Ptgs2

Summary

Gene Symbol: Ptgs2
Description: prostaglandin-endoperoxide synthase 2
Alias: COX-2, Cox2, prostaglandin G/H synthase 2, PGH synthase 2, PGHS-2, PHS II, cyclooxygenase-2, prostaglandin H2 synthase 2
Species: rat

Top Publications

  1. ncbi Bradykinin-induced nociceptor sensitisation to heat depends on cox-1 and cox-2 in isolated rat skin
    Steffi Mayer
    Department of Physiology and Pathophysiology, Friedrich Alexander University of Erlangen Nuremberg, Universitaetsstr 17, D 91054 Erlangen, Germany
    Pain 130:14-24. 2007
  2. pmc Candida albicans induces cyclo-oxygenase 2 expression and prostaglandin E2 production in synovial fibroblasts through an extracellular-regulated kinase 1/2 dependent pathway
    Herng Sheng Lee
    Department of Pathology, Tri Service General Hospital and National Defense Medical Center, Neihu District, Taipei City, Taiwan
    Arthritis Res Ther 11:R48. 2009
  3. pmc Induction of COX-2 enzyme and down-regulation of COX-1 expression by lipopolysaccharide (LPS) control prostaglandin E2 production in astrocytes
    Miriam Font-Nieves
    Department of Brain Ischemia and Neurodegeneration, Institute for Biomedical Research of Barcelona, Consejo Superior de Investigaciones Cientificas, Institut d Investigacions Biomediques August Pi i Sunyer, 08036 Barcelona, Spain
    J Biol Chem 287:6454-68. 2012
  4. ncbi Cyclooxygenase (COX)-1 expressing macrophages/microglial cells and COX-2 expressing astrocytes accumulate during oligodendroglioma progression
    M H Deininger
    Institute of Brain Research, University of Tuebingen, Medical School, Tuebingen, Germany
    Brain Res 885:111-6. 2000
  5. pmc Increased neuroinflammatory and arachidonic acid cascade markers, and reduced synaptic proteins, in brain of HIV-1 transgenic rats
    Jagadeesh Sridhara Rao
    Brain Physiology and Metabolism Section, National Institute on Aging, Bethesda, MD 20892, USA
    J Neuroinflammation 8:101. 2011
  6. ncbi Expression and localization of cyclooxygenase-1 and -2 in human sporadic amyotrophic lateral sclerosis
    Christian Maihofner
    Department of Neurology, University of Erlangen Nuremberg, Schwabachanlage 6, Erlangen, Germany
    Eur J Neurosci 18:1527-34. 2003
  7. doi The obligatory role of COX-2 expression for induction of HO-1 in ischemic preconditioned rat brain
    Min Kyu Park
    Department of Pharmacology, School of Medicine and Institute of Health Sciences, Gyeongsang National University, 92 Chilam dong, Jinju 660 751, Republic of Korea
    Biochem Biophys Res Commun 377:1191-4. 2008
  8. ncbi The proximal region of the 3'-untranslated region of cyclooxygenase-2 is recognized by a multimeric protein complex containing HuR, TIA-1, TIAR, and the heterogeneous nuclear ribonucleoprotein U
    Steven J Cok
    Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 278:36157-62. 2003
  9. ncbi Involvement of cyclooxygenase-1 and -2 in the sciatic nerve of rats with experimental autoimmune neuritis
    Taekyun Shin
    Department of Veterinary Medicine, College of Agriculture and Life Science, Cheju National University, Jeju, South Korea
    Immunol Invest 32:123-30. 2003
  10. ncbi Nitric oxide induces apoptosis via AP-1-driven upregulation of COX-2 in rat pheochromocytoma cells
    Mei Hua Li
    National Research Laboratory of Molecular Carcinogenesis and Chemoprevention, College of Pharmacy, Seoul National University, Shinlim Dong, Kwanak Ku, Seoul 151 742, South Korea
    Free Radic Biol Med 39:890-9. 2005

Research Grants

Detail Information

Publications186 found, 100 shown here

  1. ncbi Bradykinin-induced nociceptor sensitisation to heat depends on cox-1 and cox-2 in isolated rat skin
    Steffi Mayer
    Department of Physiology and Pathophysiology, Friedrich Alexander University of Erlangen Nuremberg, Universitaetsstr 17, D 91054 Erlangen, Germany
    Pain 130:14-24. 2007
    ..This study shows that both cox isoforms are present in skin and that they have an important role in mediating bradykinin-evoked heat sensitisation of C-MH sensitive fibres through cox-1 and cox-2 dependent prostaglandin synthesis...
  2. pmc Candida albicans induces cyclo-oxygenase 2 expression and prostaglandin E2 production in synovial fibroblasts through an extracellular-regulated kinase 1/2 dependent pathway
    Herng Sheng Lee
    Department of Pathology, Tri Service General Hospital and National Defense Medical Center, Neihu District, Taipei City, Taiwan
    Arthritis Res Ther 11:R48. 2009
    ..Synovial cells are potential sources of inflammatory mediators in bacterial-induced arthritis but their involvement in the inflammatory response to Candida albicans-induced septic arthritis is largely unknown...
  3. pmc Induction of COX-2 enzyme and down-regulation of COX-1 expression by lipopolysaccharide (LPS) control prostaglandin E2 production in astrocytes
    Miriam Font-Nieves
    Department of Brain Ischemia and Neurodegeneration, Institute for Biomedical Research of Barcelona, Consejo Superior de Investigaciones Cientificas, Institut d Investigacions Biomediques August Pi i Sunyer, 08036 Barcelona, Spain
    J Biol Chem 287:6454-68. 2012
    ..These effects might induce cerebral blood flow responses to brain inflammation...
  4. ncbi Cyclooxygenase (COX)-1 expressing macrophages/microglial cells and COX-2 expressing astrocytes accumulate during oligodendroglioma progression
    M H Deininger
    Institute of Brain Research, University of Tuebingen, Medical School, Tuebingen, Germany
    Brain Res 885:111-6. 2000
    ..0471) lower in primary oligodendrogliomas than in high grade oligodendroglioma relapses. These data provide convincing evidence for the differential accumulation of cyclooxygenase isoforms during oligodendroglioma progression in vivo...
  5. pmc Increased neuroinflammatory and arachidonic acid cascade markers, and reduced synaptic proteins, in brain of HIV-1 transgenic rats
    Jagadeesh Sridhara Rao
    Brain Physiology and Metabolism Section, National Institute on Aging, Bethesda, MD 20892, USA
    J Neuroinflammation 8:101. 2011
    ..We recently reported upregulated brain AA metabolism in 7- to 9-month-old HIV-1 Tg rats. We hypothesized that these HIV-1 Tg rats also would show upregulated brain inflammatory and AA cascade markers and a deficit of synaptic proteins...
