Genomes and Genes
Gene Symbol: Ptn
Alias: HARP, Hbnf, pleiotrophin, HB-GAM, HBBM, HBGF-8, OSF-1, Pleiotrophin (Heparine binding factor, Hbnf, in the mouse), heparin affine regulatory peptide, heparin binding factor, heparin-binding brain mitogen, heparin-binding growth factor 8, heparin-binding growth-associated molecule, heparin-binding neurotrophic factor, heparin-binding neutrophic factor, osteoblast-specific factor 1
- Neuroglycan C, a brain-specific chondroitin sulfate proteoglycan, interacts with pleiotrophin, a heparin-binding growth factorKeiko Nakanishi
Department of Perinatology, Institute for Developmental Research, Aichi Human Service Center, Kasugai, Aichi, Japan
Neurochem Res 35:1131-7. 2010..Several proteins were eluted from the column including an 18 kDa-band protein recognized by an anti-pleiotrophin antibody...
- Basic FGF and FGF receptor 1 are expressed in microglia during experimental autoimmune encephalomyelitis: temporally distinct expression of midkine and pleiotrophinX Liu
Laboratory of Experimental Neuropathology, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA
Glia 24:390-7. 1998..assess the expression pattern and possible function in multiple sclerosis, the heparin-binding growth factors pleiotrophin (PTN), midkine (MK), basic fibroblast growth factor (FGF-2) and one of its receptors (FGFR1/flg) mRNA and ..
- Upregulation of the angiogenic factor heparin affin regulatory peptide by progesterone in rat uterusP E Milhiet
Laboratoire de Recherche sur la Croissance Cellulaire, la Réparation et la Régénération Tissulaires CRRET, CNRS UPRESA 7053, Universite Paris XII, Creteil, France
J Endocrinol 158:389-99. 1998Heparin affin regulatory peptide (HARP), also named pleiotropin, is a secreted polypeptide that belongs to a new family of heparin-binding growth/differentiation factors...
- Immunohistochemical localization of pleiotrophin and midkine in the lingual epithelium of the adult ratS Wakisaka
Department of Oral Anatomy and Developmental Biology, Osaka University Faculty of Dentistry, Japan
Arch Histol Cytol 61:475-80. 1998Distribution of two heparin-binding molecules, pleiotrophin (PTN) and midkine (MK), was investigated by immunohistochemistry in the lingual epithelium of the adult rat...
- Heparan sulphate and HB-GAM (heparin-binding growth-associated molecule) in the development of the thalamocortical pathway of rat brainA Kinnunen
Institute of Biotechnology and the Department of Biosciences, University of Helsinki, Biocentre 2, Finland
Eur J Neurosci 11:491-502. 1999..Our results suggest that HB-GAM is important for the neurite outgrowth of thalamic neurons and it may function as an ECM-bound guidance cue for thalamic neurons that possess HB-GAM-binding heparan sulphates on their cell membrane...
- Upregulation of HARP during in vitro myogenesis and rat soleus muscle regenerationDaniele Caruelle
Laboratoire de Recherche sur la Croissance Cellulaire, la Réparation et la Régénération Tissulaires FRE CNRS 2412, Universite Paris Val de Marne, avenue du General de Gaulle, 94010 Creteil, France
J Muscle Res Cell Motil 25:45-53. 2004Heparin affin regulatory peptide (HARP) is a heparin binding growth factor that belongs to a family of molecule whose biological function in myogenesis has been suspected without formal demonstration...
- Pleiotrophin stimulates fibroblasts and endothelial and epithelial cells and is expressed in human cancerW Fang
V T Lombardi Cancer Center, Georgetown University, Washington, D C 20007
J Biol Chem 267:25889-97. 1992Previously we reported the purification of the heparin-binding growth factor pleiotrophin (PTN) from supernatants of the human breast cancer cell line MDA-MB-231...
