Spp1

Summary

Gene Symbol: Spp1
Description: secreted phosphoprotein 1
Alias: OSP, osteopontin, SPP-1, Sialoprotein (osteopontin), bone sialoprotein 1, osteopontin-like
Species: rat

Top Publications

  1. doi Positive regulation of the Egr-1/osteopontin positive feedback loop in rat vascular smooth muscle cells by TGF-beta, ERK, JNK, and p38 MAPK signaling
    Hong wei Yu
    Department of Cardiology, The First Affiliated Hospital of China Medical University, 155th North of Nanjing Street, Heping block, Shenyang, 110001 Liaoning Province, China
    Biochem Biophys Res Commun 396:451-6. 2010
  2. ncbi Osteopontin plays an important role in the development of medial thickening and neointimal formation
    Kikuo Isoda
    First Department of Internal Medicine, National Defense Medical College, Tokorozawa, Saitama, Japan
    Circ Res 91:77-82. 2002
  3. ncbi Role of osteopontin in cardiac fibrosis and remodeling in angiotensin II-induced cardiac hypertrophy
    Yutaka Matsui
    Department of Cardiovascular Medicine, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Hypertension 43:1195-201. 2004
  4. ncbi UTP induces osteopontin expression through a coordinate action of NFkappaB, activator protein-1, and upstream stimulatory factor in arterial smooth muscle cells
    Marie Ange Renault
    INSERM, U441 Athérosclérose, Bordeaux 33600, France
    J Biol Chem 280:2708-13. 2005
  5. ncbi Comprehensive identification of post-translational modifications of rat bone osteopontin by mass spectrometry
    Mandana Keykhosravani
    CIHR Group in Skeletal Development and Remodeling, School of Dentistry, The University of Western Ontario, London, Ontario, N6A 5C1, Canada
    Biochemistry 44:6990-7003. 2005
  6. ncbi Prognostic significance of plasma osteopontin levels in patients with chronic stable angina
    Piercarlo Minoretti
    Department of Cardiology, Alessandro Manzoni Hospital of Lecco, Italy
    Eur Heart J 27:802-7. 2006
  7. ncbi The expression of osteopontin is increased in vessels with blood-brain barrier impairment
    Y Iwanaga
    Department of Anaesthesiology and Emergency Medicine, Faculty of Medicine, Kagawa University, Kagawa, Japan
    Neuropathol Appl Neurobiol 34:145-54. 2008
  8. ncbi Osteopontin in rat renal fibroblasts: functional properties and transcriptional regulation by aldosterone
    Jun Irita
    Department of Integrated Medicine and Informatics, Ehime University Graduate School of Medicine, Shitsukawa, Toon City, Ehime, 791 0295, Japan
    Hypertension 51:507-13. 2008
  9. pmc The role of osteopontin in the development of albuminuria
    Johan Lorenzen
    Division of Nephrology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Am Soc Nephrol 19:884-90. 2008
  10. doi Differential regulation of osteopontin receptors, CD44 and the alpha(v) and beta(3) integrin subunits, in the rat hippocampus following transient forebrain ischemia
    Wha Sun Kang
    Department of Anatomy, The Catholic University of Korea, Seoul 137 701, Republic of Korea
    Brain Res 1228:208-16. 2008

Scientific Experts

Detail Information

Publications110 found, 100 shown here

  1. doi Positive regulation of the Egr-1/osteopontin positive feedback loop in rat vascular smooth muscle cells by TGF-beta, ERK, JNK, and p38 MAPK signaling
    Hong wei Yu
    Department of Cardiology, The First Affiliated Hospital of China Medical University, 155th North of Nanjing Street, Heping block, Shenyang, 110001 Liaoning Province, China
    Biochem Biophys Res Commun 396:451-6. 2010
    ..loop in rat vascular smooth muscle cells (VSMCs) in which early growth response factor-1 (Egr-1) binds to the osteopontin (OPN) promoter and upregulates OPN expression, and OPN upregulates Egr-1 expression via the extracellular ..
  2. ncbi Osteopontin plays an important role in the development of medial thickening and neointimal formation
    Kikuo Isoda
    First Department of Internal Medicine, National Defense Medical College, Tokorozawa, Saitama, Japan
    Circ Res 91:77-82. 2002
    b>Osteopontin (OPN) is a soluble secreted phosphoprotein that binds with high affinity to several integrins and it has been found at the site of atherosclerotic lesions...
  3. ncbi Role of osteopontin in cardiac fibrosis and remodeling in angiotensin II-induced cardiac hypertrophy
    Yutaka Matsui
    Department of Cardiovascular Medicine, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Hypertension 43:1195-201. 2004
    b>Osteopontin (OPN) is upregulated in several experimental models of cardiac fibrosis and remodeling. However, its direct effects remain unclear...
  4. ncbi UTP induces osteopontin expression through a coordinate action of NFkappaB, activator protein-1, and upstream stimulatory factor in arterial smooth muscle cells
    Marie Ange Renault
    INSERM, U441 Athérosclérose, Bordeaux 33600, France
    J Biol Chem 280:2708-13. 2005
    b>Osteopontin (OPN) is an important chemokinetic agent for several cell types. Our earlier studies have shown that its expression is essential for uridine triphosphate (UTP)-mediated migration of vascular smooth muscle cells...
  5. ncbi Comprehensive identification of post-translational modifications of rat bone osteopontin by mass spectrometry
    Mandana Keykhosravani
    CIHR Group in Skeletal Development and Remodeling, School of Dentistry, The University of Western Ontario, London, Ontario, N6A 5C1, Canada
    Biochemistry 44:6990-7003. 2005
    b>Osteopontin (OPN) is a highly modified protein that is found in many tissues and has been associated with a variety of physiological and pathological processes...
  6. ncbi Prognostic significance of plasma osteopontin levels in patients with chronic stable angina
    Piercarlo Minoretti
    Department of Cardiology, Alessandro Manzoni Hospital of Lecco, Italy
    Eur Heart J 27:802-7. 2006
    Levels of the secreted glycophosphoprotein osteopontin (OPN) have been associated with the presence and extent of coronary artery disease (CAD)...
  7. ncbi The expression of osteopontin is increased in vessels with blood-brain barrier impairment
    Y Iwanaga
    Department of Anaesthesiology and Emergency Medicine, Faculty of Medicine, Kagawa University, Kagawa, Japan
    Neuropathol Appl Neurobiol 34:145-54. 2008
    ..In this study, we examined changes of gene expression in the BBB-damaged vessels of SHRSP...
