Slc11a2

Summary

Gene Symbol: Slc11a2
Description: solute carrier family 11 member 2
Alias: Dmt1, Nramp2, natural resistance-associated macrophage protein 2, DMT-1, NRAMP 2, Solute carrier family 11 member 2 (natural resistance-associated macrophage protein 2), divalent cation transporter 1, divalent metal transporter 1, solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2, solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2
Species: rat

Top Publications

  1. ncbi Cloning and characterization of a mammalian proton-coupled metal-ion transporter
    H Gunshin
    Renal Division, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 388:482-8. 1997
  2. ncbi Microcytic anaemia mice have a mutation in Nramp2, a candidate iron transporter gene
    M D Fleming
    Division of Hematology Oncology, Children s Hospital, Boston, Massachusetts, USA
    Nat Genet 16:383-6. 1997
  3. pmc Role of iron in the pathogenesis of cysteamine-induced duodenal ulceration in rats
    Tetyana Khomenko
    Diagnostic and Molecular Medicine Health Care Group, VA Medical Ctr, 5901 East 7St, Long Beach, CA 90822 5201, USA
    Am J Physiol Gastrointest Liver Physiol 296:G1277-86. 2009
  4. pmc Changes of ferrous iron and its transporters after intracerebral hemorrhage in rats
    Gaiqing Wang
    Department of Neurology, The Second Hospital, Shanxi Medical University 382 Wuyi Avenue, Taiyuan 030001, Shanxi, China
    Int J Clin Exp Pathol 8:10671-9. 2015
  5. doi Increased hippocampal expression of the divalent metal transporter 1 (DMT1) mRNA variants 1B and +IRE and DMT1 protein after NMDA-receptor stimulation or spatial memory training
    Paola Haeger
    Centro FONDAP de Estudios Moleculares de la Célula, Universidad de Chile, Independencia 1027, Santiago, Chile
    Neurotox Res 17:238-47. 2010
  6. pmc ZIP14 and DMT1 in the liver, pancreas, and heart are differentially regulated by iron deficiency and overload: implications for tissue iron uptake in iron-related disorders
    Hyeyoung Nam
    Food Science and Human Nutrition Department, University of Florida, Gainesville, FL, USA
    Haematologica 98:1049-57. 2013
  7. doi DMT1 as a candidate for non-transferrin-bound iron uptake in the peripheral nervous system
    Rocio Martínez Vivot
    Instituto de Química y Fisicoquímica Biológica IQUIFIB, UBA CONICET, Departamento de Quimica Biologica, Facultad de Farmacia y Bioquimica, Universidad de Buenos Aires, Junin 956 Buenos Aires C1113AAD, Argentina
    Biofactors 39:476-84. 2013
  8. doi Inflammation alters the expression of DMT1, FPN1 and hepcidin, and it causes iron accumulation in central nervous system cells
    Pamela Urrutia
    Department of Biology, Faculty of Sciences, Universidad de Chile and Research Ring on Oxidative Stress in the Nervous System, Santiago, Chile
    J Neurochem 126:541-9. 2013
  9. doi Goat milk consumption modulates liver divalent metal transporter 1 (DMT1) expression and serum hepcidin during Fe repletion in Fe-deficiency anemia
    J Díaz-Castro
    Department of Physiology, and
    J Dairy Sci 97:147-54. 2014
  10. doi Evidence for mitochondrial localization of divalent metal transporter 1 (DMT1)
    Natascha A Wolff
    1Department of Physiology and Pathophysiology and ZBAF, University of Witten Herdecke, Stockumer Strasse 12, D 58453 Witten, Germany F T
    FASEB J 28:2134-45. 2014

Scientific Experts

  • Frank Thevenod
  • Darius J R Lane
  • Dalian Ding
  • S Lortz
  • Helene Blasco
  • T Moos
  • Andrew Ghio
  • M T Nunez
  • P S Oates
  • C Beaumont
  • Hong Jiang
  • Ning Song
  • Fang Du
  • Wei Na Kong
  • Natascha A Wolff
  • Wei Zheng
  • Zhong Ming Qian
  • Craig P Smith
  • Xueqian Wang
  • Ya Ke
  • Khristy Thompson
  • Marouan Abouhamed
  • Gang Zheng
  • Junxia Xie
  • Shuzhen Zhang
  • Michael D Garrick
  • Lin Zhao
  • Xiang Lin Duan
  • Yan Zhong Chang
  • Jun Wang
  • Ramon M Molina
  • Joseph D Brain
  • Marianne Wessling-Resnick
  • Lan Xiong
  • Laura M Garrick
  • Wei lin Zhang
  • Rui Chen Shu
  • Goichi Beck
  • Renata Marciano
  • Gaiqing Wang
  • Rocío Martinez-Vivot
  • J Díaz-Castro
  • Vanina Usach
  • Hyeyoung Nam
  • Carrie E Thomas
  • Rocio Martínez Vivot
  • Pamela Urrutia
  • Andrew D Monnot
  • Jay A Cadieux
  • Wing Ho Yung
  • Shu E Zhao
  • Qing He
  • Lei Yang
  • Hélène Catoire
  • Jonghan Kim
  • Miguel Arredondo
