Rarb

Summary

Gene Symbol: Rarb
Description: retinoic acid receptor, beta
Alias: retinoic acid receptor beta
Species: rat

Top Publications

  1. ncbi International Union of Pharmacology. LX. Retinoic acid receptors
    Pierre Germain
    Centre National de la Recherche Scientifique Institut National de la Santé et de la Recherche Médicale Université Louis Pasteur, Illkirch, Communaute Urbaine de Strasbourg, France
    Pharmacol Rev 58:712-25. 2006
  2. ncbi Neuritogenic activity of trichostatin A in adult rat retinal ganglion cells through acetylation of histone H3 lysine 9 and RARβ induction
    Yoshiki Koriyama
    Department of Molecular Neurobiology, Graduate School of Medicine, Kanazawa University, Japan
    J Pharmacol Sci 124:112-6. 2014
  3. pmc Neuronal RARβ Signaling Modulates PTEN Activity Directly in Neurons and via Exosome Transfer in Astrocytes to Prevent Glial Scar Formation and Induce Spinal Cord Regeneration
    Maria B Goncalves
    The Wolfson Centre for Age Related Diseases, King s College London, Guy s Campus, London SE1 1UL, United Kingdom
    J Neurosci 35:15731-45. 2015
  4. doi High dietary fat-induced obesity in Wistar rats and type 2 diabetes in nonobese Goto-Kakizaki rats differentially affect retinol binding protein 4 expression and vitamin A metabolism
    Tomomi Shirai
    Department of Applied Biology and Chemistry, Faculty of Applied Bioscience, Tokyo University of Agriculture, 1 1 1 Sakuragaoka, Setagaya Ku, Tokyo 156 8502, Japan
    Nutr Res 36:262-70. 2016
  5. ncbi Study of retinoic acid effect upon retinoic acid receptors beta (RAR-beta) in C6 cultured glioma cells
    P Reboul
    Laboratoire de Biochimie Générale et Médicale, INSERM CNRS U 189 Faculté de Médecine Lyon Sud, Oullins, France
    Biochem Mol Biol Int 36:1097-105. 1995
  6. ncbi Regulation of alpha 2(I) collagen expression in stellate cells by retinoic acid and retinoid X receptors through interactions with their cofactors
    Lan Wang
    Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Arch Biochem Biophys 428:92-8. 2004
  7. ncbi Vitamin A regulation of gene expression: molecular mechanism of a prototype gene
    Mary M McGrane
    Department of Nutritional Sciences, The University of Connecticut, Storrs, CT 06269, USA
    J Nutr Biochem 18:497-508. 2007
  8. doi Sequential RARbeta and alpha signalling in vivo can induce adult forebrain neural progenitor cells to differentiate into neurons through Shh and FGF signalling pathways
    Maria Beatriz C V Goncalves
    The Wolfson Centre for Age Related Diseases, King s College London, Guy s Campus, London, UK
    Dev Biol 326:305-13. 2009
  9. pmc Dynamic and combinatorial control of gene expression by nuclear retinoic acid receptors (RARs)
    Cecile Rochette-Egly
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, Department of Functional Genomics, INSERM U596, CNRS UMR7104, Universite Louis Pasteur de Strasbourg, Strasbourg, France
    Nucl Recept Signal 7:e005. 2009
  10. doi Retinoic acid regulates myelin formation in the peripheral nervous system
    Maria Jesus Latasa
    Department of Endocrine and Nervous System Physiopathology, Instituto de Investigaciones Biomedicas, Universidad Autonoma de Madrid, Madrid, Spain
    Glia 58:1451-64. 2010