  8. ncbi Osteopontin in rat renal fibroblasts: functional properties and transcriptional regulation by aldosterone
    Jun Irita
    Department of Integrated Medicine and Informatics, Ehime University Graduate School of Medicine, Shitsukawa, Toon City, Ehime, 791 0295, Japan
    Hypertension 51:507-13. 2008
    b>Osteopontin (OPN), a proinflammatory cytokine, plays an important role in renal fibrosis. We reported that plasma OPN levels were higher in patients with primary aldosteronism than with essential hypertension...
  9. pmc The role of osteopontin in the development of albuminuria
    Johan Lorenzen
    Division of Nephrology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Am Soc Nephrol 19:884-90. 2008
    Several gene array studies have suggested that osteopontin (Opn) expression strongly correlates with albuminuria and glomerular disease...
  10. doi Differential regulation of osteopontin receptors, CD44 and the alpha(v) and beta(3) integrin subunits, in the rat hippocampus following transient forebrain ischemia
    Wha Sun Kang
    Department of Anatomy, The Catholic University of Korea, Seoul 137 701, Republic of Korea
    Brain Res 1228:208-16. 2008
    ..regulation of CD44 and the alpha(v)beta(3) integrin subunits, which have been identified as receptors for osteopontin (OPN), in the rat hippocampus following transient forebrain ischemia...
  11. doi Angiotensin II-induced osteopontin expression in vascular smooth muscle cells involves Gq/11, Ras, ERK, Src and Ets-1
    Keiko Abe
    Department of Medicine and Molecular Science, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima, Japan
    Hypertens Res 31:987-98. 2008
    Recent studies suggest that osteopontin (OPN) plays a critical role in the progression of atherosclerotic plaques and that angiotensin II (Ang II) is a potent upregulator of OPN expression...
  12. ncbi Upregulation of osteopontin gene expression in diabetic rat proximal tubular cells revealed by microarray profiling
    T J Hsieh
    Research Centre, Centre Hospitalier de l Universite de Montreal Hotel Dieu, Montreal, Quebec, Canada
    Kidney Int 69:1005-15. 2006
    ..b>Osteopontin (OPN) mRNA expression was quantified by real time-quantitative polymerase chain reaction (RT-qPCR) or ..
  13. ncbi Osteopontin transcription in aortic vascular smooth muscle cells is controlled by glucose-regulated upstream stimulatory factor and activator protein-1 activities
    Miri Bidder
    Division of Bone and Mineral Diseases, Department of Internal Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 277:44485-96. 2002
    The expression of the matrix cytokine osteopontin (OPN) is up-regulated in aortic vascular smooth muscle cells (VSMCs) by diabetes...
  14. ncbi Gene expression profiling of cathepsin D, metallothioneins-1 and -2, osteopontin, and tenascin-C in a mouse spinal cord injury model by cDNA microarray analysis
    Masayuki Hashimoto
    Department of Orthopedic Surgery, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ku, 260 8677, Chiba, Japan
    Acta Neuropathol 109:165-80. 2005
    ..Cathepsin D, metallothionein-1 (MT-1), metallothionein-2 (MT-2), osteopontin (OPN), and tenascin-C were selected for quantitative and histological analysis...
  15. ncbi Increased expression of osteopontin gene in atypical teratoid/rhabdoid tumor of the central nervous system
    Chung Lan Kao
    Department of Physical Medicine and Rehabilitation, Taipei Veterans General Hospital, Taiwan, ROC
    Mod Pathol 18:769-78. 2005
    ..The osteopontin gene was found specifically upregulated in atypical teratoid/rhabdoid tumor cells...
  16. ncbi Aprt/Opn double knockout mice: osteopontin is a modifier of kidney stone disease severity
    Hilary J Vernon
    Department of Genetics, Rutgers University, Piscataway, New Jersey 08854 8082, USA
    Kidney Int 68:938-47. 2005
    b>Osteopontin (OPN) is reported to have two distinct functions in kidney disease: Promotion of inflammation at sites of tissue injury, and inhibition of calcium oxalate monohydrate stone formation...
  17. ncbi Increased expression of osteopontin in the brain with scrapie infection
    Jae Kwang Jin
    Ilsong Institute of Life Science, Hallym University, Ilsong Building, 1605 4 Kwanyang dong, Dongan Gu, Anyang, Kyonggi do 431 060, South Korea
    Brain Res 1072:227-33. 2006
    The expression of osteopontin (OPN) was studied in the brains of mice with scrapie...
  18. ncbi Osteopontin expression in coculture of differentiating rat fetal skeletal fibroblasts and myoblasts
    Renata O Pereira
    Laboratório de Cultura de Células, Departamento de Histologia e Embriologia, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, RJ, Brasil
    In Vitro Cell Dev Biol Anim 42:4-7. 2006
    ..Controlling this process is a complex set of interactions between myoblasts and the extracellular matrix. Osteopontin (OPN) is an acidic, phosphorylated matrix protein that contains an Arg-Gly-Asp (RGD) cell attachment sequence ..
  19. ncbi Function and regulation of osteopontin in response to mechanical stress
    Shinji Fujihara
    Department of Orthodontics and Dentofacial Orthopedics, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan
    J Bone Miner Res 21:956-64. 2006
    ..Analysis of OPN promoter transgenic mice showed the mechanical stress response element(s) in the 5.5-kb upstream region. These results were also obtained with the primary cultured cells...
  20. pmc Molecular mechanisms linking wound inflammation and fibrosis: knockdown of osteopontin leads to rapid repair and reduced scarring
    Ryoichi Mori
    Department of Physiology, School of Medical Sciences, University of Bristol, Bristol BS8 1TD, UK
    J Exp Med 205:43-51. 2008
    Previous studies of tissue repair have revealed osteopontin (OPN) to be up-regulated in association with the wound inflammatory response. We hypothesize that OPN may contribute to inflammation-associated fibrosis...
  21. ncbi Plasma concentrations of matrix metalloproteinase-2, tissue inhibitor of metalloproteinase-1 and osteopontin reflect severity of heart failure in DOCA-salt hypertensive rat
    Frank Kramer
    Institute for Target Discovery Biomarker, Bayer HealthCare AG, Wuppertal, Germany
    Biomarkers 13:270-81. 2008
    ..soluble, heart-derived MMPs and TIMPs in plasma, as well as the determination of the emerging fibrosis marker osteopontin (OPN) might be valuable tools for detecting heart fibrosis...
