Retn

Summary

Gene Symbol: Retn
Description: resistin
Alias: resistin
Species: rat

Top Publications

  1. ncbi Resistin-binding peptide antagonizes role of resistin on white adipose tissue
    Nan Gu
    Department of Pediatrics, Nanjing Maternal and Child Health Hospital of Nanjing Medical University, Nanjing 210029, China
    Acta Pharmacol Sin 28:221-6. 2007
  2. ncbi Mechanical stretch enhances the expression of resistin gene in cultured cardiomyocytes via tumor necrosis factor-alpha
    Bao Wei Wang
    Division of Cardiology, Shin Kong Wu Ho Su Memorial Hospital, Taipei, Taiwan
    Am J Physiol Heart Circ Physiol 293:H2305-12. 2007
  3. ncbi Long-time alcohol intake modifies resistin secretion and expression of resistin gene in adipose tissue
    E Pravdova
    Institute of Experimental Endocrinology, Slovak Academy of Sciences, Vlarska 3, 833 06 Bratislava, Slovakia
    Gen Physiol Biophys 26:221-9. 2007
  4. pmc A paradox: insulin inhibits expression and secretion of resistin which induces insulin resistance
    Feng Liu
    Institute of Pediatrics of Nanjing Maternity and Child Health Hospital of the Nanjing Medical University, Nanjing 210004, Jiangsu Province, China
    World J Gastroenterol 14:95-100. 2008
  5. doi The molecular regulation of resistin expression in cultured vascular smooth muscle cells under hypoxia
    Huei Fong Hung
    Division of Cardiology, Shin Kong Wu Ho Su Memorial Hospital, Taipei, Taiwan
    J Hypertens 26:2349-60. 2008
  6. doi Supraphysiological triiodothyronine doses diminish leptin and adiponectin gene expression, but do not alter resistin expression in calorie restricted obese rats
    R A M Luvizotto
    Department of Clinical Medicine, Botucatu School of Medicine, UNESP University of São Paulo State, Botucatu, Sao Paulo, Brazil
    Horm Metab Res 43:452-7. 2011
  7. ncbi Serum concentrations of leptin, adiponectin and resistin, and their relationship with cardiovascular disease in patients with end-stage renal disease
    Juan J Diez
    Department of Endocrinology, Hospital Ramon y Cajal, Madrid, Spain
    Clin Endocrinol (Oxf) 62:242-9. 2005
  8. ncbi Regulation of resistin by gonadal, thyroid hormone, and nutritional status
    Ruben Nogueiras
    Department of Physiology, Universitario de Santiago, Santiago de Compostela, Spain
    Obes Res 11:408-14. 2003
  9. ncbi The hormone resistin links obesity to diabetes
    C M Steppan
    Department of Medicine, The Penn Diabetes Center, University of Pennsylvania School of Medicine, Philadelphia 19104, USA
    Nature 409:307-12. 2001
  10. pmc Cytokine expression in the visceral adipose tissue after laparoscopic and conventional surgery in a rodent model
    Philipp Lingohr
    Department of General, Visceral, Thoracic and Vascular Surgery, University of Bonn, Sigmund Freud Strasse 25, 53127, Bonn, Germany
    Eur J Med Res 21:4. 2016

Scientific Experts

Detail Information

Publications89

  1. ncbi Resistin-binding peptide antagonizes role of resistin on white adipose tissue
    Nan Gu
    Department of Pediatrics, Nanjing Maternal and Child Health Hospital of Nanjing Medical University, Nanjing 210029, China
    Acta Pharmacol Sin 28:221-6. 2007
    To investigate the direct effects of resistin and resistin-binding peptide (RBP) on lipid metabolism and endocrine function in adipose tissue.
  2. ncbi Mechanical stretch enhances the expression of resistin gene in cultured cardiomyocytes via tumor necrosis factor-alpha
    Bao Wei Wang
    Division of Cardiology, Shin Kong Wu Ho Su Memorial Hospital, Taipei, Taiwan
    Am J Physiol Heart Circ Physiol 293:H2305-12. 2007
    The heart is a resistin target tissue and can function as an autocrine organ...
  3. ncbi Long-time alcohol intake modifies resistin secretion and expression of resistin gene in adipose tissue
    E Pravdova
    Institute of Experimental Endocrinology, Slovak Academy of Sciences, Vlarska 3, 833 06 Bratislava, Slovakia
    Gen Physiol Biophys 26:221-9. 2007
    Elevated serum resistin is implicated in insulin resistance associated with obesity and type 2 diabetes mellitus. Alcohol consumption interferes with the nutritional status, metabolic and hormonal activity of the drinker...
  4. pmc A paradox: insulin inhibits expression and secretion of resistin which induces insulin resistance
    Feng Liu
    Institute of Pediatrics of Nanjing Maternity and Child Health Hospital of the Nanjing Medical University, Nanjing 210004, Jiangsu Province, China
    World J Gastroenterol 14:95-100. 2008
    To confirm whether insulin regulates resistin expression and secretion during differentiation of 3T3-L1 preadipocytes and the relationship of resistin with insulin resistance both in vivo and in vitro.
  5. doi The molecular regulation of resistin expression in cultured vascular smooth muscle cells under hypoxia
    Huei Fong Hung
    Division of Cardiology, Shin Kong Wu Ho Su Memorial Hospital, Taipei, Taiwan
    J Hypertens 26:2349-60. 2008
    b>Resistin has a potential role in atherosclerosis because resistin produces proinflammatory effects in the vascular wall. However, the molecular mechanism of resistin increase in atherosclerosis remains unclear...
