Sftpd

Summary

Gene Symbol: Sftpd
Description: surfactant protein D
Alias: SP-D, SPD, pulmonary surfactant-associated protein D, CP4, PSP-D, lung surfactant protein D, pulmonary surfactant protein D, surfactant associated protein D, surfactant, pulmonary-associated protein D
Species: rat

Top Publications

  1. ncbi Heterogeneous allele expression of pulmonary SP-D gene in rat large intestine and other tissues
    Zhenwu Lin
    Department of Cellular and Molecular Physiology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
    Physiol Genomics 11:235-43. 2002
  2. doi Patterns of neutrophil serine protease-dependent cleavage of surfactant protein D in inflammatory lung disease
    Jessica Cooley
    Immune Disease Institute, Harvard Medical School, Boston, MA 02115, USA
    J Leukoc Biol 83:946-55. 2008
  3. ncbi Multimerization of surfactant protein D, but not its collagen domain, is required for antiviral and opsonic activities related to influenza virus
    Mitchell White
    Department of Medicine, Boston University School of Medicine, Boston, MA 02118, USA
    J Immunol 181:7936-43. 2008
  4. doi Serum levels of surfactant protein D predict the anti-tumor activity of gefitinib in patients with advanced non-small cell lung cancer
    Hiroyuki Yamaguchi
    Second Department of Internal Medicine, Nagasaki University School of Medicine, 1 7 1 Sakamoto, Nagasaki 852 8501, Japan
    Cancer Chemother Pharmacol 67:331-8. 2011
  5. pmc S-nitrosylation of surfactant protein-D controls inflammatory function
    Chang Jiang Guo
    Department of Pharmacology and Toxicology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, New Jersey, USA
    PLoS Biol 6:e266. 2008
  6. ncbi Surfactant protein D increases phagocytosis and aggregation of pollen-allergen starch granules
    Veit J Erpenbeck
    Fraunhofer Institute of Toxicology and Experimental Medicine, Nikolai Fuchs Str 1a, 30625 Hannover, Germany
    Am J Physiol Lung Cell Mol Physiol 288:L692-8. 2005
  7. pmc Allergen particle binding by human primary bronchial epithelial cells is modulated by surfactant protein D
    Carsten Schleh
    Fraunhofer Institute for Toxicology and Experimental Medicine, Hannover, Germany
    Respir Res 11:83. 2010
  8. ncbi Pulmonary collectins enhance phagocytosis of Mycobacterium avium through increased activity of mannose receptor
    Kazumi Kudo
    Department of Biochemistry, Sapporo Medical University School of Medicine, South 1 West 17, Chuo Ku, Sapporo 060 8556, Japan
    J Immunol 172:7592-602. 2004
  9. ncbi Respiratory distress after intratracheal bleomycin: selective deficiency of surfactant proteins B and C
    R C Savani
    Division of Neonatology, Department of Pediatrics, The Children s Hospital of Philadelphia and University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 4399, USA
    Am J Physiol Lung Cell Mol Physiol 281:L685-96. 2001
  10. ncbi Aspergillus fumigatus-induced allergic airway inflammation alters surfactant homeostasis and lung function in BALB/c mice
    A Haczku
    Pulmonary, Allergy and Critical Care Division, Department of Medicine, University of Pennsylvania School of Medicine, 421 Curie Blvd, Philadelphia, PA 19104, USA
    Am J Respir Cell Mol Biol 25:45-50. 2001

Scientific Experts

Detail Information

Publications79

  1. ncbi Heterogeneous allele expression of pulmonary SP-D gene in rat large intestine and other tissues
    Zhenwu Lin
    Department of Cellular and Molecular Physiology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
    Physiol Genomics 11:235-43. 2002
    ..The parent-of-origin does not play a role in SP-D allele-specific expression. However, acquired epigenetic factors, family background, or other factors may contribute to the overall pattern of expression...
  2. doi Patterns of neutrophil serine protease-dependent cleavage of surfactant protein D in inflammatory lung disease
    Jessica Cooley
    Immune Disease Institute, Harvard Medical School, Boston, MA 02115, USA
    J Leukoc Biol 83:946-55. 2008
    ..The findings support a pre-eminent role for neutrophil elastase as the critical protease responsible for SP-D depletion in inflammatory lung disease...
  3. ncbi Multimerization of surfactant protein D, but not its collagen domain, is required for antiviral and opsonic activities related to influenza virus
    Mitchell White
    Department of Medicine, Boston University School of Medicine, Boston, MA 02118, USA
    J Immunol 181:7936-43. 2008
    ..However, the structure of the collagen domain significantly influences the anti-viral activity of multimerized forms of SP-D...
  4. doi Serum levels of surfactant protein D predict the anti-tumor activity of gefitinib in patients with advanced non-small cell lung cancer
    Hiroyuki Yamaguchi
    Second Department of Internal Medicine, Nagasaki University School of Medicine, 1 7 1 Sakamoto, Nagasaki 852 8501, Japan
    Cancer Chemother Pharmacol 67:331-8. 2011
    ..In this study, we evaluated prospectively whether surfactant protein-A (SP-A) and -D (SP-D) may be new conventional predictors of the efficacy of gefitinib treatment...
