pigment epithelium derived factor

Summary

Gene Symbol: pigment epithelium derived factor
Description: serpin family F member 1
Alias: Dmrs91, Pedf, pigment epithelium-derived factor, alpha-2 antiplasmin, serine (or cysteine) peptidase inhibitor, clade F, member 1, serine (or cysteine) proteinase inhibitor, clade F), member 1, serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1, sserpin family F member 1
Species: rat

Top Publications

  1. ncbi Pigment epithelium-derived factor (PEDF) is an endogenous antiinflammatory factor
    Sarah X Zhang
    Department of Medicine Endocrinology, Department of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA
    FASEB J 20:323-5. 2006
  2. ncbi Changes in pigment epithelium-derived factor expression following kainic acid induced cerebellar lesion in rat
    Tomomi Sanagi
    Kitasato Institute for Life Sciences, Kitasato University, Tokyo, Japan
    Neurosci Lett 424:66-71. 2007
  3. pmc Pigment epithelium-derived factor stimulates tumor macrophage recruitment and is downregulated by the prostate tumor microenvironment
    Sofia Halin
    Department of Medical Biosciences, Pathology, Umea University, Umea, Sweden
    Neoplasia 12:336-45. 2010
  4. pmc Modulation of thrombospondin 1 and pigment epithelium-derived factor levels in vitreous fluid of patients with diabetes
    Shoujian Wang
    Department of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, 600 Highland Ave, K6 458 CSC, Madison, WI 53792 4673, USA
    Arch Ophthalmol 127:507-13. 2009
  5. ncbi Increased serum pigment epithelium-derived factor is associated with microvascular complications, vascular stiffness and inflammation in Type 1 diabetes
    A J Jenkins
    University of Melbourne, Department of Medicine, St Vincent s Hospital, Melbourne, Australia
    Diabet Med 24:1345-51. 2007
  6. ncbi Pigment epithelium-derived factor promotes the survival and differentiation of developing spinal motor neurons
    L J Houenou
    Department of Neurobiology and Anatomy, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    J Comp Neurol 412:506-14. 1999
  7. doi Hypoxia-induced upregulation of pigment epithelium-derived factor by retinal glial (Müller) cells
    Xiu Mei Yang
    Department of Ophthalmology and Eye Hospital, University of Leipzig, Leipzig, Germany
    J Neurosci Res 90:257-66. 2012
  8. pmc Overexpression of pigment epithelium-derived factor inhibits retinal inflammation and neovascularization
    Kyoungmin Park
    Department of Physiology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA
    Am J Pathol 178:688-98. 2011
  9. pmc Alterations of retinal pigment epithelium cause AMD-like retinopathy in senescence-accelerated OXYS rats
    Anton M Markovets
    Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia
    Aging (Albany NY) 3:44-54. 2011
  10. pmc Pigment epithelium-derived factor protects retinal ganglion cells
    Iok Hou Pang
    Alcon Research, Ltd, 6201 South Freeway, R3 24, Fort Worth, TX 76134, USA
    BMC Neurosci 8:11. 2007

Research Grants

Scientific Experts

Detail Information

Publications76

  1. ncbi Pigment epithelium-derived factor (PEDF) is an endogenous antiinflammatory factor
    Sarah X Zhang
    Department of Medicine Endocrinology, Department of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA
    FASEB J 20:323-5. 2006
    Pigment epithelium-derived factor (PEDF) is a potent angiogenic inhibitor. Reduced PEDF levels are associated with diabetic retinopathy...
  2. ncbi Changes in pigment epithelium-derived factor expression following kainic acid induced cerebellar lesion in rat
    Tomomi Sanagi
    Kitasato Institute for Life Sciences, Kitasato University, Tokyo, Japan
    Neurosci Lett 424:66-71. 2007
    Pigment epithelium-derived factor (PEDF) is a potent and broad-acting neurotrophic factor that protects various types of cultured neurons against glutamate excitotoxicity and induced apoptosis...
  3. pmc Pigment epithelium-derived factor stimulates tumor macrophage recruitment and is downregulated by the prostate tumor microenvironment
    Sofia Halin
    Department of Medical Biosciences, Pathology, Umea University, Umea, Sweden
    Neoplasia 12:336-45. 2010
    Pigment epithelium-derived factor (PEDF) is a potent inhibitor of angiogenesis but whether it has additional effects on the tumor microenvironment is largely unexplored...
  4. pmc Modulation of thrombospondin 1 and pigment epithelium-derived factor levels in vitreous fluid of patients with diabetes
    Shoujian Wang
    Department of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, 600 Highland Ave, K6 458 CSC, Madison, WI 53792 4673, USA
    Arch Ophthalmol 127:507-13. 2009
    To determine the levels of 2 endogenous inhibitors of angiogenesis, thrombospondin 1 (TSP-1) and pigment epithelium-derived factor (PEDF), in the vitreous fluid from patients with and without diabetes.
