Socs1

Summary

Gene Symbol: Socs1
Description: suppressor of cytokine signaling 1
Alias: Cish1, Socs-1, suppressor of cytokine signaling 1, cytokine inducible SH2-containing protein 1
Species: rat

Top Publications

  1. ncbi Leptin resistance of adipocytes in obesity: role of suppressors of cytokine signaling
    Z Wang
    Gifford Laboratories, Touchstone Center for Diabetes Research, Department of Internal Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390, USA
    Biochem Biophys Res Commun 277:20-6. 2000
  2. ncbi Evidence for translational repression of the SOCS-1 major open reading frame by an upstream open reading frame
    G Schluter
    Institute of Human Genetics, University of Gottingen, Heinrich Düker Weg 12, Gottingen, 37073, Germany
    Biochem Biophys Res Commun 268:255-61. 2000
  3. pmc MiR-19a targets suppressor of cytokine signaling 1 to modulate the progression of neuropathic pain
    Conghui Wang
    Department of Anesthesiology, The First Hospital of Xiangyang City Xiangyang 441000, Hubei Province, China
    Int J Clin Exp Pathol 8:10901-7. 2015
  4. pmc Transcellular delivery of vesicular SOCS proteins from macrophages to epithelial cells blunts inflammatory signaling
    Emilie Bourdonnay
    Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine and Department of Microbiology and Immunology, University of Michigan Medical School and Department of Environmental Health Sciences, School of Public Health University of Michigan, Ann Arbor, MI 48109
    J Exp Med 212:729-42. 2015
  5. doi Suppression of microRNA-155 attenuates neuropathic pain by regulating SOCS1 signalling pathway
    Yi Tan
    Department of Anesthesiology, Xiangya Hospital of Central South University, 87 Xiangya Road, Changsha, 410008, Hunan, People s Republic of China
    Neurochem Res 40:550-60. 2015
  6. pmc Suppressor of cytokine signaling 1 (SOCS1) mitigates anterior uveitis and confers protection against ocular HSV-1 infection
    Cheng Rong Yu
    Molecular Immunology Section, Laboratory of Immunology, National Eye Institute, National Institutes of Health, Building 10, Room 10N109A, 10 Center Drive, Bethesda, MD, 20892 1857, USA
    Inflammation 38:555-65. 2015
  7. pmc Elevated suppressor of cytokine signaling-1 (SOCS-1): a mechanism for dysregulated osteoclastogenesis in HIV transgenic rats
    Mark K Lafferty
    Division of Basic Science and Vaccine Research, Institute of Human Virology, University of Maryland School of Medicine, Baltimore, MD, 21201, USA Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD, 21201, USA
    Pathog Dis 71:81-9. 2014
  8. doi Effects of ischemic preconditioning on myocardium Caspase-3, SOCS-1, SOCS-3, TNF-α and IL-6 mRNA expression levels in myocardium IR rats
    Jiangwei Ma
    Department of Cardiology, Nanjing Drum Tower Hospital, Nanjing Medical University, Nanjing, 210008, China
    Mol Biol Rep 40:5741-8. 2013
  9. pmc Interferon-γ biphasically regulates angiotensinogen expression via a JAK-STAT pathway and suppressor of cytokine signaling 1 (SOCS1) in renal proximal tubular cells
    Ryousuke Satou
    Department of Physiology and Hypertension and Renal Center of Excellence, Tulane University Health Sciences Center, New Orleans, LA 70112 2699, USA
    FASEB J 26:1821-30. 2012
  10. doi Inhibition of microRNA let-7i depresses maturation and functional state of dendritic cells in response to lipopolysaccharide stimulation via targeting suppressor of cytokine signaling 1
    Maomao Zhang
    Key Laboratories of Education Ministry for Myocardial Ischemia Mechanism and Treatment, Harbin Medical University, Harbin, Heilongjiang Province 150081, China
    J Immunol 187:1674-83. 2011

