Plaur

Summary

Gene Symbol: Plaur
Description: plasminogen activator, urokinase receptor
Alias: Par, Plaur3, uPAR, uPAR-2, uPAR-3, urokinase plasminogen activator surface receptor, U-PAR, plasminogen activator urokinase receptor 3, urinary plasminogen activator receptor 2, urinary plasminogen activator receptor 3, urokinase plasminogen activator receptor
Species: rat

Top Publications

  1. doi Predicting mortality in patients with systemic inflammatory response syndrome: an evaluation of two prognostic models, two soluble receptors, and a macrophage migration inhibitory factor
    K Kofoed
    Clinical Research Centre and Department of Infectious Diseases, Copenhagen University Hospital, Hvidovre, Kettegaard Alle 30, 2650 Hvidovre, Denmark
    Eur J Clin Microbiol Infect Dis 27:375-83. 2008
  2. doi Plasma level of soluble urokinase-type plasminogen activator receptor as a predictor of disease severity and case fatality in patients with bacteraemia: a prospective cohort study
    R Huttunen
    Department of Internal Medicine, Tampere University Hospital, University of Tampere Medical School, University of Tampere, Tampere, Finland
    J Intern Med 270:32-40. 2011
  3. doi Can early myocardial infarction-related deaths be diagnosed using postmortem urotensin receptor expression levels?
    Mustafa Talip Sener
    Department of Forensic Medicine, Ataturk University School of Medicine, 25240, Erzurum, Turkey
    Forensic Sci Med Pathol 10:395-400. 2014
  4. doi Rapamycin promotes podocyte migration through the up-regulation of urokinase receptor
    M J Wu
    Division of Nephrology, Taichung Veterans General Hospital, Taiwan School of Medicine, Chung Shan Medical University, Taiwan Graduate Institute of Clinical Medical Science, School of Medicine, China Medical University, Taiwan Institute of Biomedical Science, National Chung Hsing University, Taiwan Department of Life Science, Tunghai University, Taiwan Electronic address
    Transplant Proc 46:1226-8. 2014
  5. doi Circulating soluble urokinase plasminogen activator is elevated in patients with chronic liver disease, discriminates stage and aetiology of cirrhosis and predicts prognosis
    Henning W Zimmermann
    Department of Medicine, RWTH University Hospital Aachen, Aachen, Germany
    Liver Int 32:500-9. 2012
  6. doi Immune parameters as markers of tuberculosis extent of disease and early prediction of anti-tuberculosis chemotherapy response
    Joel Fleury Djoba Siawaya
    Department of Biomedical Sciences, Division of Molecular Biology and Human Genetics, Faculty of Health Sciences, Stellenbosch University, Cape Town, Western Cape, 7505 South Africa
    J Infect 56:340-7. 2008
  7. ncbi [Effect of amiloride on the pathology of a rat model of chronic obstructive pulmonary disease]
    Xiu di Han
    Department of Respiratory Medicine, Qilu Hospital of Shandong University, Jinan 250012, China
    Zhonghua Jie He He Hu Xi Za Zhi 30:363-7. 2007
  8. pmc Microglia and the urokinase plasminogen activator receptor/uPA system in innate brain inflammation
    Orla Cunningham
    FIRC Institute of Molecular Oncology, 20139 Milan, Italy
    Glia 57:1802-14. 2009
  9. ncbi Toxoplasma gondii pneumonitis in patients infected with the human immunodeficiency virus
    L M Schnapp
    Medical Service, San Francisco General Hospital Medical Center, University of California 94110
    Arch Intern Med 152:1073-7. 1992
  10. doi Blood chemistry markers for evaluation of inflammatory activity in Crohn's disease during infliximab therapy
    Maria H Lönnkvist
    Department of Medicine, Gastroenterology and Hepatology Unit, Karolinska University Hospital Solna, Sweden
    Scand J Gastroenterol 46:420-7. 2011

Scientific Experts

Detail Information

Publications48

  1. doi Predicting mortality in patients with systemic inflammatory response syndrome: an evaluation of two prognostic models, two soluble receptors, and a macrophage migration inhibitory factor
    K Kofoed
    Clinical Research Centre and Department of Infectious Diseases, Copenhagen University Hospital, Hvidovre, Kettegaard Alle 30, 2650 Hvidovre, Denmark
    Eur J Clin Microbiol Infect Dis 27:375-83. 2008
    ....
