Stat5a

Summary

Gene Symbol: Stat5a
Description: signal transducer and activator of transcription 5A
Alias: Stat5, signal transducer and activator of transcription 5A, mammary gland factor, signal transducer and activator of transcription 5
Species: rat

Top Publications

  1. ncbi Loss of Stat5a delays mammary cancer progression in a mouse model
    Shuxun Ren
    Lombardi Cancer Center, Department of Oncology, Georgetown University, Washington, DC 20007, USA
    Oncogene 21:4335-9. 2002
  2. ncbi Phospho-STAT5 accumulation in nuclear fractions from vitamin A-deficient rat liver
    Michael Murray
    Pharmacogenomics and Drug Development Group, Faculty of Pharmacy, University of Sydney, NSW 2006, Australia
    FEBS Lett 579:3669-73. 2005
  3. ncbi The JAK-STAT signaling pathway: input and output integration
    Peter J Murray
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, TN 38104, USA
    J Immunol 178:2623-9. 2007
  4. doi The Toll-like receptor 4-activated neuroprotective microglia subpopulation survives via granulocyte macrophage colony-stimulating factor and JAK2/STAT5 signaling
    Mayumi Kamigaki
    Department of Molecular and Pharmacological Neuroscience, Institute of Biomedical and Health Sciences, Hiroshima University, Hiroshima 734 8551, Japan
    Neurochem Int 93:82-94. 2016
  5. doi Impaired renal growth hormone JAK/STAT5 signaling in chronic kidney disease
    Debbie Wiezel
    Shraga Segal Department of Microbiology and Immunology, Ben Gurion University of the Negev, Beer Sheva, Israel
    Nephrol Dial Transplant 29:791-9. 2014
  6. ncbi Yin-yang 1 and glucocorticoid receptor participate in the Stat5-mediated growth hormone response of the serine protease inhibitor 2.1 gene
    P L Bergad
    Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota 55455, USA
    J Biol Chem 275:8114-20. 2000
  7. ncbi CrkL functions as a nuclear adaptor and transcriptional activator in Bcr-Abl-expressing cells
    J Rhodes
    Oregon Health Sciences University, Portland, OR 97201, USA
    Exp Hematol 28:305-10. 2000
  8. doi JANEX-1, a JAK3 inhibitor, protects pancreatic islets from cytokine toxicity through downregulation of NF-kappaB activation and the JAK/STAT pathway
    Na Lv
    Department of Biochemistry, Medical School and Diabetes Research Center, Chonbuk National University, Jeonju, Jeonbuk 561 756, Republic of Korea
    Exp Cell Res 315:2064-71. 2009
  9. pmc Suppressor of cytokine signalling-6 promotes neurite outgrowth via JAK2/STAT5-mediated signalling pathway, involving negative feedback inhibition
    Sakshi Gupta
    Eukaryotic Gene Expression Laboratory, National Institute of Immunology, New Delhi, India
    PLoS ONE 6:e26674. 2011
  10. ncbi Novel signal transduction pathway for luteinizing hormone and its interaction with insulin: activation of Janus kinase/signal transducer and activator of transcription and phosphoinositol 3-kinase/Akt pathways
    Carla R O Carvalho
    Departamento de Clinica Medica, Faculdade de Ciencias Medicas, Universidade Estadual de Campinas, 13081 970 Campinas, Brazil
    Endocrinology 144:638-47. 2003

Research Grants

Scientific Experts

  • Hanna Helander
  • G L Bratthauer
  • Michael Murray
  • Stephen T Anderson
  • Peter Murray
