Serpine1

Summary

Gene Symbol: Serpine1
Description: serpin family E member 1
Alias: PAI1A, Pai1, Pai1aa, Planh, RATPAI1A, plasminogen activator inhibitor 1, PAI, PAI-1, endothelial plasminogen activator inhibitor, serine (or cysteine) peptidase inhibitor, clade E, member 1, serine (or cysteine) proteinase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1, serine (or cysteine) proteinase inhibitor, clade E, member 1, serine (or cysteine) proteinase inhibitor, member 1, serpin E1, serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
Species: rat

Top Publications

  1. ncbi Upregulated expression of transforming growth factor-beta, type IV collagen, and plasminogen activator inhibitor-1 mRNA are decreased after release of unilateral ureteral obstruction
    Yukihiko Ogata
    Department of Urology, Tohoku University Graduate School of Medicine, Sendai, Japan
    Tohoku J Exp Med 197:159-68. 2002
  2. ncbi The effects of pharmacological PAI-1 inhibition on thrombus formation and neointima formation after arterial injury
    Jun ichi Suzuki
    Tokyo Medical and Dental University, Graduate School of Medicine, Department of Cardiovascular Medicine, 1 5 45, Yushima, Bunkyo ku, Tokyo 113 8519, Japan
    Expert Opin Ther Targets 12:783-94. 2008
  3. doi Establishment of a peritoneal mesothelial cell line from a transgenic rat harbouring the temperature-sensitive simian virus 40 large T-antigen gene
    Yoko Hotta
    Division of Nephrology, Department of Internal Medicine, Juntendo University Faculty of Medicine, Bunkyo ku, Tokyo 113 8421, Japan
    Nephrol Dial Transplant 25:1825-32. 2010
  4. ncbi Insertion/deletion plasminogen activator inhibitor 1 and insertion/deletion angiotensin-converting enzyme gene polymorphisms in diabetic retinopathy in type 2 diabetes
    Mojca Globocnik-Petrovic
    Eye Clinic, University Medical Centre Ljubljana, Ljubljana, Slovenia
    Ophthalmologica 217:219-24. 2003
  5. ncbi Elevated levels of plasminogen activator inhibitor-1 in pulmonary edema fluid are associated with mortality in acute lung injury
    Priya Prabhakaran
    Department of Pediatrics, University of Alabama, Birmingham, Alabama 35294, USA
    Am J Physiol Lung Cell Mol Physiol 285:L20-8. 2003
  6. ncbi PAI-1 Gene 4G/5G polymorphism and risk of type 2 diabetes in a population-based sample
    James B Meigs
    General Medicine Division, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Obesity (Silver Spring) 14:753-8. 2006
  7. pmc Pathogenetic and prognostic significance of altered coagulation and fibrinolysis in acute lung injury/acute respiratory distress syndrome
    Lorraine B Ware
    Division of Allergy, Pulmonary, and Critical Care Medicine, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA
    Crit Care Med 35:1821-8. 2007
  8. doi Inhibition of plasminogen activator inhibitor-1 expression by siRNA in rat hepatic stellate cells
    Ping Fang Hu
    Department of Gastroenterology, Changzheng Hospital, Second Military Medical University, Shanghai, China
    J Gastroenterol Hepatol 23:1917-25. 2008
  9. pmc 4G/5G polymorphism of plasminogen activator inhibitor-1 gene is associated with mortality in intensive care unit patients with severe pneumonia
    Anil Sapru
    Department of Pediatrics, Division of Critical Care Medicine, University of California San Francisco, San Francisco, CA 94143, USA
    Anesthesiology 110:1086-91. 2009
  10. doi Diabetic retinopathy, PAI-1 4G/5G and -844G/A polymorphisms, and changes in circulating PAI-1 levels in Tunisian type 2 diabetes patients
    I Ezzidi
    Faculty of Pharmacy of Monastir, University of Monastir, Monastir, Tunisia
    Diabetes Metab 35:214-9. 2009

Research Grants

Scientific Experts

Detail Information

Publications120 found, 100 shown here

  1. ncbi Upregulated expression of transforming growth factor-beta, type IV collagen, and plasminogen activator inhibitor-1 mRNA are decreased after release of unilateral ureteral obstruction
    Yukihiko Ogata
    Department of Urology, Tohoku University Graduate School of Medicine, Sendai, Japan
    Tohoku J Exp Med 197:159-68. 2002
    ..transforming growth factor-beta (TGF-beta), type IV collagen (collagen IV), and plasminogen activator inhibitor-1 (PAI-1) were examined by reverse transcription-polymerase chain reaction (RT-PCR) up to 28 days...
  2. ncbi The effects of pharmacological PAI-1 inhibition on thrombus formation and neointima formation after arterial injury
    Jun ichi Suzuki
    Tokyo Medical and Dental University, Graduate School of Medicine, Department of Cardiovascular Medicine, 1 5 45, Yushima, Bunkyo ku, Tokyo 113 8519, Japan
    Expert Opin Ther Targets 12:783-94. 2008
    Plasminogen activator inhibitor (PAI)-1 plays a role in neointimal formation after percutaneous coronary intervention (PCI), the effect of overexpression or lack of PAI-1 is controversial...
  3. doi Establishment of a peritoneal mesothelial cell line from a transgenic rat harbouring the temperature-sensitive simian virus 40 large T-antigen gene
    Yoko Hotta
    Division of Nephrology, Department of Internal Medicine, Juntendo University Faculty of Medicine, Bunkyo ku, Tokyo 113 8421, Japan
    Nephrol Dial Transplant 25:1825-32. 2010
    ..In this study, we established a novel MC line from tsSV40T Tg rats and evaluated its characteristics...
  4. ncbi Insertion/deletion plasminogen activator inhibitor 1 and insertion/deletion angiotensin-converting enzyme gene polymorphisms in diabetic retinopathy in type 2 diabetes
    Mojca Globocnik-Petrovic
    Eye Clinic, University Medical Centre Ljubljana, Ljubljana, Slovenia
    Ophthalmologica 217:219-24. 2003
    In an association study, the relationship between the insertion/deletion (I/D) plasminogen activator inhibitor 1 (PAI-1) gene polymorphism or the I/D angiotensin 1-converting enzyme (ACE) gene polymorphism and the development of diabetic ..
  5. ncbi Elevated levels of plasminogen activator inhibitor-1 in pulmonary edema fluid are associated with mortality in acute lung injury
    Priya Prabhakaran
    Department of Pediatrics, University of Alabama, Birmingham, Alabama 35294, USA
    Am J Physiol Lung Cell Mol Physiol 285:L20-8. 2003
    ..Levels of the fibrinolytic protease inhibitor, plasminogen activator inhibitor-1 (PAI-1), are too low in bronchoalveolar lavage to address its prognostic significance...