  2. doi Plasma level of soluble urokinase-type plasminogen activator receptor as a predictor of disease severity and case fatality in patients with bacteraemia: a prospective cohort study
    R Huttunen
    Department of Internal Medicine, Tampere University Hospital, University of Tampere Medical School, University of Tampere, Tampere, Finland
    J Intern Med 270:32-40. 2011
    Urokinase-type plasminogen activator receptor (uPAR) is expressed on a variety of different immune cells and vascular endothelial cells during inflammation...
  3. doi Can early myocardial infarction-related deaths be diagnosed using postmortem urotensin receptor expression levels?
    Mustafa Talip Sener
    Department of Forensic Medicine, Ataturk University School of Medicine, 25240, Erzurum, Turkey
    Forensic Sci Med Pathol 10:395-400. 2014
    ..In this study, changes in the level of the mRNA for the urotensin receptor (UR) were investigated postmortem to determine the suitability of UR as a biomarker for diagnosis of early MI after death...
  4. doi Rapamycin promotes podocyte migration through the up-regulation of urokinase receptor
    M J Wu
    Division of Nephrology, Taichung Veterans General Hospital, Taiwan School of Medicine, Chung Shan Medical University, Taiwan Graduate Institute of Clinical Medical Science, School of Medicine, China Medical University, Taiwan Institute of Biomedical Science, National Chung Hsing University, Taiwan Department of Life Science, Tunghai University, Taiwan Electronic address
    Transplant Proc 46:1226-8. 2014
    ..However, induction of urokinase receptor (uPAR) signaling in podocytes leads to foot process effacement and urinary protein...
  5. doi Circulating soluble urokinase plasminogen activator is elevated in patients with chronic liver disease, discriminates stage and aetiology of cirrhosis and predicts prognosis
    Henning W Zimmermann
    Department of Medicine, RWTH University Hospital Aachen, Aachen, Germany
    Liver Int 32:500-9. 2012
    ..Interactions between urokinase plasminogen activator (uPA) and its receptor (uPAR) have been functionally linked to hepatic inflammation and fibrosis in mice...
  6. doi Immune parameters as markers of tuberculosis extent of disease and early prediction of anti-tuberculosis chemotherapy response
    Joel Fleury Djoba Siawaya
    Department of Biomedical Sciences, Division of Molecular Biology and Human Genetics, Faculty of Health Sciences, Stellenbosch University, Cape Town, Western Cape, 7505 South Africa
    J Infect 56:340-7. 2008
    ..C-reactive protein (CRP), soluble intercellular adhesion molecule-1 (sICAM-1), soluble urokinase plasminogen activator receptor (suPAR), soluble lymphocyte activation gene-3 (sLAG-3), granzyme B, soluble tumour necrosis ..
  7. ncbi [Effect of amiloride on the pathology of a rat model of chronic obstructive pulmonary disease]
    Xiu di Han
    Department of Respiratory Medicine, Qilu Hospital of Shandong University, Jinan 250012, China
    Zhonghua Jie He He Hu Xi Za Zhi 30:363-7. 2007
    ....
  8. pmc Microglia and the urokinase plasminogen activator receptor/uPA system in innate brain inflammation
    Orla Cunningham
    FIRC Institute of Molecular Oncology, 20139 Milan, Italy
    Glia 57:1802-14. 2009
    The urokinase plasminogen activator (uPA) receptor (uPAR) is a GPI-linked cell surface protein that facilitates focused plasmin proteolytic activity at the cell surface...
