Pth1r

Summary

Gene Symbol: Pth1r
Description: parathyroid hormone 1 receptor
Alias: PTHrel, Pthr, Pthr1, parathyroid hormone/parathyroid hormone-related peptide receptor, PTH/PTHr receptor, PTH/PTHrP type I receptor, PTH1 receptor, parathyroid hormone receptor 1
Species: rat

Top Publications

  1. ncbi Abnormal renovascular parathyroid hormone-1 receptor in hypertension: Primary defect or secondary to angiotensin ii type 1 receptor activation?
    Sandra Welsch
    Institut National de la Sante et de la Recherche Medicale, Unité 727, Strasbourg F 67085 France
    Endocrinology 147:4384-91. 2006
  2. doi Expression of PTHrP and PTH/PTHrP receptor 1 in the superior cervical ganglia of rats
    Natalija Filipović
    Department of Anatomy, Histology and Embryology, University of Split School of Medicine, Soltanska 2, 21000 Split, Croatia Electronic address
    Neuropeptides 48:353-9. 2014
  3. pmc Regulation of parathyroid hormone type 1 receptor dynamics, traffic, and signaling by the Na+/H+ exchanger regulatory factor-1 in rat osteosarcoma ROS 17/2.8 cells
    David Wheeler
    Department of Pharmacology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    Mol Endocrinol 22:1163-70. 2008
  4. doi Parathyroid hormone signaling in bone and kidney
    Minnkyong Lee
    Department of Physiology and Biophysics, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA
    Curr Opin Nephrol Hypertens 18:298-302. 2009
  5. pmc The parathyroid hormone 1 receptor directly binds to the FERM domain of ezrin, an interaction that supports apical receptor localization and signaling in LLC-PK1 cells
    Matthew J Mahon
    Endocrine Unit, Massachusetts General Hospital, 50 Blossom Street, Their 10, Boston, Massachusetts 02114, USA
    Mol Endocrinol 23:1691-701. 2009
  6. ncbi Calmodulin interacts with the cytoplasmic tails of the parathyroid hormone 1 receptor and a sub-set of class b G-protein coupled receptors
    Matthew J Mahon
    Endocrine Unit, Massachusetts General Hospital, 50 Blossom Street, Wellman 501, Boston, MA 02114 2696, USA
    FEBS Lett 579:803-7. 2005
  7. pmc Molecular basis of parathyroid hormone receptor signaling and trafficking: a family B GPCR paradigm
    Jean Pierre Vilardaga
    Laboratory for GPCR Biology, Department of Pharmacology and Chemical Biology, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Cell Mol Life Sci 68:1-13. 2011
  8. ncbi The parathyroid hormone receptorsome and the potential for therapeutic intervention
    M J Mahon
    Endocrine Unit, Massachusetts General Hospital and Department of Medicine, Harvard Medical School, USA
    Curr Drug Targets 13:116-28. 2012
  9. ncbi Evidence for a ligand interaction site at the amino-terminus of the parathyroid hormone (PTH)/PTH-related protein receptor from cross-linking and mutational studies
    M Mannstadt
    Endocrine Unit, Department of Medicine and Children s Service, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    J Biol Chem 273:16890-6. 1998
  10. ncbi Mutations in the second cytoplasmic loop of the rat parathyroid hormone (PTH)/PTH-related protein receptor result in selective loss of PTH-stimulated phospholipase C activity
    A Iida-Klein
    Endocrine Unit, Massachusetts General Hospital and Department of Medicine, Harvard Medical School, Boston, Massachusetts 02114, USA
    J Biol Chem 272:6882-9. 1997

