Pgrmc1

Summary

Gene Symbol: Pgrmc1
Description: progesterone receptor membrane component 1
Alias: 25-Dx, 25Dx, MPR, VEMA, membrane-associated progesterone receptor component 1, acidic 25 kDa protein, membrane-bound progesterone receptor, ventral midline antigen
Species: rat

Top Publications

  1. pmc Distribution of mRNAs encoding classical progestin receptor, progesterone membrane components 1 and 2, serpine mRNA binding protein 1, and progestin and ADIPOQ receptor family members 7 and 8 in rat forebrain
    K A Intlekofer
    Center for Neuroendocrinology, University of Massachusetts, Amherst, MA 01003, USA
    Neuroscience 172:55-65. 2011
  2. pmc Progesterone inhibits apoptosis in part by PGRMC1-regulated gene expression
    J J Peluso
    Department of Cell Biology, University of Connecticut Health Center, Farmington, CT 06030, USA
    Mol Cell Endocrinol 320:153-61. 2010
  3. doi The PGRMC1 Protein Level Correlates with the Binding Activity of a Sigma-2 Fluorescent Probe (SW120) in Rat Brain Cells
    Chenbo Zeng
    Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA
    Mol Imaging Biol 18:172-9. 2016
  4. pmc Progesterone receptor membrane component-1 (PGRMC1) and PGRMC-2 interact to suppress entry into the cell cycle in spontaneously immortalized rat granulosa cells
    John J Peluso
    Department of Cell Biology, University of Connecticut Health Center, Farmington, Connecticut Department of Obstetrics and Gynecology, University of Connecticut Health Center, Farmington, Connecticut
    Biol Reprod 91:104. 2014
  5. pmc Progesterone antagonism of neurite outgrowth depends on microglial activation via Pgrmc1/S2R
    N Bali
    Molecular Biology Program, University of Southern California, Los Angeles, CA 90089, USA
    Endocrinology 154:2468-80. 2013
  6. pmc Progesterone receptor membrane component-1 (PGRMC1) is the mediator of progesterone's antiapoptotic action in spontaneously immortalized granulosa cells as revealed by PGRMC1 small interfering ribonucleic acid treatment and functional analysis of PGRMC1 m
    John J Peluso
    Department of Cell Biology, University of Connecticut Health Center, Farmington, CT 06030, USA
    Endocrinology 149:534-43. 2008
  7. pmc Plasminogen activator inhibitor 1 RNA-binding protein interacts with progesterone receptor membrane component 1 to regulate progesterone's ability to maintain the viability of spontaneously immortalized granulosa cells and rat granulosa cells
    John J Peluso
    Department of Cell Biology, University of Connecticut Health Center, Farmington, CT 06030, USA
    Biol Reprod 88:20. 2013
  8. doi Distribution of membrane progesterone receptor alpha in the male mouse and rat brain and its regulation after traumatic brain injury
    D Meffre
    UMR 788 INSERM and University Paris Sud, 94276 Kremlin Bicêtre, France
    Neuroscience 231:111-24. 2013
  9. pmc A novel role for progesterone and progesterone receptor membrane component 1 in regulating spindle microtubule stability during rat and human ovarian cell mitosis
    Valentina Lodde
    Department of Cell Biology, University of Connecticut Health Center, Farmington, CT, USA
    Biol Reprod 84:715-22. 2011
  10. pmc Progesterone increases the release of brain-derived neurotrophic factor from glia via progesterone receptor membrane component 1 (Pgrmc1)-dependent ERK5 signaling
    Chang Su
    Department of Pharmacology and Neuroscience, Institute for Aging and Alzheimer s Disease Research, University of North Texas Health Science Center at Fort Worth, 3400 Camp Bowie Boulevard, Fort Worth, Texas 76107, USA
    Endocrinology 153:4389-400. 2012

