Reg1a

Summary

Gene Symbol: Reg1a
Description: regenerating family member 1 alpha
Alias: LITHOST, RATLITHOST, RATRGPI, RGPI, Reg, Reg1, Rgp1, lithostathine, ICRF, PSP, PTP, islet cells regeneration factor, islet of Langerhans regenerating protein, pancreatic stone protein, pancreatic thread protein, regenerating islet-derived 1 alpha, regenerating islet-derived mouse homolog 1, regeneration protein, lithostatin, pancreatic stone protein
Species: rat

Top Publications

  1. ncbi Mutations of RegIalpha are associated with enterochromaffin-like cell tumor development in patients with hypergastrinemia
    A D Higham
    The Physiological Laboratory, University of Liverpool, Liverpool, England
    Gastroenterology 116:1310-8. 1999
  2. ncbi A novel gene activated in regenerating islets
    K Terazono
    Department of Biochemistry, Tohoku University School of Medicine, Miyagi, Japan
    J Biol Chem 263:2111-4. 1988
  3. pmc Pancreatic reg I binds MKP-1 and regulates cyclin D in pancreatic-derived cells
    Cathy M Mueller
    Department of Surgery, SUNY Downstate Medical Center, Brooklyn, New York 11203, USA
    J Surg Res 150:137-43. 2008
  4. ncbi PAP I interacts with itself, PAP II, PAP III, and lithostathine/regIalpha
    H Bodeker
    Laboratoire de Recherche de Physiologie et Pathologie Digestives, INSERM U 315, Marseille, France
    Mol Cell Biol Res Commun 2:150-4. 1999
  5. ncbi Identification of a receptor for reg (regenerating gene) protein, a pancreatic beta-cell regeneration factor
    S Kobayashi
    Department of Biochemistry, Tohoku University Graduate School of Medicine, 2 1 Seiryo machi, Aoba ku, Sendai 980 8575, Miyagi, Japan
    J Biol Chem 275:10723-6. 2000
  6. ncbi Neutrophil chemoattractant 2 beta regulates expression of the Reg gene in injured gastric mucosa in rats
    H Kazumori
    Second Department of Internal Medicine, Shimane Medical University, Izumo, Japan
    Gastroenterology 119:1610-22. 2000
  7. ncbi Immunoreactive forms of pancreatic stone protein in six mammalian species
    J P Bernard
    Unité de Recherches de Physiologie et Pathologie Digestives, INSERM U 315, Marseille, France
    Pancreas 6:162-7. 1991
  8. ncbi Human REG I gene is up-regulated in intrahepatic cholangiocarcinoma and its precursor lesions
    K Harada
    Department of Pathology II, Kanazawa University School of Medicine, Kanazawa, Japan
    Hepatology 33:1036-42. 2001
  9. ncbi Secretory apparatus assessed by analysis of pancreatic secretory stress protein expression in a rat model of chronic pancreatitis
    Severin Meili
    Pancreatitis Research Laboratory DL 36, Department of Visceral and Transplant Surgery, University Hospital Zurich, 8091, Zurich, Switzerland
    Cell Tissue Res 312:291-9. 2003
  10. ncbi Insights into the mechanisms of gastric adaptation to aspirin-induced injury: a role for regenerating protein but not trefoil peptides
    Barbara M Alderman
    University of Melbourne, Department of Medicine, Western Hospital, Footscray, Victoria, Australia
    Lab Invest 83:1415-25. 2003

Scientific Experts

  • M E Zenilman
  • Tatsuya Kiji
  • Kyoichi Adachi
  • Cathy M Mueller
  • Hiroshi Okamoto
  • H Okamoto
  • Hiroyo Ota
  • Shin Takasawa
  • Domenico Viterbo
  • Martin H Bluth
  • H Fukui
  • Richard Coffey
  • Asako Itaya-Hironaka
  • Tomoko Miyaoka
  • Akiyo Yamauchi
  • Kiyomi Yoshimoto
  • Adrian O'Hara
  • Sumiyo Sakuramoto-Tsuchida