Scientific Experts

  • Antonio Cittadini
  • Ryousuke Satou
  • Ly Q Hong-Brown
  • Martin G Friedrich
  • Mingqin Lu
  • Sheela Ramanathan
  • Gregor Schlüter
  • Hong Wang
  • A F Nicol
  • Mark K Lafferty
  • Kohjiro Ueki
  • Emilie Bourdonnay
  • Conghui Wang
  • Yi Tan
  • Cheng Rong Yu
  • Rui dan Zheng
  • Jiangwei Ma
  • Qin Ning
  • William Reid
  • Lihong Liao
  • Maomao Zhang
  • Jia Xu
  • Guadalupe Ortiz-Muñoz
  • G J Suo
  • Na Lv
  • Jie Qin
  • Anjana Yadav
  • Michael J Carper
  • Frederik J Steyn
  • Tetyana V Bagnyukova
  • Yu Liu
  • Andrea Worschech
  • C Zhu
  • Jane K Howard
  • Makoto Suzuki
  • Takayuki Miki
  • Julie Piessevaux
  • Kate D Sutherland
  • C Ronald Kahn
  • Tatsuya Kondo
  • Eun Jung Park
  • M Raccurt
  • Samir Ali
  • Min Wang
  • Daniel J Schneider
  • De Fen Shen
  • Loka Raghu Kumar Penke
  • Christine M Freeman
  • Jeffrey L Curtis
  • Charles E Egwuagu
  • Rashid M Mahdi
  • Zbigniew Zasłona
  • Kai Xiang
  • Yun Sang Lee
  • Joel A Swanson
  • Qulian Guo
  • Dong Li
  • Sally Przybranowski
  • Kozaburo Hayashi
  • Jun Yang
  • Peter Mancuso
  • Jennifer M Speth
  • Marc Peters-Golden
  • Qindong Tan
  • Qi Jiang
  • Chi Chao Chan
  • Alfredo Garzino-Demo
  • Dima Hammoud
  • George K Lewis
  • T Kisseleva
  • Joseph Bryant
  • Shigeru Sakuda
  • Odell Jones
  • M Neale Weitzmann
  • Lori Fantry
  • Cheng Bin Wang
  • Biao Xu
  • Jin Zhi Gao
  • Zengyong Qiao
  • Yan Qin Ying
  • Xiao Ping Luo
  • Juan Ye
  • Li Hong Liao
  • T S Johnson
  • R A Mooney
  • Yanqin Ying
  • Jinzhi Gao
  • Chengbin Wang
  • Xiaoping Luo
  • Li Yin

Detail Information

Publications48

  1. ncbi Leptin resistance of adipocytes in obesity: role of suppressors of cytokine signaling
    Z Wang
    Gifford Laboratories, Touchstone Center for Diabetes Research, Department of Internal Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390, USA
    Biochem Biophys Res Commun 277:20-6. 2000
    ....
  2. ncbi Evidence for translational repression of the SOCS-1 major open reading frame by an upstream open reading frame
    G Schluter
    Institute of Human Genetics, University of Gottingen, Heinrich Düker Weg 12, Gottingen, 37073, Germany
    Biochem Biophys Res Commun 268:255-61. 2000
    ....
  3. pmc MiR-19a targets suppressor of cytokine signaling 1 to modulate the progression of neuropathic pain
    Conghui Wang
    Department of Anesthesiology, The First Hospital of Xiangyang City Xiangyang 441000, Hubei Province, China
    Int J Clin Exp Pathol 8:10901-7. 2015
    ..We aimed to investigate whether miR-19a is associated with neuropathic pain and elucidate the underlying regulatory mechanism...
  4. pmc Transcellular delivery of vesicular SOCS proteins from macrophages to epithelial cells blunts inflammatory signaling
    Emilie Bourdonnay
    Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine and Department of Microbiology and Immunology, University of Michigan Medical School and Department of Environmental Health Sciences, School of Public Health University of Michigan, Ann Arbor, MI 48109
    J Exp Med 212:729-42. 2015
    ..Here we report that alveolar macrophages can secrete SOCS1 and -3 in exosomes and microparticles, respectively, for uptake by alveolar epithelial cells and subsequent ..
  5. doi Suppression of microRNA-155 attenuates neuropathic pain by regulating SOCS1 signalling pathway
    Yi Tan
    Department of Anesthesiology, Xiangya Hospital of Central South University, 87 Xiangya Road, Changsha, 410008, Hunan, People s Republic of China
    Neurochem Res 40:550-60. 2015
    ..that miR-155 directly bound with the 3'-untranslated region of the suppressor of cytokine signalling 1 (SOCS1)...
