Ptn

Summary

Gene Symbol: Ptn
Description: pleiotrophin
Alias: HARP, Hbnf, pleiotrophin, HB-GAM, HBBM, HBGF-8, OSF-1, Pleiotrophin (Heparine binding factor, Hbnf, in the mouse), heparin affine regulatory peptide, heparin binding factor, heparin-binding brain mitogen, heparin-binding growth factor 8, heparin-binding growth-associated molecule, heparin-binding neurotrophic factor, heparin-binding neutrophic factor, osteoblast-specific factor 1
Species: rat

Top Publications

  1. doi Neuroglycan C, a brain-specific chondroitin sulfate proteoglycan, interacts with pleiotrophin, a heparin-binding growth factor
    Keiko Nakanishi
    Department of Perinatology, Institute for Developmental Research, Aichi Human Service Center, Kasugai, Aichi, Japan
    Neurochem Res 35:1131-7. 2010
  2. ncbi Basic FGF and FGF receptor 1 are expressed in microglia during experimental autoimmune encephalomyelitis: temporally distinct expression of midkine and pleiotrophin
    X Liu
    Laboratory of Experimental Neuropathology, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA
    Glia 24:390-7. 1998
  3. ncbi Upregulation of the angiogenic factor heparin affin regulatory peptide by progesterone in rat uterus
    P E Milhiet
    Laboratoire de Recherche sur la Croissance Cellulaire, la Réparation et la Régénération Tissulaires CRRET, CNRS UPRESA 7053, Universite Paris XII, Creteil, France
    J Endocrinol 158:389-99. 1998
  4. ncbi Immunohistochemical localization of pleiotrophin and midkine in the lingual epithelium of the adult rat
    S Wakisaka
    Department of Oral Anatomy and Developmental Biology, Osaka University Faculty of Dentistry, Japan
    Arch Histol Cytol 61:475-80. 1998
  5. ncbi Heparan sulphate and HB-GAM (heparin-binding growth-associated molecule) in the development of the thalamocortical pathway of rat brain
    A Kinnunen
    Institute of Biotechnology and the Department of Biosciences, University of Helsinki, Biocentre 2, Finland
    Eur J Neurosci 11:491-502. 1999
  6. ncbi Upregulation of HARP during in vitro myogenesis and rat soleus muscle regeneration
    Daniele Caruelle
    Laboratoire de Recherche sur la Croissance Cellulaire, la Réparation et la Régénération Tissulaires FRE CNRS 2412, Universite Paris Val de Marne, avenue du General de Gaulle, 94010 Creteil, France
    J Muscle Res Cell Motil 25:45-53. 2004
  7. ncbi Pleiotrophin stimulates fibroblasts and endothelial and epithelial cells and is expressed in human cancer
    W Fang
    V T Lombardi Cancer Center, Georgetown University, Washington, D C 20007
    J Biol Chem 267:25889-97. 1992
  8. doi Factors released from cholestatic rat livers possibly involved in inducing bone marrow hepatic stem cell priming
    Jun Xu
    Department of Medicine and Burns and Allen Research Institute, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    Stem Cells Dev 17:143-55. 2008
  9. doi Pleiotrophin inhibits transforming growth factor beta1-induced apoptosis in hepatoma cell lines
    Tae Jun Park
    Biochemistry and Molecular Biology, School of Medicine, Ajou University, Suwon, South Korea
    Mol Carcinog 47:784-96. 2008
  10. doi Heparin-binding determinants of GDNF reduce its tissue distribution but are beneficial for the protection of nigral dopaminergic neurons
    Marjo Piltonen
    Division of Pharmacology and Toxicology, Faculty of Pharmacy, P O Box 56, FIN 00014 University of Helsinki, Finland
    Exp Neurol 219:499-506. 2009

Scientific Experts

  • Irene R E Taravini
  • Satoshi Wakisaka
  • Keiko Nakanishi
  • S Besse
  • Daniel García-Pérez
  • Esther Gramage
  • Hideki Hida
  • Erkki Raulo
  • Marjo Piltonen
  • W Petersen
  • Deanna M Marchionini
  • H Rauvala
  • Gonzalo Herradon
  • Thomas F Deuel
  • Angelos Kaspiris
  • Laura Ezquerra
  • Philipp Ottis
  • Jiayin Miao
