Rims1

Summary

Gene Symbol: Rims1
Description: regulating synaptic membrane exocytosis 1
Alias: RIM1a, Rim1, regulating synaptic membrane exocytosis protein 1, RIM 1, Rab3 effector, Rim1b protein, rab-3-interacting molecule 1, rab3-interacting molecule 1
Species: rat

Top Publications

  1. ncbi The RIM/NIM family of neuronal C2 domain proteins. Interactions with Rab3 and a new class of Src homology 3 domain proteins
    Y Wang
    Center for Basic Neuroscience, Department of Molecular Genetics and Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, Texas 75235 9111, USA
    J Biol Chem 275:20033-44. 2000
  2. ncbi Functional interaction of the active zone proteins Munc13-1 and RIM1 in synaptic vesicle priming
    A Betz
    Max Planck Institut, für experimentelle Medizin, Abteilung Neurogenetik, AG Molekulare Neurobiologie, Hermann Rein Str 3, D 37075, Gottingen, Germany
    Neuron 30:183-96. 2001
  3. pmc Cast: a novel protein of the cytomatrix at the active zone of synapses that forms a ternary complex with RIM1 and munc13-1
    Toshihisa Ohtsuka
    KAN Research Institute Inc, Kyoto 600 8815, Japan
    J Cell Biol 158:577-90. 2002
  4. pmc A family of RIM-binding proteins regulated by alternative splicing: Implications for the genesis of synaptic active zones
    Yun Wang
    The Center for Basic Neuroscience and Department of Molecular Genetics, Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390 9111, USA
    Proc Natl Acad Sci U S A 99:14464-9. 2002
  5. ncbi Rim is a putative Rab3 effector in regulating synaptic-vesicle fusion
    Y Wang
    Department of Molecular Genetics, The University of Texas, Southwestern Medical Center at Dallas, 75235, USA
    Nature 388:593-8. 1997
  6. pmc RIM proteins activate vesicle priming by reversing autoinhibitory homodimerization of Munc13
    Lunbin Deng
    Department of Molecular and Cellular Physiology, Stanford University, Lorry Lokey Building, 265 Campus Drive, Stanford, CA 94305 5453, USA
    Neuron 69:317-31. 2011
  7. pmc RIM proteins tether Ca2+ channels to presynaptic active zones via a direct PDZ-domain interaction
    Pascal S Kaeser
    Department of Molecular and Cellular Physiology, Stanford University, Stanford, CA 94305 5453, USA
    Cell 144:282-95. 2011
  8. ncbi Direct interaction of the Rab3 effector RIM with Ca2+ channels, SNAP-25, and synaptotagmin
    T Coppola
    Institut de Biologie Cellulaire et de Morphologie, University of Lausanne, 1005 Lausanne, Switzerland
    J Biol Chem 276:32756-62. 2001
  9. ncbi RIM1alpha forms a protein scaffold for regulating neurotransmitter release at the active zone
    Susanne Schoch
    The Center for Basic Neuroscience and Department of Molecular Genetics, Howard Hughes Medical Institute, The University of Texas Southwestern Medical Center, Dallas, Texas 75390 9111, USA
    Nature 415:321-6. 2002
  10. pmc RIM1α SUMOylation is required for fast synaptic vesicle exocytosis
    Fatima Girach
    Department of Biochemistry, School of Medical Sciences, University Walk, University of Bristol, Bristol BS8 1TD, UK
    Cell Rep 5:1294-301. 2013

