Src

Summary

Gene Symbol: Src
Description: SRC proto-oncogene, non-receptor tyrosine kinase
Alias: proto-oncogene tyrosine-protein kinase Src, Rous sarcoma oncogene, c-Src, p60-Src, pp60c-src, proto-oncogene c-Src, tyrosine protein kinase c-src, tyrosine protein kinase pp60-c-src, v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog, v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog
Species: rat

Top Publications

  1. ncbi Modulation of ERK 1/2 and p38 MAPK signaling pathways by ATP in osteoblasts: involvement of mechanical stress-activated calcium influx, PKC and Src activation
    S Katz
    Departamento de Biologia, Bioquimica y Farmacia, Universidad Nacional del Sur, San Juan 670, B8000ICN Bahia Blanca, Argentina
    Int J Biochem Cell Biol 38:2082-91. 2006
  2. doi Involvement of c-Src tyrosine kinase in SHP-1 phosphatase activation by Ang II AT2 receptors in rat fetal tissues
    Sergio E Alvarez
    Facultad de Quimica, Instituto Multidisciplinario de Investigaciones Biológicas IMIBIO CONICET, Bioquimica y Farmacia, Universidad Nacional de San Luis, San Luis, Argentina
    J Cell Biochem 105:703-11. 2008
  3. pmc Src-dependent STAT-3-mediated expression of monocyte chemoattractant protein-1 is required for 15(S)-hydroxyeicosatetraenoic acid-induced vascular smooth muscle cell migration
    Harihara S K Potula
    Department of Physiology, The University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA
    J Biol Chem 284:31142-55. 2009
  4. ncbi An intracellular multi-effector complex mediates somatostatin receptor 1 activation of phospho-tyrosine phosphatase eta
    Sara Arena
    Section of Pharmacology, Department of Oncology, Biology and Genetics, Univertsity of Genova 16132 Genova, Italy
    Mol Endocrinol 21:229-46. 2007
  5. doi EV71 induces COX-2 expression via c-Src/PDGFR/PI3K/Akt/p42/p44 MAPK/AP-1 and NF-kappaB in rat brain astrocytes
    Wei Hsuan Tung
    Department of Physiology and Pharmacology, Chang Gung University, Kwei San, Tao Yuan, Taiwan
    J Cell Physiol 224:376-86. 2010
  6. ncbi Integrin-mediated tyrosine phosphorylation of SHPS-1 and its association with SHP-2. Roles of Fak and Src family kinases
    M Tsuda
    Second Department of Internal Medicine, Kobe University School of Medicine, 7 5 1 Kusunoki cho, Chuo Ku, Kobe 650, Japan
    J Biol Chem 273:13223-9. 1998
  7. ncbi Caveolin-1 facilitates mechanosensitive protein kinase B (Akt) signaling in vitro and in vivo
    Daniel G Sedding
    Department of Internal Medicine I Cardiology, Giessen University, Giessen, Germany
    Circ Res 96:635-42. 2005
  8. doi Angiotensin II-induced osteopontin expression in vascular smooth muscle cells involves Gq/11, Ras, ERK, Src and Ets-1
    Keiko Abe
    Department of Medicine and Molecular Science, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima, Japan
    Hypertens Res 31:987-98. 2008
  9. doi Expression and signaling of G protein-coupled estrogen receptor 1 (GPER) in rat sertoli cells
    Thaís F G Lucas
    Section of Experimental Endocrinology, Department of Pharmacology, Universidade Federal de Sao Paulo, Escola Paulista de Medicina, INFAR, Vila Clementino, Sao Paulo, Brazil
    Biol Reprod 83:307-17. 2010
  10. doi Cell adhesion-dependent cofilin serine 3 phosphorylation by the integrin-linked kinase.c-Src complex
    Yong Bae Kim
    Department of Tumor Biology, Cancer Research Institute, Cell Dynamics Research Center, College of Medicine, Seoul National University, Seoul 110 799, Korea
    J Biol Chem 283:10089-96. 2008

Research Grants

  1. PI/PLC FUNCTION IN PREGNANT RAT MYOMETRIUM
    Mark Phillippe; Fiscal Year: 2002
  2. PHOSPHORYLATION IN RENAL CELL INJURY
    Goutam Ghosh Choudhury; Fiscal Year: 2004
  3. Chemokines, nitric oxide, and myocardial depression
    Bysani Chandrasekar; Fiscal Year: 2005
  4. Thrombin-Stimulated Intrauterine Signaling Pathway
    Mark Phillippe; Fiscal Year: 2007

Scientific Experts

Detail Information

Publications128 found, 100 shown here

  1. ncbi Modulation of ERK 1/2 and p38 MAPK signaling pathways by ATP in osteoblasts: involvement of mechanical stress-activated calcium influx, PKC and Src activation
    S Katz
    Departamento de Biologia, Bioquimica y Farmacia, Universidad Nacional del Sur, San Juan 670, B8000ICN Bahia Blanca, Argentina
    Int J Biochem Cell Biol 38:2082-91. 2006
    ..318220 (1 microM), a protein kinase C (PKC) inhibitor, and PP1 (50 microM), a potent and selective inhibitor of the Src-family tyrosine kinases. Ca(2+)-free extracellular medium (containing 0...
  2. doi Involvement of c-Src tyrosine kinase in SHP-1 phosphatase activation by Ang II AT2 receptors in rat fetal tissues
    Sergio E Alvarez
    Facultad de Quimica, Instituto Multidisciplinario de Investigaciones Biológicas IMIBIO CONICET, Bioquimica y Farmacia, Universidad Nacional de San Luis, San Luis, Argentina
    J Cell Biochem 105:703-11. 2008
    ..Interestingly, following receptor stimulation (1 min) c-Src was associated to AT(2) or SHP-1 immunocomplexes...
  3. pmc Src-dependent STAT-3-mediated expression of monocyte chemoattractant protein-1 is required for 15(S)-hydroxyeicosatetraenoic acid-induced vascular smooth muscle cell migration
    Harihara S K Potula
    Department of Physiology, The University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA
    J Biol Chem 284:31142-55. 2009
    ..In addition, 15(S)-HETE-induced VSMC migration was dependent on Src-mediated activation of signal transducer and activator of transcription-3 (STAT-3)...
  4. ncbi An intracellular multi-effector complex mediates somatostatin receptor 1 activation of phospho-tyrosine phosphatase eta
    Sara Arena
    Section of Pharmacology, Department of Oncology, Biology and Genetics, Univertsity of Genova 16132 Genova, Italy
    Mol Endocrinol 21:229-46. 2007
    ..and that involves, in a multimeric complex and sequential activation, the tyrosine kinases Janus kinase (JAK) 2 and Src, and the cytosolic phosphotyrosine phosphatase SHP-2...