  5. ncbi Increased serum pigment epithelium-derived factor is associated with microvascular complications, vascular stiffness and inflammation in Type 1 diabetes
    A J Jenkins
    University of Melbourne, Department of Medicine, St Vincent s Hospital, Melbourne, Australia
    Diabet Med 24:1345-51. 2007
    To determine in Type 1 diabetes patients if levels of pigment epithelium-derived factor (PEDF), an anti-angiogenic, anti-inflammatory and antioxidant factor, are increased in individuals with complications and positively related to ..
  6. ncbi Pigment epithelium-derived factor promotes the survival and differentiation of developing spinal motor neurons
    L J Houenou
    Department of Neurobiology and Anatomy, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    J Comp Neurol 412:506-14. 1999
    Pigment epithelium-derived factor (PEDF) is a member of the serine protease inhibitor (serpin) superfamily that has been shown previously to promote the survival and/or differentiation of rat cerebellar granule neurons and human ..
  7. doi Hypoxia-induced upregulation of pigment epithelium-derived factor by retinal glial (Müller) cells
    Xiu Mei Yang
    Department of Ophthalmology and Eye Hospital, University of Leipzig, Leipzig, Germany
    J Neurosci Res 90:257-66. 2012
    ..Pigment epithelium-derived factor (PEDF), a neuroprotective protein and an inhibitor of angiogenesis, is produced by retinal glial (Müller) cells and can ..
  8. pmc Overexpression of pigment epithelium-derived factor inhibits retinal inflammation and neovascularization
    Kyoungmin Park
    Department of Physiology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA
    Am J Pathol 178:688-98. 2011
    Pigment epithelium-derived factor (PEDF) is a serine proteinase inhibitor with antiangiogenic activities...
  9. pmc Alterations of retinal pigment epithelium cause AMD-like retinopathy in senescence-accelerated OXYS rats
    Anton M Markovets
    Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia
    Aging (Albany NY) 3:44-54. 2011
    ..to clinical signs, morphology, and vascular endothelium growth factor (VEGF) and pigment epithelium-derived factor (PEDF) genes expression...
  10. pmc Pigment epithelium-derived factor protects retinal ganglion cells
    Iok Hou Pang
    Alcon Research, Ltd, 6201 South Freeway, R3 24, Fort Worth, TX 76134, USA
    BMC Neurosci 8:11. 2007
    ..Pigment epithelium-derived factor (PEDF) is a potent antiangiogenic, neurotrophic and neuroprotective protein that can protect neurons from a variety of ..
  11. ncbi Pigment epithelium-derived factor downregulates vascular endothelial growth factor (VEGF) expression and inhibits VEGF-VEGF receptor 2 binding in diabetic retinopathy
    Sarah X Zhang
    Department of Medicine, Department of Cell Biology, University of Oklahoma Health Sciences Center, 941 Stanton L Young Blvd, Oklahoma City, OK, USA
    J Mol Endocrinol 37:1-12. 2006
    ..vascular endothelial growth factor (VEGF), a major angiogenic stimulator, and pigment epithelium-derived factor (PEDF), a potent angiogenic inhibitor, is critical for the regulation of vascular permeability and angiogenesis...
  12. ncbi A PEDF N-terminal peptide protects the retina from ischemic injury when delivered in PLGA nanospheres
    Hong Li
    Department of Ophthalmology, Yale University School of Medicine, New Haven, CT, USA
    Exp Eye Res 83:824-33. 2006
    The neuroprotective effects of small pigment epithelium-derived factor (PEDF) peptides injected intravitreally as free peptides or delivered in poly(lactide-co-glycolide) (PLGA) nanospheres, were tested in retinal ischemic injury...
  13. ncbi Pigment epithelium-derived factor (PEDF) prevents diabetes- or advanced glycation end products (AGE)-elicited retinal leukostasis
    Sho ichi Yamagishi
    Department of Internal Medicine III, Kurume University School of Medicine, 67 Asahi Machi, Kurume 830 0011, Japan
    Microvasc Res 72:86-90. 2006
    Pigment epithelium-derived factor (PEDF) is the most potent inhibitor of angiogenesis in the mammalian eye, suggesting that PEDF may protect against proliferative diabetic retinopathy...
  14. ncbi High levels of pigment epithelium-derived factor in the retina of a rat model of type 2 diabetes
    Masato Matsuoka
    Department of Ophthalmology, Kansai Medical University, Fumizono cho 10 15, Moriguchi, Osaka 570 8507, Japan
    Exp Eye Res 82:172-8. 2006
    ..the retinal changes in SDT rats and determined the molecular balance between pigment epithelium-derived factor (PEDF), an angiogenic inhibitor, and vascular endothelial growth factor (VEGF), a major angiogenic stimulator...