  6. ncbi PAI-1 Gene 4G/5G polymorphism and risk of type 2 diabetes in a population-based sample
    James B Meigs
    General Medicine Division, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Obesity (Silver Spring) 14:753-8. 2006
    Elevated plasma levels of plasminogen activator inhibitor-1 (PAI-1) increase risk for type 2 diabetes...
  7. pmc Pathogenetic and prognostic significance of altered coagulation and fibrinolysis in acute lung injury/acute respiratory distress syndrome
    Lorraine B Ware
    Division of Allergy, Pulmonary, and Critical Care Medicine, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA
    Crit Care Med 35:1821-8. 2007
    ..However, direct evidence for the contribution of abnormalities in coagulation and fibrinolysis proteins to outcomes in patients with acute lung injury/acute respiratory distress syndrome is lacking...
  8. doi Inhibition of plasminogen activator inhibitor-1 expression by siRNA in rat hepatic stellate cells
    Ping Fang Hu
    Department of Gastroenterology, Changzheng Hospital, Second Military Medical University, Shanghai, China
    J Gastroenterol Hepatol 23:1917-25. 2008
    ..The aim of this study was to detect the role of plasminogen activator inhibitor-1 (PAI-1) during liver fibrogenesis and investigate the functional effects of PAI-1 gene silencing in rat hepatic stellate ..
  9. pmc 4G/5G polymorphism of plasminogen activator inhibitor-1 gene is associated with mortality in intensive care unit patients with severe pneumonia
    Anil Sapru
    Department of Pediatrics, Division of Critical Care Medicine, University of California San Francisco, San Francisco, CA 94143, USA
    Anesthesiology 110:1086-91. 2009
    Higher plasma and pulmonary edema fluid levels of plasminogen activator inhibitor-1 (PAI-1) are associated with increased mortality in patients with pneumonia and acute lung injury...
  10. doi Diabetic retinopathy, PAI-1 4G/5G and -844G/A polymorphisms, and changes in circulating PAI-1 levels in Tunisian type 2 diabetes patients
    I Ezzidi
    Faculty of Pharmacy of Monastir, University of Monastir, Monastir, Tunisia
    Diabetes Metab 35:214-9. 2009
    The association of altered plasminogen activator inhibitor (PAI)-1 levels and PAI-1 polymorphisms (4G/5G and -844G/A) with diabetic retinopathy (DR) was investigated in 856 type 2 diabetes (T2D) patients, of whom 383 presented with (DR ..
  11. ncbi Alveolar plasminogen activator inhibitor-1 predicts ARDS in aspiration pneumonitis
    Ali A El Solh
    Division of Pulmonary, Critical Care, and Sleep Medicine, Erie County Medical Center, 462 Grider Street, Buffalo, NY 14215, USA
    Intensive Care Med 32:110-5. 2006
    To test the hypothesis that alveolar plasminogen activator inhibitor-1 (PAI-1) can identify patients with witnessed aspiration at risk for progression to acute respiratory distress syndrome (ARDS).
  12. ncbi Isolation and characterization of the rat plasminogen activator inhibitor-1 gene
    C J Bruzdzinski
    Department of Human Genetics, University of Michigan Medical School, Ann Arbor 48109 0618
    J Biol Chem 265:2078-85. 1990
    ..plasminogen activator activity in HTC rat hepatoma cells primarily by modulating plasminogen activator inhibitor (PAI-1) gene expression...
  13. ncbi MAPK/AP-1-dependent regulation of PAI-1 gene expression by TGF-beta in rat mesangial cells
    Baoliang Guo
    Department of Medicine, Shiga University of Medical Science, Otsu, Shiga, Japan
    Kidney Int 68:972-84. 2005
    ..growth factor-beta (TGF-beta)-induced expression of various genes, including plasminogen activator inhibitor-1 (PAI-1)...
  14. ncbi Polymorphisms of the plasminogen activator inhibitor-1 gene in type 1 and type 2 diabetes, and in patients with diabetic retinopathy
    M W Mansfield
    Division of Medicine, School of Medicine, University of Leeds, Leeds General Infirmary, UK
    Thromb Haemost 71:731-6. 1994
    To identify whether genotype contributes to the difference in PAI-1 levels in type 1 and type 2 diabetic subjects and whether genotype relates to the development of retinopathy, a Hind III restriction fragment length polymorphism and two ..
  15. ncbi Studies on the role of plasminogen activators and plasminogen activator inhibitor type-1 in rat corpus luteum of pregnancy
    Y X Liu
    State Key Laboratory of Reproductive Biology, Chinese Academy of Sciences, Beijing, China
    Biol Reprod 53:1131-8. 1995
    ..On the basis of the data provided in this study and similar findings in monkeys, we conclude that endogenously produced tPA in late phase of CL development may regulate luteal regression through local autocrine or paracrine action...
  16. ncbi Bactericidal/permeability-increasing protein ameliorates hypercoagulability after hemorrhagic shock
    M Yamashita
    Department of Emergency Medicine, University of Tsukuba, Japan
    Thromb Res 87:323-9. 1997
    We recently showed that both plasminogen activator inhibitor-1 (PAI-1) and tissue factor (TF) are induced after a massive hemorrhage...
  17. ncbi Monoclonal antibody-based immunoassays for the specific quantitation of rat PAI-1 antigen and activity in biological samples
    T H Ngo
    Laboratory for Pharmaceutical Biology and Phytopharmacology, Faculty of Pharmaceutical Sciences, Katholieke Universiteit Leuven, Belgium
    Thromb Haemost 79:808-12. 1998
    Two enzyme-linked immunosorbent assays (ELISAs) for the quantitation of rat plasminogen activator inhibitor-1 (PAI-1) antigen and activity, respectively, in biological fluids were developed using monoclonal antibodies raised against ..
  18. ncbi Cyclic nucleotide regulation of type-1 plasminogen activator-inhibitor mRNA stability in rat hepatoma cells. Identification of cis-acting sequences
    J H Heaton
    Departments of Human Genetics and Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan 48109 0618, USA
    J Biol Chem 273:14261-8. 1998
    Type-1 plasminogen activator-inhibitor (PAI-1) is a major physiologic inhibitor of plasminogen activation...
  19. ncbi P2Y receptor regulation of PAI-1 expression in vascular smooth muscle cells
    J L Bouchie
    Research Division, Joslin Diabetes Center, Harvard Medical School, Boston, MA 02215, USA
    Arterioscler Thromb Vasc Biol 20:866-73. 2000
    ..In this article, the regulation of plasminogen activator inhibitor-1 (PAI-1) expression in rat aortic smooth muscle cells (RASMCs) by adenine and uridine nucleotides was examined and ..
  20. ncbi Plasminogen activator inhibitor-1 and apolipoprotein E gene polymorphisms and diabetic angiopathy
    L Tarnow
    Steno Diabetes Center, Gentofte, Denmark
    Nephrol Dial Transplant 15:625-30. 2000
    A point mutation in the plasminogen activator inhibitor-1 (PAI-1) gene and a three-allelic variation in the apolipoprotein-E (ApoE) gene have been suggested as risk factors for the development of diabetic micro- and macrovascular ..