  5. pmc S-nitrosylation of surfactant protein-D controls inflammatory function
    Chang Jiang Guo
    Department of Pharmacology and Toxicology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, New Jersey, USA
    PLoS Biol 6:e266. 2008
    ..This represents new insight into both the regulation of protein function by S-nitrosylation and NO's role in innate immunity...
  6. ncbi Surfactant protein D increases phagocytosis and aggregation of pollen-allergen starch granules
    Veit J Erpenbeck
    Fraunhofer Institute of Toxicology and Experimental Medicine, Nikolai Fuchs Str 1a, 30625 Hannover, Germany
    Am J Physiol Lung Cell Mol Physiol 288:L692-8. 2005
    ..The modulation of allergen phagocytosis by SP-D might play an important role in allergen clearance from the lung and thereby modulate the allergic inflammation of asthma...
  7. pmc Allergen particle binding by human primary bronchial epithelial cells is modulated by surfactant protein D
    Carsten Schleh
    Fraunhofer Institute for Toxicology and Experimental Medicine, Hannover, Germany
    Respir Res 11:83. 2010
    ..In the present study, we investigated the uptake of SPP in human primary epithelial cells and the potential modulation by SP-D. The patho-physiological consequence was evaluated by measurement of pro-inflammatory mediators...
  8. ncbi Pulmonary collectins enhance phagocytosis of Mycobacterium avium through increased activity of mannose receptor
    Kazumi Kudo
    Department of Biochemistry, Sapporo Medical University School of Medicine, South 1 West 17, Chuo Ku, Sapporo 060 8556, Japan
    J Immunol 172:7592-602. 2004
    ..These results provide compelling evidence that SP-A and SP-D enhance mannose receptor-mediated phagocytosis of M. avium by macrophages...
  9. ncbi Respiratory distress after intratracheal bleomycin: selective deficiency of surfactant proteins B and C
    R C Savani
    Division of Neonatology, Department of Pediatrics, The Children s Hospital of Philadelphia and University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 4399, USA
    Am J Physiol Lung Cell Mol Physiol 281:L685-96. 2001
    ..We conclude that respiratory distress after bleomycin in rats results from surfactant dysfunction in part secondary to selective downregulation of SP-B and SP-C...
  10. ncbi Aspergillus fumigatus-induced allergic airway inflammation alters surfactant homeostasis and lung function in BALB/c mice
    A Haczku
    Pulmonary, Allergy and Critical Care Division, Department of Medicine, University of Pennsylvania School of Medicine, 421 Curie Blvd, Philadelphia, PA 19104, USA
    Am J Respir Cell Mol Biol 25:45-50. 2001
    ..These changes may contribute significantly to the pathophysiology of Af-induced allergic airway hyperresponsiveness...
  11. ncbi Surfactant protein levels in bronchoalveolar lavage after segmental allergen challenge in patients with asthma
    V J Erpenbeck
    Fraunhofer Institute of Toxicology and Experimental Medicine, Hannover, Germany
    Allergy 61:598-604. 2006
    ..Because surfactant proteins (SP) account for immunomodulatory functions as well as biophysical functions, we hypothesized that the allergic response in asthma might be accompanied by a dysregulation of SPs...
  12. ncbi Pneumocystis carinii pneumonia alters expression and distribution of lung collectins SP-A and SP-D
    E N Atochina
    Pulmonary and Critical Care Division, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia 19104 6061, USA
    J Lab Clin Med 137:429-39. 2001
    ..001). We conclude that PCP induces marked elevations in alveolar collectin levels because of increased expression and accumulation of SP-A and SP-D protein in SA surfactant...
  13. ncbi Recombinant rat surfactant-associated protein D inhibits human T lymphocyte proliferation and IL-2 production
    P J Borron
    Department of Medicine, The Lawson Research Institute, St Joseph s Health Centre, The University of Western Ontario, London, Canada
    J Immunol 161:4599-603. 1998
    ..We hypothesize that SP-D can dampen lymphocyte responses to exogenous stimuli and protect the lung against collateral immune-mediated damage...
  14. doi Novel strategy to identify genetic risk factors for COPD severity: a genetic isolate
    C C van Diemen
    Dept of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Eur Respir J 35:768-75. 2010
    ..MMP12, tissue inhibitor of metalloprotease-1 gene (TIMP1), surfactant protein A1 gene (SFTPA1 ), SFTPA2, SFTPB, SFTPD, glutathione S-transferase P1 gene (GSTP1), and haem oxygenase 1 gene ( HMOX1)...
  15. pmc Relationship between pulmonary surfactant protein and lipid peroxidation in lung injury due to paraquat intoxication in rats
    Hyo Wook Gil
    Department of Internal Medicine, Soonchunhyang University Medical College, Cheonan Hospital, Cheonan, Korea
    Korean J Intern Med 22:67-72. 2007
    ..The primary objective of this study was to evaluate the variations over time in levels of surfactant protein and lipid peroxidation (LPO) in lung tissue following free-radical-induced injury...
  16. doi The effects of fluticasone with or without salmeterol on systemic biomarkers of inflammation in chronic obstructive pulmonary disease
    Don D Sin
    Department of Medicine, Respiratory Division, University of British Columbia, Vancouver, Canada
    Am J Respir Crit Care Med 177:1207-14. 2008
    ..Small studies have suggested that inhaled corticosteroids can suppress systemic inflammation in chronic obstructive pulmonary disease (COPD)...