Scientific Experts

  • Toshihisa Ohtsuka
  • Thomas C Sudhof
  • Yun Wang
  • Pascal S Kaeser
  • Lunbin Deng
  • Josep Rizo
  • Eiji Inoue
  • Yoshimi Takai
  • Samantha A Spangler
  • Fatima Girach
  • Etsuko Takao-Rikitsu
  • Ying Yang
  • Christoph Limbach
  • Xiaoping Jiang
  • Irina Dulubova
  • Y Wang
  • Rong Guan
  • Xinran Liu
  • Yaisa S Andrews-Zwilling
  • Ayuko Sakane
  • Jun Lu
  • Maki Deguchi-Tawarada
  • Sumiko Mochida
  • Marie Inoue
  • Fatma Simsek-Duran
  • Lei Sun
  • Susanne Schoch
  • Jeroen Demmers
  • Tim J Craig
  • Heidi de Wit
  • Ruud F Toonen
  • Casper C Hoogenraad
  • Josta T Kevenaar
  • Sabine K Schmitz
  • Jeremy M Henley
  • Daniel L Rocca
  • Esther de Graaff
  • A Betz
  • T Coppola
  • Wei Xu
  • Nadine Thiede
  • Michael M Laue
  • Xiaolu Wang
  • Greta Hultqvist
  • Nicole Calakos
  • Bin Hu
  • Manfred W Kilimann
  • Krista L Moulder
  • Patricia E Litkowski
  • Amanda A Taylor
  • Ying Lin
  • B Joy Snider
  • Diana R Tomchick
  • T C Sudhof
  • Han Dai
  • Mischa Machius
  • Kazunori Toida
  • Frederique Varoqueaux
  • Takuya Sasaki
  • Kerstin Reim
  • Jun Miyoshi
  • Hiroshi Kawabe
  • Hiroyoshi Ishizaki
  • Isao Kitajima
  • Hiroshi Takagi
  • Haruyuki Kamiya
  • Susumu Higa
  • Ikuko Yao
  • Emi Kiyokage
  • Mitsutoshi Setou
  • Miki Tanaka-Okamoto
  • Takayuki Yoshida
  • Nils Brose
  • Shinji Manabe
  • Kosei Takeuchi
  • Hongmei Li
  • GYORGY LONART
  • David J Linden
  • Mary A Bittner
  • Ronald W Holz
  • Tobias Jo
  • Martin Geppert
  • Thomas Biederer
  • Robert C Malenka
  • Konark Mukherjee
  • Frank Schmitz
  • Pablo E Castillo
  • U Ashery
  • H J Junge
  • V Perret-Menoud

