Rps6

Summary

Gene Symbol: Rps6
Description: ribosomal protein S6
Alias: 40S ribosomal protein S6
Species: rat

Top Publications

  1. ncbi Continuous ethanol exposure inhibits agonist-stimulated phosphorylation of p70S6 kinase and ribosomal S6 protein in cultured rat astrocytes
    Thomas L Smith
    Research Health Care Group 0 151, Southern Arizona VA Health Care System, Tucson, AZ, USA
    Brain Res Mol Brain Res 131:145-8. 2004
  2. ncbi Effects of contraction and insulin on protein synthesis, AMP-activated protein kinase and phosphorylation state of translation factors in rat skeletal muscle
    Lisa Miranda
    Hormone and Metabolic Research Unit, de Duve Institute, Universite Catholique de Louvain, Avenue Hippocrate, 75, 1200 Brussels, Belgium
    Pflugers Arch 455:1129-40. 2008
  3. pmc rpS6 regulates blood-testis barrier dynamics through Akt-mediated effects on MMP-9
    Ka Wai Mok
    The Mary M Wohlford Laboratory for Male Contraceptive Research, Center for Biomedical Research, Population Council, 1230 York Avenue, New York, NY 10065, USA
    J Cell Sci 127:4870-82. 2014
  4. pmc Roles of Sestrin2 and Ribosomal Protein S6 in Transient Global Ischemia-Induced Hippocampal Neuronal Injury
    Yao Chung Chuang
    Department of Neurology, Kaohsiung Chang Gung Memorial Hospital, College of Medicine, Chang Gung University, Kaohsiung 833, Taiwan
    Int J Mol Sci 16:26406-16. 2015
  5. pmc Striatal cholinergic interneurons display activity-related phosphorylation of ribosomal protein S6
    Jesus Bertran-Gonzalez
    Behavioural Neuroscience Laboratory, Brain and Mind Research Institute, The University of Sydney, New South Wales, Australia
    PLoS ONE 7:e53195. 2012
  6. pmc rpS6 Regulates blood-testis barrier dynamics by affecting F-actin organization and protein recruitment
    Ka Wai Mok
    Center for Biomedical Research, Population Council, New York, New York 10065, USA
    Endocrinology 153:5036-48. 2012
  7. ncbi The isolation of eukaryotic ribosomal proteins. The purification and characterization of the 40 S ribosomal subunit proteins S2, S3, S4, S5, S6, S7, S8, S9, S13, S23/S24, S27, and S28
    E Collatz
    J Biol Chem 251:4666-72. 1976
  8. ncbi Hormonally inducible phosphorylation of a nuclear pool of ribosomal protein S6
    R Franco
    Eukaryotic Regulatory Biology Program, University of California, San Diego School of Medicine, La Jolla 92093
    J Biol Chem 265:4321-5. 1990
  9. ncbi The primary structure of rat ribosomal protein S6
    Y L Chan
    Department of Biochemistry and Molecular Biology, University of Chicago, Illinois 60637
    J Biol Chem 263:2891-6. 1988
  10. ncbi Ribosomal proteins S2, S6, S10, S14, S15 and S25 are localized on the surface of mammalian 40 S subunits and stabilize their conformation. A study with immobilized trypsin
    M J Marion
    Laboratoire de Biologie et Technologie des Membranes, CNRS UM 24, Université Claude Bernard de Lyon, Villeurbanne, France
    FEBS Lett 232:281-5. 1988

