Serpinh1

Summary

Gene Symbol: Serpinh1
Description: serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
Alias: Cbp2, Serpinh2, 47 kDa heat shock protein, GP46, collagen binding protein 2, collagen-binding protein, colligin, serine (or cysteine) peptidase inhibitor, clade H, member 1, serine (or cysteine) proteinase inhibitor, clade H (heat shock protein 47), member 1, serine (or cysteine) proteinase inhibitor, clade H (heat shock protein 47), member 2, serine (or cysteine) proteinase inhibitor, clade H, member 1, serine proteinase inhibitor, clade H (heat shock protein 47), member 1, serpin H1, serpin peptidase inhibitor, clade H, member 1
Species: rat

Top Publications

  1. doi Heat shock protein 47 (HSP47) antisense oligonucleotides reduce cardiac remodeling and improve cardiac function in a rat model of myocardial infarction
    S Hagiwara
    Department of Anesthesiology and Intensive Care Medicine, Oita University Faculty of Medicine, Yufu City, Japan
    Thorac Cardiovasc Surg 59:386-92. 2011
  2. pmc HSP47 regulates ECM accumulation in renal proximal tubular cells induced by TGF-β1 through ERK1/2 and JNK MAPK pathways
    Hong Bo Xiao
    Department of Nephrology, The Second Xiangya Hospital, Kidney Institute of Central South University, No 139 Remin Middle Rd, Changsha, Hunan, China
    Am J Physiol Renal Physiol 303:F757-65. 2012
  3. ncbi A collagen-binding protein in the endoplasmic reticulum of myoblasts exhibits relationship with serine protease inhibitors
    E P Clarke
    Department of Biochemistry, University of Western Ontario, London, Canada
    J Biol Chem 266:17230-5. 1991
  4. ncbi Partial characterization of a collagen-binding, differentiation-related glycoprotein from skeletal myoblasts
    D Nandan
    Department of Biochemistry, University of Western Ontario, London, Canada
    Arch Biochem Biophys 278:291-6. 1990
  5. ncbi The human genome has only one functional hsp47 gene (CBP2) and a pseudogene (pshsp47)
    N Nagai
    Department of Molecular and Cellular Biology, Institute for Frontier Medical Sciences, Kyoto University, Sakyo ku, Kyoto 606 8397, CREST, JST, Japan
    Gene 227:241-8. 1999
  6. ncbi Antisense oligonucleotides against collagen-binding stress protein HSP47 suppress peritoneal fibrosis in rats
    Tomoya Nishino
    Second Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki, Japan
    Kidney Int 64:887-96. 2003
  7. ncbi Inhibition of HSP70 and a collagen-specific molecular chaperone (HSP47) expression in rat osteoblasts by microgravity
    Yasuhiro Kumei
    Graduate School of Tokyo Medical and Dental University, Tokyo 113 8549, Japan
    Ann N Y Acad Sci 1010:476-80. 2003
  8. ncbi Identification of hypertension-related genes through an integrated genomic-transcriptomic approach
    Chana Yagil
    Israel Rat Genome Center and Laboratory for Molecular Medicine, Department of Nephrology and Hypertension, Faculty of Health Sciences, Barzilai Medical Center Campus of the Ben Gurion University, Ashkelon, Israel
    Circ Res 96:617-25. 2005
  9. ncbi The molecular chaperone HSP47 rapidly senses gravitational changes in myoblasts
    Asami Oguro
    Department of Life Sciences, The Graduate School of Arts and Sciences, The University of Tokyo, Tokyo 153 8902, Japan
    Genes Cells 11:1253-65. 2006

Scientific Experts

  • Satoshi Hagiwara
  • Yasuhiro Kumei
  • Hong Bo Xiao
  • Asami Oguro
  • Chana Yagil
  • Tomoya Nishino
  • Ying Hong Liu
  • Yashpal S Kanwar
  • Shi kun Yang
  • Fu You Liu
  • Rui Hong Liu
  • Yuan Chen Xia
  • Li Xiao
  • Ming Zhan
  • Jin Lei Lv
  • Guang Hui Ling
  • Qin Kai Chen
  • Lin Sun
  • Jun Li
  • N Nagai
  • Yoriko Atomi
  • Yoshinobu Fujita
  • Kazuhiro Nagata
  • Takashi Sakurai
  • Sachiko Lee
  • Hiroshi Kubota
  • Marina Sapojnikov
  • Detlev Ganten
  • Yoram Yagil
  • Friedrich C Luft
  • Herbert Schulz
  • Norbert Hubner
  • Jan Monti
  • Yoshiyuki Ozono
  • Akira Furusu
  • Katsushige Abe
  • Takashi Harada
  • Masanobu Miyazaki
  • Shigeru Kohno
  • Yoko Mishima
  • Takehiko Koji
  • N Hosokawa
  • K Nagata
  • Y Tetuya
  • E H Ball
  • G A Cates
  • D Nandan
  • E P Clarke
  • B D Sanwal