  • Bing Li
  • Kei Nakagawa
  • Isabelle Acquatella-Tran Van Ba
  • T Chiba
  • Jin Jin Chen
  • S Takasawa
  • Daniel Bimmler
  • Severin Meili
  • Jingshu Wang
  • Didier Sanchez
  • T Kimura
  • Martin Bluth
  • Aurel Perren
  • Marc Schiesser
  • Rolf Graf
  • Barbara M Alderman
  • Y Kinoshita
  • Mitchell D Knutson
  • Hyeyoung Nam
  • Yasunori Kadowaki
  • Andrea Varro
  • Kan ichi Nakagawara
  • Rod Dimaline
  • Michiaki Unno
  • Koji Nata
  • Hiroki Tsujinaka
  • Coimbatore B Srikant
  • Maiko Takeda
  • Yarong Lu
  • Shinji Tamaki
  • Hiroshi Kimura
  • Zu hua Gao
  • Alice Howarth
  • Takanori Fujimura
  • Jun Li Liu
  • R Graf
  • Florence François
  • Michèle Silhol
  • Jean Michel Verdier
  • Anne Marcilhac
  • Stephane Marchal
  • Coline Lleres
  • K Harada
  • Françoise Trousse
  • Yves Benyamin
  • Bernard Michel
  • Xiao Fang Li
  • Ren Wang
  • Rui Liang Wang
  • S Kobayashi
  • T Watanabe
  • H Kazumori
  • Souichi Koyota
  • Gordon E Callender
  • Masami Kawagoe
  • Tamar Smith-Norowitz
  • S Fujii
  • Yasuharu Ueno
  • Xiaoping Zhou
  • H Yamagishi
  • H Kawamata
  • Yukio Koizumi
  • S Tomita
  • Theresa DiMaio
  • A Sekikawa
  • Toshihiro Sugiyama
  • Y Imai
  • J Imura
  • T Fujimori
  • Li Ma
  • K Ichikawa
  • A D Higham

Detail Information

Publications41

  1. ncbi Mutations of RegIalpha are associated with enterochromaffin-like cell tumor development in patients with hypergastrinemia
    A D Higham
    The Physiological Laboratory, University of Liverpool, Liverpool, England
    Gastroenterology 116:1310-8. 1999
    The RegIalpha gene (Reg) encodes a secretory protein proposed to regulate islet beta-cell and gastric mucous cell growth. Reg is expressed in rat gastric enterochromaffin-like (ECL) cells...
  2. ncbi A novel gene activated in regenerating islets
    K Terazono
    Department of Biochemistry, Tohoku University School of Medicine, Miyagi, Japan
    J Biol Chem 263:2111-4. 1988
    ..We also found that a human pancreas-derived cDNA library contained a homologue to the gene...
  3. pmc Pancreatic reg I binds MKP-1 and regulates cyclin D in pancreatic-derived cells
    Cathy M Mueller
    Department of Surgery, SUNY Downstate Medical Center, Brooklyn, New York 11203, USA
    J Surg Res 150:137-43. 2008
    The pancreatic regenerating (reg I) gene and its protein product are derived from acinar cells and are mitogenic to beta- and ductal cells. We studied the mechanism of this mitogenic response.
  4. ncbi PAP I interacts with itself, PAP II, PAP III, and lithostathine/regIalpha
    H Bodeker
    Laboratoire de Recherche de Physiologie et Pathologie Digestives, INSERM U 315, Marseille, France
    Mol Cell Biol Res Commun 2:150-4. 1999
    PAP I, PAP II, PAP III, and lithostathine/regIalpha are members of a multigenic family of proteins expressed in several tissues...
  5. ncbi Identification of a receptor for reg (regenerating gene) protein, a pancreatic beta-cell regeneration factor
    S Kobayashi
    Department of Biochemistry, Tohoku University Graduate School of Medicine, 2 1 Seiryo machi, Aoba ku, Sendai 980 8575, Miyagi, Japan
    J Biol Chem 275:10723-6. 2000
    b>Reg (regenerating gene) was isolated as a gene specifically expressed in regenerating islets (Terazono, K., Yamamoto, H., Takasawa, S., Shiga, K., Yonemura, Y., Tochino, Y., and Okamoto, H. (1988) J. Biol. Chem. 263, 2111-2114)...