Scientific Experts

  • Thomas L Smith
  • Jenq Lin Yang
  • Ka Wai Mok
  • Yao Chung Chuang
  • C Yan Cheng
  • Dolores D Mruk
  • Jesus Bertran-Gonzalez
  • Lisa Miranda
  • F Kawano
  • Peter M Mourani
  • O Jameel Shah
  • Chia Wei Liou
  • Ding I Yang
  • Shang Der Chen
  • Tsu Kung Lin
  • Bruno Silvestrini
  • Vincent Laurent
  • Bernard W Balleine
  • Emmanuel Valjent
  • Billy C Chieng
  • Sandrine Horman
  • Isabelle De Potter
  • Mark H Rider
  • Louis Hue
  • Jørgen Jensen
  • Y Matsuoka
  • N Nakai
  • M Terada
  • Y Oke
  • S Imajoh-Ohmi
  • Y Ohira
  • X D Wang
  • H Fukuda
  • Y Higo
  • Pamela J Garl
  • Todd C Carpenter
  • Janet M Wenzlau
  • Kurt R Stenmark
  • Tony Hunter
  • Mary C M Weiser-Evans
  • F Lecomte
  • J Szpirer
  • J F Dasnoy
  • C Szpirer
  • B Champagne
  • E Collatz
  • R Franco
  • G Lutsch
  • M J Marion
  • Y L Chan
  • I G Wool
  • C Marion
  • F Noll
  • M G Rosenfeld
  • G Enzmann
  • H Bielka
  • G Stoffler
  • A Lin