  5. doi EV71 induces COX-2 expression via c-Src/PDGFR/PI3K/Akt/p42/p44 MAPK/AP-1 and NF-kappaB in rat brain astrocytes
    Wei Hsuan Tung
    Department of Physiology and Pharmacology, Chang Gung University, Kwei San, Tao Yuan, Taiwan
    J Cell Physiol 224:376-86. 2010
    ..that EV71-induced COX-2 expression and PGE(2) production were attenuated by pretreatment with the inhibitors of c-Src (PP1), PDGFR (AG1296), PI3K (Wortmannin), MEK1/2 (PD98059), NF-kappaB (helenalin), and AP-1 (Tanshinone) and ..
  6. ncbi Integrin-mediated tyrosine phosphorylation of SHPS-1 and its association with SHP-2. Roles of Fak and Src family kinases
    M Tsuda
    Second Department of Internal Medicine, Kobe University School of Medicine, 7 5 1 Kusunoki cho, Chuo Ku, Kobe 650, Japan
    J Biol Chem 273:13223-9. 1998
    SHPS-1 is a receptor-like glycoprotein that undergoes tyrosine phosphorylation and binds SHP-2, an Src homology 2 domain containing protein tyrosine phosphatase, in response to various mitogens...
  7. ncbi Caveolin-1 facilitates mechanosensitive protein kinase B (Akt) signaling in vitro and in vivo
    Daniel G Sedding
    Department of Internal Medicine I Cardiology, Giessen University, Giessen, Germany
    Circ Res 96:635-42. 2005
    ..When VSMC were subjected to cyclic stretch (0.5 Hz at 125% resting length), PI3-K, Akt, and Src kinases were found activated...
  8. doi Angiotensin II-induced osteopontin expression in vascular smooth muscle cells involves Gq/11, Ras, ERK, Src and Ets-1
    Keiko Abe
    Department of Medicine and Molecular Science, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima, Japan
    Hypertens Res 31:987-98. 2008
    ..DN-Src and DN-Fyn suppressed Ang II-induced OPN promoter activity...
  9. doi Expression and signaling of G protein-coupled estrogen receptor 1 (GPER) in rat sertoli cells
    Thaís F G Lucas
    Section of Experimental Endocrinology, Department of Pharmacology, Universidade Federal de Sao Paulo, Escola Paulista de Medicina, INFAR, Vila Clementino, Sao Paulo, Brazil
    Biol Reprod 83:307-17. 2010
    ..MAPK3/1 phosphorylation induced by ICI or G-1 was blocked by pertussis toxin, selective inhibitor of the SRC family of protein tyrosine kinases, metalloprotease inhibitor, MAP2K1/2 inhibitor, and epidermal growth factor ..
  10. doi Cell adhesion-dependent cofilin serine 3 phosphorylation by the integrin-linked kinase.c-Src complex
    Yong Bae Kim
    Department of Tumor Biology, Cancer Research Institute, Cell Dynamics Research Center, College of Medicine, Seoul National University, Seoul 110 799, Korea
    J Biol Chem 283:10089-96. 2008
    ..with suspended cells, fibronectin-adherent cells showed enhanced pS(3)cofilin, depending on ILK expression and c-Src activity...
  11. ncbi NMDA receptor activation results in tyrosine phosphorylation of NMDA receptor subunit 2A(NR2A) and interaction of Pyk2 and Src with NR2A after transient cerebral ischemia and reperfusion
    Y Liu
    Research Center for Biochemistry and Molecular Biology, Xuzhou Medical College, 84 West Huai hai Road, Xuzhou, 221002, Jiangsu, China
    Brain Res 909:51-8. 2001
    ..I/R) on tyrosine phosphorylation of NMDA receptor subunit 2A (NR2A) and the interaction of two tyrosine kinases, Src and Pyk2, with NR2A was investigated...
  12. ncbi Characterization and location of Src-dependent tyrosine phosphorylation in rat brain mitochondria
    Mauro Salvi
    Dipartimento di Chimica Biologica, Universita di Padova, Centro delle Biomembrane del CNR, Viale G Colombo 3, 35121 Padua, Italy
    Biochim Biophys Acta 1589:181-95. 2002
    ..Tyrosine phosphorylation disappears when mitochondria are treated with PP2, an inhibitor of the Src kinase family, suggesting the presence of members of this family in rat brain mitochondria...
  13. ncbi MEK mediates v-Src-induced disruption of the actin cytoskeleton via inactivation of the Rho-ROCK-LIM kinase pathway
    Geraldine Pawlak
    Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA
    J Biol Chem 277:26927-33. 2002
    Cellular transformation by v-Src is believed to be caused by aberrant activation of signaling pathways that are normally regulated by cellular Src...
  14. ncbi Role of c-SRC and ERK in acid-induced activation of NHE3
    Hirohiko Tsuganezawa
    Department of Internal Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9003, USA
    Kidney Int 62:41-50. 2002
    ..Incubation of cultured renal epithelial cells in acid media activates c-Src.
  15. pmc Activation of Src kinase in platelet-derived growth factor-B-dependent tubular regeneration after acute ischemic renal injury
    Mikiko Takikita-Suzuki
    Department of Medicine, Shiga University of Medical Science, Seta, Otsu, Japan
    Am J Pathol 163:277-86. 2003
    ..In the present study, we examined the activation of Src tyrosine kinase, a crucially important signaling molecule for PDGFR, and assessed the role of Src in PDGF-B-..
  16. ncbi Role of Src-induced dynamin-2 phosphorylation in caveolae-mediated endocytosis in endothelial cells
    Ayesha N Shajahan
    Department of Pharmacology, University of Illinois, College of Medicine, M C 868, 835 S Wolcott Avenue, Chicago, IL 60612, USA
    J Biol Chem 279:20392-400. 2004
    ..We addressed the role of Src phosphorylation of the GTPase dynamin-2 in the mechanism of caveolae release and albumin transport...
  17. ncbi Cardiomyocyte apoptosis triggered by RAFTK/pyk2 via Src kinase is antagonized by paxillin
    Jaime Melendez
    The Children s Hospital Research Foundation, Division of Molecular Cardiovascular Biology, Cincinnati, OH 45229, USA
    J Biol Chem 279:53516-23. 2004
    ..expression of RAFTK in neonatal rat cardiomyocytes involves concurrent increases in phosphorylation of Src, c-Jun N-terminal kinase, and p38 leading to characteristic apoptotic changes including cleavage of poly(ADP-ribose)..
  18. ncbi Aldosterone activates vascular p38MAP kinase and NADPH oxidase via c-Src
    Glaucia E Callera
    CIHR Multidisciplinary Research Group on Hypertension, Clinical Research Institute of Montreal, University of Montreal, Canada
    Hypertension 45:773-9. 2005
    ..that aldosterone induces activation of vascular mitogen-activated protein (MAP) kinases and NADPH oxidase via c-Src-dependent mechanisms in vascular smooth muscle cells (VSMCs)...
  19. ncbi c-Src-dependent nongenomic signaling responses to aldosterone are increased in vascular myocytes from spontaneously hypertensive rats
    Glaucia E Callera
    Ottawa Health Research Institute, University of Ottawa, Ottawa, Canada
    Hypertension 46:1032-8. 2005
    ..previously demonstrated that nongenomic signaling by aldosterone in vascular smooth muscle cells occurs through c-Src-dependent pathways...