  6. pmc Suppressor of cytokine signaling 1 (SOCS1) mitigates anterior uveitis and confers protection against ocular HSV-1 infection
    Cheng Rong Yu
    Molecular Immunology Section, Laboratory of Immunology, National Eye Institute, National Institutes of Health, Building 10, Room 10N109A, 10 Center Drive, Bethesda, MD, 20892 1857, USA
    Inflammation 38:555-65. 2015
    ..Suppressors of cytokine signaling (SOCS) regulate intensity/duration of inflammatory responses. We have used SOCS1-deficient mice and retina-specific SOCS1 transgenic rats to investigate roles of SOCS1 in ocular herpes simplex ..
  7. pmc Elevated suppressor of cytokine signaling-1 (SOCS-1): a mechanism for dysregulated osteoclastogenesis in HIV transgenic rats
    Mark K Lafferty
    Division of Basic Science and Vaccine Research, Institute of Human Virology, University of Maryland School of Medicine, Baltimore, MD, 21201, USA Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD, 21201, USA
    Pathog Dis 71:81-9. 2014
    ..Understanding the molecular mechanisms of HIV-associated BMD changes has the potential to detect and treat bone metabolism disturbances early and improve the quality of life in patients. ..
  8. doi Effects of ischemic preconditioning on myocardium Caspase-3, SOCS-1, SOCS-3, TNF-α and IL-6 mRNA expression levels in myocardium IR rats
    Jiangwei Ma
    Department of Cardiology, Nanjing Drum Tower Hospital, Nanjing Medical University, Nanjing, 210008, China
    Mol Biol Rep 40:5741-8. 2013
    ..01) compared to IR model group. We conclude that IP is effective in the therapy of heart disease. These findings may have implications for the clinical development of preconditioning-based therapies for ischemic heart disease...
  9. pmc Interferon-γ biphasically regulates angiotensinogen expression via a JAK-STAT pathway and suppressor of cytokine signaling 1 (SOCS1) in renal proximal tubular cells
    Ryousuke Satou
    Department of Physiology and Hypertension and Renal Center of Excellence, Tulane University Health Sciences Center, New Orleans, LA 70112 2699, USA
    FASEB J 26:1821-30. 2012
    ..RPTCs were incubated with or without IFN-γ up to 48 h. AGT expression, STAT1 and STAT3 activities, and SOCS1 expression were evaluated...
  10. doi Inhibition of microRNA let-7i depresses maturation and functional state of dendritic cells in response to lipopolysaccharide stimulation via targeting suppressor of cytokine signaling 1
    Maomao Zhang
    Key Laboratories of Education Ministry for Myocardial Ischemia Mechanism and Treatment, Harbin Medical University, Harbin, Heilongjiang Province 150081, China
    J Immunol 187:1674-83. 2011
    ..Furthermore, Tregs with upregulated IL-10 underscored the tolerogenic effect of CD86(-) DCs. Suppressor of cytokine signaling 1 (SOCS1), a crucial mediator of DC maturation, was confirmed as a let-7i target gene by luciferase ..
  11. doi Suppressor of cytokine signaling 1 inhibits apoptosis of islet grafts through caspase 3 and apoptosis-inducing factor pathways in rats
    G J Suo
    Department of Surgery, Shanghai East Hospital, Tongji University, PR China
    Transplant Proc 42:2658-61. 2010
    ..Recently, we observed that overexpression of suppressor of cytokine signaling 1 (SOCS1) in islet grafts achieved an antiapoptotic effect, prolonging graft survival in a rat ..
  12. doi Regulation of cytokine-driven functional differentiation of CD8 T cells by suppressor of cytokine signaling 1 controls autoimmunity and preserves their proliferative capacity toward foreign antigens
    Sheela Ramanathan
    Immunology Division, Department of Pediatrics, Faculty of Medicine and Health Sciences, University of Sherbrooke, Sherbrooke, Canada
    J Immunol 185:357-66. 2010
    ..In this study, we examined whether CD8 T cells that accumulate in suppressor of cytokine signaling 1 (SOCS1)-deficient mice because of increased IL-15 signaling in vivo would respond to an autoantigen ..