  21. ncbi Influence of plasminogen activator inhibitor type 1 on choroidal neovascularization
    V Lambert
    Laboratory of Tumor and Development Biology, University of Liege, B 4000 Liege, Belgium
    FASEB J 15:1021-7. 2001
    High levels of the plasminogen activators, but also their inhibitor, plasminogen activator inhibitor 1 (PAI-1), have been documented in neovascularization of severe ocular pathologies such as diabetic retinopathy or age-related macular ..
  22. ncbi Role of microthrombus formation in the development of ischemia/reperfusion-induced liver injury in rats
    Kenji Okajima
    Department of Laboratory Medicine, Kumamoto University School of Medicine, Japan
    Thromb Haemost 88:473-80. 2002
    ....
  23. ncbi Glucose upregulates plasminogen activator inhibitor-1 gene expression in vascular smooth muscle cells
    Manabu Suzuki
    Department of Endocrinology and Metabolism, Dokkyo University School of Medicine, Mibu, Tochigi 321 0293, Japan
    Life Sci 72:59-66. 2002
    We investigated the effects of high concentrations of glucose on plasminogen activator inhibitor-1 (PAI-1) gene expression in cultured rat vascular smooth muscle cells (VSMC). In response to a high glucose concentration (27...
  24. ncbi Inhibition of retinal neovascularization by intravitreal injection of human rPAI-1 in a rat model of retinopathy of prematurity
    John S Penn
    Department of Ophthalmology and Visual Sciences, Vanderbilt University School of Medicine, 2115 21st Avenue South, 8016 Medical Center East, Nashville, TN 37232 8808, USA
    Invest Ophthalmol Vis Sci 44:5423-9. 2003
    ..essential for the invasive aspect of angiogenesis by increasing synthesis of plasminogen activator inhibitor (PAI)-1...
  25. pmc Reduced cardiac expression of plasminogen activator inhibitor 1 and transforming growth factor beta1 in obese Zucker rats by perindopril
    J E Toblli
    Laboratory of Experimental Medicine, Hospital Aleman, CONICET, Av Pueyrredon 1640, Buenos Aires 1118, Argentina
    Heart 91:80-6. 2005
    ..enzyme inhibition by perindopril can reduce cardiac transforming growth factor beta1 (TGFbeta1) and plasminogen activator inhibitor 1 (PAI-1) and therefore control collagen accumulation in an animal model with the metabolic syndrome ..
  26. ncbi Plasminogen activator inhibitor-1 in the aqueous humor of patients with and without glaucoma
    Jacob Dan
    Department of Biological Chemistry, The Weizmann Institute of Science, Rehovot, Israel
    Arch Ophthalmol 123:220-4. 2005
    To determine the levels of plasminogen activator inhibitor-1 (PAI-1) and total protein in the aqueous humor of patients with glaucoma vs those without glaucoma.
  27. ncbi [Changes of coagulation and fibrinolysis system in bronchoalveolar lavage fluid in lung fibrosis]
    Yan Ping Zhang
    Department of Respiratory Medicine, Second Hospital of Hebei Medical University, Shijiazhuang 050000, China
    Beijing Da Xue Xue Bao 37:516-9. 2005
    ..To investigate the activity of coagulation and fibrinolysis systems in bronchoalveolar lavage fluid (BALF) in lung fibrosis in rats, and to study their role in diagnosis of lung fibrosis...
  28. ncbi Hyperbaric oxygen therapy prevents coagulation disorders in an experimental model of multiple organ failure syndrome
    Francesco Imperatore
    Department of Experimental Medicine, Section of Pharmacology L Donatelli, Faculty of Medicine, Second University of Naples, via Michele Tenore 14, 80137, Naples, Italy
    Intensive Care Med 32:1881-8. 2006
    ..To evaluate the effects of hyperbaric oxygen (HBO) therapy on the coagulation cascade using an experimental model of multiple organ failure syndrome (MOFS)...
  29. pmc The LOC387715 polymorphism, inflammatory markers, smoking, and age-related macular degeneration. A population-based case-control study
    Jie Jin Wang
    Centre for Vision Research, Department of Ophthalmology and Westmead Millennium Institute, University of Sydney, Sydney, Australia
    Ophthalmology 115:693-9. 2008
    ..To assess combined effects on the risk of age-related macular degeneration (AMD) by the LOC387715 polymorphism, smoking, and inflammatory or hemostatic factors...
  30. ncbi Plasminogen activator inhibitor-1 as a predictor of postoperative atrial fibrillation after cardiopulmonary bypass
    Mias Pretorius
    Department of Anesthesiology, Vanderbilt University Medical School, Nashville, TN 37232, USA
    Circulation 116:I1-7. 2007
    ..This study tests the hypothesis that biomarkers predict the development of postoperative AF...
  31. ncbi A DNA enzyme against plasminogen activator inhibitor- type 1 (PAI-1) limits neointima formation after angioplasty in an obese diabetic rodent model
    Piotr Witkowski
    Department of Surgery, Columbia University, College of Surgeons and Physicians, New York, New York, USA
    J Cardiovasc Pharmacol 50:633-40. 2007
    We investigated whether targeted cleavage of PAI-1 mRNA might prevent post-angioplasty neointima formation in diabetic JCR:LA-cp/cp rats with naturally elevated PAI-1 levels...
  32. doi Fibrinolytic inhibitor levels and polymorphisms in Behçet disease and their association with thrombosis
    Jose M Ricart
    Dermatology Service, La Fe University Hospital, Valencia, Spain
    Br J Haematol 141:716-9. 2008
    ..No significant differences were observed in CPB2 (TAFI) Thr325Ile and SERPINE1 (PAI1) 4G/5G polymorphism distribution between patients and controls...
  33. doi Ventilator-induced coagulopathy in experimental Streptococcus pneumoniae pneumonia
    J J Haitsma
    Interdepartmental Division of Critical Care Medicine, University of Toronto, Keenan Research Center, Li Ka Shing Knowledge Institute, St Michael s Hospital, 30 Bond Street, Queen Wing 4 042, Toronto, ON, M5B 1W8 Canada
    Eur Respir J 32:1599-606. 2008
    ..Mechanical ventilation causing ventilator-induced lung injury increases pulmonary coagulopathy in an animal model of Streptococcus pneumoniae pneumonia and results in systemic coagulopathy...
  34. ncbi [Changes of u-PA and PAI-1 expression in the lung tissue of neonatal rats after inhaling high concentration oxygen]
    Xue Yan Liu
    Department of Pediatrics, Shengjing Hospital, China Medical University, Shenyang 110004, China
    Zhonghua Er Ke Za Zhi 46:458-63. 2008
    ..authors established an animal model of CLD induced by inhaling high concentration oxygen (hyperoxia) to investigate the changes and functions of urokinase-plasminogen activator (u-PA) and plasminogen activator inhibitor-1 (PAI-1) in CLD.