  • Yu Lin Yang
  • R Strange
  • A Lerant
  • Jan Xu
  • Ekaterina V Laz
  • Mayumi Kamigaki
  • Debbie Wiezel
  • Belinda J Cave
  • Julie Townsend
  • Annika Sjoeholm
  • Sakshi Gupta
  • Na Lv
  • Hong Chen
  • David J Waxman
  • Rosana D Meyer
  • Yi Hua Qian
  • Qingli Xiao
  • Keiji Isshiki
  • Hui Jin
  • Hassan Mziaut
  • Sheng Li Sun
  • Jörg Mütze
  • Yuichi Fujinaka
  • Andriana D Papaconstantinou
  • Kartik Shankar
  • Elizabeth G Snyderwine
  • Yuying C Hwang
  • Naoki Nanashima
  • Domingo J Tortonese
  • Jau Shyang Huang
  • Andrea Flynn
  • Sean Shaw
  • Mario B Marrero
  • Heather Redd
  • Liang Shan
  • Amy K Banes
  • Jingsong Cao
  • Yuhki Yanase
  • Carla R O Carvalho
  • Norio Sakai
  • Michihiro Hide
  • Yoshiki Tanaka
  • Toshihiko Shirafuji
  • Shigeru Tanaka
  • Hiroko Shiraki
  • Kana Harada
  • Takahiro Seki
  • Izumi Hide
  • Leonid Kachko
  • Orlando Morales
  • Shuxun Ren
  • Yael Segev
  • Shaonin Ji
  • Daniel Landau
  • T Kisseleva
  • Mohammed Hani Assadi
  • Ariel Troib
  • Ralph Rabkin
  • Robert S Bridges
  • Kakoli Banerjee
  • Avadhesha Surolia
  • David R Grattan
  • Kanchan Mishra
  • Greg M Anderson
  • K Gerland
  • J Rhodes
  • P L Bergad
  • L Rui
  • Chung Y Hsu
  • Mi Young Song
  • Drew Michael
  • Byung Hyun Park
  • Ha Na Choi
  • Kang Beom Kwon
  • Woo Sung Moon
  • Ting Su
  • Jianxin Bao
  • Aarathi Sugathan
  • Shawei Chen
  • Jin Woo Park
  • Sung Joo Park
  • Eun Kyung Kim
  • Nathan J Lanning
  • Gregory S White
  • Michele Solimena

Detail Information

Publications45

  1. ncbi Loss of Stat5a delays mammary cancer progression in a mouse model
    Shuxun Ren
    Lombardi Cancer Center, Department of Oncology, Georgetown University, Washington, DC 20007, USA
    Oncogene 21:4335-9. 2002
    A genetic study was conducted to determine if activated Stat5a contributes to mammary carcinogenesis and to evaluate the mechanism...
  2. ncbi Phospho-STAT5 accumulation in nuclear fractions from vitamin A-deficient rat liver
    Michael Murray
    Pharmacogenomics and Drug Development Group, Faculty of Pharmacy, University of Sydney, NSW 2006, Australia
    FEBS Lett 579:3669-73. 2005
    ..Nuclear tyrosine- and serine-phosphorylated STAT5 accumulated in VAD liver, whereas nuclear JAK2 tyrosine kinase and SHP-1 phosphatase were decreased...
  3. ncbi The JAK-STAT signaling pathway: input and output integration
    Peter J Murray
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, TN 38104, USA
    J Immunol 178:2623-9. 2007
    ..New data suggests that SOCS proteins introduce additional diversity into the JAK-STAT pathway by adjusting the output of activated STATs that alters downstream gene activation...
  4. doi The Toll-like receptor 4-activated neuroprotective microglia subpopulation survives via granulocyte macrophage colony-stimulating factor and JAK2/STAT5 signaling
    Mayumi Kamigaki
    Department of Molecular and Pharmacological Neuroscience, Institute of Biomedical and Health Sciences, Hiroshima University, Hiroshima 734 8551, Japan
    Neurochem Int 93:82-94. 2016
    ..As for the GM-CSFR downstream signal, LPS resulted in the phosphorylation of STAT5 and its translocation to the nucleus in the surviving microglia...
