Reg3a

Summary

Gene Symbol: Reg3a
Description: regenerating islet-derived 3 alpha
Alias: Pap2, PapII, regenerating islet-derived protein 3-alpha, REG 3, REG-3-alpha, islet of Langerhans regenerating protein 3, lithostathine 3, pancreatitis-associated protein 2, reg III-alpha, regIII, regenerating islet-derived protein III-alpha
Species: rat

Top Publications

  1. pmc Small-interference RNA gene knockdown of pancreatitis-associated proteins in rat acute pancreatitis
    Yin Yao Lin
    SUNY Downstate Medical Center, Brooklyn, NY 11203, USA
    Pancreas 36:402-10. 2008
  2. ncbi Pancreatitis-associated protein 2 modulates inflammatory responses in macrophages
    Domenico Viterbo
    Department of Surgery, Downstate Medical Center, State University of New York, Brooklyn, NY 11203, USA
    J Immunol 181:1948-58. 2008
  3. ncbi Mutational characterization of pancreatitis-associated protein 2 domains involved in mediating cytokine secretion in macrophages and the NF-kappaB pathway
    Domenico Viterbo
    Department of Surgery, Downstate Medical Center, State University of New York, Brooklyn, NY 11203, USA
    J Immunol 181:1959-68. 2008
  4. pmc Administration of anti-Reg I and anti-PAPII antibodies worsens pancreatitis
    Domenico Viterbo
    Department of Surgery, SUNY Downstate Medical Center, Brooklyn, NY, USA
    JOP 10:15-23. 2009
  5. pmc Microarray analysis of rat pancreas reveals altered expression of Alox15 and regenerating islet-derived genes in response to iron deficiency and overload
    Richard Coffey
    Food Science and Human Nutrition Department, University of Florida, Gainesville, Florida, United States of America
    PLoS ONE 9:e86019. 2014
  6. doi Islet neogenesis-associated protein (INGAP)-positive cell mass, β-cell mass, and insulin secretion: their relationship during the fetal and neonatal periods
    Viviana Madrid
    CENEXA, Centro de Endocrinología Experimental y Aplicada UNLP, CONICET LA PLATA Centro Colaborador OPS OMS, Facultad de Ciencias Médicas UNLP, La Plata, Argentina
    Pancreas 42:422-8. 2013
  7. doi Intestinal adaptation and Reg gene expression induced by antidiabetic duodenal-jejunal bypass surgery in Zucker fatty rats
    Bing Li
    Fraser Laboratories for Diabetes Research, Department of Medicine, McGill University Health Centre, Montreal, Canada
    Am J Physiol Gastrointest Liver Physiol 304:G635-45. 2013
  8. ncbi Structure and expression of a novel rat RegIII gene
    Y Suzuki
    Department of Biochemistry, Tohoku University School of Medicine, Miyagi, Japan
    Gene 144:315-6. 1994
  9. ncbi Identification of a second rat pancreatitis-associated protein. Messenger RNA cloning, gene structure, and expression during acute pancreatitis
    J M Frigerio
    U 315 INSERM, Marseille, France
    Biochemistry 32:9236-41. 1993
  10. ncbi Coordinate regulation of PSP/reg and PAP isoforms as a family of secretory stress proteins in an animal model of chronic pancreatitis
    Daniel Bimmler
    Pancreatitis Research Laboratory, Department of Visceral and Transplantation Surgery, University Hospital, Zurich, Switzerland
    J Surg Res 118:122-35. 2004

Scientific Experts

  • Domenico Viterbo
  • Cathy M Mueller
  • Martin H Bluth
  • Michael E Zenilman
  • Yin Yao Lin
  • Richard Coffey
  • Bing Li
  • Viviana Madrid
  • Tamar Smith-Norowitz
  • Raj Wadgaonkar
  • Daniel Bimmler
  • Mitchell D Knutson
  • Hyeyoung Nam
  • Bárbara Maiztegui
  • Maria I Borelli
  • Coimbatore B Srikant
  • Héctor Del Zotto
  • Juan J Gagliardino
  • Zu hua Gao
  • Jun Li Liu
  • Yarong Lu
  • Luis E Flores
  • Theresa DiMaio
  • Gordon E Callender
  • Hazel Drew
  • Albert E Stanek
  • Eliane Angst
  • George Scheele
  • Aurel Perren
  • Severin Meili
  • Rudolf Ammann
  • Marc Schiesser
  • Rolf Graf
  • Y Suzuki
  • J M Frigerio
  • H Okamoto
  • M Unno
  • S Moriizumi
  • T Watanabe
  • H Miyashita
  • H Yonekura
  • V Keim
  • J C Dagorn
  • N J Dusetti
  • J L Iovanna