  15. pmc Pigment epithelium-derived factor (PEDF) and vascular endothelial growth factor (VEGF) in aged human choroid and eyes with age-related macular degeneration
    Imran A Bhutto
    Department of Ophthalmology, The Wilmer Ophthalmological Institute, Johns Hopkins Hospital, Johns Hopkins University School of Medicine, 600 North Wolfe Street, Baltimore, MD 21287 9115, USA
    Exp Eye Res 82:99-110. 2006
    ..levels of vascular endothelial growth factor (VEGF; an angiogenic factor) and pigment epithelium-derived factor (PEDF; an antiangiogenic factor) in aged human choroid and to determine if the localization or their relative levels ..
  16. ncbi Decreased expression of pigment epithelium-derived factor is involved in the pathogenesis of diabetic nephropathy
    Joshua J Wang
    Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
    Diabetes 54:243-50. 2005
    Pigment epithelium-derived factor (PEDF) is a potent angiogenic inhibitor. Previous studies have shown that decreased ocular levels of PEDF are associated with diabetic retinopathy...
  17. ncbi Loss of the antiangiogenic pigment epithelium-derived factor in patients with angiogenic eye disease
    J Spranger
    University Hospital Benjamin Franklin, Free University of Berlin, Germany
    Diabetes 50:2641-5. 2001
    ..Retinal neovascularization characterizes proliferative diabetic retinopathy (PDR). Pigment epithelium-derived factor (PEDF) has been shown to be a major antiangiogenic growth factor in the mammalian eye...
  18. ncbi Vitreous levels of pigment epithelium-derived factor and vascular endothelial growth factor: implications for ocular angiogenesis
    Elia J Duh
    Department of Ophthalmology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Am J Ophthalmol 137:668-74. 2004
    Pigment epithelium-derived factor (PEDF) has been demonstrated to suppress ocular angiogenesis in several animal models...
  19. ncbi Pigment epithelium-derived factor inhibits retinal and choroidal neovascularization
    K Mori
    The Department of Ophthalmology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    J Cell Physiol 188:253-63. 2001
    In this study, we investigated whether overexpression of pigment epithelium-derived factor (PEDF) by gene transfer can inhibit neovascularization by testing its effect in three different models of ocular neovascularization...
  20. ncbi Pigment epithelium-derived factor delays the death of photoreceptors in mouse models of inherited retinal degenerations
    M Cayouette
    Faculte de Medecine, Centre de Recherche Universite Laval Robert Giffard, 2601, de la Canardière, Beauport, Quebec, G1J 2G3, Canada
    Neurobiol Dis 6:523-32. 1999
    Pigment epithelium-derived factor (PEDF) is a member of the serine protease inhibitor superfamily produced by retinal pigment epithelial cells in the developing and adult retina...
  21. ncbi Pigment epithelium-derived factor (PEDF) protects motor neurons from chronic glutamate-mediated neurodegeneration
    M M Bilak
    Department of Neurology, Johns Hopkins University, Baltimore, Maryland, USA
    J Neuropathol Exp Neurol 58:719-28. 1999
    Although pigment epithelium-derived factor (PEDF) is a neurotrophic factor that may aid the development, differentiation, and survival of adjacent neural retinae, the wider distribution of PEDF mRNA in the central nervous system suggested ..
  22. ncbi Pigment epithelium-derived factor suppresses ischemia-induced retinal neovascularization and VEGF-induced migration and growth
    Elia J Duh
    Department of Ophthalmology, Johns Hopkins University School of Medicine, Maumenee 809, 600 N Wolfe Street, Baltimore, MD 21287, USA
    Invest Ophthalmol Vis Sci 43:821-9. 2002
    To determine the effect of pigment epithelium-derived factor (PEDF) in a mouse model of ischemia-induced retinal neovascularization and on vascular endothelial growth factor (VEGF)--induced migration and growth of cultured microvascular ..
  23. ncbi Difference in ischemic regulation of vascular endothelial growth factor and pigment epithelium--derived factor in brown norway and sprague dawley rats contributing to different susceptibilities to retinal neovascularization
    Guoquan Gao
    Department of Ophthalmology, Medical University of South Carolina, Charleston, South Carolina 29403, USA
    Diabetes 51:1218-25. 2002
    ..basis responsible for the strain difference, we have measured the levels of pigment epithelium-derived factor (PEDF), an angiogenic inhibitor, and vascular endothelial growth factor (VEGF), a major angiogenic stimulator in the ..
  24. doi PEDF and 34-mer inhibit angiogenesis in the heart by inducing tip cells apoptosis via up-regulating PPAR-γ to increase surface FasL
    Hao Zhang
    Department of Thoracic Cardiovascular Surgery, Affiliated Hospital of Xuzhou Medical College, Xuzhou, 221006, China
    Apoptosis 21:60-8. 2016
    Pigment epithelial-derived factor (PEDF) is a potent anti-angiogenic factor whose effects are partially mediated through the induction of endothelial cell apoptosis...
  25. doi Regulation of vascular endothelial growth factor and pigment epithelium-derived factor in rat retinal explants under retinal acidification
    D Zhu
    Department of Ophthalmology, The First Affiliated Hospital, Shanghai Jiaotong University, Shanghai, China
    Eye (Lond) 23:2105-11. 2009
    To explore whether retinal acidification independently regulates the production of vascular endothelial growth factor (VEGF) and pigment epithelium-derived factor (PEDF) and whether the regulation is related to oxidative stress.