  • Mohamed Attia
  • Evangelia Papadimitriou
  • Hitomi Asai
  • Yang Yu
  • Nuria Del Olmo
  • Luis F Alguacil
  • Arlette Duchesnay
  • Peter Landgraf
  • Anastasia Parthymou
  • Jose Courty
  • Isabelle Martelly
  • Jun Xu
  • Tae Jun Park
  • Jinliang Li
  • Ruifa Mi
  • A Kinnunen
  • Jérôme Roger
  • Xingfeng Bao
  • M Antoine
  • Katsutoshi Yoshizato
  • Chise Tateno
  • Karen L Christman
  • T Kinnunen
  • Daniele Caruelle
  • S E Lauri
  • R Nolo
  • Lubna Khaldi
  • Margarita Lamprou
  • Efstathios Chronopoulos
  • Nikolaos Papaioannou
  • Ismene A Dontas
  • Elias Vasiliadis
  • Theodoros B Grivas
  • Pavlos P Lelovas
  • T Kohashi
  • Kinji Asahina
  • Daniela Schulz
  • Joseph P Huston
  • Angelica de Souza
  • Bianca Topic
  • Ka Wan Li
  • Carsten Korth
  • Maarten Loos
  • August B Smit
  • Camille Gossard
  • Toin H van Kuppevelt
  • Minghui Ding
  • Gilles Carpentier
  • Aiwu Zhang
  • Yannan Fang
  • Weiwei Qi
  • Ning Luo
  • Wei Di
  • Alexander Scott
  • Minh Bao Huynh
  • Zijian Xiao
  • Yuqian Tao
  • Marie Claude Tassoni
  • Louis J Soslowsky
  • Seiji Miyata
  • Shoko Morita
  • Jian fei Chen
  • Bin Cui
  • Shi Yong Yu
  • Ming Bao Song
  • Lan Huang
  • Yu Gao
  • Chun Yan Kuang
  • Jun Qin
  • Pablo Perez-Pinera
  • Hans Christian Pape
  • In Kyoung Lim

Detail Information

Publications58

  1. doi Neuroglycan C, a brain-specific chondroitin sulfate proteoglycan, interacts with pleiotrophin, a heparin-binding growth factor
    Keiko Nakanishi
    Department of Perinatology, Institute for Developmental Research, Aichi Human Service Center, Kasugai, Aichi, Japan
    Neurochem Res 35:1131-7. 2010
    ..Several proteins were eluted from the column including an 18 kDa-band protein recognized by an anti-pleiotrophin antibody...
  2. ncbi Basic FGF and FGF receptor 1 are expressed in microglia during experimental autoimmune encephalomyelitis: temporally distinct expression of midkine and pleiotrophin
    X Liu
    Laboratory of Experimental Neuropathology, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA
    Glia 24:390-7. 1998
    ..assess the expression pattern and possible function in multiple sclerosis, the heparin-binding growth factors pleiotrophin (PTN), midkine (MK), basic fibroblast growth factor (FGF-2) and one of its receptors (FGFR1/flg) mRNA and ..
  3. ncbi Upregulation of the angiogenic factor heparin affin regulatory peptide by progesterone in rat uterus
    P E Milhiet
    Laboratoire de Recherche sur la Croissance Cellulaire, la Réparation et la Régénération Tissulaires CRRET, CNRS UPRESA 7053, Universite Paris XII, Creteil, France
    J Endocrinol 158:389-99. 1998
    Heparin affin regulatory peptide (HARP), also named pleiotropin, is a secreted polypeptide that belongs to a new family of heparin-binding growth/differentiation factors...
  4. ncbi Immunohistochemical localization of pleiotrophin and midkine in the lingual epithelium of the adult rat
    S Wakisaka
    Department of Oral Anatomy and Developmental Biology, Osaka University Faculty of Dentistry, Japan
    Arch Histol Cytol 61:475-80. 1998
    Distribution of two heparin-binding molecules, pleiotrophin (PTN) and midkine (MK), was investigated by immunohistochemistry in the lingual epithelium of the adult rat...
  5. ncbi Heparan sulphate and HB-GAM (heparin-binding growth-associated molecule) in the development of the thalamocortical pathway of rat brain
    A Kinnunen
    Institute of Biotechnology and the Department of Biosciences, University of Helsinki, Biocentre 2, Finland
    Eur J Neurosci 11:491-502. 1999
    ..Our results suggest that HB-GAM is important for the neurite outgrowth of thalamic neurons and it may function as an ECM-bound guidance cue for thalamic neurons that possess HB-GAM-binding heparan sulphates on their cell membrane...