  5. doi Impaired renal growth hormone JAK/STAT5 signaling in chronic kidney disease
    Debbie Wiezel
    Shraga Segal Department of Microbiology and Immunology, Ben Gurion University of the Negev, Beer Sheva, Israel
    Nephrol Dial Transplant 29:791-9. 2014
    ..However, concerns have been raised on the potential renal fibrogenic effects of GH. There is no information regarding the renal GH receptor (GHR)-JAK-STAT signaling pathway in CKD...
  6. ncbi Yin-yang 1 and glucocorticoid receptor participate in the Stat5-mediated growth hormone response of the serine protease inhibitor 2.1 gene
    P L Bergad
    Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota 55455, USA
    J Biol Chem 275:8114-20. 2000
    ..1, was found to contain Stat5a and -5b, as well as additional components...
  7. ncbi CrkL functions as a nuclear adaptor and transcriptional activator in Bcr-Abl-expressing cells
    J Rhodes
    Oregon Health Sciences University, Portland, OR 97201, USA
    Exp Hematol 28:305-10. 2000
    ..To identify tyrosine phosphorylated proteins that interact with CrkL in Bcr-Abl-expressing cells and analyze the function of that association...
  8. doi JANEX-1, a JAK3 inhibitor, protects pancreatic islets from cytokine toxicity through downregulation of NF-kappaB activation and the JAK/STAT pathway
    Na Lv
    Department of Biochemistry, Medical School and Diabetes Research Center, Chonbuk National University, Jeonju, Jeonbuk 561 756, Republic of Korea
    Exp Cell Res 315:2064-71. 2009
    ....
  9. pmc Suppressor of cytokine signalling-6 promotes neurite outgrowth via JAK2/STAT5-mediated signalling pathway, involving negative feedback inhibition
    Sakshi Gupta
    Eukaryotic Gene Expression Laboratory, National Institute of Immunology, New Delhi, India
    PLoS ONE 6:e26674. 2011
    ..But no reports are available about the role of SOCS6 in neuritogenesis. In this study, we examined the role of SOCS6 in neurite outgrowth and neuronal cell signalling...
  10. ncbi Novel signal transduction pathway for luteinizing hormone and its interaction with insulin: activation of Janus kinase/signal transducer and activator of transcription and phosphoinositol 3-kinase/Akt pathways
    Carla R O Carvalho
    Departamento de Clinica Medica, Faculdade de Ciencias Medicas, Universidade Estadual de Campinas, 13081 970 Campinas, Brazil
    Endocrinology 144:638-47. 2003
    ..These results indicate a new signal transduction pathway for LH and show that there is positive cross-talk between the insulin and LH signaling pathways at the level of phosphoinositol 3-kinase/AKT pathway in this tissue...
  11. pmc Differential binding to and regulation of JAK2 by the SH2 domain and N-terminal region of SH2-bbeta
    L Rui
    Department of Physiology, University of Michigan Medical School, Ann Arbor, Michigan 48109 0622, USA
    Mol Cell Biol 20:3168-77. 2000
    ..This would result in a more rapid and robust cellular response to hormones and cytokines that activate JAK2. This interaction between inactive JAK2 and SH2-B may also help prevent abnormal activation of JAK2...
  12. ncbi Modulation of signal transducers and activators of transcription (STAT) factor pathways during focal cerebral ischaemia: a gene expression array study in rat hippocampus after middle cerebral artery occlusion
    Sheng Li Sun
    Department of Pharmacology, School of Pharmacy, Second Military Medical University, Shanghai, China
    Clin Exp Pharmacol Physiol 34:1097-101. 2007
    ....
  13. ncbi Mechanisms underlying the diminished sensitivity to prolactin negative feedback during lactation: reduced STAT5 signaling and up-regulation of cytokine-inducible SH2 domain-containing protein (CIS) expression in tuberoinfundibular dopaminergic neurons
    Stephen T Anderson
    School of Biomedical Sciences, The University of Queensland, Queensland 4072, Australia
    Endocrinology 147:1195-202. 2006
    ..Dual-label confocal immunofluorescence studies were used to determine the intracellular distribution of STAT5 within TIDA neurons in the dorsomedial arcuate nucleus...
