Pitx3

Summary

Gene Symbol: Pitx3
Description: paired-like homeodomain 3
Alias: pituitary homeobox 3, homeobox protein PITX3, homeobox protein PTX3, paired-like homeodomain transcription factor 3
Species: rat

Top Publications

  1. ncbi A novel homeobox gene PITX3 is mutated in families with autosomal-dominant cataracts and ASMD
    E V Semina
    Department of Pediatrics, The University of Iowa, Iowa City 52242 1083, USA
    Nat Genet 19:167-70. 1998
  2. ncbi A response element for the homeodomain transcription factor Ptx3 in the tyrosine hydroxylase gene promoter
    P Cazorla
    Department of Medical Pharmacology, Rudolf Magnus Institute for Neurosciences, Medical Faculty, Utrecht University, The Netherlands
    J Neurochem 74:1829-37. 2000
  3. ncbi A double-deletion mutation in the Pitx3 gene causes arrested lens development in aphakia mice
    D K Rieger
    Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, Massachusetts, 02115, USA
    Genomics 72:61-72. 2001
  4. pmc Posterior polar cataract is the predominant consequence of a recurrent mutation in the PITX3 gene
    P K F Addison
    Department of Molecular Genetics, Institute of Ophthalmology, London, UK
    Br J Ophthalmol 89:138-41. 2005
  5. doi Effects on differentiation of embryonic ventral midbrain progenitors by Lmx1a, Msx1, Ngn2, and Pitx3
    Laurent Roybon
    Neuronal Survival Unit, Department of Experimental Medical Science, 221 84 Lund, Sweden
    J Neurosci 28:3644-56. 2008
  6. pmc Expression of truncated PITX3 in the developing lens leads to microphthalmia and aphakia in mice
    Kenta Wada
    Department of Bioproduction, Tokyo University of Agriculture, Abashiri, Japan Mammalian Genetics Project, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan
    PLoS ONE 9:e111432. 2014
  7. pmc Morphine administration modulates expression of Argonaute 2 and dopamine-related transcription factors involved in midbrain dopaminergic neurons function
    D García-Pérez
    Group of Cellular and Molecular Pharmacology, Faculty of Medicine, University of Murcia, Murcia, Spain
    Br J Pharmacol 168:1889-901. 2013
  8. doi Signaling of glial cell line-derived neurotrophic factor and its receptor GFRα1 induce Nurr1 and Pitx3 to promote survival of grafted midbrain-derived neural stem cells in a rat model of Parkinson disease
    Zhinian Lei
    Department of Human Anatomy and Histoembryology, Medical School, Southeast University, Nanjing, PR China
    J Neuropathol Exp Neurol 70:736-47. 2011
  9. pmc Chronic methamphetamine administration causes differential regulation of transcription factors in the rat midbrain
    Irina N Krasnova
    Molecular Neuropsychiatry Research Branch, DHHS NIH NIDA Intramural Research Program, Bethesda, Maryland, United States of America
    PLoS ONE 6:e19179. 2011
  10. doi Ontogenetic expression of dopamine-related transcription factors and tyrosine hydroxylase in prenatally stressed rats
    Maria R Katunar
    Instituto de Química y Fisicoquímica Biológicas UBA CONICET, Facultad de Farmacia y Bioquimica, Universidad de Buenos Aires, Junin 956, C1113AAD, Buenos Aires, Argentina
    Neurotox Res 18:69-81. 2010

Scientific Experts

  • Laurent Roybon
  • Kim M Summers
  • Tatiana M Korotkova
  • Maria R Katunar
  • Kenta Wada
  • D García-Pérez
  • Zhinian Lei
  • Irina N Krasnova
  • Constantine James Konstantoulas
  • Alicia Brusco
  • Trinidad Saez
  • Marta C Antonelli
  • Dehua Yang
  • Paul Ardayfio
  • D Leo
  • Carla Bidinost
  • P K F Addison
  • Tomoki Tada
  • Yoshiaki Kikkawa
  • Junichi Saitou
  • Gou Takahashi
  • Midori Shimanuki
  • Yoshibumi Matsushima
  • Sari Suzuki
  • Yasuhiro Yoshizawa
  • Hiroshi Hiai
  • M P Smidt
  • Sayaka Hasegawa
  • Kei Watanabe
  • Naoki Yamamoto
  • Masumi Ichikawa
  • Yo Obara
  • F Sáez-Belmonte
  • M V Milanes
  • C Nunez
  • M L Laorden
  • D K Rieger
  • Jean Lud Cadet
  • Shuilin Zeng
  • Yu Jiang
  • Amber B Hodges
  • Bruce Ladenheim
  • Tao Li
  • Nora D Volkow
  • Jianbao Zhu
  • P Cazorla
  • Meng Li
  • Malin Parmar
  • Changgeng Peng
  • Ming Ming
  • Jisook Moon
  • Xuping Li
  • Dong Youn-Hwang
  • Liang Li
  • Sheng Chen
  • Kwang Soo Kim
  • Weidong Le
  • Xiaolan Fan
  • Ka Ka Amanda Leung
  • F Fumagalli
  • C Perrone-Capano
  • M A Riva
  • G Racagni
  • U di Porzio
  • J P Burbach
  • Daniel Chung
  • Andre Megarbane
  • David W Stockton
  • Elias I Traboulsi
  • Antoine Khoury
  • Masayuki Matsumoto
  • Bassem A Bejjani
  • Nabiha Salem
  • E V Semina
  • Kang Zhang
  • V Berry
  • P J Francis
  • A T Moore
  • S S Bhattacharya
  • A C W Ionides
  • W McLean
  • A Sidow
  • E Reichenberger
  • B R Olsen
  • K L O'Malley
  • P Bitoun
  • W L Alward
  • C Funkhauser
  • R E Ferrell
  • J C Murray

