Sst

Summary

Gene Symbol: Sst
Description: somatostatin
Alias: SS-14, SS-28, Smst, somatostatin
Species: rat

Top Publications

  1. pmc Neuronostatin acts via GPR107 to increase cAMP-independent PKA phosphorylation and proglucagon mRNA accumulation in pancreatic α-cells
    Mollisa M Elrick
    Department of Pharmacological and Physiological Science, Saint Louis University School of Medicine, St Louis, Missouri
    Am J Physiol Regul Integr Comp Physiol 310:R143-55. 2016
  2. ncbi An intracellular multi-effector complex mediates somatostatin receptor 1 activation of phospho-tyrosine phosphatase eta
    Sara Arena
    Section of Pharmacology, Department of Oncology, Biology and Genetics, Univertsity of Genova 16132 Genova, Italy
    Mol Endocrinol 21:229-46. 2007
  3. ncbi Somatostatin and gamma-aminobutyric acid inhibit interleukin-1 beta-stimulated release of interleukin-6 from rat C6 glioma cells
    Bryan L Spangelo
    Department of Chemistry, University of Nevada at Las Vegas, Las Vegas, NV 89154 4003, USA
    Neuroimmunomodulation 11:332-40. 2004
  4. ncbi Immunohistochemical expression and colocalization of somatostatin, carboxypeptidase-E and prohormone convertases 1 and 2 in rat brain
    S Billova
    Faculty of Pharmaceutical Sciences, Department of Pharmacology and Toxicology, University of British Columbia, Vancouver, BC, Canada V6T 124
    Neuroscience 147:403-18. 2007
  5. doi Synaptic relationship between somatostatin- and neurokinin-1 receptor-immunoreactive neurons in the pre-Bötzinger complex of rats
    Xiao Yan Wei
    Institute of Neurosciences, The Fourth Military Medical University, Xi an, China
    J Neurochem 122:923-33. 2012
  6. pmc Agonist-biased trafficking of somatostatin receptor 2A in enteric neurons
    Peishen Zhao
    Monash Institute of Pharmaceutical Sciences, 381 Royal Parade, Parkville, Victoria 3052, Australia
    J Biol Chem 288:25689-700. 2013
  7. doi Somatostatin enhances tooth-pulp-evoked cervical dorsal horn neuronal activity in the rat via inhibition of GABAergic interneurons
    Masayuki Takahashi
    Department of Physiology, School of Life Dentistry at Tokyo, Nippon Dental University, 1 9 20, Fujimi, Chiyoda ku, Tokyo 102 8159, Japan Electronic address
    Brain Res Bull 100:76-83. 2014
  8. ncbi The role of C-Fos protein, somatostatin and neuropeptide Y in the pathogenesis of ischemic brain injuries based on animal model of cerebral ischemia
    Aleksandar A Jovanović
    University of Belgrade, School of Medicine, Belgrade, Serbia
    Coll Antropol 37:847-52. 2013
  9. doi Colocalization of cannabinoid receptor 1 with somatostatin and neuronal nitric oxide synthase in rat brain hippocampus
    Shenglong Zou
    Faculty of Pharmaceutical Sciences, The University of British Columbia, Vancouver, BC, Canada
    Brain Res 1622:114-26. 2015
  10. doi Somatostatin receptor-mediated suppression of gabaergic synaptic transmission in cultured rat retinal amacrine cells
    W Chen
    Institutes of Brain Science, Institute of Neurobiology and State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai 200032, China
    Neuroscience 273:118-27. 2014

Scientific Experts

Detail Information

Publications70

  1. pmc Neuronostatin acts via GPR107 to increase cAMP-independent PKA phosphorylation and proglucagon mRNA accumulation in pancreatic α-cells
    Mollisa M Elrick
    Department of Pharmacological and Physiological Science, Saint Louis University School of Medicine, St Louis, Missouri
    Am J Physiol Regul Integr Comp Physiol 310:R143-55. 2016
    Neuronostatin (NST) is a recently described peptide that is produced from the somatostatin preprohormone in pancreatic δ-cells...
  2. ncbi An intracellular multi-effector complex mediates somatostatin receptor 1 activation of phospho-tyrosine phosphatase eta
    Sara Arena
    Section of Pharmacology, Department of Oncology, Biology and Genetics, Univertsity of Genova 16132 Genova, Italy
    Mol Endocrinol 21:229-46. 2007
    ..Here we characterize, in Chinese hamster ovary-k1 cells, the intracellular pathway that from somatostatin receptor 1 (SSTR1), leads to the activation of PTPeta and that involves, in a multimeric complex and sequential ..