  17. doi Susceptibility of mice genetically deficient in SP-A or SP-D gene to invasive pulmonary aspergillosis
    Taruna Madan
    Institute of Genomics and Integrative Biology, Council for Scientific and Industrial Research, Delhi University Campus, Mall Road, Delhi 110007, India
    Mol Immunol 47:1923-30. 2010
    ..The results showed that SP-D gene deficient mice are more susceptible to IPA while SP-A gene deficient mice acquire resistance to IPA...
  18. ncbi Elevated expression of surfactant proteins in newborn rats during adaptation to hyperoxia
    C W White
    Department of Pediatrics, National Jewish Medical and Research Center, 1400 Jackson St, Denver, Colorado, USA
    Am J Respir Cell Mol Biol 25:51-9. 2001
    ..Taken together, these data indicate that specific surfactant proteins are upregulated at both the pretranslational and post-translational levels in distal lung epithelium during adaptation to hyperoxia in the newborn rat...
  19. ncbi Pulmonary-specific expression of SP-D corrects pulmonary lipid accumulation in SP-D gene-targeted mice
    J H Fisher
    Pulmonary Critical Care Medicine, Denver Health Medical Center and University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Am J Physiol Lung Cell Mol Physiol 278:L365-73. 2000
    ..Marked increases in biologically active tissue and alveolar SP-D do not alter lung morphology, macrophage abundance or structure, or surfactant accumulation...
  20. pmc Surfactant Protein D modulates allergen particle uptake and inflammatory response in a human epithelial airway model
    Carsten Schleh
    Fraunhofer Institute of Toxicology and Experimental Medicine, Nikolai Fuch Str 1, 30635 Hannover, Germany
    Respir Res 13:8. 2012
    ..The uptake of SPP as well as the secretion of pro-inflammatory cytokines was investigated...
  21. ncbi Regulation of surfactant protein D expression by glucocorticoids in vitro and in vivo
    R R Deterding
    Department of Pediatrics, National Jewish Center for Immunology and Respiratory Medicine, Denver, CO 80206
    Am J Respir Cell Mol Biol 10:30-7. 1994
    ..In vivo experiments were performed using maternal administration of dexamethasone (1 mg/kg) or an equal volume of saline on fetal days 15, 16, and 17 or on fetal day 17 with sacrifice on fetal day 18.(ABSTRACT TRUNCATED AT 250 WORDS)..
  22. pmc Surfactant protein D deficiency increases lung injury during endotoxemia
    Brooke A King
    Perinatal Institute, Section of Neonatology, Perinatal and Pulmonary Biology, Cincinnati Children s Hospital Medical Center, Ohio 45229 3039, USA
    Am J Respir Cell Mol Biol 44:709-15. 2011
    ..by intraperitoneal injection of LPS and direct lung injury by intratracheal injection of LPS in wild-type and Sftpd(-/-) mice to elucidate the role of SP-D during ALI/ARDS...
  23. pmc Prescreening based on the presence of CT-scan abnormalities and biomarkers (KL-6 and SP-D) may reduce severe radiation pneumonitis after stereotactic radiotherapy
    Hideomi Yamashita
    Department of Radiology, University of Tokyo Hospital, Hongo, Bunkyo ku, Tokyo, Japan
    Radiat Oncol 5:32. 2010
    ..To determine the risk factors of severe radiation pneumonitis (RP) after stereotactic body radiation therapy (SBRT) for primary or secondary lung tumors...
  24. doi Surfactant protein D modulates levels of IL-10 and TNF-α in intrauterine compartments during lipopolysaccharide-induced preterm birth
    Annamari Salminen
    Institute of Clinical Medicine, Department of Pediatrics, University of Oulu, FI 90014 Oulu, Finland
    Cytokine 60:423-30. 2012
    ..We conclude that SP-D in fetal and gestational tissues modulates the levels of intrauterine inflammatory mediators involved in preterm birth and may contribute to inflammatory processes related to spontaneous preterm labor...
  25. ncbi [Dynamic changes of surfactant protein-D and Clara cell protein expressions in lung tissue and bronchoalveolar lavage fluid of silica-treated rats]
    Ping Liu
    Department of Laboratory, Chongqing Medical University, Chongqing 400016, China
    Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 26:410-4. 2008
    ..To investigate the dynamic changes of surfactant protein-D (SP-D) and Clara cell protein (CC16) expressions in lung tissue and bronchoalveolar lavage fluid (BALF) of silica-treated rats...
  26. pmc The association between BMI and plasma cytokine levels in patients with acute lung injury
    Renee D Stapleton
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, University of Vermont College of Medicine, HSRF 222, Burlington, VT 05405, USA
    Chest 138:568-77. 2010
    ..We hypothesized that cytokine response might be attenuated in patients who are obese and critically ill or that obesity might modify the relationship between plasma cytokines and clinical outcomes in ALI...
  27. ncbi Sivelestat sodium hydrate improves septic acute lung injury by reducing alveolar dysfunction
    Shigeatsu Endo
    Department of Critical Care Medicine, Iwate Medical University, 19 1 Uchimaru, Morioka 020 8505, Japan
    Res Commun Mol Pathol Pharmacol 119:53-65. 2006
    ..Administration of sivelestat was found to reduce alveolar dysfunction and improve respiratory function, and it was suggested that early administration might be useful...