- Factors released from cholestatic rat livers possibly involved in inducing bone marrow hepatic stem cell primingJun Xu
Department of Medicine and Burns and Allen Research Institute, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
Stem Cells Dev 17:143-55. 2008..analysis showed many up-regulated genes belonged to cytokines, chemokines and growth factors, including Il1b, Il18, Ptn, Spp1, Grn, Ccl2, Cxcl1, Pf4, Tgfb, and Tgfb3...
- Pleiotrophin inhibits transforming growth factor beta1-induced apoptosis in hepatoma cell linesTae Jun Park
Biochemistry and Molecular Biology, School of Medicine, Ajou University, Suwon, South Korea
Mol Carcinog 47:784-96. 2008b>Pleiotrophin (PTN) is a hepatocyte growth factor and considered to play roles in liver fibrogenesis and hepatocarcinogenesis. In this study we examined the mechanism of the action of PTN in these pathological processes...
- Heparin-binding determinants of GDNF reduce its tissue distribution but are beneficial for the protection of nigral dopaminergic neuronsMarjo Piltonen
Division of Pharmacology and Toxicology, Faculty of Pharmacy, P O Box 56, FIN 00014 University of Helsinki, Finland
Exp Neurol 219:499-506. 2009..non-heparin-binding Delta38N-GDNF or combined wtGDNF with heparin-binding growth-associated molecule (HB-GAM, pleiotrophin). Tissue diffusion of wtGDNF+/-HB-GAM and Delta38N-GDNF was also compared...
- Heparin-binding growth factor, pleiotrophin, mediates neuritogenic activity of embryonic pig brain-derived chondroitin sulfate/dermatan sulfate hybrid chainsXingfeng Bao
Department of Biochemistry, Kobe Pharmaceutical University, Higashinada ku, Kobe 658 8558, Japan
J Biol Chem 280:9180-91. 2005..However, the neuritogenic mechanism is not well understood. Here we showed that pleiotrophin (PTN), a heparin-binding growth factor, produced mainly by glia cells, was the predominant binding partner for ..
- Genetic deletion of pleiotrophin leads to disruption of spinal nociceptive transmission: evidence for pleiotrophin modulation of morphine-induced analgesiaEsther Gramage
Laboratory of Pharmacology and Toxicology, Universidad San Pablo CEU, Urb Monteprincipe, Madrid, Spain
Eur J Pharmacol 647:97-102. 2010b>Pleiotrophin (PTN) is a growth factor that exhibits neurotrophic actions and is upregulated at sites of nerve injury...
- CCN1 promotes the differentiation of endothelial progenitor cells and reendothelialization in the early phase after vascular injuryYang Yu
Institute of Cardiovascular Diseases, Xinqiao Hospital, Third Military Medical University, Chongqing, 400037, China
Basic Res Cardiol 105:713-24. 2010..expressed during CCN1-induced EPC differentiation, including Id1, Vegf-b, Vegf-c, Kdr, Igf-1, Ereg, Tgf, Mdk, Ptn, Timp2, etc...
- 1α,25-Dihydroxyvitamin D(3) down-regulates pleiotrophin messenger RNA expression in osteoblast-like cellsM Tamura
Department of Molecular Pharmacology, Division of Functional Disorder Research, Medical Research Institute, Tokyo Medical and Dental University, 101, Tokyo, Japan
Endocrine 3:21-4. 1995b>Pleiotrophin (PTN)[heparin-binding-growth-associated molecule (HB-GAM), heparin-binding neurite-promoting factor (HBNF)] is a recently identified polypeptide that stimulates growth of fibroblasts and enhances neurite extension...
- Intramyocardial protein therapy with vascular endothelial growth factor (VEGF-165) induces functional angiogenesis in rat senescent myocardiumS Besse
Laboratoire Croissance cellulaire, Reparation et Regeneration Tissulaires, EAC CNRS 7149, Universite Paris Est, Creteil, France
J Physiol Pharmacol 61:651-61. 2010..VEGF/VEGF-R2, Ang-1/Ang-2/Tie-2 and PTN levels, quantitated in left ventricle by western blotting and immunohistochemistry, showed that VEGF and VEGF-R2 ..