  3. ncbi Somatostatin and gamma-aminobutyric acid inhibit interleukin-1 beta-stimulated release of interleukin-6 from rat C6 glioma cells
    Bryan L Spangelo
    Department of Chemistry, University of Nevada at Las Vegas, Las Vegas, NV 89154 4003, USA
    Neuroimmunomodulation 11:332-40. 2004
    ..We investigated the ability of inhibitory neurotransmitters to alter the interleukin-1 beta (IL-1 beta)-stimulated release of interleukin-6 (IL-6) from cultured glial tumor cells...
  4. ncbi Immunohistochemical expression and colocalization of somatostatin, carboxypeptidase-E and prohormone convertases 1 and 2 in rat brain
    S Billova
    Faculty of Pharmaceutical Sciences, Department of Pharmacology and Toxicology, University of British Columbia, Vancouver, BC, Canada V6T 124
    Neuroscience 147:403-18. 2007
    ..CPE), prohormone convertase 1 (PC1) and prohormone convertase 2 (PC2) may function as sorting elements for somatostatin (SST) for its maturation and processing to appropriate targets...
  5. doi Synaptic relationship between somatostatin- and neurokinin-1 receptor-immunoreactive neurons in the pre-Bötzinger complex of rats
    Xiao Yan Wei
    Institute of Neurosciences, The Fourth Military Medical University, Xi an, China
    J Neurochem 122:923-33. 2012
    ..b>Somatostatin (SST) and neurokinin 1 receptor (NK1R) immunoreactivity have been used as markers of the pre-BötC...
  6. pmc Agonist-biased trafficking of somatostatin receptor 2A in enteric neurons
    Peishen Zhao
    Monash Institute of Pharmaceutical Sciences, 381 Royal Parade, Parkville, Victoria 3052, Australia
    J Biol Chem 288:25689-700. 2013
    b>Somatostatin (SST) 14 and SST 28 activate somatostatin 2A receptors (SSTR2A) on enteric neurons to control gut functions...
  7. doi Somatostatin enhances tooth-pulp-evoked cervical dorsal horn neuronal activity in the rat via inhibition of GABAergic interneurons
    Masayuki Takahashi
    Department of Physiology, School of Life Dentistry at Tokyo, Nippon Dental University, 1 9 20, Fujimi, Chiyoda ku, Tokyo 102 8159, Japan Electronic address
    Brain Res Bull 100:76-83. 2014
    ..analysis combined with anatomical approach suggests that a potential disinhibitory mechanism involving somatostatin (SST), which is released by interneurons in the superficial dorsal horn, contributes to nociceptive ..
  8. ncbi The role of C-Fos protein, somatostatin and neuropeptide Y in the pathogenesis of ischemic brain injuries based on animal model of cerebral ischemia
    Aleksandar A Jovanović
    University of Belgrade, School of Medicine, Belgrade, Serbia
    Coll Antropol 37:847-52. 2013
    ..this study was to define all the areas of changes in expression of nuclear c-Fos protein (c-Fos), cytoplasmic somatostatin (SS) and neuropeptide Y (NPY) in rat brain during experimental ischemia...
  9. doi Colocalization of cannabinoid receptor 1 with somatostatin and neuronal nitric oxide synthase in rat brain hippocampus
    Shenglong Zou
    Faculty of Pharmaceutical Sciences, The University of British Columbia, Vancouver, BC, Canada
    Brain Res 1622:114-26. 2015
    b>Somatostatin (SST), a growth hormone inhibitory peptide, is expressed in different parts of the brain and functions as a neurotransmitter and neuromodulator...
  10. doi Somatostatin receptor-mediated suppression of gabaergic synaptic transmission in cultured rat retinal amacrine cells
    W Chen
    Institutes of Brain Science, Institute of Neurobiology and State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai 200032, China
    Neuroscience 273:118-27. 2014
    b>Somatostatin (SRIF) modulates neurotransmitter release by activating the specific receptors (sst1-sst5). Our previous study showed that sst5 receptors are expressed in rat retinal GABAergic amacrine cells...
  11. doi H. pylori acutely inhibits gastric secretion by activating CGRP sensory neurons coupled to stimulation of somatostatin and inhibition of histamine secretion
    Muhammad Zaki
    Department of Medicine, Virginia Commonwealth University s Medical College of Virginia, Richmond, VA, USA
    Am J Physiol Gastrointest Liver Physiol 304:G715-22. 2013
    ..cfu/ml) or spent broth alone (1:10(5) to 1:10(0) final dilution) caused a concentration-dependent increase in somatostatin (SST; maximal: 200 ± 20 and 194 ± 9% above basal; P < 0...