  22. doi Interferon-induced transmembrane 3 binds osteopontin in vitro: expressed in vivo IFITM3 reduced OPN expression
    M K El-Tanani
    Centre of Cancer Research and Cell Biology CCRCB, Queen s University Belfast, Belfast, UK
    Oncogene 29:752-62. 2010
    b>Osteopontin is a secreted, integrin-binding and phosphorylated acidic glycoprotein, which has an important role in tumour progression...
  23. ncbi Spatial and temporal changes of osteopontin in oxygen-glucose-deprived hippocampal slice cultures
    Ji Yeon Lee
    Department of Anatomy, College of Medicine, The Catholic University of Korea, Seoul, Korea
    Acta Neurobiol Exp (Wars) 70:1-12. 2010
    We have examined the temporal changes and cellular localization of osteopontin (OPN) mRNA and protein in organotypic hippocampal slice cultures subjected to ischemia-like oxygen-glucose deprivation (OGD)...
  24. ncbi [Expressions of interleukin-15 and osteopontin mRNA in early stage of acute rejection of renal allograft in rats]
    Jun Ouyang
    Department of Urology, First Affiliated Hospital, Soochow University, Suzhou 215006, China
    Zhonghua Yi Xue Za Zhi 90:698-702. 2010
    To study the expressions of interleukin-15 (IL-15), osteopontin (OPN), granzyme B (GraB) and perforin (PFP) mRNA in early stage of acute rejection (AR) of renal allograft in rats.
  25. doi Superoxide dismutase mimetic drug tempol aggravates anti-GBM antibody-induced glomerulonephritis in mice
    Hua Lu
    Department of Pathology, Univ of Texas Southwestern Medical Center, Dallas, TX 75390 9073, USA
    Am J Physiol Renal Physiol 299:F445-52. 2010
    ..MDA), H(2)O(2), and immunohistochemical staining for neutrophils, lymphocytes, macrophages, p65-NF-kappaB, and osteopontin were performed...
  26. pmc Blockade of osteopontin inhibits glomerular fibrosis in a model of anti-glomerular basement membrane glomerulonephritis
    Cindy Zhou
    Department of Diagnostic Sciences DB, University of Texas Health Science Center at Houston, USA
    Am J Nephrol 32:324-31. 2010
    In our rat model for anti-GBM GN, severe fibrosis follows glomerular inflammation. A potential role of extracellular matrix protein osteopontin (OPN) in glomerular fibrosis was investigated.
  27. doi Osteopontin: correlation with phagocytosis by brain macrophages in a rat model of stroke
    Yoo Jin Shin
    Department of Anatomy, Integrative Research Support Center, College of Medicine, The Catholic University of Korea, 137 701, Seoul, Korea
    Glia 59:413-23. 2011
    b>Osteopontin (OPN) is an adhesive glycoprotein linked to a variety of pathophysiological processes...
  28. doi Localization of osteopontin and osterix in periodontal tissue during orthodontic tooth movement in rats
    Ji Youn Kim
    a PhD student, Department of Oral Anatomy and Developmental Biology, Division of Dentistry, Graduate School, Kyung Hee University, Seoul, Korea
    Angle Orthod 82:107-14. 2012
    To evaluate the localization of osteopontin (OPN) and osterix in periodontal tissue during experimental tooth movement with heavy force in rats.
  29. doi Osteopontin is involved in urotensin II-induced migration of rat aortic adventitial fibroblasts
    Yong gang Zhang
    Department of Cardiovascular Diseases, First Affiliated Hospital, Shantou University Medical College, Shantou 515041, China
    Peptides 32:2452-8. 2011
    Recent studies suggest that both osteopontin and urotensin II (UII) play critical roles in vascular remodeling. We previously showed that UII could stimulate the migration of aortic adventitial fibroblasts...
  30. doi Osteocalcin- and osteopontin-containing neurons in the rat hind brain
    Toshihiko Suzuki
    Division of Oral and Craniofacial Anatomy, Graduate School of Dentistry, Tohoku University, Sendai, Miyagi, 980 8575, Japan
    Cell Mol Neurobiol 32:1265-73. 2012
    Immunohistochemistry for osteocalcin (OC) and osteopontin (OPN) was performed to know their distributions in the hind brain of adult rats...
  31. doi Osteopontin is upregulated after mechanical brain injury and stimulates neurite growth from hippocampal neurons through β1 integrin and CD44
    Stefan Plantman
    Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
    Neuroreport 23:647-52. 2012
    ..b>Osteopontin (OPN), a glycosylated phosphoprotein, can be found in both the soluble form and as an extracellular matrix ..
  32. pmc Dynamic light scattering study of inhibition of nucleation and growth of hydroxyapatite crystals by osteopontin
    John R de Bruyn
    Department of Physics and Astronomy, University of Western Ontario, London, Ontario, Canada
    PLoS ONE 8:e56764. 2013
    We study the effect of isoforms of osteopontin (OPN) on the nucleation and growth of crystals from a supersaturated solution of calcium and phosphate ions...
  33. pmc miR181a protects against angiotensin II-induced osteopontin expression in vascular smooth muscle cells
    Ebony Washington Remus
    Division of Cardiology, Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
    Atherosclerosis 228:168-74. 2013
    b>Osteopontin (OPN) is a multifunctional protein found in abundance in atherosclerotic plaques. Angiotensin II (Ang II) promotes atherosclerosis by inducing adhesion and migration of vascular smooth muscle cells (VSMCs)...
  34. doi Prevention of neointimal hyperplasia in balloon-injured rat carotid artery via small interference RNA mediated downregulation of osteopontin gene
    Jian Xu
    Department of Cardiology, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning, China
    Mol Cell Biochem 377:1-10. 2013
    The aim of the present study was to take osteopontin (OPN) as molecular target to study its effects on injured intima model of carotid artery in rat using perivascular transfer of OPN-small interference RNA (siRNA)...
  35. doi Osteopontin mediating cyclosporine A induced epithelial-to-mesenchymal transition on rat renal tubular epithelial cells
    Dongliang Xu
    Department of Urology, The First People s Hospital Affiliated to Shanghai Jiao Tong University, Shanghai First People s Hospital, 100 Haining Road, Shanghai, 200080, China
    Cell Biol Int 38:8-15. 2014
    b>Osteopontin (OPN) is highly correlated with cyclosporine A (CsA) nephrotoxicity...