  • Funmei Yang
  • Paola Haeger
  • Carole J Ferguson
  • Mark Wareing
  • Chengwu Gu
  • Guy A Rouleau
  • Gustavo Turecki
  • Tetyana Khomenko
  • Claudia Gaspar
  • Julio Salazar
  • Hanaâ Berradi
  • Thomas Donaghey
  • Stephanie J Garcia
  • Vijole Dzikaite
  • Bryan Mackenzie
  • Prasad N Paradkar
  • Wei Liu
  • M D Fleming
  • Martha P Mims
  • Kathleen P Griffin
  • Martin Knopfel
  • Hongyan Li
  • Janelle S Crossgrove
  • Weng In Leong
  • Daniela Riccardi
  • Roger Green
  • Mathieu Delannoy
  • Raymond F T McMahon
  • Marcia Simovich
  • Alan G Cox
  • Hai Yun Wang
  • Li Wang
  • Kousuke Baba
  • Jay N Umbreit

Detail Information

Publications68

  1. ncbi Cloning and characterization of a mammalian proton-coupled metal-ion transporter
    H Gunshin
    Renal Division, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 388:482-8. 1997
    ..DCT1 is a member of the 'natural-resistance-associated macrophage protein' (Nramp) family and thus its properties provide insight into how these proteins confer resistance to pathogens...
  2. ncbi Microcytic anaemia mice have a mutation in Nramp2, a candidate iron transporter gene
    M D Fleming
    Division of Hematology Oncology, Children s Hospital, Boston, Massachusetts, USA
    Nat Genet 16:383-6. 1997
    ..of a strong candidate gene for mk, and suggest that the phenotype is a consequence of a missense mutation in Nramp2 (ref. 5), a previously identified gene of unknown function...
  3. pmc Role of iron in the pathogenesis of cysteamine-induced duodenal ulceration in rats
    Tetyana Khomenko
    Diagnostic and Molecular Medicine Health Care Group, VA Medical Ctr, 5901 East 7St, Long Beach, CA 90822 5201, USA
    Am J Physiol Gastrointest Liver Physiol 296:G1277-86. 2009
    ..also enhanced activation of mucosal iron regulatory protein 1 and increased the expression of divalent metal transporter 1 mRNA and protein...
  4. pmc Changes of ferrous iron and its transporters after intracerebral hemorrhage in rats
    Gaiqing Wang
    Department of Neurology, The Second Hospital, Shanxi Medical University 382 Wuyi Avenue, Taiyuan 030001, Shanxi, China
    Int J Clin Exp Pathol 8:10671-9. 2015
    ..Divalent metal transporter1 (DMT1) is the important and well-known plasma membrane transport protein which was proved to be involved in the transport ..
  5. doi Increased hippocampal expression of the divalent metal transporter 1 (DMT1) mRNA variants 1B and +IRE and DMT1 protein after NMDA-receptor stimulation or spatial memory training
    Paola Haeger
    Centro FONDAP de Estudios Moleculares de la Célula, Universidad de Chile, Independencia 1027, Santiago, Chile
    Neurotox Res 17:238-47. 2010
    ..Neurons acquire iron through transferrin receptor-mediated endocytosis and via the divalent metal transporter 1 (DMT1)...
  6. pmc ZIP14 and DMT1 in the liver, pancreas, and heart are differentially regulated by iron deficiency and overload: implications for tissue iron uptake in iron-related disorders
    Hyeyoung Nam
    Food Science and Human Nutrition Department, University of Florida, Gainesville, FL, USA
    Haematologica 98:1049-57. 2013
    ..Our results provide insight into the potential contributions of these transporters to tissue iron uptake during iron deficiency and overload...
  7. doi DMT1 as a candidate for non-transferrin-bound iron uptake in the peripheral nervous system
    Rocio Martínez Vivot
    Instituto de Química y Fisicoquímica Biológica IQUIFIB, UBA CONICET, Departamento de Quimica Biologica, Facultad de Farmacia y Bioquimica, Universidad de Buenos Aires, Junin 956 Buenos Aires C1113AAD, Argentina
    Biofactors 39:476-84. 2013
    ..b>Divalent metal transporter 1(DMT1) has been widely described in literature as a key player in iron metabolism, but never before in ..
  8. doi Inflammation alters the expression of DMT1, FPN1 and hepcidin, and it causes iron accumulation in central nervous system cells
    Pamela Urrutia
    Department of Biology, Faculty of Sciences, Universidad de Chile and Research Ring on Oxidative Stress in the Nervous System, Santiago, Chile
    J Neurochem 126:541-9. 2013
    ..on total cell iron content and on the expression and abundance of the iron transporters divalent metal transporter 1 (DMT1) and Ferroportin 1 (FPN1) in neurons, astrocytes and microglia obtained from rat brain...
