Serpinh1

Summary

Gene Symbol: Serpinh1
Description: serpin family H member 1
Alias: Cbp2, Serpinh2, serpin H1, 47 kDa heat shock protein, GP46, collagen binding protein 2, collagen-binding protein, colligin, serine (or cysteine) peptidase inhibitor, clade H, member 1, serine (or cysteine) proteinase inhibitor, clade H (heat shock protein 47), member 1, serine (or cysteine) proteinase inhibitor, clade H (heat shock protein 47), member 2, serine (or cysteine) proteinase inhibitor, clade H, member 1, serine proteinase inhibitor, clade H (heat shock protein 47), member 1, serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1), serpin peptidase inhibitor, clade H, member 1
Species: rat

Top Publications

  1. pmc MiR-29b inhibits collagen maturation in hepatic stellate cells through down-regulating the expression of HSP47 and lysyl oxidase
    Yifei Zhang
    Center for Pharmacogenetics, Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, Pittsburgh, PA 15261, United States
    Biochem Biophys Res Commun 446:940-4. 2014
  2. doi Evaluation of Hsp47 expression in heat-stressed rat myocardial cells in vitro and in vivo
    A Abdelnasir
    Department of Basic Veterinary Science, College of Veterinary Medicine, Nanjing Agricultural University, Weigang 1, Nanjing, China
    Genet Mol Res 13:10787-802. 2014
  3. doi Heat shock protein 47 (HSP47) antisense oligonucleotides reduce cardiac remodeling and improve cardiac function in a rat model of myocardial infarction
    S Hagiwara
    Department of Anesthesiology and Intensive Care Medicine, Oita University Faculty of Medicine, Yufu City, Japan
    Thorac Cardiovasc Surg 59:386-92. 2011
  4. pmc HSP47 regulates ECM accumulation in renal proximal tubular cells induced by TGF-β1 through ERK1/2 and JNK MAPK pathways
    Hong Bo Xiao
    Department of Nephrology, The Second Xiangya Hospital, Kidney Institute of Central South University, No 139 Remin Middle Rd, Changsha, Hunan, China
    Am J Physiol Renal Physiol 303:F757-65. 2012
  5. ncbi A collagen-binding protein in the endoplasmic reticulum of myoblasts exhibits relationship with serine protease inhibitors
    E P Clarke
    Department of Biochemistry, University of Western Ontario, London, Canada
    J Biol Chem 266:17230-5. 1991
  6. ncbi Partial characterization of a collagen-binding, differentiation-related glycoprotein from skeletal myoblasts
    D Nandan
    Department of Biochemistry, University of Western Ontario, London, Canada
    Arch Biochem Biophys 278:291-6. 1990
  7. ncbi The human genome has only one functional hsp47 gene (CBP2) and a pseudogene (pshsp47)
    N Nagai
    Department of Molecular and Cellular Biology, Institute for Frontier Medical Sciences, Kyoto University, Sakyo ku, Kyoto 606 8397, CREST, JST, Japan
    Gene 227:241-8. 1999
  8. ncbi Antisense oligonucleotides against collagen-binding stress protein HSP47 suppress peritoneal fibrosis in rats
    Tomoya Nishino
    Second Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki, Japan
    Kidney Int 64:887-96. 2003
  9. ncbi Inhibition of HSP70 and a collagen-specific molecular chaperone (HSP47) expression in rat osteoblasts by microgravity
    Yasuhiro Kumei
    Graduate School of Tokyo Medical and Dental University, Tokyo 113 8549, Japan
    Ann N Y Acad Sci 1010:476-80. 2003
  10. ncbi Identification of hypertension-related genes through an integrated genomic-transcriptomic approach
    Chana Yagil
    Israel Rat Genome Center and Laboratory for Molecular Medicine, Department of Nephrology and Hypertension, Faculty of Health Sciences, Barzilai Medical Center Campus of the Ben Gurion University, Ashkelon, Israel
    Circ Res 96:617-25. 2005

Scientific Experts

  • Satoshi Hagiwara
  • Yasuhiro Kumei
  • A Abdelnasir
  • Yifei Zhang
  • Hong Bo Xiao
  • Asami Oguro
  • Chana Yagil
  • Tomoya Nishino
  • N Kemper
  • Wen Xie
  • S Tang
  • Jiang Li
  • Ming Sun
  • Mohammed Ghazwani
  • Jie Fan
  • H B Chen
  • J R Sun
  • Song Li
  • J Hartung
  • E D Bao
  • Fengtian He
  • Donna B Stolz
  • Y F Cheng
  • Guang Hui Ling
  • Ming Zhan
  • Jin Lei Lv
  • Li Xiao
  • Rui Hong Liu
  • Lin Sun
  • Jun Li
  • Yashpal S Kanwar
  • Fu You Liu
  • Qin Kai Chen
  • Shi kun Yang
  • Ying Hong Liu
  • Yuan Chen Xia
  • N Nagai
  • Hiroshi Kubota
  • Yoriko Atomi
  • Takashi Sakurai
  • Kazuhiro Nagata
  • Yoshinobu Fujita
  • Sachiko Lee
  • Yoram Yagil
  • Jan Monti
  • Friedrich C Luft
  • Herbert Schulz
  • Detlev Ganten
  • Norbert Hubner
  • Marina Sapojnikov
  • Masanobu Miyazaki
  • Yoshiyuki Ozono
  • Takashi Harada
  • Akira Furusu
  • Katsushige Abe
  • Shigeru Kohno
  • Yoko Mishima
  • Takehiko Koji
  • N Hosokawa
  • Y Tetuya
  • K Nagata
  • D Nandan
  • E P Clarke
  • G A Cates
  • B D Sanwal
  • E H Ball