Research Grants

Scientific Experts

  • Natalija Filipović
  • Jean Pierre Vilardaga
  • Atsuhiko Kato
  • HESHAM A TAWFEEK
  • Ewa Lewin
  • Matthew J Mahon
  • Michio Kuwahara
  • Gyun Jee Song
  • Bin Wang
  • Peter A Friedman
  • Minqi Li
  • Alessandro Bisello
  • Shin Ichi Katsumata
  • Nobuyuki Nishikawa
  • Anja Röthig
  • Alexander Emami-Nemini
  • Juan A Ardura
  • Takashi Doi
  • Norio Amizuka
  • Minnkyong Lee
  • Kimimitsu Oda
  • Sobhan Ubaidus
  • David Wheeler
  • Junko Shimomura-Kuroki
  • Thomas Dean
  • Nathalie Fiaschi-Taesch
  • Eric K Patterson
  • Patricia H Watson
  • Laurence J Fraher
  • Anthony B Hodsman
  • Sandra Welsch
  • Arantxa Ortega
  • Bryce W Pickard
  • Masako Shimada
  • Ritsuko Masuyama
  • Mariko Uehara
  • Kazuharu Suzuki
  • Claudia Gentili
  • Takeshi Okinami
  • Yoshio Sugino
  • Akihiro Kanematsu
  • Masaaki Imamura
  • Koji Yoshimura
  • Hiromitsu Negoro
  • Osamu Ogawa
  • Hikaru Hashitani
  • Christoph Klenk
  • Klaus Dieter Schluter
  • Rolf Schreckenberg
  • Martin J Lohse
  • Charlotte Conzelmann
  • Kerstin Weber
  • Henning Urlaub
  • Antje Gohla
  • Rui Manuel da Costa Rebelo
  • Simon C Watkins
  • Kristen L Leslie
  • Takeyasu Maeda
  • Prem Puri
  • H Juppner
  • Yukie Seki
  • Nathalie M Fiaschi-Taesch
  • Ritsuo Takagi
  • Paulo H L Freitas
  • Junko Shimomura
  • Sara Sultana
  • Reiko Suzuki
  • Jens Dingemann
  • T J Gardella
  • Janet E Henderson
  • Aušra Lukošiūtė
  • Ying Guo
  • Tsuneyuki Yamamoto
  • Stacey Barrick
  • Elke Ruttenstock
  • Zhusheng Liu
  • Brian Sicari
  • Taku Kojima
  • Masaki Nagata
  • Masato Tamura
  • Abdul B Abou-Samra
  • Yanmei Yang
  • Nicola C Partridge
  • Jose Luis Garrido
  • Yoko Ishida
  • John T Potts
  • Shohachi Shimooka
  • Yung Kyu Kim
  • E Schipani
  • Thomas J Gardella