  9. doi Goat milk consumption modulates liver divalent metal transporter 1 (DMT1) expression and serum hepcidin during Fe repletion in Fe-deficiency anemia
    J Díaz-Castro
    Department of Physiology, and
    J Dairy Sci 97:147-54. 2014
    ..In spite of the crucial role of hepatocyte divalent metal transporter 1 (DMT1) and hepcidin in Fe metabolism, to date, no studies have directly tested the role of these ..
  10. doi Evidence for mitochondrial localization of divalent metal transporter 1 (DMT1)
    Natascha A Wolff
    1Department of Physiology and Pathophysiology and ZBAF, University of Witten Herdecke, Stockumer Strasse 12, D 58453 Witten, Germany F T
    FASEB J 28:2134-45. 2014
    ..Our results show that the divalent metal transporter 1 (DMT1) occurs in the OMM...
  11. doi Influence of cytokines on Dmt1 iron transporter and ferritin expression in insulin-secreting cells
    S Lortz
    Hannover Medical SchoolInstitute of Clinical Biochemistry, 30623 Hannover, Germany
    J Mol Endocrinol 52:301-10. 2014
    ..Therefore the expression of the different divalent metal transporter 1 (Dmt1) isoforms and ferritin (Ft) subunits, responsible for iron import and chelation, was analyzed ..
  12. doi Hepcidin Suppresses Brain Iron Accumulation by Downregulating Iron Transport Proteins in Iron-Overloaded Rats
    Fang Du
    Laboratory of Neuropharmacology, Fudan University School of Pharmacy, Shanghai, 201203, People s Republic of China
    Mol Neurobiol 52:101-14. 2015
    ..brain-blood barrier, iron uptake and release, and also the expression of transferrin receptor-1 (TfR1), divalent metal transporter 1 (DMT1), and ferroportin 1 (Fpn1) in cultured microvascular endothelial cells and neurons...
  13. doi Age-dependent expression of duodenal cytochrome b, divalent metal transporter 1, ferroportin 1, and hephaestin in the duodenum of rats
    Wei Na Kong
    Laboratory of Molecular Iron Metabolism, College of Life Science, The Key Laboratory of Animal Physiology, Biochemistry and Molecular Biology of Hebei Province, Hebei Normal University, Shijiazhuang, Hebei Province, China Bioreactor and Protein Drug Research and Development Center of Hebei Universities, Hebei Chemical and Pharmaceutical College, Shijiazhuang, Hebei Province, China
    J Gastroenterol Hepatol 30:513-20. 2015
    ..In the present study, we investigated the expression of iron transport proteins in the duodenum of Sprague-Dawley rats at five different age stages...
  14. doi Spinal peroxynitrite contributes to remifentanil-induced postoperative hyperalgesia via enhancement of divalent metal transporter 1 without iron-responsive element-mediated iron accumulation in rats
    Rui Chen Shu
    From the Department of Anesthesiology, Tianjin Medical University General Hospital, and Tianjin Research Institute of Anesthesiology, Tianjin, China
    Anesthesiology 122:908-20. 2015
    ..Iron accumulation mediated by divalent metal transporter 1 (DMT1) plays a key role in N-methyl-D-aspartate neurotoxicity...
  15. doi Cellular iron uptake, trafficking and metabolism: Key molecules and mechanisms and their roles in disease
    D J R Lane
    Department of Pathology and Bosch Institute, Molecular Pharmacology and Pathology Program, Blackburn Building, University of Sydney, Sydney, New South Wales 2006, Australia Electronic address
    Biochim Biophys Acta 1853:1130-44. 2015
    ..g., Friedreich's ataxia. Increased knowledge of the molecules and their mechanisms of action in iron processing pathways (e.g., ISC biogenesis) will shape the investigation of iron metabolism in human health and disease. ..
  16. doi Effects of prebiotic supplementation on the expression of proteins regulating iron absorption in anaemic growing rats
    Renata Marciano
    Department of Physiology, Physiology of Nutrition Discipline, Federal University of Sao Paulo, Rua Botucatu 862, 2nd Floor, 04023 060São Paulo, Brazil
    Br J Nutr 113:901-8. 2015
    ..HP inulin increased the expression of the divalent metal transporter 1 protein in the caecum by 162 % (P= 0·04), and the expression of duodenal cytochrome b reductase in the ..
  17. pmc Regulation of DMT1 on Bone Microstructure in Type 2 Diabetes
    Wei lin Zhang
    Department of Orthopedics, The First Hospital of China Medical University, Shenyang, Liaoning, China
    Int J Med Sci 12:441-9. 2015
    ..Therefore, the present study aimed to explore the function of DMT1 in the pathological process of diabetic osteoporosis...