  36. doi Participation of bone morphogenetic protein (BMP)-6 and osteopontin in cisplatin (CDDP)-induced rat renal fibrosis
    Ryo Yano
    Veterinary Pathology, Graduate School of Life and Environmental Sciences, Osaka Prefecture University, 1 58 Rinku Ourai Kita, Izumisano City, Osaka 598 8531, Japan
    Exp Toxicol Pathol 67:99-107. 2015
    The significance of bone morphogenetic protein (BMP)-6 and osteopontin (OPN) in renal fibrosis is poorly understood. We investigated the expression of BMP-6 and OPN in cisplatin (CDDP; 6mg/kg, once, i.p...
  37. ncbi Synthesis and processing of bone sialoproteins during de novo bone formation in vitro
    X L Zhu
    Canadian Institutes of Health Research Group in Matrix Dynamics, Faculty of Dentistry, University of Toronto, ON
    Biochem Cell Biol 79:737-46. 2001
    Bone sialoprotein (BSP) and osteopontin (OPN) are sulphated and phosphorylated sialoglycoproteins that regulate the formation of hydroxyapatite crystals during de novo bone formation...
  38. ncbi Osteopontin is released from the heart into the coronary circulation in patients with a previous anterior wall myocardial infarction
    Akira Tamura
    Second Department of Internal Medicine, Oita Medical University, Oita, Japan
    Circ J 67:742-4. 2003
    The present study was designed to clarify whether osteopontin, an extracellular matrix protein, is released from the heart into the coronary circulation in patients with a previous (>3 months) anterior wall myocardial infarction (MI)...
  39. ncbi Circulating interleukin-18 and osteopontin are useful to evaluate disease activity in patients with tuberculosis
    Shin Ichiro Inomata
    Third Department of Internal Medicine, Sapporo Medical University School of Medicine, Japan
    Cytokine 30:203-11. 2005
    ..T helper type 1 (Th1) responses have been implicated in the protective immunity, pathophysiology and development of tuberculosis. However, it is still unclear which molecule(s) reflect disease activity in patients with tuberculosis...
  40. ncbi Proteomic-based discovery and characterization of glycosylated eosinophil-derived neurotoxin and COOH-terminal osteopontin fragments for ovarian cancer in urine
    Bin Ye
    Laboratory of Gynecologic Oncology, Department of Obstetrics and Gynecology and Reproductive Biology, Brigham and Women s Hospital, Harvard Medical School, Dana Farber Cancer Center, 221 Longwood Avenue, LMRC 601B, Boston, MA 02115, USA
    Clin Cancer Res 12:432-41. 2006
    ..The objective was to identify and characterize low molecular weight proteins/peptides in urine and their posttranslational modifications that might be used as a screening tool for ovarian cancer...
  41. ncbi An evaluation of tumor oxygenation and gene expression in patients with early stage non-small cell lung cancers
    Quynh Thu Le
    Department of Radiation Oncology, Stanford University Medical Center, Stanford, California 94305 5847, USA
    Clin Cancer Res 12:1507-14. 2006
    ..To directly assess tumor oxygenation in resectable non-small cell lung cancers (NSCLC) and to correlate tumor pO2 and the selected gene and protein expression to treatment outcomes...
  42. ncbi BRCA1 suppresses osteopontin-mediated breast cancer
    Mohamed K El-Tanani
    Centre for Cancer Research and Cell Biology, Queen s University Belfast, Grosvenor Road, Belfast BT12 6BJ, Northern Ireland, United Kingdom
    J Biol Chem 281:26587-601. 2006
    ..Here we show in a rat mammary model system that wild type (WT) BRCA1 specifically represses the expression of osteopontin (OPN), a multifunctional estrogen-responsive gene implicated in oncogenic transformation, particularly that of ..
  43. ncbi [Expression and implication of osteopontin in renal cortex of diabetic rats]
    Yan Ping Cao
    Department of Pathology, Hebei Medical University, Shijiazhuang 050017, Hebei, China
    Zhongguo Wei Zhong Bing Ji Jiu Yi Xue 20:287-90. 2008
    To investigate the expression and implication of osteopontin (OPN) in renal cortex of diabetic rats.
  44. doi Matrix vesicles are carriers of bone morphogenetic proteins (BMPs), vascular endothelial growth factor (VEGF), and noncollagenous matrix proteins
    Niru N Nahar
    Department of Pathology, University of Kansas Medical Center, 3901 Rainbow Blvd, Kansas City, KS 66160, USA
    J Bone Miner Metab 26:514-9. 2008
    ..morphogenetic protein (BMP)-1 through-7, VEGF, and the noncollagenous matrix proteins, bone sialoprotein (BSP), osteopontin (OPN), osteocalcin (OC), and osteonectin (ON) in isolated rat growth plate MVs...
  45. ncbi Regulation of osteopontin and related proteins in rat CC531 colorectal cancer cells
    Rania Georges
    Toxicology and Chemotherapy Unit, German Cancer Research Center DKFZ, D 69120 Heidelberg, Germany
    Int J Oncol 37:249-56. 2010
    ..These included osteopontin (OPN), bone sialoprotein ll (BSP ll), Runx2, Hoxc8, matrix metalloprotease-7 (MMP-7) and matrix-metalloprotease-..
  46. pmc Osteopontin signals through calcium and nuclear factor of activated T cells (NFAT) in osteoclasts: a novel RGD-dependent pathway promoting cell survival
    Natsuko Tanabe
    Department of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, The University of Western Ontario, London N6A5C1, Canada
    J Biol Chem 286:39871-81. 2011
    b>Osteopontin (OPN), an integrin-binding extracellular matrix glycoprotein, enhances osteoclast activity; however, its mechanisms of action are elusive...
  47. ncbi Smooth muscle cells of the media in the dilatative pathology of ascending thoracic aorta: morphology, immunoreactivity for osteopontin, matrix metalloproteinases, and their inhibitors
    V Lesauskaite
    Institute of Cardiology and Department of Biochemistry, Kaunas University of Medicine, Lithuania
    Hum Pathol 32:1003-11. 2001
    ..Ultrastructure of SMCs characteristic of the synthetic phenotype, together with increased expression of osteopontin in the media of pathologic thoracic aortas indicated the transition of SMCs from the contractile to the ..
  48. ncbi Overexpression of the cytokine osteopontin identifies aggressive laryngeal squamous cell carcinomas and enhances carcinoma cell proliferation and invasiveness
    Angela Celetti
    Istituto di Endocrinologia ed Oncologia Sperimentale del Consiglio Nazionale delle Ricerche Dipartimento di Biologia e Patologia Cellulare e Molecolare, University of Naples Federico II, Italy
    Clin Cancer Res 11:8019-27. 2005
    b>Osteopontin is a secreted cytokine that binds to the cell surface CD44v6 receptor...