Detail Information

Publications16

  1. ncbi Continuous ethanol exposure inhibits agonist-stimulated phosphorylation of p70S6 kinase and ribosomal S6 protein in cultured rat astrocytes
    Thomas L Smith
    Research Health Care Group 0 151, Southern Arizona VA Health Care System, Tucson, AZ, USA
    Brain Res Mol Brain Res 131:145-8. 2004
    ..In contrast, ethanol exposure had no effect on the protein expression of either p70S6 kinase or S6 protein. Our data suggest that continuous ethanol exposure results in a generalized decrease in agonist-activation of the p70S6 pathway...
  2. ncbi Effects of contraction and insulin on protein synthesis, AMP-activated protein kinase and phosphorylation state of translation factors in rat skeletal muscle
    Lisa Miranda
    Hormone and Metabolic Research Unit, de Duve Institute, Universite Catholique de Louvain, Avenue Hippocrate, 75, 1200 Brussels, Belgium
    Pflugers Arch 455:1129-40. 2008
    ..stimulated protein synthesis (by 30%) and increased p70 ribosomal protein S6 kinase (p70S6K) Thr389, 40S ribosomal protein S6 (rpS6) Ser235/236, rpS6 Ser240/244 and eukaryotic initiation factor-4E-binding protein-1 (4E-BP1) Thr37/..
  3. pmc rpS6 regulates blood-testis barrier dynamics through Akt-mediated effects on MMP-9
    Ka Wai Mok
    The Mary M Wohlford Laboratory for Male Contraceptive Research, Center for Biomedical Research, Population Council, 1230 York Avenue, New York, NY 10065, USA
    J Cell Sci 127:4870-82. 2014
    ..rapamycin complex 1 (mTORC1) is an emerging regulator of blood-tissue barriers that utilizes ribosomal protein S6 (rpS6) as the downstream signaling molecule...
  4. pmc Roles of Sestrin2 and Ribosomal Protein S6 in Transient Global Ischemia-Induced Hippocampal Neuronal Injury
    Yao Chung Chuang
    Department of Neurology, Kaohsiung Chang Gung Memorial Hospital, College of Medicine, Chang Gung University, Kaohsiung 833, Taiwan
    Int J Mol Sci 16:26406-16. 2015
    ..In addition, sestrin2 may also regulate ribosomal protein S6 (RpS6), a molecule important for protein synthesis, through the effect of mammalian target of rapamycin (mTOR) complex ..
  5. pmc Striatal cholinergic interneurons display activity-related phosphorylation of ribosomal protein S6
    Jesus Bertran-Gonzalez
    Behavioural Neuroscience Laboratory, Brain and Mind Research Institute, The University of Sydney, New South Wales, Australia
    PLoS ONE 7:e53195. 2012
    ....
  6. pmc rpS6 Regulates blood-testis barrier dynamics by affecting F-actin organization and protein recruitment
    Ka Wai Mok
    Center for Biomedical Research, Population Council, New York, New York 10065, USA
    Endocrinology 153:5036-48. 2012
    ..Herein, we provide evidence that ribosomal protein S6 (rpS6), the downstream signaling molecule of the mammalian target of rapamycin complex 1 (mTORC1) pathway, is a major ..
  7. ncbi The isolation of eukaryotic ribosomal proteins. The purification and characterization of the 40 S ribosomal subunit proteins S2, S3, S4, S5, S6, S7, S8, S9, S13, S23/S24, S27, and S28
    E Collatz
    J Biol Chem 251:4666-72. 1976
    ..The molecular weight of the proteins was estimated by polyazrylamide gel electrophoresis in sodium dodecyl sulfate; the amino acid composition was determined...
  8. ncbi Hormonally inducible phosphorylation of a nuclear pool of ribosomal protein S6
    R Franco
    Eukaryotic Regulatory Biology Program, University of California, San Diego School of Medicine, La Jolla 92093
    J Biol Chem 265:4321-5. 1990
    ..Our experimental data indicate the existence of a nuclear pool of S6 whose phosphorylation is hormone inducible...
  9. ncbi The primary structure of rat ribosomal protein S6
    Y L Chan
    Department of Biochemistry and Molecular Biology, University of Chicago, Illinois 60637
    J Biol Chem 263:2891-6. 1988
    ..Rat S6 is homologous to Saccharomyces cerevisiae S10 (the extent of the identity is 75%) and most likely also to Schizosaccharomyces pombe S6...
  10. ncbi Ribosomal proteins S2, S6, S10, S14, S15 and S25 are localized on the surface of mammalian 40 S subunits and stabilize their conformation. A study with immobilized trypsin
    M J Marion
    Laboratoire de Biologie et Technologie des Membranes, CNRS UM 24, Université Claude Bernard de Lyon, Villeurbanne, France
    FEBS Lett 232:281-5. 1988
    ....
  11. ncbi Electron microscopic investigations on the location of rat liver ribosomal proteins S3a, S5, S6, S7 and S9 by means of antibody labeling
    G Lutsch
    Biomed Biochim Acta 42:705-23. 1983
    ..Protein S5 could be localized in the head and protein S9 in the body of the 40S subunits. These findings are discussed with regard to the location of functional sites on the 40S ribosomal subunit...
  12. ncbi The mammalian RPS6 gene, homolog of the Drosophila air8 tumor suppressor gene: is it an oncosuppressor gene?
    F Lecomte
    Universite Libre de Bruxelles, Departement de Biologie Moleculaire, Rhode Saint Genese, Belgium
    Somat Cell Mol Genet 21:443-50. 1995
    ..We assigned the rat Rps6 gene to chromosome 5q22-33...
  13. ncbi Unique, highly proliferative growth phenotype expressed by embryonic and neointimal smooth muscle cells is driven by constitutive Akt, mTOR, and p70S6K signaling and is actively repressed by PTEN
    Peter M Mourani
    Department of Pediatrics, University of Colorado Health Sciences Center, Denver, Colo 80262, USA
    Circulation 109:1299-306. 2004
    ..The aim of the present study was to evaluate the functional role of S6 ribosomal protein (S6RP) and upstream positive and negative regulators in the control of SMC serum-independent growth...
  14. ncbi Critical role of T-loop and H-motif phosphorylation in the regulation of S6 kinase 1 by the tuberous sclerosis complex
    O Jameel Shah
    Molecular and Cellular Biology Laboratory, The Salk Institute for Biological Studies, 10010 N Torrey Pines Road, La Jolla, CA 92037, USA
    J Biol Chem 279:20816-23. 2004
    ..These results also highlight the importance of dual control of T-loop and H-motif phosphorylation of S6K1 by the Tsc1-Tsc2 complex...
  15. ncbi Role(s) of nucleoli and phosphorylation of ribosomal protein S6 and/or HSP27 in the regulation of muscle mass
    F Kawano
    Graduate School of Medicine, Osaka University, Suita City, Osaka, Japan
    Am J Physiol Cell Physiol 293:C35-44. 2007
    ..It was also indicated that such regulation was not necessarily associated with the neural activity...