  6. doi Supraphysiological triiodothyronine doses diminish leptin and adiponectin gene expression, but do not alter resistin expression in calorie restricted obese rats
    R A M Luvizotto
    Department of Clinical Medicine, Botucatu School of Medicine, UNESP University of São Paulo State, Botucatu, Sao Paulo, Brazil
    Horm Metab Res 43:452-7. 2011
    ..present study determined the effect of T(3) on serum concentrations and gene expression of the adipokines leptin, resistin, and adiponectin in calorie-restricted obese rats...
  7. ncbi Serum concentrations of leptin, adiponectin and resistin, and their relationship with cardiovascular disease in patients with end-stage renal disease
    Juan J Diez
    Department of Endocrinology, Hospital Ramon y Cajal, Madrid, Spain
    Clin Endocrinol (Oxf) 62:242-9. 2005
    ..Our aims were (1) to quantify the serum concentrations of leptin, adiponectin and resistin in uraemic patients on peritoneal dialysis (PD) and haemodialysis (HD), in comparison with patients on ..
  8. ncbi Regulation of resistin by gonadal, thyroid hormone, and nutritional status
    Ruben Nogueiras
    Department of Physiology, Universitario de Santiago, Santiago de Compostela, Spain
    Obes Res 11:408-14. 2003
    b>Resistin was recently identified as a hormone secreted by adipocytes that is under hormonal and nutritional control. This hormone has been suggested to be the link between obesity and type 2 diabetes...
  9. ncbi The hormone resistin links obesity to diabetes
    C M Steppan
    Department of Medicine, The Penn Diabetes Center, University of Pennsylvania School of Medicine, Philadelphia 19104, USA
    Nature 409:307-12. 2001
    ..Here we show that adipocytes secrete a unique signalling molecule, which we have named resistin (for resistance to insulin)...
  10. pmc Cytokine expression in the visceral adipose tissue after laparoscopic and conventional surgery in a rodent model
    Philipp Lingohr
    Department of General, Visceral, Thoracic and Vascular Surgery, University of Bonn, Sigmund Freud Strasse 25, 53127, Bonn, Germany
    Eur J Med Res 21:4. 2016
    ..However, an in vivo experimental evidence is lacking and is the issue of our present study...
  11. doi Vitamin D deficiency in obese rats exacerbates nonalcoholic fatty liver disease and increases hepatic resistin and Toll-like receptor activation
    Christian L Roth
    Division of Endocrinology, Seattle Children s Hospital Research Institute, 1900 Ninth Avenue, Seattle, WA 98101, USA
    Hepatology 55:1103-11. 2012
    ..48, P < 0.05). Hepatic messenger RNA (mRNA) levels of Toll-like receptors (TLR)2, TLR4, and TLR9, as well as resistin, interleukins (IL)-1β, IL-4, and IL-6 and oxidative stress marker heme oxygenase (HO)-1, were higher in WD+VDD ..
  12. ncbi [The relationship between resistin and the peripheral neuropathy in type 2 diabetes]
    Xiao Hong Wang
    Deptment of Rehabilitation, Second Hospital of Shandong University, Jinan 250033, China
    Zhonghua Yi Xue Za Zhi 87:1755-7. 2007
    To investigate the relationship between the serum resistin concentration and type 2 DM with peripheral neuropathy.
  13. doi Resistin gene promoter region polymorphism and the risk of hypertrophic cardiomyopathy in patients
    Sabir Hussain
    Department of Biochemistry, Quaid i Azam University, Islamabad 45320, Pakistan
    Transl Res 155:142-7. 2010
    b>Resistin, a novel cytokine, is associated with an inflammatory process and is suggested to induce hypertrophy in rat cardiomyocytes. Resistin gene expression has not been investigated in patients with hypertrophic cardiomyopathy (HCM)...
  14. pmc Experimental hyperthyroidism decreases gene expression and serum levels of adipokines in obesity
    Renata de Azevedo Melo Luvizotto
    Department of Internal Medicine, Botucatu School of Medicine, University of Sao Paulo State, 18618 000 Botucatu, SP, Brazil
    ScientificWorldJournal 2012:780890. 2012
    To analyze the influence of hyperthyroidism on the gene expression and serum concentration of leptin, resistin, and adiponectin in obese animals.
  15. pmc Over expression of resistin in adipose tissue of the obese induces insulin resistance
    - Sadashiv
    Sadashiv, Sunita Tiwari, S Dhananjai, Department of Physiology, CSM Medical University, Lucknow 226003, India
    World J Diabetes 3:135-41. 2012
    To compare resistin mRNA expression in subcutaneous adipose tissue (SAT) and its correlation with insulin resistance (IR) in postmenopausal obese women.
  16. doi Adiponectin and resistin protect steatotic livers undergoing transplantation
    Monica B Jimenez-Castro
    Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, Barcelona, Spain
    J Hepatol 59:1208-14. 2013
    ..Controversial roles for adiponectin and related adipocytokines visfatin and resistin have been described in different liver pathologies, nevertheless it is unknown their possible implication in ..
  17. pmc Resistin mediates the hepatic stellate cell phenotype
    Zhi Xia Dong
    Department of Infectious Disease, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200240, China
    World J Gastroenterol 19:4475-85. 2013
    To describe the role of resistin in liver fibrosis.