  35. doi Aortic length changes during abdominal aortic aneurysm formation, expansion and stabilisation in a rat model
    S Michineau
    CNRS EAC 7054, Centre de Recherches Chirurgicales Dominique Chopin, University Paris, 12 Val de Marne, 8 rue du General Sarrail, 94010 Creteil Cedex, France
    Eur J Vasc Endovasc Surg 40:468-74. 2010
    ..Determinants of extracellular matrix (ECM) destruction/reconstruction balance influencing abdominal aortic aneurysm (AAA) diameter may impact length...
  36. doi Tissue-type plasminogen activator depletion affects the nasal mucosa matrix reconstruction in allergic rhinitis mice
    H Hua
    Department of Otorhinolaryngology, Huadong Hospital, Shanghai Medical College, Fudan University, Shanghai, China
    Allergol Immunopathol (Madr) 39:206-11. 2011
    ..The present study was designed to assess the function of tissue plasminogen activator (t-PA) expression in allergic rhinitis...
  37. doi The expression of fibrinolytic components in chronic paranasal sinus disease
    Takayuki Sejima
    Upper Airway Research Laboratory, Department of Otorhinolaryngology, Ghent University Hospital, Ghent, Belgium
    Am J Rhinol Allergy 25:1-6. 2011
    ..To clarify the relationship between these components and the pathology of CRS, we analyzed fibrinolytic components in sinonasal mucosa of CRS...
  38. pmc Plasminogen activator inhibitor-1 mitigates brain injury in a rat model of infection-sensitized neonatal hypoxia-ischemia
    Dianer Yang
    Division of Developmental Biology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Cereb Cortex 23:1218-29. 2013
    ..Together, because CPAI blocks both proteolytic and nonproteolytic tPA neurotoxicity, it is a promising therapeutics of neonatal HI injury either with or without infection...
  39. pmc siRNA against plasminogen activator inhibitor-1 ameliorates bleomycin-induced lung fibrosis in rats
    Yan Ping Zhang
    Department of Pathophysiology, Hebei Medical University, Shijiazhuang, China
    Acta Pharmacol Sin 33:897-908. 2012
    Plasminogen activator inhibitor-1 (PAI-1) is involved in the progression of pulmonary fibrosis...
  40. doi Valproic acid induces astrocyte-dependent neurite outgrowth from cultured rat primary cortical neuron via modulation of tPA/PAI-1 activity
    Kyu Suk Cho
    Department of Neuroscience, School of Medicine, Konkuk University, Seoul, Korea
    Glia 61:694-709. 2013
    ..The activity of tPA is regulated by an endogenous inhibitor plasminogen activator inhibitor-1 (PAI-1), which is expressed mainly in astrocytes...
  41. doi Effects of gabexate mesilate on coagulopathy and organ dysfunction in rats with endotoxemia: a potential use of thrombelastography in endotoxin-induced sepsis
    Hsin Jung Tsai
    aDepartment of Pharmacology, National Defense Medical Center bDepartment of Anesthesiology, Mackay Memorial Hospital, Taipei, Taiwan cCenter of Coronary Heart Disease, Fu Wai Hospital and Cardiovascular Institute, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China dDepartment of Anesthesiology, Taipei Veterans General Hospital and National Yang Ming University eDepartment of Anesthesiology fGraduate Institute of Aerospace and Undersea Medicine, National Defense Medical Center, Taipei gDepartment of Anesthesiology, Tungs Taichung Metroharbor Hospital, Taichung hDepartment of Pharmacology, Taipei Medical University, Taipei, Taiwan Wen Jinn Liaw and Chin Chen Wu contributed equally to this study
    Blood Coagul Fibrinolysis 26:175-84. 2015
    ..752, P < 0.001, R = 0.566). These results indicate that beneficial effects of anticoagulants (e.g. gabexate mesilate) in endotoxemia could be monitored by TEG per se...
  42. pmc Inhibiting ERK Activation with CI-1040 Leads to Compensatory Upregulation of Alternate MAPKs and Plasminogen Activator Inhibitor-1 following Subtotal Nephrectomy with No Impact on Kidney Fibrosis
    Faith Hannah Nutter
    Academic Unit of Nephrology, Department of Infection and Immunity, Medical School, University of Sheffield, Sheffield, England
    PLoS ONE 10:e0137321. 2015
    ..CI-1040 also increased the expression of plasminogen activator inhibitor-1 (PAI-1), a key inhibitor of plasmin-dependent matrix metalloproteinases...
  43. doi Effect of intra-abdominal administration of ligustrazine nanoparticles nano spray on postoperative peritoneal adhesion in rat model
    Shuai Yan
    Suzhou Hospital of Traditional Chinese Medicine, Suzhou, China
    J Obstet Gynaecol Res 41:1942-50. 2015
    ..We aimed to evaluate the preventive effect of the ligustrazine nanoparticles nano spray (LNNS) for postoperative peritoneal adhesions in female rat models...
  44. doi TGF-β1 and Serpine 1 expression changes in traumatic deep vein thrombosis
    J W Mo
    Department of Orthopedic Surgery, The First Affiliated Hospital of Gannan Medical University, Ganzhou, Jiangxi Province, China
    Genet Mol Res 14:13835-42. 2015
    ..Together, these results suggested that TGF-β1 and Serpine 1 overexpression might play an important role in DVT formation and have predictive values...
  45. doi Treatment with oestrogen-receptor agonists or oxytocin in conjunction with exercise protects against myocardial infarction in ovariectomized rats
    Erman Caner Bulut
    Department of Physiology, School of Medicine, Marmara University, Istanbul, Turkey
    Exp Physiol 101:612-27. 2016
    ..Oestrogen receptor agonists, as well as oxytocin, in conjunction with exercise may be effective new therapeutics to protect against myocardial ischaemia in postmenopausal women...
  46. doi Differential contributions of platelets and fibrinogen to early coagulopathy in a rat model of hemorrhagic shock
    Hayley L Letson
    Heart, Trauma and Sepsis Research Laboratory, Australian Institute of Tropical Health and Medicine, College of Medicine and Dentistry, James Cook University, Queensland 4811, Australia Electronic address
    Thromb Res 141:58-65. 2016
    ..The mechanisms of early traumatic-induced coagulopathy are not well understood. Our aim was to examine the role of platelets and fibrinogen to early coagulopathy in the rat after hemorrhagic shock...