  6. ncbi Expression and localization of cyclooxygenase-1 and -2 in human sporadic amyotrophic lateral sclerosis
    Christian Maihofner
    Department of Neurology, University of Erlangen Nuremberg, Schwabachanlage 6, Erlangen, Germany
    Eur J Neurosci 18:1527-34. 2003
    ..Selective COX-2 inhibition might therefore offer a new possibility in the treatment of human ALS. However, to determine the exact role of COX-2 in human ALS will require further research...
  7. doi The obligatory role of COX-2 expression for induction of HO-1 in ischemic preconditioned rat brain
    Min Kyu Park
    Department of Pharmacology, School of Medicine and Institute of Health Sciences, Gyeongsang National University, 92 Chilam dong, Jinju 660 751, Republic of Korea
    Biochem Biophys Res Commun 377:1191-4. 2008
    ..Taken together, we conclude that the kinetic changes in COX-2 induction during the reperfusion period following preconditioning may be important for ischemic tolerance...
  8. ncbi The proximal region of the 3'-untranslated region of cyclooxygenase-2 is recognized by a multimeric protein complex containing HuR, TIA-1, TIAR, and the heterogeneous nuclear ribonucleoprotein U
    Steven J Cok
    Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 278:36157-62. 2003
    ..Therefore, we propose that HuR binds to the proximal region of the 3'-UTR of COX-2 following stimulation by IL-1beta and increases the expression of COX-2 mRNA by facilitating its transport out of the nucleus...
  9. ncbi Involvement of cyclooxygenase-1 and -2 in the sciatic nerve of rats with experimental autoimmune neuritis
    Taekyun Shin
    Department of Veterinary Medicine, College of Agriculture and Life Science, Cheju National University, Jeju, South Korea
    Immunol Invest 32:123-30. 2003
    ..Furthermore, COX-2 is enhanced in some Schwann cells and neural elements, possibly mediating peripheral nervous system inflammation...
  10. ncbi Nitric oxide induces apoptosis via AP-1-driven upregulation of COX-2 in rat pheochromocytoma cells
    Mei Hua Li
    National Research Laboratory of Molecular Carcinogenesis and Chemoprevention, College of Pharmacy, Seoul National University, Shinlim Dong, Kwanak Ku, Seoul 151 742, South Korea
    Free Radic Biol Med 39:890-9. 2005
    ..These results suggest that excessive NO production during inflammation induces apoptosis in PC12 cells through AP-1-mediated upregulation of COX-2 expression...
  11. ncbi Chronic inhibition of NOS-2 ameliorates renal injury, as well as COX-2 and TGF-beta 1 overexpression in 5/6 nephrectomized rats
    Pablo Bautista-García
    Department of Nephrology, Instituto Nacional de Cardiologia Ignacio Chavez, Juan Badiano 1, 14080 Mexico City, Mexico
    Nephrol Dial Transplant 21:3074-81. 2006
    ..Thus, we studied the contribution of NOS-2 to the expression levels of COX-2 and TGF-beta1, as well as the structural renal injury in rats with subtotal renal ablation (5/6 Nx)...
  12. ncbi Intrathecally administered COX-2 but not COX-1 or COX-3 inhibitors attenuate streptozotocin-induced mechanical hyperalgesia in rats
    Aki Matsunaga
    Department of Anesthesiology and Critical Care, Division of Clinical Medical Science, Graduate School of Biomedical Science, Hiroshima University
    Eur J Pharmacol 554:12-7. 2007
    ....
  13. ncbi Sphingosine 1-phosphate induces cyclooxygenase-2 via Ca2+-dependent, but MAPK-independent mechanism in rat vascular smooth muscle cells
    Akiko Nodai
    Department of Pharmacology, Faculty of Pharmaceutical Sciences, Health Sciences University of Hokkaido, Ishikari Tobetsu, Hokkaido 061 0293, Japan
    Life Sci 80:1768-76. 2007
    ..These results suggest that S1P stimulates COX-2 induction in rat VSMCs through mechanisms involving Ca(2+)-dependent PKC and Src-family tyrosine kinase activation via S1P(3) receptor coupled to PTX-sensitive and -insensitive G proteins...
  14. doi COX-2, but not COX-1, activity is necessary for the induction of perforant path long-term potentiation and spatial learning in vivo
    T R Cowley
    Trinity College Institute of Neuroscience, Trinity College, Dublin 2, Ireland
    Eur J Neurosci 27:2999-3008. 2008
    ..We conclude that endogenous basal levels of PGE(2) resulting from COX-2 but not COX-1 activity are necessary for synaptic plasticity and memory acquisition...
  15. doi Signaling pathways involved in sphingosine kinase activation and sphingosine-1-phosphate release in rat myometrium in late pregnancy: role in the induction of cyclooxygenase 2
    Martin Serrano-Sanchez
    Signalisation et Régulations Cellulaires, Institut de Biochimie et de Biophysique Moleculaire et Cellulaire, Unité Mixte de Recherche 8619, Centre National de la Recherche Scientifique, Batiment 430, Universite Paris Sud, 91405 Orsay, France
    Endocrinology 149:4669-79. 2008
    ..Inhibition of PKC and ERK reduced SphK1/2 activity. In late pregnancy, levels of cyclooxygenase 2 (COX2) increased in parallel to SphK levels...
  16. pmc Hypotonicity-induced Renin exocytosis from juxtaglomerular cells requires aquaporin-1 and cyclooxygenase-2
    Ulla G Friis
    Department of Physiology and Pharmacology, Institute of Medical Biology, University of Southern Denmark, DK 5000 Odense, Denmark
    J Am Soc Nephrol 20:2154-61. 2009
    ....
  17. pmc Effects of genetic deficiency of cyclooxygenase-1 or cyclooxygenase-2 on functional and histological outcomes following traumatic brain injury in mice
    Matthew L Kelso
    Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, KY, USA
    BMC Neurosci 10:108. 2009
    ..The purpose of the current study was to determine the role of the COX isoforms in contributing to pathological processes resulting from TBI by utilizing mice deficient in COX-1 or COX-2...
  18. doi EV71 induces COX-2 expression via c-Src/PDGFR/PI3K/Akt/p42/p44 MAPK/AP-1 and NF-kappaB in rat brain astrocytes
    Wei Hsuan Tung
    Department of Physiology and Pharmacology, Chang Gung University, Kwei San, Tao Yuan, Taiwan
    J Cell Physiol 224:376-86. 2010
    ..These results demonstrate that in RBA-1 cells, EV71-induced COX-2 expression associated with PGE(2) production is mediated through activation of c-Src/PDGFR/PI3K/Akt/p42/p44 MAPK to initiate the expression of AP-1...