  18. ncbi The effect of L-arginine supplementation on serum resistin concentration in insulin resistance in animal models
    M Szulińska
    Department of Internal Medicine, Metabolic Disorders and Hypertension, Poznan University of Medical Sciences, Poznan, Poland
    Eur Rev Med Pharmacol Sci 18:575-80. 2014
    ..Understanding the mechanism of development of the insulin resistance associated with obesity is crucial in identifying new therapeutic options for obese patients...
  19. doi Regulation of adipokines by polyunsaturated fatty acids in a rat model of non-alcoholic steatohepatitis
    Wen Jin Ding
    Department of Gastroenterology, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200092
    Arch Iran Med 17:563-8. 2014
    ..Thus, the aim of our study was to investigate the effects of PUFAs on adipokines, as well as lipid and glycometabolism, in a rat model of non-alcoholic steatohepatitis (NASH)...
  20. pmc (13)C metabolic flux analysis shows that resistin impairs the metabolic response to insulin in L6E9 myotubes
    Shirley Guzmán
    Department of Biochemistry and Molecular Biology, Faculty of Biology, Universitat de Barcelona, Av Diagonal 643, 08028, Barcelona, Spain
    BMC Syst Biol 8:109. 2014
    It has been suggested that the adipokine resistin links obesity and insulin resistance, although how resistin acts on muscle metabolism is controversial...
  21. doi The adipocytokine resistin stimulates the production of proinflammatory cytokines TNF-α and IL-6 in pancreatic acinar cells via NF-κB activation
    C Y Jiang
    Department of General Surgery, Huadong Hospital affiliated to Fudan University, Shanghai 200040, China
    J Endocrinol Invest 36:986-92. 2013
    b>Resistin, an adipocytokine secreted by fat tissues, has been associated with the inflammatory response, though its role in inflammation during acute pancreatitis (AP) remains unclear.
  22. pmc Diet-induced variability of the resistin gene (Retn) transcript level and methylation profile in rats
    Joanna Nowacka-Woszuk
    Department of Genetics and Animal Breeding, Poznan University of Life Sciences, Wolynska 33, 60 637, Poznan, Poland
    BMC Genet 16:113. 2015
    ..One of the important factors produced in fat tissue is resistin (Retn). It has been postulated that this hormone is involved in glucose homeostasis and insulin resistance...
  23. pmc Sitagliptin decreases ventricular arrhythmias by attenuated glucose-dependent insulinotropic polypeptide (GIP)-dependent resistin signalling in infarcted rats
    Tsung Ming Lee
    Department of Medicine, Cardiology Section, China Medical University An Nan Hospital, Tainan 70911, Taiwan Department of Medicine, China Medical University, Taichung 40447, Taiwan Cardiovascular Research Laboratory, China Medical University Hospital, Taichung 40447, Taiwan Division of Cardiology, Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei 11031, Taiwan
    Biosci Rep 36:. 2016
    Myocardial infarction (MI) was associated with insulin resistance, in which resistin acts as a critical mediator...
  24. pmc Hyperresistinemia - a novel feature in systemic infection during human pregnancy
    Shali Mazaki-Tovi
    Perinatology Research Branch, Intramural Division, NICHD NIH DHHS, Hutzel Women s Hospital, Bethesda, MD, USA
    Am J Reprod Immunol 63:358-69. 2010
    b>Resistin, originally described as an adipokine, has emerged as a potent pro-inflammatory protein associated with both acute and chronic inflammation...
  25. ncbi Serum resistin is associated with the severity of microangiopathies in type 2 diabetes
    Haruhiko Osawa
    Department of Molecular and Genetic Medicine, Ehime, University Graduate School of Medicine, Toon, Ehime 791 0295, Japan
    Biochem Biophys Res Commun 355:342-6. 2007
    b>Resistin, secreted from adipocytes, causes insulin resistance and diabetes in rodents. To determine the relation between serum resistin and diabetic microangiopathies in humans, we analyzed 238 Japanese T2DM subjects...
  26. ncbi [The significance of resistin concentration in metabolical diseases]
    Dragisa Rasić
    Medicinski fakultet Univerziteta Pristina Kosovska Mitrovica, Interna klinika, Pristina Kosovska Mitrovica, Srbija
    Vojnosanit Pregl 67:965-8. 2010
    ..The aim of this study was to determine the resistin significance in patients with various forms of metabolic diseases.
  27. pmc Serum resistin levels in critically ill patients are associated with inflammation, organ dysfunction and metabolism and may predict survival of non-septic patients
    Alexander Koch
    Department of Medicine III, RWTH University Hospital Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany
    Crit Care 13:R95. 2009
    ..The pathogenesis of insulin resistance (IR) in critically ill patients is complex and not fully understood. Resistin is a hormone mainly derived from macrophages in humans and from adipose tissue in rodents, which regulates ..
  28. doi Expression and effect of resistin on bovine and rat granulosa cell steroidogenesis and proliferation
    Virginie Maillard
    Unite de Physiologie de la Reproduction et des Comportements, UMR85, Equipe Métabolisme et Reproduction, Institut National de la Recherche Agronomique, F 37 380 Nouzilly, France
    Reproduction 141:467-79. 2011
    b>Resistin, initially identified in adipose tissue and macrophages, was implicated in insulin resistance...
  29. doi Resistin contributes to neointimal formation via oxidative stress after vascular injury
    Kou Gi Shyu
    Department of Neurology, Shin Kong Wu Ho Su Memorial Hospital, Taipei, Taiwan
    Clin Sci (Lond) 120:121-9. 2011
    b>Resistin may play a major potential role in vascular remodelling and may contribute to atherogenesis. However, the role of VSMC (vascular smooth muscle cell)-derived resistin in neointimal formation is not well understood...