  20. ncbi Interaction between src family kinases and rho-kinase in agonist-induced Ca2+-sensitization of rat pulmonary artery
    Greg A Knock
    Department of Asthma, Allergy and Respiratory Science, School of Medicine, King s College London, Room 3 20, Franklin Wilkins Building, Stamford Street, London SE1 9NH, UK
    Cardiovasc Res 77:570-9. 2008
    We investigated the role of src family kinases (srcFK) in agonist-mediated Ca2+-sensitization in pulmonary artery and whether this involves interaction with the rho/rho-kinase pathway.
  21. pmc Localization of PTP-1B, SHP-2, and Src exclusively in rat brain mitochondria and functional consequences
    Amal Arachiche
    INSERM U688 Physiopathologie Mitochondriale, University Victor Segalen Bordeaux 2, Bordeaux Cedex, France
    J Biol Chem 283:24406-11. 2008
    An immunodetection study of protein tyrosine phosphatase 1B (PTP-1B), SHP-2, and Src in isolated mitochondria from different rat tissues (brain, muscle, heart, liver, and kidney) revealed their exclusive localization in the brain...
  22. pmc Homophilic adhesion and CEACAM1-S regulate dimerization of CEACAM1-L and recruitment of SHP-2 and c-Src
    Mario M Müller
    Department of Cell and Molecular Biology, Karolinska Institutet, 171 77 Stockholm, Sweden
    J Cell Biol 187:569-81. 2009
    ..Although there is evidence that CEACAM1 binds and activates SHP-1, SHP-2, and c-Src, knowledge about the mechanism of transmembrane signaling is lacking...
  23. doi Proteomics study of oxidative stress and Src kinase inhibition in H9C2 cardiomyocytes: a cell model of heart ischemia-reperfusion injury and treatment
    Hsiu Chuan Chou
    Tissue Regeneration Bio Device Tech Lab, Medical Electronics and Device Technology Center, Industrial Technology Research Institute, Hsinchu 31040, Taiwan
    Free Radic Biol Med 49:96-108. 2010
    ..Importantly, Src kinase was shown to be a major upstream regulator of these events...
  24. doi Functional impact of PTP1B-mediated Src regulation on oxidative phosphorylation in rat brain mitochondria
    Etienne Hébert Chatelain
    Physiopathologie Mitochondriale, INSERM U688, Universite Victor Segalen Bordeaux 2, 146 rue Leo Saignat, 33076, Bordeaux Cedex, France
    Cell Mol Life Sci 68:2603-13. 2011
    Given the presence of Src and PTP1B within rat brain mitochondria, we have investigated whether PTP1B regulates Src activity in mitochondria as in the cytosol...
  25. ncbi Activating the PARP-1 sensor component of the groucho/ TLE1 corepressor complex mediates a CaMKinase IIdelta-dependent neurogenic gene activation pathway
    Bong Gun Ju
    Howard Hughes Medical Institute, University of California, San Diego, Department and School of Medicine, La Jolla, CA 92093, USA
    Cell 119:815-29. 2004
    ..The identification of PARP-1 as a regulated promoter-specific exchange factor required for activation of specific neurogenic gene programs is likely to be prototypic of similar molecular mechanisms...
  26. ncbi The pro-atherogenic cytokine interleukin-18 induces CXCL16 expression in rat aortic smooth muscle cells via MyD88, interleukin-1 receptor-associated kinase, tumor necrosis factor receptor-associated factor 6, c-Src, phosphatidylinositol 3-kinase, Akt, c-J
    Bysani Chandrasekar
    Department of Medicine, Medicine Cardiology, The University of Texas Health Science Center, San Antonio, Texas 78229 3900, USA
    J Biol Chem 280:26263-77. 2005
    ..b>Src kinase inhibitors PP1 and PP2, phosphatidylinositol 3-kinase (PI3K) inhibitors wortmannin and LY294002, Akt ..
  27. ncbi EGF receptor-mediated, c-Src-dependent, activation of Stat5b is downregulated in mitogenically responsive hepatocytes
    Tormod K Guren
    Department of Pharmacology, Faculty of Medicine, University of Oslo, Oslo, Norway
    J Cell Physiol 196:113-23. 2003
    ..The Src tyrosine kinase inhibitor CGP77675 blocked the EGF-induced activation of Stat5b, but did not affect the Stat5b ..
  28. ncbi Dual phosphorylations underlie modulation of unitary KCNQ K(+) channels by Src tyrosine kinase
    Yang Li
    Department of Physiology, University of Texas Health Science Center, San Antonio, Texas 78229, USA
    J Biol Chem 279:45399-407. 2004
    b>Src tyrosine kinase suppresses KCNQ (M-type) K(+) channels in a subunit-specific manner representing a mode of modulation distinct from that involving G protein-coupled receptors...
  29. ncbi Protein kinases and adherens junction dynamics in the seminiferous epithelium of the rat testis
    Nikki P Y Lee
    Population Council, 1230 York Avenue, New York, New York 10021, USA
    J Cell Physiol 202:344-60. 2005
    ..system utilizing Sertoli and germ cells was used to study the regulation of several protein kinases, including c-Src (the cellular form of the v-src transforming gene of Rous Sarcoma virus, RSV), carboxyl-terminal Src kinase (Csk), ..
  30. ncbi Store-operated Ca(2+) entry and tyrosine kinase pp60(src) hyperactivity are modulated by hyperglycemia in platelets from patients with non insulin-dependent diabetes mellitus
    Fernando R Saavedra
    Department of Physiology, University of Extremadura, 10071 Caceres, Spain
    Arch Biochem Biophys 432:261-8. 2004
    ..Consistent with this, the activity of the tyrosine kinase pp60(src) is enhanced in platelets from diabetic patients...
  31. ncbi Src kinase activity is required for integrin alphaVbeta3-mediated activation of nuclear factor-kappaB
    Donald L Courter
    Department of Bioengineering, University of Washington, Seattle, Washington 98195, USA
    J Biol Chem 280:12145-51. 2005
    ..The Src family of tyrosine kinases represents important transducers during integrin signaling, and the C terminus of beta3 ..
  32. ncbi Implication of phospholipase D2 in oxidant-induced phosphoinositide 3-kinase signaling via Pyk2 activation in PC12 cells
    Yoshiko Banno
    Department of Cell Signaling, Gifu University Graduate School of Medicine, Gifu 501 1194, Japan
    J Biol Chem 280:16319-24. 2005
    ..Furthermore, we found that PLD2 was associated with Pyk2 and Src, and that activation of PLD2 was required for H(2)O(2)-enhanced association of Src with Pyk2 leading to full ..
  33. ncbi Molecular basis for regulation of Src by the docking protein p130Cas
    Fariborz Nasertorabi
    Cancer Center, The Burnham Institute for Medical Research, La Jolla, California 92037, USA
    J Mol Recognit 19:30-8. 2006
    ..b>Src-family kinases (SFKs) bind a specific site in the carboxyl-terminal region of Cas and subsequently SFKs ..