  49. pmc Uraemic hyperparathyroidism causes a reversible inflammatory process of aortic valve calcification in rats
    Mony Shuvy
    Cardiovascular Research Center, Heart Institute, Hadassah Hebrew University Medical Center, Ein Karem, PO Box 12000, Jerusalem 91120, Israel
    Cardiovasc Res 79:492-9. 2008
    ..Renal failure is associated with aortic valve calcification (AVC). Our aim was to develop an animal model for exploring the pathophysiology and reversibility of AVC, utilizing rats with diet-induced kidney disease...
  50. pmc Effect of NADPH oxidase inhibition on the expression of kidney injury molecule and calcium oxalate crystal deposition in hydroxy-L-proline-induced hyperoxaluria in the male Sprague-Dawley rats
    Jian Zuo
    Department of Pathology, Immunology and Laboratory Medicine, College of Medicine, University of Florida, Gainesville, FL, USA
    Nephrol Dial Transplant 26:1785-96. 2011
    ..We have proposed that oxalate (Ox)- and CaOx crystal-induced injury is most likely caused by reactive oxygen species (ROS) produced by activation of membrane nicotinamide adenine dinucleotide phosphate (NADPH) oxidase...
  51. pmc Spotlight on differentially expressed genes in urinary bladder cancer
    Apostolos Zaravinos
    Laboratory of Virology, Medical School, University of Crete, Heraklion, Crete, Greece
    PLoS ONE 6:e18255. 2011
    ..We previously identified common differentially expressed (DE) genes in bladder cancer (BC). In the present study we analyzed in depth, the expression of several groups of these DE genes...
  52. ncbi Predictive genomic biomarkers for drug-induced nephrotoxicity in mice
    Chiaki Kondo
    Drug Developmental Research Laboratories, Shionogi and Co, Ltd, Osaka, Japan
    J Toxicol Sci 37:723-37. 2012
    ..This study provides novel evidence that these nephrotoxicity biomarker genes identified are translatable to mice, and that they are useful for early and sensitive detection of nephrotoxicity...
  53. ncbi Purification of a human milk protein closely similar to tumor-secreted phosphoproteins and osteopontin
    D R Senger
    Department of Pathology, Beth Israel Hospital, Boston, MA 02215
    Biochim Biophys Acta 996:43-8. 1989
    ..and internal sequences derived from the rat tumor-secreted phosphoprotein indicate that it is identical to rat osteopontin, a bone protein with an Arg-Gly-Asp cell-binding sequence (Oldberg, A., Franzen, A. and Heinegard, D...
  54. pmc Cloning and sequence analysis of rat bone sialoprotein (osteopontin) cDNA reveals an Arg-Gly-Asp cell-binding sequence
    A Oldberg
    Proc Natl Acad Sci U S A 83:8819-23. 1986
    ..To better reflect the potential function of bone sialoprotein--we propose the name "osteopontin" for this protein.
  55. ncbi Secreted phosphoproteins associated with neoplastic transformation: close homology with plasma proteins cleaved during blood coagulation
    D R Senger
    Department of Pathology, Beth Israel Hospital, Boston, Massachusetts 02215
    Cancer Res 48:5770-4. 1988
    ....
  56. ncbi Isolation, characterization, and biosynthesis of a phosphorylated glycoprotein from rat bone
    C W Prince
    J Biol Chem 262:2900-7. 1987
    ..A protein migrating in the same position, on 5-15% SDS-polyacrylamide gel electrophoresis (i.e. with an Mr = 75,000) and on 15% gels (Mr = 45,000), as the phosphoprotein obtained from bone could be specifically immunoprecipitated...
  57. pmc Osteopontin is elevated during neointima formation in rat arteries and is a novel component of human atherosclerotic plaques
    C M Giachelli
    Department of Pathology SJ 60 University of Washington School of Medicine, Seattle 98195
    J Clin Invest 92:1686-96. 1993
    ..In this study, we sequenced the complete cDNA and conclusively identified one of these genes, 2B7, as rat osteopontin. Using immunochemistry and in situ hybridization, we found that medial smooth muscle cells (SMC) in uninjured ..
  58. ncbi The influence of the proinflammatory cytokine, osteopontin, on autoimmune demyelinating disease
    D Chabas
    Department of Neurology and Neurological Sciences, Beckman Center for Molecular Medicine, B002, Stanford, CA 94305, USA
    Science 294:1731-5. 2001
    ..dissected from brains of patients with multiple sclerosis (MS), indicated an abundance of transcripts for osteopontin (OPN)...
  59. ncbi Osteopontin posttranslational modifications, possibly phosphorylation, are required for in vitro bone resorption but not osteoclast adhesion
    S Razzouk
    Department of Basic Sciences, Dental Branch, University of Texas Houston Health Science Center, Houston, TX 77030, USA
    Bone 30:40-7. 2002
    b>Osteopontin (OPN), a phosphorylated bone matrix glycoprotein, is an Arg-Gly-Asp (RGD)-containing protein that interacts with integrins and promotes in vitro attachment of a number of cell types, including osteoclasts...
  60. ncbi Osteopontin gene is expressed in the dermal papilla of pelage follicles in a hair-cycle-dependent manner
    D W Yu
    Epithelial Biology Unit and Ronald O Perelman Department of Dermatology, New York University School of Medicine, New York, NY 10016, USA
    J Invest Dermatol 117:1554-8. 2001
    ..Using the random primer polymerase chain reaction, we have identified an approximately 1.4 kb osteopontin mRNA that is present in large quantities in cultured rat vibrissa dermal papilla cells but undetectable in ..
  61. ncbi Osteopontin induces angiogenesis of murine neuroblastoma cells in mice
    Fumiyuki Takahashi
    Pharmacology Division, National Cancer Center Research Institute, Chuo Ku, Tokyo, Japan
    Int J Cancer 98:707-12. 2002
    Angiogenesis is an essential process for tumor growth and is regulated by tumor-derived angiogenic cytokines. Osteopontin (OPN) is one of the cytokines produced by various tumor cells and is suggested to be involved in angiogenesis by ..
  62. ncbi Osteopontin expression and regulation in the testis, efferent ducts, and epididymis of rats during postnatal development through to adulthood
    Chad C Luedtke
    Department of Anatomy and Cell Biology, McGill University, 3640 University Street, Montreal, Quebec, Canada H3A 2B2
    Biol Reprod 66:1437-48. 2002
    b>Osteopontin (OPN), a multifunctional phosphoprotein found in both hard and soft tissues, was examined in the male reproductive tract...