  13. doi JANEX-1, a JAK3 inhibitor, protects pancreatic islets from cytokine toxicity through downregulation of NF-kappaB activation and the JAK/STAT pathway
    Na Lv
    Department of Biochemistry, Medical School and Diabetes Research Center, Chonbuk National University, Jeonju, Jeonbuk 561 756, Republic of Korea
    Exp Cell Res 315:2064-71. 2009
    ....
  14. doi Overexpression of suppressor of cytokine signaling 1 in islet grafts results in anti-apoptotic effects and prolongs graft survival
    Jie Qin
    Department of Anatomy, Histology and Embryology, Shanghai Medical College, Fudan University, 130 Dong an Road, Shanghai 200032, China
    Life Sci 84:810-6. 2009
    ..The aim of this study was to investigate whether overexpression of suppressor of cytokine signaling 1 (SOCS1) in islet grafts could achieve an anti-apoptotic effect and prolong graft survival.
  15. pmc Increased expression of suppressor of cytokine signaling-1 (SOCS-1): A mechanism for dysregulated T helper-1 responses in HIV-1 disease
    Anjana Yadav
    Institute of Human Virology of the University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Virology 385:126-33. 2009
    ..These results suggest a link between high levels of SOCS-1, defects in innate immunity and adaptive Th1 responses that may be reflected in the loss of Th1 immune competence observed with AIDS patients...
  16. pmc HIV-protease inhibitors induce expression of suppressor of cytokine signaling-1 in insulin-sensitive tissues and promote insulin resistance and type 2 diabetes mellitus
    Michael J Carper
    Washington University School of Medicine, Department of Internal Medicine, Division of Endocrinology, Metabolism, and Lipid Research, Southwest Tower, Room 846A, Campus Box 8127, 660 South Euclid Drive, St Louis, MO 63110, USA
    Am J Physiol Endocrinol Metab 294:E558-67. 2008
    ..Our findings therefore indicate that induction of the SOCS-1 signaling cascade by PIs could be an important contributing factor in the development of metabolic dysregulation associated with long-term exposures to HIV-PIs...
  17. ncbi Sequence analysis of the conserved protamine gene cluster shows that it contains a fourth expressed gene
    G Schluter
    Institut für Humangenetik der Universität, Gottingen, Germany
    Mol Reprod Dev 43:1-6. 1996
    ..5 kb. Finally, we demonstrate a high density of Alu elements, both full and fragmented copies, in the human PGC and discuss their localization with respect to evolutionary and functional aspects...
  18. pmc Suppressor of cytokine signaling 1 (SOCS-1) and SOCS-3 cause insulin resistance through inhibition of tyrosine phosphorylation of insulin receptor substrate proteins by discrete mechanisms
    Kohjiro Ueki
    Research Division, Joslin Diabetes Center, and Departmentof Medicine, Harvard Medical School, Boston, MA 02215, USA
    Mol Cell Biol 24:5434-46. 2004
    ..These data indicate that SOCS-1 and SOCS-3 act as negative regulators in insulin signaling and serve as one of the missing links between insulin resistance and cytokine signaling...
  19. ncbi SHP-2 regulates SOCS-1-mediated Janus kinase-2 ubiquitination/degradation downstream of the prolactin receptor
    Samir Ali
    Department of Medicine, Division of Hematology and Molecular Oncology Group, Royal Victoria Hospital, McGill University, Montreal, Quebec H3A 1A1, Canada
    J Biol Chem 278:52021-31. 2003
    ..Together our results provide a novel function for SHP-2 as a positive regulator of cytokine receptor signaling by regulating ubiquitination/degradation pathways...
  20. ncbi 15d-PGJ2 and rosiglitazone suppress Janus kinase-STAT inflammatory signaling through induction of suppressor of cytokine signaling 1 (SOCS1) and SOCS3 in glia
    Eun Jung Park
    Department of Pharmacology, Ajou University School of Medicine, Suwon, Korea 442 721
    J Biol Chem 278:14747-52. 2003
    ..Our data suggest that 15d-PGJ(2) and rosiglitazone suppress the initiation of JAK-STAT inflammatory signaling independently of PPAR-gamma, thus attenuating brain inflammation...