  34. ncbi 17beta-estradiol induces the translocation of the estrogen receptors ESR1 and ESR2 to the cell membrane, MAPK3/1 phosphorylation and proliferation of cultured immature rat Sertoli cells
    Thaís F G Lucas
    Section of Experimental Endocrinology, Department of Pharmacology, Universidade Federal de Sao Paulo, Escola Paulista de Medicina, Sao Paulo, Brazil
    Biol Reprod 78:101-14. 2008
    ..Both effects reached a maximum after 10 min and were blocked by PP2, an inhibitor of the SRC family of protein tyrosine kinases, and by the antiestrogen ICI 182,780 (ICI)...
  35. doi The Met tyrosine kinase receptor in development and cancer
    Alessandra Gentile
    Division of Molecular Oncology, University of Turin Medical School, 10060, Candiolo Torino, Italy
    Cancer Metastasis Rev 27:85-94. 2008
    ..Several approaches have been recently developed to interfere with the tumorigenic and metastatic processes triggered by Met...
  36. doi Expression of tetraspan protein CD63 activates protein-tyrosine kinase (PTK) and enhances the PTK-induced inhibition of ROMK channels
    DaoHong Lin
    Department of Pharmacology, New York Medical College, Valhalla, New York 10595, USA
    J Biol Chem 283:7674-81. 2008
    ..Expression of CD63 in 293T cells stimulated the phosphorylation of tyrosine residue 416 of c-Src but decreased the phosphorylation of tyrosine residue 527, indicating that expression of CD63 stimulates the ..
  37. pmc Alpha-1 adrenergic receptor transactivates signal transducer and activator of transcription-3 (Stat3) through activation of Src and epidermal growth factor receptor (EGFR) in hepatocytes
    Chang Han
    Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    J Cell Physiol 216:486-97. 2008
    ..The observations that PE induced the formation of c-Src-Stat3 binding complex and phosphorylation of epidermal growth factor receptor (EGFR) and that inhibiting Src and ..
  38. pmc Nox4 NAD(P)H oxidase mediates Src-dependent tyrosine phosphorylation of PDK-1 in response to angiotensin II: role in mesangial cell hypertrophy and fibronectin expression
    Karen Block
    Department of Medicine, University of Texas Health Science Center, 7723 Floyd Curl Drive, San Antonio, TX 78229, USA
    J Biol Chem 283:24061-76. 2008
    ..total and on residues 9 and 373/376) are inhibited in cells transfected with small interfering RNA for Src, indicating that Src is upstream of PDK-1...
  39. pmc S100B Protein Regulates Astrocyte Shape and Migration via Interaction with Src Kinase: IMPLICATIONS FOR ASTROCYTE DEVELOPMENT, ACTIVATION, AND TUMOR GROWTH
    Flora Brozzi
    Department of Experimental Medicine and Biochemical Sciences, University of Perugia, C P 81 Succ 3, 06122 Perugia, Italy
    J Biol Chem 284:8797-811. 2009
    ..Finally, we show that S100B interacts with Src kinase, thereby stimulating the PI3K/Akt and PI3K/RhoA pathways...
  40. pmc Role of nonreceptor protein tyrosine kinases during phospholipase C-gamma 1-related uterine contractions in the rat
    Mark Phillippe
    Department of Obstetrics, Gynecology and Reproductive Sciences, University of Vermont College of Medicine, Burlington, Vermont 05405, USA
    Reprod Sci 16:265-73. 2009
    ..Western blots were performed utilizing antibodies to phosphotyrosine-phospholipase C1, total phospholipase C1, c-Src kinase and Lck kinase...
  41. doi Peroxynitrite induces tyrosine residue modifications in synaptophysin C-terminal domain, affecting its interaction with src
    Cinzia Mallozzi
    Department of Cell Biology and Neuroscience, Istituto Superiore di Sanita, Viale Regina Elena, Rome, Italy
    J Neurochem 111:859-69. 2009
    ..We found that tyrosine-phosphorylated, but not tyrosine-nitrated, SYP bound to the src tyrosine kinase and enhanced its catalytic activity...
  42. doi Neuroprotective profile of novel SRC kinase inhibitors in rodent models of cerebral ischemia
    Shi Liang
    Discovery Neuroscience, Wyeth Research, CN 8000, Princeton, NJ 08543, USA
    J Pharmacol Exp Ther 331:827-35. 2009
    b>Src kinase signaling has been implicated in multiple mechanisms of ischemic injury, including vascular endothelial growth factor (VEGF)-mediated vascular permeability that leads to vasogenic edema, a major clinical complication in stroke ..
  43. doi Vascular superoxide production by endothelin-1 requires Src non-receptor protein tyrosine kinase and MAPK activation
    Miguel Romero
    Department of Pharmacology, School of Pharmacy, University of Granada, 18071 Granada, Spain
    Atherosclerosis 212:78-85. 2010
    ET-1 induces vascular O(2)(*-) production via activation of NADPH oxidase. We have investigated whether c-Src and MAPKs activation are involved in ET-1-induced vascular oxidative response...
  44. pmc Dopamine D1 receptor-mediated NMDA receptor insertion depends on Fyn but not Src kinase pathway in prefrontal cortical neurons
    Jian Li Hu
    Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, PA 19129, USA
    Mol Brain 3:20. 2010
    ..The aim of the work reported here is to explore the signaling pathway underlying D1 receptor-mediated trafficking of NMDA receptors in cultured rat prefrontal cortical neurons...
  45. doi c-Src in paraventricular nucleus modulates sympathetic activity and cardiac sympathetic afferent reflex in renovascular hypertensive rats
    Ying Han
    Department of Physiology, Nanjing Medical University, Nanjing, China
    Pflugers Arch 461:437-46. 2011
    ..The study was to determine whether c-Src in paraventricular nucleus (PVN) is involved in the enhanced CSAR and sympathetic activation in hypertensive rats ..
  46. pmc 15-Lipoxygenase-1-enhanced Src-Janus kinase 2-signal transducer and activator of transcription 3 stimulation and monocyte chemoattractant protein-1 expression require redox-sensitive activation of epidermal growth factor receptor in vascular wall remodeli
    Nikhlesh K Singh
    Department of Physiology, The University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA
    J Biol Chem 286:22478-88. 2011
    ..Interference with EGFR activation blocked 15(S)-HETE-induced Src and STAT3 tyrosine phosphorylation, monocyte chemoattractant protein-1 (MCP-1) expression and VSMC migration...
  47. pmc Neuroimmune modulation following traumatic stress in rats: evidence for an immunoregulatory cascade mediated by c-Src, miRNA222 and PAK1
    Hui Zhao
    Department of Integrative Medicine and Neurobiology, State Key Lab of Medical Neurobiology, Shanghai Medical College, Brain Research Institute, Fudan University, Shanghai, P R China
    J Neuroinflammation 8:159. 2011
    Neuroimmune modulation following traumatic stress is accompanied by cortical upregulation of c-Src expression, but the mechanistic details of the potential regulatory link between c-Src expression and immunosuppression have not been ..