  6. ncbi Neutrophil chemoattractant 2 beta regulates expression of the Reg gene in injured gastric mucosa in rats
    H Kazumori
    Second Department of Internal Medicine, Shimane Medical University, Izumo, Japan
    Gastroenterology 119:1610-22. 2000
    Regenerating (Reg) protein has a trophic effect on gastric mucosal cells. We have shown that Reg gene expression is increased in enterochromaffin-like (ECL) cells during the healing of damaged gastric mucosa around mucosal erosion...
  7. ncbi Immunoreactive forms of pancreatic stone protein in six mammalian species
    J P Bernard
    Unité de Recherches de Physiologie et Pathologie Digestives, INSERM U 315, Marseille, France
    Pancreas 6:162-7. 1991
    Secretory forms of the pancreatic stone protein (PSP S, Mr 17, 500-22,000) have been purified from human pancreatic juice. PSP S are inhibitors of CaCO3 crystal growth...
  8. ncbi Human REG I gene is up-regulated in intrahepatic cholangiocarcinoma and its precursor lesions
    K Harada
    Department of Pathology II, Kanazawa University School of Medicine, Kanazawa, Japan
    Hepatology 33:1036-42. 2001
    The Reg I gene (regenerating gene) and its product (Reg protein) are a regenerating and/or proliferating factor(s) of pancreatic islet cells...
  9. ncbi Secretory apparatus assessed by analysis of pancreatic secretory stress protein expression in a rat model of chronic pancreatitis
    Severin Meili
    Pancreatitis Research Laboratory DL 36, Department of Visceral and Transplant Surgery, University Hospital Zurich, 8091, Zurich, Switzerland
    Cell Tissue Res 312:291-9. 2003
    ..proteins (SSP) are a family of proteins including isoforms of pancreatitis-associated protein (PAP) and pancreatic stone protein (PSP/reg). In vitro exposure to trypsin results in the formation of insoluble fibrillar structures...
  10. ncbi Insights into the mechanisms of gastric adaptation to aspirin-induced injury: a role for regenerating protein but not trefoil peptides
    Barbara M Alderman
    University of Melbourne, Department of Medicine, Western Hospital, Footscray, Victoria, Australia
    Lab Invest 83:1415-25. 2003
    ....
  11. ncbi A family of 16-kDa pancreatic secretory stress proteins form highly organized fibrillar structures upon tryptic activation
    R Graf
    Pancreatitis Research Laboratory, Department of Visceral Surgery, University Hospital, Zurich, 8091, Switzerland
    J Biol Chem 276:21028-38. 2001
    ..PAP I and PAP III) resulted in conversion of 16-kDa soluble proteins into 14-kDa soluble isoforms (pancreatic thread protein and pancreatitis-associated thread protein, respectively) that rapidly polymerize into insoluble ..
  12. pmc Involvement of REG Ialpha protein in the regeneration of ductal epithelial cells in the minor salivary glands of patients with Sjögren's syndrome
    T Kimura
    Department of Surgical and Molecular Pathology, Dokkyo University School of Medicine, Mibu, Shimotsuga, Tochigi, Japan
    Clin Exp Immunol 155:16-20. 2009
    The regenerating gene (Reg) was originally isolated from regenerating rat pancreatic islets and revealed recently to constitute a multi-gene family in humans...
  13. pmc Administration of anti-Reg I and anti-PAPII antibodies worsens pancreatitis
    Domenico Viterbo
    Department of Surgery, SUNY Downstate Medical Center, Brooklyn, NY, USA
    JOP 10:15-23. 2009
    The regeneration protein family (Reg), which includes Reg I and PAPII, is expressed in pancreas acinar cells, and increases in acute pancreatitis...
  14. doi Bifidobacterium longum supplementation improved high-fat-fed-induced metabolic syndrome and promoted intestinal Reg I gene expression
    Jin Jin Chen
    Children Health Care Center, Shanghai Children s Hospital Shanghai Jiaotong University, No 24 Ln 1400 West Beijing Road, Shanghai, China
    Exp Biol Med (Maywood) 236:823-31. 2011
    ..The expression of intestinal REG (regenerating) family proteins which are widely involved in inflammatory bowel disease and diabetes are still ..