- Aging-induced proteostatic changes in the rat hippocampus identify ARP3, NEB2 and BRAG2 as a molecular circuitry for cognitive impairmentPhilipp Ottis
Department of Neuropathology, Heinrich Heine University of Dusseldorf, Dusseldorf, Germany
PLoS ONE 8:e75112. 2013..reveal a previously unknown functional network of proteins (ARP3, NEB2, BRAG2) involved in age-associated cognitive dysfunction. ..
- Glial activation and midkine and pleiotrophin transcription in the ventral tegmental area are modulated by morphine administrationDaniel García-Pérez
Group of Molecular and Cellular Pharmacology, Medical Faculty of Murcia, Campus de Espinardo, 30100 Murcia, Spain Instituto Murciano de Investigación Biosanitaria IMIB, Murcia, Spain Electronic address
J Neuroimmunol 274:244-8. 2014Opiates cause persistent restructuring in the mesolimbic reward system. Although a possible role for midkine and pleiotrophin cytokines in the field of synaptic plasticity has been proposed, it has not been assessed whether morphine ..
- Pleiotrophin modulates morphine withdrawal but has no effects on morphine-conditioned place preferenceEsther Gramage
Pharmacology Lab, Department of Pharmaceutical and Health Sciences, Facultad de Farmacia, Universidad CEU San Pablo, Madrid, Spain Electronic address
Neurosci Lett 604:75-9. 2015b>Pleiotrophin (PTN) is a neurotrophic factor with important functions in addiction and neurodegenerative disorders...
- Effects of mechanical loading on the expression of pleiotrophin and its receptor protein tyrosine phosphatase beta/zeta in a rat spinal deformity modelAngelos Kaspiris
Laboratory of Molecular Pharmacology, School of Health Sciences, University of Patras, Patras 26504, Greece Laboratory for Research of the Musculoskeletal System, School of Medicine, University of Athens, Athens 14561, Greece
Cytokine 78:7-15. 2016..b>Pleiotrophin (PTN) is a growth factor with a putative role in bone remodeling through its receptor protein tyrosine ..
- N-syndecan and HB-GAM (heparin-binding growth-associated molecule) associate with early axonal tracts in the rat brainA Kinnunen
Institute of Biomedicine, Department of Anatomy, University of Helsinki, Finland
Eur J Neurosci 10:635-48. 1998Heparin-Binding Growth-Associated Molecule (HB-GAM)/pleiotrophin is an 18 kDa extracellular matrix- and cell-surface-associated protein shown to enhance neurite outgrowth of perinatal forebrain neurones in vitro...
- Upregulation of pleiotrophin gene expression in developing microvasculature, macrophages, and astrocytes after acute ischemic brain injuryH J Yeh
Department of Medicine, Division of Growth Regulation, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
J Neurosci 18:3699-707. 1998b>Pleiotrophin (PTN) is a heparin-binding, 18 kDa secretory protein that functions to induce mitogenesis, angiogenesis, differentiation, and transformation in vitro...
- Activity-induced enhancement of HB-GAM expression in rat hippocampal slicesS E Lauri
Department of Biosciences, University of Helsinki, Finland
Neuroreport 7:1670-4. 1996..The results indicate that high frequency stimulation inducing LTP results in calcium-dependent enhancement in HB-GAM expression, and imply a role for this extracellular protein in the modulation of synaptic function in the hippocampus...
- Role of HB-GAM (heparin-binding growth-associated molecule) in proliferation arrest in cells of the developing rat limb and its expression in the differentiating neuromuscular systemE Szabat
Laboratory of Molecular Neurobiology, Institute of Biotechnology, University of Helsinki, Finland
Dev Biol 178:77-89. 1996..This finding is in agreement with a previous study that has suggested a role for HB-GAM in the differentiation of the neuromuscular junction in Xenopus muscle...