  6. ncbi Upregulation of HARP during in vitro myogenesis and rat soleus muscle regeneration
    Daniele Caruelle
    Laboratoire de Recherche sur la Croissance Cellulaire, la Réparation et la Régénération Tissulaires FRE CNRS 2412, Universite Paris Val de Marne, avenue du General de Gaulle, 94010 Creteil, France
    J Muscle Res Cell Motil 25:45-53. 2004
    Heparin affin regulatory peptide (HARP) is a heparin binding growth factor that belongs to a family of molecule whose biological function in myogenesis has been suspected without formal demonstration...
  7. ncbi Pleiotrophin stimulates fibroblasts and endothelial and epithelial cells and is expressed in human cancer
    W Fang
    V T Lombardi Cancer Center, Georgetown University, Washington, D C 20007
    J Biol Chem 267:25889-97. 1992
    Previously we reported the purification of the heparin-binding growth factor pleiotrophin (PTN) from supernatants of the human breast cancer cell line MDA-MB-231...
  8. doi Factors released from cholestatic rat livers possibly involved in inducing bone marrow hepatic stem cell priming
    Jun Xu
    Department of Medicine and Burns and Allen Research Institute, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    Stem Cells Dev 17:143-55. 2008
    ..analysis showed many up-regulated genes belonged to cytokines, chemokines and growth factors, including Il1b, Il18, Ptn, Spp1, Grn, Ccl2, Cxcl1, Pf4, Tgfb, and Tgfb3...
  9. doi Pleiotrophin inhibits transforming growth factor beta1-induced apoptosis in hepatoma cell lines
    Tae Jun Park
    Biochemistry and Molecular Biology, School of Medicine, Ajou University, Suwon, South Korea
    Mol Carcinog 47:784-96. 2008
    b>Pleiotrophin (PTN) is a hepatocyte growth factor and considered to play roles in liver fibrogenesis and hepatocarcinogenesis. In this study we examined the mechanism of the action of PTN in these pathological processes...
  10. doi Heparin-binding determinants of GDNF reduce its tissue distribution but are beneficial for the protection of nigral dopaminergic neurons
    Marjo Piltonen
    Division of Pharmacology and Toxicology, Faculty of Pharmacy, P O Box 56, FIN 00014 University of Helsinki, Finland
    Exp Neurol 219:499-506. 2009
    ..non-heparin-binding Delta38N-GDNF or combined wtGDNF with heparin-binding growth-associated molecule (HB-GAM, pleiotrophin). Tissue diffusion of wtGDNF+/-HB-GAM and Delta38N-GDNF was also compared...
  11. ncbi Heparin-binding growth factor, pleiotrophin, mediates neuritogenic activity of embryonic pig brain-derived chondroitin sulfate/dermatan sulfate hybrid chains
    Xingfeng Bao
    Department of Biochemistry, Kobe Pharmaceutical University, Higashinada ku, Kobe 658 8558, Japan
    J Biol Chem 280:9180-91. 2005
    ..However, the neuritogenic mechanism is not well understood. Here we showed that pleiotrophin (PTN), a heparin-binding growth factor, produced mainly by glia cells, was the predominant binding partner for ..
  12. doi Genetic deletion of pleiotrophin leads to disruption of spinal nociceptive transmission: evidence for pleiotrophin modulation of morphine-induced analgesia
    Esther Gramage
    Laboratory of Pharmacology and Toxicology, Universidad San Pablo CEU, Urb Monteprincipe, Madrid, Spain
    Eur J Pharmacol 647:97-102. 2010
    b>Pleiotrophin (PTN) is a growth factor that exhibits neurotrophic actions and is upregulated at sites of nerve injury...
  13. doi CCN1 promotes the differentiation of endothelial progenitor cells and reendothelialization in the early phase after vascular injury
    Yang Yu
    Institute of Cardiovascular Diseases, Xinqiao Hospital, Third Military Medical University, Chongqing, 400037, China
    Basic Res Cardiol 105:713-24. 2010
    ..expressed during CCN1-induced EPC differentiation, including Id1, Vegf-b, Vegf-c, Kdr, Igf-1, Ereg, Tgf, Mdk, Ptn, Timp2, etc...