  47. doi Combination of Ligusticum chuanxiong and Radix Paeoniae ameliorate focal cerebral ischemic in MCAO rats via endoplasmic reticulum stress-dependent apoptotic signaling pathway
    Junfei Gu
    Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine, Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210023, PR China Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210028, PR China State Key Laboratory Breeding Base of Dao di Herbs, China Academy of Chinese Medical Sciences, Beijing, 100700, PR China Key Laboratory of New Drug Delivery System of Chinese Materia Medica, Jiangsu Provincial Academy of Chinese Medicine, Nanjing, Jiangsu 210028, PR China
    J Ethnopharmacol 187:313-24. 2016
    ..This study was conducted to evaluate the combinative effects of XS on MCAO rats and explore the underlying mechanisms...
  48. ncbi [Effect of amiloride on the pathology of a rat model of chronic obstructive pulmonary disease]
    Xiu di Han
    Department of Respiratory Medicine, Qilu Hospital of Shandong University, Jinan 250012, China
    Zhonghua Jie He He Hu Xi Za Zhi 30:363-7. 2007
    ....
  49. ncbi Epistatic effect of plasminogen activator inhibitor 1 and beta-fibrinogen genes on risk of glomerular microthrombosis in lupus nephritis: interaction with environmental/clinical factors
    Rujun Gong
    Research Institute of Nephrology, Jinling Hospital, Nanjing University School of Medicine, Nanjing, China
    Arthritis Rheum 56:1608-17. 2007
    ..We undertook this study to determine whether genetic variations of hemostasis factors, such as plasminogen activator inhibitor 1 (PAI-1) and fibrinogen, affect the risk of GMT.
  50. doi Poly(ADP-ribose) polymerase-1 mediates angiotensin II-induced expression of plasminogen activator inhibitor-1 and fibronectin in rat mesangial cells
    Hengmei Zhu
    Department of Nephrology, The First Affiliated Hospital, Sun Yat Sen University, Guangzhou, China
    Kidney Blood Press Res 34:320-7. 2011
    To investigate the effects of poly(ADP-ribose) polymerase-1 (PARP-1) on angiotensin II (Ang II)-induced plasminogen activator inhibitor-1 (PAI-1) and fibronectin (FN) in rat mesangial cells (RMCs).
  51. doi Postnatal early overnutrition dysregulates the intrarenal renin-angiotensin system and extracellular matrix-linked molecules in juvenile male rats
    Hyung Eun Yim
    Department of Pediatrics, College of Medicine, Korea University, Seoul, Korea
    J Nutr Biochem 23:937-45. 2012
    ..05). By contrast, the plasminogen activator inhibitor (PAI)-1 and matrix metalloproteinase (MMP)-9 expression decreased in the overnutrition group (P<.05)...
  52. pmc Fructose rich diet-induced high plasminogen activator inhibitor-1 (PAI-1) production in the adult female rat: protective effect of progesterone
    Daniel Castrogiovanni
    Neuroendocrine Unit, IMBICE CONICET CICPBA, 1900 La Plata, Argentina
    Nutrients 4:1137-50. 2012
    ..CT-ND) plasma concentrations of lipids, leptin, adiponectin and plasminogen activator inhibitor-1 (PAI-1). Lipidemia and adiponectinemia were high (vs. P4-ND) in P4-FRD rats...
  53. ncbi Regulatory sequences and protein-binding sites involved in the expression of the rat plasminogen activator inhibitor-1 gene
    M R Johnson
    Department of Human Genetics, University of Michigan Medical School, Ann Arbor 48109 0618
    J Biol Chem 267:12202-10. 1992
    Plasminogen activator inhibitor-1 (PAI-1) is a serine protease inhibitor that inhibits both tissue-type and urokinase-type plasminogen activators. Expression of PAI-1 is regulated by growth factors, cytokines, and hormones...
  54. ncbi Cloning and sequencing of cDNA for the rat plasminogen activator inhibitor-1
    R Zeheb
    Department of Human Genetics, University of Michigan Medical School, Ann Arbor 48109 0618
    Gene 73:459-68. 1988
    A cDNA encoding rat plasminogen activator-inhibitor (PAI-1) has been isolated from an HTC rat hepatoma cell cDNA library constructed in phage lambda gt10...
  55. ncbi The 4G/5G genetic polymorphism in the promoter of the plasminogen activator inhibitor-1 (PAI-1) gene is associated with differences in plasma PAI-1 activity but not with risk of myocardial infarction in the ECTIM study. Etude CasTemoins de I'nfarctus du M
    S Ye
    Department of Medicine, University College London Medical School, UK
    Thromb Haemost 74:837-41. 1995
    We have investigated the interrelationships of plasma PAI-1 activity, the PAI-1 4G/5G polymorphism and risk of myocardial infarction (MI) in the ECTIM study, a case-control study of MI based in Belfast, Lille, Strasbourg and Toulouse...
  56. ncbi Inactivation of plasminogen activator inhibitor-1 accelerates thrombolysis of a platelet-rich thrombus in rat mesenteric arterioles
    A Rupin
    Division of Angiology, Servier Research Institute, Suresnes, France
    Thromb Haemost 86:1528-31. 2001
    To investigate the role of active plasminogen activator inhibitor 1 (PAI-1) in the evolution of a microthrombus generated in the arteriolar microcirculation, the monoclonal antibody, 33H1F7, which transforms active PAI-1 to a tissue type ..
  57. ncbi The hexosamine pathway regulates the plasminogen activator inhibitor-1 gene promoter and Sp1 transcriptional activation through protein kinase C-beta I and -delta
    Howard J Goldberg
    Department of Medicine, Mount Sinai Hospital and University Health Network, 600 University Avenue, Suite 780, Toronto, Ontario M5G 1X5, Canada
    J Biol Chem 277:33833-41. 2002
    ..cells that both high glucose concentrations and glucosamine activated the plasminogen activator inhibitor-1 (PAI-1) gene promoter through the transcription factor, Sp1; and that the glutamine:fructose-6-phosphate ..
  58. ncbi Regulation of plasminogen activator inhibitor-1 secretion by growth factors in smooth muscle cells
    H K F Lau
    Division of Hematology, Department of Medicine, St Michael s and University of Toronto, Ontario, Canada
    Blood Coagul Fibrinolysis 13:541-9. 2002
    ..bFGF) and platelet-derived growth factor (PDGF) could dose-dependently induce plasminogen activator inhibitor-1 (PAI-1) secretion from these cells...
  59. ncbi Hypoxia-inducible factor-1 and hypoxia response elements mediate the induction of plasminogen activator inhibitor-1 gene expression by insulin in primary rat hepatocytes
    Thomas Kietzmann
    Institut fur Biochemie und Molekulare Zellbiologie, Gottingen, Germany
    Blood 101:907-14. 2003
    The expression of the plasminogen activator inhibitor-1 (PAI-1) gene is enhanced by insulin both in vivo and in various cell types...