  12. pmc Comparison of the activation of somatostatin- and neuropeptide Y-containing neuronal populations of the rat amygdala following two different anxiogenic stressors
    Ryan K Butler
    Department of Pharmacology, Physiology and Neuroscience, University of South Carolina School of Medicine, Columbia, SC 29208, USA
    Exp Neurol 238:52-63. 2012
    ..of the brains were prepared for dual-labeled immunohistochemistry and counts of c-Fos co-localized with somatostatin (SOM) or neuropeptide Y (NPY) were made in the basolateral (BLA), central (CEA), medial (MEA) nuclei of the ..
  13. pmc Somatostatin and neuropeptide Y neurons undergo different plasticity in parahippocampal regions in kainic acid-induced epilepsy
    Meinrad Drexel
    Department of Pharmacology, Innsbruck Medical University, Innsbruck, Austria
    J Neuropathol Exp Neurol 71:312-29. 2012
    ..Using immunohistochemistry and in situ hybridization for somatostatin and neuropeptide Y, we investigated plastic morphologic and neurochemical changes in parahippocampal neurons in ..
  14. pmc Neuronostatin, a novel peptide encoded by somatostatin gene, regulates cardiac contractile function and cardiomyocyte survival
    Laura Vainio
    Dept of Pharmacology and Toxicology, Institute of Biomedicine, University of Oulu, P O Box 5000, FIN 90014 Oulu, Finland
    J Biol Chem 287:4572-80. 2012
    Neuronostatin, a recently discovered peptide encoded by somatostatin gene, is involved in regulation of neuronal function, blood pressure, food intake, and drinking behavior...
  15. doi Somatostatin inhibition of GnRH neuronal activity and the morphological relationship between GnRH and somatostatin neurons in rats
    Makiko Koyama
    Department of Physiology, Nippon Medical School, 1 Sendagi, Bunkyo, Tokyo 113 8602, Japan
    Endocrinology 153:806-14. 2012
    ..activity of GnRH neurons is regulated by a variety of bioactive substances, including the inhibitory peptide somatostatin. In the present study, we focused on somatostatin because intracerebroventricular injection of somatostatin ..
  16. pmc The melanocortins, not oxytocin, mediate the anorexigenic and antidipsogenic effects of neuronostatin
    Gina L C Yosten
    Department of Pharmacological and Physiological Science, Saint Louis University School of Medicine, 1402 S Grand Boulevard, Saint Louis, MO 63104, USA
    Peptides 31:1711-4. 2010
    Neuronostatin, a recently discovered peptide derived from the somatostatin preprohormone, significantly inhibited both food and water intake when administered centrally in adult male rats...
  17. ncbi An immunohistochemical study of endocrine cells in the stomach of hypertensive rats
    I Kasacka
    Department of Histology and Embryology, Medical University of Białystok, Poland
    J Physiol Pharmacol 58:469-78. 2007
    ..The effect of spontaneous hypertension on the distribution and occurrence of somatostatin-, gastrin- and serotonin-immunoreactive cells in the fundus and pylorus of the rat stomach was examined by ..
  18. doi Inhibitory effect of somatostatin on prostaglandin E2 synthesis by primary neonatal rat glial cells
    Naama Dror
    Department of Clinical Pharmacology, Ben Gurion University of the Negev, P O B 653 Beer Sheva, 84105, Israel
    Regul Pept 150:21-5. 2008
    Glial inflammation plays an integral role in the development of neurodegenerative disease. Although somatostatin is known to be a local anti-inflammatory factor in the periphery, evidence of a similar function in the brain is scarce...
  19. doi NPY-, SOM- and VIP-containing interneurons in postnatal development of the rat claustrum
    Przemysław Kowiański
    Department of Anatomy and Neurobiology, Medical University of Gdansk, 1 Debinki Street, 80 211 Gdansk, Poland
    Brain Res Bull 76:565-71. 2008
    ..The postnatal development of neuropeptide Y-, somatostatin- and vasoactive intestinal polypeptide-containing interneurons was studied during the 4 postnatal months (P0-..
  20. doi Somatostatin in medium-sized aspiny interneurons of striatum is responsible for their preservation in quinolinic acid and N-methyl-D-asparate-induced neurotoxicity
    Ujendra Kumar
    Division of Pharmacology and Toxicology, Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, Canada
    J Mol Neurosci 35:345-54. 2008
    b>Somatostatin (SST) is a multifunctional peptide and involves in several neurodegenerative diseases...