  18. doi DMT1 iron uptake in the PNS: bridging the gap between injury and regeneration
    Rocío Martinez-Vivot
    Departamento de Quimica Biologica, Facultad de Farmacia y Bioquimica, Universidad de Buenos Aires, Instituto de Química y Fisicoquímica Biológica IQUIFIB, UBA CONICET, Buenos Aires, Argentina
    Metallomics 7:1381-9. 2015
    ..studies opened the door to further research on non-transferrin-bound iron uptake, which revealed the presence of DMT1 mRNA all along SC progeny, hinting at a constitutive role of DMT1 in ensuring the provision of iron in the PNS...
  19. pmc Deficiency of Calcium-Independent Phospholipase A2 Beta Induces Brain Iron Accumulation through Upregulation of Divalent Metal Transporter 1
    Goichi Beck
    Department of Neurology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    PLoS ONE 10:e0141629. 2015
    ..blotting was used to investigate the expression of molecules involved in iron homeostasis, including divalent metal transporter 1 (DMT1) and iron regulatory proteins (IRP1 and 2), in the brains of iPLA2β-knockout (KO) mice as well ..
  20. ncbi Regulatory effects of tumor necrosis factor-alpha and interleukin-6 on HAMP expression in iron loaded rat hepatocytes
    Vijole Dzikaite
    Department of Gastroenterology and Hepatology, Karolinska Institutet, Karolinska University Hospital Solna, 171 76 Stockholm, Sweden
    J Hepatol 44:544-51. 2006
    ..To study the effect of iron and proinflammatory cytokines on the expression of HAMP and other iron regulatory genes in primary rat hepatocytes...
  21. doi Increasing dietary protein acutely augments intestinal iron transporter expression and significantly increases iron absorption in rats
    Carrie E Thomas
    Department of Nutritional Sciences, University of Connecticut, Storrs, CT 06269, USA
    FASEB J 27:2476-83. 2013
    ..revealed that increasing dietary protein from 5 to 40% increased duodenal transcript expression of divalent metal transporter 1 (DMT1) 3.2-fold, duodenal cytochrome b (Dcytb) 1.8-fold, and transferrin receptor (TfR) 1.8-fold...
  22. pmc Relative contribution of CTR1 and DMT1 in copper transport by the blood-CSF barrier: implication in manganese-induced neurotoxicity
    Gang Zheng
    School of Health Sciences, Purdue University, West Lafayette, Indiana 47907, USA
    Toxicol Appl Pharmacol 260:285-93. 2012
    ..cerebrospinal fluid (CSF) is partially regulated by the Cu transporter-1 (CTR1) and divalent metal transporter-1 (DMT1) at the blood-CSF barrier (BCB) in the choroid plexus...
  23. pmc Mechanism of copper transport at the blood-cerebrospinal fluid barrier: influence of iron deficiency in an in vitro model
    Andrew D Monnot
    School of Health Sciences, Purdue University, 550 Stadium Mall Drive, CIVL1169, West Lafayette, IN 47907, USA
    Exp Biol Med (Maywood) 237:327-33. 2012
    ..The effect of FeD on cellular Cu retention and transporters Cu transporter-1 (Ctr1), divalent metal transporter 1 (DMT1), antioxidant protein-1 (ATOX1) and ATP7A was examined in choroidal epithelial Z310 cells...
  24. doi Synthesis and biological evaluation of substituted pyrazoles as blockers of divalent metal transporter 1 (DMT1)
    Jay A Cadieux
    Department of Medicinal Chemistry, Xenon Pharmaceuticals Inc, 3650 Gilmore Way, Burnaby, British Columbia, Canada V5G 4W8
    Bioorg Med Chem Lett 22:90-5. 2012
    Three distinct series of substituted pyrazole blockers of divalent metal transporter 1 (DMT1) were elaborated from the high-throughput screening pyrazolone hit 1...
  25. doi DMT1 polymorphism and risk of Parkinson's disease
    Qing He
    Department of Physiology, Shandong Provincial Key Laboratory of Pathogenesis and Prevention of Neurological Disorders and State Key Disciplines Physiology, Medical College of Qingdao University, Qingdao 266071, China
    Neurosci Lett 501:128-31. 2011
    ..b>Divalent metal transporter 1 (DMT1) is an endogenous transporter for ferrous iron, the levels of which are significantly increased ..
  26. doi Restless legs syndrome-associated MEIS1 risk variant influences iron homeostasis
    Hélène Catoire
    Centre of Excellence in Neuromics, CHUM Research Centre, University of Montreal, Montreal, Quebec, Canada
    Ann Neurol 70:170-5. 2011
    ..in Caenorhabditis elegans and that the RLS-associated haplotype leads to increased expression of ferritin and DMT1 in RLS brain tissues...