  19. doi Co-overexpression of cyclooxygenase-2 and microsomal prostaglandin E synthase-1 adversely affects the postoperative survival in non-small cell lung cancer
    Yu Chung Wu
    Division of Thoracic Surgery, Department of Surgery, Taipei Veterans General Hospital, Taipei, Taiwan
    J Thorac Oncol 5:1167-74. 2010
    ..The aim of this study was to investigate the expression profiles of COX-2 and mPGES-1 and their correlation with the clinical characteristics and survival outcomes in patients with resected NSCLC...
  20. pmc Expression of COX-1 and COX-2 in the endometrium of cyclic, pregnant and in a model of pseudopregnant rats and their regulation by sex steroids
    Isabelle St-Louis
    Department of Chemistry Biology, Universite du Quebec a Trois Rivieres, Trois Rivieres, Quebec, Canada
    Reprod Biol Endocrinol 8:103. 2010
    ..The aim of the present study was to investigate the expression and regulation of COX-1 and COX-2 and levels of prostaglandins during rat pregnancy, in a model of pseudopregnancy and estrous cycle...
  21. doi Diclofenac, a selective COX-2 inhibitor, inhibits DMH-induced colon tumorigenesis through suppression of MCP-1, MIP-1α and VEGF
    Jasmeet Kaur
    Department of Biophysics, Panjab University, Chandigarh, India
    Mol Carcinog 50:707-18. 2011
    ..Our results indicate potential role of chemokines alongwith VEGF in angiogenesis in DMH-induced cancer and its chemoprevention with diclofenac...
  22. doi Type 1 diabetes-induced hyper-responsiveness to 5-hydroxytryptamine in rat pulmonary arteries via oxidative stress and induction of cyclooxygenase-2
    Jose G Lopez-Lopez
    Instituto de Fisiologia, Benemerita Universidad Autonoma de Puebla, Puebla, Mexico
    J Pharmacol Exp Ther 338:400-7. 2011
    ..Our results further strengthen the link between diabetes and pulmonary arterial hypertension...
  23. doi Oligomers of β-amyloid protein (Aβ1-42) induce the activation of cyclooxygenase-2 in astrocytes via an interaction with interleukin-1β, tumour necrosis factor-α, and a nuclear factor κ-B mechanism in the rat brain
    I Carrero
    Laboratory of Neuroanatomy, Institute of Neuroscience of Castilla and Leon, Valladolid University Campus of Soria, Spain
    Exp Neurol 236:215-27. 2012
    ....
  24. ncbi Altered expression of COX-1, COX-2, and mPGES in rats with nephrogenic and central diabetes insipidus
    Primoz Kotnik
    The Water and Salt Research Center, University of Aarhus, DK 8000 Aarhus C, Denmark
    Am J Physiol Renal Physiol 288:F1053-68. 2005
    ..These results identify markedly reduced expression of COX-1, COX-2, and mPGES in IM in lithium-induced NDI. Furthermore, there were major changes in the expression of COX-1, COX-2, and mPGES in rats with CDI...
  25. ncbi Cyclo-oxygenase-1 and -2 differently contribute to prostaglandin E2 synthesis and lipid peroxidation after in vivo activation of N-methyl-D-aspartate receptors in rat hippocampus
    Olimpia Pepicelli
    Department of Cell Biology and Neurosciences, Istituto Superiore di Sanita, Rome, Italy
    J Neurochem 93:1561-7. 2005
    ..We suggest that both isoforms should be considered as possible therapeutic targets to prevent brain damage caused by excitotoxicity...
  26. ncbi Increased gene expression and production of spinal cyclooxygenase 1 and 2 during experimental osteoarthritis pain
    M Prochazkova
    Department of Pharmacology, Third Faculty of Medicine, Charles University, Prague, Czech Republic
    Physiol Res 58:419-25. 2009
    ..Thus, in contrast to inflammatory pain, the upregulation of spinal COX-1 may be important in osteoarthritis pain...
  27. pmc Localization of COX-1 and COX-2 in the intracranial dura mater of the rat
    Xi Chun Zhang
    Department of Anesthesia, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, United States
    Neurosci Lett 452:33-6. 2009
    ..The findings suggest that NSAIDs may abort headache, at least in part, by inhibiting either neuronal or non-neuronal COX activity in the dura mater...
  28. ncbi Regulation of MDR-1 (P-glycoprotein) by cyclooxygenase-2
    Vimal A Patel
    Department of Medicine, Division of Nephrology and the Cardiovascular Research Center, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    J Biol Chem 277:38915-20. 2002
    ..These results prove the existence of a causal link between Cox-2 and P-gp activity, which would have implications for kidney function and multidrug resistance in tumors where Cox-2 is overexpressed...
  29. ncbi Specific roles of cyclooxygenase-1 and cyclooxygenase-2 in lipopolysaccharide-induced fever and Fos expression in rat brain
    Yi Hong Zhang
    Department of Neurology and Program in Neuroscience, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Comp Neurol 463:3-12. 2003
    ..Although COX-2 plays a dominant role in mediating fever responses to i.v. LPS, at least some components of the response, including avoiding hypothermia and the induction of Fos in the NTS, VLM, PB, and PVH, appear to depend on COX-1. J...
  30. ncbi Cellular prostaglandin E2 production by membrane-bound prostaglandin E synthase-2 via both cyclooxygenases-1 and -2
    Makoto Murakami
    Department of Health Chemistry, School of Pharmaceutical Sciences, Showa University, 1 5 8 Hatanodai, Shinagawa ku, Tokyo 142 8555, Japan
    J Biol Chem 278:37937-47. 2003
    ..Collectively, mPGES-2 is a unique PGES that can be coupled with both COXs and may play a role in the production of the PGE2 involved in both tissue homeostasis and disease...
  31. ncbi Free radicals and the pathogenesis of type 1 diabetes: beta-cell cytokine-mediated free radical generation via cyclooxygenase-2
    Tahereh Tabatabaie
    Free Radical Biology and Aging Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, USA
    Diabetes 52:1994-9. 2003
    ..We have also demonstrated that cytokine treatment leads to the activation of NF-kappaB in the pancreatic islets of the rats...
  32. ncbi Cyclooxygenase-1 and 2 in normal and malignant human ovarian epithelium
    Shuanfang Li
    Laboratory of Women s Health, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Gynecol Oncol 92:622-7. 2004
    ..The present study determines whether COX-1 and COX-2 are expressed in ovarian cancers and whether the pattern of expression of these enzymes reveals clues to their roles in this cancer...