  15. doi Prevention of Reg I-induced β-cell apoptosis by IL-6/dexamethasone through activation of HGF gene regulation
    Kei Nakagawa
    Department of Advanced Biological Sciences for Regeneration Kotobiken Medical Laboratories, Tohoku University Graduate School of Medicine, Sendai 980 8575, Miyagi, Japan Department of Surgery, Tohoku University Graduate School of Medicine, Sendai 980 8575, Miyagi, Japan
    Biochim Biophys Acta 1833:2988-95. 2013
    b>Reg (regenerating gene) product, Reg protein, is induced in pancreatic β-cells and acts as autocrine/paracrine growth factor for regeneration via the cell surface Reg receptor...
  16. doi Pancreatic β cell proliferation by intermittent hypoxia via up-regulation of Reg family genes and HGF gene
    Hiroyo Ota
    Second Department of Internal Medicine, Nara Medical University, Kashihara 634 8521, Nara, Japan
    Life Sci 93:664-72. 2013
    ..Although accumulating evidence suggests the associations between sleep apnea syndrome (SAS) and type 2 diabetes, the direct effect of intermittent hypoxia (IH) on pancreatic β cell proliferation remains a missing piece of the puzzle...
  17. pmc Microarray analysis of rat pancreas reveals altered expression of Alox15 and regenerating islet-derived genes in response to iron deficiency and overload
    Richard Coffey
    Food Science and Human Nutrition Department, University of Florida, Gainesville, Florida, United States of America
    PLoS ONE 9:e86019. 2014
    ..In iron-overloaded pancreas, the most upregulated transcripts were Reg1a, Reg3a, and Reg3b belonging to the regenerating islet-derived gene (Reg) family...
  18. ncbi Regenerating gene protein may mediate gastric mucosal proliferation induced by hypergastrinemia in rats
    H Fukui
    Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Gastroenterology 115:1483-93. 1998
    Regenerating gene (Reg) has been isolated from rat regenerating pancreatic islets, and Reg protein is mitogenic to islet cells...
  19. ncbi Effect of reg protein on rat pancreatic ductal cells
    M E Zenilman
    Department of Surgery, Albert Einstein College of Medicine, Montefiore Medical Center, Bronx, New York 10461, USA
    Pancreas 17:256-61. 1998
    The pancreatic regenerating gene (reg I) is expressed in the exocrine pancreas and is involved in islet regeneration. Reg I protein has been shown to be mitogenic to beta- and ductal cell lines, but not mature islets...
  20. ncbi Amelioration of diabetes in nonobese diabetic mice with advanced disease by linomide-induced immunoregulation combined with Reg protein treatment
    D J Gross
    Department of Endocrinology, Hebrew University Hadassah Medical Center, Jerusalem, Israel
    Endocrinology 139:2369-74. 1998
    ..b>Reg protein, the gene product of a complementary DNA isolated from a regenerating rat islet library, has been ..
  21. ncbi Reg gene expression is increased in rat gastric enterochromaffin-like cells following water immersion stress
    M Asahara
    Division of Gerontology, Department of Internal Medicine, Kobe University School of Medicine, Kobe, Japan
    Gastroenterology 111:45-55. 1996
    b>Reg gene has been isolated from regenerating rat pancreatic islets, and subsequent studies have shown a trophic effect of Reg protein on islet cells. However, little is known about the role of Reg protein in the stomach...
  22. ncbi Increased expression of a regenerating (reg) gene protein in neonatal rat pancreas treated with streptozotocin
    T Ohno
    2nd Department of Internal Medicine, Gunma University School of Medicine, Japan
    Endocr J 42:649-53. 1995
    We examined the expression of reg protein in neonatal rat pancreas treated with streptozotocin (STZ) by means of the immunohistochemical technique and northern blotting...
  23. pmc Pancreatic beta-cell replication and amelioration of surgical diabetes by Reg protein
    T Watanabe
    Department of Biochemistry, Tohoku University School of Medicine, Sendai, Japan
    Proc Natl Acad Sci U S A 91:3589-92. 1994
    We previously isolated from a rat regenerating islet cDNA library a gene named Reg, which is expressed in regenerating islets but is not expressed in normal islets...