  27. doi Tanshinone IIA prevented brain iron dyshomeostasis in cerebral ischemic rats
    Lei Yang
    Department of Orthopedics, First Affiliated Hospital of Harbin Medical University, Harbin, China
    Cell Physiol Biochem 27:23-30. 2011
    ..The present study was aimed to determine whether Tanshinone IIA protects against cerebral ischemic injury via maintaining brain iron homeostasis...
  28. doi Association between divalent metal transport 1 encoding gene (SLC11A2) and disease duration in amyotrophic lateral sclerosis
    Helene Blasco
    UMR INSERM U930 CNRS 2448, Universite Francois Rabelais de Tours, Tours, France
    J Neurol Sci 303:124-7. 2011
    ..b>SLC11A2 gene encodes the divalent metal transport 1 (DMT1) mediating iron transport in cerebral endosomal compartments...
  29. doi Deficiency in the divalent metal transporter 1 increases bleomycin-induced lung injury
    Funmei Yang
    Department of Cellular and Structural Biology, The University of Texas Health Science Center, San Antonio, TX 78229, USA
    Biometals 23:657-67. 2010
    ..In lung cells, divalent metal transporter 1 (DMT1) can participate in metal transport resulting in control of an oxidative stress and tissue damage...
  30. doi Up-regulation of divalent metal transporter 1 in 6-hydroxydopamine intoxication is IRE/IRP dependent
    Hong Jiang
    Department of Physiology, Shandong Provincial Key Laboratory of Pathogenesis and Prevention of Neurological Disorders and State Key Disciplines Physiology, Medical College of Qingdao University, Qingdao 266071, China
    Cell Res 20:345-56. 2010
    ..Increased iron content of the substantia nigra (SN) has been found in PD patients, and divalent metal transporter 1 (DMT1) has been shown to be up-regulated in the SN of both MPTP-induced PD models and PD patients...
  31. pmc Divalent metal transporter 1 (DMT1) contributes to neurodegeneration in animal models of Parkinson's disease
    Julio Salazar
    Institut National de la Sante et de la Recherche Medicale, Neurologie et Thérapeutique Expérimentale, Unité Mixte de Recherche S679, 47 Boulevard de l Hopital, 75013 Paris, France
    Proc Natl Acad Sci U S A 105:18578-83. 2008
    ..Here, we describe an increase in the expression of an isoform of the divalent metal transporter 1 (DMT1/Nramp2/Slc11a2) in the SN of PD patients...
  32. ncbi Iron deficient and manganese supplemented diets alter metals and transporters in the developing rat brain
    Stephanie J Garcia
    Department of Physiology and Pharmacology, Wake Forest University Health Sciences, Winston Salem, North Carolina 27157, USA
    Toxicol Sci 95:205-14. 2007
    ..The results of this study confirm that there is homeostatic relationship among several essential metals in the brain and not simply between Fe and Mn...
  33. ncbi Divalent metal transporter 1 up-regulation is involved in the 6-hydroxydopamine-induced ferrous iron influx
    Ning Song
    Department of Physiology, Medical College of Qingdao University, Qingdao, China
    J Neurosci Res 85:3118-26. 2007
    ..We suppose, based on our previous studies, that the newly discovered iron transporter divalent metal transporter 1 (DMT1) might be involved in this SN iron accumulation process...
  34. ncbi Molecular genetic studies of DMT1 on 12q in French-Canadian restless legs syndrome patients and families
    Lan Xiong
    Laboratoire d étude des maladies du cerveau, Centre de Recherche du CHUM, Hopital Notre Dame, Universite de Montreal, 1560 rue Sherbrooke Est, Montreal, Quebec, Canada
    Am J Med Genet B Neuropsychiatr Genet 144:911-7. 2007
    ..Animal models with mutation in (DMT1) divalent metal transporter 1 gene, an important brain iron transporter, demonstrate a similar iron deficiency profile as found in ..
  35. ncbi Iron handling and gene expression of the divalent metal transporter, DMT1, in the kidney of the anemic Belgrade (b) rat
    Carole J Ferguson
    School of Biological Sciences, University of Manchester, Manchester, United Kingdom
    Kidney Int 64:1755-64. 2003
    ..shown that the rat kidney reabsorbs metabolically significant amounts of iron and that it expresses the divalent metal transporter 1, DMT1...
  36. ncbi Transport of divalent transition-metal ions is lost in small-intestinal tissue of b/b Belgrade rats
    Martin Knopfel
    Department of Biochemistry, SUNY, Buffalo, New York 14214 3000, USA
    Biochemistry 44:3454-65. 2005
    ..of a divalent metal transporter/divalent cation transporter/solute carrier 11 group A member 2 or 3 (DMT1/DCT1/SLC11A2), a member of the natural-resistance-associated macrophage protein (Nramp) family...