  28. ncbi Recognition of heptoses and the inner core of bacterial lipopolysaccharides by surfactant protein d
    Hua Wang
    Department Physiology and Biophysics, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Biochemistry 47:710-20. 2008
    ..7-O-Carbamoyl-l,d-heptose and d-glycero-alpha-d-manno-heptose were bound via ring hydroxyl groups. Interactions with the side chain of inner core heptoses provide a potential mechanism for the recognition of diverse types of LPS by SP-D...
  29. doi Children with absent surfactant protein D in bronchoalveolar lavage have more frequently pneumonia
    M Griese
    Children s Hospital, Grosshadern, University of Munich, Munich, Germany
    Pediatr Allergy Immunol 19:639-47. 2008
    ..In contrast, SP-D deficiency due to consumption or failure to up-regulate SP-D may be linked to pulmonary morbidity in children...
  30. pmc Polymorphisms in surfactant protein-D are associated with chronic obstructive pulmonary disease
    Marilyn G Foreman
    Pulmonary and Critical Care Medicine, Morehouse School of Medicine, Atlanta, GA 30310, USA
    Am J Respir Cell Mol Biol 44:316-22. 2011
    ..Surfactant protein-D (SFTPD) is immunomodulatory and essential to host defense...
  31. doi Prognostic value of serum surfactant protein D level prior to transplant for the development of bronchiolitis obliterans syndrome and idiopathic pneumonia syndrome following allogeneic hematopoietic stem cell transplantation
    T Nakane
    Clinical Hematology and Clinical Diagnostics, Graduate School of Medicine, Osaka City University, Abeno Ku, Osaka, Japan
    Bone Marrow Transplant 42:43-9. 2008
    ..08). Constitutive serum SP-D level before allo-HSCT may be a useful, noninvasive predictor for the development of BOS/IPS...
  32. pmc Surfactant protein D protects against acute hyperoxic lung injury
    Deepika Jain
    Pulmonary and Critical Care Division, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 4539, USA
    Am J Respir Crit Care Med 178:805-13. 2008
    ..Constitutive absence of SP-D in mice is associated with lung inflammation, alteration in surfactant lipid homeostasis, and increased oxidative-nitrative stress...
  33. doi Surfactant protein D and bronchial dysplasia in smokers at high risk of lung cancer
    Don D Sin
    St Paul s Hospital, 1081 Burrard Street, Vancouver, BC, Canada
    Chest 134:582-8. 2008
    ..Surfactant dysfunction has been implicated in both lung cancer and COPD. This study evaluated the relationship between surfactant protein D (SP-D) and the progression of bronchial dysplasia in heavy smokers...
  34. pmc Myeloperoxidase-dependent inactivation of surfactant protein D in vitro and in vivo
    Erika C Crouch
    Department of Pathology and Immunology, Washington University School of Medicine, Saint Louis, Missouri 63110, USA
    J Biol Chem 285:16757-70. 2010
    ..Thus, MPO-derived oxidants can lead to modifications of SP-D structure with associated alterations in its characteristic aggregating activity...
  35. doi Circulating surfactant protein D is decreased in systemic lupus erythematosus
    Silje Vermedal Hoegh
    Medical Biotechnology Center, Institute of Medical Biology, University of Southern Denmark, Odense, Denmark
    J Rheumatol 36:2449-53. 2009
    ..We investigated the possible association of the Met11Thr polymorphism with disease, since this polymorphism is an important determinant for serum level, oligomerization pattern, and function of SP-D...
  36. doi Clinical importance of bronchoalveolar lavage fluid and blood cytokines, surfactant protein D, and Kerbs von Lungren 6 antigen in idiopathic pulmonary alveolar proteinosis
    Fang Chi Lin
    Department of Internal Medicine, Yang Ming Branch, Taipei City Hospital, Taipei, Taiwan
    Mayo Clin Proc 83:1344-9. 2008
    To investigate the clinical importance of cytokines, surfactant protein D (SFTPD, formerly SP-D), and Kerbs von Lungren 6 antigen (KL-6) in bronchoalveolar lavage fluid (BALF) and blood in patients with idiopathic pulmonary alveolar ..
  37. doi Elevation of surfactant protein D, a pulmonary disease biomarker, in the sera of uveitis patients with sarcoidosis
    Nobuyoshi Kitaichi
    Department of Ophthalmology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Jpn J Ophthalmol 54:81-4. 2010
    ..In the present study, serum levels of SP-D were measured in patients with uveitis to ascertain whether SP-D is a clinically useful laboratory parameter to diagnose sarcoidosis...
  38. doi Surfactant protein D and KL-6 as serum biomarkers of interstitial lung disease in patients with scleroderma
    Faye N Hant
    Division of Rheumatology and Immunology, Department of Medicine, Medical University of South Carolina, 96 Jonathan Lucas Street, Suite 912, Charleston, SC 29425 6370, USA
    J Rheumatol 36:773-80. 2009
    ....
  39. pmc Monoclonal antibody-assisted structure-function analysis of the carbohydrate recognition domain of surfactant protein D
    Kevan L Hartshorn
    Department of Medicine, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Am J Physiol Lung Cell Mol Physiol 299:L384-92. 2010
    ....