  14. doi 1α,25-Dihydroxyvitamin D(3) down-regulates pleiotrophin messenger RNA expression in osteoblast-like cells
    M Tamura
    Department of Molecular Pharmacology, Division of Functional Disorder Research, Medical Research Institute, Tokyo Medical and Dental University, 101, Tokyo, Japan
    Endocrine 3:21-4. 1995
    b>Pleiotrophin (PTN)[heparin-binding-growth-associated molecule (HB-GAM), heparin-binding neurite-promoting factor (HBNF)] is a recently identified polypeptide that stimulates growth of fibroblasts and enhances neurite extension...
  15. ncbi Intramyocardial protein therapy with vascular endothelial growth factor (VEGF-165) induces functional angiogenesis in rat senescent myocardium
    S Besse
    Laboratoire Croissance cellulaire, Reparation et Regeneration Tissulaires, EAC CNRS 7149, Universite Paris Est, Creteil, France
    J Physiol Pharmacol 61:651-61. 2010
    ..VEGF/VEGF-R2, Ang-1/Ang-2/Tie-2 and PTN levels, quantitated in left ventricle by western blotting and immunohistochemistry, showed that VEGF and VEGF-R2 ..
  16. pmc Aging-induced proteostatic changes in the rat hippocampus identify ARP3, NEB2 and BRAG2 as a molecular circuitry for cognitive impairment
    Philipp Ottis
    Department of Neuropathology, Heinrich Heine University of Dusseldorf, Dusseldorf, Germany
    PLoS ONE 8:e75112. 2013
    ..reveal a previously unknown functional network of proteins (ARP3, NEB2, BRAG2) involved in age-associated cognitive dysfunction. ..
  17. doi Glial activation and midkine and pleiotrophin transcription in the ventral tegmental area are modulated by morphine administration
    Daniel García-Pérez
    Group of Molecular and Cellular Pharmacology, Medical Faculty of Murcia, Campus de Espinardo, 30100 Murcia, Spain Instituto Murciano de Investigación Biosanitaria IMIB, Murcia, Spain Electronic address
    J Neuroimmunol 274:244-8. 2014
    Opiates cause persistent restructuring in the mesolimbic reward system. Although a possible role for midkine and pleiotrophin cytokines in the field of synaptic plasticity has been proposed, it has not been assessed whether morphine ..
  18. doi Pleiotrophin modulates morphine withdrawal but has no effects on morphine-conditioned place preference
    Esther Gramage
    Pharmacology Lab, Department of Pharmaceutical and Health Sciences, Facultad de Farmacia, Universidad CEU San Pablo, Madrid, Spain Electronic address
    Neurosci Lett 604:75-9. 2015
    b>Pleiotrophin (PTN) is a neurotrophic factor with important functions in addiction and neurodegenerative disorders...
  19. doi Effects of mechanical loading on the expression of pleiotrophin and its receptor protein tyrosine phosphatase beta/zeta in a rat spinal deformity model
    Angelos Kaspiris
    Laboratory of Molecular Pharmacology, School of Health Sciences, University of Patras, Patras 26504, Greece Laboratory for Research of the Musculoskeletal System, School of Medicine, University of Athens, Athens 14561, Greece
    Cytokine 78:7-15. 2016
    ..b>Pleiotrophin (PTN) is a growth factor with a putative role in bone remodeling through its receptor protein tyrosine ..
  20. ncbi N-syndecan and HB-GAM (heparin-binding growth-associated molecule) associate with early axonal tracts in the rat brain
    A Kinnunen
    Institute of Biomedicine, Department of Anatomy, University of Helsinki, Finland
    Eur J Neurosci 10:635-48. 1998
    Heparin-Binding Growth-Associated Molecule (HB-GAM)/pleiotrophin is an 18 kDa extracellular matrix- and cell-surface-associated protein shown to enhance neurite outgrowth of perinatal forebrain neurones in vitro...
  21. ncbi Upregulation of pleiotrophin gene expression in developing microvasculature, macrophages, and astrocytes after acute ischemic brain injury
    H J Yeh
    Department of Medicine, Division of Growth Regulation, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    J Neurosci 18:3699-707. 1998
    b>Pleiotrophin (PTN) is a heparin-binding, 18 kDa secretory protein that functions to induce mitogenesis, angiogenesis, differentiation, and transformation in vitro...