Detail Information

Publications22

  1. ncbi The RIM/NIM family of neuronal C2 domain proteins. Interactions with Rab3 and a new class of Src homology 3 domain proteins
    Y Wang
    Center for Basic Neuroscience, Department of Molecular Genetics and Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, Texas 75235 9111, USA
    J Biol Chem 275:20033-44. 2000
    b>RIM1 is a putative effector protein for Rab3s, synaptic GTP-binding proteins. RIM1 is localized close to the active zone at the synapse, where it interacts in a GTP-dependent manner with Rab3 located on synaptic vesicles...
  2. ncbi Functional interaction of the active zone proteins Munc13-1 and RIM1 in synaptic vesicle priming
    A Betz
    Max Planck Institut, für experimentelle Medizin, Abteilung Neurogenetik, AG Molekulare Neurobiologie, Hermann Rein Str 3, D 37075, Gottingen, Germany
    Neuron 30:183-96. 2001
    ..We show that the active zone components Munc13-1, an essential vesicle priming protein, and RIM1, a Rab3 effector with a putative role in vesicle tethering, interact functionally...
  3. pmc Cast: a novel protein of the cytomatrix at the active zone of synapses that forms a ternary complex with RIM1 and munc13-1
    Toshihisa Ohtsuka
    KAN Research Institute Inc, Kyoto 600 8815, Japan
    J Cell Biol 158:577-90. 2002
    ..CAST was localized at the CAZ of conventional synapses of mouse brain. CAST bound directly RIM1 and indirectly Munc13-1, presumably through RIM1, forming a ternary complex...
  4. pmc A family of RIM-binding proteins regulated by alternative splicing: Implications for the genesis of synaptic active zones
    Yun Wang
    The Center for Basic Neuroscience and Department of Molecular Genetics, Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390 9111, USA
    Proc Natl Acad Sci U S A 99:14464-9. 2002
    ....
  5. ncbi Rim is a putative Rab3 effector in regulating synaptic-vesicle fusion
    Y Wang
    Department of Molecular Genetics, The University of Texas, Southwestern Medical Center at Dallas, 75235, USA
    Nature 388:593-8. 1997
    ..We propose that Rim serves as a Rab3-dependent regulator of synaptic-vesicle fusion by forming a GTP-dependent complex between synaptic plasma membranes and docked synaptic vesicles...
  6. pmc RIM proteins activate vesicle priming by reversing autoinhibitory homodimerization of Munc13
    Lunbin Deng
    Department of Molecular and Cellular Physiology, Stanford University, Lorry Lokey Building, 265 Campus Drive, Stanford, CA 94305 5453, USA
    Neuron 69:317-31. 2011
    ..Both mutant and wild-type Munc13, however, rescued priming in Munc13-deficient synapses. Thus, homodimerization of Munc13 inhibits its priming function, and RIMs activate priming by disrupting Munc13 homodimerization...
  7. pmc RIM proteins tether Ca2+ channels to presynaptic active zones via a direct PDZ-domain interaction
    Pascal S Kaeser
    Department of Molecular and Cellular Physiology, Stanford University, Stanford, CA 94305 5453, USA
    Cell 144:282-95. 2011
    ..We propose that RIMs tether N- and P/Q-type Ca(2+) channels to presynaptic active zones via a direct PDZ-domain-mediated interaction, thereby enabling fast, synchronous triggering of neurotransmitter release at a synapse...
  8. ncbi Direct interaction of the Rab3 effector RIM with Ca2+ channels, SNAP-25, and synaptotagmin
    T Coppola
    Institut de Biologie Cellulaire et de Morphologie, University of Lausanne, 1005 Lausanne, Switzerland
    J Biol Chem 276:32756-62. 2001
    ..We propose that the Rab3 effector RIM is a scaffold protein that participates through its multiple binding partners in the docking and fusion of ..
  9. ncbi RIM1alpha forms a protein scaffold for regulating neurotransmitter release at the active zone
    Susanne Schoch
    The Center for Basic Neuroscience and Department of Molecular Genetics, Howard Hughes Medical Institute, The University of Texas Southwestern Medical Center, Dallas, Texas 75390 9111, USA
    Nature 415:321-6. 2002
    ..These data indicate that RIM1alpha has a central function in integrating active zone proteins and synaptic vesicles into a molecular scaffold that controls neurotransmitter release...
  10. pmc RIM1α SUMOylation is required for fast synaptic vesicle exocytosis
    Fatima Girach
    Department of Biochemistry, School of Medical Sciences, University Walk, University of Bristol, Bristol BS8 1TD, UK
    Cell Rep 5:1294-301. 2013
    ..Here, we show that posttranslational modification of the active zone protein Rab3-interacting molecule 1α (RIM1α) by the small ubiquitin-like modifier 1 (SUMO-1) functions as a molecular switch to direct these interactions and ..
  11. pmc Rab3 GTPase-activating protein regulates synaptic transmission and plasticity through the inactivation of Rab3
    Ayuko Sakane
    Department of Biochemistry, Institute of Health Biosciences, University of Tokushima Graduate School, 3 18 15 Kuramoto cho, Tokushima 770 8503, Japan