  63. ncbi Colocalization of intracellular osteopontin with CD44 is associated with migration, cell fusion, and resorption in osteoclasts
    K Suzuki
    CIHR Group in Matrix Dynamics, Faculty of Dentistry, University of Toronto, Canada
    J Bone Miner Res 17:1486-97. 2002
    Although osteopontin (OPN) is recognized generally as a secreted protein, an intracellular form of osteopontin (iOPN), associated with the CD44 complex, has been identified in migrating fibroblastic cells...
  64. ncbi Differential regulation of osteopontin expression in the clipped and nonclipped kidney of two-kidney, one-clip hypertensive rats
    Stefan Gauer
    Funktionsbereich Nephrologie, Medizinische Klinik IV, Zentrum der Inneren Medizin, Johann Wolfgang Goethe Universitat, Frankfurt am Main, Germany
    Am J Hypertens 16:214-22. 2003
    b>Osteopontin (Opn) is highly upregulated in many different animal models of renal disease, where it is suspected to participate in progression of the disease...
  65. ncbi Osteopontin inhibits interleukin-1beta-stimulated increases in matrix metalloproteinase activity in adult rat cardiac fibroblasts: role of protein kinase C-zeta
    Zhonglin Xie
    Department of Physiology, James H Quillen College of Medicine, James H Quillen Veterans Affairs Medical Center, East Tennessee State University, Johnson City, Tennessee 37614, USA
    J Biol Chem 278:48546-52. 2003
    We have shown that osteopontin (OPN), an extracellular matrix protein, plays an important role in post myocardial infarction (MI) remodeling by promoting collagen synthesis and accumulation...
  66. ncbi Spinal root avulsion-induced upregulation of osteopontin expression in the adult rat spinal cord
    Yonghui Fu
    Department of Orthopaedic Surgery, 2nd Clinical College of China Medical University, Shenyang, China
    Acta Neuropathol 107:8-16. 2004
    b>Osteopontin (OPN) is a secretory adhesive glycoprotein that is expressed in various tissues and plays a role in inflammation and tissue repair...
  67. ncbi Hypoxia-responsive growth factors upregulate periostin and osteopontin expression via distinct signaling pathways in rat pulmonary arterial smooth muscle cells
    Peng Li
    Vascular Biology and Hypertension Program, Division of Cardiovascular Disease, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    J Appl Physiol (1985) 97:1550-8; discussion 1549. 2004
    This study tested the hypothesis that expression of the novel adhesion molecule periostin (PN) and osteopontin (OPN) is increased in lung and in isolated pulmonary arterial smooth muscle cells (PASMCs) in response to the stress of ..
  68. ncbi Phosphate-induced vascular calcification: role of pyrophosphate and osteopontin
    Koba A Lomashvili
    Renal Division, Department of Medicine, Emory University, 1639 Pierce Drive, Atlanta, GA, USA
    J Am Soc Nephrol 15:1392-401. 2004
    ..This effect of alkaline phosphatase was not due to dephosphorylation of osteopontin (OPN), and calcification was not increased in aortas from OPN-deficient mice...
  69. ncbi Differential allele expression of host defense genes, pulmonary surfactant protein-A and osteopontin, in rat
    Zhenwu Lin
    Department of Cellular and Molecular Physiology, College of Medicine, The Pennsylvania State University, H166, 500 University Drive, Hershey, PA 17033, USA
    Mol Immunol 41:1155-65. 2004
    ..We conclude that allele-specific expression occurs among genes of innate host defense. This may yet provide another level of regulatory complexity for molecules involved in the first line of defense...
  70. ncbi Upregulation of osteopontin in Schwann cells of the sciatic nerves of Lewis rats with experimental autoimmune neuritis
    Meejung Ahn
    Department of Veterinary Medicine, Cheju National University, Jeju 690 756, South Korea
    Neurosci Lett 372:137-41. 2004
    We examined the expression of osteopontin (OPN) in the sciatic nerves of rats with experimental autoimmune neuritis (EAN), using immunohistochemistry and immunoblotting, to study its involvement in the pathogenesis of autoimmune ..
  71. ncbi In vitro and in vivo effects of the overexpression of osteopontin on osteoblast differentiation using a recombinant adenoviral vector
    Hiroko Kojima
    Age Dimension Research Center, National Institute of Advanced Industrial Science and Technology AIST, Tsukuba Central 6, Tsukuba 305 8566, Japan
    J Biochem 136:377-86. 2004
    b>Osteopontin (OPN) is a highly acidic secreted phosphoprotein that binds to cells via an RGD (arginine-glycine-aspartic acid) cell adhesion sequence that recognizes the alphaVbeta3 integrin...
  72. ncbi Osteopontin, a macrophage-derived matricellular glycoprotein, inhibits axon outgrowth
    Patrick Küry
    Department of Neurology, Heinrich Heine University, Dusseldorf, Germany
    FASEB J 19:398-400. 2005
    ..In this study, we addressed a possible role of the matricellular glycoprotein osteopontin (OPN) using crush lesions of the optic and sciatic nerve as models of central and peripheral axotomy, ..
  73. ncbi Osteopontin expression in proliferated bile ductules: the correlation with liver damage in fulminant hepatitis
    Takuma Tajiri
    Division of Gastroenterology, Showa University Fujigaoka Hospital, Yokohama 227 8501, Japan
    Dig Dis Sci 50:188-95. 2005
    ..of hepatic necrosis caused by fulminant hepatitis; however, the relation between proliferated bile ductules and osteopontin (OPN) expression in inflamed areas in each of the clinical forms of fulminant hepatitis has not been described...
  74. ncbi The dioxin/aryl hydrocarbon receptor mediates downregulation of osteopontin gene expression in a mouse model of gastric tumourigenesis
    Nikolai V Kuznetsov
    InDex Pharmaceuticals AB, Scheeles vag 1, S 171 77 Stockholm, Sweden
    Oncogene 24:3216-22. 2005
    ..In the glandular stomach of CA-AhR mice, we observed decreased mRNA expression of osteopontin (OPN), a noncollagenous protein of bone matrix that is also involved in several important functions including ..
  75. ncbi Dietary genistein improves survival and reduces expression of osteopontin in the prostate of transgenic mice with prostatic adenocarcinoma (TRAMP)
    Roycelynn Mentor-Marcel
    Department of Pharmacology Toxicology, University of Alabama at Birmingham School of Medicine, 35294, USA
    J Nutr 135:989-95. 2005
    Studies in vitro suggest that osteopontin (OPN), an extracellular matrix protein secreted by macrophages infiltrating prostate tumors, and by tumor cells, may have a role in the transition from clinically insignificant tumors to ..