Detail Information

Publications38

  1. ncbi Abnormal renovascular parathyroid hormone-1 receptor in hypertension: Primary defect or secondary to angiotensin ii type 1 receptor activation?
    Sandra Welsch
    Institut National de la Sante et de la Recherche Medicale, Unité 727, Strasbourg F 67085 France
    Endocrinology 147:4384-91. 2006
    ..impaired in mature spontaneously hypertensive rats (SHR) through down-regulation of the type 1 PTH/PTHrP receptor (PTH1R), a feature that contributes to the high renal vascular resistance in SHR...
  2. doi Expression of PTHrP and PTH/PTHrP receptor 1 in the superior cervical ganglia of rats
    Natalija Filipović
    Department of Anatomy, Histology and Embryology, University of Split School of Medicine, Soltanska 2, 21000 Split, Croatia Electronic address
    Neuropeptides 48:353-9. 2014
    PTHrP and its receptor PTHR1 are found in the CNS and peripheral nervous system...
  3. pmc Regulation of parathyroid hormone type 1 receptor dynamics, traffic, and signaling by the Na+/H+ exchanger regulatory factor-1 in rat osteosarcoma ROS 17/2.8 cells
    David Wheeler
    Department of Pharmacology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    Mol Endocrinol 22:1163-70. 2008
    ..regulatory factor-1 (NHERF1) on the distribution, dynamics, and signaling properties of the PTH type 1 receptor (PTH1R) were studied in rat osteosarcoma cells ROS 17/2.8...
  4. doi Parathyroid hormone signaling in bone and kidney
    Minnkyong Lee
    Department of Physiology and Biophysics, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA
    Curr Opin Nephrol Hypertens 18:298-302. 2009
    ..Here, we will review the recent advancements regarding PTH signaling in bone and kidney...
  5. pmc The parathyroid hormone 1 receptor directly binds to the FERM domain of ezrin, an interaction that supports apical receptor localization and signaling in LLC-PK1 cells
    Matthew J Mahon
    Endocrine Unit, Massachusetts General Hospital, 50 Blossom Street, Their 10, Boston, Massachusetts 02114, USA
    Mol Endocrinol 23:1691-701. 2009
    PTH 1 receptor (PTH1R) regulates mineral ion homeostasis. Both apical and basolateral PTH1R subpopulations exist within the renal proximal tubule...
  6. ncbi Calmodulin interacts with the cytoplasmic tails of the parathyroid hormone 1 receptor and a sub-set of class b G-protein coupled receptors
    Matthew J Mahon
    Endocrine Unit, Massachusetts General Hospital, 50 Blossom Street, Wellman 501, Boston, MA 02114 2696, USA
    FEBS Lett 579:803-7. 2005
    Parathyroid hormone (PTH) binds to its receptor (PTH 1 receptor, PTH1R) and activates multiple pathways. The PTH1R, a class b GPCR, contains consensus calmodulin-binding motifs...
  7. pmc Molecular basis of parathyroid hormone receptor signaling and trafficking: a family B GPCR paradigm
    Jean Pierre Vilardaga
    Laboratory for GPCR Biology, Department of Pharmacology and Chemical Biology, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Cell Mol Life Sci 68:1-13. 2011
    The parathyroid hormone (PTH) receptor type 1 (PTHR), a G protein-coupled receptor (GPCR), transmits signals to two hormone systems-PTH, endocrine and homeostatic, and PTH-related peptide (PTHrP), paracrine-to regulate different ..
  8. ncbi The parathyroid hormone receptorsome and the potential for therapeutic intervention
    M J Mahon
    Endocrine Unit, Massachusetts General Hospital and Department of Medicine, Harvard Medical School, USA
    Curr Drug Targets 13:116-28. 2012
    The parathyroid hormone 1 receptor (PTH1R) is activated by parathyroid hormone (PTH) and parathyroid hormone related protein (PTHrP), hormones that mediate mineral ion homeostasis and tissue development, respectively...
  9. ncbi Evidence for a ligand interaction site at the amino-terminus of the parathyroid hormone (PTH)/PTH-related protein receptor from cross-linking and mutational studies
    M Mannstadt
    Endocrine Unit, Department of Medicine and Children s Service, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    J Biol Chem 273:16890-6. 1998
    ..Thus, the convergence of photoaffinity cross-linking and mutational data demonstrates that the extreme amino-terminus of the rP1R participates in ligand binding...
  10. ncbi Mutations in the second cytoplasmic loop of the rat parathyroid hormone (PTH)/PTH-related protein receptor result in selective loss of PTH-stimulated phospholipase C activity
    A Iida-Klein
