medicine, New Haven, CT 06520, USA
    Cell 106:157-69. 2001
    ..These findings reveal a fundamental, novel role for lysosomes: as Ca(2+)-regulated exocytic compartments responsible for plasma membrane repair...
  5. pmc Alternative splicing isoforms of synaptotagmin VII in the mouse, rat and human
    Mitsunori Fukuda
    Fukuda Initiative Research Unit, RIKEN The Institute of Physical and Chemical Research, 2 1 Hirosawa, Wako, Saitama 351 0198, Japan
    Biochem J 365:173-80. 2002
    b>Synaptotagmin VII (Syt VII) has been proposed to regulate several different types of Ca2+-dependent exocytosis, but its subcellular localization (lysosome or plasma membrane) and the number of alternative splicing isoforms of Syt VII (..
  6. ncbi Ca(2+)-dependent and -independent activities of neural and non-neural synaptotagmins
    C Li
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas 75235, USA
    Nature 375:594-9. 1995
    ..The same C2 domains also bind syntaxin as a function of Ca2+ but the Ca(2+)-concentration dependence of Syt I, II and V (> 200 microM) differs from that of Syt III and VII (< 10 microM).(ABSTRACT TRUNCATED AT 250 WORDS)..
  7. pmc Regulation of exocytosis and fusion pores by synaptotagmin-effector interactions
    Zhen Zhang
    National Institute of Neurological Disorders and Stroke, Bethesda, MD 20892, USA
    Mol Biol Cell 21:2821-31. 2010
    ..This associates the syt-PS interaction with two distinct kinetic steps in Ca(2+) triggered exocytosis and supports a role for the syt-PS interaction in stabilizing open fusion pores...
  8. ncbi Synaptotagmin VII is targeted to dense-core vesicles and regulates their Ca2+ -dependent exocytosis in PC12 cells
    Mitsunori Fukuda
    Fukuda Initiative Research Unit, RIKEN The Institute of Physical and Chemical Research, 2 1 Hirosawa, Wako, Saitama 351 0198, Japan
    J Biol Chem 279:52677-84. 2004
    ....
  9. doi Synaptotagmins bind calcium to release insulin
    Benoit R Gauthier
    Dept of Cell Physiology and Metabolism, University Medical Center, 1211 Geneva 4, Switzerland
    Am J Physiol Endocrinol Metab 295:E1279-86. 2008
    ..Cumulating evidence emphasizes the crucial role of synaptotagmin VII and IX as mediators of glucose-induced insulin secretion.
  10. pmc Synaptotagmin VII is targeted to secretory organelles in PC12 cells, where it functions as a high-affinity calcium sensor
    Ping Wang
    Department of Physiology, University of Wisconsin, 1300 University Ave, SMI 129, Madison, WI 53706, USA
    Mol Cell Biol 25:8693-702. 2005
    ..These data support the hypothesis that the complement of syt's expressed by a cell, in conjunction with their metal affinity, determines the divalent cation sensitivity of exocytosis...
  11. ncbi Synaptotagmin VII splice variants alpha, beta, and delta are expressed in pancreatic beta-cells and regulate insulin exocytosis
    Benoit R Gauthier
    Department of Cell Physiology and Metabolism, University Medical Center, 1211 Geneva 4, Switzerland
    FASEB J 22:194-206. 2008
    ..b>SYTVII was also proposed to regulate insulin exocytosis, but its subcellular location and number of alternative splice ..
  12. pmc Synaptotagmin-7 links fusion-activated Ca²⁺ entry and fusion pore dilation
    Kathrin Neuland
    Institute of General Physiology, University of Ulm, Albert Einstein Allee 11, 89081 Ulm, Germany
    J Cell Sci 127:5218-27. 2014
    ..Here, we demonstrate that synaptotagmin-7 (Syt7) is expressed on lamellar bodies and links FACE and fusion pore dilation...