  14. ncbi Lactogens promote beta cell survival through JAK2/STAT5 activation and Bcl-XL upregulation
    Yuichi Fujinaka
    Division of Endocrinology, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    J Biol Chem 282:30707-17. 2007
    ..this protective effect is the janus-activated-kinase-2/signal transducer and activator of transcription-5 (JAK2/STAT5) pathway...
  15. ncbi Proliferation and apoptosis in mammary epithelium during the rat oestrous cycle
    R Strange
    Division of Medical Oncology, University of Colorado Health Sciences Center, Denver, CO 80214, USA
    Acta Physiol (Oxf) 190:137-49. 2007
    ..To understand the processes resulting in these changes, particularly the regulation of cell death, we examined protein levels in mammary epithelium during the oestrous cycle of the Sprague-Dawley rat...
  16. ncbi Nuclear translocation of the transcription factor STAT5 in the rat brain after systemic leptin administration
    Jörg Mütze
    Department of Veterinary Physiology, Justus Liebig University Giessen, Frankfurter Strasse 100, D 35392 Giessen, Germany
    Neurosci Lett 417:286-91. 2007
    ..time that systemic treatment with leptin (5 mg/kg; intraperitoneal injection) also increased the number of nuclear STAT5 signals in the hypothalamus...
  17. ncbi Proliferation and apoptosis in PhIP-induced rat mammary gland carcinomas with elevated phosphotyrosine-STAT5a
    Andriana D Papaconstantinou
    Chemical Carcinogenesis Section, Laboratory of Experimental Carcinogenesis, National Cancer Institute, NIH, Bethesda, MD 20892, USA
    FEBS Lett 581:29-33. 2007
    ..mammary gland carcinomas were different between carcinomas with high and low expression of phosphotyrosine (pY)-STAT5a. We determined that carcinomas with high pY-STAT5a were more proliferative (MIB5 immunostaining) and had a higher ..
  18. ncbi Physiologic and genomic analyses of nutrition-ethanol interactions during gestation: Implications for fetal ethanol toxicity
    Kartik Shankar
    Department of Pharmacology and Toxicology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
    Exp Biol Med (Maywood) 231:1379-97. 2006
    ..0005). Examination of maternal GH signaling via STAT5a and -5b revealed significant reduction in both gene and protein expression produced by both EtOH and ..
  19. ncbi Prolactin-induced activation of STAT5 within the hypothalamic arcuate nucleus
    Belinda J Cave
    Department of Anatomy, University of Bristol, Bristol, UK
    Neuroreport 16:1423-6. 2005
    ..Following exogenous prolactin treatment, phosphorylation of STAT5 (signal transducer and activator of transcription) within the arcuate nucleus was measured using a highly ..
  20. pmc ICA512 signaling enhances pancreatic beta-cell proliferation by regulating cyclins D through STATs
    Hassan Mziaut
    Department of Experimental Diabetology, Center for Regenerative Therapies Dresden, School of Medicine, Dresden University of Technology, 01307 Dresden, Germany
    Proc Natl Acad Sci U S A 105:674-9. 2008
    ..resulting cytosolic fragment (ICA512-CCF) moves into the nucleus where it enhances the levels of phosphorylated STAT5 and STAT3, thereby inducing insulin gene transcription and granule biogenesis...
  21. pmc JAK2, but not Src family kinases, is required for STAT, ERK, and Akt signaling in response to growth hormone in preadipocytes and hepatoma cells
    Hui Jin
    Department of Molecular and Integrative Physiology, The University of Michigan Medical School, Ann Arbor, Michigan 48109 5622, USA
    Mol Endocrinol 22:1825-41. 2008
    ..These results strongly suggest that JAK2, but not Src family kinases, is critical for transducing these GH signals in 3T3-F442A and H4IIE cells...