  9. ncbi Toxoplasma gondii pneumonitis in patients infected with the human immunodeficiency virus
    L M Schnapp
    Medical Service, San Francisco General Hospital Medical Center, University of California 94110
    Arch Intern Med 152:1073-7. 1992
    ..Toxoplasma gondii must be considered a potential cause of pulmonary disease during the evaluation of human immunodeficiency virus-infected patients with respiratory symptoms...
  10. doi Blood chemistry markers for evaluation of inflammatory activity in Crohn's disease during infliximab therapy
    Maria H Lönnkvist
    Department of Medicine, Gastroenterology and Hepatology Unit, Karolinska University Hospital Solna, Sweden
    Scand J Gastroenterol 46:420-7. 2011
    ..markers (high sensitive C-reactive protein [hs-CRP], calprotectin, total nitrite, soluble urokinase Plasminogen Activator Receptor [suPAR], ghrelin and endothelin) are investigated to study inflammatory activity and correlation ..
  11. doi Soluble urokinase plasminogen activator receptor in plasma is associated with incidence of CVD. Results from the Malmö Diet and Cancer Study
    M Persson
    Department of Clinical Sciences Medicine, Malmo, Lund University, Sweden
    Atherosclerosis 220:502-5. 2012
    Soluble urokinase plasminogen activator receptor (suPAR) is a highly sensitive marker that reflects increased inflammation and is positively correlated with pro-inflammatory biomarkers...
  12. pmc Urokinase-type plasminogen activator receptor (uPAR)-mediated regulation of WNT/β-catenin signaling is enhanced in irradiated medulloblastoma cells
    Swapna Asuthkar
    Departments of Cancer Biology and Pharmacology, University of Illinois College of Medicine at Peoria, Peoria, Illinois 61605, USA
    J Biol Chem 287:20576-89. 2012
    b>Urokinase plasminogen activator receptor (uPAR) is known to promote invasion, migration, and metastasis in cancer cells...
  13. ncbi Soluble urokinase plasminogen activator receptor as a useful biomarker to predict the response to adalimumab in patients with rheumatoid arthritis in a Japanese population
    Tomohiro Koga
    Unit of Translational Medicine, Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
    Clin Exp Rheumatol 29:811-5. 2011
    To determine whether soluble urokinase plasminogen activator receptor is a useful biomarker to predict the response to adalimumab (ADA) in Japanese patients with rheumatoid arthritis.
  14. doi The immune marker soluble urokinase plasminogen activator receptor is associated with new-onset diabetes in non-smoking women and men
    S B Haugaard
    Clinical Research Centre, Copenhagen University, Denmark
    Diabet Med 29:479-87. 2012
    To explore the putative association of new-onset diabetes and the soluble urokinase plasminogen activator receptor (suPAR), which is a new and stable plasma marker of immune function and low-grade inflammation...
  15. pmc Urokinase plasminogen activator receptor-deficient mice demonstrate reduced hyperoxia-induced lung injury
    Marieke A D van Zoelen
    Center for Experimental and Molecular Medicine CEMM, G2 130, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam
    Am J Pathol 174:2182-9. 2009
    ..Hyperoxia-induced lung injury is characterized by neutrophil infiltration into the lungs. The urokinase plasminogen activator receptor (uPAR) has been deemed important for leukocyte trafficking...
  16. ncbi Urokinase plasminogen activator, uPAR, MMP-2, and MMP-9 in the C6-glioblastoma rat model
    Patrick J Schuler
    Department of Otorhinolaryngology, University of Duisburg Essen, Hufelandstr 55, 45147 Essen, Germany
    In Vivo 26:571-6. 2012
    ..In glioblastoma multiforme (GBM), the serine protease urokinase plasminogen activator (uPA), and matrix metalloproteases (MMP-2/MMP-9) contribute to its invasive growth pattern, which is the major obstacle to successful surgical treatment...
  17. doi Hyperfibrinolysis, uPA/suPAR system, kynurenines, and the prevalence of cardiovascular disease in patients with chronic renal failure on conservative treatment
    Krystyna Pawlak
    Department of Monitored Pharmacotherapy, Medical University, Bialystok, Poland
    Am J Med Sci 339:5-9. 2010
    ..However, no data are yet available on the associations between these 2 systems in relation to CVD prevalence in patients with chronic renal failure (CRF)...