  37. ncbi NMR structures and orientation of the fourth transmembrane domain of the rat divalent metal transporter (DMT1) with G185D mutation in SDS micelles
    Hongyan Li
    Department of Chemistry and Open Laboratory of Chemical Biology, The University of Hong Kong, Pokfulam Road, Hong Kong
    Biopolymers 77:173-83. 2005
    DMT1, also known as Nramp2, is an iron transporter, and belongs to the family of Nramp proteins...
  38. ncbi Divalent metal-ion transporter DMT1 mediates both H+ -coupled Fe2+ transport and uncoupled fluxes
    Bryan Mackenzie
    Membrane Biology Program and Renal Division, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, 02115, USA
    Pflugers Arch 451:544-58. 2006
    The H(+) -coupled divalent metal-ion transporter DMT1 serves as both the primary entry point for iron into the body (intestinal brush-border uptake) and the route by which transferrin-associated iron is mobilized from endosomes to cytosol ..
  39. ncbi Identification of a human mutation of DMT1 in a patient with microcytic anemia and iron overload
    Martha P Mims
    Department of Hematology Oncology, Baylor College of Medicine, One Baylor Plaza 802E, Houston, TX 77030, USA
    Blood 105:1337-42. 2005
    b>Divalent metal transporter 1 (DMT1) is a transmembrane protein crucial for duodenal iron absorption and erythroid iron transport...
  40. ncbi Differential expression of divalent metal transporter DMT1 (Slc11a2) in the spermatogenic epithelium of the developing and adult rat testis
    Kathleen P Griffin
    School of Biological Sciences, University of Manchester, United Kingdom
    Am J Physiol Cell Physiol 288:C176-84. 2005
    ..The divalent metal transporter DMT1 is a key modulator of transferrin- and non-transferrin-bound iron homeostasis...
  41. ncbi Manganese distribution across the blood-brain barrier III. The divalent metal transporter-1 is not the major mechanism mediating brain manganese uptake
    Janelle S Crossgrove
    Graduate Center for Toxicology, University of Kentucky Medical Center, Lexington, KY 40536 0305 USA
    Neurotoxicology 25:451-60. 2004
    ..Mn appears to distribute across the rat blood-brain barrier (BBB) into the brain by one or more carrier-mediated processes other than the DMT-1...
  42. ncbi The significance of the mutated divalent metal transporter (DMT1) on iron transport into the Belgrade rat brain
    Torben Moos
    Department of Medical Anatomy, University of Copenhagen, Copenhagen, Denmark
    J Neurochem 88:233-45. 2004
    Brain iron transport and distributional pattern of divalent metal transporter I (DMT1) were studied in homozygous Belgrade rats (b/b) which suffer from a mutation in the DMT1 gene...
  43. ncbi Nitric oxide transcriptionally down-regulates specific isoforms of divalent metal transporter (DMT1) via NF-kappaB
    Prasad N Paradkar
    Department of Pharmacology and Toxicology, School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, New York, USA
    J Neurochem 96:1768-77. 2006
    Studies were performed to examine the affect of nitric oxide (NO) on expression of the divalent metal transporter (DMT1) in undifferentiated P19 embryonic carcinoma cells...
  44. ncbi DMT1 and FPN1 expression during infancy: developmental regulation of iron absorption
    Weng In Leong
    Department of Nutrition, University of California, Davis, California 95616, USA
    Am J Physiol Gastrointest Liver Physiol 285:G1153-61. 2003
    Two iron transporters, divalent metal transporter1 (DMT1) and ferroportin1 (FPN1) have been identified; however, their role during infancy is unknown...
  45. ncbi Localization of the iron transport proteins Mobilferrin and DMT-1 in the duodenum: the surprising role of mucin
    Marcia Simovich
    University of South Alabama, Mobile, Alabama, USA
    Am J Hematol 74:32-45. 2003
    ..This explains many of the unique properties of the iron-binding proteins and suggests that it may be a more general model for the absorption of other nutrients...
  46. ncbi Altered dietary iron intake is a strong modulator of renal DMT1 expression
    Mark Wareing
    School of Biological Sciences, Stopford Building, University of Manchester, Oxford Road, Manchester M13 9PT, UK
    Am J Physiol Renal Physiol 285:F1050-9. 2003
    Divalent metal transporter1 (DMT1; also known as DCT1 or NRAMP2) is an important component of the cellular machinery responsible for dietary iron absorption in the duodenum...
  47. ncbi Post-transcriptional expression of DMT1 in the heart of rat
    Ya Ke
    Laboratory of Iron Metabolism, Department of Applied Biology and Chemical Technology, Hong Kong Polytechnic University, Kowloon, Hong Kong
    J Cell Physiol 196:124-30. 2003
    ..NTBI uptake by heart cells might be mediated by divalent metal transporter 1 (DMT1)...
  48. ncbi A light and electron microscopic study of divalent metal transporter-1 distribution in the rat hippocampus, after kainate-induced neuronal injury
    Xin Sheng Wang
    Department of Anatomy, National University of Singapore, 119260, Singapore
    Exp Neurol 177:193-201. 2002
    ..The observation that DMT-1 is present on astrocytic end feet in contact with blood vessels suggests that these cells may be involved in uptake of iron from endothelial cells...