  21. pmc Somatostatin in the rat periventricular nucleus: sex differences and effect of gonadal steroids
    Harmke H Van Vugt
    Human and Animal Physiology Group, Wageningen University, 6709 PG, Wageningen, The Netherlands
    Exp Brain Res 188:483-91. 2008
    ..in growth hormone release is driven by sex steroids, and is suggested to result mainly from differences in somatostatin (SOM) release patterns from the median eminence...
  22. pmc Activation of GIRK channels in substantia gelatinosa neurones of the adult rat spinal cord: a possible involvement of somatostatin
    Terumasa Nakatsuka
    Department of Physiology, Faculty of Medicine, Saga University, Saga 849 8501, Japan
    J Physiol 586:2511-22. 2008
    ..b>Somatostatin produced an outward current in a subpopulation of SG neurones and the slow IPSC was occluded during the ..
  23. ncbi Growth hormone and somatostatin directly inhibit gastric ghrelin secretion. An in vitro organ culture system
    L M Seoane
    Molecular Endocrinology, Investigation Area, Complejo Hospitalario Universitario de Santiago de Compostela CHUS, PO Box 563, E 15780, Santiago de Compostela, Spain
    J Endocrinol Invest 30:RC22-5. 2007
    ..These results would confirm the capacity of GH and SS to act directly upon gastric level, inhibiting ghrelin secretion in vitro...
  24. ncbi [Effect of Bnxia Xexin Decoction and its disassembled recipes on somatostatin in rats with stress gastric ulcer]
    Zhong Zhang
    Department of Human Morphology, Basic Theory College, Beijing University of Chinese Medicine, Beijing
    Zhongguo Zhong Xi Yi Jie He Za Zhi 27:916-8. 2007
    ..To explore the acting mechanism of Banxia Xiexin Decoction (BXD) and its disassembled recipes on stress gastric ulcer, for providing references to the scientific researches on the assembling rule of BXD...
  25. ncbi Dopamine (D1) receptor activation and nitrinergic agents influence somatostatin levels in rat retina
    Foteini Kiagiadaki
    Laboratory of Pharmacology, Department of Basic Sciences, Faculty of Medicine, University of Crete, Heraklion, Crete 71110 GR, Greece
    Exp Eye Res 86:18-24. 2008
    b>Somatostatin (SRIF) influences the release of two important neuromodulators of retinal circuitry, dopamine (DA) and nitric oxide (NO)...
  26. ncbi Molecular and cellular characterization of the age-related neuroinflammatory processes occurring in normal rat hippocampus: potential relation with the loss of somatostatin GABAergic neurons
    M Paz Gavilan
    Departamento de Bioquimica, Bromatologia, Toxicologia y Medicina Legal, Facultad de Farmacia, Universidad de Sevilla, Sevilla, Spain
    J Neurochem 103:984-96. 2007
    ..The mRNA expression of somatostatin, a neuropeptide expressed by some GABAergic interneurons, and the number of somatostatin-immunopositive cells ..
  27. doi Intracellular degradation of somatostatin-14 following somatostatin-receptor3-mediated endocytosis in rat insulinoma cells
    Dirk Roosterman
    Department of Dermatology, IZKF Münster and Ludwig Boltzmann Institute for Cell and Immunobiology of the Skin, Germany
    FEBS J 275:4728-39. 2008
    b>Somatostatin receptor (SSTR) endocytosis influences cellular responsiveness to agonist stimulation and somatostatin receptor scintigraphy, a common diagnostic imaging technique...
  28. doi Effect of obestatin on insulin, glucagon and somatostatin secretion in the perfused rat pancreas
    Eva M Egido
    Department of Physiology, Medical School, Universidad Autonoma de Madrid, San Martin de Porres 4, 28035 Madrid, Spain
    Regul Pept 152:61-6. 2009
    ..Obestatin failed to significantly modify the glucagon and somatostatin responses to arginine, indicating that its stimulation of insulin output is not mediated by an alpha- or delta-..
  29. ncbi [Effect of rheum on gastrointestinal hormones in rats with severe scald injury]
    Xing Guo
    Department of Burns and Plastic Surgery, Affiliated Hospital of Luzhou Medical College, Luzhou 646000, PR China
    Zhonghua Shao Shang Za Zhi 24:111-3. 2008
    To observe the changes in motilin (MTL), substance P (SP), vasoactive intestinal peptide (VIP) and somatostatin (SS) in plasma of rats with severe scald injury at early stage and the effect of rheum on their changes.
  30. doi Antidepressants influence somatostatin levels and receptor pharmacology in brain
    Eleftherios Pallis
    Department of Basic Sciences, Laboratory of Pharmacology, Faculty of Medicine, University of Crete, Heraklion, Crete, Greece
    Neuropsychopharmacology 34:952-63. 2009
    ..administration (acute and chronic) of the antidepressants citalopram and desmethylimipramine (DMI) influences somatostatin (somatotropin release inhibitory factor, SRIF) levels and SRIF receptor density (sst(1-5)) in rat brain...