- Effect of heparin-binding growth-associated molecule (HB-GAM) on synaptic transmission and early LTP in rat hippocampal slicesS E Lauri
Department of Biosciences, University of Helsinki, Finland
Eur J Neurosci 10:188-94. 1998..These results suggest that HB-GAM is involved in the regulation of synaptic plasticity in hippocampus...
- Developmentally regulated expression of pleiotrophin, a novel heparin binding growth factor, in the nervous system of the ratA Wanaka
Department of Pathology, Washington University School of Medicine, St Louis, MO 63110
Brain Res Dev Brain Res 72:133-44. 1993b>Pleiotrophin (PTN) is a newly identified heparin-binding growth factor which is closely related to the retinoic acid-inducible MK protein...
- Neurite outgrowth in brain neurons induced by heparin-binding growth-associated molecule (HB-GAM) depends on the specific interaction of HB-GAM with heparan sulfate at the cell surfaceT Kinnunen
Laboratory of Molecular Neurobiology, University of Helsinki, Finland
J Biol Chem 271:2243-8. 1996..We suggest that this property of N-syndecan heparan sulfate is essential for HB-GAM binding and induction of neurite outgrowth...
- Isolation of a neuronal cell surface receptor of heparin binding growth-associated molecule (HB-GAM). Identification as N-syndecan (syndecan-3)E Raulo
Laboratory of Molecular Neurobiology, University of Helsinki, Finland
J Biol Chem 269:12999-3004. 1994HB-GAM (heparin binding growth-associated molecule; pleiotrophin) is a secretory, extracellular matrix-associated protein that is strongly expressed in developing nervous tissues and belongs to a novel family of differentiation/growth ..
- 6B4 proteoglycan/phosphacan, an extracellular variant of receptor-like protein-tyrosine phosphatase zeta/RPTPbeta, binds pleiotrophin/heparin-binding growth-associated molecule (HB-GAM)N Maeda
Division of Molecular Neurobiology, National Institute for Basic Biology, and the Department of Molecular Biomechanics, The Graduate University for Advanced Studies, Okazaki 444, Japan
J Biol Chem 271:21446-52. 1996..N-terminal amino acid sequencing identified the 18-kDa protein as pleiotrophin/heparin-binding growth-associated molecule (HB-GAM)...
- Immunocytochemical localization of the heparin-binding growth-associated molecule (HB-GAM) in the developing and adult rat cerebellar cortexK Wewetzer
University of Heidelberg, Department of Anatomy and Cell Biology, Germany
Brain Res 693:31-8. 1995..Therefore, it will be important to investigate whether specific antibodies against HB-GAM are able to interfere with normal cerebellar development in vitro and in vivo...
- delta-9-Tetrahydrocannabinol regulates gene expression of the growth factor pleiotrophin in the forebrainP Mailleux
Unité de Recherche sur le Cerveau, Faculte de Medecine, Universite Libre de Bruxelles, Brussels, Belgium
Neurosci Lett 175:25-7. 1994..p.) on gene expression of the growth factor pleiotrophin (PTN) in the adult rat forebrain...
- Expression of HB-GAM (heparin-binding growth-associated molecules) in the pathways of developing axonal processes in vivo and neurite outgrowth in vitro induced by HB-GAMH Rauvala
Institute of Biotechnology, University of Helsinki, Finland
Brain Res Dev Brain Res 79:157-76. 1994..We suggest that in developing nervous tissues HB-GAM is deposited to an extracellular location in developing axon pathways and it interacts with heparin-like molecules of the neuron surface to promote formation of neural connections...