  24. ncbi Complete nucleotide sequence of human reg gene and its expression in normal and tumoral tissues. The reg protein, pancreatic stone protein, and pancreatic thread protein are one and the same product of the gene
    T Watanabe
    Department of Biochemistry, Tohoku University School of Medicine, Miyagi, Japan
    J Biol Chem 265:7432-9. 1990
    ..1989) Biochim. Biophys. Acta 994, 281-284) and the partially determined 45-amino acid sequence of pancreatic thread protein (Gross, J., Carlson, R. I., Brauer, A. W., Margolies, M. N., Warshaw, A. L., and Wands, J. R. (1985) J...
  25. pmc Enhanced expression of an exocrine pancreatic protein in Alzheimer's disease and the developing human brain
    S M de la Monte
    Molecular Hepatology Laboratory, Massachusetts Alzheimer s Disease Research Center, Charlestown 02114
    J Clin Invest 86:1004-13. 1990
    b>Pancreatic thread protein (PTP) is a major exocrine secretory protein that in vitro forms filamentous bundles reminiscent of the paired helical filaments of Alzheimer's disease (AD)...
  26. ncbi The human pancreatic stone protein
    A De caro
    Unité de Recherches de Pathologie Digestive, INSERM U31, Marseille, France
    Biochimie 70:1209-14. 1988
    ..of stones, to which is associated an organic matrix consisting primarily of one protein of Mr 14,000, the pancreatic stone protein or PSP...
  27. ncbi Age-related changes in peptide-23/pancreatitis-associated protein and pancreatic stone protein/reg gene expression in the rat and regulation by growth hormone-releasing hormone
    C Chakraborty
    Department of Physiology, University of Manitoba, Winnipeg, Canada
    Endocrinology 136:1843-9. 1995
    ..We examined the expression of peptide-23/PAP and a structurally related protein, pancreatic stone protein (PSP/reg), in the rat gastrointestinal tract...
  28. pmc The role of proteasome beta subunits in gastrin-mediated transcription of plasminogen activator inhibitor-2 and regenerating protein1
    Adrian O'Hara
    Department of Cellular and Molecular Physiology, Institute of Translational Medicine, University of Liverpool, Liverpool, United Kingdom
    PLoS ONE 8:e59913. 2013
    ..by regulating expression of genes such as plasminogen activator inhibitor 2 (PAI-2) and regenerating protein 1 (Reg1)...
  29. doi Intestinal adaptation and Reg gene expression induced by antidiabetic duodenal-jejunal bypass surgery in Zucker fatty rats
    Bing Li
    Fraser Laboratories for Diabetes Research, Department of Medicine, McGill University Health Centre, Montreal, Canada
    Am J Physiol Gastrointest Liver Physiol 304:G635-45. 2013
    ..With the use of immunohistochemistry, Reg1, -3α, and -3β were normally expressed in intestinal mucosa...
  30. pmc Regenerating islet-derived 1α (Reg-1α) protein is new neuronal secreted factor that stimulates neurite outgrowth via exostosin Tumor-like 3 (EXTL3) receptor
    Isabelle Acquatella-Tran Van Ba
    University Montpellier 2, F 34095 Montpellier, France, INSERM, U710, F 34095 Montpellier, France
    J Biol Chem 287:4726-39. 2012
    Regenerating islet-derived 1α (Reg-1α)/lithostathine, a member of a family of secreted proteins containing a C-type lectin domain, is expressed in various organs and plays a role in proliferation, differentiation, inflammation, and ..
  31. ncbi Rat pancreatic stone protein messenger RNA. Abundant expression in mature exocrine cells, regulation by food content, and sequence identity with the endocrine reg transcript
    S Rouquier
    Unité 315 de l Institut National de la Santé et de la Recherche Médicale, Marseille, France
    J Biol Chem 266:786-91. 1991
    We used a cDNA encoding the human pancreatic stone protein (PSP-S), the secretory inhibitor of CaCO3 crystal growth, as a probe for cloning rat PSP-S messenger RNA...
  32. ncbi The Reg gene family and Reg proteins: with special attention to the regeneration of pancreatic beta-cells
    H Okamoto
    Department of Biochemistry, Tohoku University School of Medicine, 2 1 Seiryo machi, Aoba ku, Sendai 980 8575, Japan
    J Hepatobiliary Pancreat Surg 6:254-62. 1999
    ..In screening the regenerating islet-derived cDNA library, we found a novel gene and named it Reg (i.e., regenerating gene)...