  76. ncbi SNPs in the promoter region of the osteopontin gene as a marker predicting the efficacy of interferon-based therapies in patients with chronic hepatitis C
    Masashi Naito
    Division of Gastroenterology and Hepatology, Internal Medicine, Saitama Medical School, 38 Morohongo, Moroyama cho, Iruma gun, Saitama 350 0495, Japan
    J Gastroenterol 40:381-8. 2005
    ..b>Osteopontin is a cytokine crucial for the initiation of the Th1 response...
  77. ncbi Osteopontin gene haplotypes correlate with multiple sclerosis development and progression
    Annalisa Chiocchetti
    Interdisciplinary Research Center of Autoimmune Diseases IRCAD and Department of Medical Sciences, A Avogadro University of Eastern Piedmont, Via Solaroli 17, I 28100 Novara, Italy
    J Neuroimmunol 163:172-8. 2005
    b>Osteopontin (OPN) is an inflammatory cytokine highly expressed in multiple sclerosis (MS) plaques...
  78. ncbi Osteopontin influences the invasiveness of pancreatic cancer cells and is increased in neoplastic and inflammatory conditions
    A Kolb
    Department of General Surgery, University of Heidelberg, Germany
    Cancer Biol Ther 4:740-6. 2005
    ..Invasive tumor growth and early metastasis are two important reasons for this dismal prognosis. Osteopontin (OPN) is a secretory protein with a variety of functions, for example in cell adhesion and migration, ..
  79. ncbi Osteopontin is overexpressed in human papillary thyroid carcinomas and enhances thyroid carcinoma cell invasiveness
    Valentina Guarino
    Dipartimento di Biologia e Patologia Cellulare e Molecolare, Facolta di Medicina e Chirurgia, Universita di Napoli Federico II, Via S Pansini 5, 80131 Naples, Italy
    J Clin Endocrinol Metab 90:5270-8. 2005
    ..We previously reported that osteopontin (OPN), a secreted glycoprotein that functions as a ligand for CD44v6, is overexpressed in thyrocytes ..
  80. ncbi Nitric oxide-dependent osteopontin expression induces metastatic behavior in HepG2 cells
    Hongtao Guo
    Department of Surgery, Duke University Medical Center, Durham, North Carolina 27710, USA
    Dig Dis Sci 50:1288-98. 2005
    Our objective was to delineate the role of nitric oxide (NO) in osteopontin (OPN)-associated metastatic properties in HepG2 cells...
  81. ncbi A polymorphism of the osteopontin gene is related to urinary calcium stones
    Bing Gao
    Department of Nephro urology, Nagoya City University Graduate School of Medical Sciences, Kawasumi, Nagoya, Japan
    J Urol 174:1472-6. 2005
    We investigated polymorphisms of the osteopontin (OPN) gene to explore whether they could be used as a gene marker for determining the risk of urinary calcium stones.
  82. ncbi Regulation of bone sialoprotein (BSP) gene transcription by lipopolysaccharide
    Naoko Kato
    Department of Periodontology, Nihon University School of Dentistry at Matsudo, Chiba, 271 8587, Japan
    J Cell Biochem 97:368-79. 2006
    ..These studies, therefore, show that LPS suppresses BSP gene transcription through PKA and tyrosine kinase-dependent pathways and that the LPS effects are mediated through CRE and FRE elements in the proximal BSP gene promoter...
  83. ncbi Human myeloma cells express the bone regulating gene Runx2/Cbfa1 and produce osteopontin that is involved in angiogenesis in multiple myeloma patients
    S Colla
    Hematology and BMT Center, University of Parma, Parma, Italy
    Leukemia 19:2166-76. 2005
    b>Osteopontin (OPN) is a multifunctional bone matrix glycoprotein that is involved in angiogenesis, cell survival and tumor progression...
  84. ncbi FGF upregulates osteopontin in epiphyseal growth plate chondrocytes: implications for endochondral ossification
    S Weizmann
    Institute of Animal Science, The Volcani Center, Bet Dagan 50250, Israel
    Matrix Biol 24:520-9. 2005
    ..ligand for FGFR3 rapidly induces the upregulation and secretion of the matrix resident phosphoprotein, osteopontin (OPN) in cultured chicken chondrocytes...
  85. ncbi High plasma levels of osteopontin in patients with restenosis after percutaneous coronary intervention
    Ryuichi Kato
    Arterioscler Thromb Vasc Biol 26:e1-2. 2006
  86. ncbi Osteopontin: a rapid and sensitive response to dioxin exposure in the osteoblastic cell line UMR-106
    Carolina Wejheden
    Division of Biochemical Toxicology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
    Biochem Biophys Res Commun 341:116-20. 2006
    ..b>Osteopontin (OPN) is an adhesion protein, suggested to be important in bone remodeling and our results indicate that TCDD ..
  87. ncbi Integrin-linked kinase regulates osteopontin-dependent MMP-2 and uPA expression to convey metastatic function in murine mammary epithelial cancer cells
    Zhiyong Mi
    Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA
    Carcinogenesis 27:1134-45. 2006
    ..b>Osteopontin (OPN) overexpression may represent a key molecular event in cancer metastasis...
  88. pmc Osteopontin participates in Th1-mediated host resistance against nonlethal malaria parasite Plasmodium chabaudi chabaudi infection in mice
    Yoshimasa Maeno
    Department of Virology and Parasitology, Fujita Health University School of Medicine, 1 98 Kutsukake, Toyoake, Aichi 470 1192, Japan
    Infect Immun 74:2423-7. 2006
    b>Osteopontin (OPN) knockout mice (OPN-KO mice) died of Plasmodium chabaudi chabaudi infection, although wild-type (WT) mice had self-limiting infections. OPN was detected in the WT mice at 2 days postinfection...
  89. ncbi Expression pattern of osteopontin in endometrial carcinoma: correlation with expression of the adhesion molecule CEACAM1
    Juliane Briese
    Department of Pathology, University Clinic Hamburg Eppendorf, Hamburg, Germany
    Int J Gynecol Pathol 25:161-9. 2006
    b>Osteopontin (OPN) and CEACAM1 have diverse biological functions in the uterus and placenta throughout the estrous cycle and pregnancy and have been shown to interact with integrin beta3...