  31. ncbi [Changes of encephalic contents of neuropeptides in rats with vascular dementia]
    De Qiang Li
    The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, China
    Zhejiang Da Xue Xue Bao Yi Xue Ban 37:468-71. 2008
    To investigate the changes of encephalic contents of somatostatin (SS) and arginine vasopressin (AVP) in rats with vascular dementia.
  32. doi Release of regulatory gut peptides somatostatin, neurotensin and vasoactive intestinal peptide by acid and hyperosmolal solutions in the intestine in conscious rats
    T Rudholm
    Department of Medicine, Karolinska Institutet, Karolinska University Hospital, Solna, Sweden
    Regul Pept 152:8-12. 2009
    ..of the intestinal mucosa to acid and hyperosmolal solutions on the release of the inhibitory gut peptides somatostatin (SOM), neurotensin (NT) and vasoactive intestinal peptide (VIP) was studied in conscious rats during ..
  33. doi SRIF receptor subtype expression and involvement in positive and negative contractile effects of somatostatin-14 (SRIF-14) in ventricular cardiomyocytes
    David Bell
    Division of Medicine and Therapeutics, School of Medicine, Dentistry and Biomedical Sciences, The Queen s University of Belfast
    Cell Physiol Biochem 22:653-64. 2008
    b>Somatostatin-14 (SRIF-14), a neuropeptide co-stored with acetylcholine in the cardiac parasympathetic innervation, exerts both positive and negative influences directly on contraction of ventricular cardiomyocytes, indicative of ..
  34. doi Diverging effects of cortistatin and somatostatin on the production and release of prostanoids from rat cortical microglia and astrocytes
    Cinzia Dello Russo
    Institute of Pharmacology, Catholic University Medical School, Largo Francesco Vito 1, 00168 Rome, Italy
    J Neuroimmunol 213:78-83. 2009
    Here we compared the effects of cortistatin and somatostatin on the production of prostanoids from primary cultures of rat cortical microglia and astrocytes...
  35. doi Tonic inhibition of somatostatin on C and Adelta afferent fibers in rat dorsal skin in vivo
    Jun Wang
    Department of Physiology and Pathophysiology, Xi an Jiaotong University School of Medicine, Xi an, Shaanxi 710061, PR China
    Brain Res 1288:50-9. 2009
    The purpose of this study was to investigate the effect of somatostatin (SST) in peripheral nerve terminals using local application of the SST receptor (SSTR) antagonist cyclo-somatostatin (c-SOM) injected into the receptive fields of ..
  36. doi Control of somatostatin (SS) secretion by CCK-1 and CCK-2 receptors' occupation in RIN-14B cells, a rat pancreatic islet cell line
    Karim El-Kouhen
    Faculty of Medicine, Department of Medicine, Universite de Sherbrooke, Sherbrooke, Quebec, Canada
    Pancreas 39:127-34. 2010
    This study evaluated the role played by cholecystokinin (CCK) receptors' occupation in the control of somatostatin (SS) secretion in RIN-14B cells.
  37. doi Colonic submucosal 5-HT(3) receptor-mediated somatostatin-dependent secretoinhibitory pathway is suppressed in water-immersion restraint stressed rats
    Yun Li
    Department of Physiology, School of Basic Medical Sciences, Capital Medical University, Beijing 100069, PR China
    Eur J Pharmacol 656:94-100. 2011
    ..receptor 3 in the submucosal plexus suppresses 5-HT-induced colonic ion secretion by increasing submucosal somatostatin release...
  38. ncbi Interrelationships between somatostatin sst2A receptors and somatostatin-containing axons in rat brain: evidence for regulation of cell surface receptors by endogenous somatostatin
    P Dournaud
    Department of Neurology and Neurosurgery, McGill University, Montreal, Quebec H3A 2B4, Canada
    J Neurosci 18:1056-71. 1998
    Using an antipeptide antibody, we reported previously on the distribution of the somatostatin sst2A receptor subtype in rat brain...
  39. ncbi Adrenomedullin stimulates somatostatin and thus inhibits histamine and acid secretion in the fundus of the stomach
    Ari B Hirsch
    Department of Medicine, Medical College of Virginia Virginia Commonwealth University, Richmond, VA, USA
    Regul Pept 110:189-95. 2003
    ..1 pM to 0.1 microM) caused a concentration-dependent increase in somatostatin secretion (EC(50), 1 x 10(-10)) that was accompanied by a reciprocal decrease in histamine secretion (EC(50), 1...