    Endocrine Unit, Massachusetts General Hospital and Department of Medicine, Harvard Medical School, Boston, Massachusetts 02114, USA
    J Biol Chem 272:6882-9. 1997
    ....
  11. doi Effects of nicotine on PTHrP and PTHrP receptor expression in rat coronary endothelial cells
    Anja Röthig
    Justus Liebig University, Department of Physiology, Giesen, Germany
    Cell Physiol Biochem 29:485-92. 2012
    ..The study was aimed to investigate whether nicotine affects endothelial expression of PTHrP and PTHrP receptor, a peptide system involved in endothelial protection against apoptosis...
  12. doi The guanine nucleotide exchange factor Vav2 is a negative regulator of parathyroid hormone receptor/Gq signaling
    Alexander Emami-Nemini
    Institute of Pharmacology and Toxicology, Rudolf Virchow Center, University of Wurzburg, Versbacher Straße 9, Wurzburg, Germany
    Mol Pharmacol 82:217-25. 2012
    The parathyroid hormone receptor (PTHR) is a class B G protein-coupled receptor (GPCR) that mediates the endocrine and paracrine effects of parathyroid hormone and related peptides through the activation of phospholipase Cβ-, adenylyl ..
  13. ncbi Transmembrane residues of the parathyroid hormone (PTH)/PTH-related peptide receptor that specifically affect binding and signaling by agonist ligands
    T J Gardella
    Endocrine Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    J Biol Chem 271:12820-5. 1996
    ....
  14. doi PTHrP is endogenous relaxant for spontaneous smooth muscle contraction in urinary bladder of female rat
    Nobuyuki Nishikawa
    Department of Urology, Kyoto University Graduate School of Medicine, Kyoto, 606 8507, Japan
    Endocrinology 154:2058-68. 2013
    ..Localization of PTHrP and its functional receptor, PTH/PTHrP receptor 1 (PTH1R), were analyzed in the untreated rat bladders and cultured bladder cells using real-time RT-PCR and immunoblotting,..
  15. pmc Dynamic Na+-H+ exchanger regulatory factor-1 association and dissociation regulate parathyroid hormone receptor trafficking at membrane microdomains
    Juan A Ardura
    Laboratory for G Protein coupled Receptor Biology, Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    J Biol Chem 286:35020-9. 2011
    ..The parathyroid hormone receptor (PTHR), which regulates mineral ion homeostasis and bone turnover, is a G protein-coupled receptor harboring a PDZ-..
  16. pmc EBP50 inhibits the anti-mitogenic action of the parathyroid hormone type 1 receptor in vascular smooth muscle cells
    Gyun Jee Song
    Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15260, USA
    J Mol Cell Cardiol 49:1012-21. 2010
    Parathyroid hormone-related protein (PTHrP) and the parathyroid hormone type 1 receptor (PTH1R) are important regulators of vascular remodeling...
  17. doi FGFR3 down-regulates PTH/PTHrP receptor gene expression by mediating JAK/STAT signaling in chondrocytic cell line
    Minqi Li
    Center for Transdisciplinary Research, Niigata University, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    J Electron Microsc (Tokyo) 59:227-36. 2010
    ..Altogether, these findings suggest that FGFR3 down-regulates PTH/PTHrP receptor gene expression via the JAK/STAT signaling in chondrocytic cells...
  18. doi Disturbance of parathyroid hormone-related protein signaling in the nitrofen-induced hypoplastic lung
    Takashi Doi
    The Children s Research Centre, Our Lady s Children s Hospital, Dublin 12, Ireland
    Pediatr Surg Int 26:45-50. 2010
    ..We designed this study to test the hypothesis that gene expression of PTHrP and PTHrP-R is downregulated in the late stages of lung morphogenesis in the nitrofen-induced hypoplastic lung...
  19. pmc Endogenous parathyroid hormone-related protein regulates the expression of PTH type 1 receptor and proliferation of vascular smooth muscle cells
    Gyun Jee Song
    Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, E1358 Biomedical Science Tower, Pittsburgh, Pennsylvania 15261, USA
    Mol Endocrinol 23:1681-90. 2009
    The PTH type 1 receptor (PTH1R) and PTHrP are expressed in vessels, where they contribute to regulating vascular smooth muscle cell (VSMC) function. Elevated PTHrP levels in VSMC are often associated with hyperplasia...
  20. pmc NHERF1 regulates parathyroid hormone receptor desensitization: interference with beta-arrestin binding
    Bin Wang
    Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Mol Pharmacol 75:1189-97. 2009