  40. pmc Transmission of surfactant protein variants and haplotypes in children hospitalized with respiratory syncytial virus
    Neal J Thomas
    Department of Pediatrics, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
    Pediatr Res 66:70-3. 2009
    ..Further study is required to determine whether these variants can be used to target a high-risk patient population in clinical trials aimed at reducing either the symptoms of acute infection or long-term pulmonary sequelae...
  41. pmc Serum surfactant protein D during acute exacerbations of chronic obstructive pulmonary disease
    Tania Ahmed Shakoori
    Shaikh Zayed Medical Complex, Lahore, Pakistan
    Dis Markers 27:287-94. 2009
    ..However, it is not known whether serum levels change during exacerbations. We sought to determine whether serum SP-D levels are raised in COPD exacerbations...
  42. doi Eosinophilic inclusions in rat Clara cells and the effect of an inhaled corticosteroid
    Takahito Kambara
    Pathology, Safety Assessment UK, GlaxoSmithKline, Ware, UK
    Toxicol Pathol 37:315-23. 2009
    ....
  43. doi Association between single nucleotide polymorphisms of surfactant protein D and allergic rhinitis in Chinese patients
    Y Q Deng
    Department of Otolaryngology Head and Neck Surgery, Renmin Hospital of Wuhan University, Wuhan, China
    Tissue Antigens 73:546-52. 2009
    ..The present study aimed to investigate whether polymorphisms within the SFTPD gene (Met11Thr, Ala160Thr, and Ser270Thr) are associated with allergic rhinitis...
  44. pmc Rat respiratory coronavirus infection: replication in airway and alveolar epithelial cells and the innate immune response
    C Joel Funk
    National Jewish Health, 1400 Jackson Street, Denver, CO 80206, USA
    J Gen Virol 90:2956-64. 2009
    ....
  45. pmc Genetic variants of surfactant proteins A, B, C, and D in bronchopulmonary dysplasia
    J Pavlovic
    Department of Cellular and Molecular Physiology, PSU, Hershey, PA 17033, USA
    Dis Markers 22:277-91. 2006
    ..The data indicate that SP loci are linked to BPD. Studies in different study groups and/or of larger sample size are warranted to confirm these observations and delineate genetic background of BPD subgroups...
  46. ncbi KGF regulates pulmonary epithelial proliferation and surfactant protein gene expression in adult rat lung
    T Yano
    Department of Medicine, National Jewish Medical and Research Center, Denver, Colorado 80206, USA
    Am J Physiol Lung Cell Mol Physiol 279:L1146-58. 2000
    ..KGF increases the mRNA for the surfactant proteins per lung because of type II cell hyperplasia, but the mRNA per cell is slightly diminished as measured in isolated cells or estimated by in situ hybridization...
  47. ncbi Surfactant protein-D and surfactant inhibit endotoxin-induced pulmonary inflammation
    Machiko Ikegami
    Cincinnati Children s Hospital, Division of Pulmonary Biology, 3333 Burnet Ave, University of Cincinnati, OH 45229 3039, USA
    Chest 132:1447-54. 2007
    ..In this study, the effect of exogenous recombinant human SP-D (rhSP-D) on protection of the adult mouse lung from lipopolysaccharide (LPS)-induced and lipoteichoic acid (LTA)-induced injury was assessed...
  48. ncbi Surfactant proteins A and D enhance the phagocytosis of Chlamydia into THP-1 cells
    Rebecca E Oberley
    Department of Anatomy and Cell Biology, University of Iowa College of Medicine, Iowa City, IA 52242, USA
    Am J Physiol Lung Cell Mol Physiol 287:L296-306. 2004
    ..In addition, the chlamydial pathogens internalized in the presence of collectins are able to grow and replicate in the THP-1 cells after phagocytosis...
  49. pmc Attenuated allergic airway hyperresponsiveness in C57BL/6 mice is associated with enhanced surfactant protein (SP)-D production following allergic sensitization
    Elena N Atochina
    Pulmonary, Allergy and Critical Care Division, Department of Medicine, University of Pennsylvania, School of Medicine, Philadelphia, PA, USA
    Respir Res 4:15. 2003
    ..We hypothesized that an elevated SP-D production is associated with the impaired ability of C57BL/6 mice to develop allergic AHR...
  50. ncbi Surfactant protein D regulates airway function and allergic inflammation through modulation of macrophage function
    Katsuyuki Takeda
    Program in Cell Biology, Department of Pediatrics, National Jewish Medical and Research Center, Denver, Colorado, USA
    Am J Respir Crit Care Med 168:783-9. 2003
    ..These results indicate that SP-D can (negatively) regulate the development of AHR and airway inflammation after airway challenge of sensitized mice, at least in part, by modulating the function of alveolar macrophages...
  51. ncbi Macrophage-independent fungicidal action of the pulmonary collectins
    Francis X McCormack
    Veterans Affairs Medical Center, Cincinnati, Ohio 45220, USA
    J Biol Chem 278:36250-6. 2003
    ....