  49. ncbi Cellular location of proteins related to iron absorption and transport
    Marcia J Simovich
    University of South Alabama, Mobile, Alabama, USA
    Am J Hematol 69:164-70. 2002
    ..This suggests that there may be intracellular roles for these proteins in addition to their serving to transit iron across the cell surface membrane...
  50. ncbi Cellular localization of divalent metal transporter DMT-1 in rat kidney
    C J Ferguson
    School of Biological Sciences, University of Manchester, Manchester M13 9PT, United Kingdom
    Am J Physiol Renal Physiol 280:F803-14. 2001
    ..J Physiol (Lond) 524: 581-586, 2000]. To test the possibility that the divalent metal transporter DMT1 (Gunshin H, Mackenzie B, Berger UV, Gunshin Y, Romero MF, Boron WF, Nussberger S, Gollan JL, and Hediger MA...
  51. pmc Nramp2 is mutated in the anemic Belgrade (b) rat: evidence of a role for Nramp2 in endosomal iron transport
    M D Fleming
    Division of Hematology Oncology, Children s Hospital, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 95:1148-53. 1998
    ..Recently, mk has been attributed to a missense mutation in the gene encoding the putative iron transporter protein Nramp2. To investigate the possibility that Nramp2 was also mutated in the b rat, we established linkage of the phenotype ..
  52. doi Iron supply determines apical/basolateral membrane distribution of intestinal iron transporters DMT1 and ferroportin 1
    Marco T Nunez
    Departamento de Biologia, Facultad de Ciencias, Universidad de Chile, Las Palmeras 3425, Santiago, Chile
    Am J Physiol Cell Physiol 298:C477-85. 2010
    Intestinal iron absorption comprises the coordinated activity of the influx transporter divalent metal transporter 1 (DMT1) and the efflux transporter ferroportin (FPN)...
  53. doi Up-regulation of divalent metal transporter 1 is involved in 1-methyl-4-phenylpyridinium (MPP(+))-induced apoptosis in MES23.5 cells
    Shuzhen Zhang
    Department of Physiology, Medical College of Qingdao University, China
    Neurobiol Aging 30:1466-76. 2009
    ..In the present study, we investigate the involvement of divalent metal transporter 1 (DMT1) that accounts for the ferrous iron transport in MPP(+)-treated MES23.5 cells...
  54. doi Renal anemia induced by chronic ingestion of depleted uranium in rats
    Hanaâ Berradi
    Institut de Radioprotection et de Surete Nucleaire, Direction de la RadioProtection de l Homme, Service de Radiobiologie et d Epidemiologie, F 92262 Fontenay aux Roses Cedex, France
    Toxicol Sci 103:397-408. 2008
    ..messenger RNA (mRNA) and protein levels of spleen iron recycling markers from RBC degradation (DMT1 [divalent metal transporter 1], iron regulated protein 1, HO1, HO2 [heme oxygenase 1 and 2], cluster of differentiation 36), increase ..
  55. pmc Intracellular localization and subsequent redistribution of metal transporters in a rat choroid plexus model following exposure to manganese or iron
    Xueqian Wang
    School of Health Sciences, Purdue University, West Lafayette, IN 47907, USA
    Toxicol Appl Pharmacol 230:167-74. 2008
    ..e., divalent metal transporter 1 (DMT1), metal transporter protein 1 (MTP1), and transferrin receptor (TfR), in the rat intact choroid ..
  56. pmc Efflux of iron from the cerebrospinal fluid to the blood at the blood-CSF barrier: effect of manganese exposure
    Xueqian Wang
    School of Health Sciences, Purdue University, West Lafayette, IN 47907, USA
    Exp Biol Med (Maywood) 233:1561-71. 2008
    ..the effect was inhibited when the cells were pre-incubated with the antibody against divalent metal transport 1 (DMT1)...
  57. doi Lead and cadmium synergistically enhance the expression of divalent metal transporter 1 protein in central nervous system of developing rats
    Chengwu Gu
    Analytical Cytology Laboratory, Shantou University Medical College, Shantou, People s Republic of China
    Neurochem Res 34:1150-6. 2009
    b>Divalent metal transporter 1 (DMT1) can transport a large range of ions, including toxic lead (Pb) and cadmium (Cd), across membranes...
  58. pmc L-DOPA neurotoxicity is mediated by up-regulation of DMT1-IRE expression
    Fang Du
    Department of Physiology, Faculty of Medicine, The Chinese University of Hong Kong, New Territories, Hong Kong
    PLoS ONE 4:e4593. 2009
    ..Based on recent findings, we speculated that the increased expression of divalent metal transporter 1 without iron-response element (DMT1-IRE) induced by L-DOPA might play a critical role in the ..
