Slc39a8

Summary

Gene Symbol: Slc39a8
Description: solute carrier family 39 member 8
Alias: zinc transporter ZIP8, ZIP-8, solute carrier family 39 (metal ion transporter), member 8, solute carrier family 39 (zinc transporter), member 8, zrt- and Irt-like protein 8
Species: rat

Top Publications

  1. doi Cellular localization and developmental changes of Zip8, Zip14 and transferrin receptor 1 in the inner ear of rats
    Dalian Ding
    Department of Otolaryngology Head and Neck Surgery, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, China
    Biometals 27:731-44. 2014
  2. doi Cellular iron uptake, trafficking and metabolism: Key molecules and mechanisms and their roles in disease
    D J R Lane
    Department of Pathology and Bosch Institute, Molecular Pharmacology and Pathology Program, Blackburn Building, University of Sydney, Sydney, New South Wales 2006, Australia Electronic address
    Biochim Biophys Acta 1853:1130-44. 2015
  3. pmc Regulators of Iron Homeostasis: New Players in Metabolism, Cell Death, and Disease
    Alexander R Bogdan
    Department of Biological Sciences, North Carolina State University, Campus Box 7633, Raleigh, NC 27695 7633, USA
    Trends Biochem Sci 41:274-86. 2016
  4. doi Suppression of ZIP8 expression is a common feature of cadmium-resistant and manganese-resistant RBL-2H3 cells
    Hitomi Fujishiro
    Laboratory of Molecular Nutrition and Toxicology, Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Yamashiro cho, Tokushima 770 8514, Japan
    Metallomics 5:437-44. 2013
  5. pmc ZIP8 is an iron and zinc transporter whose cell-surface expression is up-regulated by cellular iron loading
    Chia Yu Wang
    Food Science and Human Nutrition Department, University of Florida, Gainesville, Florida 32611, USA
    J Biol Chem 287:34032-43. 2012
  6. doi High sensitivity of RBL-2H3 cells to cadmium and manganese: an implication of the role of ZIP8
    Hitomi Fujishiro
    Laboratory of Molecular Nutrition and Toxicology, Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Tokushima, Japan
    Metallomics 3:710-8. 2011

Scientific Experts

  • Darius J R Lane
  • Dalian Ding
  • Hitomi Fujishiro
  • Alexander R Bogdan
  • Chia Yu Wang
  • Seiichiro Himeno
  • Kazunori Hashimoto
  • Masaki Miyazawa
  • Yoshiaki Tsuji
  • Toshinao Ohashi
  • Miki Takuma
  • Bryan Mackenzie
  • Mitchell D Knutson
  • Supak Jenkitkasemwong
  • Brian K Sparkman
  • Stephanie Duarte
  • Ali Shawki
  • Miwako Doi
  • Shuichi Enomoto

Detail Information

Publications6

  1. doi Cellular localization and developmental changes of Zip8, Zip14 and transferrin receptor 1 in the inner ear of rats
    Dalian Ding
    Department of Otolaryngology Head and Neck Surgery, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, China
    Biometals 27:731-44. 2014
    ....
  2. doi Cellular iron uptake, trafficking and metabolism: Key molecules and mechanisms and their roles in disease
    D J R Lane
    Department of Pathology and Bosch Institute, Molecular Pharmacology and Pathology Program, Blackburn Building, University of Sydney, Sydney, New South Wales 2006, Australia Electronic address
    Biochim Biophys Acta 1853:1130-44. 2015
    ..g., Friedreich's ataxia. Increased knowledge of the molecules and their mechanisms of action in iron processing pathways (e.g., ISC biogenesis) will shape the investigation of iron metabolism in human health and disease. ..
  3. pmc Regulators of Iron Homeostasis: New Players in Metabolism, Cell Death, and Disease
    Alexander R Bogdan
    Department of Biological Sciences, North Carolina State University, Campus Box 7633, Raleigh, NC 27695 7633, USA
    Trends Biochem Sci 41:274-86. 2016
    ..We also discuss emerging roles of iron in apoptosis and a novel iron-dependent cell death pathway termed 'ferroptosis', the dysregulation of iron metabolism in human pathologies, and the use of iron chelators in cancer therapy. ..
  4. doi Suppression of ZIP8 expression is a common feature of cadmium-resistant and manganese-resistant RBL-2H3 cells
    Hitomi Fujishiro
    Laboratory of Molecular Nutrition and Toxicology, Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Yamashiro cho, Tokushima 770 8514, Japan
    Metallomics 5:437-44. 2013
    ..involved in the uptake of Cd(2+) and Mn(2+), the expression of ZIP8 (Zrt-, Irt-related protein 8), encoded by Slc39a8, showed a marked suppression in both RBL-Cdr and RBL-Mnr cells...
  5. pmc ZIP8 is an iron and zinc transporter whose cell-surface expression is up-regulated by cellular iron loading
    Chia Yu Wang
    Food Science and Human Nutrition Department, University of Florida, Gainesville, Florida 32611, USA
    J Biol Chem 287:34032-43. 2012
    ZIP8 (SLC39A8) belongs to the ZIP family of metal-ion transporters. Among the ZIP proteins, ZIP8 is most closely related to ZIP14, which can transport iron, zinc, manganese, and cadmium...
  6. doi High sensitivity of RBL-2H3 cells to cadmium and manganese: an implication of the role of ZIP8
    Hitomi Fujishiro
    Laboratory of Molecular Nutrition and Toxicology, Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Tokushima, Japan
    Metallomics 3:710-8. 2011
    ..Thus, RBL-2H3 cells may serve as a good model for clarifying the mechanisms of Cd and Mn transport via ZIP8...