  26. doi Effect of high glucose concentration on VEGF and PEDF expression in cultured retinal Müller cells
    Hua Mu
    Department of Ophthalmology, Eye Hospital, The First Affiliated Hospital, Harbin Medical University, 23 Youzheng Road, 150001 Harbin, China
    Mol Biol Rep 36:2147-51. 2009
    ..of high glucose concentration on the expression of vascular endothelial growth factor (VEGF) and pigment epithelium derived factor (PEDF) in the cultured rat retinal Müller cells...
  27. doi PEDF inhibits growth of retinoblastoma by anti-angiogenic activity
    Huasheng Yang
    State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat Sen University, Guangzhou, China
    Cancer Sci 100:2419-25. 2009
    Pigment epithelium-derived factor (PEDF), an angiogenesis inhibitor with multiple other functions, balances angiogenesis in the eye and blocks tumor progression...
  28. doi Increased serum pigment epithelium-derived factor levels in type 1 diabetic patients with diabetic retinopathy
    Naoto Katakami
    Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    Diabetes Res Clin Pract 81:e4-7. 2008
    Serum pigment epithelium-derived factor (PEDF) levels were significantly higher in type 1 diabetic patients with retinopathy (n=20, 10.38+/-3.87 microg/ml) compared to the patients without it (n=57, 7.68+/-2.80 microg/ml) (p=0.0013)...
  29. doi Whole genome microarray of the major pelvic ganglion after cavernous nerve injury: new insights into molecular profile changes after nerve injury
    Giulia Calenda
    Albert Einstein College of Medicine, Bronx, NY, USA
    BJU Int 109:1552-64. 2012
    ....
  30. ncbi Pigment epithelium-derived factor (PEDF) administration inhibits occlusive thrombus formation in rats: a possible participation of reduced intraplatelet PEDF in thrombosis of acute coronary syndromes
    Katsuhiko Takenaka
    Department of Medicine, Division of Cardio Vascular Medicine, Kurume University School of Medicine, 67 Asahi Machi, Kurume 830 0011, Japan
    Atherosclerosis 197:25-33. 2008
    ..Pigment epithelium-derived factor (PEDF) has anti-oxidative properties and may play a protective role against atherosclerosis...
  31. pmc Pigment epithelium-derived factor inhibits neointimal hyperplasia after vascular injury by blocking NADPH oxidase-mediated reactive oxygen species generation
    Kazuo Nakamura
    Department of Medicine, Division of Cardio Vascular Medicine, Kurume University School of Medicine, 67 Asahi Machi, Kurume 830 0011, Japan
    Am J Pathol 170:2159-70. 2007
    Pigment epithelium-derived factor (PEDF) inhibits cytokine-induced endothelial cell activation through its antioxidative properties. However, the effect of PEDF on restenosis remains to be elucidated...
  32. ncbi Pigment epithelium-derived factor overexpression inhibits orthotopic osteosarcoma growth, angiogenesis and metastasis
    E T H Ek
    Department of Orthopaedics, University of Melbourne, St Vincent s Hospital, Melbourne, Victoria, Australia
    Cancer Gene Ther 14:616-26. 2007
    ..Pigment epithelium-derived factor (PEDF) has been shown to be one of the most potent inhibitors of angiogenesis, and more recently has demonstrated a ..
  33. ncbi Inhibition of orthotopic osteosarcoma growth and metastasis by multitargeted antitumor activities of pigment epithelium-derived factor
    Eugene T H Ek
    Department of Orthopaedics, University of Melbourne, St Vincent s Hospital, P O Box 2900, Fitzroy, Melbourne, 3065 VIC, Australia
    Clin Exp Metastasis 24:93-106. 2007
    ..In this study, we report the multimodal activity of pigment epithelium-derived factor (PEDF) in inhibiting osteosarcoma growth, angiogenesis and metastasis...
  34. doi PEDF attenuates hypoxia-induced apoptosis and necrosis in H9c2 cells by inhibiting p53 mitochondrial translocation via PEDF-R
    Xiaoyu Wang
    Department of Thoracic Cardiovascular Surgery, Affiliated Hospital of Xuzhou Medical College, 99 Huaihai road, Xuzhou 221006, Jiangsu Province, China
    Biochem Biophys Res Commun 465:394-401. 2015
    Pigment epithelial-derived factor (PEDF) is a multifunctional secreted glycoprotein, which could protect against hypoxia-induced cell death related to its anti-oxidative effect in cultured cardiomyocytes...
  35. pmc PEDF and PEDF-derived peptide 44mer stimulate cardiac triglyceride degradation via ATGL
    Hao Zhang
    Department of Thoracic and Cardiovascular Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China
    J Transl Med 13:68. 2015
    Pigment epithelium-derived factor (PEDF) is a 50-kDa secreted glycoprotein that is highly expressed in cardiomyocytes...