- Receptor binding of osteoblast-specific factor 1 (OSF-1/HB-GAM) to human osteosarcoma cells promotes cell attachmentC Gieffers
Fakultat fur Chemie, Biochemie II, Universitat Bielefeld, Germany
Eur J Cell Biol 62:352-61. 1993..Our results indicate that one biological function of OSF-1 is the promotion of osteoblast attachment to the extracellular bone matrix...
- Induction of heparin-binding growth-associated molecule expression in reactive astrocytes following hippocampal neuronal injuryA Takeda
Department of Neurology, Tohoku University School of Medicine, Sendai, Japan
Neuroscience 68:57-64. 1995..The data presented here suggest that heparin-binding growth-associated molecule, produced by the reactive astrocytes, may play important roles in the repair process after neuronal injury...
- The role of heparin-binding growth-associated molecule (HB-GAM) in the postsynaptic induction in cultured muscle cellsH B Peng
Department of Cell Biology and Anatomy, University of North Carolina, Chapel Hill 27599, USA
J Neurosci 15:3027-38. 1995..Heparin-binding growth-associated molecule (HB-GAM; also known as pleiotrophin, or p18) is a newly discovered HSPG-bound factor that is expressed at high levels in the developing CNS and PNS...
- Effect of pleiotrophin on glutamate-induced neurotoxicity in cultured hippocampal neuronsHitomi Asai
Department of Applied Biology, Kyoto Institute of Technology, Sakyo ku, Japan
Cell Biochem Funct 29:660-5. 2011b>Pleiotrophin (PTN) is a secreted heparin-binding cytokine that signals diverse functions, including lineage-specific differentiation of glial progenitor cells, axonal outgrowth and angiogenesis...
- Alterations of overused supraspinatus tendon: a possible role of glycosaminoglycans and HARP/pleiotrophin in early tendon pathologyMohamed Attia
Laboratoire CRRET CNRS EAC 7149, Université Paris Est Créteil, Cedex, France
J Orthop Res 30:61-71. 2012..Protein levels of heparin affine regulatory peptide (HARP)/pleiotrophin, a cytokine known to regulate developmental chondrocyte formation, were enhanced ..
- Pleiotrophin promotes microglia proliferation and secretion of neurotrophic factors by activating extracellular signal-regulated kinase 1/2 pathwayJiayin Miao
Department of Neurology, First Affiliated Hospital of Sun Yat sen University, The 2nd Zhongshan Road, Guangzhou 510080, China
Neurosci Res 74:269-76. 2012b>Pleiotrophin (PTN) is an effective neuroprotective factor and its expression is strikingly increased in microglia after ischemia/reperfusion injury...
- Heparin-binding neurotrophic factor (HBNF) and MK, members of a new family of homologous, developmentally regulated proteinsI Kovesdi
Medical Research Division, American Cyanamid Company, Pearl River, NY 10965
Biochem Biophys Res Commun 172:850-4. 1990A partial rat cDNA clone coding for a novel neurotrophic factor HBNF was isolated...
- Amino-terminal sequences of a novel heparin-binding protein from human, bovine, rat, and chick brain: high interspecies homologyD Huber
Biochemisches Institut, Universitat Zurich, Switzerland
Neurochem Res 15:435-9. 1990..vascular endothelial cells and its ability to strongly bind heparin it was termed heparin-binding brain mitogen (HBBM)...
- Cloning and expression of a developmentally regulated protein that induces mitogenic and neurite outgrowth activityY S Li
Department of Medicine, Jewish Hospital, Washington University Medical Center, St Louis, MO 63110
Science 250:1690-4. 1990..This protein, previously designated as heparin binding growth factor (HBGF)-8, is now renamed pleiotrophin (PTN) to reflect its diverse activities...
- Pleiotrophin inhibits hippocampal long-term potentiation: a role of pleiotrophin in learning and memoryNuria Del Olmo
Laboratory of Pharmacology and Toxicology, Universidad San Pablo CEU, Madrid, Spain
Growth Factors 27:189-94. 2009b>Pleiotrophin (PTN) is a growth factor that has been shown to be involved in hippocampal synaptic plasticity and learning...