Detail Information

Publications19

  1. ncbi A novel homeobox gene PITX3 is mutated in families with autosomal-dominant cataracts and ASMD
    E V Semina
    Department of Pediatrics, The University of Iowa, Iowa City 52242 1083, USA
    Nat Genet 19:167-70. 1998
    We report here the identification of a new human homeobox gene, PITX3, and its involvement in anterior segment mesenchymal dysgenesis (ASMD) and congenital cataracts in humans...
  2. ncbi A response element for the homeodomain transcription factor Ptx3 in the tyrosine hydroxylase gene promoter
    P Cazorla
    Department of Medical Pharmacology, Rudolf Magnus Institute for Neurosciences, Medical Faculty, Utrecht University, The Netherlands
    J Neurochem 74:1829-37. 2000
    ..This suggests that Ptx3 contributes to the regulation of TH expression in mesencephalic dopaminergic neurons...
  3. ncbi A double-deletion mutation in the Pitx3 gene causes arrested lens development in aphakia mice
    D K Rieger
    Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, Massachusetts, 02115, USA
    Genomics 72:61-72. 2001
    ..The Pitx3 gene, known to be expressed in lens primordia, shows zero recombination with the ak mutation on our ..
  4. pmc Posterior polar cataract is the predominant consequence of a recurrent mutation in the PITX3 gene
    P K F Addison
    Department of Molecular Genetics, Institute of Ophthalmology, London, UK
    Br J Ophthalmol 89:138-41. 2005
    The authors recently identified three large genetically unrelated families with an identical 17 base pair duplication mutation in exon 4 of the PITX3 gene. Here, they report the detailed clinical phenotype.
  5. doi Effects on differentiation of embryonic ventral midbrain progenitors by Lmx1a, Msx1, Ngn2, and Pitx3
    Laurent Roybon
    Neuronal Survival Unit, Department of Experimental Medical Science, 221 84 Lund, Sweden
    J Neurosci 28:3644-56. 2008
    ..Lmx1a (LIM homeobox transcription factor 1, alpha), Msx1 (msh homeobox homolog 1), Ngn2 (neurogenin 2), or Pitx3 (paired-like homeodomain transcription factor 3) in neurospheres derived from embryonic day 14...
  6. pmc Expression of truncated PITX3 in the developing lens leads to microphthalmia and aphakia in mice
    Kenta Wada
    Department of Bioproduction, Tokyo University of Agriculture, Abashiri, Japan Mammalian Genetics Project, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan
    PLoS ONE 9:e111432. 2014
    ..the genomic region that encodes the homeodomain of the paired-like homeodomain transcription factor 3 gene (Pitx3) as the mutation responsible for the microphthalmia and aphakia...
  7. pmc Morphine administration modulates expression of Argonaute 2 and dopamine-related transcription factors involved in midbrain dopaminergic neurons function
    D García-Pérez
    Group of Cellular and Molecular Pharmacology, Faculty of Medicine, University of Murcia, Murcia, Spain
    Br J Pharmacol 168:1889-901. 2013
    ..in transcription factors that regulate the development and maintenance of dopamine (DA) neurons (such as Nurr1 and Pitx3) play an important role in the pathogenesis of addiction diseases...
  8. doi Signaling of glial cell line-derived neurotrophic factor and its receptor GFRα1 induce Nurr1 and Pitx3 to promote survival of grafted midbrain-derived neural stem cells in a rat model of Parkinson disease
    Zhinian Lei
    Department of Human Anatomy and Histoembryology, Medical School, Southeast University, Nanjing, PR China
    J Neuropathol Exp Neurol 70:736-47. 2011
    ..were used totest the expression of the orphan nuclear receptor Nurr1 and thetranscription factor Pitx3 and newborn tyrosine hydroxylase (TH)-positive cells...
  9. pmc Chronic methamphetamine administration causes differential regulation of transcription factors in the rat midbrain
    Irina N Krasnova
    Molecular Neuropsychiatry Research Branch, DHHS NIH NIDA Intramural Research Program, Bethesda, Maryland, United States of America
    PLoS ONE 6:e19179. 2011
    ..in the expression of the dopamine developmental factors, Shh, Lmx1b, and Nurr1, but not in the levels of Otx2 and Pitx3, in saline-pretreated rats...
  10. doi Ontogenetic expression of dopamine-related transcription factors and tyrosine hydroxylase in prenatally stressed rats
    Maria R Katunar
    Instituto de Química y Fisicoquímica Biológicas UBA CONICET, Facultad de Farmacia y Bioquimica, Universidad de Buenos Aires, Junin 956, C1113AAD, Buenos Aires, Argentina
    Neurotox Res 18:69-81. 2010