Detail Information

Publications9

  1. doi Heat shock protein 47 (HSP47) antisense oligonucleotides reduce cardiac remodeling and improve cardiac function in a rat model of myocardial infarction
    S Hagiwara
    Department of Anesthesiology and Intensive Care Medicine, Oita University Faculty of Medicine, Yufu City, Japan
    Thorac Cardiovasc Surg 59:386-92. 2011
    ..The 47 kD heat shock protein 47 (HSP47) is a collagen-specific molecular chaperone that plays a major role during procollagen processing and/or secretion...
  2. pmc HSP47 regulates ECM accumulation in renal proximal tubular cells induced by TGF-β1 through ERK1/2 and JNK MAPK pathways
    Hong Bo Xiao
    Department of Nephrology, The Second Xiangya Hospital, Kidney Institute of Central South University, No 139 Remin Middle Rd, Changsha, Hunan, China
    Am J Physiol Renal Physiol 303:F757-65. 2012
    ....
  3. ncbi A collagen-binding protein in the endoplasmic reticulum of myoblasts exhibits relationship with serine protease inhibitors
    E P Clarke
    Department of Biochemistry, University of Western Ontario, London, Canada
    J Biol Chem 266:17230-5. 1991
    Several cDNA clones encoding a 46-kDa collagen-binding glycoprotein (gp46) from rat skeletal myoblasts were isolated and sequenced...
  4. ncbi Partial characterization of a collagen-binding, differentiation-related glycoprotein from skeletal myoblasts
    D Nandan
    Department of Biochemistry, University of Western Ontario, London, Canada
    Arch Biochem Biophys 278:291-6. 1990
    A 46-kDa glycoprotein, gp46, which binds collagen has been purified to homogeneity from L6 rat skeletal myoblasts...
  5. ncbi The human genome has only one functional hsp47 gene (CBP2) and a pseudogene (pshsp47)
    N Nagai
    Department of Molecular and Cellular Biology, Institute for Frontier Medical Sciences, Kyoto University, Sakyo ku, Kyoto 606 8397, CREST, JST, Japan
    Gene 227:241-8. 1999
    ..No transcript corresponding to colligin, which was reported to be a human homologue of hsp47, was found...
  6. ncbi Antisense oligonucleotides against collagen-binding stress protein HSP47 suppress peritoneal fibrosis in rats
    Tomoya Nishino
    Second Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki, Japan
    Kidney Int 64:887-96. 2003
    ..In the present study, we examined the effect of HSP47 antisense oligonucleotides (ODNs) on the development of experimental peritoneal fibrosis induced by daily intraperitoneal injections of chlorhexidine gluconate (CG)...
  7. ncbi Inhibition of HSP70 and a collagen-specific molecular chaperone (HSP47) expression in rat osteoblasts by microgravity
    Yasuhiro Kumei
    Graduate School of Tokyo Medical and Dental University, Tokyo 113 8549, Japan
    Ann N Y Acad Sci 1010:476-80. 2003
    ..Microgravity differentially modulated the expression of molecular chaperones in osteoblasts, which might be involved in induction and/or prevention of osteopenia in space...
  8. ncbi Identification of hypertension-related genes through an integrated genomic-transcriptomic approach
    Chana Yagil
    Israel Rat Genome Center and Laboratory for Molecular Medicine, Department of Nephrology and Hypertension, Faculty of Health Sciences, Barzilai Medical Center Campus of the Ben Gurion University, Ashkelon, Israel
    Circ Res 96:617-25. 2005
    ..RT-PCR confirmed 7 genes, leaving TcTex1, Myadm, Lisch7, Axl-like, Fah, PRC1-like, and Serpinh1. None of these genes has been implicated in hypertension before...
  9. ncbi The molecular chaperone HSP47 rapidly senses gravitational changes in myoblasts
    Asami Oguro
    Department of Life Sciences, The Graduate School of Arts and Sciences, The University of Tokyo, Tokyo 153 8902, Japan
    Genes Cells 11:1253-65. 2006
    ..The gravity-regulated HSP47 may play a role in the maintenance of the extracellular matrix by modulating collagen production at the primary stage of adaptation...