  60. ncbi [A novel function of anti-fibrinolytic factor, PAI-1, in the central nervous system: a possible role as the neurotrophic factor]
    Takuya Imatoh
    Department of Biochemistry, Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka 814 0180, Japan
    Nihon Yakurigaku Zasshi 120:64P-66P. 2002
    Plasminogen activator inhibitor-1 (PAI-1) is a serpin that suppresses fibrinolysis by inhibiting the activity of plasminogen activator (PA)...
  61. ncbi The serpin protease-nexin 1 is present in rat aortic smooth muscle cells and is upregulated in L-NAME hypertensive rats
    Marie Christine Bouton
    Equipe INSERM E9907 and Unité INSERM U460, Faculte Xavier Bichat, Paris, France
    Arterioscler Thromb Vasc Biol 23:142-7. 2003
    ..In this study, we examined the expression of functionally active PN-1 in vitro in rat aortic smooth muscle cells and in vivo in rat arterial media and its regulation in hypertensive rats...
  62. pmc A plasminogen activator inhibitor-1 promoter polymorphism and idiopathic interstitial pneumonia
    Kevin K Kim
    Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan School of Medicine, Ann Arbor, MI 48109 0642, USA
    Mol Med 9:52-6. 2003
    ..is suppressed in fibrotic lung diseases in part because of increased levels of plasminogen activator inhibitor-1 (PAI-1)...
  63. ncbi Circadian gene expression of clock genes and plasminogen activator inhibitor-1 in heart and aorta of spontaneously hypertensive and Wistar-Kyoto rats
    Yoshiro Naito
    Department of Internal Medicine, Cardiovascular Division, Hyogo College of Medicine, Nishinomiya, Japan
    J Hypertens 21:1107-15. 2003
    ..Plasminogen activator inhibitor-1 (PAI-1) expression is directly regulated by clock genes, while angiotensin II modulates both PAI-1 and clock gene ..
  64. ncbi Temporal profile of tissue plasminogen activator (tPA) and inhibitor expression after transient focal cerebral ischemia
    Gang Zhao
    Department of Pediatrics, Queen s University, Rm 6 303, Doran 3, Kingston General Hospital, Kingston, Ontario K7L 2V7, Canada
    Neuroreport 14:1689-92. 2003
    ..We determined the changes in tPA and plasminogen activator inhibitor (PAI-1) expression in adult rat brain after transient middle cerebral artery (MCA) occlusion...
  65. ncbi Cellular carbonyl stress enhances the expression of plasminogen activator inhibitor-1 in rat white adipocytes via reactive oxygen species-dependent pathway
    Yoko Uchida
    Department of Pharmacology, Tokyo Women s Medical University, School of Medicine, 8 1 Kawada cho, Shinjuku ku, Tokyo 162 8666, Japan
    J Biol Chem 279:4075-83. 2004
    ..In the present study, we observed that the plasminogen activator inhibitor-1 (PAI-1) levels in serum and its gene expression in adipose tissue were up-regulated in aged OLETF rats, model animals of ..
  66. ncbi The PAI-1 gene 4G/5G polymorphism and deep vein thrombosis in patients with inherited thrombophilia
    Maria Teresa Sartori
    Department of Medical and Surgical Sciences, University of Padua Medical School, Padua, Italy
    Clin Appl Thromb Hemost 9:299-307. 2003
    ..Hypofibrinolysis due to excess PAI-1 can be found in patients with deep vein thrombosis (DVT) and 4G/5G polymorphism of the PAI-1 gene may modulate ..
  67. ncbi Genetic polymorphisms associated with thrombophilia and vascular disease in women with unexplained late intrauterine fetal death: a multicenter study
    Lukas Hefler
    Department of Obstetrics and Gynecology, Vienna University Medical School, Vienna, Austria
    J Soc Gynecol Investig 11:42-4. 2004
    ..We determined whether gene polymorphisms associated with thrombophilia and vascular disease as etiologic factors were involved in the pathogenesis of pregnancy-associated complications...
  68. ncbi PAI-1 expression is required for epithelial cell migration in two distinct phases of in vitro wound repair
    Kirwin M Providence
    Center for Cell Biology and Cancer Research, Albany Medical College, Albany, New York 12208, USA
    J Cell Physiol 200:297-308. 2004
    ..Expression of plasminogen activator inhibitor type-1 (PAI-1), a serine protease inhibitor (SERPIN) important in the control of barrier proteolysis and cell-to-matrix ..
  69. ncbi Renal synthesis of urokinase type-plasminogen activator, its receptor, and plasminogen activator inhibitor-1 in diabetic nephropathy in rats: modulation by angiotensin-converting-enzyme inhibitor
    Miyazaki Kenichi
    The Department of Histology and Cell Biology, Nagasaki University School of Medicine, Nagasaki, Japan
    J Lab Clin Med 144:69-77. 2004
    ..In the study reported here we examined the expression of plasminogen-activator inhibitor-1 (PAI-1), urokinase-type plasminogen activator (uPA), and uPA receptor (uPAR), as well as the relevance of such ..
  70. ncbi Regression of glomerulosclerosis with high-dose angiotensin inhibition is linked to decreased plasminogen activator inhibitor-1
    Li Jun Ma
    Department of Pathology, Vanderbilt University Medical Center, 21st and Garland Avenue, Nashville, TN 37232 2561, USA
    J Am Soc Nephrol 16:966-76. 2005
    ..It is concluded that angiotensin inhibition mediates regression in part by effects on matrix modulation...
  71. ncbi Role of c-Jun NH2-terminal kinase in G-protein-coupled receptor agonist-induced cardiac plasminogen activator inhibitor-1 expression
    Takashi Omura
    Department of Internal Medicine and Cardiology, Osaka City University Medical School, 1 4 3 Asahi machi, Abeno Ku, Osaka 545 8585, Japan
    J Mol Cell Cardiol 38:583-92. 2005
    Plasminogen activator inhibitor-1 (PAI-1) has been implicated as a contributing risk factor for cardiovascular disease. However, little is known about molecular mechanisms of cardiac PAI-1 gene expression...
  72. pmc Dual role for plasminogen activator inhibitor type 1 as soluble and as matricellular regulator of epithelial alveolar cell wound healing
    François Maquerlot
    Informatique, Biologie Intégrative et Systèmes Complexes, FRE 2873 Centre National de la Recherche Scientifique, Université d Evry, Genopole, Evry, France
    Am J Pathol 169:1624-32. 2006
    ..In addition, the complex formed by uPAR-uPA and matrix-bound plasminogen activator inhibitor type-1 (PAI-1) exerts nonproteolytic roles in various cell types...
  73. ncbi Urokinase plasminogen activator and plasminogen activator inhibitor type-1 in nonsmall-cell lung cancer: relation to prognosis and angiogenesis
    Birgitte Vrou Offersen
    Department of Experimental Clinical Oncology, Aarhus University Hospital, Nørrebrogade 44, Bld 5, DK 8000 Aarhus C, Denmark
    Lung Cancer 56:43-50. 2007
    Urokinase plasminogen activator (uPA) and plasminogen activator inhibitor type-1 (PAI-1) have previously been suggested as prognostic markers in nonsmall-cell lung carcinomas (NSCLC)...