  18. ncbi Renal urokinase-type plasminogen activator (uPA) receptor but not uPA deficiency strongly attenuates ischemia reperfusion injury and acute kidney allograft rejection
    Faikah Gueler
    Department of Nephrology, Medical School Hannover, Hannover, Germany
    J Immunol 181:1179-89. 2008
    ..processes highly regulated by the urokinase-type plasminogen activator (uPA) and its specific receptor (uPAR). Recently, up-regulation of uPA and uPAR has been shown to correlate with allograft rejection in human biopsies...
  19. pmc Differential roles of uPAR in peritoneal ovarian carcinomatosis
    Nada N Al-Hassan
    Department of Urology, University of Virginia School of Medicine, Charlottesville, VA 22908, USA
    Neoplasia 14:259-70. 2012
    ..b>Urokinase plasminogen activator receptor (uPAR) is a multifunctional receptor involved in a myriad of tumor cell processes...
  20. pmc The Prognostic Value of suPAR Compared to Other Inflammatory Markers in Patients with Severe Sepsis
    Anna Gustafsson
    Department of Biomedical Science, Malmo University, Malmo, Sweden
    Biomark Insights 7:39-44. 2012
    ..The weak correlation between suPAR and other inflammatory markers might suggest that suPAR reflects general activation of the immune system rather than exerting inflammatory actions...
  21. doi Elevated soluble urokinase receptor values in CSF, age and bacterial meningitis infection are independent and additive risk factors of fatal outcome
    G Tzanakaki
    National Meningitis Reference Laboratory, National School of Public Health, 196, Alexandras Avenue, Athens, Greece
    Eur J Clin Microbiol Infect Dis 31:1157-62. 2012
    ..7, 95% CI 10.6-690.2) with both sensitivity and specificity being equal to the value of 0.9. In conclusion, suPAR, age and type of infection have an additive effect in predicting mortality among patients suspected of meningitis...
  22. doi Soluble urokinase plasminogen activator receptor (suPAR) levels in healthy pregnancy and preeclampsia
    Gergely Toldi
    First Department of Pediatrics, Semmelweis University, Budapest, Hungary
    Clin Chem Lab Med 49:1873-6. 2011
    ..Soluble urokinase plasminogen activator receptor (suPAR) is a biomarker increasingly used for the monitoring of systemic inflammation...
  23. doi The expression of fibrinolytic components in chronic paranasal sinus disease
    Takayuki Sejima
    Upper Airway Research Laboratory, Department of Otorhinolaryngology, Ghent University Hospital, Ghent, Belgium
    Am J Rhinol Allergy 25:1-6. 2011
    ..To clarify the relationship between these components and the pathology of CRS, we analyzed fibrinolytic components in sinonasal mucosa of CRS...
  24. pmc Plasminogen activator promotes recovery following spinal cord injury
    NICHOLAS SEEDS
    Department of Biochemistry and Molecular Genetics, and Neuroscience Program, University of Colorado School of Medicine, Aurora, CO 80045, USA
    Cell Mol Neurobiol 31:961-7. 2011
    ..As shown here uPA acts in a cell signaling manner via binding to its receptor uPAR rather than as a protease, since uPAR knockout mice or knock-in mice possessing a modified uPA that is unable to ..
  25. doi Soluble urokinase plasminogen activator receptor (suPAR) is associated with metabolic changes in HIV-1-infected Africans: a prospective study
    Carla M T Fourie
    Hypertension in Africa Research Team HART, School for Physiology, Nutrition and Consumer Sciences, North West University Potchefstroom Campus, Private Bag X6001, Potchefstroom, 2520, South Africa
    Inflammation 35:221-9. 2012
    Soluble urokinase plasminogen activator receptor (suPAR) is associated with inflammation and may predict lipodystrophy and dysmetabolism in human immunodeficiency virus (HIV)-infected individuals on antiretroviral therapy...