Research Grants

Scientific Experts

  • Pierre Germain
  • Cecile Rochette-Egly
  • GAIL S contact PRINS
  • Mary M McGrane
  • Tomomi Shirai
  • Maria B Goncalves
  • Yoshiki Koriyama
  • Jonathan P T Corcoran
  • Xuan Zhang
  • Maria Jesus Latasa
  • Maria Beatriz C V Goncalves
  • Tomoko Tateya
  • Lan Wang
  • Ken ichi Kobayashi
  • Yuta Shichi
  • Yuji Yamamoto
  • Tadasu Furusho
  • Tsukasa Suzuki
  • Miyuki Sato
  • Tadahiro Tadokoro
  • Yuri Tanioka
  • Toru Ota
  • Maria Angeria
  • John Grist
  • Marten Risling
  • Earl Clarke
  • Tony Malmqvist
  • Chantal J Hubens
  • Diogo Trigo
  • Peter Damberg
  • Thomas P Carlstedt
  • Carl Hobbs
  • Satoru Kato
  • Kayo Sugitani
  • Kazuhiro Ogai
  • Ting Yu Li
  • You xue Liu
  • Jie Chen
  • Ke Chen
  • Ping Qu
  • Alejandra Moran-Gonzalez
  • Ana Aranda
  • Jose Miguel Cosgaya
  • Mario Ituero
  • Siobhán Connor
  • Stephen McMahon
  • Stephen L Minger
  • Malcolm Maden
  • Marta Agudo
  • Diane M Bless
  • Rebecca Lynn Surles
  • Sherry Tanumihardjo
  • Ichiro Tateya
  • James J Potter
  • Mei Tang
  • Esteban Mezey
  • Lynda Rennie Tankersley
  • P Reboul
  • P Broquet
  • P George
  • P Louisot
  • M G Mattei
  • B Vennstrom
  • M Q Islam
  • S Ingvarsson
  • A Krust
  • P Kautner
  • P Chambon
  • A Zelent
  • G Levan
  • M Riviere