  74. ncbi Aldosterone up-regulates production of plasminogen activator inhibitor-1 by renal mesangial cells
    Jun Yuan
    Department of Nephrology, Renmin Hospital of Wuhan University, Wuhan, China
    J Biochem Mol Biol 40:180-8. 2007
    ..II (Ang II) did, by inducing cultured renal mesangial cells to produce plasminogen activator inhibitor-1 (PAI-1), and whether these effects were mediated by aldosterone-induced increase in transforming growth factor beta(1) (..
  75. ncbi Renin-stimulated TGF-beta1 expression is regulated by a mitogen-activated protein kinase in mesangial cells
    Y Huang
    Division of Nephrology, Fibrosis Research Laboratory, University of Utah, Salt Lake City, Utah 84108, USA
    Kidney Int 72:45-52. 2007
    ..This renin-activated pathway triggers cell proliferation along with TGF-beta1 and plasminogen activator inhibitor-1 gene expression. This system may play an important role in the overall profibrotic actions of renin...
  76. pmc Glucocorticoids activate TGF-beta induced PAI-1 and CTGF expression in rat hepatocytes
    Lucia Wickert
    Institute of Clinical Chemistry and Pathobiochemistry, University Hospital RWTH Aachen, Pauwelsstr, 30, D 52074 Aachen, Germany
    Comp Hepatol 6:5. 2007
    ..In non-parenchymal cells, TGF-beta induces plasminogen activator inhibitor 1 (PAI-1) and connective tissue growth factor (CTGF) expression, which are involved in extra cellular ..
  77. ncbi [Effects of losartan on expressions of plasminogen activator and plasminogen activator inhibitor-1 of rat proximal tubular epithelial cells cultured with high glucose]
    Li Jun Pu
    Department of Nephrology, West China Hospital, Sichuan University, Chengdu 610041, China
    Sichuan Da Xue Xue Bao Yi Xue Ban 38:813-5. 2007
    To investigate the effects of high glucose on expressions of plasminogen activator (PA) and plasminogen activator inhibitor-1 (PAI-1) of rat proximal tubular epithelial cells, and the role of angiotensin II receptor antagonist Losartan.
  78. doi Inhibition of plasminogen activator inhibitor-1: its mechanism and effectiveness on coagulation and fibrosis
    Yuko Izuhara
    Institute of Medical Sciences, Tokai University, Kanagawa, Japan
    Arterioscler Thromb Vasc Biol 28:672-7. 2008
    ..For the first time, we apply a new approach of virtual screening to discover novel, orally active, small molecule serpin inhibitors and report their effectiveness...
  79. doi Plasminogen activator inhibitor-1 in obstructive sleep apnea patients with and without hypertension
    Carlos Zamarron
    Division of Respiratory Medicine, Hospital Clinico Universitario de Santiago, Choupana s n, Santiago de Compostela 15706, Spain
    Lung 186:151-6. 2008
    ..To test the presence of decreased fibrinolysis, we measured plasma levels of plasminogen activator inhibitor-1 (PAI-1) in 96 male subjects (32 subjects with OSAS, 32 subjects with both OSAS and hypertension, and a 32 subjects in ..
  80. doi Plasminogen activator inhibitor type 1 inhibits smooth muscle cell proliferation in pulmonary arterial hypertension
    Fotini M Kouri
    Department of Medicine II, University of Giessen Lung Center UGLC, Justus Liebig University, Giessen, Germany
    Int J Biochem Cell Biol 40:1872-82. 2008
    ..In this study, we investigated the expression and function of plasminogen activator inhibitor (PAI)-1, an inhibitor of the plasminogen activator system and target gene of the transforming growth factor (TGF)-beta1 ..
  81. doi Aldosterone and TGF-beta1 synergistically increase PAI-1 and decrease matrix degradation in rat renal mesangial and fibroblast cells
    Wei Huang
    Fibrosis Research Laboratory, Division of Nephrology, University of Utah School of Medicine, Salt Lake City, UT 84108, USA
    Am J Physiol Renal Physiol 294:F1287-95. 2008
    ..is thought to modulate renal fibrosis, in part, through increasing plasminogen activator inhibitor type 1 (PAI-1), a major inhibitor of ECM degradation...
  82. doi [Effects of Dahuang Zhechong Pill on expressions of tissue inhibitor of metalloproteinase-1 and plasminogen activator inhibitor-1 in rats with glomerulosclerosis]
    Ji Hong Chen
    Department of Nephrology, National Medical Centre for Traditional Chinese Medicine Nephropathy, Jiangsu Provincial Hospital of Traditional Chinese Medicine, Nanjing, Jiangsu Province 210029, China
    Zhong Xi Yi Jie He Xue Bao 6:512-6. 2008
    ..renal disease, and to investigate the effects of DHZCP on the expressions of renal tissue inhibitor of metalloproteinase-1 (TIMP-1) and plasminogen activator inhibitor-1 (PAI-1) mRNAs in rats with adriamycin-induced glomerulosclerosis.
  83. doi Plasmin system regulation in an ovalbumin-induced rat model of asthma
    I Kucharewicz
    Department of Allergology and Internal Medicine, Medical University of Bialystok, Bialystok, Poland
    Int Arch Allergy Immunol 147:190-6. 2008
    ..So far studies showing the role of the plasmin system in airway remodelling have been conducted using in vitro models. The aim of the present study was to determine plasmin system regulation in an in vivo rat model of asthma...
  84. pmc Shear stress-induced Ets-1 modulates protease inhibitor expression in microvascular endothelial cells
    Malgorzata Milkiewicz
    School of Kinesiology and Health Science, York University, Toronto, Ontario, Canada
    J Cell Physiol 217:502-10. 2008
    ..This response was modulated by ERK1/2 and p38 MAP kinases, but was not dependent on NOS or COX-2 activity. PAI-1, TIMP-1 and TIMP-3 mRNA were elevated significantly in prazosin treated EDL, and in response to shear stimulation ..
  85. doi Differential control of MMP and t-PA/PAI-1 expressions by sympathetic and renin-angiotensin systems in rat left ventricle
    Houcine Dab
    Unité de Physiologie Intégrée, Laboratoire de Pathologies Vasculaires, Faculte des Sciences de Bizerte, Tunisia
    Auton Neurosci 150:27-32. 2009
    ..The mRNA of the plasminogen activator (t-PA) and its inhibitor (PAI-1), the mRNA, protein and activity of the matrix metalloproteinases MMP-2 and MMP-9 were examined by Q-RT-PCR, ..