  36. pmc Host pigment epithelium-derived factor (PEDF) prevents progression of liver metastasis in a mouse model of uveal melanoma
    John M Lattier
    Department of Ophthalmology, Emory University, Atlanta, GA, USA
    Clin Exp Metastasis 30:969-76. 2013
    ..Pigment epithelium-derived factor (PEDF), an anti-angiogenic and anti-stromagenic protein, is produced by hepatocytes...
  37. doi Pigment epithelium-derived factor improves metabolic derangements and ameliorates dysregulation of adipocytokines in obese type 2 diabetic rats
    Takanori Matsui
    Department of Pathophysiology and Therapeutics of Diabetic Vascular Complications, Kurume University School of Medicine, Kurume, Japan
    Am J Pathol 184:1094-103. 2014
    ..Pigment epithelium-derived factor (PEDF) inhibits vascular inflammation through its anti-oxidative properties...
  38. ncbi Pigment epithelium-derived factor is elevated in CSF of patients with amyotrophic lateral sclerosis
    Ralph W Kuncl
    Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21218, USA
    J Neurochem 81:178-84. 2002
    Pigment epithelium-derived factor (PEDF), a recently defined retinal trophic factor and anti-angiogenic factor for the eye, is also present in the CNS and is a motor neuron protectant...
  39. pmc Protective role of small pigment epithelium-derived factor (PEDF) peptide in diabetic renal injury
    Alaa S Awad
    Associate Professor of Medicine, and Cellular and Molecular Physiology, Penn State Univ, Hershey Medical Center, College of Medicine, Division of Nephrology, H040, 500 Univ Drive, P O Box 850, BMR Bldg, C5830, Hershey, PA 17033
    Am J Physiol Renal Physiol 305:F891-900. 2013
    Pigment epithelium-derived factor (PEDF) is a multifunctional protein with antiangiogenic, antioxidative, and anti-inflammatory properties...
  40. ncbi Aqueous humor levels of vascular endothelial growth factor and pigment epithelium-derived factor in polypoidal choroidal vasculopathy and choroidal neovascularization
    Jian Ping Tong
    Department of Ophthalmology and Visual Sciences, Chinese University of Hong Kong, Hong Kong Eye Hospital, 147K Argyle Street, Kowloon, Hong Kong, PRC
    Am J Ophthalmol 141:456-62. 2006
    To determine the aqueous levels of vascular endothelial growth factor (VEGF) and pigment epithelium-derived factor (PEDF) in patients with active polypoidal choroidal vasculopathy (PCV) and choroidal neovascularization (CNV) secondary to ..
  41. doi Rosiglitazone inhibits expression and secretion of PEDF in adipose tissue and liver of male SD rats via a PPAR-γ independent mechanism
    Shumin Yang
    Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China
    Endocrinology 155:941-50. 2014
    Pigment epithelium-derived factor (PEDF) plays an important role in insulin resistance (IR). The study aims to investigate the effect of rosiglitazone, an insulin sensitizer, on PEDF production and release both in vivo and in vitro...
  42. ncbi Salutary effect of pigment epithelium-derived factor in diabetic nephropathy: evidence for antifibrogenic activities
    Joshua J Wang
    Department of Medicine Endocrinology, University of Oklahoma Health Sciences Ceter, Oklahoma City, Oklahoma, USA
    Diabetes 55:1678-85. 2006
    ..S. Pigment epithelium-derived factor (PEDF) is a potent angiogenic inhibitor that has been extensively studied in diabetic retinopathy...
  43. ncbi Expression of pigment epithelium-derived factor (PEDF) and vascular endothelial growth factor (VEGF) in sickle cell retina and choroid
    Sahng Yeon Kim
    The Wilmer Ophthalmological Institute, Department of Ophthalmology, School of Medicine, The Johns Hopkins University, Baltimore, MD 21287 9115, USA
    Exp Eye Res 77:433-45. 2003
    Pigment epithelium-derived factor (PEDF) has been shown to be an inhibitor of angiogenesis as well as a multipotent neurotrophic factor in the mammalian eye...
  44. doi Pigment epithelial-derived factor expression in endometriotic lesions in a rat model of endometriosis
    Guofang Fu
    Women s Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310006, PR China
    Acta Histochem 115:301-7. 2013
    ..Angiogenesis is a prerequisite for endometriotic lesion formation and development. Pigment epithelium-derived factor (PEDF) is a potential inhibitor of angiogenesis...
  45. doi Role of pigment epithelium-derived factor (PEDF) in arsenic-induced cell apoptosis of liver and brain in a rat model
    Wei Zhang
    Center for Endemic Disease Control, Chinese Center for Disease Control and Prevention, Harbin Medical University, Harbin, China
    Biol Trace Elem Res 151:269-76. 2013
    ..on our previous study on human serum, the present study was to determine whether pigment epithelium-derived factor (PEDF) plays a role in the damage induced by chronic arsenic exposure in a rat model and to explore the possible ..