  40. ncbi Reciprocal paracrine pathways link atrial natriuretic peptide and somatostatin secretion in the antrum of the stomach
    W R Gower
    Department of Medicine, University of South Florida and James A Haley Veterans Hospital, Tampa, FL, USA
    Regul Pept 110:101-6. 2003
    ..superfused antral mucosal segments obtained from rat stomach to examine the paracrine pathways linking ANP and somatostatin secretion in this region.ANP (0.1 pM to 0...
  41. pmc Mechanisms for regulation of gastrin and somatostatin release from isolated rat stomach during gastric distention
    Yong Yu Li
    Department of Pathophysiology, Medical College of Tongji University, Shanghai 200331, China
    World J Gastroenterol 9:129-33. 2003
    ..To investigate the intragastric mechanisms for regulation of gastric neuroendocrine functions during gastric distention in isolated vascularly perfused rat stomach...
  42. ncbi Increase in somatostatin immunoreactivity in the suprachiasmatic nucleus of aged Wistar rats
    Barbara A M Biemans
    Animal Behaviour, University of Groningen, Kerklaan 30, 9751 NN, Haren, The Netherlands
    Brain Res 958:463-7. 2002
    ..We compared somatostatin (SS) and substance P (SP) immunoreactivity (ir) in aged (20-26 months) and young (6 months) Wistar rats...
  43. ncbi Effect of high temperature on gastrin, somatostatin and motilin production in ulcerous gastric antral mucosa of rats
    Feng Peng Sun
    Department of Gastroenterology, Nanfang Hospital, First Military Medical University, Guangzhou 510515, China
    Di Yi Jun Yi Da Xue Xue Bao 22:605-7. 2002
    To investigate the changes of gastrin, somatostatin and motilin production in the gastric antral mucosa of rats with experimental gastric ulcer.
  44. ncbi [Implication of the neuropeptides methionine enkephalin, neurotensin and somatostatin of the caudal trigeminal nucleus in the experimental migraine]
    M Samsam
    Laboratorio de Neuroanatomía de los Sistemas Peptidérgicos, Instituto de Neurociencias de Castilla y Leon INCYL, Facultad de Medicina, Salamanca, Espana
    Rev Neurol 34:724-9. 2002
    ..Moreover, the electrical stimulation of the trigeminal ganglion has been used as an experimental model in order to study the vascular headache, including the migraine...
  45. ncbi Glucagon-like peptide-1 analogue LY315902: effect on intestinal motility and release of insulin and somatostatin
    Erik Naslund
    Division of Surgery, Karolinska Institutet Danderyd Hospital, SE 182 88 Danderyd, Stockholm, Sweden
    Regul Pept 106:89-95. 2002
    ..The aim of the study is to assess the effect of LY315902 on fasting gastrointestinal motility, somatostatin and insulin release...
  46. ncbi Inhibitory effect of ghrelin on insulin and pancreatic somatostatin secretion
    E M Egido
    Clinica Puerta de Hierro y Departamento de Fisiologia, Universidad Autonoma de Madrid, Madrid, Spain
    Eur J Endocrinol 146:241-4. 2002
    ..The relationship between nutritional status and circulating ghrelin concentrations prompted us to investigate the effect of this peptide on pancreatic hormone secretion...
  47. ncbi Somatostatin-like immunoreactivity (SLIR) in rat harderian and meibomian glands and glands of Zeis
    Mortimer Lorber
    Department of Physiology and Biophysics, Georgetown University School of Medicine, Washington, DC, USA
    Adv Exp Med Biol 506:81-9. 2002
  48. ncbi Isolation, characterization, and DNA sequence of the rat somatostatin gene
    M A Tavianini
    J Biol Chem 259:11798-803. 1984
    The gene encoding rat somatostatin has been isolated from a lambda phage gene library. Phage harboring the gene were identified by plaque hybridization using a nick-translated fragment derived from the cDNA for rat somatostatin...
  49. pmc Primary structure of the gene encoding rat preprosomatostatin
    M R Montminy
    Proc Natl Acad Sci U S A 81:3337-40. 1984
    ..derived from a rat medullary thyroid carcinoma that encoded preprosomatostatin , a 116-amino-acid precursor of somatostatin. We now report the structural characterization of the rat somatostatin gene isolated from recombinant ..
  50. ncbi Nucleotide and amino acid sequence comparisons of preprosomatostatins
    P Argos
    J Biol Chem 258:8788-93. 1983
    ..Although there is a considerable number of amino acid substitutions within the aligned somatostatin-14 precursors, there is a high degree of structural relatedness among them...