  33. ncbi Contrasting effects of cyclooxygenase-1 (COX-1) and COX-2 deficiency on the host response to influenza A viral infection
    Michelle A Carey
    Laboratory of Respiratory Biology, Division of Intramural Research, National Institute of Environmental Health Sciences NIEHS, National Institutes of Health NIH, Research Triangle Park, NC 27709, USA
    J Immunol 175:6878-84. 2005
    ..COX-1 deficiency is detrimental whereas COX-2 deficiency is beneficial to the host during influenza viral infection...
  34. ncbi A novel animal model to investigate fractionated radiotherapy-induced alimentary mucositis: the role of apoptosis, p53, nuclear factor-kappaB, COX-1, and COX-2
    Ann S J Yeoh
    Department of Medical Oncology, Royal Adelaide Hospital, South Australia, Australia
    Mol Cancer Ther 6:2319-27. 2007
    ..Further studies investigating the molecular mechanisms underlying radiation-induced mucositis are planned to ultimately achieve anti-mucotoxic-targeted therapies...
  35. doi Cyclooxygenases 1 and 2 contribute to peroxynitrite-mediated inflammatory pain hypersensitivity
    Michael M Ndengele
    Department of Internal Medicine, Division of Pulmonary, Critical Care and Sleep Medicine, 1402 S Grand Blvd, Deslodge Towers, 7th Floor, Saint Louis University School of Medicine, St Louis, MO 63104 1028, USA
    FASEB J 22:3154-64. 2008
    ....
  36. pmc Thromboxane A(2) contributes to the mediation of flow-induced responses of skeletal muscle venules: role of cyclooxygenases 1 and 2
    A Racz
    Department of Pathophysiology, Semmelweis University, Budapest, Hungary
    J Vasc Res 46:397-405. 2009
    ..We hypothesized that - in addition to nitric oxide (NO) and dilator prostaglandins (PGI(2)/ PGE(2)) - thromboxane A(2) (TxA(2)) contributes to the mediation of flow-induced responses of venules...
  37. pmc Cyclooxygenase-1 or -2--which one mediates lipopolysaccharide-induced hypothermia?
    Alexandre A Steiner
    Systemic Inflammation Laboratory, Trauma Research, St Joseph s Hospital and Medical Center, 350 W Thomas Road, Phoenix, AZ 85013, USA
    Am J Physiol Regul Integr Comp Physiol 297:R485-94. 2009
    ..The expression of splenic COX-1 was unaffected by LPS. We conclude that COX-1, but not COX-2, mediates LPS hypothermia, and that both COX isoforms are required for LPS hypotension...
  38. ncbi Cloning two isoforms of rat cyclooxygenase: differential regulation of their expression
    L Feng
    Department of Immunology, Scripps Research Institute, La Jolla, California 92037
    Arch Biochem Biophys 307:361-8. 1993
    ..Thus, the two COX isoforms were differentially expressed, and COX-2 was selectively induced in response to inflammatory stimuli in rats...
  39. ncbi Expression of a mitogen-inducible cyclooxygenase in brain neurons: regulation by synaptic activity and glucocorticoids
    K Yamagata
    Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205 2185
    Neuron 11:371-86. 1993
    ..Our studies indicate that COX-2 expression may be important in regulating prostaglandin signaling in brain. The marked inducibility in neurons by synaptic stimuli suggests a role in activity-dependent plasticity...
  40. ncbi Cyclooxygenase regulates angiogenesis induced by colon cancer cells
    M Tsujii
    Department of Medicine, Vanderbilt University Medical Center, VA Medical Center, Nashville, Tennessee 37232, USA
    Cell 93:705-16. 1998
    ..Cyclooxygenase regulates colon carcinoma-induced angiogenesis by two mechanisms: COX-2 can modulate production of angiogenic factors by colon cancer cells, while COX-1 regulates angiogenesis in endothelial cells...
  41. ncbi Cyclo-oxygenase-2 contributes to central sensitization in rats with peripheral inflammation
    Virginia S Seybold
    Department of Neuroscience, University of Minnesota, 6 145 Jackson Hall, 321 Church St, S E, Minneapolis, MN 55455, USA
    Pain 105:47-55. 2003
    ..These results indicate that products of COX-2 contribute to the increased excitability of the spinal cord during persistent peripheral inflammation...
  42. ncbi Expression of cyclooxygenase-1 and -2 in human breast cancer
    Norio Yoshimura
    Department of Organ Transplant and Endocrinological Surgery, Kyoto Prefectural University of Medicine, 465 Hirokoji, Kawaramachi, Kamigyo ku, 602 0841 Kyoto, Japan
    Surg Today 33:805-11. 2003
    ..We investigated the expression of cyclooxygenase (Cox-1 and Cox-2) in mammary tissues from patients with breast cancer...
  43. ncbi COX-2 oxidative metabolite of endocannabinoid 2-AG enhances excitatory glutamatergic synaptic transmission and induces neurotoxicity
    Nan Sang
    Neuroscience Center of Excellence, School of Medicine, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112, USA
    J Neurochem 102:1966-77. 2007
    ..Our results suggest that the COX-2 oxidative metabolism of endocannabinoids is an important mechanism contributing to the inflammation-induced neurodegeneration...
  44. ncbi Inducible nitric oxide synthase and cyclooxygenase-2 participate in anti-inflammatory and analgesic effects of the natural marine compound lemnalol from Formosan soft coral Lemnalia cervicorni
    Yen Hsuan Jean
    Section of Orthopedic Surgery, Pingtung Christian Hospital, 60 Da Lan Road, Pingtung 900, Taiwan
    Eur J Pharmacol 578:323-31. 2008
    ..In addition, inhibition of elevated iNOS and COX-2 protein expression as well as neurophil infiltration of carrageenan-injected paws may be involved in the beneficial effects of lemnalol...
  45. doi Cardiac remodelling hinders activation of cyclooxygenase-2, diminishing protection by delayed pharmacological preconditioning: role of HIF1 alpha and CREB
    Jianhua Feng
    Cardiovascular Anesthesia Research Laboratory, Center of Clinical Research, Institute of Anesthesiology, E HOF, University Hospital Zurich, Ramistrasse 100, Zurich CH 8091, Switzerland
    Cardiovasc Res 78:98-107. 2008
    ..We tested whether delayed pharmacologic preconditioning elicited by isoflurane is protective in infarct-remodelled hearts...
  46. pmc Prostaglandin E2 glycerol ester, an endogenous COX-2 metabolite of 2-arachidonoylglycerol, induces hyperalgesia and modulates NFkappaB activity
    S Shu Jung Hu
    Department of Psychological and Brain Sciences, The Gill Center for Biomolecular Science, Indiana University, Bloomington, IN, USA
    Br J Pharmacol 153:1538-49. 2008
    ..We examined whether prostaglandin E2 glycerol ester (PGE2-G), a COX-2 metabolite of 2-AG, occurs endogenously and affects nociception and immune responses...