  22. ncbi Activity-induced enhancement of HB-GAM expression in rat hippocampal slices
    S E Lauri
    Department of Biosciences, University of Helsinki, Finland
    Neuroreport 7:1670-4. 1996
    ..The results indicate that high frequency stimulation inducing LTP results in calcium-dependent enhancement in HB-GAM expression, and imply a role for this extracellular protein in the modulation of synaptic function in the hippocampus...
  23. ncbi Role of HB-GAM (heparin-binding growth-associated molecule) in proliferation arrest in cells of the developing rat limb and its expression in the differentiating neuromuscular system
    E Szabat
    Laboratory of Molecular Neurobiology, Institute of Biotechnology, University of Helsinki, Finland
    Dev Biol 178:77-89. 1996
    ..This finding is in agreement with a previous study that has suggested a role for HB-GAM in the differentiation of the neuromuscular junction in Xenopus muscle...
  24. ncbi Effect of heparin-binding growth-associated molecule (HB-GAM) on synaptic transmission and early LTP in rat hippocampal slices
    S E Lauri
    Department of Biosciences, University of Helsinki, Finland
    Eur J Neurosci 10:188-94. 1998
    ..These results suggest that HB-GAM is involved in the regulation of synaptic plasticity in hippocampus...
  25. ncbi Developmentally regulated expression of pleiotrophin, a novel heparin binding growth factor, in the nervous system of the rat
    A Wanaka
    Department of Pathology, Washington University School of Medicine, St Louis, MO 63110
    Brain Res Dev Brain Res 72:133-44. 1993
    b>Pleiotrophin (PTN) is a newly identified heparin-binding growth factor which is closely related to the retinoic acid-inducible MK protein...
  26. ncbi Neurite outgrowth in brain neurons induced by heparin-binding growth-associated molecule (HB-GAM) depends on the specific interaction of HB-GAM with heparan sulfate at the cell surface
    T Kinnunen
    Laboratory of Molecular Neurobiology, University of Helsinki, Finland
    J Biol Chem 271:2243-8. 1996
    ..We suggest that this property of N-syndecan heparan sulfate is essential for HB-GAM binding and induction of neurite outgrowth...
  27. ncbi Isolation of a neuronal cell surface receptor of heparin binding growth-associated molecule (HB-GAM). Identification as N-syndecan (syndecan-3)
    E Raulo
    Laboratory of Molecular Neurobiology, University of Helsinki, Finland
    J Biol Chem 269:12999-3004. 1994
    HB-GAM (heparin binding growth-associated molecule; pleiotrophin) is a secretory, extracellular matrix-associated protein that is strongly expressed in developing nervous tissues and belongs to a novel family of differentiation/growth ..
  28. ncbi 6B4 proteoglycan/phosphacan, an extracellular variant of receptor-like protein-tyrosine phosphatase zeta/RPTPbeta, binds pleiotrophin/heparin-binding growth-associated molecule (HB-GAM)
    N Maeda
    Division of Molecular Neurobiology, National Institute for Basic Biology, and the Department of Molecular Biomechanics, The Graduate University for Advanced Studies, Okazaki 444, Japan
    J Biol Chem 271:21446-52. 1996
    ..N-terminal amino acid sequencing identified the 18-kDa protein as pleiotrophin/heparin-binding growth-associated molecule (HB-GAM)...
  29. ncbi Immunocytochemical localization of the heparin-binding growth-associated molecule (HB-GAM) in the developing and adult rat cerebellar cortex
    K Wewetzer
    University of Heidelberg, Department of Anatomy and Cell Biology, Germany
    Brain Res 693:31-8. 1995
    ..Therefore, it will be important to investigate whether specific antibodies against HB-GAM are able to interfere with normal cerebellar development in vitro and in vivo...
  30. ncbi delta-9-Tetrahydrocannabinol regulates gene expression of the growth factor pleiotrophin in the forebrain
    P Mailleux
    Unité de Recherche sur le Cerveau, Faculte de Medecine, Universite Libre de Bruxelles, Brussels, Belgium
    Neurosci Lett 175:25-7. 1994
    ..p.) on gene expression of the growth factor pleiotrophin (PTN) in the adult rat forebrain...