  51. ncbi Rat pre-prosomatostatin. Structure and processing by microsomal membranes
    R H Goodman
    J Biol Chem 258:5570-3. 1983
    The tetradecapeptide hormone somatostatin arises from proteolytic processing of a large precursor, pre-prosomatostatin...
  52. ncbi Somatostatin-28 encoded in a cloned cDNA obtained from a rat medullary thyroid carcinoma
    R H Goodman
    J Biol Chem 257:1156-9. 1982
    ..a hybridization probe encoding an anglerfish islet pre-prosomatostatin, a precursor of the tetradecapeptide somatostatin, we have identified and isolated a clone containing a 400-base pair complementary DNA encoding most of the rat ..
  53. ncbi A new prosomatostatin-derived peptide reveals a pattern for prohormone cleavage at monobasic sites
    R Benoit
    Montreal General Hospital Research Institute, Department of Medicine, McGill University, Quebec, Canada
    Science 238:1126-9. 1987
    Cleavage of the peptide bonds of preprosomatostatin at basic residues near the carboxyl terminus yields somatostatin-14, somatostatin-28, and somatostatin-28 (1-12)...
  54. ncbi Biosynthesis of rat preprosomatostatin
    R H Goodman
    Adv Exp Med Biol 188:31-47. 1985
    The biologically active forms of somatostatin, somatostatin-14 (SS-14) and somatostatin-28 (SS-28) arise by post-translational cleavage of prosomatostatin. Prosomatostatin in turn is derived from a larger precursor, preprosomatostatin...
  55. ncbi Changes in thymus size, cellularity and relation between thymocyte subpopulations in young adult rats induced by somatostatin-14
    Danica M Petrović-Dergović
    Immunology Research Center Branislav Jankovic, Institute of Immunology and Virology Torlak, Belgrade, Serbia
    Neuropeptides 41:485-93. 2007
    The role of somatostatin on inhibition of both normal and tumor cell cycle, secretion of endocrine and exocrine cells, as well as induction apoptosis is well documented...
  56. ncbi Somatostatin suppresses ghrelin secretion from the rat stomach
    Mitsushi Shimada
    Department of Internal Medicine, Oita Medical University, Oita 879 5593, Japan
    Biochem Biophys Res Commun 302:520-5. 2003
    ..b>Somatostatin, a peptide produced in the gastric oxyntic mucosa, is known to suppress secretion of several gastrointestinal ..
  57. ncbi Food deprivation enhances somatostatin and somatostatin receptor subtype expression in rat colon
    Tamako Kido
    Programs for Biomedical Research, Division of Frontier Medical Science, Department of Medicine and Molecular Science, Graduate School of Biomedical Sciences, Hiroshima University, 1 2 3 Kasumi, Minami Ku, Hiroshima 734 8551, Japan
    Regul Pept 114:167-73. 2003
    b>Somatostatin, a peptide distributed widely throughout the gut, inhibits a variety of gastrointestinal functions. We previously reported that fasting for 48 h increased gastric somatostatin peptide and mRNA content...
  58. ncbi The effects of GH-releasing hormone/somatostatin on the 5'-promoter activity of the GH gene in vitro
    M Morishita
    Department of Medicine, Nagoya University Graduate School of Medicine and Hospital, Nagoya 466 8550, Japan
    J Mol Endocrinol 31:441-8. 2003
    The two hypothalamic hormones, GH-releasing hormone (GHRH) and somatostatin (SRIF), are known to regulate GH secretion...
  59. ncbi Regulation of rat pancreatic CCKB receptor and somatostatin expression by insulin
    Sophie Julien
    Department of Medicine, Faculty of Medicine, Universite de Sherbrooke, Sherbrooke, Quebec, Canada
    Diabetes 53:1526-34. 2004
    The cholecystokinin B receptor (CCK(B)R) is localized on pancreatic endocrine somatostatin delta-cells. Pancreatic somatostatin content was increased in diabetic rats...
  60. ncbi A novel variant of ionotropic glutamate receptor regulates somatostatin secretion from delta-cells of islets of Langerhans
    Akiko Muroyama
    Department of Biochemistry, Faculty of Pharmaceutical Sciences, Okayama University, Okayama 700 8530, Japan
    Diabetes 53:1743-53. 2004
    ..b>Somatostatin from delta-cells, considered a local inhibitor of islet function, reduces insulin and glucagon secretion by ..
  61. ncbi Somatostatin and the somatostatin receptor 2 are reciprocally controlled by calcineurin during cerebellar granule cell maturation
    Dana Kramer
    Department of Pharmacology, Cambridge University, UK
    J Neurochem 94:1374-83. 2005
    ..In this study, we investigated whether an important mediator of neuronal migration, somatostatin (Srif), alongside its receptors, is controlled in this manner in cerebellar granule cells...