  47. pmc Oxidative stress and COX cause hyper-responsiveness in vascular smooth muscle of the femoral artery from diabetic rats
    Y Shi
    Department of Pharmacology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China
    Br J Pharmacol 154:639-51. 2008
    ..To investigate the dysfunction of vascular smooth muscle in streptozotocin-induced diabetic rats...
  48. pmc Endocannabinoid 2-arachidonoylglycerol protects neurons by limiting COX-2 elevation
    Jian Zhang
    Neuroscience Center of Excellence, School of Medicine, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112, USA
    J Biol Chem 283:22601-11. 2008
    ....
  49. doi [A cyclooxygenase-2 selective inhibitor worsens respiratory function and enhances mast cell activity in ovalbumin-sensitized mice]
    Rosa Torres
    Departamento de Farmacologia, Universitat Autonoma de Barcelona, Barcelona, Espana
    Arch Bronconeumol 45:162-7. 2009
    ..In order to elucidate the mechanisms involved, we evaluated the impact of selective inhibition of COX-2 with rofecoxib during ovalbumin challenge, assessing mast cell activity and airway response in a murine model of asthma...
  50. ncbi COX-2 inhibition attenuates cough reflex sensitivity to inhaled capsaicin in patients with asthma
    Y Ishiura
    Department of Internal Medicine, Toyama City Hospital, Toyama, Japan
    J Investig Allergol Clin Immunol 19:370-4. 2009
    ..This study was designed to investigate the role of COX-2 in cough reflex sensitivity in patients with asthma...
  51. pmc Overexpression of cyclooxygenase-2 in rat oral cancers and prevention of oral carcinogenesis in rats by selective and nonselective COX inhibitors
    David L McCormick
    IIT Research Institute, Chicago, IL 60616, USA
    Cancer Prev Res (Phila) 3:73-81. 2010
    ..The chemopreventive activity of COX inhibitors may be linked to overexpression of their enzymatic target in incipient oral neoplasms...
  52. ncbi Cyclooxygenase-2 overexpression inhibits platelet-derived growth factor-induced mesangial cell proliferation through induction of the tumor suppressor gene p53 and the cyclin-dependent kinase inhibitors p21waf-1/cip-1 and p27kip-1
    Gunther Zahner
    Department of Medicine, Division of Nephrology and Osteology, University of Hamburg, 20246 Hamburg, Germany
    J Biol Chem 277:9763-71. 2002
    ..These data suggest that COX-2 inhibits mesangial cell proliferation by a novel mechanism that is independent of prostaglandin synthesis, but involves p53, p21(cip-1), and p27(kip-1)...
  53. ncbi Role for both spinal cord COX-1 and COX-2 in maintenance of mechanical hypersensitivity following peripheral nerve injury
    Weiya Ma
    Pain Mechanisms Laboratory, Department of Anesthesiology and Center for the Study of Pharmacologic Plasticity in the Presence of Pain, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157 1009, USA
    Brain Res 937:94-9. 2002
    ..Inhibition of spinal COX may be an important mechanism of action in treating some patients with neuropathic pain following peripheral nerve injury...
  54. ncbi Cyclooxygenase-2 (Cox-2) in injured human nerve and a rat model of nerve injury
    Pascal F Durrenberger
    Peripheral Neuropathy Unit, Imperial College, Hammersmith Hospital, London, UK
    J Peripher Nerv Syst 9:15-25. 2004
    ..Selection of patients 4-6 weeks after nerve injury would be more likely to show any efficacy of Cox-2 inhibitors...
  55. ncbi Cyclooxygenase 2 expression in the spared nerve injury model of neuropathic pain
    D C Broom
    Department of Anesthesia and Critical Care, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA
    Neuroscience 124:891-900. 2004
    ..The pain hypersensitivity produced by the SNI model is not COX-2-dependent...
  56. ncbi Cyclooxygenases mRNA and protein expression in striata in the experimental mouse model of Parkinson's disease induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine administration to mouse
    Adam Przybyłkowski
    Department of Clinical and Experimental Pharmacology, Medical University of Warsaw, Warsaw, Poland
    Brain Res 1019:144-51. 2004
    ..However, COX-2 mRNA and protein expressions increase after MPTP injury; the role of these findings remains obscure...
  57. pmc Upregulation of COX-1 and COX-2 in nasal polyps in cystic fibrosis
    J Roca-Ferrer
    Institut d Investigaccions Biomèdiques, August Pi Syuner, IDIBAPS, Barcelona, Spain
    Thorax 61:592-6. 2006
    ..Since abnormalities in prostanoid metabolism occur in the lower airway of patients with cystic fibrosis (CF), it is likely that they could also be detected in the nose...
  58. ncbi Aggravation by selective COX-1 and COX-2 inhibitors of dextran sulfate sodium (DSS)-induced colon lesions in rats
    Mitsuaki Okayama
    Department of Pharmacology and Experimental Therapeutics, Kyoto Pharmaceutical University, Misasagi, Yamashina, Kyoto 607 8414, Japan
    Dig Dis Sci 52:2095-103. 2007
    ....
  59. ncbi Cyclooxygenase-2 activity following traumatic brain injury in the developing rat
    Robert W Hickey
    Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    Pediatr Res 62:271-6. 2007
    ..Treatment with the COX-2 inhibitor SC58125 in PND17 rats exposed to CCI attenuated the rise in PGE2 but did not attenuate lesion volume or improve performance in the Morris water maze...
  60. ncbi Transient glucose deprivation causes upregulation of heme oxygenase-1 and cyclooxygenase-2 expression in cardiac fibroblasts
    Kenji Takeda
    Division of Cardiology, Kanazawa Medical University, 1 1 Daigaku, Uchinada, Ishikawa 920 0293, Japan
    J Mol Cell Cardiol 36:821-30. 2004
    ....
  61. ncbi Cyclooxygenase-2 expression in Schwann cells and macrophages in the sciatic nerve after single spinal nerve injury in rats
    Masahiro Takahashi
    Department of Anesthesiology, Nara Medical University, Kashihara, Nara 634 8521, Japan
    Neurosci Lett 363:203-6. 2004
    ..These results suggested that the cellular sources of COX-2 expression might be different between the early and late phases after nerve injury...