  90. pmc Osteopontin expression in intratumoral astrocytes marks tumor progression in gliomas induced by prenatal exposure to N-ethyl-N-nitrosourea
    Taichang Jang
    Department of Neurology and Clinical Neurosciences, Stanford University Medical School, Stanford, California 94305 5487, USA
    Am J Pathol 168:1676-85. 2006
    ..Our analysis identified osteopontin (OPN) as the most up-regulated gene in glioma...
  91. pmc Tubulointerstitial macrophage accumulation is regulated by sequentially expressed osteopontin and macrophage colony-stimulating factor: implication for the role of atorvastatin
    Shaojiang Tian
    Division of Nephrology, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, China
    Mediators Inflamm 2006:12919. 2006
    ..Unilateral ureteral obstructive (UUO) rats were treated with atorvastatin (10 mg/Kg) or vehicle. Expression of osteopontin (OPN) and macrophage colony-stimulating factor (M-CSF) was evaluated by RT-PCR and immunohistochemistry...
  92. ncbi Osteopontin expression in activated glial cells following mechanical- or toxin-induced nigral dopaminergic cell loss
    Joanna Iczkiewicz
    Neurodegenerative Diseases Research Centre, School of Health and Biomedical Sciences, King s College, London SE1 1UL, UK
    Exp Neurol 207:95-106. 2007
    b>Osteopontin (OPN) is a glycosylated phosphoprotein that regulates both oxidative stress and inflammatory processes...
  93. ncbi Blockade of integrin beta3-FAK signaling pathway activated by osteopontin inhibits neointimal formation after balloon injury
    Mei Han
    Department of Biochemistry and Molecular Biology, Hebei Medical University, Shijiazhuang, China
    Cardiovasc Pathol 16:283-90. 2007
    b>Osteopontin (OPN) promotes the migration and adhesion of vascular smooth muscle cells (VSMCs) through cell surface receptor, integrin beta3...
  94. pmc Adhesion of MC3T3-E1 cells to bone sialoprotein and bone osteopontin specifically bound to collagen I
    Matthew T Bernards
    Department of Chemical Engineering, University of Washington, Seattle, Washington 98195, USA
    J Biomed Mater Res A 86:779-87. 2008
    Bone sialoprotein (BSP) and bone osteopontin (OPN) are members of the SIBLING (small integrin-binding ligand, N-linked glycoproteins) family of proteins commonly found in mineralized tissues...
  95. doi Expression of osteopontin in the rat retina: effects of excitotoxic and ischemic injuries
    Glyn Chidlow
    Ophthalmic Research Laboratories, South Australian Institute of Ophthalmology, Hanson Institute Centre for Neurological Diseases, Adelaide, SA, Australia
    Invest Ophthalmol Vis Sci 49:762-71. 2008
    The cytokine osteopontin (OPN) has been localized to the retinal ganglion cell layer in the normal rodent retina, prompting the suggestion that it could serve as a useful marker for identifying and quantifying such neurons in models of ..
  96. doi Role of phosphate groups in inhibition of calcium oxalate crystal growth by osteopontin
    Graeme K Hunter
    School of Dentistry and CIHR Group in Skeletal Development and Remodeling, University of Western Ontario, London, Ont, Canada
    Cells Tissues Organs 189:44-50. 2009
    b>Osteopontin (OPN) inhibits the growth of calcium oxalate monohydrate (COM) and other crystal phases in a phosphorylation-dependent manner...
  97. doi Phosphorylation of osteopontin peptides mediates adsorption to and incorporation into calcium oxalate crystals
    Jason O'Young
    School of Dentistry and CIHR Group in Skeletal Development and Remodeling, University of Western Ontario, London, Ont, Canada
    Cells Tissues Organs 189:51-5. 2009
    Phosphorylated peptides of osteopontin (OPN) have been shown to inhibit the growth of the {100} face of calcium oxalate monohydrate (COM). The inhibitory potency has been shown to be dependent on the phosphate content of the peptide...
  98. doi Hydrogen peroxide enhances osteopontin expression and matrix metalloproteinase activity in aortic vascular smooth muscle cells
    Tao Hu
    Deparrment of Cardiology, Xijing Hospital, Fourth Military Medical University, Xi an, China
    Clin Exp Pharmacol Physiol 36:626-30. 2009
    ..The present aim of the present study was to test the hypothesis that reactive oxygen species (ROS) enhance osteopontin (OPN) expression and increase matrix metalloproteinase (MMP)-2 activity (two major factors that contribute to ..
  99. doi Oxidized low-density lipoprotein increases osteopontin expression by generation of oxidative stress
    Cécile Mazière
    Biochemistry Laboratory, CHU Nord, Amiens F 80000, France
    Free Radic Biol Med 48:1382-7. 2010
    b>Osteopontin (OPN) is an important mediator of inflammation and is involved in the generation of atherosclerotic lesions...
  100. doi Inhibitory action of Wnt target gene osteopontin on mitochondrial cytochrome c release determines renal ischemic resistance
    Jose Luis Viñas
    Centro de Investigaciones Biomédicas en Red de Bioingeniería, Biomateriales y Nanomedicina, Barcelona, Spain
    Am J Physiol Renal Physiol 299:F234-42. 2010
    ..and in vitro allowed us to study whether the action of the Wnt pathway on apoptosis through the regulation of osteopontin was critical to the maintenance of inherent ischemic resistance mechanisms...

Research Grants5

  1. TEM with Digital and Cryopreparation Systems
    Andrew Evan; Fiscal Year: 2003
    ..Dr. Richard Gregory will employ immunohistochemistry to examine the role of a Streptococcus mutans 65 kDa fimbrial protein binding as a mechanism for the induction of dental carries. ..
  2. Urine Protein Biomarker Exploration in Ovarian Cancer
    Bin Ye; Fiscal Year: 2006
    ..This project, if successful, could fundamentally shift the approach to the early detection of ovarian cancer and significantly improve the survival rate of cases detected. [unreadable] [unreadable]..
  3. IKSI: 1st Annual International Urolithiasis Research Symposium
    Andrew Evan; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  4. Risk for Renal Injury Caused by Shock Wave Lithotripsy
    Andrew Evan; Fiscal Year: 2008
    ..All of these proposed studies aim at understanding the adverse effects of shock waves and advancing the safety of all stone patients at a time when reports of adverse effects in SWL are on the rise. ..
  5. IKSI: 2nd International Urolithiasis Research Symposium
    Andrew Evan; Fiscal Year: 2008
    ..This assumption was supported by the great success of the 1st International Urolithiasis Research symposium and the high level of interest in the 2nd symposium date. [unreadable] [unreadable] [unreadable]..