- Molecular cloning of the 18-kDa growth-associated protein of developing brainJ Merenmies
Department of Medical Chemistry, University of Helsinki, Finland
J Biol Chem 265:16721-4. 1990....
- Pleiotrophin prevents cocaine-induced toxicity in vitroEsther Gramage
Lab Pharmacology and Toxicology, Univ CEU San Pablo, Madrid, Spain
Eur J Pharmacol 595:35-8. 2008b>Pleiotrophin is a cytokine involved in differentiation, survival and repair processes in the central nervous system...
- The survival-promoting peptide Y-P30 enhances binding of pleiotrophin to syndecan-2 and -3 and supports its neuritogenic activityPeter Landgraf
Project Group Neuroplasticity, Leibniz Institute for Neurobiology, Brenneckestrasse 6, Magdeburg 39118, Germany
J Biol Chem 283:25036-45. 2008..In this study, we identify pleiotrophin (PTN) and syndecan-2 and -3 as direct binding partners of Y-P30...
- Different pattern of pleiotrophin and midkine expression in neuropathic pain: correlation between changes in pleiotrophin gene expression and rat strain differences in neuropathic painLaura Ezquerra
Department of Molecular and Experimental Medicine and Cell Biology, The Scripps Research Institute, La Jolla, CA, USA
Growth Factors 26:44-8. 2008b>Pleiotrophin (PTN) and midkine (MK) are two growth factors highly redundant in function that exhibit neurotrophic actions and are upregulated at sites of nerve injury, both properties being compatible with a potential involvement in the ..
- The pro-angiogenic cytokine pleiotrophin potentiates cardiomyocyte apoptosis through inhibition of endogenous AKT/PKB activityJinliang Li
Laboratory of Cardiovascular Science, National Institute on Aging, Baltimore, Maryland 21224, USA
J Biol Chem 282:34984-93. 2007b>Pleiotrophin is a development-regulated cytokine and growth factor that can promote angiogenesis, cell proliferation, or differentiation, and it has been reported to have neovasculogenic effects in damaged heart...
- Heparin affin regulatory peptide/pleiotrophin negatively affects diverse biological activities in C6 glioma cellsAnastasia Parthymou
Laboratory of Molecular Pharmacology, Department of Pharmacy, University of Patras, GR 26504 Patras, Greece
Eur J Cell Biol 87:17-29. 2008Heparin affin regulatory peptide (HARP) or pleiotrophin seems to be involved in the progression of several tumors of diverse origin...
- Role of heparin binding growth factors in nigrostriatal dopamine system development and Parkinson's diseaseDeanna M Marchionini
Dept Neurological Sciences, Rush University Medical Center, Chicago, IL 60612, USA
Brain Res 1147:77-88. 2007..Midkine, pleiotrophin (PTN), and their receptors syndecan-3 and receptor protein tyrosine phosphatase beta/zeta, were highly ..
- Pleiotrophin is a neurotrophic factor for spinal motor neuronsRuifa Mi
Departments of Neurology and Neuroscience, Johns Hopkins University School of Medicine, 600 North Wolfe Street, Baltimore, MD 21287, USA
Proc Natl Acad Sci U S A 104:4664-9. 2007..We discovered that the mRNA for pleiotrophin (PTN) was highly up-regulated in acutely denervated distal sciatic nerves, but high levels of PTN mRNA were not ..
- Involvement of Pleiotrophin in CNTF-mediated differentiation of the late retinal progenitor cellsJérôme Roger
Laboratoire de Physiopathologie Cellulaire et Moleculaire de la Retine, UMR S 592 INSERM, Universite Pierre et Marie Curie PARIS6, Hopital Saint Antoine, Paris, France
Dev Biol 298:527-39. 2006..By this approach, we identified the Pleiotrophin (Ptn) as an upregulated gene in postnatal day 0 (P0) retinal explants upon addition of CNTF...