  31. ncbi Expression of HB-GAM (heparin-binding growth-associated molecules) in the pathways of developing axonal processes in vivo and neurite outgrowth in vitro induced by HB-GAM
    H Rauvala
    Institute of Biotechnology, University of Helsinki, Finland
    Brain Res Dev Brain Res 79:157-76. 1994
    ..We suggest that in developing nervous tissues HB-GAM is deposited to an extracellular location in developing axon pathways and it interacts with heparin-like molecules of the neuron surface to promote formation of neural connections...
  32. ncbi Receptor binding of osteoblast-specific factor 1 (OSF-1/HB-GAM) to human osteosarcoma cells promotes cell attachment
    C Gieffers
    Fakultat fur Chemie, Biochemie II, Universitat Bielefeld, Germany
    Eur J Cell Biol 62:352-61. 1993
    ..Our results indicate that one biological function of OSF-1 is the promotion of osteoblast attachment to the extracellular bone matrix...
  33. ncbi Induction of heparin-binding growth-associated molecule expression in reactive astrocytes following hippocampal neuronal injury
    A Takeda
    Department of Neurology, Tohoku University School of Medicine, Sendai, Japan
    Neuroscience 68:57-64. 1995
    ..The data presented here suggest that heparin-binding growth-associated molecule, produced by the reactive astrocytes, may play important roles in the repair process after neuronal injury...
  34. ncbi The role of heparin-binding growth-associated molecule (HB-GAM) in the postsynaptic induction in cultured muscle cells
    H B Peng
    Department of Cell Biology and Anatomy, University of North Carolina, Chapel Hill 27599, USA
    J Neurosci 15:3027-38. 1995
    ..Heparin-binding growth-associated molecule (HB-GAM; also known as pleiotrophin, or p18) is a newly discovered HSPG-bound factor that is expressed at high levels in the developing CNS and PNS...
  35. doi Effect of pleiotrophin on glutamate-induced neurotoxicity in cultured hippocampal neurons
    Hitomi Asai
    Department of Applied Biology, Kyoto Institute of Technology, Sakyo ku, Japan
    Cell Biochem Funct 29:660-5. 2011
    b>Pleiotrophin (PTN) is a secreted heparin-binding cytokine that signals diverse functions, including lineage-specific differentiation of glial progenitor cells, axonal outgrowth and angiogenesis...
  36. doi Alterations of overused supraspinatus tendon: a possible role of glycosaminoglycans and HARP/pleiotrophin in early tendon pathology
    Mohamed Attia
    Laboratoire CRRET CNRS EAC 7149, Université Paris Est Créteil, Cedex, France
    J Orthop Res 30:61-71. 2012
    ..Protein levels of heparin affine regulatory peptide (HARP)/pleiotrophin, a cytokine known to regulate developmental chondrocyte formation, were enhanced ..
  37. doi Pleiotrophin promotes microglia proliferation and secretion of neurotrophic factors by activating extracellular signal-regulated kinase 1/2 pathway
    Jiayin Miao
    Department of Neurology, First Affiliated Hospital of Sun Yat sen University, The 2nd Zhongshan Road, Guangzhou 510080, China
    Neurosci Res 74:269-76. 2012
    b>Pleiotrophin (PTN) is an effective neuroprotective factor and its expression is strikingly increased in microglia after ischemia/reperfusion injury...
  38. ncbi Heparin-binding neurotrophic factor (HBNF) and MK, members of a new family of homologous, developmentally regulated proteins
    I Kovesdi
    Medical Research Division, American Cyanamid Company, Pearl River, NY 10965
    Biochem Biophys Res Commun 172:850-4. 1990
    A partial rat cDNA clone coding for a novel neurotrophic factor HBNF was isolated...
  39. ncbi Amino-terminal sequences of a novel heparin-binding protein from human, bovine, rat, and chick brain: high interspecies homology
    D Huber
    Biochemisches Institut, Universitat Zurich, Switzerland
    Neurochem Res 15:435-9. 1990
    ..vascular endothelial cells and its ability to strongly bind heparin it was termed heparin-binding brain mitogen (HBBM)...
  40. ncbi Cloning and expression of a developmentally regulated protein that induces mitogenic and neurite outgrowth activity
    Y S Li
    Department of Medicine, Jewish Hospital, Washington University Medical Center, St Louis, MO 63110
    Science 250:1690-4. 1990
    ..This protein, previously designated as heparin binding growth factor (HBGF)-8, is now renamed pleiotrophin (PTN) to reflect its diverse activities...