  22. pmc Insulin regulates SOCS2 expression and the mitogenic effect of IGF-1 in mesangial cells
    Keiji Isshiki
    Research Division, Joslin Diabetes Center, One Joslin Place, Harvard Medical School, Boston, Massachusetts 02215, USA
    Kidney Int 74:1434-43. 2008
    ..growth factor 1 receptor (IGF-1R) were increased while those of suppressor of cytokine signaling 2 (SOCS2) and STAT5 were decreased. All of these changes were normalized by islet cell transplantation...
  23. pmc STAT5 mediates antiapoptotic effects of methylprednisolone on oligodendrocytes
    Jan Xu
    Department of Neurology, Center for Aging, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Neurosci 29:2022-6. 2009
    ..Based on published findings of the functional interactions between GR and STAT5, a transcription factor from the family of signal transducers and activators of transcription (STAT), we examined ..
  24. pmc Dexamethasone inhibits camptothecin-induced apoptosis in C6-glioma via activation of Stat5/Bcl-xL pathway
    Yi Hua Qian
    Department of Human Anatomy and Histology Embryology, School of Medicine, Xi an Jiaotong University, Xi an, People s Republic of China
    Biochim Biophys Acta 1793:764-71. 2009
    ..gene, Bcl-xL expression, and its transcription factor, signaling transducer and activator of transcription 5 (Stat5), DNA binding activity and phospho-Stat5 expression...
  25. pmc Dynamic in vivo binding of STAT5 to growth hormone-regulated genes in intact rat liver. Sex-specific binding at low- but not high-affinity STAT5 sites
    Ekaterina V Laz
    Division of Cell and Molecular Biology, Department of Biology, Boston University, Boston, Massachusetts 02215, USA
    Mol Endocrinol 23:1242-54. 2009
    ..upstream (100 kb) and downstream regions (25 kb), was aligned across four species and searched for conserved STAT5-binding sites using TFBS matrices...
  26. pmc Male-specific hepatic Bcl6: growth hormone-induced block of transcription elongation in females and binding to target genes inversely coordinated with STAT5
    Rosana D Meyer
    Division of Cell and Molecular Biology, Department of Biology, Boston University, Boston, Massachusetts 02215, USA
    Mol Endocrinol 23:1914-26. 2009
    ..Indeed, STAT5 was bound to Bcl6 STAT5-binding region-B, previously associated with Bcl6 repression, in both male and female ..
  27. pmc Region-, neuron-, and signaling pathway-specific increases in prolactin responsiveness in reproductively experienced female rats
    Annika Sjoeholm
    Centre for Neuroendocrinology and Department of Anatomy and Structural Biology, University of Otago School of Medical Sciences, Dunedin, New Zealand
    Endocrinology 152:1979-88. 2011
    ..The brains underwent immunohistochemistry for the phosphorylated forms of signal transducer and activator of transcription 5 (pSTAT5) or ERK1/2 (pERK1/2)...
  28. ncbi Growth hormone-induced differential desensitization of STAT5, ERK, and Akt phosphorylation
    Shaonin Ji
    Department of Pathology, Division of Molecular and Cellular Pathology, University of Alabama at Birmingham, and the Birmingham Veterans Affairs Medical Center, Birmingham, Alabama 35294, USA
    J Biol Chem 277:28384-93. 2002
    ..both of which are required for male-specific pattern of liver gene expression and GH-induced phosphorylation of STAT5. The present study suggests that regulation of GH receptor (GHR) levels in rat hepatoma cells by repeated GH ..
  29. ncbi Transcription factors Stat3 and Stat5b are present in rat liver nuclei late in an acute phase response and bind interleukin-6 response elements
    J A Ripperger
    Chair of Genetics, University of Erlangen Nurnberg, Federal Republic of Germany
    J Biol Chem 270:29998-30006. 1995
    ..The amino acid sequence of rat Stat5b showed 26.7% overall identity with rat Stat3, 87.3% with sheep Stat5a, 92.5% with murine Stat5a, and 98.7% with murine Stat5b.