  21. ncbi Activation of signal transducer and activator transcription 3 and expression of suppressor of cytokine signal 1 during liver regeneration in rats
    Shigeru Sakuda
    Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, 2 2 Yamadaoka, Suita, 565 0871, Osaka, Japan
    J Hepatol 36:378-84. 2002
    ..The aims of this study were to identify STAT3-activated cells and to clarify the expression of suppressor of cytokine signal (SOCS), a negative feedback molecule of STAT3, after PH...
  22. ncbi Suppressors of cytokine signaling-1 and -6 associate with and inhibit the insulin receptor. A potential mechanism for cytokine-mediated insulin resistance
    R A Mooney
    Department of Pathology, University of Rochester School of Medicine, Rochester, New York 14642, USA
    J Biol Chem 276:25889-93. 2001
    ..These results suggest that SOCS proteins may be inhibitors of IR signaling and could mediate cytokine-induced insulin resistance and contribute to the pathogenesis of type II diabetes...
  23. doi Effects of SOCS 1/3 gene silencing on the expression of C/EBPα and PPARγ during differentiation and maturation of rat preadipocytes
    Rui dan Zheng
    Department of Pediatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
    Pediatr Res 73:263-7. 2013
    ..Subjects with insulin resistance are often obese and have increased expressions of SOCS-1 and SOCS-3. We speculated that SOCS-1 and SOCS-3 may be involved in abnormal deposition of adipose tissues during insulin resistance...
  24. pmc SOCS1 gene transfer accelerates the transition to heart failure through the inhibition of the gp130/JAK/STAT pathway
    Antonio Cittadini
    Department of Clinical Medicine and Cardiovascular and Immunological Sciences, University Federico II, Via Sergio Pansini 5, 80131 Naples, Italy
    Cardiovasc Res 96:381-90. 2012
    ..To this aim, we investigated the effects of SOCS1 overexpression obtained by in vivo adeno-associated gene transfer using an aortopulmonary cross-clamping technique ..
  25. ncbi Functional cross-modulation between SOCS proteins can stimulate cytokine signaling
    Julie Piessevaux
    Flanders Interuniversity Institute for Biotechnology, Department of Medical Protein Research, Faculty of Medicine and Health Sciences, Ghent University, B 9000 Ghent, Belgium
    J Biol Chem 281:32953-66. 2006
    ..Our findings point to a unique regulatory role for SOCS2, SOCS6, and SOCS7 within the SOCS family and provide an explanation for the unexpected phenotypes observed in SOCS2 and SOCS6 transgenic mice...
  26. ncbi Differential expression of suppressors of cytokine signalling genes in response to nutrition and growth hormone in the septic rat
    T S Johnson
    Division of Clinical Sciences, Sheffield University, Northern General Hospital NHS Trust, Herries Road, Sheffield S5 7AU, UK
    J Endocrinol 169:409-15. 2001
    ..Here, we have investigated the impact of nutrition and GH treatment on GH receptor, SOCS1, SOCS-2, SOCS-3 and cytokine-inducible SH2-containing protein (CIS) hepatic mRNA expression in a rat model of ..
  27. ncbi Signaling through the JAK/STAT pathway, recent advances and future challenges
    T Kisseleva
    Department of Microbiology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Gene 285:1-24. 2002
    ..Similarly, the solution of the crystal structure of two STATs has and will continue to facilitate our understanding of how STATs function. This review will highlight these exciting developments in JAK/STAT signaling...
  28. ncbi Sepsis-induced muscle growth hormone resistance occurs independently of STAT5 phosphorylation
    Ly Q Hong-Brown
    Department of Cellular and Molecular Physiology, Hershey, Pennsylvania 17033, USA
    Am J Physiol Endocrinol Metab 285:E63-72. 2003
    ..In conclusion, sepsis produces GH resistance in both muscle and liver, with the locus of this impairment in muscle differing from that in liver and being independent of a defect in STAT5 phosphorylation...
  29. pmc Suppressor of cytokine signalling gene expression is elevated in breast carcinoma
    M Raccurt
    CNRS UMR 5123, Bât Raphaël Dubois, Universite Claude Bernard Lyon 1, 43 Blvd 11 Novembre 1918, F69622 Villeurbanne cedex, France
    Br J Cancer 89:524-32. 2003
    ....
  30. doi The influence of down-regulation of suppressor of cellular signaling proteins by RNAi on glucose transport of intrauterine growth retardation rats
    Lihong Liao
    Department of Pediatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
    Pediatr Res 69:497-503. 2011
    ..Down-regulation of SOCS-1 and SOCS-3 ameliorates the capacity of glucose transport and provides a potential gene therapy approach to managing metabolic syndrome...