    ..Employing an immunocytochemical approach, we studied the expression levels of two transcription factors Nurr1 and Pitx3 which are expressed at critical moments of DA neurons differentiation as well as the expression of the rate ..
  11. pmc Anterior segment mesenchymal dysgenesis in a large Australian family is associated with the recurrent 17 bp duplication in PITX3
    Kim M Summers
    Roslin Institute, University of Edinburgh, Roslin, Midlothian, UK
    Mol Vis 14:2010-5. 2008
    A recurrent 17 bp duplication (c.657ins17bp) of a segment of the paired-like homeodomain transcription factor 3 (PITX3) gene on human chromosome 10 has been reported in seven families with autosomal dominant posterior polar cataracts ..
  12. pmc Impaired learning and memory in Pitx3 deficient aphakia mice: a genetic model for striatum-dependent cognitive symptoms in Parkinson's disease
    Paul Ardayfio
    Molecular Neurobiology Laboratory, MRC 215, 115 Mill Street, McLean Hospital, Harvard Medical School, Belmont, MA 02478, USA
    Neurobiol Dis 31:406-12. 2008
    ..Aphakia mice, which are deficient in the transcription factor Pitx3, model the selective nigrostriatal DA loss in PD...
  13. ncbi Chronic cocaine administration modulates the expression of transcription factors involved in midbrain dopaminergic neuron function
    D Leo
    Institute of Genetics and Biophysics A Buzzati Traverso, CNR, Via Pietro Castellino, 111, 80131 Naples, Italy
    Exp Neurol 203:472-80. 2007
    ..We show that chronic, but not acute or subchronic, cocaine administration downregulates Nurr1 and Pitx3 transcripts whereas En1 transcripts are upregulated...
  14. ncbi Heterozygous and homozygous mutations in PITX3 in a large Lebanese family with posterior polar cataracts and neurodevelopmental abnormalities
    Carla Bidinost
    Health Research and Education Center, Washington State University Spokane, Spokane, Washington, USA
    Invest Ophthalmol Vis Sci 47:1274-80. 2006
    The PITX3 gene, which codes for a homeobox bicoidlike transcription factor is responsible for dominant cataract and anterior segment mesenchymal dysgenesis in humans...
  15. doi Immunocytochemical expression of dopamine-related transcription factors Pitx3 and Nurr1 in prenatally stressed adult rats
    Maria R Katunar
    Instituto de Química y Fisicoquímica Biológicas UBA CONICET, Facultad de Farmacia y Bioquimica, Universidad de Buenos Aires, Buenos Aires, Argentina
    J Neurosci Res 87:1014-22. 2009
    ..Recently, two transcription factors, Nurr1 and Pitx3, have been identified that are expressed at critical moments of DA neuron differentiation...
  16. doi Pitx3-transfected astrocytes secrete brain-derived neurotrophic factor and glial cell line-derived neurotrophic factor and protect dopamine neurons in mesencephalon cultures
    Dehua Yang
    Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai Jiao Tong University School of Medicine, Shanghai, People s Republic of China
    J Neurosci Res 86:3393-400. 2008
    The transcription factor Pitx3 is crucial for the development and differentiation of dopamine (DA) neurons...
  17. doi FoxP1 promotes midbrain identity in embryonic stem cell-derived dopamine neurons by regulating Pitx3
    Constantine James Konstantoulas
    MRC Clinical Sciences Centre, Faculty of Medicine, Imperial College, London, UK
    J Neurochem 113:836-47. 2010
    ..Enforced expression of FoxP1 in embryonic stem cells actuates the expression of Pitx3, a homeobox protein that is exclusively expressed in midbrain dopaminergic neurons and is required for their ..
  18. ncbi Differential expression of the homeobox gene Pitx3 in midbrain dopaminergic neurons
    Tatiana M Korotkova
    Institute of Neurophysiology, Heinrich Heine University, Physiology II, POB 101007, Duesseldorf, Germany
    Eur J Neurosci 22:1287-93. 2005
    The transcription factor Pitx3 is expressed selectively in the midbrain and regulates the differentiation and survival of dopaminergic neurons. Lack of this factor results in a degeneration similar to that seen in Parkinson's disease...
  19. pmc A homeodomain gene Ptx3 has highly restricted brain expression in mesencephalic dopaminergic neurons
    M P Smidt
    Rudolf Magnus Institute for Neurosciences, Department of Medical Pharmacology, Medical Faculty, Utrecht University, The Netherlands
    Proc Natl Acad Sci U S A 94:13305-10. 1997
    ..Thus, Ptx3 is a unique transcription factor marking the mesDA neurons at the exclusion of other dopaminergic neurons, and it may be involved in developmental determination of this neuronal lineage...