  48. doi AT₂receptors recruit c-Src, SHP-1 and FAK upon activation by Ang II in PND15 rat hindbrain
    Leonardo R Seguin
    Instituto Multidisciplinario de Investigaciones Biológicas IMIBIO SL CONICET, Facultad de Quimica, Bioquimica y Farmacia, Universidad Nacional de San Luis, San Luis, Argentina
    Neurochem Int 60:199-207. 2012
    ..The possible participation of c-Src in Ang II-mediated SHP-1 activation, we demonstrated by recruitment of c-Src in immunocomplexes obtained with anti ..
  49. pmc HIF-1 and c-Src mediate increased glucose uptake induced by endothelin-1 and connexin43 in astrocytes
    José Carlos Valle-Casuso
    Departamento de Bioquimica y Biologia Molecular, Instituto de Neurociencias de Castilla y Leon INCYL, Universidad de Salamanca, Salamanca, Spain
    PLoS ONE 7:e32448. 2012
    ..The activity of oncogenes such as c-Src can up-regulate HIF-1α...
  50. doi Anoxia-induced NMDA receptor activation opens pannexin channels via Src family kinases
    Nicholas L Weilinger
    Hotchkiss Brain Institute, Department of Cell Biology and Anatomy, University of Calgary, Calgary, Alberta, Canada T2N 4N1
    J Neurosci 32:12579-88. 2012
    ..Anoxia or exogenous NMDA activated Src family kinases (SFKs), as measured by increased phosphorylation of SFKs at Y416...
  51. doi Modulation of gastric mucosal inflammatory responses to Helicobacter pylori via ghrelin-induced protein kinase Cδ tyrosine phosphorylation
    B L Slomiany
    Research Center, C875, Rutgers School of Dental Medicine, Rutgers, The State University of New Jersey, 110 Bergen Street, PO Box 1709, Newark, NJ, 07103 2400, USA
    Inflammopharmacology 22:251-62. 2014
    ..responses to Helicobacter pylori by controlling the activation of constitutive nitric oxide synthase via Src/Akt-dependent phosphorylation that requires phosphatidylinositol 3-kinase (PI3K) participation...
  52. pmc Differential effects of c-Src and c-Yes on the endocytic vesicle-mediated trafficking events at the Sertoli cell blood-testis barrier: an in vitro study
    Xiang Xiao
    Mary M Wohlford Laboratory for Male Contraceptive Research, Center for Biomedical Research, Population Council, New York, New York
    Am J Physiol Endocrinol Metab 307:E553-62. 2014
    ..We hypothesized that c-Src and c-Yes might work in contrasting roles in endocytic vesicle-mediated trafficking, serving as molecular switches, ..
  53. pmc Caveolin-1 phosphorylation regulates vascular endothelial insulin uptake and is impaired by insulin resistance in rats
    Hong Wang
    Division of Endocrinology and Metabolism, Department of Internal Medicine, University of Virginia Health System, 450 Ray C Hunt Drive, Box 801410, Charlottesville, VA, 22908, USA
    Diabetologia 58:1344-53. 2015
    ..Here, we examined the role of insulin-stimulated tyrosine 14 (Tyr(14))-caveolin-1 phosphorylation in mediating EC insulin uptake and the role of cellular Src-kinase (cSrc), TNF-α/IL-6 and high fat diet (HFD) in regulating this process.
  54. pmc Src Tyrosine Kinase Activation by 4-Hydroxynonenal Upregulates p38, ERK/AP-1 Signaling and COX-2 Expression in YPEN-1 Cells
    Eun Ji Jang
    Molecular Inflammation Research Center for Aging Intervention MRCA, Department of Pharmacy, Pusan National University, Busan, Republic of Korea
    PLoS ONE 10:e0129244. 2015
    ..In the present study, we investigated the interaction between 4-HNE and Src (a non-receptor tyrosine kinase) for its involvement in the molecular modulation of the inflammatory signaling ..
  55. pmc Microtubule and Actin Interplay Drive Intracellular c-Src Trafficking
    Christopher Arnette
    Department of Cell and Developmental Biology, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America
    PLoS ONE 11:e0148996. 2016
    The proto-oncogene c-Src is involved in a variety of signaling processes. Therefore, c-Src spatiotemporal localization is critical for interaction with downstream targets...
  56. pmc Connexin43 recruits PTEN and Csk to inhibit c-Src activity in glioma cells and astrocytes
    Ana González-Sánchez
    Instituto de Neurociencias de Castilla y Leon INCYL, Departamento de Bioquimica y Biologia Molecular, Universidad de Salamanca, Salamanca, Spain
    Oncotarget 7:49819-49833. 2016
    ..ectopic expression exerts important effects, including the inhibition of the proto-oncogene tyrosine-protein kinase Src (c-Src). In this work we aimed to investigate the mechanism responsible for this effect...
  57. ncbi Interaction between chicken protein tyrosine phosphatase 1 (CPTP1)-like rat protein phosphatase 1 (PTP1) and p60(v-src) in v-src-transformed Rat-1 fibroblasts
    Eun Joo Jung
    Department of Biochemistry, College of Medicine, Gyeongsang National University, Chinju 660 751, Korea
    Exp Mol Med 34:476-80. 2002
    ..Using anti-CPTP1 antibody, we identified CPTP1-like rat PTP1 of 51 kDa in Rat-1 and v-src-transformed Rat-1 fibroblasts...
  58. ncbi Integrin activates receptor-like protein tyrosine phosphatase alpha, Src, and Rho to increase prolactin gene expression through a final phosphatidylinositol 3-kinase/cytoskeletal pathway that is additive with insulin
    Anthony I Vulin
    Department of Pharmacology, New York University Medical Center, New York, New York 10016, USA
    Endocrinology 146:3535-46. 2005
    ..Others suggested that RPTPalpha was a key intermediary between integrins and activation of Src. We present evidence that inhibition of insulin-increased prolactin gene transcription was secondary to RPTPalpha ..
  59. doi Involvement of c-Src/STAT3 signal in EGF-induced proliferation of rat spermatogonial stem cells
    Jia Xiang Chen
    Department of Physiology, Medical College of Nanchang University, Donghu District, Nanchang 330006, People s Republic of China
    Mol Cell Biochem 358:67-73. 2011
    ..proliferation in a dose-dependent manner and significantly increased the protein levels of phosphated c-Src (p-c-Src) and phosphated signal transducer and activator of transcription 3 (p-STAT3)...
  60. pmc Localization of caveolin-1 and c-src in mature and differentiating photoreceptors: raft proteins co-distribute with rhodopsin during development
    Agnes I Berta
    Department of Human Morphology and Developmental Biology, Semmelweis University Budapest, Tuzolto u 58, Budapest, Hungary
    J Mol Histol 42:523-33. 2011
    ..Therefore the purpose of our studies was to follow the localization pattern of caveolin-1, phospho-caveolin-1 and c-src in the developing retina and compare it to that observed in adults...