Detail Information

Publications11

  1. pmc Small-interference RNA gene knockdown of pancreatitis-associated proteins in rat acute pancreatitis
    Yin Yao Lin
    SUNY Downstate Medical Center, Brooklyn, NY 11203, USA
    Pancreas 36:402-10. 2008
    ..Here, we investigated the effect of a more stable inhibition of PAP using small-interference RNA gene knockdown in vitro and in an in vivo model of experimental pancreatitis...
  2. ncbi Pancreatitis-associated protein 2 modulates inflammatory responses in macrophages
    Domenico Viterbo
    Department of Surgery, Downstate Medical Center, State University of New York, Brooklyn, NY 11203, USA
    J Immunol 181:1948-58. 2008
    ..In the present study, we investigated the effect of PAP2 in the regulation of macrophage physiology...
  3. ncbi Mutational characterization of pancreatitis-associated protein 2 domains involved in mediating cytokine secretion in macrophages and the NF-kappaB pathway
    Domenico Viterbo
    Department of Surgery, Downstate Medical Center, State University of New York, Brooklyn, NY 11203, USA
    J Immunol 181:1959-68. 2008
    Pancreatitis-associated protein 2 (PAP2) is a member of the Reg3 gene family and is classified as a group 7 C-type lectin-like protein. In rats, each of the three PAP isoforms has independent immunologic functional effects on macrophages...
  4. pmc Administration of anti-Reg I and anti-PAPII antibodies worsens pancreatitis
    Domenico Viterbo
    Department of Surgery, SUNY Downstate Medical Center, Brooklyn, NY, USA
    JOP 10:15-23. 2009
    The regeneration protein family (Reg), which includes Reg I and PAPII, is expressed in pancreas acinar cells, and increases in acute pancreatitis...
  5. pmc Microarray analysis of rat pancreas reveals altered expression of Alox15 and regenerating islet-derived genes in response to iron deficiency and overload
    Richard Coffey
    Food Science and Human Nutrition Department, University of Florida, Gainesville, Florida, United States of America
    PLoS ONE 9:e86019. 2014
    ..In iron-overloaded pancreas, the most upregulated transcripts were Reg1a, Reg3a, and Reg3b belonging to the regenerating islet-derived gene (Reg) family...
  6. doi Islet neogenesis-associated protein (INGAP)-positive cell mass, β-cell mass, and insulin secretion: their relationship during the fetal and neonatal periods
    Viviana Madrid
    CENEXA, Centro de Endocrinología Experimental y Aplicada UNLP, CONICET LA PLATA Centro Colaborador OPS OMS, Facultad de Ciencias Médicas UNLP, La Plata, Argentina
    Pancreas 42:422-8. 2013
    ..To study the chronological appearance of pancreatic islet neogenesis-associated protein (INGAP)-positive cells and its correlation with the increase in β-cell mass and function in fetal and neonatal rats...
  7. doi Intestinal adaptation and Reg gene expression induced by antidiabetic duodenal-jejunal bypass surgery in Zucker fatty rats
    Bing Li
    Fraser Laboratories for Diabetes Research, Department of Medicine, McGill University Health Centre, Montreal, Canada
    Am J Physiol Gastrointest Liver Physiol 304:G635-45. 2013
    ....
  8. ncbi Structure and expression of a novel rat RegIII gene
    Y Suzuki
    Department of Biochemistry, Tohoku University School of Medicine, Miyagi, Japan
    Gene 144:315-6. 1994
    ..The cDNA encodes a 174-amino-acid (aa) RegIII protein with a 25-aa signal peptide. The RegIII gene spans 2.7 kb and consists of six exons and five introns...
  9. ncbi Identification of a second rat pancreatitis-associated protein. Messenger RNA cloning, gene structure, and expression during acute pancreatitis
    J M Frigerio
    U 315 INSERM, Marseille, France
    Biochemistry 32:9236-41. 1993
    ..abstract truncated at 250 words)..
  10. ncbi Coordinate regulation of PSP/reg and PAP isoforms as a family of secretory stress proteins in an animal model of chronic pancreatitis
    Daniel Bimmler
    Pancreatitis Research Laboratory, Department of Visceral and Transplantation Surgery, University Hospital, Zurich, Switzerland
    J Surg Res 118:122-35. 2004
    ..To further explore the regulation of these proteins, we investigated the male WBN/Kob rat, a model of pancreatic inflammatory and fibrotic disease similar to chronic pancreatitis...