  41. doi Pleiotrophin inhibits hippocampal long-term potentiation: a role of pleiotrophin in learning and memory
    Nuria Del Olmo
    Laboratory of Pharmacology and Toxicology, Universidad San Pablo CEU, Madrid, Spain
    Growth Factors 27:189-94. 2009
    b>Pleiotrophin (PTN) is a growth factor that has been shown to be involved in hippocampal synaptic plasticity and learning...
  42. ncbi Molecular cloning of the 18-kDa growth-associated protein of developing brain
    J Merenmies
    Department of Medical Chemistry, University of Helsinki, Finland
    J Biol Chem 265:16721-4. 1990
    ....
  43. doi Pleiotrophin prevents cocaine-induced toxicity in vitro
    Esther Gramage
    Lab Pharmacology and Toxicology, Univ CEU San Pablo, Madrid, Spain
    Eur J Pharmacol 595:35-8. 2008
    b>Pleiotrophin is a cytokine involved in differentiation, survival and repair processes in the central nervous system...
  44. pmc The survival-promoting peptide Y-P30 enhances binding of pleiotrophin to syndecan-2 and -3 and supports its neuritogenic activity
    Peter Landgraf
    Project Group Neuroplasticity, Leibniz Institute for Neurobiology, Brenneckestrasse 6, Magdeburg 39118, Germany
    J Biol Chem 283:25036-45. 2008
    ..In this study, we identify pleiotrophin (PTN) and syndecan-2 and -3 as direct binding partners of Y-P30...
  45. doi Different pattern of pleiotrophin and midkine expression in neuropathic pain: correlation between changes in pleiotrophin gene expression and rat strain differences in neuropathic pain
    Laura Ezquerra
    Department of Molecular and Experimental Medicine and Cell Biology, The Scripps Research Institute, La Jolla, CA, USA
    Growth Factors 26:44-8. 2008
    b>Pleiotrophin (PTN) and midkine (MK) are two growth factors highly redundant in function that exhibit neurotrophic actions and are upregulated at sites of nerve injury, both properties being compatible with a potential involvement in the ..
  46. ncbi The pro-angiogenic cytokine pleiotrophin potentiates cardiomyocyte apoptosis through inhibition of endogenous AKT/PKB activity
    Jinliang Li
    Laboratory of Cardiovascular Science, National Institute on Aging, Baltimore, Maryland 21224, USA
    J Biol Chem 282:34984-93. 2007
    b>Pleiotrophin is a development-regulated cytokine and growth factor that can promote angiogenesis, cell proliferation, or differentiation, and it has been reported to have neovasculogenic effects in damaged heart...
  47. ncbi Heparin affin regulatory peptide/pleiotrophin negatively affects diverse biological activities in C6 glioma cells
    Anastasia Parthymou
    Laboratory of Molecular Pharmacology, Department of Pharmacy, University of Patras, GR 26504 Patras, Greece
    Eur J Cell Biol 87:17-29. 2008
    Heparin affin regulatory peptide (HARP) or pleiotrophin seems to be involved in the progression of several tumors of diverse origin...
  48. ncbi Role of heparin binding growth factors in nigrostriatal dopamine system development and Parkinson's disease
    Deanna M Marchionini
    Dept Neurological Sciences, Rush University Medical Center, Chicago, IL 60612, USA
    Brain Res 1147:77-88. 2007
    ..Midkine, pleiotrophin (PTN), and their receptors syndecan-3 and receptor protein tyrosine phosphatase beta/zeta, were highly ..
  49. pmc Pleiotrophin is a neurotrophic factor for spinal motor neurons
    Ruifa Mi
    Departments of Neurology and Neuroscience, Johns Hopkins University School of Medicine, 600 North Wolfe Street, Baltimore, MD 21287, USA
    Proc Natl Acad Sci U S A 104:4664-9. 2007
    ..We discovered that the mRNA for pleiotrophin (PTN) was highly up-regulated in acutely denervated distal sciatic nerves, but high levels of PTN mRNA were not ..
  50. ncbi Involvement of Pleiotrophin in CNTF-mediated differentiation of the late retinal progenitor cells
    Jérôme Roger
    Laboratoire de Physiopathologie Cellulaire et Moleculaire de la Retine, UMR S 592 INSERM, Universite Pierre et Marie Curie PARIS6, Hopital Saint Antoine, Paris, France
    Dev Biol 298:527-39. 2006
    ..By this approach, we identified the Pleiotrophin (Ptn) as an upregulated gene in postnatal day 0 (P0) retinal explants upon addition of CNTF...