  13. doi Differential distribution of synaptotagmin-1, -4, -7, and -9 in rat adrenal chromaffin cells
    Hidetada Matsuoka
    Department of Cell and Systems Physiology, University of Occupational and Environmental Health School of Medicine, Kitakyushu, 807 8555, Japan
    Cell Tissue Res 344:41-50. 2011
    ..We conclude that LDCVs mainly contain Syt 7, whereas SLMVs contain Syt 1, but not Syt 7, in rat and bovine chromaffin cells...
  14. ncbi The synaptotagmins: calcium sensors for vesicular trafficking
    Motojiro Yoshihara
    The Picower Center for Learning and Memory, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Neuroscientist 10:566-74. 2004
    ..This suggests an intriguing possibility that syt 4 may mediate a postsynaptic vesicle trafficking pathway, providing a molecular basis for an evolutionarily conserved bidirectional vesicular trafficking communication system at synapses...
  15. pmc SUMOylation regulates insulin exocytosis downstream of secretory granule docking in rodents and humans
    Xiao Qing Dai
    Department of Pharmacology and Alberta Diabetes Institute, University of Alberta, Edmonton, Alberta, Canada
    Diabetes 60:838-47. 2011
    ..The reversible attachment of small ubiquitin-like modifier (SUMO) proteins controls target localization and function. We examined an acute role for the SUMOylation pathway in downstream events mediating insulin secretion...
  16. pmc Release mode of large and small dense-core vesicles specified by different synaptotagmin isoforms in PC12 cells
    Zhen Zhang
    Department of Physiology, University of Wisconsin School of Medical and Public Health, Madison, WI 53706, USA
    Mol Biol Cell 22:2324-36. 2011
    ..Thus synaptotagmin isoforms can provide multiple levels of control in the release of different molecules from the same cell...
  17. doi Silence of Synaptotagmin VII inhibits release of dense core vesicles in PC12 cells
    JiangLi Li
    Key Laboratory of Molecular Biophysics of the Ministry of Education, Institute of Biophysics and Biochemistry, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, China
    Sci China C Life Sci 52:1156-63. 2009
    b>Synaptotagmin VII (Syt VII), which has a higher Ca(2+) affinity and slower disassembly kinetics with lipid than Syt I and Syt IX, was regarded as being uninvolved in synaptic vesicle (SV) exocytosis but instead possibly as a calcium ..
  18. ncbi Identification of SNAREs involved in synaptotagmin VII-regulated lysosomal exocytosis
    Swathi K Rao
    Section of Microbial Pathogenesis and Department of Cell Biology, Yale University School of Medicine, Boyer Center for Molecular Medicine, 295 Congress Avenue, New Haven, CT 06511, USA
    J Biol Chem 279:20471-9. 2004
    ..Lysosomal exocytosis is regulated by synaptotagmin VII, a member of the synaptotagmin family of Ca2+-binding proteins localized on lysosomes...
  19. pmc Structural and mutational analysis of functional differentiation between synaptotagmins-1 and -7
    Mingshan Xue
    Department of Neuroscience, Baylor College of Medicine, Houston, Texas, United States of America
    PLoS ONE 5:. 2010
    ..Overall, our results suggest that functional differentiation in synaptotagmins arises in part from subtle sequence changes that yield dramatic functional differences...
  20. pmc Synaptotagmin 7 splice variants differentially regulate synaptic vesicle recycling
    Tuhin Virmani
    Center for Basic Neuroscience, Department of Molecular Genetics, The University of Texas Southwestern Medical Center, Dallas, TX 75390 9111, USA
    EMBO J 22:5347-57. 2003
    ..We now demonstrate that upon expression in transfected neurons, a short splice variant of synaptotagmin 7 that lacks C(2)-domains accelerates endocytic recycling of synaptic vesicles, whereas a longer splice variant ..
  21. ncbi Internalization signals in synaptotagmin VII utilizing two independent pathways are masked by intramolecular inhibitions
    Shoumita Dasgupta
    Department of Biochemistry and Biophysics, University of California San Francisco, Genentech Hall, 600 16th Street, San Francisco, California, 94143 2140, USA
    J Cell Sci 116:1327-37. 2003
    ..A related family member, synaptotagmin VII, is involved in multiple forms of regulated exocytosis of lysosomes and secretory granules...