  62. ncbi Cocaine- and amphetamine-related transcript peptide and somatostatin in rat intracardiac ganglia
    Robert J Richardson
    Department of Anatomy and Cell Biology, University of Melbourne, Parkville, Victoria, Australia
    Cell Tissue Res 324:17-24. 2006
    The distribution of somatostatin and cocaine and amphetamine-regulated transcript (CART) was investigated in rat intracardiac ganglia...
  63. ncbi Postsynaptic targets of somatostatin-containing interneurons in the rat basolateral amygdala
    Jay F Muller
    Department of Pharmacology, Physiology and Neuroscience, University of South Carolina School of Medicine, Columbia, South Carolina 29208, USA
    J Comp Neurol 500:513-29. 2007
    ..interneurons, very little is known about the synaptic outputs of the interneuronal subpopulation that expresses somatostatin (SOM)...
  64. ncbi Immunoreactivity for the GABAA receptor alpha1 subunit, somatostatin and Connexin36 distinguishes axoaxonic, basket, and bistratified interneurons of the rat hippocampus
    Agnes Baude
    MRC Anatomical Neuropharmacology Unit, Department of Pharmacology, Oxford University, Oxford OX1 3TH, UK
    Cereb Cortex 17:2094-107. 2007
    ..experiments were consistent with the finding that only bistratified cells express the neuropeptide somatostatin. From the molecular profiles, we estimate that basket, bistratified, and axoaxonic cells represent about 60%, ..
  65. ncbi Transient transcription of the somatostatin gene at the time of estrogen-dependent organization of the sexually dimorphic nucleus of the rat preoptic area
    Chitose Orikasa
    Department of Physiology, Nippon Medical School, Sendagi 1, Bunkyo, Tokyo 113 8602, Japan
    Endocrinology 148:1144-9. 2007
    In situ hybridization detected a transient, sex-specific transcription of somatostatin gene in the central part of the rat medial preoptic nucleus, which coincides with the sexually dimorphic nucleus of the preoptic area (SDN-POA), during,..
  66. ncbi Hemorrhage results in hepatic insulin-sensitizing substance-dependent insulin resistance mediated by somatostatin in rats
    Larissa I Seredycz
    Department of Pharmacology and Therapeutics, Faculty of Medicine, University of Manitoba, Winnipeg, Canada
    Neuroendocrinology 84:94-102. 2006
    ..Blockade of HISS action secondary to blood loss leads to a state known as HISS-dependent insulin resistance (HDIR) which results in a decrease in the glucose disposal action of insulin by 33 +/- 3%...
  67. ncbi RT-PCR and immunocytochemistry studies support the presence of somatostatin, cortistatin and somatostatin receptor subtypes in rat Kupffer cells
    C Xidakis
    Laboratory of Pharmacology, Department Basic Sciences, University of Crete, Faculty of Medicine, Heraklion, Crete, Greece
    Regul Pept 143:76-82. 2007
    The present study investigated the presence of somatostatin receptor subtypes (ssts) and the endogenous peptides somatostatin and cortistatin in rat Kupffer cells, since modulation of these cells by somatostatin may be important for the ..
  68. ncbi Colocalization of somatostatin receptor subtypes (SSTR1-5) with somatostatin, NADPH-diaphorase (NADPH-d), and tyrosine hydroxylase in the rat hypothalamus
    Ujendra Kumar
    Faculty of Pharmaceutical Sciences, Division of Pharmacology and Toxicology, University of British Columbia, Vancouver, Canada
    J Comp Neurol 504:185-205. 2007
    The hypothalamus is a major site of somatostatin (SST) production and action. SST is synthesized in several hypothalamic nuclei and involved in a variety of functions...
  69. ncbi Pulses of somatostatin release are slightly delayed compared with insulin and antisynchronous to glucagon
    Albert Salehi
    Department of Clinical Science, CRC UMAS, University of Lund, SE 20502 Malmo, Sweden
    Regul Pept 144:43-9. 2007
    It was early proposed that somatostatin-producing delta-cells in pancreatic islets have local inhibitory effects on the release of insulin and glucagon...
  70. ncbi Z-DNA in the rat somatostatin gene
    T E Hayes
    J Biol Chem 260:8145-56. 1985
    Two alternating purine-pyrimidine tracts flank the rat gene encoding the polypeptide hormone somatostatin. One lies 5' and one 3' to the gene; both consist of tandem repeats of the dinucleotide TG, with 25 repeats in the tract 5' and 15 ..