  31. pmc Suppressors of cytokine signaling abrogate diabetic nephropathy
    Guadalupe Ortiz-Muñoz
    Renal and Vascular Research Laboratory, Fundacion Jimenez Diaz, Autonoma University, Madrid, Spain
    J Am Soc Nephrol 21:763-72. 2010
    ..In a rat model, inducing diabetes resulted in JAK/STAT activation and increased expression of SOCS1 and SOCS3...
  32. ncbi [Polymorphism and structural analysis of suppressor of cytokine signaling-1 of rat]
    Jia Xu
    Department of General Internal Medicine, First Affiliated Hospital of Sun Yat sen University, Guangzhou 510080, Guangdong, China
    Zhongguo Wei Zhong Bing Ji Jiu Yi Xue 22:259-62. 2010
    ..To identify the suppressor of cytokine signaling-1 (SOCS-1) of rat from the amplified gene with the help of bioinformatics to predict the deduced protein's structure and function in order to lay the foundation for further theoretical study...
  33. ncbi Methylation of apoptosis related genes in the pathogenesis and prognosis of prostate cancer
    Makoto Suzuki
    Hamon Center for Therapeutic Oncology Research University of Texas Southwestern Medical Center, Dallas TX, USA
    Cancer Lett 242:222-30. 2006
    ..were Reprimo, 54%; TMS1, 47%; DcR1, 45%; RRAD, 37%; DcR2, 37%; CRBP1, 34%; HPP1, 32%; RIZ1, 31%; DRM/Gremlin, 21%; SOCS1, 20%; DR4, 5%; DR5, 1%...
  34. pmc Central role of suppressors of cytokine signaling proteins in hepatic steatosis, insulin resistance, and the metabolic syndrome in the mouse
    Kohjiro Ueki
    Research Division, Joslin Diabetes Center and Department of Medicine, Harvard Medical School, Boston, MA 02215, USA
    Proc Natl Acad Sci U S A 101:10422-7. 2004
    ..Thus, SOCS proteins play an important role in pathogenesis of the metabolic syndrome by concordantly modulating insulin signaling and cytokine signaling...
  35. ncbi Differential hypermethylation of SOCS genes in ovarian and breast carcinomas
    Kate D Sutherland
    The Walter and Eliza Hall Institute of Medical Research and Bone Marrow Research Laboratories, Royal Melbourne Hospital, Parkville, VIC 3050, Australia
    Oncogene 23:7726-33. 2004
    ..We have investigated whether silencing or inactivation of SOCS genes occurs in ovarian and breast carcinomas. The SOCS1 and SOCS2 CpG islands were found to be hypermethylated in 23 and 14% of primary ovarian cancers, respectively, ..
  36. ncbi [Expression of suppressor of cytokine signaling in retina of experimental autoimmune uveoretinitis]
    Hong Wang
    Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China
    Zhonghua Yan Ke Za Zhi 44:876-82. 2008
    ..To investigate the expression and significance of suppressor of cytokine signaling (SOCS) mRNA and protein in retina of rats with experimental autoimmune uveoretinitis (EAU)...
  37. ncbi Prognostic relevance of methylation markers in patients with non-muscle invasive bladder carcinoma
    Martin G Friedrich
    Department of Urology, University of Southern California, 1441 Eastlake Avenue, Los Angeles, CA 90089 9176, USA
    Eur J Cancer 41:2769-78. 2005
    ..We identified one gene (TIMP-3) where methylation was associated with a more favourable outcome. Our data strongly support the usefulness of gene methylation as a prognostic marker in patients with non-muscle invasive bladder cancer...
  38. doi Donor bone-marrow suppressor of cytokine signaling-1-silenced dendritic cells prolong rat intestinal allograft survival
    C Zhu
    Department of General Surgery, Changzhou No 2 People s Hospital, Affiliated to Nanjing Medical University, Changzhou, Jiangsu, China
    Transplant Proc 40:3707-10. 2008
    ..The difference between untreated DCs group and the control group was not significant. In summary, SOCS-1 silenced DCs induced allogeneic T-cell hyporesponsiveness in vitro, promoting allograft survival in rat intestinal transplantation...