  86. pmc Plasminogen activator inhibitor type 1 up-regulation is associated with skeletal muscle atrophy and associated fibrosis
    Jasmin Naderi
    Institute of Neuropathology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Am J Pathol 175:763-71. 2009
    ..In contrast, transcript levels of plasminogen activator inhibitor type 1 (PAI-1) was dramatically increased in atrophic myotubes and microgravity-exposed rat gastrocnemius muscle, while ..
  87. pmc Recombinant plasminogen activator inhibitor-1 inhibits intimal hyperplasia
    Jianbo Wu
    Department of Internal Medicine, University of Missouri School of Medicine, and Research Service, Harry S Truman Memorial Veterans Affairs Hospital, Columbia, MO 65212, USA
    Arterioscler Thromb Vasc Biol 29:1565-70. 2009
    Plasminogen activator inhibitor-1 (PAI-1) overexpression is implicated in vascular disease. However, the effects of a primary increase in PAI-1 expression on arterial remodeling are poorly defined...
  88. pmc Therapeutic administration of plasminogen activator inhibitor-1 prevents hypoxic-ischemic brain injury in newborns
    Dianer Yang
    Division of Developmental Biology and Division of Neurology, Department of Radiology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    J Neurosci 29:8669-74. 2009
    ..we examined the therapeutic effect of intracerebroventricular injection of plasminogen activator inhibitor-1 (PAI-1) in rat pups subjected to unilateral carotid artery occlusion and systemic hypoxia...
  89. doi Plasminogen activator inhibitor type-1 gene 4G/5G polymorphism in Turkish adult patients with asthma
    Didem Cosan
    Department of Medical Biology, Medical Faculty, Eskisehir Osmangazi University, Eskisehir, Turkey
    Genet Test Mol Biomarkers 13:543-6. 2009
    ....
  90. pmc Mechanisms underlying the antifibrotic properties of noninhibitory PAI-1 (PAI-1R) in experimental nephritis
    Yufeng Huang
    Fibrosis Research Laboratory, Division of Nephrology, University of Utah School of Medicine, Salt Lake City, UT 84108, USA
    Am J Physiol Renal Physiol 297:F1045-54. 2009
    Administration of a mutant, noninhibitory PAI-1 (PAI-1R), reduces disease in experimental glomerulonephritis...
  91. doi Coagulation factors in the airways in moderate and severe asthma and the effect of inhaled steroids
    F J H Brims
    Respiratory Centre, Queen Alexandra Hospital, Portsmouth Hospitals NHS Trust, UK
    Thorax 64:1037-43. 2009
    ....
  92. pmc Prevalence and significance of coagulation abnormalities in community-acquired pneumonia
    Eric B Milbrandt
    The CRISMA Clinical Research, Investigation, and Systems Modeling of Acute Illness Laboratory, Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    Mol Med 15:438-45. 2009
    ..We measured plasma coagulation markers (D-dimer, plasminogen activator inhibitor [PAI], antithrombin, factor IX, and thrombin-antithrombin complex [TAT]) at the time of patient presentation to the ..
  93. doi Tissue-specific PAI-1 gene expression and glycosylation pattern in insulin-resistant old rats
    R Serrano
    Atherothrombosis Research, Centre for Applied Medical Research, University of Navarra, Pamplona, Spain
    Am J Physiol Regul Integr Comp Physiol 297:R1563-9. 2009
    Increased levels of plasminogen activator inhibitor-1 (PAI-1) have been associated with obesity, aging, insulin resistance, and type 2 diabetes, conditions that contribute to increased cardiovascular risk...
  94. pmc Elevated PAI-1 is associated with poor clinical outcomes in pediatric patients with acute lung injury
    Anil Sapru
    Division of Critical Care Medicine, Department of Pediatrics, University of California, San Francisco, Box 0106, San Francisco, CA 94143, USA
    Intensive Care Med 36:157-63. 2010
    ..Plasminogen activator inhibitor-1 (PAI-1) is an antifibrinolytic agent that is activated during inflammation...
  95. pmc Orphan nuclear receptor small heterodimer partner inhibits angiotensin II- stimulated PAI-1 expression in vascular smooth muscle cells
    Kyeong Min Lee
    Department of Internal Medicine, Kyungpook National University School of Medicine, Daegu, Korea
    Exp Mol Med 42:21-9. 2010
    ..proliferation and extracellular matrix accumulation through the upregulation of plasminogen activator inhibitor-1 (PAI-1) expression...
  96. pmc SPARC suppresses apoptosis of idiopathic pulmonary fibrosis fibroblasts through constitutive activation of beta-catenin
    Wenteh Chang
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, Stanford University Medical Center, Stanford, California 94305 5236, USA
    J Biol Chem 285:8196-206. 2010
    ..that IPF fibroblasts constitutively expressed increased basal levels of SPARC, plasminogen activator inhibitor-1 (PAI-1), and active beta-catenin compared with control cells...
  97. doi Effects of activated protein C on ventilator-induced lung injury in rats
    Jiunn Song Jiang
    Department of Internal Medicine, Shin Kong Wu Ho Su Memorial Hospital and School of Respiratory Therapy, Taipei, Taiwan, ROC
    Respiration 80:246-53. 2010
    Mechanical ventilation with a high tidal volume (VT) increases lung and systemic plasminogen activator inhibitor (PAI)-1 levels and alveolar fibrin deposition...
  98. pmc Sleep-disordered breathing and prothrombotic biomarkers: cross-sectional results of the Cleveland Family Study
    Reena Mehra
    Department of Medicine, Case Comprehensive Cancer Center, Case School of Medicine, Cleveland, Ohio, USA
    Am J Respir Crit Care Med 182:826-33. 2010
    ..Individuals with sleep-disordered breathing (SDB) are at increased cardiovascular risk, possibly due to SDB-related stresses contributing to atherosclerosis...

Research Grants5

  1. Symposium on Retinal/ Choroidal Angiogenesis
    John Penn; Fiscal Year: 2004
    ..J. Donald M. Gass, M.D. has agreed to write an introduction. In this application we request funds to support travel and registration costs of 20 young investigators and 2 keynote speakers. ..
  2. Bradykinin Receptor Antagonism During Cardiopulmonary Bypass
    Mias Pretorius; Fiscal Year: 2010
    ..These studies promise to provide important information regarding the effects of drugs that interrupt the RAS and generate new strategies to reduce morbidity in patients undergoing CPB. ..
  3. Alveolar Epithelium in Acute Lung Injury
    Lorraine Ware; Fiscal Year: 2005
    ..Combined with a compelling research project, the training will -provide the skills necessary for a successful career in biomedical research. ..
  4. Phenotype-Genotype Interactions and Type 2 Diabetes
    James Meigs; Fiscal Year: 2005
    ..Results will provide a foundation for future laboratory efforts and will increase understanding of phenotype-genotype interactions in diabetes pathogenesis. ..
  5. Biomarker Profiles in the Diagnosis/Prognosis of ARDS
    Lorraine Ware; Fiscal Year: 2008
    ..unreadable] [unreadable]..