  52. pmc Surfactant protein D-mediated aggregation of Pneumocystis carinii impairs phagocytosis by alveolar macrophages
    Suk Joong Yong
    Thoracic Diseases Research Unit, Division of Pulmonary, Critical Care, and Internal Medicine, 8 24 Stabile Building, Mayo Clinic, Rochester, MN 55905, USA
    Infect Immun 71:1662-71. 2003
    ..Thus, SP-D-mediated aggregation of P. carinii may represent one means by which the organism avoids elimination by the host...
  53. ncbi Total extracellular surfactant is increased but abnormal in a rat model of gram-negative bacterial pneumonia
    Thomas A Russo
    Department of Medicine, State University of New York at Buffalo, Buffalo 14214, USA
    Am J Physiol Lung Cell Mol Physiol 283:L655-63. 2002
    ..In vitro surface cycling studies with calf lung surfactant extract suggested that bacterially derived factors may have contributed in part to the surfactant alterations seen in vivo...
  54. ncbi Reversibility of pulmonary abnormalities by conditional replacement of surfactant protein D (SP-D) in vivo
    Liqian Zhang
    Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
    J Biol Chem 277:38709-13. 2002
    ..However, once established, emphysema was not reversed by SP-D. SP-D-dependent processes regulating surfactant lipid homeostasis were disassociated from those mediating emphysema...
  55. ncbi Degradation of pulmonary surfactant protein D by Pseudomonas aeruginosa elastase abrogates innate immune function
    John F Alcorn
    Department of Cell Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 279:30871-9. 2004
    ..These data show that degradation of SP-D occurs in the BAL environment and that degradation eliminates many normal immune functions of SP-D...
  56. ncbi Serial changes in surfactant-associated proteins in lung and serum before and after onset of ARDS
    K E Greene
    Harborview Medical Center, Seattle, Washington, USA
    Am J Respir Crit Care Med 160:1843-50. 1999
    ..Strategies to increase these surfactant proteins in the lungs of patients with ARDS could be useful to modify the onset or the course of ARDS...
  57. ncbi Microfibril-associated protein 4 is present in lung washings and binds to the collagen region of lung surfactant protein D
    M Lausen
    Department of Immunology, Institute of Medical Biology, University of Southern Denmark, Odense University, DK 5000 Odense, Denmark
    J Biol Chem 274:32234-40. 1999
    ..b>Lung surfactant protein D (SP-D) was also purified from lung washings, and calcium-dependent binding was demonstrated between ..
  58. ncbi Surfactant protein levels in severe respiratory syncytial virus infection
    M H Kerr
    Department of Child Health, University of Glasgow, Royal Hospital for Sick Children, Glasgow, Scotland
    Am J Respir Crit Care Med 159:1115-8. 1999
    ..We conclude that alterations in surfactant protein concentrations are present in severe RSV infection and speculate that these may contribute to the abnormalities of lung function seen in this condition...
  59. ncbi [Clinical significance of serum surfactant proteins A and D in idiopathic interstitial pneumonia]
    Y Honda
    Third Department of Internal Medicine, Sapporo Medical University School of Medicine, Japan
    Nihon Kyobu Shikkan Gakkai Zasshi 34:181-5. 1996
    ..We conclude that measurement of SP-D and SP-A in sera can provide an easily identifiable and useful clinical marker for the diagnosis of IIP, and can be used to predict the disease activity of IIP...
  60. ncbi Adsorption of pulmonary surfactant protein D to phospholipid monolayers at the air-water interface
    S Taneva
    Department of Biochemistry, Memorial University of Newfoundland, St John s Newfoundland, Canada A1B 3X9
    Biochemistry 36:8173-9. 1997
    ....
  61. ncbi Purification and biochemical characterization of CP4 (SP-D), a collagenous surfactant-associated protein
    A Persson
    Department of Pathology, Jewish Hospital, Washington University Medical Center, St Louis, Missouri 63110
    Biochemistry 28:6361-7. 1989
    b>CP4 is a collagenous glycoprotein (43 kDa, reduced) synthesized by rat type II pulmonary epithelial cells in primary culture (Persson et al., 1988)...
  62. ncbi Characterization of the rat pulmonary surfactant protein A promoter
    T Lacaze-Masmonteil
    Unité de Recherches en Génétique et Pathologie Moléculaires, Institut National de la Santé et de la Recherche Médicale U 129, Paris France
    Eur J Biochem 206:613-23. 1992
    ..Some of these motifs, specifically protected in DNase 1 footprinting studies, could therefore be involved in the regulation of SP-A gene expression...
  63. ncbi Correction of pulmonary abnormalities in Sftpd-/- mice requires the collagenous domain of surfactant protein D
    Paul S Kingma
    Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
    J Biol Chem 281:24496-505. 2006
    ..was evaluated by expressing a SP-D collagen deletion mutant protein (rSftpdCDM) in wild type and SP-D null mice (Sftpd(-/-)). rSftpdCDM formed disulfide-linked trimers that further oligomerized into higher order structures...
  64. ncbi Sinonasal surfactant protein A1, A2, and D gene expression in cystic fibrosis: a preliminary report
    Bradford A Woodworth
    Department of Otorhinolaryngology Head and Neck Surgery, University of Pennsylvania Health System, Philadelphia, PA 19104, USA
    Otolaryngol Head Neck Surg 137:34-8. 2007
    ..To measure alterations in SPA1, A2, and D gene expression in various forms of inflammatory chronic rhinosinusitis (CRS)...