  30. doi Association of resistin with urinary albumin excretion in nondiabetic patients with essential hypertension
    Costas Tsioufis
    First Cardiology Clinic, Hippokration Hospital, University of Athens, Athens, Greece
    Am J Hypertens 23:681-6. 2010
    Evidence suggests that resistin, a recently described protein, is associated with subclinical atherosclerosis in different clinical settings...
  31. doi Plasma adiponectin and resistin levels as predictors of mortality in patients with acute myocardial infarction: data from infarction prognosis study registry
    Sang Hak Lee
    Cardiology Division, Yonsei University College of Medicine, Seoul, Korea
    Coron Artery Dis 20:33-9. 2009
    Adiponectin and resistin, which have counteracting effects, are suggested to be associated with inflammation and atherosclerosis. The relationship between their levels and prognosis in high risk patients is, however, still unclear...
  32. doi High resistin and interleukin-6 levels are associated with gestational diabetes mellitus
    Mariusz Kuzmicki
    Department of Pathophysiology of Pregnancy, Medical University of Bialystok, Bialystok, Poland
    Gynecol Endocrinol 25:258-63. 2009
    b>Resistin is a cysteine-rich adipokine originally described as a molecular link between obesity and insulin resistance in rodents...
  33. doi Isolation and identification of potential urinary microparticle biomarkers of bladder cancer
    David M Smalley
    Mellon Medical Biomarker Discovery Laboratory, W M Keck Laboratory for Mass Spectrometry, Department of Urology, University of Virginia, Charlottesville, Virginia 22908, USA
    J Proteome Res 7:2088-96. 2008
    ..five proteins associated with the epidermal growth factor receptor pathway, the alpha subunit of GsGTP binding protein, resistin, and retinoic acid-induced protein 3. Further studies will be needed to validate these potential biomarkers.
  34. pmc Resistin promotes cardiac hypertrophy via the AMP-activated protein kinase/mammalian target of rapamycin (AMPK/mTOR) and c-Jun N-terminal kinase/insulin receptor substrate 1 (JNK/IRS1) pathways
    Soojeong Kang
    Cardiovascular Research Institute, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Biol Chem 286:18465-73. 2011
    b>Resistin has been suggested to be involved in the development of diabetes and insulin resistance...
  35. ncbi Resistin, a new adipokine, is related to inflammation and renal function in kidney allograft recipients
    J Malyszko
    Department of Nephrology and Transplantology
    Transplant Proc 38:3434-6. 2006
    Among patients without chronic kidney disease, resistin, an adipocytokine, has been related to inflammatory markers, coronary artery disease, and cardiovascular disease in the metabolic syndrome...
  36. doi Resistin level in coronary artery disease and heart failure: the central role of kidney function
    Samuele Baldasseroni
    Department of Critical Care Medicine and Surgery, University of Florence and Azienda Ospedaliero Universitaria Careggi, Viale Morgagni 85, Florence, Italy
    J Cardiovasc Med (Hagerstown) 14:150-7. 2013
    The aim of this study was to evaluate resistin levels in patients with coronary artery disease (CAD) with or without chronic heart failure, in order to define its independent predictor.
  37. ncbi Improvement of lipid profile and reduction of body weight by shan he jian fei granules in high fat diet-induced obese rats
    Sheng Yun Sun
    Institute of Qi and Blood of Integrative Medicine, Jinan University, Guangzhou 510630, China
    Clin Lab 58:81-7. 2012
    The goal was to study lipid profiles (TG, TC, LDL, HDL), effects on serum leptin, and fat tissue adiponectin, and resistin as well as body weight effects of Shan He Jian Fei Granules (SHJFG) in rats on a high fat diet.
  38. pmc Correlates of resistin in children with chronic kidney disease: the chronic kidney disease in children cohort
    Edward Nehus
    Division of Nephrology and Hypertension, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    J Pediatr 161:276-80. 2012
    To test the hypothesis that resistin is associated with insulin resistance and inflammation in pediatric patients with chronic kidney disease (CKD).
  39. pmc Low resistin level is associated with poor hospitalization-free survival in hemodialysis patients
    Wookyung Chung
    Department of Internal Medicine, Gachon University of Medicine and Science, Incheon, Korea
    J Korean Med Sci 27:377-81. 2012
    Malnutrition and inflammation are related to high rates of morbidity and mortality in hemodialysis patients. Resistin is associated with nutrition and inflammation...
  40. doi Infliximab modifies mesenteric adipose tissue alterations and intestinal inflammation in rats with TNBS-induced colitis
    Thayane Rodrigues Leite Clemente
    Clinical Pharmacology and Gastroenterology Unit, Sao Francisco University Medical School, Braganca Paulista, SP, Brazil
    Scand J Gastroenterol 47:943-50. 2012
    ....
  41. ncbi Identification of variables influencing resistin serum levels in patients with type 1 and type 2 diabetes mellitus
    A Schaffler
    Department of Internal Medicine I, University of Regensburg, D 93042 Regensburg, Germany
    Horm Metab Res 36:702-7. 2004
    b>Resistin, a peptide hormone, has been discussed controversially as a missing link between obesity and insulin resistance...
  42. doi Central resistin enhances renal sympathetic nerve activity via phosphatidylinositol 3-kinase but reduces the activity to brown adipose tissue via extracellular signal-regulated kinase 1/2
    S Kosari
    School of Medical Sciences and Health Innovations Research Institute, RMIT University, Melbourne, Victoria, Australia
    J Neuroendocrinol 24:1432-9. 2012
    b>Resistin is an adipokine, originally identified in adipose tissue, and its plasma levels are elevated in obesity...