    Proc Natl Acad Sci U S A 103:10029-34. 2006
    ..Thus, Rab3 GAP regulates synaptic transmission and plasticity by limiting the amount of the GTP-bound form of Rab3A...
  12. ncbi Rim, a component of the presynaptic active zone and modulator of exocytosis, binds 14-3-3 through its N terminus
    Lei Sun
    Department of Pharmacology, University of Michigan Medical School, Ann Arbor, Michigan 48109 0632, USA
    J Biol Chem 278:38301-9. 2003
    b>Rim1, a brain-specific Rab3a-binding protein, localizes to the presynaptic cytomatrix and plays an important role in synaptic transmission and synaptic plasticity...
  13. ncbi Solution structure of the RIM1alpha PDZ domain in complex with an ELKS1b C-terminal peptide
    Jun Lu
    Department of Biochemistry, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390, USA
    J Mol Biol 352:455-66. 2005
    ..This groove is formed, in part, by a set of side-chains that is conserved selectively in RIM PDZ domains and that hence determines, at least in part, their unique specificity...
  14. pmc Munc13-1 is required for presynaptic long-term potentiation
    Ying Yang
    Center for Translational Neuroscience, Department of Medicine Neurology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Neurosci 31:12053-7. 2011
    ..Munc13 proteins also interact with RIM1α, an active zone protein required for presynaptic long-term plasticity...
  15. pmc Liprin-α2 promotes the presynaptic recruitment and turnover of RIM1/CASK to facilitate synaptic transmission
    Samantha A Spangler
    Department of Neuroscience, Erasmus Medical Center, 3015GE Rotterdam, Netherlands
    J Cell Biol 201:915-28. 2013
    ..scaffolding proteins but was critical for recruitment of several components of the release machinery, including RIM1 and CASK...
  16. ncbi SAD: a presynaptic kinase associated with synaptic vesicles and the active zone cytomatrix that regulates neurotransmitter release
    Eiji Inoue
    KAN Research Institute, Kyoto 600 8815, Japan
    Neuron 50:261-75. 2006
    ..Furthermore, SAD-B phosphorylates the active zone protein RIM1 but not Munc13-1. These results suggest that mammalian SAD kinase presynaptically regulates neurotransmitter release...
  17. ncbi Binding to Rab3A-interacting molecule RIM regulates the presynaptic recruitment of Munc13-1 and ubMunc13-2
    Yaisa S Andrews-Zwilling
    Department of Molecular Neurobiology, Max Planck Institute of Experimental Medicine, Hermann Rein Strasse 3, D 37075 Gottingen, Germany
    J Biol Chem 281:19720-31. 2006
    ..We conclude that one function of the Munc13/RIM1alpha interaction is the active zone recruitment of Munc13-1 and ubMunc13-2...
  18. pmc Crystal structure of the RIM1alpha C2B domain at 1.7 A resolution
    Rong Guan
    Department of Biochemistry, University of Texas Southwestern Medical Center, 6000 Harry Hines Boulevard, Dallas, Texas 75390, USA
    Biochemistry 46:8988-98. 2007
    ..Our results provide a structural basis to understand the function of RIM C2B domains and suggest that dimerization may be a crucial aspect of RIM function...
  19. pmc A role for the ubiquitin-proteasome system in activity-dependent presynaptic silencing
    Xiaoping Jiang
    Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Neurosci 30:1798-809. 2010
    ..Presynaptic silencing was accompanied by decreases in levels of the priming proteins Munc13-1 and Rim1. Importantly, overexpression of Rim1alpha prevented the induction of persistent presynaptic silencing...
  20. ncbi Adapter protein 14-3-3 is required for a presynaptic form of LTP in the cerebellum
    Fatma Simsek-Duran
    Department of Pathology and Anatomy, Eastern Virginia Medical School, Norfolk, Virginia 23501, USA
    Nat Neurosci 7:1296-8. 2004
    ..Thus, RIM1alpha phosphorylation triggers presynaptic LTP in part through recruitment of 14-3-3 to phospho-Ser413-RIM1alpha...
  21. pmc Physical and functional interaction of the active zone proteins, CAST, RIM1, and Bassoon, in neurotransmitter release
    Etsuko Takao-Rikitsu
    KAN Research Institute, Kyoto Research Park, Shimogyo ku, Kyoto 600 8815, Japan
    J Cell Biol 164:301-11. 2004
    ..novel cytomatrix at the active zone (CAZ)-associated protein, CAST, and found it directly binds another CAZ protein RIM1 and indirectly binds Munc13-1 through RIM1; RIM1 and Munc13-1 directly bind to each other and are implicated in ..
  22. pmc Molecular in situ topology of Aczonin/Piccolo and associated proteins at the mammalian neurotransmitter release site
    Christoph Limbach
    Department of Neuroscience, Uppsala University, S 75124 Uppsala, Sweden
    Proc Natl Acad Sci U S A 108:E392-401. 2011
    ..At both conventional and ribbon synapses, CAST, Munc13, and RIM are segregated from Aczonin, closer to the PM, and Aczonin is positioned such that it may control the access of neurotransmitter vesicles to the fusion site...