Detail Information

Publications11

  1. pmc MiR-29b inhibits collagen maturation in hepatic stellate cells through down-regulating the expression of HSP47 and lysyl oxidase
    Yifei Zhang
    Center for Pharmacogenetics, Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, Pittsburgh, PA 15261, United States
    Biochem Biophys Res Commun 446:940-4. 2014
    ..These results demonstrated that miR-29b is involved in regulating the post-translational processing of ECM and fibril formation...
  2. doi Evaluation of Hsp47 expression in heat-stressed rat myocardial cells in vitro and in vivo
    A Abdelnasir
    Department of Basic Veterinary Science, College of Veterinary Medicine, Nanjing Agricultural University, Weigang 1, Nanjing, China
    Genet Mol Res 13:10787-802. 2014
    ..The results suggest that Hsp47 turnover may increase during heat stress or that Hsp47 consumption exceeds its production...
  3. doi Heat shock protein 47 (HSP47) antisense oligonucleotides reduce cardiac remodeling and improve cardiac function in a rat model of myocardial infarction
    S Hagiwara
    Department of Anesthesiology and Intensive Care Medicine, Oita University Faculty of Medicine, Yufu City, Japan
    Thorac Cardiovasc Surg 59:386-92. 2011
    ..The 47 kD heat shock protein 47 (HSP47) is a collagen-specific molecular chaperone that plays a major role during procollagen processing and/or secretion...
  4. pmc HSP47 regulates ECM accumulation in renal proximal tubular cells induced by TGF-β1 through ERK1/2 and JNK MAPK pathways
    Hong Bo Xiao
    Department of Nephrology, The Second Xiangya Hospital, Kidney Institute of Central South University, No 139 Remin Middle Rd, Changsha, Hunan, China
    Am J Physiol Renal Physiol 303:F757-65. 2012
    ....
  5. ncbi A collagen-binding protein in the endoplasmic reticulum of myoblasts exhibits relationship with serine protease inhibitors
    E P Clarke
    Department of Biochemistry, University of Western Ontario, London, Canada
    J Biol Chem 266:17230-5. 1991
    Several cDNA clones encoding a 46-kDa collagen-binding glycoprotein (gp46) from rat skeletal myoblasts were isolated and sequenced...
  6. ncbi Partial characterization of a collagen-binding, differentiation-related glycoprotein from skeletal myoblasts
    D Nandan
    Department of Biochemistry, University of Western Ontario, London, Canada
    Arch Biochem Biophys 278:291-6. 1990
    A 46-kDa glycoprotein, gp46, which binds collagen has been purified to homogeneity from L6 rat skeletal myoblasts...
  7. ncbi The human genome has only one functional hsp47 gene (CBP2) and a pseudogene (pshsp47)
    N Nagai
    Department of Molecular and Cellular Biology, Institute for Frontier Medical Sciences, Kyoto University, Sakyo ku, Kyoto 606 8397, CREST, JST, Japan
    Gene 227:241-8. 1999
    ..No transcript corresponding to colligin, which was reported to be a human homologue of hsp47, was found...
  8. ncbi Antisense oligonucleotides against collagen-binding stress protein HSP47 suppress peritoneal fibrosis in rats
    Tomoya Nishino
    Second Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki, Japan
    Kidney Int 64:887-96. 2003
    ..In the present study, we examined the effect of HSP47 antisense oligonucleotides (ODNs) on the development of experimental peritoneal fibrosis induced by daily intraperitoneal injections of chlorhexidine gluconate (CG)...
  9. ncbi Inhibition of HSP70 and a collagen-specific molecular chaperone (HSP47) expression in rat osteoblasts by microgravity
    Yasuhiro Kumei
    Graduate School of Tokyo Medical and Dental University, Tokyo 113 8549, Japan
    Ann N Y Acad Sci 1010:476-80. 2003
    ..Microgravity differentially modulated the expression of molecular chaperones in osteoblasts, which might be involved in induction and/or prevention of osteopenia in space...
  10. ncbi Identification of hypertension-related genes through an integrated genomic-transcriptomic approach
    Chana Yagil
    Israel Rat Genome Center and Laboratory for Molecular Medicine, Department of Nephrology and Hypertension, Faculty of Health Sciences, Barzilai Medical Center Campus of the Ben Gurion University, Ashkelon, Israel
    Circ Res 96:617-25. 2005
    ..RT-PCR confirmed 7 genes, leaving TcTex1, Myadm, Lisch7, Axl-like, Fah, PRC1-like, and Serpinh1. None of these genes has been implicated in hypertension before...
  11. ncbi The molecular chaperone HSP47 rapidly senses gravitational changes in myoblasts
    Asami Oguro
    Department of Life Sciences, The Graduate School of Arts and Sciences, The University of Tokyo, Tokyo 153 8902, Japan
    Genes Cells 11:1253-65. 2006
    ..The gravity-regulated HSP47 may play a role in the maintenance of the extracellular matrix by modulating collagen production at the primary stage of adaptation...