  46. doi Effects of intravitreal triamcinolone acetonide on retinal gene expression in a rat model of central retinal vein occlusion
    Matus Rehak
    Department of Ophthalmology and Eye Hospital, University of Leipzig, Faculty of Medicine, Liebigstrasse 10 14, 04103 Leipzig, Germany
    Graefes Arch Clin Exp Ophthalmol 249:1175-83. 2011
    ..The aim of this study was to investigate the effects of intravitreal triamcinolone acetonide on the alterations in retinal gene expression in a rat model of central retinal vein occlusion (CRVO)...
  47. doi Effect of pigment epithelium-derived factor on glutamate uptake in retinal Muller cells under high-glucose conditions
    Bing Xie
    Department of Ophthalmology, Ruijin Hospital, School of Medicine, The Jiaotong University, Shanghai, China
    Invest Ophthalmol Vis Sci 53:1023-32. 2012
    ..The present study was performed to determine the role of pigment epithelium-derived factor (PEDF) in glutamate uptake in retinal Müller cells in high-glucose conditions.
  48. doi The intrinsic PEDF is regulated by PPARγ in permanent focal cerebral ischemia of rat
    Chunhua Zhu
    Department of Neurology, Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, People s Republic of China
    Neurochem Res 37:2099-107. 2012
    ..Pigment epithelium-derived factor (PEDF) is proven to possess neuroprotective property...
  49. doi Influence of lactic acid on differential expression of vascular endothelial growth factor and pigment epithelium-derived factor in explants of rat retina
    Dongqing Zhu
    Department of Ophthalmology, Shanghai First People s Hospital, Shanghai, China
    Curr Eye Res 37:1025-9. 2012
    To investigate the influence of lactate on expression of vascular endothelial growth factor (VEGF) and pigment epithelium-derived factor (PEDF) in rat retina.
  50. pmc Age-related decrease in cerebrovascular-derived neuroprotective proteins: effect of acetaminophen
    Debjani Tripathy
    Garrison Institute on Aging, Texas Tech University Health Sciences Center, Lubbock, Texas 79430, USA
    Microvasc Res 84:278-85. 2012
    ..neuroprotective proteins, Such as vascular endothelial growth factor (VEGF), pigment epithelium-derived factor (PEDF), and pituitary adenylate cyclase activating peptide (PACAP) are important for maintaining neuronal viability, ..
  51. pmc Therapeutic action of the mitochondria-targeted antioxidant SkQ1 on retinopathy in OXYS rats linked with improvement of VEGF and PEDF gene expression
    Anton M Markovets
    Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia
    PLoS ONE 6:e21682. 2011
    ..of angiogenesis vascular endothelial growth factor A (VEGF) and its antagonist pigment epithelium-derived factor (PEDF) genes in the retina of OXYS rats as evidenced by real-time PCR and an ELISA test for VEGF using Wistar rats as ..
  52. pmc Nuclear receptor co-repressor is required to maintain proliferation of normal intestinal epithelial cells in culture and down-modulates the expression of pigment epithelium-derived factor
    Geneviève Doyon
    Département d Anatomie et Biologie Cellulaire, Faculte de Medecine et des Sciences de la Sante, Universite de Sherbrooke, Sherbrooke, Quebec J1H 5N4, Canada
    J Biol Chem 284:25220-9. 2009
    ..Pigment epithelium-derived factor (PEDF, also known as serpinf1), a suspected tumor suppressor gene that plays a key role in the inhibition of epithelial ..
  53. pmc Increased serum pigment epithelium derived factor levels in Type 2 diabetes patients
    Alicia Jenkins
    Department of Medicine, Endocrinology, Harold Hamm Oklahoma Diabetes Center, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
    Diabetes Res Clin Pract 82:e5-7. 2008
    Serum PEDF levels (mean (S.D.)) were increased in 96 Type 2 diabetic vs. 54 non-diabetic subjects; 5.3 (2.8) vs. 3.2 (2.0)mug/ml, p<0.001...
  54. pmc Changes in growth factor expression in normal aging of the rat retina
    Christopher P Smith
    Department of Physiology, Southern Illinois University School of Medicine, Carbondale, IL 62901, USA
    Exp Eye Res 85:817-24. 2007
    ..and protein analysis was conducted to investigate steady state mRNA expression and protein levels of VEGF, VEGFR2, PEDF, Ang-1, Tie-2, EphB4 and ephrinB2 in the retina of 8-, 22-, and 32-month-old Brown Norway X Fischer 344 F1 hybrid ..
  55. ncbi Decreased pigment epithelium-derived factor is associated with metastatic phenotype in human and rat prostate tumors
    Sofia Halin
    Department of Medical Biosciences, Umea University, Umea, Sweden
    Cancer Res 64:5664-71. 2004
    ..These observations indicate that loss of pigment epithelium-derived factor expression could be associated with the progression toward a metastatic phenotype in prostate cancer...