  61. pmc Calcium-permeable α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors trigger neuronal nitric-oxide synthase activation to promote nerve cell death in an Src kinase-dependent fashion
    Renato Socodato
    Program of Neurosciences and Department of Neurobiology, Institute of Biology, Fluminense Federal University, Niteroi, 24020 971, Brazil
    J Biol Chem 287:38680-94. 2012
    ..The Src-tyrosine kinase has been implicated in modulating neurotransmission in CNS...
  62. ncbi The GTPase dynamin binds to and is activated by a subset of SH3 domains
    I Gout
    Ludwig Institute for Cancer Research, London, England
    Cell 75:25-36. 1993
    b>Src homology 3 (SH3) domains have been implicated in mediating protein-protein interactions in receptor signaling processes; however, the precise role of this domain remains unclear...
  63. ncbi Mammalian NUMB is an evolutionarily conserved signaling adapter protein that specifies cell fate
    J M Verdi
    Amgen Institute, Ontario Cancer Institute, Department of Medical Biophysics, University of Toronto, Toronto M5G 2C1, Canada
    Curr Biol 6:1134-45. 1996
    ..Part of the Drosophila NUMB protein exhibits homology to the SHC phosphotyrosine-binding (PTB) domain, suggesting a potential link to tyrosine-kinase signal transduction...
  64. ncbi Activating SRC mutation in a subset of advanced human colon cancers
    R B Irby
    Department of Surgery, H Lee Moffitt Cancer Center and Research Institute, University of South Florida College of Medicine, Tampa 33612, USA
    Nat Genet 21:187-90. 1999
    The discovery of Rous sarcoma virus (RSV) led to the identification of cellular Src (c-Src), a non-receptor tyrosine kinase, which has since been implicated in the development of numerous human cancers...
  65. ncbi Increased expression of neuronal Src and tyrosine phosphorylation of NMDA receptors in rat brain after systemic treatment with MK-801
    A Linden
    A I Virtanen Institute, University of Kuopio, P O B 1627, 70211 Kuopio, Finland
    Neuropharmacology 40:469-81. 2001
    ..that systemic treatment with the uncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist MK-801 increases Src expression and NMDA receptor phosphorylation in rat brain...
  66. ncbi Regulation of an ERG K+ current by Src tyrosine kinase
    Francisco S Cayabyab
    Division of Cellular and Molecular Biology, Toronto Western Research Institute, University Health Network and Department of Physiology, University of Toronto, Toronto, Ontario M5T 2S8, Canada
    J Biol Chem 277:13673-81. 2002
    ..The whole cell ERG current was reduced by protein-tyrosine kinase inhibitors or the Src-selective inhibitory peptide, src40-58, but not by a scrambled peptide...
  67. ncbi Cloning of the proto-oncogene c-src from rat testis
    O Al-Khalili
    Department of Physiology, Center for Cell and Molecular Signaling, Emory University School of Medicine, Atlanta, GA, USA
    DNA Seq 12:425-9. 2001
    The cellular homolog of the oncogene v-src, the proto-oncogene c-src, was cloned from rat testis using a high stringency polymerase chain reaction...
  68. ncbi Ligand-independent trans-activation of the platelet-derived growth factor receptor by reactive oxygen species requires protein kinase C-delta and c-Src
    Shuichi Saito
    Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 0146, USA
    J Biol Chem 277:44695-700. 2002
    ..at Tyr(1021), a phospholipase C-gamma binding site, involving the requirement of protein kinase C-delta and c-Src that is distinct from a ligand-dependent autophosphorylation...
  69. ncbi Tyrosine kinase and tyrosine phosphatase participate in regulation of interactions of NMDA receptor subunit 2A with Src and Fyn mediated by PSD-95 after transient brain ischemia
    Min Chen
    Research Center for Biochemistry and Molecular Biology, Xuzhou Medical College, 84 West Huai hai Road, Xuzhou, 221002 P R, Jiangsu, China
    Neurosci Lett 339:29-32. 2003
    ..receptor subunit 2A (NR2A) and the interactions among NR2A, postsynaptic density protein 95 (PSD-95), Fyn/Src after brain ischemia/reperfusion (I/R)...
  70. ncbi Fer kinase/FerT and adherens junction dynamics in the testis: an in vitro and in vivo study
    Yong Mei Chen
    Population Council, New York, New York, 10021, USA
    Biol Reprod 69:656-72. 2003
    ..Studies by immunoprecipitation revealed that Fer kinase associated with N-cadherin, gamma-catenin, p120ctn, c-Src (a putative PTK and the product of the transforming, sarcoma-inducing gene of Rous sarcoma virus), Rab 8 (a GTPase),..
  71. ncbi Protein kinase C delta induces Src kinase activity via activation of the protein tyrosine phosphatase PTP alpha
    Dominique T Brandt
    Medizinische Hochschule Hannover, Department of Nephrology, 30625 Hannover, Germany
    J Biol Chem 278:34073-8. 2003
    ..reorganization of the actin cytoskeleton in smooth muscle cells is transmitted by the non-receptor tyrosine kinase, Src. Several authors have described how 12-O-tetradecanoylphorbol-13-acetate (TPA) stimulation of cells results in an ..
  72. ncbi Sensitization of epidermal growth factor-induced signaling by bradykinin is mediated by c-Src. Implications for a role of lipid microdomains
    Eun Mi Hur
    Department of Life Science, Division of Molecular and Life Sciences, Pohang University of Science and Technology, San 31, Hyoja Dong, Pohang 790 784, Republic of Korea
    J Biol Chem 279:5852-60. 2004
    ..Bradykinin caused activation of p60Src and Src-dependent phosphorylation of the EGFR on Tyr-845 in lipid rafts, as well as recruitment of phospholipase C (PLC) ..
  73. ncbi Tumor metastasis but not tumor growth is dependent on Src-mediated vascular permeability
    Michele L Criscuoli
    La Jolla Institute for Molecular Medicine, Division of Cancer Biology, San Diego, CA 92121, USA
    Blood 105:1508-14. 2005
    ..Previous studies have shown a requirement for Src kinase in VEGF-mediated VP and signaling in blood vessels...
  74. ncbi PKA phosphorylation of Src mediates Rap1 activation in NGF and cAMP signaling in PC12 cells
    Yutaro Obara
    The Vollum Institute, L474, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97239, USA
    J Cell Sci 117:6085-94. 2004
    Recent studies suggest that the tyrosine kinase Src plays an important role in the hormonal regulation of extracellular signal-regulated kinases (ERKs) via cyclic AMP (cAMP)...
  75. ncbi The rat tyrosine phosphatase eta increases cell adhesion by activating c-Src through dephosphorylation of its inhibitory phosphotyrosine residue
    Ilaria Le Pera
    Department of Experimental and Clinical Medicine, Medical School of Catanzaro, Magna Graecia University of Catanzaro, 88100 Catanzaro, Italy
    Oncogene 24:3187-95. 2005
    ..Here, we report that the r-PTPeta protein binds to c-Src in living cells and dephosphorylates the c-Src inhibitory tyrosine phosphorylation site (Tyr 529), thereby ..