  43. ncbi [Effects of resistin on hepatic fibrosis: possible mechanisms in non-alcoholic fatty liver disease in in vitro and in vivo]
    Yun Peng Yang
    Department of Pathology, Chongqing Medical University, Chongqing, China
    Dongwuxue Yanjiu 33:367-72. 2012
    To investigate the effects and possible mechanisms of resistin on hepatic fibrosis in non-alcoholic fatty liver disease, this review used an in vivo model utilizing Wistar rats with a high fat diet...
  44. pmc Impact of uremia on human adipose tissue phenotype
    Karen J Ho
    Department of Surgery, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Surg Res 179:175-82. 2013
    ..We hypothesized that adipose from uremic patients holds a relatively higher adipose-derived hormone and proinflammatory adipokine signature; we simultaneously evaluated the impact of clinical parameters on adipose phenotype...
  45. doi Inverse association between serum resistin and insulin resistance in humans
    S Dominguez Coello
    Research Unit, La Candelaria Universitary Hospital and Primary Health Care, Canary Health Service, Santa Cruz de Tenerife, Canary Islands, Spain
    Diabetes Res Clin Pract 82:256-61. 2008
    To determine how serum concentrations of resistin are distributed in humans in relation to insulin resistance, type 2 diabetes, and obesity.
  46. doi Polymorphism in resistin promoter region at -420 determines the serum resistin levels and may be a risk marker of stroke in Japanese type 2 diabetic patients
    Takayoshi Tsukahara
    Department of Endocrinology and Diabetes, Nagoya University Graduate School of Medicine, 65 Tsuruma cho, Showa Ku, Nagoya 466 8550, Japan
    Diabetes Res Clin Pract 84:179-86. 2009
    b>Resistin, which appears to be related to insulin resistance, is secreted mainly from macrophages in human and some of its polymorphisms have been reported...
  47. doi Association of -394C>G and -420C>G polymorphisms in the RETN gene with T2DM and CHD and a new potential SNP might be exist in exon 3 of RETN gene in Chinese
    Shuguang Chi
    Department of Cell Biology and Genetics, and Center of Neuroscience, Fujian Medical University, 88 Jiaotong Road, Fuzhou, 350004, China
    Mol Cell Biochem 330:31-8. 2009
    Genetic variations of the human RETN gene are associated with metabolic phenotypes, including obesity, insulin sensitivity, diabetes, and coronary heart disease (CHD)...
  48. doi Possible common central pathway for resistin and insulin in regulating food intake
    C Cifani
    Department of Experimental Medicine and Public Health, University of Camerino, 62032 Camerino, Italy
    Acta Physiol (Oxf) 196:395-400. 2009
    ..Examination of adipocyte-secreted peptides led to the identification of a unique polypeptide, resistin (RSTN), which has been suggested as a link between obesity and diabetes...
  49. doi Resistin regulates pituitary somatotrope cell function through the activation of multiple signaling pathways
    Francisca Rodriguez-Pacheco
    Department of Cell Biology, Edificio Severo Ochoa, University of Cordoba, E 14014 Cordoba, Spain
    Endocrinology 150:4643-52. 2009
    The adipokine resistin is an insulin-antagonizing factor that also plays a regulatory role in inflammation, immunity, food intake, and gonadal function...
  50. ncbi A pilot study suggests that the G/G genotype of resistin single nucleotide polymorphism at -420 may be an independent predictor of a reduction in fasting plasma glucose and insulin resistance by pioglitazone in type 2 diabetes
    Hideichi Makino
    Institute of Diabetes Research Center, Takanoko Hospital, Ehime, Japan
    Endocr J 56:1049-58. 2009
    The aim of this study was to determine the relation between the G/G genotype of a resistin gene promoter single nucleotide polymorphism (SNP) at -420 (rs1862513) and glycemic control by pioglitazone in type 2 diabetes...
  51. ncbi [Role of resistin in inflammation of hepatocytes in nonalcoholic steatohepatitis]
    Cai Yan Zhao
    Department of Infectious Disease, Third Affiliated Hospital, Hebei Medical University, Shijiazhuang 050051, China
    Zhonghua Gan Zang Bing Za Zhi 17:683-7. 2009
    To investigate the role and molecular mechanism of resistin in inflammation of hepatocytes in nonalcoholic steatohepatitis.
  52. ncbi Regulation of resistin by cyclic mechanical stretch in cultured rat vascular smooth muscle cells
    Bao Wei Wang
    School of Medicine, Fu Jen Catholic University, Taipei County, Taiwan
    Clin Sci (Lond) 118:221-30. 2009
    b>Resistin has a potential role in atherosclerosis; however, the molecular mechanism underlying the increase in resistin expression in atherosclerosis remains unclear...
  53. doi S-resistin inhibits adipocyte differentiation and increases TNFalpha expression and secretion in 3T3-L1 cells
    Carmen M Fernández
    Centro Regional de Investigaciones Biomédicas, Universidad de Castilla La Mancha, Toledo, Spain
    Biochim Biophys Acta 1803:1131-41. 2010
    S-resistin is a non-secretable resistin spliced variant described in white adipose tissue from Wistar rats...