  26. doi Urokinase plasminogen activator receptor in adipose tissue macrophages of morbidly obese subjects
    Raffaella Cancello
    Inserm U872, CRC Université Pierre et Marie Curie Paris 6, CHRU Pitié Salpétrière, Service de Nutrition, Paris, France
    Obes Facts 4:17-25. 2011
    ..We previously identified, by a pangenomic approach (microarrays), the urokinase plasminogen activator receptor (PLAUR or CD87) as a potential marker of subcutaneous adipose tissue macrophage infiltration (ATM)...
  27. doi In vivo fluorescence-mediated tomography for quantification of urokinase receptor-dependent leukocyte trafficking in inflammation
    Jan Larmann
    Department of Anesthesiology and Intensive Care Medicine, Hannover Medical School, Hannover, Germany
    Anesthesiology 113:610-8. 2010
    ..Leukocyte recruitment critically depends on the urokinase-type plasminogen activator receptor (u-PAR). We here use a novel technique to longitudinally quantify cell trafficking in inflammatory models in live animals.
  28. doi Urokinase receptor is necessary for bacterial defense against pneumonia-derived septic melioidosis by facilitating phagocytosis
    W Joost Wiersinga
    Center for Infection and Immunity Amsterdam, University of Amsterdam, Amsterdam, The Netherlands
    J Immunol 184:3079-86. 2010
    Urokinase receptor (urokinase-type plasminogen activator receptor [uPAR], CD87), a GPI-anchored protein, is considered to play an important role in inflammation and fibrinolysis...
  29. doi Urine suPAR levels compared with plasma suPAR levels as predictors of post-consultation mortality risk among individuals assumed to be TB-negative: a prospective cohort study
    Paulo Rabna
    Bandim Health Project, INDEPTH Network, Apartado 861, Bissau Codex, Guinea Bissau
    Inflammation 33:374-80. 2010
    ..75. For HIV-negative individuals, little or no prognostic effect was observed. However, in both HIV positives and negatives, the predictive effect of U-suPAR was found to be inferior to that of P-suPAR...
  30. doi Initial brain lesion size affects the extent of subsequent pathophysiological responses
    Nobuo Nagai
    Department of Physiology, Kinki University School of Medicine, Japan
    Brain Res 1322:109-17. 2010
    ..Furthermore, we found that, smaller lesions in mice lacking gene of urokinase-receptor (uPAR(-/-)) than wild type (uPAR(+/+)) mice on day 3 showed less reduction until day 7 in MCA-O model, whereas lesions ..
  31. doi Evaluation of plasma urokinase-type plasminogen activator and urokinase-type plasminogen-activator receptor in patients with acute and chronic hepatitis B
    Huanqin Zhou
    Department of Clinical Laboratory, Zhejiang Hospital, Hangzhou 310013, China
    Thromb Res 123:537-42. 2009
    Urokinase-type plasminogen activator (uPA) and urokinase-type plasminogen activator receptor (uPAR) are known to be important factors in the pathogenesis of tumors and certain non-viral inflammatory diseases...
  32. pmc The urokinase receptor (uPAR) facilitates clearance of Borrelia burgdorferi
    Joppe W R Hovius
    Center for Experimental and Molecular Medicine CEMM, Academic Medical Center, University of Amsterdam, AMC, Amsterdam, The Netherlands
    PLoS Pathog 5:e1000447. 2009
    ..borreliosis, the spirochete Borrelia burgdorferi, has been shown to induce expression of the urokinase receptor (uPAR); however, the role of uPAR in the immune response against Borrelia has never been investigated...
  33. ncbi The receptor for the plasminogen activator of urokinase type is up-regulated in transformed rat thyroid cells
    P Ragno
    Centro di Endocrinologia ed Oncologia Sperimentale, Consiglio Nazionale delle Ricerche, Naples, Italy
    FEBS Lett 306:193-8. 1992
    ..membrane-bound uPA by treating the cells with phosphatidylinositol-specific phospholipase C, suggesting that rat uPAR, like its human counterpart, is linked to the membrane by a glucosyl-phosphatidylinositol anchor...