  39. ncbi [The study on the role of SOCS1 and SOCS3 in the livers of endotoxin tolerance rats]
    Ming Qin Lu
    Department of Infection Disease, First Affiliated Hospital, Wenzhou Medical College, Wenzhou 325000, China
    Zhonghua Yi Xue Za Zhi 88:2652-7. 2008
    To explore the mechanism of endotoxin tolerance(ETT) through observing the gene expression of SOCS1 and SOCS3 in the livers of ETT rats.
  40. ncbi Epigenetic downregulation of the suppressor of cytokine signaling 1 (Socs1) gene is associated with the STAT3 activation and development of hepatocellular carcinoma induced by methyl-deficiency in rats
    Tetyana V Bagnyukova
    Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, Arkansas 72079, USA
    Cell Cycle 7:3202-10. 2008
    ..activation of the STAT3 occurred only in fully developed HCC and was associated with downregulation of the Socs1 gene...
  41. ncbi Unique expression of suppressor of cytokine signaling 3 is essential for classical macrophage activation in rodents in vitro and in vivo
    Yu Liu
    Department of Medicine and Therapeutics, Institute of Medical Sciences, University of Aberdeen, Aberdeen, United Kingdom
    J Immunol 180:6270-8. 2008
    ..detectable SOCS proteins but those infiltrating inflamed glomeruli were rapidly polarized to express either SOCS1 (27 +/- 6%) or SOCS3 (54 +/- 12%) but rarely both (10 +/- 3%)...
  42. pmc Signatures associated with rejection or recurrence in HER-2/neu-positive mammary tumors
    Andrea Worschech
    Department of Microbiology and Immunology, Virginia Commonwealth University School of Medicine, Massey Cancer Center, Richmond, VA 23298, USA
    Cancer Res 68:2436-46. 2008
    ..These data provide a road map for the identification of novel biomarkers of immune responsiveness in clinical trials...
  43. doi Hormonal regulation of suppressors of cytokine signaling (SOCS) messenger ribonucleic acid in the arcuate nucleus during late pregnancy
    Frederik J Steyn
    Centre for Neuroendocrinology and Department of Anatomy and Structural Biology, University of Otago School of Medical Sciences, PO Box 913, Dunedin 9054, New Zealand
    Endocrinology 149:3206-14. 2008
    ....
  44. ncbi Alteration in erythropoietin-induced cardioprotective signaling by postinfarct ventricular remodeling
    Takayuki Miki
    Second Department of Internal Medicine, Sapporo Medical University School of Medicine, Chuo Ku, Japan
    J Pharmacol Exp Ther 317:68-75. 2006
    ..However, in the remodeled myocardium, lack of PI3K/Akt activation by the EPO receptor seems to be compensated by a mechanism upstream of the guanylyl cyclase-mitoK(ATP) channel pathway to achieve EPO-induced protection...
  45. ncbi [DNA methylation on urinalysis and as a prognostic marker in urothelial cancer of the bladder]
    M G Friedrich
    Klinik und Poliklinik fur Urologie, Universitat Hamburg, Universitatsklinikum Hamburg Eppendorf, Hamburg
    Urologe A 46:761-8. 2007
    ..We studied the versatility of DNA methylation for noninvasive diagnosis and as a prognostic marker for non-muscle-invasive bladder carcinoma...
  46. ncbi Attenuation of leptin and insulin signaling by SOCS proteins
    Jane K Howard
    Endocrine Unit, Imperial College, Hammersmith Hospital Campus, Du Cane Road, London W12 ONN, UK
    Trends Endocrinol Metab 17:365-71. 2006
    ..evidence suggests that SOCS3 appears to be of particular importance in the development of leptin resistance, whereas the ability to diminish insulin action has been described for several SOCS proteins (SOCS1, SOCS3, SOCS6 and SOCS7).
  47. ncbi In situ detection of SOCS and cytokine expression in the uterine cervix from HIV/HPV coinfected women
    A F Nicol
    Immunology Service of Evandro Chagas Clinical Research Institute, IPEC, FIOCRUZ, Avenue Brazil 4365 Manguinhos, Rio de Janeiro, CEP 21045 900, Brazil
    Exp Mol Pathol 81:42-7. 2006
    ....