  54. doi Centrally administered resistin enhances sympathetic nerve activity to the hindlimb but attenuates the activity to brown adipose tissue
    S Kosari
    School of Medical Sciences, Royal Melbourne Institute of Technology University, P O Box 71, Bundoora 3083, Melbourne, Victoria, Australia
    Endocrinology 152:2626-33. 2011
    b>Resistin, an adipokine, is believed to act in the brain to influence energy homeostasis. Plasma resistin levels are elevated in obesity and are associated with metabolic and cardiovascular disease...
  55. ncbi CNS melanocortin and leptin effects on stearoyl-CoA desaturase-1 and resistin expression
    Ji Lin
    Department of Animal and Dairy Science, University of Georgia, Athens, GA 30602, USA
    Biochem Biophys Res Commun 311:324-8. 2003
    ..was to determine whether centrally administered leptin decreased liver and adipose SCD1 expression or adipose resistin expression, and whether these effects were mediated by central melanocortin receptors...
  56. ncbi Short-term pioglitazone treatment prevents free fatty acid-induced hepatic insulin resistance in normal rats: possible role of the resistin and adiponectin
    Gangyi Yang
    Department of Endocrinology, The Second Affiliated Hospital, Chongqing University of Medical Sciences, Chongqing 400010, China
    Biochem Biophys Res Commun 339:1190-6. 2006
    ..with pioglitazone (Pio, 4mg/kg x d) on hepatic and peripheral insulin sensitivity, plasma adiponectin, and resistin concentrations in lipid-infused rats...
  57. ncbi Association of resistin with visceral fat and muscle insulin resistance
    Stephen E Borst
    Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL 32611 8206, USA
    Cytokine 32:39-44. 2005
    ..058). Glucose tolerance was not significantly affected by surgical fat removal. In VF- animals, serum resistin was reduced 26% (p<0.05) and serum adiponectin was reduced 30% (p<0...
  58. ncbi Effects of free fatty acids on plasma resistin and insulin resistance in awake rats
    Gangyi Yang
    Department of Endocrinology, The Second Affiliated Hospital, Chongqing Medical University, Chongqing 400010, China
    Metabolism 54:1142-6. 2005
    b>Resistin has been postulated to play a role in obesity-related insulin resistance. To explore this possibility, we have investigated effects of acute euglycemic (5.2+/-0...
  59. ncbi Stimulated resistin expression in white adipose of rats with bile duct ligation-induced liver cirrhosis: relationship to cirrhotic hyperinsulinemia and increased tumor necrosis factor-alpha
    Shih Yi Lin
    Division of Endocrinology and Metabolism, Department of Medicine, Taichung Veterans General Hospital, Taichung, Taiwan
    Mol Cell Endocrinol 232:1-8. 2005
    b>Resistin, an adipose-derived polypeptide hormone, is proposed as a candidate of insulin resistance, although its roles in inhibiting adipogenesis and in inflammation have also been suggested...
  60. ncbi Resistin mRNA levels are downregulated by estrogen in vivo and in vitro
    Seng Wong Huang
    School of Medicine, National Yang Ming University, Taipei, Taiwan
    FEBS Lett 579:449-54. 2005
    b>Resistin, a hormone secreted by adipocytes, is suggested to be an important link between obesity and diabetes...
  61. ncbi An update on the biology and physiology of resistin
    E Adeghate
    Department of Anatomy, Faculty of Medicine and Health Sciences, United Arab Emirates University, P O Box 17666, Al Ain, United Arab Emirates
    Cell Mol Life Sci 61:2485-96. 2004
    b>Resistin is a newly discovered adipocyte hormone. It is related to resistin-like molecules alpha, beta and gamma in structure and function...
  62. ncbi Novel expression of resistin in rat testis: functional role and regulation by nutritional status and hormonal factors
    Ruben Nogueiras
    Department of Physiology, University of Santiago de Compostela, C San Francisco s n, 15705, Spain
    J Cell Sci 117:3247-57. 2004
    b>Resistin, a recently cloned adipose-secreted factor, is primarily involved in the modulation of insulin sensitivity and adipocyte differentiation...
  63. ncbi Resistin promotes 3T3-L1 preadipocyte differentiation
    Haixia Gong
    Department of Pediatrics, The Second Affiliated Hospital of Nanjing Medical University, 121 Jiangjiayuan Road, Nanjing, 210011, People s Republic of China
    Eur J Endocrinol 150:885-92. 2004
    To investigate the relationship between resistin (a potential link between obesity and type 2 diabetes) and preadipocyte differentiation.
  64. ncbi Alternative splicing generates a novel non-secretable resistin isoform in Wistar rats
    A Del Arco
    Area de Bioquímica, Centro Regional de Investigaciones Biomédicas CRIB, Facultad de Ciencias del Medio Ambiente, Universidad de Castilla La Mancha, Av De Carlos III s n, 45071, Toledo, Spain
    FEBS Lett 555:243-9. 2003
    b>Resistin is a secreted adipose tissue hormone that belongs to the resistin-like molecule family...
  65. ncbi Resistin as a putative modulator of insulin action in the daily feeding/fasting rhythm
    P Oliver
    Laboratory of Molecular Biology, Nutrition and Biotechnology, Department of Fundamental Biology and Health Sciences, University of the Balearic Islands, Cra Valldemossa Km 7 5, 07122, Palma de Mallorca, Spain
    Pflugers Arch 452:260-7. 2006
    b>Resistin and adiponectin are adipokines with postulated opposite functions. Resistin has been related with insulin resistance in obesity, while adiponectin could be associated to higher insulin sensitivity...