  51. ncbi Immunodetection of heparin-binding growth associated molecule (pleiotrophin) in striatal interneurons
    Irene R E Taravini
    Laboratorio de Parkinson Experimental, Instituto de Investigaciones Farmacologicas, CONICET, Junin 956, 5 piso, C1113AAD Buenos Aires, Argentina
    Brain Res 1066:196-200. 2005
    b>Pleiotrophin (PTN), a developmentally-regulated trophic factor, is over-expressed in the striatum of parkinsonian rats...
  52. ncbi Upregulation of pleiotrophin expression in rat hepatic stellate cells by PDGF and hypoxia: implications for its role in experimental biliary liver fibrogenesis
    M Antoine
    Institute of Clinical Chemistry and Pathobiochemistry, RWTH Aachen, Germany
    Biochem Biophys Res Commun 337:1153-64. 2005
    b>Pleiotrophin (PTN) is a secretory heparin binding protein with various biological activities including mitogenesis, angiogenesis, and tissue repair after injury...
  53. ncbi The two thrombospondin type I repeat domains of the heparin-binding growth-associated molecule bind to heparin/heparan sulfate and regulate neurite extension and plasticity in hippocampal neurons
    Erkki Raulo
    Neuroscience Center, University of Helsinki, Helsinki FIN 00014, Finland
    J Biol Chem 280:41576-83. 2005
    HB-GAM (heparin-binding growth-associated molecule, also designated as pleiotrophin) and midkine form a two-member family of extracellular matrix proteins that bind tightly to sulfated carbohydrate structures such as heparan sulfate...
  54. ncbi Pleiotrophin induces formation of functional neovasculature in vivo
    Karen L Christman
    University of California Berkeley and San Francisco Joint Bioengineering Graduate Group, USA
    Biochem Biophys Res Commun 332:1146-52. 2005
    b>Pleiotrophin (PTN) is a heparin-binding growth/differentiation inducing cytokine that shares 50% amino acid sequence identity and striking domain homology with Midkine (MK), the only other member of the Ptn/Mk developmental gene family...
  55. ncbi The angiogenic peptide pleiotrophin (PTN/HB-GAM) is expressed in fracture healing: an immunohistochemical study in rats
    Wolf Petersen
    Department of Trauma, Hand and Reconstructive Surgery, University Hospital Munster, Germany
    Arch Orthop Trauma Surg 124:603-7. 2004
    ..Formation of new blood vessels is essential for the process of fracture healing...
  56. ncbi Pleiotrophin exhibits a trophic effect on survival of dopaminergic neurons in vitro
    Hideki Hida
    Department of Neurophysiology and Brain Science, Nagoya City University Graduate School of Medical Sciences, Kawasumi 1, Mizuho ku, Nagoya 467 8601, Japan
    Eur J Neurosci 17:2127-34. 2003
    ..The microarray analysis revealed that pleiotrophin (PTN), glial-derived neurotopic factor (GDNF) and others were up-regulated in DA-depleted striatum...
  57. pmc Pleiotrophin/heparin-binding growth-associated molecule as a mitogen of rat hepatocytes and its role in regeneration and development of liver
    Kinji Asahina
    Hiroshima Tissue Regeneration Project, Hiroshima Prefecture Collaboration of Regional Entities for the Advancement of Technological Excellence, Japan Science and Technology Corporation, Hiroshima Prefectural Institute of Industrial Science and Technology
    Am J Pathol 160:2191-205. 2002
    Previously pleiotrophin (PTN) was identified among proteins secreted by Swiss 3T3 cells as a mitogen for cultured adult rat hepatocytes...
  58. ncbi Expression of pleiotrophin in hepatic nonparenchymal cells and preneoplastic nodules in carbon tetrachloride-induced fibrotic rat liver
    T Kohashi
    Department of Biological Science, Graduate School of Science, Hiroshima University, Higashihiroshima, Japan
    Growth Factors 20:53-60. 2002
    b>Pleiotrophin (PTN) is a heparin-binding protein, which induces growth, angiogenesis, differentiation, and transformation of cells. The aim of this study was to examine the role of PTN in liver fibrogenesis...