  34. ncbi Isolation and characterization of multiple isoforms of the rat urokinase receptor in osteoblasts
    S A Rabbani
    Department of Medicine, McGill University, Montreal, Quebec, Canada
    FEBS Lett 338:69-74. 1994
    A rat urokinase receptor (uPAR) cDNA fragment was amplified by RT-PCR from RNA of the rat osteoblastic cell line CFK-1. Using this DNA species as a hybridization probe two rat uPAR cDNAs were isolated from a CFK-1 cDNA library...
  35. ncbi The potential molecular mechanism of overexpression of uPA, IL-8, MMP-7 and MMP-9 induced by TRAIL in pancreatic cancer cell
    Dong Hui Zhou
    Department of Oncology, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
    Hepatobiliary Pancreat Dis Int 7:201-9. 2008
    ..The purpose of this study was to find out if TRAIL could induce the expression of uPA, IL-8, MMP-7 and MMP-9.and to explore the corresponding potential signaling transduction pathway in pancreatic cancer cells...
  36. ncbi Urokinase plasminogen activator amino-terminal peptides inhibit development of the rat ventral prostate
    F Elfman
    Department of Anatomy, University of California, San Francisco 94143, USA
    Differentiation 69:108-20. 2001
    The plasma membrane urokinase plasminogen activator receptor (uPAR) localizes and enhances activation of pro-uPA. Active uPA, in turn, promotes increased degradation of the extracellular matrix (ECM) by activation of plasminogen...
  37. pmc Expression pattern of the urokinase-plasminogen activator system in rat DS-sarcoma: role of oxygenation status and tumour size
    M Weinmann
    Institute of Physiology and Pathophysiology, University of Mainz, 55099 Mainz, Germany
    Br J Cancer 86:1355-61. 2002
    ..This may indicate that the serum level of plasminogen activator inhibitor type 1 is not a reliable surrogate marker of tumour hypoxia...
  38. ncbi Decreased expression of intercellular adhesion molecule-1 (ICAM-1) and urokinase-type plasminogen activator receptor (uPAR) is associated with tumor cell spreading in vivo
    Ana C Donadio
    Departamento de Bioquimica Clinica, Facultad de Ciencias Quimicas, Universidad Nacional de Cordoba, Ciudad Universitaria, Pabellón Argentina ala I subsuelo, CP 5000, Cordoba, Argentina
    Clin Exp Metastasis 19:437-44. 2002
    ..1 +/- 8.7%) and urokinase-type plaminogen activator receptor (uPAR, 51.2 +/- 5.2%) positive cells, while a weak expression of MHC class II (IA, 2.2 +/- 0.2% and IE, 17.4 +/- 3...
  39. ncbi Urokinase receptor surface expression regulates monocyte adhesion in acute myocardial infarction
    Andreas E May
    Medizinische Klinik des Klinikums Rechts der Isar und Deutsches Herzzentrum, Technische Universitat Munchen, Munich, Germany
    Blood 100:3611-7. 2002
    The urokinase receptor (urokinase plasminogen activator receptor; uPAR) regulates monocyte adhesion by direct binding to vitronectin and by forming complexes with integrins...
  40. ncbi Expression of urokinase-type plasminogen activator and its receptor is up-regulated during tendon healing
    Wei Xia
    Orthopaedic Research Institute, The St George Hospital, University of New South Wales, Kogarah, Sydney, NSW 2217, Australia
    J Orthop Res 21:819-25. 2003
    ..We used a rat Achilles tendon model to study mRNA and protein expression of uPA and its receptor (uPAR) during tendon healing using immunohistochemical, Northern and Western blot analyses...
  41. ncbi Gene expression changes of urokinase plasminogen activator and urokinase receptor in rat testes at postnatal stages
    Dong hui Huang
    Family Planning Research Institute, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
    Asian J Androl 9:679-83. 2007
    To investigate the gene expression changes of urokinase plasminogen activator (uPA)/urokinase receptor (uPAR) in rat testes at postnatal stages and explore the effects of uPA/uPAR system on the rat spermatogenesis.