    Type 1 parathyroid hormone receptor (PTH1R) activation, desensitization, internalization, and recycling proceed in a cyclical manner...
  21. ncbi Rat wild-type parathyroid hormone receptor (PTH-R) and mutant PTH-R(P132L) show the different intracellular localization in vitro
    Junko Shimomura-Kuroki
    Pediatric Dentistry, The Nippon Dental University, School of Life Dentistry at Niigata, Niigata, Japan
    Biomed Res 29:61-9. 2008
    ..In summary, these findings indicate that defective transport of PTH-R(P132L) to the cell surface would be a molecular basis for Blomstrand's chondrodysplasia...
  22. pmc Negative regulation of parathyroid hormone (PTH)-activated phospholipase C by PTH/PTH-related peptide receptor phosphorylation and protein kinase A
    Hesham A W Tawfeek
    Endocrine Unit, Massachusetts General Hospital, 55 Fruit Street, Thier 1051, Boston, Massachusetts 02114, USA
    Endocrinology 149:4016-23. 2008
    ..Altogether, these data suggest that PTH signaling to PLC is negatively regulated by PTH/PTHrP receptor phosphorylation and PKA. Furthermore, phosphorylation at Ser1105 is demonstrated as a regulatory mechanism of PLCbeta3 by PKA...
  23. ncbi Expression of PTH1R constructs in LLC-PK1 cells: protein nuclear targeting is mediated by the PTH1R NLS
    Eric K Patterson
    Department of Biochemistry, University of Western Ontario, and The Lawson Health Research Institute, London, Ontario, Canada N6A 4V2
    Bone 41:603-10. 2007
    This study demonstrates that the PTH1R NLS can target a fusion protein to the nucleus, and that this is blocked by sequences downstream of the NLS...
  24. pmc Altered selectivity of parathyroid hormone (PTH) and PTH-related protein (PTHrP) for distinct conformations of the PTH/PTHrP receptor
    Thomas Dean
    Endocrine Unit, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Mol Endocrinol 22:156-66. 2008
    PTH and PTHrP use the same G protein-coupled receptor, the PTH/PTHrP receptor (PTHR), to mediate their distinct biological actions. The extent to which the mechanisms by which the two ligands bind to the PTHR differ is unclear...
  25. pmc Expression cloning of a common receptor for parathyroid hormone and parathyroid hormone-related peptide from rat osteoblast-like cells: a single receptor stimulates intracellular accumulation of both cAMP and inositol trisphosphates and increases intracel
    A B Abou-Samra
    Endocrine Unit, Massachusetts General Hospital Harvard Medical School, Boston 02114
    Proc Natl Acad Sci U S A 89:2732-6. 1992
    ..These properties could explain the diversity of PTH action without the need to postulate other receptor subtypes...
  26. ncbi Expression of bone type 1 PTH receptor in rats with chronic renal failure
    Michio Kuwahara
    Division of Nephrology, Shuwa General Hospital, 1200 Yahara Shinden, Kasukabe, Saitama 344 0035, Japan
    Clin Exp Nephrol 11:34-40. 2007
    Some researchers have speculated that a decrease in bone type 1 PTH receptor (PTH1R) may be among the causes of "skeletal resistance" in chronic renal failure (CRF)...
  27. ncbi Role of parathyroid hormone-related protein in tubulointerstitial apoptosis and fibrosis after folic acid-induced nephrotoxicity
    Arantxa Ortega
    Laboratorio de Metabolismo Mineral y Oseo, Pathology Department, Fundación Jiménez and Universidad Autónoma de Madrid, Spain
    J Am Soc Nephrol 17:1594-603. 2006
    ..Our findings indicate that this peptide, by interaction with the PTH1 receptor, can increase tubulointerstitial cell survival and seems to act as a proinflammatory and profibrogenic factor ..
  28. ncbi Type 1 parathyroid hormone receptor (PTH1R) nuclear trafficking: association of PTH1R with importin alpha1 and beta
    Bryce W Pickard
    Department of Physiology, The University of Western Ontario, London, Ontario, Canada N6Q 5B8
    Endocrinology 147:3326-32. 2006
    Previous studies have shown that the type 1 PTH receptor (PTH1R), a class B G protein-coupled receptor, appears in the nucleus of target cells...
  29. ncbi PTHrP and PTH/PTHrP receptor 1 expression in odontogenic cells of normal and HHM model rat incisors
    Atsuhiko Kato
    Safety Assessment Department, Chugai Pharmaceutical Co Ltd, 1 135 Komakado, Gotemba shi, Shizuoka 412 8513, Japan
    Toxicol Pathol 33:456-64. 2005
    ..We examined PTHrP and its receptor (PTHR1) expression patterns in odontogenic cells in normal and HHM model rat incisors...