  76. ncbi Prostaglandin E2 stimulates fibronectin expression through EP1 receptor, phospholipase C, protein kinase Calpha, and c-Src pathway in primary cultured rat osteoblasts
    Chih Hsin Tang
    Departments of Pharmacology and Orthopaedics, College of Medicine, National Taiwan University, Taipei, Taiwan
    J Biol Chem 280:22907-16. 2005
    ..acid tetrakis(acetoxymethyl ester)), phosphatidylinositol-phospholipase C inhibitor (U73122), or Src inhibitor (PP2) attenuated the PGE(2)-induced Fn expression...
  77. pmc Involvement of Src tyrosine kinase and mitogen-activated protein kinase in the facilitation of calcium channels in rat nucleus of the tractus solitarius by angiotensin II
    Takayuki Endoh
    Department of Physiology, Tokyo Dental College, 1 2 2 Masago, Mihama ku, Chiba 261 8502, Japan
    J Physiol 568:851-65. 2005
    ..Intracellular dialysis of the Galpha(i)-protein antibody attenuated the Ang II-induced facilitation of I(Ca). Both Src tyrosine kinase inhibitor and mitogen-activated protein kinase (MAPK) inhibitor attenuated the Ang II-induced ..
  78. ncbi Insulin-dependent phosphorylation of DPP IV in liver. Evidence for a role of compartmentalized c-Src
    Nicolas Bilodeau
    Pediatric Research Unit, CRCHUL CHUQ, Faculty of Medicine, Laval University, Quebec, Canada
    FEBS J 273:992-1003. 2006
    ..DPP IV coimmunoprecipitated with the cellular tyrosine kinase Src (c-Src) with maximal association also observed after 2 min following insulin injection...
  79. ncbi Integrin receptor activation triggers converging regulation of Cav1.2 calcium channels by c-Src and protein kinase A pathways
    Peichun Gui
    Department of Medical Pharmacology and Physiology, University of Missouri School of Medicine, Columbia, Missouri 65212, USA
    J Biol Chem 281:14015-25. 2006
    ..These sites are known to be phosphorylated by protein kinase A (PKA) and c-Src, respectively, and are conserved between rat neuronal (Cav1.2c) and smooth muscle (Cav1.2b) isoforms...
  80. ncbi Angiotensin II-dependent Src and Smad1 signaling pathway is crucial for the development of diabetic nephropathy
    Akira Mima
    Department of Nephrology, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Lab Invest 86:927-39. 2006
    ..staining and Western blotting showed that the increased expression of Smad1, phospho-Smad1, and phospho-Src was inhibited by olmesartan...
  81. pmc Activated c-SRC in ductal carcinoma in situ correlates with high tumour grade, high proliferation and HER2 positivity
    G R Wilson
    Department of Academic Surgery, Research and Education Building 2nd Floor, South Manchester University Hospital, Wythenshawe, Manchester, UK
    Br J Cancer 95:1410-4. 2006
    Overexpression and/or activity of c-Src non-receptor tyrosine kinase is associated with progression of several human epithelial cancers including breast cancer...
  82. ncbi Repetitive deformation activates focal adhesion kinase and ERK mitogenic signals in human Caco-2 intestinal epithelial cells through Src and Rac1
    Lakshmi S Chaturvedi
    Surgical Service, John D Dingell Veterans Affairs Medical Center, Wayne State University, Detroit, Michigan 48201, USA
    J Biol Chem 282:14-28. 2007
    ..However, the upstream mediators of these effects are unknown. We investigated whether Src and Rac1 mediate deformation-induced FAK and ERK phosphorylation and proliferation in human Caco-2 and rat IEC-6 ..
  83. ncbi Constitutive diffuse activation of phosphoinositide 3-kinase at the plasma membrane by v-Src suppresses the chemotactic response to PDGF by abrogating the polarity of PDGF receptor signalling
    Anna Platek
    Universite Catholique de Louvain, Christian de Duve Institute of Cellular Pathology, CELL Unit, UCL 75 41, Avenue Hippocrate, 75, B 1200 Brussels, Belgium
    Exp Cell Res 313:1090-105. 2007
    Cancer cells depend on chemotaxis for invasion and frequently overexpress and/or activate Src. We previously reported that v-Src accelerates motility by promoting phosphoinositide 3-kinase (PI3-K) signalling but abrogates chemotaxis...
  84. pmc Protein kinase Cepsilon (PKCepsilon) and Src control PKCdelta activation loop phosphorylation in cardiomyocytes
    Vitalyi O Rybin
    Department of Pharmacology, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    J Biol Chem 282:23631-8. 2007
    ..Further studies implicate Src in this mechanism, showing that 1) PKCepsilon overexpression increases PKCdelta-Thr(505) phosphorylation in ..
  85. ncbi Regulation of c-Src activity in glutamate-induced neurodegeneration
    Savita Khanna
    Laboratory of Molecular Medicine, Department of Surgery, Davis Heart and Lung Research Institute, The Ohio State University Medical Center, Columbus, Ohio 43210, USA
    J Biol Chem 282:23482-90. 2007
    c-Src is heavily expressed in the brain and in human neural tissues...
  86. ncbi Suppression of c-Src activity stimulates muscle differentiation via p38 MAPK activation
    Min Jin Lim
    Department of Biochemistry and Molecular Biology BK21 project, Medical Research Center for Bioreaction to Reactive Oxygen Species and Biomedical Science Institute, School of Medicine, Kyung Hee University, Seoul 130 701, Republic of Korea
    Arch Biochem Biophys 465:197-208. 2007
    Role of c-Src in muscle differentiation has been controversial. Here, we investigated if c-Src positively or negatively regulates muscle differentiation, using H9c2 and C2C12 cell lines...
  87. ncbi Platelet-derived growth factor-induced stabilization of cyclooxygenase 2 mRNA in rat smooth muscle cells requires the c-Src family of protein-tyrosine kinases
    Kaiming Xu
    Department of Pharmacology, Emory University, 1510 Clifton Road, Atlanta, GA 30322, USA
    J Biol Chem 282:32699-709. 2007
    ..Activation of PDGF receptor (PDGFR) in rat aortic vascular smooth muscle cells leads to c-Src-dependent stabilization of COX-2 mRNA requiring an AU-rich region within the 3'-untranslated region of this ..
  88. doi The role of reelin in adult synaptic function and the genetic and epigenetic regulation of the reelin gene
    Jonathan M Levenson
    Galenea, Corp, Cambridge, MA 02139, USA
    Biochim Biophys Acta 1779:422-31. 2008
    ....
  89. pmc Src-mediated cortactin phosphorylation regulates actin localization and injurious blebbing in acinar cells
    Vijay P Singh
    Department of Biochemistry and Molecular Biology and the Miles and Shirley Fiterman Center for Digestive Diseases, Mayo Clinic, Rochester, MN 55905, USA
    Mol Biol Cell 19:2339-47. 2008
    ..We observed that suprastimulation results in a rapid activation of Src and relocalization of the actin-binding protein cortactin from the apical to the basolateral domain at the necks of ..