  30. ncbi Regulation of mammary gland factor/Stat5a during mammary gland development
    A V Kazansky
    Department of Cell Biology, Baylor College of Medicine, Houston, Texas 77030 3498, USA
    Mol Endocrinol 9:1598-609. 1995
    The rat homolog of sheep mammary gland factor (MGF)/Stat5 has been isolated and used to study the regulation of Stat5 during mammary gland development and PRL regulation in COS cells transfected with Stat5a and the PRL receptor...
  31. ncbi Identification of genomic regions controlling experimental autoimmune uveoretinitis in rats
    S H Sun
    Laboratory of Immunology, National Eye Institute, NIH, Bethesda, MD 20892, USA
    Int Immunol 11:529-34. 1999
    ..Further analysis of these genomic regions may lead to identification of the susceptibility genes and to characterization of their function...
  32. ncbi Activation of the Jak/Stat signal transduction pathway in GH-treated rat osteoblast-like cells in culture
    K Gerland
    Laboratoire d Histologie Embryologie LHEA, UFR des sciences médicales, 1, Rue Haute de Reculee, 49045 cedex, Angers, France
    Mol Cell Endocrinol 168:1-9. 2000
    ..The results show a GH-induced and sustained phosphorylation of Jak2 and Stat5 on tyrosine residues. The tyrosine phosphorylation status of Jak2 was increased in a dose-dependent manner...
  33. ncbi Nuclear translocation of STAT5 and increased expression of Fos related antigens (FRAs) in hypothalamic dopaminergic neurons after prolactin administration
    A Lerant
    Department of Anatomy, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS 39215 4505, USA
    Brain Res 904:259-69. 2001
    ..We used nuclear translocation of STAT5 as a marker of prolactin receptor induced signaling and expression of Fos related antigens (FRAs) as an indicator ..
  34. ncbi Signaling through the JAK/STAT pathway, recent advances and future challenges
    T Kisseleva
    Department of Microbiology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Gene 285:1-24. 2002
    ..Similarly, the solution of the crystal structure of two STATs has and will continue to facilitate our understanding of how STATs function. This review will highlight these exciting developments in JAK/STAT signaling...
  35. ncbi Possible involvement of truncated signal transducer and activator of transcription-5 in the GH pattern-dependent regulation of CYP2C12 gene expression in rat liver
    Hanna Helander
    Department of Medical Nutrition, Karolinska Institutet, Novum, S 141 86 Huddinge, Sweden
    Mol Endocrinol 16:1598-611. 2002
    ..extracts to this site involved simultaneous binding of two Stat5 dimers, most likely both Stat5b homodimers and Stat5a/Stat5b heterodimers...
  36. ncbi 1Alpha,25-dihydroxyvitamin D3 inhibits GH-induced expression of SOCS-3 and CIS and prolongs growth hormone signaling via the Janus kinase (JAK2)/signal transducers and activators of transcription (STAT5) system in osteoblast-like cells
    Orlando Morales
    Department of Orthopedic Surgery, Karolinska Institutet, Huddinge Hospital, S 141 86 Huddinge, Sweden
    J Biol Chem 277:34879-84. 2002
    ..GH mainly activates JAK2 and STAT5a and b...
  37. ncbi Nuclear localization of STAT5A modified with O-linked N-acetylglucosamine and early involution in the mammary gland of Hirosaki hairless rat
    Naoki Nanashima
    Second Department of Biochemistry, Hirosaki University School of Medicine, Hirosaki 036 8562, Japan
    J Biol Chem 280:43010-6. 2005
    ..Nuclear localization of STAT5A in HHR and SDR was confirmed by immunohistochemistry...
  38. ncbi Angiotensin II blockade prevents hyperglycemia-induced activation of JAK and STAT proteins in diabetic rat kidney glomeruli
    Amy K Banes
    Vascular Biology Ctr, Medical College of Georgia, Augusta, GA 30912 2500, USA
    Am J Physiol Renal Physiol 286:F653-9. 2004
    ..STZ stimulated glomerular phosphorylation of JAK2, STAT1, STAT3, and STAT5. Phosphorylation was reduced in rats treated with captopril, candesartan, and AG-490...