- Immunodetection of heparin-binding growth associated molecule (pleiotrophin) in striatal interneuronsIrene R E Taravini
Laboratorio de Parkinson Experimental, Instituto de Investigaciones Farmacologicas, CONICET, Junin 956, 5 piso, C1113AAD Buenos Aires, Argentina
Brain Res 1066:196-200. 2005b>Pleiotrophin (PTN), a developmentally-regulated trophic factor, is over-expressed in the striatum of parkinsonian rats...
- Upregulation of pleiotrophin expression in rat hepatic stellate cells by PDGF and hypoxia: implications for its role in experimental biliary liver fibrogenesisM Antoine
Institute of Clinical Chemistry and Pathobiochemistry, RWTH Aachen, Germany
Biochem Biophys Res Commun 337:1153-64. 2005b>Pleiotrophin (PTN) is a secretory heparin binding protein with various biological activities including mitogenesis, angiogenesis, and tissue repair after injury...
- The two thrombospondin type I repeat domains of the heparin-binding growth-associated molecule bind to heparin/heparan sulfate and regulate neurite extension and plasticity in hippocampal neuronsErkki Raulo
Neuroscience Center, University of Helsinki, Helsinki FIN 00014, Finland
J Biol Chem 280:41576-83. 2005HB-GAM (heparin-binding growth-associated molecule, also designated as pleiotrophin) and midkine form a two-member family of extracellular matrix proteins that bind tightly to sulfated carbohydrate structures such as heparan sulfate...
- Pleiotrophin induces formation of functional neovasculature in vivoKaren L Christman
University of California Berkeley and San Francisco Joint Bioengineering Graduate Group, USA
Biochem Biophys Res Commun 332:1146-52. 2005b>Pleiotrophin (PTN) is a heparin-binding growth/differentiation inducing cytokine that shares 50% amino acid sequence identity and striking domain homology with Midkine (MK), the only other member of the Ptn/Mk developmental gene family...
- The angiogenic peptide pleiotrophin (PTN/HB-GAM) is expressed in fracture healing: an immunohistochemical study in ratsWolf Petersen
Department of Trauma, Hand and Reconstructive Surgery, University Hospital Munster, Germany
Arch Orthop Trauma Surg 124:603-7. 2004..Formation of new blood vessels is essential for the process of fracture healing...
- Pleiotrophin exhibits a trophic effect on survival of dopaminergic neurons in vitroHideki Hida
Department of Neurophysiology and Brain Science, Nagoya City University Graduate School of Medical Sciences, Kawasumi 1, Mizuho ku, Nagoya 467 8601, Japan
Eur J Neurosci 17:2127-34. 2003..The microarray analysis revealed that pleiotrophin (PTN), glial-derived neurotopic factor (GDNF) and others were up-regulated in DA-depleted striatum...
- Pleiotrophin/heparin-binding growth-associated molecule as a mitogen of rat hepatocytes and its role in regeneration and development of liverKinji Asahina
Hiroshima Tissue Regeneration Project, Hiroshima Prefecture Collaboration of Regional Entities for the Advancement of Technological Excellence, Japan Science and Technology Corporation, Hiroshima Prefectural Institute of Industrial Science and Technology
Am J Pathol 160:2191-205. 2002Previously pleiotrophin (PTN) was identified among proteins secreted by Swiss 3T3 cells as a mitogen for cultured adult rat hepatocytes...
- Expression of pleiotrophin in hepatic nonparenchymal cells and preneoplastic nodules in carbon tetrachloride-induced fibrotic rat liverT Kohashi
Department of Biological Science, Graduate School of Science, Hiroshima University, Higashihiroshima, Japan
Growth Factors 20:53-60. 2002b>Pleiotrophin (PTN) is a heparin-binding protein, which induces growth, angiogenesis, differentiation, and transformation of cells. The aim of this study was to examine the role of PTN in liver fibrogenesis...