  66. ncbi Resistin expression in different adipose tissue depots during rat development
    Paula Oliver
    Laboratori de Biologia Molecular, Nutrició i Biotecnologia, Departament de Biologia Fonamental i Ciencies de la Salut, Universitat de les Illes Balears, Palma de Mallorca, Spain
    Mol Cell Biochem 252:397-400. 2003
    b>Resistin is a hormonal factor synthesised by adipocytes that was first thought to be related with the resistance to insulin in obesity, but whose function is not yet completely established...
  67. ncbi Transgenic and recombinant resistin impair skeletal muscle glucose metabolism in the spontaneously hypertensive rat
    Michal Pravenec
    Institute of Physiology, Czech Academy of Sciences and The Center for Integrated Genomics, Prague 14220, Czech Republic
    J Biol Chem 278:45209-15. 2003
    Increased serum levels of resistin, a molecule secreted by fat cells, have been proposed as a possible mechanistic link between obesity and insulin resistance...
  68. ncbi Resistin is expressed in different rat tissues and is regulated in a tissue- and gender-specific manner
    Ruben Nogueiras
    Department of Physiology, University of Santiago de Compostela, School of Medicine, 15705, Santiago de Compostela, Spain
    FEBS Lett 548:21-7. 2003
    b>Resistin is a polypeptide hormone first reported from human and rodent adipocytes. In order to better define the potential biological role of resistin we undertook a detailed analysis of its expression in different rat tissues...
  69. ncbi Effect of acute cold exposure on the expression of the adiponectin, resistin and leptin genes in rat white and brown adipose tissues
    M Puerta
    Department of Animal Biology II Physiology, Faculty of Biological Sciences, Complutense University, Madrid, Spain
    Horm Metab Res 34:629-34. 2002
    Leptin, adiponectin, and resistin are key hormones produced by adipose tissue...
  70. ncbi Association of resistin gene 3'-untranslated region +62G-->A polymorphism with type 2 diabetes and hypertension in a Chinese population
    Mian Shin Tan
    Department of Biology, Kaohsiung Medical University, Pingtung 90000, Taiwan
    J Clin Endocrinol Metab 88:1258-63. 2003
    b>Resistin, a recently discovered polypeptide, antagonizes insulin action and may play a part in the pathogenesis of insulin resistance. This study investigates whether resistin gene polymorphism can be associated with type 2 diabetes...
  71. ncbi Resistin and adiponectin expression in visceral fat of obese rats: effect of weight loss
    Gabriella Milan
    Endocrine Metabolic Laboratory, Internal Medicine, Department of Medical and Surgical Sciences, University of Padova, 35128 Padova, Italy
    Obes Res 10:1095-103. 2002
    ..have been implicated in the development of type 2 diabetes, among them, the recently discovered adiponectin and resistin proteins...
  72. pmc Selective parasympathetic innervation of subcutaneous and intra-abdominal fat--functional implications
    Felix Kreier
    Netherlands Institute for Brain Research, Amsterdam, The Netherlands
    J Clin Invest 110:1243-50. 2002
    ..Moreover, expression of resistin and leptin mRNA decreased, whereas adiponectin mRNA did not change...
  73. ncbi Lipopolysaccharide increases resistin gene expression in vivo and in vitro
    Shao Chun Lu
    Department of Biochemistry and Molecular Biology, College of Medicine, National Taiwan University, No 1, Sec 1, Jen Ai Road, Taipei 100, Taiwan
    FEBS Lett 530:158-62. 2002
    Although resistin has been thought to be an important link between obesity and diabetes, recent results do not support this hypothesis...
  74. ncbi Growth hormone rapidly induces resistin gene expression in white adipose tissue of spontaneous dwarf (SDR) rats
    Patric J D Delhanty
    Kolling Institute of Medical Research, Royal North Shore Hospital, University of Sydney, St Leonards, NSW, Australia
    Endocrinology 143:2445-8. 2002
    ..A possible mediator of these effects is the recently identified white adipose tissue (WAT)-derived factor resistin that has been shown to impair glucose tolerance and inhibit adipocyte differentiation...
  75. ncbi Long-term effects of central leptin and resistin on body weight, insulin resistance, and beta-cell function and mass by the modulation of hypothalamic leptin and insulin signaling
    Sunmin Park
    Department of Food and Nutrition, Hoseo University, Asan Si, Chungnam Do, Korea
    Endocrinology 149:445-54. 2008
    To determine the long-term effect of central leptin and resistin on energy homeostasis, peripheral insulin resistance, and beta-cell function and mass, intracerebroventricular (ICV) infusion of leptin (3 ng/h), resistin (80 ng/h), leptin ..
  76. doi The expression of rat resistin isoforms is differentially regulated in visceral adipose tissues: effects of aging and food restriction
    Carmen M Fernández
    Area de Bioquímica, Centro Regional de Investigaciones Biomédicas CRIB, Facultad de Ciencias del Medio Ambiente, Universidad de Castilla La Mancha, Av Carlos III s n 45071 Toledo, Spain
    Metabolism 58:204-11. 2009
    Two variants of the adipose hormone resistin are generated by alternative splicing in Wistar rats...
  77. doi Resistin increases lipid accumulation by affecting class A scavenger receptor, CD36 and ATP-binding cassette transporter-A1 in macrophages
    Tzong Shyuan Lee
    Institute of Physiology, School of Medicine, National Yang Ming University, Taiwan
    Life Sci 84:97-104. 2009
    b>Resistin promotes macrophage-foam cell formation, but the mechanisms are unclear...