  39. ncbi Estradiol represses prolactin-induced expression of Na+/taurocholate cotransporting polypeptide in liver cells through estrogen receptor-alpha and signal transducers and activators of transcription 5a
    Jingsong Cao
    Graduate Center for Toxicology, Department of Physiology, Chandler Medical Center, University of Kentucky, Lexington 40536 0305, USA
    Endocrinology 145:1739-49. 2004
    ..shift analysis revealed that E(2)-bound ERalpha decreased the tyrosine phosphorylation and DNA-binding activity of Stat5a, indicating that the inhibitory effect of E(2) was mediated, at least in part, by interfering with PRL-mediated ..
  40. ncbi Possible role of Stat5a in rat mammary gland carcinogenesis
    Liang Shan
    Chemical Carcinogenesis Section, Laboratory of Experimental Carcinogenesis, CCR, NCI, Building 37, Room 4146, 37 Convent Dr, Bethesda, MD, 20892 4262, USA
    Breast Cancer Res Treat 88:263-72. 2004
    ..In the mammary gland, Stat5a is well recognized for its function in prolactin signaling, lobuloalveolar development, and milk protein ..
  41. ncbi Aldose reductase pathway mediates JAK-STAT signaling: a novel axis in myocardial ischemic injury
    Yuying C Hwang
    Division of Surgical Science, Department of Surgery, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    FASEB J 19:795-7. 2005
    ..Induction of global ischemia in rats resulted in JAK2 activation followed by STAT5 activation...
  42. ncbi Effects of prolactin on hypothalamic supraoptic neurones: evidence for modulation of STAT5 expression and electrical activity
    Julie Townsend
    Department of Anatomy, University of Bristol, Pre clinical Veterinary School, Southwell St, Bristol, BS2 8EJ, UK
    Neuro Endocrinol Lett 26:125-30. 2005
    The study investigated the role of prolactin (PRL) in modulating STAT5 and electrical activity of magnocellular neurones in the supraoptic (SO) nucleus of male rats.
  43. ncbi Effect of nitric oxide-cGMP-dependent protein kinase activation on advanced glycation end-product-induced proliferation in renal fibroblasts
    Jau Shyang Huang
    Department of Biological Science and Technology, Chung Hwa College of Medical Technology, 89 Wen Hwa, 1st Street, Jen Te Hsiang, Tainan Hsien 717, Taiwan, Republic of China
    J Am Soc Nephrol 16:2318-29. 2005
    ..both AGE-induced proliferation and Janus kinase 2 (JAK2)-signal transducers and activators of transcription 5 (STAT5) activation but not p42/p44 mitogen-activated protein kinase (MAPK) activation...
  44. pmc Mammary gland factor (MGF) is a novel member of the cytokine regulated transcription factor gene family and confers the prolactin response
    H Wakao
    Friedrich Miescher Institute, Basel, Switzerland
    EMBO J 13:2182-91. 1994
    ..The mammary gland factor, MGF, has been shown to be a central mediator in the lactogenic hormone response...
  45. ncbi STAT 5a expression in various lesions of the breast
    Gary L Bratthauer
    Department of Gynecologic and Breast Pathology, Armed Forces Institute of Pathology, Washington, DC 20306 6000, USA
    Virchows Arch 448:165-71. 2006
    ..The absence of STAT 5a in the abnormal breast epithelial cells may indicate a defect contributory to the abnormal state...

Research Grants2

  1. Role of SOCS proteins in host-pathogen responses
    Peter Murray; Fiscal Year: 2003
    ..PERFORMANCE SITE (S) (organization, city, state) St. Jude Children's Research Hospital, Memphis, TN . ..
  2. Role of Macrophage Arginase in Anti-Bacterial Immunity
    Peter Murray; Fiscal Year: 2009
    ..The outcomes of the proposed studies will reveal new elements of Arg I function and provide rationale for approaching Arg I as a target in inflammatory diseases. ..