  90. doi Tyrosine phosphorylation of HPK1 by activated Src promotes ischemic brain injury in rat hippocampal CA1 region
    Ting Li
    Research Center for Biochemistry and Molecular Biology, Jiangsu Key Laboratory of Brain Disease Bioinformation, Xuzhou Medical College, 84 West Huaihai Road, Xuzhou, Jiangsu 221002, China
    FEBS Lett 582:1894-900. 2008
    ..Immunoprecipitation and immunoblot results showed that PP2 and MK801 significantly decreased the activation of Src, HPK1, MLK3, JNK3 and c-Jun, respectively, during ischemia/reperfusion...
  91. doi The transactivated epidermal growth factor receptor recruits Pyk2 to regulate Src kinase activity
    Dag Schauwienold
    Abteilung Klinische Pharmakologie, Ruhr Universitat Bochum, 44780 Bochum, Germany
    J Biol Chem 283:27748-56. 2008
    ..epidermal growth factor (EGF) receptor ligands and activation of the nonreceptor tyrosine kinases Pyk2 and Src contributed to the thrombin-induced ERK1/2 phosphorylation...
  92. pmc Neuroprotection of GluR5-containing kainate receptor activation against ischemic brain injury through decreasing tyrosine phosphorylation of N-methyl-D-aspartate receptors mediated by Src kinase
    Jie Xu
    Research Center for Biochemistry and Molecular Biology, Jiangsu Key Laboratory of Brain Disease Bio information, Xuzhou Medical College, Xuzhou 221002, China
    J Biol Chem 283:29355-66. 2008
    ..propanoic acid (ATPA), a selective GluR5 agonist, could suppress Src tyrosine phosphorylation and interactions among N-methyl-D-aspartate (NMDA) receptor subunit 2A (NR2A), ..
  93. pmc Synergistic activation of glucose-6-phosphate dehydrogenase and NAD(P)H oxidase by Src kinase elevates superoxide in type 2 diabetic, Zucker fa/fa, rat liver
    Rakhee S Gupte
    Department of Biochemistry and Molecular Biology, University of South Alabama, Mobile, AL 36688, USA
    Free Radic Biol Med 47:219-28. 2009
    ..Inhibition of PI3 kinase and Src kinases decreased (p < 0...
  94. pmc Redox-sensitive Akt and Src regulate coronary collateral growth in metabolic syndrome
    Ryan Reed
    Department of Biochemistry, Louisiana State University Health Sciences Center, New Orleans, Louisiana, USA
    Am J Physiol Heart Circ Physiol 296:H1811-21. 2009
    ..Here, we determined whether the activation of Src, a possible upstream regulator, was altered in JCR rats and whether redox-dependent Src and Akt activation were ..
  95. doi SRC family kinase activity is up-regulated in hormone-refractory prostate cancer
    Oleg Tatarov
    Division of Cancer Sciences and Molecular Pathology, Faculty of Medicine, Glasgow Royal Infirmary, Glasgow, UK
    Clin Cancer Res 15:3540-9. 2009
    Although Src family kinase (SFK) inhibitors are now in clinical trials for the treatment of androgen-independent prostate cancer (AIPC), there are no studies relating SFK activation to patient survival...
  96. doi FGF-1-induced reactions for biogenesis of apoE-HDL are mediated by src in rat astrocytes
    Tomo Nishida
    Biochemistry, Nagoya City University Graduate School of Medical Sciences, Kawasumi 1, Mizuho cho, Mizuho ku, Nagoya 467 8601, Japan
    J Biochem 146:881-6. 2009
    ..FGF-1-induced phosphorylation of Src, and phosphorylation of MEK, ERK and Ark was inhibited by Src inhibitors in rat astrocytes...
  97. ncbi Elevated Src kinase activity attenuates Tamoxifen response in vitro and is associated with poor prognosis clinically
    Liam Morgan
    Department of Medical Biochemistry and Immunology, Cardiff University, Cardiff, UK
    Cancer Biol Ther 8:1550-8. 2009
    Activated Src kinase may contribute to the progression and spread of breast cancers and recent in vitro evidence suggests a role for Src in acquired endocrine resistance...
  98. doi The regulatory domain of protein kinase C delta positively regulates insulin receptor signaling
    Avraham I Jacob
    Mina and Everard Goodman Faculty of Life Sciences, Gonda Diagnostic Center, Bar Ilan University, Ramat Gan 52900, Israel
    J Mol Endocrinol 44:155-69. 2010
    ..Basal binding of Src to PKCdelta was higher in both PKCdelta/alpha- and PKCalpha/delta-expressing cells compared to control...
  99. doi Transduced PDZ1 domain of PSD-95 decreases Src phosphorylation and increases nNOS (Ser847) phosphorylation contributing to neuroprotection after cerebral ischemia
    Wei Wei Wang
    Research Center for Biochemistry and Molecular Biology, Xuzhou Medical College, Xuzhou, Jiangsu, China
    Brain Res 1328:162-70. 2010
    ..We recently reported that the triplicate complex NR2A-PSD-95-Src is a signaling module to facilitate NMDA receptor over-activation...
  100. pmc Learning induces neurotrophin signaling at hippocampal synapses
    Lulu Y Chen
    Department of Anatomy and Neurobiology, University of California, Irvine, CA 92697, USA
    Proc Natl Acad Sci U S A 107:7030-5. 2010
    ..in this regard than other stimulation patterns, preferentially engaged NMDA receptors that, in turn, activated Src kinases...
  101. pmc Decay accelerating factor (CD55) protects neuronal cells from chemical hypoxia-induced injury
    Ying Wang
    Department of Cellular Injury, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA
    J Neuroinflammation 7:24. 2010
    ..The present study investigates the ability of DAF to protect primary cultured neuronal cells subjected to sodium cyanide (NaCN)-induced hypoxia from degeneration and apoptosis...

Research Grants4

  1. PI/PLC FUNCTION IN PREGNANT RAT MYOMETRIUM
    Mark Phillippe; Fiscal Year: 2002
    ..s. ..
  2. PHOSPHORYLATION IN RENAL CELL INJURY
    Goutam Ghosh Choudhury; Fiscal Year: 2004
    ..These studies will identify important signaling mechanisms involved in glomerular pathology and help to establish effective therapeutic modalities for treatment of proliferative forms of GN. ..
  3. Chemokines, nitric oxide, and myocardial depression
    Bysani Chandrasekar; Fiscal Year: 2005
    ..The results from these studies will further our knowledge of chemokine biology and lead to new therapeutic strategies to prevent or treat myocardial dysfunction in ischemia-reperfusion injury. ..
  4. Thrombin-Stimulated Intrauterine Signaling Pathway
    Mark Phillippe; Fiscal Year: 2007
    ..These studies are anticipated to significantly improve our understanding of the mechanisms underlying preterm labor in the presence of intrauterine infection. ..