  56. ncbi Pigment epithelium-derived factor induces pro-inflammatory genes in neonatal astrocytes through activation of NF-kappa B and CREB
    Takeshi Yabe
    Kitasato Institute for Life Sciences, Kitasato University, Tokyo 108 8641, Japan
    Glia 50:223-34. 2005
    Pigment epithelium-derived factor (PEDF) is a potent and broadly acting neurotrophic factor that protects neurons in various types of cultured neurons against glutamate excitotoxicity and induced-apoptosis...
  57. ncbi [Expression and signification of pigment epithelium-derived factor in experimental choroidal neovascularization of rat]
    Xue hui Shi
    Department of Ophthalmology, General Hospital of PLA, Beijing 100853, China
    Zhonghua Yan Ke Za Zhi 40:404-8. 2004
    ..To investigate the expression and signification of pigment epithelium-derived factor in choroidal neovascularization (CNV) induced by krypton laser on Brown Norway rat...
  58. ncbi Retinoic acid and dexamethasone regulate the expression of PEDF in retinal and endothelial cells
    J Tombran-Tink
    Division of Pharmaceutical Sciences, University of Missouri Kansas City, Kansas City, MO, USA
    Exp Eye Res 78:945-55. 2004
    Both all-trans-retinoic acid (ATRA) and pigment epithelial-derived factor (PEDF) regulate cell proliferation and differentiation...
  59. ncbi Lack of alpha 2-antiplasmin promotes re-endothelialization via over-release of VEGF after vascular injury in mice
    Hiroyuki Matsuno
    Department of Pharmacology, Gifu University School of Medicine, Tsukasa machi 40, Gifu 500 8705, Japan
    Blood 102:3621-8. 2003
    ..Our results provide new insight into the role of alpha 2-AP and VEGF in the pathogenesis of re-endothelialization following vascular injury...
  60. ncbi Pigment epithelium-derived factor targets endothelial and epithelial cells in Wilms' tumor
    Lisa P Abramson
    Division of Pediatric Surgery, Children s Memorial Hospital, Chicago, IL 60614, USA
    J Pediatr Surg 41:1351-6. 2006
    Loss of pigment epithelium-derived factor (PEDF), a potent inhibitor of angiogenesis, has been linked to progression of angiogenesis-dependent diseases...
  61. ncbi Hexapeptides HLDF-6 and PEDF-6 restore memory in rats after chronic intracerebroventricular treatment with beta-amyloid peptide Abeta(25-35)
    Z I Storozheva
    Laboratory of Neurochemistry, P K Anokhin Institute of Normal Physiology, Russian Academy of Medical Sciences
    Bull Exp Biol Med 141:319-22. 2006
    Effects of homologous peptides HLDF-6 and PEDF-6 on behavior of animals with experimental Alzheimer's disease induced by chronic intracerebroventricular administration of beta-amyloid peptide Abeta(25-35) were studied in the zoosocial ..
  62. pmc Visceral obesity and hemostatic profile in patients with type 2 diabetes: the effect of gender and metabolic compensation
    Elzbieta Kozek
    Department of Metabolic Diseases, Jagiellonian University, Medical College, 15 Kopernika Street, 31 501 Krakow, Poland
    Rev Diabet Stud 1:122-8. 2004
    ..Type 2 diabetes (T2DM) patients are characterized by a very high risk of cardiovascular diseases. Among the factors that are responsible for this phenomenon are abdominal obesity and hemostatic abnormalities...
  63. ncbi Expression of pigment-epithelium-derived factor during kidney development and aging
    Ana Luisa Pina
    Department of Neurosurgery, University Clinic of Regensburg, Franz Josef Strauss Allee 11, 93053, Regensburg, Germany
    Cell Tissue Res 329:329-38. 2007
    ..In the adult kidney, one of the major inhibitors of angiogenesis is pigment-epithelium-derived factor (PEDF)...
  64. ncbi Promoter polymorphisms of the pigment epithelium-derived factor gene are associated with diabetic retinopathy
    Hiroyuki Iizuka
    Division of RI Laboratory, Biomedical Research Center, Saitama Medical University, Saitama, Japan
    Biochem Biophys Res Commun 361:421-6. 2007
    Pigment epithelium-derived factor (PEDF or SERPINF1), a neuroprotective and anti-angiogenic factor, may play an important role in the pathogenesis of diabetic retinopathy (DR)...
  65. ncbi Insulin-like growth factors, angiopoietin-2, and pigment epithelium-derived growth factor in the hypoxic retina
    V Sivakumar
    Department of Anatomy, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
    J Neurosci Res 86:702-11. 2008
    ..growth factor-I (IGF-I) and -II (IGF-II), angiopoietin-2 (Ang-2), and pigment epithelium-derived growth factor (PEDF) in normal and hypoxic retinas of adult rats...
  66. ncbi Vitreous fluid of db/db mice exhibits alterations in angiogenic and metabolic factors consistent with early diabetic retinopathy
    Margo P Cohen
    Glycadia, Inc, Philadelphia, PA, USA
    Ophthalmic Res 40:5-9. 2008
    ....