  62. doi The effects of intrathecal cyclooxygenase-1, cyclooxygenase-2, or nonselective inhibitors on pain behavior and spinal Fos-like immunoreactivity
    Il Ok Lee
    Department of Anesthesiology, 97 Guro Dong Gil, Guro Gu, Korea University Guro Hospital, College of Medicine, Korea University, Seoul, Korea 152 703
    Anesth Analg 106:972-7, table of contents. 2008
    ..Fos expression is an indicator of spinal neuron activation. We examined the role of intrathecal selective and nonspecific COX inhibitors on spinal C-Fos expression...
  63. ncbi Purification and characterization of a novel, distinct isoform of prostaglandin endoperoxide synthase induced by human chorionic gonadotropin in granulosa cells of rat preovulatory follicles
    J Sirois
    Department of Cell Biology, Baylor College of Medicine, Houston, Texas 77030
    J Biol Chem 267:6382-8. 1992
    ....
  64. ncbi Cyclooxygenases-1 and -2 are differentially localized to microglia and endothelium in rat EAE and glioma
    M H Deininger
    Institute of Brain Research, University of Tuebingen, Medical School, Germany
    J Neuroimmunol 95:202-8. 1999
    ....
  65. pmc NF-kappa B binding activity and cyclooxygenase-2 expression in persistent CCl(4)-treated rat liver injury
    Sang Hyun Kim
    Department of Medicine, Pusan National University College of Medicine, Busan, Korea
    J Korean Med Sci 17:193-200. 2002
    ..It could be suggested that ROS produced by CCl(4) treatment increased NF-kappa B binding activity and thereby COX-2 expression, and these might be implicated in the progress of chronic liver damage...
  66. ncbi Mineralocorticoid regulation of cyclooxygenase-2 expression in rat renal medulla
    Ming Zhi Zhang
    George O Brien Center for Kidney and Urologic Diseases, Department of Cell Biology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    Am J Physiol Renal Physiol 283:F509-16. 2002
    ..Together, these results suggest that mineralocorticoids lead to upregulation of COX-2 in rat renal medulla by indirect pathways, probably involving induced electrolyte hypertonicity in the interstitial fluid...
  67. ncbi Expression of cyclooxygenase 2 and prostaglandin E synthase after renal ischemia-reperfusion
    M A A Slimane
    Laboratoire de Chirurgie Expérimentale Faculté de Médecine Paris Sud, Le Kremlin Bicetre, France
    Transplant Proc 34:2841-2. 2002
  68. ncbi Cyclooxygenase-2 inhibits tumor necrosis factor alpha-mediated apoptosis in renal glomerular mesangial cells
    Adiba Ishaque
    Department of Medicine and Cardiovascular Research Center, Medical College of Wisconsin, Milwaukee 53226, USA
    J Biol Chem 278:10629-40. 2003
    ..These results demonstrate COX-2 anti-apoptotic activity via a death receptor route and suggest that selective COX-2 inhibition may augment TNFalpha apoptosis in chronic inflammatory conditions...
  69. ncbi Down-regulation of cyclooxygenase-2 expression but up-regulation of cyclooxygenase-1 in renal carcinomas of the Eker (TSC2 gene mutant) rat model
    Toshihiro Okamoto
    Research Laboratories, Nippon Chemiphar Co, Ltd, Saitama 341 0005
    Cancer Sci 94:22-5. 2003
    ..In total, Cox-2 mRNA expression was down-regulated in eight out of ten Eker RCs and cell lines, while Cox-1 mRNA expression was up-regulated in nine out of ten Eker RCs and cell lines...
  70. ncbi Cyclooxygenase-2 expression is induced in rat brain after kainate-induced seizures and promotes neuronal death in CA3 hippocampus
    Kenji Kawaguchi
    Department of Neurology, University of Pittsburgh, PA 15260, USA
    Brain Res 1050:130-7. 2005
    ..These results suggest that COX-2 activity can contribute to epileptic neuronal injury and that selective COX-2 inhibitors are neuroprotective...
  71. ncbi Profiling of eicosanoid production in the rat hippocampus during kainic acid-induced seizure: dual phase regulation and differential involvement of COX-1 and COX-2
    Keisuke Yoshikawa
    Department of Biochemistry and Molecular Biology, Faculty of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    J Biol Chem 281:14663-9. 2006
    ..The present study demonstrates a dual phase regulatory mechanism of eicosanoid production during KA-induced seizure, providing a biochemical basis for understanding the biosynthesis and roles of eicosanoids in the brain...
  72. ncbi Induction of COX-2 by acrolein in rat lung epithelial cells
    Poonam Sarkar
    College of Pharmacy and Health Sciences, Texas Southern University, Houston, TX 77004, USA
    Mol Cell Biochem 301:191-9. 2007
    ..The results of these studies offer an explanation for the mechanism of COX-2 induction by acrolein in rat lung epithelial cells...
  73. ncbi Glutamine inhibits over-expression of pro-inflammatory genes and down-regulates the nuclear factor kappaB pathway in an experimental model of colitis in the rat
    Henrique Fillmann
    Universidade Luterana do Brasil, Hospital de Clinicas Porto Alegre, Brazil
    Toxicology 236:217-26. 2007
    ....
  74. ncbi Protective effects of cyclooxygenase-2 gene inactivation against peripheral nerve dysfunction and intraepidermal nerve fiber loss in experimental diabetes
    Aaron P Kellogg
    University of Michigan, Department of Internal Medicine, 5570D MSRB II, 1150 W Medical Center Dr, Ann Arbor, MI 48109, USA
    Diabetes 56:2997-3005. 2007
    ....
  75. ncbi Roles of vasoconstrictor prostaglandins, COX-1 and -2, and AT1, AT2, and TP receptors in a rat model of early 2K,1C hypertension
    William J Welch
    Division of Nephrology and Hypertension, Georgetown University, Washington, DC 20007, USA
    Am J Physiol Heart Circ Physiol 293:H2644-9. 2007
    ..2K,1C hypertension in rats activates renin, O(2)*(-), and vasoconstrictor PGs. Hypertension is maintained by AT(1)Rs and by COX-1, but not COX-2, products that activate TPRs...
  76. doi Profiling of genetic variations in inflammation pathway genes in relation to bladder cancer predisposition
    Hushan Yang
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Clin Cancer Res 14:2236-44. 2008
    ..Compelling evidence has indicated that inflammation plays an important role in cancer development. We sought to test the hypothesis that common sequence variants in the inflammation pathway modulate bladder cancer risk...
  77. doi The anti-inflammatory effect of celecoxib does not prevent liver fibrosis in bile duct-ligated rats
    Jun Yu
    Department of Medicine, Institute of Digestive Disease, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong, China
    Liver Int 29:25-36. 2009
    ..However, data on the progression of liver fibrosis after treatment by celecoxib are not available. This study aims to elucidate the effects of celecoxib on cholestatic liver fibrosis in rats...