  59. ncbi Augmented internalisation of ferroportin to late endosomes impairs iron uptake by enterocyte-like IEC-6 cells
    Phillip S Oates
    Department of Physiology, School of Biomedical and Chemical Sciences, The University of Western Australia, 35 Stirling Highway, Crawley, WA 6009, Australia
    Pflugers Arch 450:317-25. 2005
    Absorption of iron occurs by duodenal enterocytes, involving uptake by the divalent metal transporter-1 (DMT1) and release by ferroportin...
  60. ncbi Divalent metal transporter-1 decreases metal-related injury in the lung
    Andrew J Ghio
    National Health and Environmental Effects Research Laboratory, Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Am J Physiol Lung Cell Mol Physiol 289:L460-7. 2005
    ..Based on the fate of iron in airway epithelial cells, we postulated that divalent metal transporter-1 (DMT1) participates in detoxification of metal associated with air pollution particles...
  61. ncbi Two new human DMT1 gene mutations in a patient with microcytic anemia, low ferritinemia, and liver iron overload
    Carole Beaumont
    INSERM U773, Centre de Recherche Biomedicale Bichat Beaujon CRB3, BP 416, 16 rue Henri Huchard, F 75018 Paris, France
    Blood 107:4168-70. 2006
    b>DMT1 mediates the pH-dependent uptake of Fe(2+) from the diet in duodenal enterocytes and in most other cells. It transfers iron from the endosomes to the cytosol following the uptake of the transferrin-transferrin receptor complex...
  62. ncbi Iron absorption by Belgrade rat pups during lactation
    Khristy Thompson
    Department of Genetics and Complex Diseases, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA
    Am J Physiol Gastrointest Liver Physiol 293:G640-4. 2007
    Divalent metal transporter-1 (DMT1) mediates dietary nonheme iron absorption. Belgrade (b) rats have defective iron metabolism due to a mutation in the DMT1 gene...
  63. ncbi Knockdown of endosomal/lysosomal divalent metal transporter 1 by RNA interference prevents cadmium-metallothionein-1 cytotoxicity in renal proximal tubule cells
    Marouan Abouhamed
    Department of Physiology and Pathophysiology, University of Witten Herdecke, D 58448 Witten, Germany
    Am J Physiol Renal Physiol 293:F705-12. 2007
    ..The proton-coupled divalent metal transporter DMT1 also transports Cd2+ and is expressed exclusively in endosomes/lysosomes in rat PT cells...
  64. pmc Influence of DMT1 and iron status on inflammatory responses in the lung
    Jonghan Kim
    Department of Genetics and Complex Diseases, Harvard School of Public Health, Boston, Massachusetts, USA
    Am J Physiol Lung Cell Mol Physiol 300:L659-65. 2011
    b>Divalent metal transporter 1 (DMT1) is the major iron transporter responsible for duodenal dietary iron absorption and is required for erythropoiesis...
  65. pmc Olfactory uptake of manganese requires DMT1 and is enhanced by anemia
    Khristy Thompson
    Department of Genetics and Complex Diseases, Harvard School of Public Health, 665 Huntington Ave, Boston, MA 02115, USA
    FASEB J 21:223-30. 2007
    ..Divalent metal transporter-1 (DMT1) is the major transporter responsible for intestinal iron absorption and its expression is regulated by body iron ..
  66. ncbi Brain capillary endothelial cells mediate iron transport into the brain by segregating iron from transferrin without the involvement of divalent metal transporter 1
    Torben Moos
    Department of Medical Anatomy, University of Copenhagen, Copenhagen, Denmark
    J Neurochem 98:1946-58. 2006
    ..distribution was observed between Belgrade b/b rats with a mutation in divalent metal transporter I (DMT1), and Belgrade +/b rats with regard to accumulation in vascular and postvascular compartments...
  67. doi Decreased DMT1 and increased ferroportin 1 expression is the mechanisms of reduced iron retention in macrophages by erythropoietin in rats
    Wei Na Kong
    Laboratory of Molecular Iron Metabolism, College of Life Science, Hebei Normal University, Shijiazhuang 050016, Hebei Province, PR China
    J Cell Biochem 104:629-41. 2008
    ..The expression of divalent metal transporter 1 (DMT1) and ferroportin 1 (FPN1) in peritoneal exudate macrophages was detected by RT-PCR and Western ..
  68. ncbi Divalent metal transporter 1 in the kidney proximal tubule is expressed in late endosomes/lysosomal membranes: implications for renal handling of protein-metal complexes
    Marouan Abouhamed
    Department of Physiology and Pathophysiology, Faculty of Medicine, Univ of Witten Herdecke, Witten, Germany
    Am J Physiol Renal Physiol 290:F1525-33. 2006
    The H+-coupled polyligand transport protein divalent metal transporter 1 (DMT1) plays a key role in mammalian iron homeostasis. It has a widespread pattern of expression including tissues associated with iron acquisition and storage...