  42. ncbi Domain 2 of the urokinase receptor contains an integrin-interacting epitope with intrinsic signaling activity: generation of a new integrin inhibitor
    Bernard Degryse
    Department of Molecular Biology and Functional Genomics, DIBIT, Universita Vita Salute San Raffaele, Via Olgettina 58, 20132 Milan, Italy
    J Biol Chem 280:24792-803. 2005
    We investigated the interaction between the urokinase receptor (uPAR) and the integrin alphavbeta3. Vitronectin (VN) induces cell migration by binding to alphavbeta3, but expression of the uPAR boosts its efficacy...
  43. doi Expression of urokinase-type plasminogen activator receptor is increased during epileptogenesis in the rat hippocampus
    L Lahtinen
    Epilepsy Research Laboratory, A I Virtanen Institute for Molecular Sciences, University of Kuopio, PO Box 1627, FIN 70211 Kuopio, Finland
    Neuroscience 163:316-28. 2009
    Urokinase-type plasminogen activator receptor (uPAR) is functionally a pleiotropic mediator involved in cell adhesion, proliferation, differentiation and migration as well as in matrix degradation, apoptosis, and angiogenesis in cancer ..
  44. ncbi Renal synthesis of urokinase type-plasminogen activator, its receptor, and plasminogen activator inhibitor-1 in diabetic nephropathy in rats: modulation by angiotensin-converting-enzyme inhibitor
    Miyazaki Kenichi
    The Department of Histology and Cell Biology, Nagasaki University School of Medicine, Nagasaki, Japan
    J Lab Clin Med 144:69-77. 2004
    ..of plasminogen-activator inhibitor-1 (PAI-1), urokinase-type plasminogen activator (uPA), and uPA receptor (uPAR), as well as the relevance of such expression to the production of type IV collagen, a major component of ..
  45. ncbi Clinical significance of urokinase-type plasminogen activator receptor (uPAR) expression in cancer
    Charles Edo de Bock
    Orthopaedic Research Institute, St George Hospital, University of New South Wales, Kogarah, Sydney, NSW 2217, Australia
    Med Res Rev 24:13-39. 2004
    ..The molecular role of the uPA receptor (uPAR) is well characterized with its participation in cell migration and extracellular matrix (ECM) degradation...
  46. ncbi Pericellular proteolysis by leukocytes and tumor cells on substrates: focal activation and the role of urokinase-type plasminogen activator
    Andrei L Kindzelskii
    Department of Ophthalmology and Visual Sciences and Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, Michigan 48105, USA
    Histochem Cell Biol 121:299-310. 2004
    Previous studies have shown that the urokinase-type plasminogen activator receptor (uPAR) is localized to the adherence sites of leukocytes and tumor cells suggesting that pericellular proteolysis may accompany focal activation of ..
  47. ncbi uPA, uPAR and TGFβ₁ expression during early and late post myocardial infarction period in rat myocardium
    Anastasia Stavropoulou
    Department of Experimental Physiology, Medical School, National and Kapodistrian University of Athens, 75 Micras Asias, Goudi Athens 11527, Greece
    In Vivo 24:647-52. 2010
    ..of transforming growth factor beta 1 (TGFβ₁), urokinase-type plasminogen activator (uPA) and uPA receptor (uPAR) were analysed after artery ligation-induced myocardial infarction (MI) in the rat myocardium...
  48. ncbi Messenger RNA profiles in liver injury and stress: a comparison of lethal and nonlethal rat models
    Niels Tygstrup
    Liver Unit, Laboratory of Hepatology, Rigshospitalet 2151, 9 Blegdamsvej, DK 2100 Copenhagen, Denmark
    Biochem Biophys Res Commun 290:518-25. 2002
    ..Simultaneously, the processes required for the integrity of its own structure and function are maintained as a result of regulated expression of the genes that produce the proteins needed to perform both set of functions...