  78. doi Cyclooxygenase-2 gene polymorphisms in an Australian population: association of the -1195G > A promoter polymorphism with mild asthma
    J Shi
    Lung Institute of Western Australia and Centre for Asthma, Allergy and Respiratory Research, The University of Western Australia, Perth, WA, Australia
    Clin Exp Allergy 38:913-20. 2008
    ..Single nucleotide polymorphisms (SNPs) of the COX-2 gene may influence gene transcription and PG production in the asthmatic airway...
  79. doi Mangiferin inhibits cyclooxygenase-2 expression and prostaglandin E2 production in activated rat microglial cells
    Harsharan S Bhatia
    Neurochemistry Research Group, Department of Psychiatry, University of Freiburg Medical School, Hauptstrasse 5, D 79104 Freiburg, Germany
    Arch Biochem Biophys 477:253-8. 2008
    ..These data suggest that modulation of microglial activation might contribute to the mechanism of cerebral protection by mangiferin...
  80. ncbi Interaction of cyclooxygenase-2 variants and smoking in pancreatic cancer: a possible role of nucleophosmin
    Dan Zhao
    Department of Etiology and Carcinogenesis, Cancer Hospital and Institute, Chinese Academy of Medical Sciences, Beijing
    Gastroenterology 136:1659-68. 2009
    ..This study examined the functional relevance of genetic polymorphisms in the COX-2 promoter and evaluated their associations with susceptibility to pancreatic cancer...
  81. doi Polarized light microscopic analysis of bone formation after inhibition of cyclooxygenase 1 and 2
    Luciana Borges Retamoso
    Pontifical Catholic University of Parana, Curitiba, Brazil
    Anat Rec (Hoboken) 293:195-9. 2010
    ..On the third day, the C group showed better collagen organization than the PD group. Potassium diclofenac interfered in collagen maturation, reducing fibril organization in the initial phase of orthodontic movement...
  82. doi Expressions of inducible nitric oxide synthase and cyclooxygenase-2 in gastric ischemia-reperfusion: role of angiotensin II
    Burcu Gemici
    Department of Physiology, Akdeniz University, Faculty of Medicine, Antalya, Turkey
    J Surg Res 161:126-33. 2010
    ..The aim of the present study was to investigate the effect of angiotensin II on ischemia-reperfusion induced expressions of inducible NO synthase (iNOS) and cyclooxygenase-2 (COX-2) in rat stomachs exposed to ischemia-reperfusion...
  83. doi Cyclooxygenase inhibition in ventilator-induced lung injury
    Takehiro Niitsu
    Program in Physiology and Experimental Medicine, Hospital for Sick Children, Toronto, Canada
    Anesth Analg 112:143-9. 2011
    ..Adult male rats were anesthetized and randomized with or without nonselective COX inhibition (ibuprofen) and were subjected to injurious mechanical ventilation (positive end-expiratory pressure = 0; peak inspiratory pressure = 21 mm Hg)...
  84. doi Neuroprotective effect of cyclooxygenase inhibitors in ICV-STZ induced sporadic Alzheimer's disease in rats
    Dinesh Kumar Dhull
    Neuropharmacology Division, Department of Pharmacology, ISF College of Pharmacy, Moga, Punjab, India
    J Mol Neurosci 46:223-35. 2012
    ..In summary, we demonstrate for the first time that both cyclooxygenase-1 and cyclooxygenase-2 isoforms, but not cyclooxygenase-3, are involved in the progression of neuronal damage in intracerebroventricular streptozotocin-treated rats...
  85. doi The gene encoding cyclooxygenase-2 is regulated by IL-1β and prostaglandins in 832/13 rat insulinoma cells
    Susan J Burke
    Department of Nutrition, University of Tennessee, Knoxville, TN 37996 1920, USA
    Cell Immunol 271:379-84. 2011
    ..part by inducing the expression of genes that produce soluble mediators of inflammation, such as cyclooxygenase-2 (COX2)...
  86. pmc Oxidative stress-dependent cyclooxygenase-2-derived prostaglandin f(2α) impairs endothelial function in renovascular hypertensive rats
    Xiao Yu Tian
    Institute of Vascular Medicine, Li Ka Shing Institute of Health Sciences, School of Biomedical Sciences, Chinese University of Hong Kong, Hong Kong SAR, China
    Antioxid Redox Signal 16:363-73. 2012
    ..The current study investigated whether oxidative stress-dependent cyclooxygenase (COX)-2-derived prostaglandin F(2α) (PGF(2α)) impairs endothelial function in renal arteries of renovascular hypertensive rats (RHR)...
  87. doi CDX2, COX2 and MUC2 expressions in Barrett's esophagus: can they be useful in determination of the dysplasia?
    Ilknur Cetinaslan Türkmen
    Department of Pathology, Istanbul Bilim University, Faculty of Medicine, Istanbul, Turkey
    Turk Patoloji Derg 28:251-8. 2012
    ..We aimed to search the immunohistochemical expression of CDX2, COX2 and MUC2 in Barrett's esophagus to detect any early evidence of intestinal metaplasia or dysplasia.
  88. ncbi Enteropathogenic e.coli sustains iodoacetamide-induced ulcerative colitis-like colitis in rats: modulation of IL-1β, IL-6, TNF-α, COX-2, and apoptosisi
    I Abdallah Hajj Hussein
    Department of Anatomy, American University Beirut, Beirut, Lebanon
    J Biol Regul Homeost Agents 26:515-26. 2012
    ..These effects increased with experiment duration. This work provides new arguments favouring the role of bacteria in IBD pathogenesis...
  89. doi Prostanoids as regulators of innate and adaptive immunity
    Takako Hirata
    Department of Pharmacology, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Adv Immunol 116:143-74. 2012
    ..Here, we review the role of prostanoids in regulating immunity, their involvement in immunopathology, and areas of insight that may lead to new therapeutic opportunities...
  90. doi Platelet-derived growth factor-D induces expression of cyclooxygenase-2 in rat mesangial cells through activation of PI3K/PKB and PKCs
    Yu Kyoung Park
    Department of Medical Genetic Engineering, School of Medicine, Keimyung University, Dalseo Gu, Daegu 704 701, Republic of Korea
    Int J Mol Med 31:447-52. 2013
    ..These findings collectively demonstrate for the first time that PDGF-D induces COX-2 by transcriptional upregulation in RMCs and the induction is largely related to PI3K/PKB and PKCs activities...
  91. doi Cyclooxygenase-2 promotes hepatocellular apoptosis by interacting with TNF-α and IL-6 in the pathogenesis of nonalcoholic steatohepatitis in rats
    Qi Cheng
    Department of Infectious Diseases, Huashan Hospital of Fudan University, 12 Middle Urumqi Road, Shanghai, 200040, China
    Dig Dis Sci 58:2895-902. 2013
    ..The aim of our study was to evaluate the effects of COX-2 on hepatocellular apoptosis and the mechanism of the action in the pathogenesis of NASH in rats...