  65. ncbi Haplotypes of the surfactant protein genes A and D as susceptibility factors for the development of respiratory distress syndrome
    Neal J Thomas
    Department of Pediatrics, Penn State Children s Hospita, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
    Acta Paediatr 96:985-9. 2007
    ....
  66. ncbi High-dose vascular endothelial growth factor increases surfactant protein gene expressions in preterm rat lung
    Chung Ming Chen
    Department of Pediatrics, Taipei Medical University Hospital, Taipei, Taiwan
    Early Hum Dev 83:581-4. 2007
    ..To investigate the effects of intra-amniotic vascular endothelial growth factor (VEGF) treatment on surfactant pool sizes and surfactant protein (SP) gene expressions in fetal rat lung...
  67. ncbi Primary structure of rat pulmonary surfactant protein D. cDNA and deduced amino acid sequence
    H Shimizu
    Department of Medicine, National Jewish Center for Immunology and Respiratory Medicine, Denver, Colorado 80206
    J Biol Chem 267:1853-7. 1992
    ..Hybridization analysis demonstrates that rat SP-D is encoded by a 1.3-kilobase mRNA which is abundant in lung and highly enriched in alveolar type II cells. Extensive homology exists between rat SP-D and bovine conglutinin...
  68. ncbi SP-D-deficient mice are resistant to hyperoxia
    Deepika Jain
    Pulmonary and Critical Care Division, University of Pennsylvania School of Medicine, Room H410F, Hill Pavilion, 380 South University Ave, Philadelphia, PA 19107, USA
    Am J Physiol Lung Cell Mol Physiol 292:L861-71. 2007
    ....
  69. ncbi Pulmonary surfactant in patients with Pneumocystis pneumonia and acquired immunodeficiency syndrome
    Reinhold Schmidt
    University of Giessen Lung Center, Germany
    Crit Care Med 34:2370-6. 2006
    ..We analyzed pulmonary surfactant composition and function in bronchoalveolar lavage fluid (BALF) from ventilated and spontaneously breathing HIV-positive patients with PCP...
  70. ncbi Surfactant protein D inhibits early airway response in Aspergillus fumigatus-sensitized mice
    V J Erpenbeck
    Fraunhofer Institute of Toxicology and Experimental Medicine, Hannover, Germany
    Clin Exp Allergy 36:930-40. 2006
    ..However, little is known about the functional effect of SP-D on the early airway response upon allergen inhalation, which is an important feature of this disease...
  71. ncbi Pulmonary surfactant, lung function, and endobronchial inflammation in cystic fibrosis
    Matthias Griese
    Children s Hospital, University of Munich, Munich, Germany
    Am J Respir Crit Care Med 170:1000-5. 2004
    ....
  72. pmc Species differences in the carbohydrate binding preferences of surfactant protein D
    Erika C Crouch
    Dept of Pathology and Immunology, Campus Box 8118, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Am J Respir Cell Mol Biol 35:84-94. 2006
    ..Thus, ligand recognition by human SP-D involves a complex interplay between saccharide presentation, the valency of trimeric subunits, and species-specific residues that flank the primary carbohydrate binding site...
  73. pmc The role of surfactant protein D in the colonisation of the respiratory tract and onset of bacteraemia during pneumococcal pneumonia
    R Jounblat
    MRC Immunochemistry Unit, University of Oxford, South Parks Road, Oxford, OX1 3QU, UK
    Respir Res 6:126. 2005
    ..Our data provides evidence that SP-D has a significant role to play in the clearance of pneumococci during the early stages of infection in both pulmonary sites and blood...
  74. ncbi Distribution of surfactant proteins in type II pneumocytes of newborn, 14-day old, and adult rats: an immunoelectron microscopic and stereological study
    Andreas Schmiedl
    Centre of Anatomy, Hannover School of Medicine, Carl Neuberg Strasse 1, 30625, Hannover, Germany
    Histochem Cell Biol 124:465-76. 2005
    ..The postnatal compartment-specific distribution of SP-A, precursors of SP-C and SP-D does not change...
  75. ncbi Serum surfactant protein D is increased in acute and chronic inflammation in mice
    Masaki Fujita
    Research Institute for Diseases of the Chest, Graduate School of Medical Sciences, Kyushu University, Maidashi, Fukuoka, Japan
    Cytokine 31:25-33. 2005
    ..These data clarified profile of SP-A and SP-D in acute and chronic inflammation and indicated that serum SP-D can serve as a biomarker of lung inflammation in both acute and chronic lung injury in mice...
  76. doi Increased surfactant protein a and d expression in acute ovalbumin-induced allergic airway inflammation in brown norway rats
    A Schmiedl
    Institute of Functional and Applied Anatomy, Hannover Medical School, Hannover, Germany
    Int Arch Allergy Immunol 148:118-26. 2009
    ..The surfactant proteins SP-A and SP-D, components of the innate immune system, are involved in host defence...
  77. pmc Surfactant proteins A and D inhibit the growth of Gram-negative bacteria by increasing membrane permeability
    Huixing Wu
    Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Cincinnati, Cincinnati, Ohio, USA
    J Clin Invest 111:1589-602. 2003
    ....