  67. doi Anti-inflammatory effects of pigment epithelium-derived factor in diabetic nephropathy
    Joshua J Wang
    Department of Medicine Endocrinology and Cell Biology, Dean A McGee Eye Institute, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, USA
    Am J Physiol Renal Physiol 294:F1166-73. 2008
    Previously, we have reported that pigment epithelium-derived factor (PEDF) ameliorates albuminuria and inhibits matrix protein deposition in the kidney of streptozotocin (STZ)-induced diabetic rats, suggesting a renoprotective effect of ..
  68. ncbi [Pigment epithelium-derived factor expression in the retina in response to hypobaric hypoxia]
    Yong Zhang
    Department of Ophthalmology, the First Hospital Affiliated to Kunming Medical College, Kunming 650031, China
    Zhonghua Yan Ke Za Zhi 43:1130-4. 2007
    The present study was undertaken to examine the expression of pigment epithelium-derived factor (PEDF) in the retina of adult rat following hypobaric hypoxic exposures.
  69. doi Protein expression of pigment-epithelium-derived factor in rat cochlea
    Otto Gleich
    Department of Otorhinolaryngology, University of Regensburg, Regensburg, Germany
    Cell Tissue Res 332:565-71. 2008
    Pigment-epithelium-derived factor (PEDF) is a 50-kDa glycoprotein with well-recognised expression in various mammalian organs showing diverse (e.g. anti-angiogenic and neuroprotective) activities...
  70. doi Gene transfer of PEDF attenuates ischemic brain damage in the rat middle cerebral artery occlusion model
    Tomomi Sanagi
    Kitasato Institute for Life Sciences, Graduate School of Infection Control Sciences, Kitasato University, Tokyo, Japan
    J Neurochem 106:1841-54. 2008
    Pigment epithelium-derived factor (PEDF) is a 50-kDa glycoprotein that protects various types of cultured neurons against neurotoxic stimuli, but its precise role in the CNS is not fully understood...
  71. ncbi Extracellular phosphorylation converts pigment epithelium-derived factor from a neurotrophic to an antiangiogenic factor
    Galia Maik-Rachline
    Department of Biological Regulation, The Weizmann Institute of Science, Rehovot, Israel
    Blood 105:670-8. 2005
    The pigment epithelium-derived factor (PEDF) belongs to the superfamily of serine protease inhibitors (serpin)...
  72. pmc Ethanol exposure depletes hepatic pigment epithelium-derived factor, a novel lipid regulator
    Chuhan Chung
    Department of Medicine, Section of Digestive Diseases, Yale University School of Medicine, New Haven, Connecticut 06516, USA
    Gastroenterology 136:331-340.e2. 2009
    ..Pigment epithelium-derived factor (PEDF) is a multifunctional secreted glycoprotein that is expressed by hepatocytes...
  73. doi Administration of pigment epithelium-derived factor (PEDF) reduces proteinuria by suppressing decreased nephrin and increased VEGF expression in the glomeruli of adriamycin-injected rats
    Toshiko Fujimura
    Division of Nephrology, Department of Medicine, Kurume University School of Medicine, Kurume, Japan
    Nephrol Dial Transplant 24:1397-406. 2009
    Pigment epithelium-derived factor (PEDF) is a glycoprotein with potent neuronal differentiating activity...
  74. pmc Protective effect of perindopril on diabetic retinopathy is associated with decreased vascular endothelial growth factor-to-pigment epithelium-derived factor ratio: involvement of a mitochondria-reactive oxygen species pathway
    Zhi Zheng
    Department of Ophthalmology, First People s Hospital of Shanghai, Shanghai Jiaotong University, Shanghai, China
    Diabetes 58:954-64. 2009
    ..to verify whether the decreased vascular endothelial growth factor (VEGF)-to-pigment epithelium-derived factor (PEDF) ratio can serve as an indicator for the protective effect of angiotensin-converting enzyme inhibitors (ACEIs) on ..

Research Grants5

  1. Thrombospondin-1 in prostate development and neoplasia
    Susan Crawford; Fiscal Year: 2004
    ..Results from these experiments should establish the function of TSP-1 in prostatic growth regulation and determine how TSP-1 may be useful as a prognostic indicator or as a treatment for prostatic diseases. ..
  2. Point-of-Care Measurement of Glycated Hemoglobin
    MARGO COHEN; Fiscal Year: 2004
    ....
  3. Inhibition of CNV using a transgenic PEDF model
    Elia Duh; Fiscal Year: 2004
    ..Specifically, we propose to study the effects of pigment epithelium-derived factor (PEDF), which has emerged as a potent inhibitor of angiogenesis, with dramatic inhibitory effects on corneal, retinal, ..
  4. Reducing Renal TGF-B in Diabetic Glomerulosclerosis
    MARGO COHEN; Fiscal Year: 2005
    ..abstract_text> ..
  5. LDL Modification in Diabetic Complications
    MARGO COHEN; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..