  92. doi PGE(2) EP(3) receptor downregulates COX-2 expression in the medullary thick ascending limb induced by hypertonic NaCl
    Shoujin Hao
    Department of Pharmacology, New York Medical College, Valhalla, New York and
    Am J Physiol Renal Physiol 307:F736-46. 2014
    ..Collectively, the data suggest that local hypertonicity in the mTAL is associated with an increase in COX-2 expression concomitant with elevated EP3 receptor expression, which limits COX-2 activity in this segment of the nephron. ..
  93. doi COX-2 is involved in vascular oxidative stress and endothelial dysfunction of renal interlobar arteries from obese Zucker rats
    MERCEDES MUNOZ
    Departamento de Fisiologia, Facultad de Farmacia, Universidad Complutense, Madrid 28040, Spain
    Free Radic Biol Med 84:77-90. 2015
    ..In the present study, we assessed the specific relationships among reactive oxygen species (ROS), cyclooxygenase 2 (COX-2), and endothelial dysfunction in renal interlobar arteries from a genetic model of obesity/insulin ..
  94. doi Co-administration of α-lipoic acid and cyclosporine aggravates colon ulceration of acetic acid-induced ulcerative colitis via facilitation of NO/COX-2/miR-210 cascade
    Hanan M El-Gowelli
    Department of Pharmacology and Toxicology, Faculty of Pharmacy, Alexandria University, Egypt Electronic address
    Toxicol Appl Pharmacol 288:300-12. 2015
    ..Collectively, the present work highlights the probable risk of using α-lipoic acid/cyclosporine combination in ulcerative colitis patients...
  95. doi Low-salt diet increases NO bioavailability and COX-2 vasoconstrictor prostanoid production in spontaneously hypertensive rats
    T C Travaglia
    Department of Physiological Sciences, Federal University of Espirito Santo, Vitoria, ES, Brazil
    Life Sci 145:66-73. 2016
    ..The aim of this study was to observe the effects of a long period of salt restriction on the vascular reactivity of mesenteric resistance arteries of SHRs...
  96. ncbi Cloning and characterization of a growth factor-inducible cyclooxygenase gene from rat intestinal epithelial cells
    R N DuBois
    Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee
    Am J Physiol 266:G822-7. 1994
    ..In summary, we have cloned a mitogen-inducible cyclooxygenase gene from rat intestinal cells that is induced following growth factor stimulation...
  97. pmc Enhanced expression of cyclo-oxygenase isoenzyme 2 (COX-2) in asthmatic airways and its cellular distribution in aspirin-sensitive asthma
    A R Sousa
    Department of Allergy and Respiratory Medicine, UMDS, Guy s Hospital, London, UK
    Thorax 52:940-5. 1997
    ..The metabolites derived from COX-1 are probably involved in cellular housekeeping functions. COX-2 is expressed only following cellular activation by inflammatory stimuli and is thought to be involved in inflammation...
  98. ncbi [Changes of the mRNA expression and the intestinal mucosal cyclooxygenase activity in scalded rats]
    Desheng Meng
    Institute of Burn Research, Southwestern Hospital, Third Military Medical University, Chongqing, 400038 P R China
    Zhonghua Shao Shang Za Zhi 18:210-2. 2002
    ..To investigate the changes of the mRNA expression and the intestinal mucosal cyclooxygenase (COXs) activity in scalded rats...
  99. ncbi Nuclear factor-kappaB-regulated cyclooxygenase-2 expression in surgery-associated paraspinal muscle injury in rats
    Kang Lu
    Department of Neurosurgery, Chang Gung Memorial Hospital, Kaohsiung Medical Center, Chang Gung University, Kaohsiung, Taiwan
    J Neurosurg 98:181-7. 2003
    ..The roles of cyclooxygenase (COX)-2 and nuclear factor (NF)-kappaB in the inflammatory processes after retraction remain to be clarified...
  100. ncbi Expression of cyclooxygenase-2 in embryonic and fetal tissues during organogenesis and late pregnancy
    K M Stanfield
    Searle Pharmacia Corp, Skokie, Illinois, USA
    Birth Defects Res A Clin Mol Teratol 67:54-8. 2003
    ..Although the COX-2 knockout mice did not exhibit any abnormalities at birth, relatively little information exists with regard to the expression of COX-2 in the fetus during development...
  101. ncbi Role of COX-1 and -2 in prostanoid generation and modulation of angiotensin II responses
    Syed R Baber
    Department of Pharmacology, Tulane University Health Sciences Center, 1430 Tulane Ave, New Orleans, LA 70112, USA
    Am J Physiol Heart Circ Physiol 285:H2399-410. 2003
    ....

Research Grants7

  1. Peptidergic Neurotransmission in the Spinal Cord
    VIRGINIA SEYBOLD; Fiscal Year: 2009
    ..If the hypothesis is proven to be true, the data will provide evidence for a new therapeutic strategy that may be effective in treating peripheral inflammatory diseases. ..
  2. PLASTICITY OF LUT INTERNEURONS FOLLOWING SPINAL CORD INJ
    MARGARET VIZZARD; Fiscal Year: 2004
    ....
  3. Rho-Dependent COX-2 Expression in Intestinal Cells
    Lee Slice; Fiscal Year: 2007
    ..3) Define the role of Rho and of Protein Kinases acting upstream and downstream of Rho in COX-2 expression in intestinal epithelial cells. 4) Characterize COX-2 promoter elements that are responsive to Rho. ..
  4. Neurotrophic Mechanisms in LUT Plasticity with Cystitis
    MARGARET VIZZARD; Fiscal Year: 2007
    ..3). To evaluate the physiological roles of PACAP and neurotrophins in the micturition reflex pathway using PACAP knockout mice. ..
  5. LEUKOCYTE ADHESION IN COPPER DEFICIENT MICROCIRCULATION
    Dale Schuschke; Fiscal Year: 2008
    ..These experiments have particular relevance since analysis of typical Western diets suggest that 1/3 to 1/2 of those diets may provide less than the RDA of 900mg Cu/day. ..
  6. Developmental plasticity of micturation reflexes
    MARGARET VIZZARD; Fiscal Year: 2008
    ..abstract_text> ..
  7. COX2-Regulated Testosterone Biosynthesis in Male Aging
    XingJia Wang; Fiscal Year: 2009
    ..Recent studies suggested that cyclooxygenase-2 (COX2) produces a tonic inhibition of StAR gene expression...