  78. pmc Role of resistin in cardiac contractility and hypertrophy
    Maengjo Kim
    Cardiovascular Research Center, Mount Sinai School of Medicine, USA
    J Mol Cell Cardiol 45:270-80. 2008
    ..Recently, a novel paradigm for the role of the adipocytokine resistin in diabetes has emerged. Resistin has been proposed to be a link between obesity, insulin resistance and diabetes...
  79. doi Central resistin regulates hypothalamic and peripheral lipid metabolism in a nutritional-dependent fashion
    Maria J Vazquez
    Department of Physiology, School of Medicine, University of Santiago de Compostela, Santiago de Compostela, Spain
    Endocrinology 149:4534-43. 2008
    Evidence suggests that the adipocyte-derived hormone resistin (RSTN) directly regulates both feeding and peripheral metabolism through, so far, undefined hypothalamic-mediated mechanisms...
  80. doi Adiponectin and resistin response in the onset of obesity in male and female rats
    Joan Ribot
    Laboratory of Molecular Biology, Nutrition and Biotechnology, University of the Balearic Islands, Palma de Mallorca, Spain
    Obesity (Silver Spring) 16:723-30. 2008
    Studying the sex-dependent response of adiponectin and resistin adipose tissue expression and circulating levels in the onset of dietary obesity.
  81. pmc Traumatic brain injury induces adipokine gene expression in rat brain
    Russell Brown
    Department of Physiology and Biophysics, Dalhousie University, Halifax, Nova Scotia, Canada
    Neurosci Lett 432:73-8. 2008
    ..Adipokine genes such as leptin (ob), resistin (rstn) and fasting-induced adipose factor (fiaf) are implicated in energy metabolism and body weight control and ..
  82. pmc The +299(G>A) resistin gene polymorphism and susceptibility to type 2 diabetes in Thais
    Kanjana Suriyaprom
    Department of Medical Technology, Faculty of Medical Technology, Rangsit University, Paholyothin Road, Pathumthani 12000, Thailand
    J Clin Biochem Nutr 44:104-10. 2009
    The prevalence of type 2 diabetes has been increased in Thais. Resistin is an adipokine that involve in glucose homeostasis and is a candidate gene for type 2 diabetes...
  83. ncbi Effect of resistin on vascular endothelium secretion dysfunction in rats
    Yan Li
    Department of Pediatrics, Shandong Provincial Hospital, Shandong University, Jinan, People s Republic of China
    Endothelium 14:207-14. 2007
    b>Resistin, a novel adipokine, was recently suggested to be involved in the development of endothelial dysfunction. However, the mechanisms of how resistin works are still unknown...
  84. ncbi Resistin is a key mediator of glucose-dependent insulinotropic polypeptide (GIP) stimulation of lipoprotein lipase (LPL) activity in adipocytes
    Su Jin Kim
    Department of Cellular and Physiological Sciences and the Diabetes Research Group, Life Sciences Institute, University of British Columbia, Vancouver, British Columbia, Canada
    J Biol Chem 282:34139-47. 2007
    ..of an intermediary molecule, and the current studies focused on the possible contribution of the adipokine resistin. In differentiated 3T3-L1 adipocytes, GIP, in the presence of insulin, increased resistin secretion through a ..
  85. ncbi Control by reproduction-related hormones of resistin expression and plasma concentration
    S Caja
    Department of Animal Physiology II, Faculty of Biological Sciences, Complutense University, Madrid, Spain
    Horm Metab Res 39:501-6. 2007
    Although not simultaneously, resistin expression in white adipose tissue (WAT) and resistin plasma concentration have been shown to increase in pregnant rats...
  86. ncbi [Overexpression of resistin affect 3T3-L1 adipocyte lipid metabolism]
    Nan Gu
    Department of Pediatrics, Nanjing Maternal and Child Health Hospital, Nanjing, Jiangsu, 210004 PR China
    Zhonghua Yi Xue Yi Chuan Xue Za Zhi 24:251-5. 2007
    To investigate the effect of resistin overexpression on 3T3-L1 adipocyte lipid and glucose metabolism.
  87. ncbi Effect of PPAR-delta agonist on the expression of visfatin, adiponectin, and resistin in rat adipose tissue and 3T3-L1 adipocytes
    K C Choi
    Division of Endocrinology and Metabolism, Department of Internal Medicine, Korea University College of Medicine, Guro Gu, Seoul 152 050, Republic of Korea
    Biochem Biophys Res Commun 357:62-7. 2007
    ..We examined the expression of visfatin, adiponectin, and resistin mRNA in visceral adipose tissue of Wistar rats fed a high-fat diet and 3T3-L1 adipocytes treated with PPAR-delta ..
  88. ncbi Insulin sensitivity and resistin expression in nitric oxide-deficient rats
    C C Juan
    Department of Physiology, School of Medicine, National Yang Ming University, Taipei, Taiwan
    Diabetologia 49:3017-26. 2006
    The aim of this study was to investigate changes in insulin sensitivity and expression of the gene encoding resistin (Retn) in adipocytes from long-term nitric oxide (NO)-deficient rats.
  89. ncbi Resistin worsens cardiac ischaemia-reperfusion injury
    Sarah E Rothwell
    Christchurch Cardioendocrine Research Group, Department of Medicine, Christchurch School of Medicine and Health Sciences, University of Otago, Christchurch, New Zealand
    Biochem Biophys Res Commun 349:400-7. 2006
    We provide the first report of direct effects of resistin upon haemodynamic and neurohumoral parameters in isolated perfused rat heart preparations...