Detail Information

Publications14

  1. ncbi International Union of Pharmacology. LX. Retinoic acid receptors
    Pierre Germain
    Centre National de la Recherche Scientifique Institut National de la Santé et de la Recherche Médicale Université Louis Pasteur, Illkirch, Communaute Urbaine de Strasbourg, France
    Pharmacol Rev 58:712-25. 2006
    ..This review summarizes the considerable amount of knowledge generated on these receptors...
  2. ncbi Neuritogenic activity of trichostatin A in adult rat retinal ganglion cells through acetylation of histone H3 lysine 9 and RARβ induction
    Yoshiki Koriyama
    Department of Molecular Neurobiology, Graduate School of Medicine, Kanazawa University, Japan
    J Pharmacol Sci 124:112-6. 2014
    ..Furthermore, we demonstrated that a histone deacetylase inhibitor, trichostatin A, induced axonal regeneration of adult rat RGCs through RARβ induction. ..
  3. pmc Neuronal RARβ Signaling Modulates PTEN Activity Directly in Neurons and via Exosome Transfer in Astrocytes to Prevent Glial Scar Formation and Induce Spinal Cord Regeneration
    Maria B Goncalves
    The Wolfson Centre for Age Related Diseases, King s College London, Guy s Campus, London SE1 1UL, United Kingdom
    J Neurosci 35:15731-45. 2015
    ..The dual effect of RARβ signaling, both neuronal and neuronal-glial, results in axonal regeneration into the SC after dorsal root neurotmesis. Targeting this pathway may open new avenues for the treatment of SCIs...
  4. doi High dietary fat-induced obesity in Wistar rats and type 2 diabetes in nonobese Goto-Kakizaki rats differentially affect retinol binding protein 4 expression and vitamin A metabolism
    Tomomi Shirai
    Department of Applied Biology and Chemistry, Faculty of Applied Bioscience, Tokyo University of Agriculture, 1 1 1 Sakuragaoka, Setagaya Ku, Tokyo 156 8502, Japan
    Nutr Res 36:262-70. 2016
    ..In particular, our data indicate that renal retinoic acid production might represent an important target for the treatment of type 2 diabetes mellitus. ..
  5. ncbi Study of retinoic acid effect upon retinoic acid receptors beta (RAR-beta) in C6 cultured glioma cells
    P Reboul
    Laboratoire de Biochimie Générale et Médicale, INSERM CNRS U 189 Faculté de Médecine Lyon Sud, Oullins, France
    Biochem Mol Biol Int 36:1097-105. 1995
    ..These results suggest that retinoic acid treatment of C6 cells led to a partial differentiation, the enhancement of the heavy form of RAR-beta being a marker of this phenomenon...
  6. ncbi Regulation of alpha 2(I) collagen expression in stellate cells by retinoic acid and retinoid X receptors through interactions with their cofactors
    Lan Wang
    Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Arch Biochem Biophys 428:92-8. 2004
    ..acid (RA) suppresses alpha 2(I) collagen expression in hepatic stellate cells through the binding of retinoic acid receptor beta (RAR beta) and retinoid X receptor alpha (RXR alpha) to RA response elements (RAREs) in the alpha 2(I) ..
  7. ncbi Vitamin A regulation of gene expression: molecular mechanism of a prototype gene
    Mary M McGrane
    Department of Nutritional Sciences, The University of Connecticut, Storrs, CT 06269, USA
    J Nutr Biochem 18:497-508. 2007
    ....
  8. doi Sequential RARbeta and alpha signalling in vivo can induce adult forebrain neural progenitor cells to differentiate into neurons through Shh and FGF signalling pathways
    Maria Beatriz C V Goncalves
    The Wolfson Centre for Age Related Diseases, King s College London, Guy s Campus, London, UK
    Dev Biol 326:305-13. 2009
    ....
  9. pmc Dynamic and combinatorial control of gene expression by nuclear retinoic acid receptors (RARs)
    Cecile Rochette-Egly
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, Department of Functional Genomics, INSERM U596, CNRS UMR7104, Universite Louis Pasteur de Strasbourg, Strasbourg, France
    Nucl Recept Signal 7:e005. 2009
    ..Here we will review these mechanisms, focusing on how kinase signaling and the proteasome pathway cooperate to influence the dynamics of RAR transcriptional activity...
  10. doi Retinoic acid regulates myelin formation in the peripheral nervous system
    Maria Jesus Latasa
    Department of Endocrine and Nervous System Physiopathology, Instituto de Investigaciones Biomedicas, Universidad Autonoma de Madrid, Madrid, Spain
    Glia 58:1451-64. 2010
    ..At the same time, through a RAR-dependent mechanism, RA downregulates myelin-associated glycoprotein, which also contributes to the dysmyelinating effect of the retinoid...
  11. doi Effect of marginal vitamin A deficiency during pregnancy on retinoic acid receptors and N-methyl-D-aspartate receptor expression in the offspring of rats
    Xuan Zhang
    Child Health Care, Children s Hospital, Chongqing Medical University, Chongqing 400014, PR China
    J Nutr Biochem 22:1112-20. 2011
    ..Our data suggested that vitamin A deficiency in pregnancy may affect the postnatal expression of RARα and NR1, affecting learning and memory function in the hippocampus and synaptic plasticity of the calcium signaling pathway...
  12. ncbi Chromosomal assignment of retinoic acid receptor (RAR) genes in the human, mouse, and rat genomes
    M G Mattei
    INSERM U 242, Hopital d Enfants de la Timone, Centre de Genetique Medicale, Marseille, France
    Genomics 10:1061-9. 1991
    ..1:RARA) and 3 (band p24:RARB)...
  13. ncbi Retinoic acid receptors and retinoids are up-regulated in the developing and adult rat prostate by neonatal estrogen exposure
    Gail S Prins
    Department of Urology, College of Medicine, University of Illinois, Chicago, Illinois 60612, USA
    Endocrinology 143:3628-40. 2002
    ..Thus, we hypothesize that alterations in morphogenesis as well as dysplasia in the adult prostate may be mediated in part through augmentation of transcriptional signals in the retinoid pathway...
  14. ncbi Roles of vitamin A and macula flava in maintaining vocal folds
    Tomoko Tateya
    Department of Otolaryngology Head and Neck Surgery, Graduate School of Medicine, Kyoto University, Japan
    Ann Otol Rhinol Laryngol 117:65-73. 2008
    ..The purpose of this study was to investigate the roles of vitamin A in vocal folds...

Research Grants2

  1. ESTROGEN IMPRINTING OF PROSTATE GLAND VIA METHYLATON
    Gail Prins; Fiscal Year: 2005
    ....
  2. Development Estrogenization of the Rat Prostate Gland
    Gail S Prins; Fiscal Year: 2010
    ..Results will further define the mechanisms of estrogen's actions on the prostate gland during early development and lead to a better understanding of the hormonal and developmental basis for abnormal prostate growth with aging...