  33. pmc Pancreatic regenerating gene I and acinar cell differentiation: influence on cellular lineage
    Didier Sanchez
    Department of Surgery, SUNY Downstate Medical Center, Brooklyn, NY 11203, USA
    Pancreas 38:572-7. 2009
    Pancreatic regenerating gene I (reg I) has been implicated in cellular differentiation...
  34. doi Expression and localization of regenerating gene I in a rat liver regeneration model
    Jingshu Wang
    Department of Biochemistry, Akita University School of Medicine, 1 1 1 Hondo, Akita 010 8543, Japan
    Biochem Biophys Res Commun 380:472-7. 2009
    Regenerating gene (Reg) I has been identified as a regenerative/proliferative factor for pancreatic islet cells...
  35. ncbi Rapid PCR cloning and sequence determination of the rat lithostathine gene
    N J Dusetti
    U 315 INSERM, Marseille, France
    Biochim Biophys Acta 1174:99-102. 1993
    The rat lithostathine gene was isolated from a genomic library using a rapid screening procedure involving PCR amplification. It was characterized over 2.7 kbp of gene sequence and 2.43 kbp of 5'-flanking sequence...
  36. pmc Pancreatic regenerating protein I in chronic pancreatitis and aging: implications for new therapeutic approaches to diabetes
    Martin Bluth
    Department of Surgery, SUNY Downstate Medical Center, Brooklyn, NY 11202, USA
    Pancreas 37:386-95. 2008
    We investigated the relationship of pancreatic regenerating protein (reg) in models of acinar cell atrophy and aging, and the effect of reg I protein replacement on glucose tolerance.
  37. ncbi Characterization of the 5'-regulatory region of rat Reg I gene
    H Miyashita
    Department of Biochemistry, Tohoku University School of Medicine, Miyagi, Japan
    Biochim Biophys Acta 1219:241-3. 1994
    We report here the characterization of the 5'-regulatory region of rat Reg I gene encoding a growth stimulating factor for pancreatic beta-cells...
  38. pmc Pancreatic regenerating protein (reg I) and reg I receptor mRNA are upregulated in rat pancreas after induction of acute pancreatitis
    Martin H Bluth
    Department of Surgery, State University of New York Downstate Medical Center, Brooklyn, New York, USA
    World J Gastroenterol 12:4511-6. 2006
    Pancreatic regenerating protein (reg I) stimulates pancreatic regeneration after pancreatectomy and is mitogenic to ductal and beta-cells. This suggests that reg I and its receptor may play a role in recovery after pancreatic injury...
  39. ncbi Activation of regenerating gene Reg in rat and human hearts in response to acute stress
    Tatsuya Kiji
    Dept of Thoracic and Cardiovascular Surgery, Nara Medical Univ School of Medicine, 840 Shijo Cho, Kashihara, Nara 634 8522, Japan
    Am J Physiol Heart Circ Physiol 289:H277-84. 2005
    Recently, the regenerating gene (Reg) has been documented to play an important role in various regenerating tissues, but it is unknown whether the Reg gene could be activated in the heart...
  40. ncbi Coordinate regulation of PSP/reg and PAP isoforms as a family of secretory stress proteins in an animal model of chronic pancreatitis
    Daniel Bimmler
    Pancreatitis Research Laboratory, Department of Visceral and Transplantation Surgery, University Hospital, Zurich, Switzerland
    J Surg Res 118:122-35. 2004
    PSP/reg and PAP are secretory stress proteins (SSP) and may be part of a protective mechanism. They share structural homologies and form insoluble fibrils after tryptic activation...
  41. ncbi Reg protein is overexpressed in gastric cancer cells, where it activates a signal transduction pathway that converges on ERK1/2 to stimulate growth
    Yasunori Kadowaki
    Second Department of Internal Medicine, Shimane Medical University, Izumo 693 8501, Japan
    FEBS Lett 530:59-64. 2002
    b>Reg is a growth factor with mitogenic effects on pancreatic beta cells and gastric stem cells. To date, there has been no information available on Reg-mediated intracellular signal transduction pathways...