  30. ncbi The receptor for parathyroid hormone and parathyroid hormone-related peptide is hydrolyzed and its signaling properties are altered by directly binding the calpain small subunit
    Masako Shimada
    Endocrine Unit, Massachusetts General Hospital and Department of Medicine, Harvard Medical School, Boston, Massachusetts 02114, USA
    Endocrinology 146:2336-44. 2005
    We show calcium-dependent, direct binding between the N-terminal portion of the PTH/PTHrP receptor (PTH1R) C-terminal intracellular tail and the calpain small subunit...
  31. ncbi Effect of high phosphorus diet on phosphorus metabolism in parathyroidectomized rats
    Shin Ichi Katsumata
    Department of Nutritional Science, Faculty of Applied Bioscience, Tokyo University of Agriculture, 1 1 1 Sakuragaoka, Setagaya Ku, Tokyo 156 8502, Japan
    Biofactors 22:33-7. 2004
    ..In conclusion, high P diet did not change PTH action in PTX rats and increased urinary excretion of P and bone resorption regardless of PTH action...
  32. ncbi Decreased mRNA expression of the PTH/PTHrP receptor and type II sodium-dependent phosphate transporter in the kidney of rats fed a high phosphorus diet accompanied with a decrease in serum calcium concentration
    Shin Ichi Katsumata
    Department of Nutritional Science, Faculty of Applied Bioscience, Tokyo University of Agriculture, 1 1 1 Sakuragaoka, Setagaya Ku, Tokyo 156 8502, Japan
    Biosci Biotechnol Biochem 68:2484-9. 2004
    ..Furthermore, an increase in the urinary excretion of P might have been caused by decreased NaPi-2 mRNA expression without the effects of PTH and 1,25(OH)(2)D(3)...
  33. ncbi Autoregulation in the parathyroid glands by PTH/PTHrP receptor ligands in normal and uremic rats
    Ewa Lewin
    Nephrological Department B, Herlev Hospital, University of Copenhagen, Copenhagen, Denmark
    Kidney Int 64:63-70. 2003
    ..Our aim was to search for the PTH/PTHrP receptor in rat parathyroid glands and to examine the effects of PTHrP 1-40 on PTH secretion in in vivo models of secondary hyperparathyroidism (HPT) in uremic rats...
  34. ncbi Characterization of PTH/PTHrP receptor in rat duodenum: effects of ageing
    Claudia Gentili
    Departamento de Biologia, Bioquimica and Farmacia, Universidad Nacional del Sur, 8000 Bahia Blanca, Argentina
    J Cell Biochem 88:1157-67. 2003
    In rat enterocytes, signaling through the parathyroid hormone (PTH)/PTH-related peptide receptor type 1(PTHR1) includes stimulation of adenylyl cyclase, increases of intracellular calcium, activation of phospholipase C, and the MAP ..
  35. ncbi Preproparathyroid hormone-related protein, a secreted peptide, is a substrate for the ubiquitin proteolytic system
    K Meerovitch
    Calcium Research Laboratory, Montreal H3A 1A1, Canada
    J Biol Chem 272:6706-13. 1997
    ....
  36. ncbi Constitutively activated receptors for parathyroid hormone and parathyroid hormone-related peptide in Jansen's metaphyseal chondrodysplasia
    E Schipani
    Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    N Engl J Med 335:708-14. 1996
    ..To investigate this and other activating mutations and to refine the classification of this unusual disorder, we analyzed genomic DNA from six additional patients with Jansen's disease...
  37. ncbi The rat, mouse and human genes encoding the receptor for parathyroid hormone and parathyroid hormone-related peptide are highly homologous
    X F Kong
    Endocrine Unit, Massachusetts General Hospital, Boston
    Biochem Biophys Res Commun 200:1290-9. 1994
    ..Therefore, the PTH/PTHrP receptor gene contains alternative 3' sequences that allow cleavage and polyadenylation of its transcript...
  38. ncbi Cloning of a parathyroid hormone/parathyroid hormone-related peptide receptor (PTHR) cDNA from a rat osteosarcoma (UMR 106) cell line: chromosomal assignment of the gene in the human, mouse, and rat genomes
    Z Pausova
    Calcium Research Laboratory, McGill University, Montreal, Quebec, Canada
    Genomics 20:20-6. 1994
    ..DNAs spanning the entire coding region of the rat parathyroid hormone/parathyroid hormone-related peptide receptor (PTHR) were isolated from a rat osteosarcoma (UMR 106) cell-line cDNA library...

Research Grants1

  1. Mitogen activated protein kinases regulation-PTH/PTHrP
    Hesham Tawfeek; Fiscal Year: 2008
    ..Primary osteoblastic cell culture from wild type and genetically engineered mice as well as several other biochemical and pharmacological tools will be employed to achieve the goals of the study. ..