  78. doi Critical role for cross-linking of trimeric lectin domains of surfactant protein D in antiviral activity against influenza A virus
    Tesfaldet Tecle
    Department of Medicine, Boston University School of Medicine, Boston, MA 02118, USA
    Biochem J 412:323-9. 2008
    ..These results show that antiviral activities of SP-D can be reproduced without the N-terminal and collagen domains and that cross-linking of NCRDs is essential for antiviral activity of SP-D with respect to IAV...
  79. ncbi Neither SP-A nor NH2-terminal domains of SP-A can substitute for SP-D in regulation of alveolar homeostasis
    Liqian Zhang
    Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, OH 45229, USA
    Am J Physiol Lung Cell Mol Physiol 291:L181-90. 2006
    ..and 3) rSftpd/a, consisting of NH(2)-terminal and collagenous domains of SP-D with neck domain and CRD of SP-A, in Sftpd(-/-) mice...

Research Grants20

  1. Regulation of Inflammation in Asthma by Fas Ligand
    Angela Haczku; Fiscal Year: 2009
    ..Finally, in order to help support the hypothesis that pro-apoptotic FasL activity characterized in human airway cells is truly physiologic, we will perform challenge studies in mice under FasL neutralizing conditions. ..
  2. Surfactant-Protein Innate Immunity in an Asthma Model
    Angela Haczku; Fiscal Year: 2008
    ..The potential opportunity to interfere with allergic sensitization by SP-D treatment bears high clinical significance. [unreadable] [unreadable]..
  3. STRUCTURE/FUNCTION OF SURFACTANT PROTEIN D
    Erika Crouch; Fiscal Year: 2006
    ..As in the past, secreted recombinant proteins with novel structural attributes will be characterized and utilized for collaborative studies of SP-D function. [unreadable] [unreadable]..
  4. ENHANCING COLLECTIN MEDIATED HOST DEFENSE
    Kevan Hartshorn; Fiscal Year: 2001
    ..These experiments should yield important insights into basic collection biology and demonstrate that enhancement of collectin-mediated pulmonary host defense can be achieved in vivo through rational alteration of wild type collectins. ..
  5. Lung epithelial cell survival signaling in ozone in cystic fibrosis and normals
    Carl White; Fiscal Year: 2009
    ..These studies will increase our understanding of lung oxidant injury and repair in CF and normals, and of normal defense mechanisms of airway epithelium. ..
  6. Surfactant protein variants in pediatric lung injury
    Neal Thomas; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  7. Lymphangioleiomyomatosis Research Conference 2006
    Francis McCormack; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  8. Hypoxia-inducible factors bronchopulmonary dysplasia-BPD
    Carl White; Fiscal Year: 2006
    ..Therapy at the level of HIF transcription factors to improve angiogenesis and alveolar development offers promise to prevent BPD. ..
  9. ROLE OF SURFACTANT PROTEIN D IN SURFACTANT HOMEOSTASIS
    Machiko Ikegami; Fiscal Year: 2006
    This proposal seeks to continue funding of HL-63329 to determine the mechanisms by which surfactant protein D (SPD) regulates surfactant phospholipid homeostasis...
  10. 2005 LAM Foundation Lymphangioleiomyomatosis Research
    Francis McCormack; Fiscal Year: 2005
    ..abstract_text> ..
  11. Lymphangioleimyomatosis Research Conference
    Francis McCormack; Fiscal Year: 2004
    ..abstract_text> ..
  12. BACTERIAL MODULATION OF LUNG INFLAMMATORY RESPONSE
    Thomas Russo; Fiscal Year: 2004
    ..g. hemolysin) and bacterially induced host response elements in directly mediating the pathogenesis of lung injury. ..
  13. Lymphangioleiomyomatosis Research Project
    Francis McCormack; Fiscal Year: 2003
    ..abstract_text> ..
  14. ROLE OF HEXOKINASE IN LUNG ADAPTATION TO OXIDANT STRESS
    Carl White; Fiscal Year: 2002
    ..Together, these approaches will define the role of HK in adaptation to hyperoxia. ..
  15. Novel Antioxidant Mechanisms of Surfactant Proteins
    Francis McCormack; Fiscal Year: 2006
    ..The results will provide important insights into the roles of the surfactant proteins in preventing oxidative lung disease and may be useful for the design of novel recombinant proteins and peptides of therapeutic value. ..
  16. The 2007 LAM Foundation Lymphangioleiomyomatosis International Research Conferenc
    Francis McCormack; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  17. Lymphangioleiomyomatosis Research Project
    Francis McCormack; Fiscal Year: 2002
    ..Efforts have been made to attract established investigators from related disciplines who can complement the expertise of the LAM investigators. ..
  18. SURFACTANT PROTEIN A IN PULMONARY HOST DEFENSE
    Francis McCormack; Fiscal Year: 2002
    ..These studies will elucidate the role of SP-A in the innate immune defense of the lung, and may assist in the design of optimal antimicrobial strategies. ..
  19. PHASE III TRIAL FO SIROLIMUS IN LYMPHANGIOLEIOMYLMATOSIS
    Francis McCormack; Fiscal Year: 2009
    ..Patient safety will be monitored by an NIH Data Safety Monitoring Board (DSMB). The MILES trial is designed as a pivotal study to determine if sirolimus is effective in stabilizing or improving lung function in patients with LAM. ..