Scientific Experts

  • John Peluso
  • Ornella I Selmin
  • Chenbo Zeng
  • Robert H Mach
  • D Meffre
  • N Bali
  • Chang Su
  • Namrata Bali
  • Valentina Lodde
  • K A Intlekofer
  • Jinbin Xu
  • Gavin P Vinson
  • Li Min
  • Delphine Meffre
  • H Sakamoto
  • Val Leel
  • Neha Garg
  • B Delespierre
  • M Schumacher
  • F Labombarda
  • A Chastre
  • T E Morgan
  • R Guennoun
  • A F De Nicola
  • D G Stein
  • J M Arimoto
  • C E Finch
  • Meharvan Singh
  • Rebecca L Cunningham
  • Roberta D Brinton
  • Caleb E Finch
  • Sharon W Lin
  • Jason M Arimoto
  • Todd E Morgan
  • Nahoko Iwata
  • Liqin Zhao
  • Nataliya Rybalchenko
  • Dexing Zeng
  • S L Petersen
  • William G Hawkins
  • Dirk Spitzer
  • Richard S Hotchkiss
  • Fenghui Pan
  • Kenneth T Wheeler
  • Dong Zhou
  • Zhude Tu
  • Katherine C Chang
  • Fanjie Zhang
  • Wenhua Chu
  • Fabian Johnston
  • Justin M Rothfuss
  • Suwanna Vangveravong
  • I Nolte
  • E Runko
  • Michael Schumacher
  • Ivan N Harnastai
  • Donald G Stein
  • Rachida Guennoun
  • Monique Gouézou
  • Hiroshi Takemori
  • Natallia V Strushkevich
  • Philippe Leclerc
  • Mitsuhiro Okamoto
  • Andrei A Gilep
  • Sergey A Usanov
  • Brigitte Delespierre
  • Hiroshi Hori
  • Hiroko Iwamoto
  • Yasuki Nonaka
  • H Takemori
  • Matthew C Wright
  • Lucy J Elrick
  • K Tsutsui
  • K Ukena
  • Andrew J Porter
  • Jorges Solares
  • M Kawata
  • Nicola Ingram
  • Keith A Charlton
  • M Okamoto
  • F T Wieland
  • D Jeckel
  • K Sohn
  • C Wideman
  • Z Kaprielian

Detail Information

Publications21

  1. pmc Distribution of mRNAs encoding classical progestin receptor, progesterone membrane components 1 and 2, serpine mRNA binding protein 1, and progestin and ADIPOQ receptor family members 7 and 8 in rat forebrain
    K A Intlekofer
    Center for Neuroendocrinology, University of Massachusetts, Amherst, MA 01003, USA
    Neuroscience 172:55-65. 2011
    ..These include progesterone receptor membrane component 1 (Pgrmc1), Pgrmc2, progestin and adipoQ receptor 7 (Paqr7) and Paqr8...
  2. pmc Progesterone inhibits apoptosis in part by PGRMC1-regulated gene expression
    J J Peluso
    Department of Cell Biology, University of Connecticut Health Center, Farmington, CT 06030, USA
    Mol Cell Endocrinol 320:153-61. 2010
    Progesterone receptor membrane component-1 (PGRMC1) is present in both the cytoplasm and nucleus of spontaneously immortalized granulosa cells (SIGCs)...
  3. doi The PGRMC1 Protein Level Correlates with the Binding Activity of a Sigma-2 Fluorescent Probe (SW120) in Rat Brain Cells
    Chenbo Zeng
    Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA
    Mol Imaging Biol 18:172-9. 2016
    We examined the progesterone receptor membrane component 1 (PGRMC1) protein expression in rat brain cells as the prerequisite step to understand the biology of PGRMC1 in the central nervous system (CNS)...
  4. pmc Progesterone receptor membrane component-1 (PGRMC1) and PGRMC-2 interact to suppress entry into the cell cycle in spontaneously immortalized rat granulosa cells
    John J Peluso
    Department of Cell Biology, University of Connecticut Health Center, Farmington, Connecticut Department of Obstetrics and Gynecology, University of Connecticut Health Center, Farmington, Connecticut
    Biol Reprod 91:104. 2014
    Progesterone receptor membrane component 1 (PGRMC1) and PGRMC2 are expressed in rat granulosa cells and spontaneously immortalized granulosa cells (SIGCs) but their biological roles are not well defined...
  5. pmc Progesterone antagonism of neurite outgrowth depends on microglial activation via Pgrmc1/S2R
    N Bali
    Molecular Biology Program, University of Southern California, Los Angeles, CA 90089, USA
    Endocrinology 154:2468-80. 2013
    ..of neurite outgrowth is mediated by microglial expression of progesterone receptor (Pgr) membrane component 1 (Pgrmc1)/S2R, a putative nonclassical Pgr mediator with multiple functions...
  6. pmc Progesterone receptor membrane component-1 (PGRMC1) is the mediator of progesterone's antiapoptotic action in spontaneously immortalized granulosa cells as revealed by PGRMC1 small interfering ribonucleic acid treatment and functional analysis of PGRMC1 m
    John J Peluso
    Department of Cell Biology, University of Connecticut Health Center, Farmington, CT 06030, USA
    Endocrinology 149:534-43. 2008
    Progesterone (P4) receptor membrane component-1 (PGRMC1) and its binding partner, plasminogen activator inhibitor 1 RNA binding protein (PAIRBP1) are thought to form a complex that functions as membrane receptor for P4...
  7. pmc Plasminogen activator inhibitor 1 RNA-binding protein interacts with progesterone receptor membrane component 1 to regulate progesterone's ability to maintain the viability of spontaneously immortalized granulosa cells and rat granulosa cells
    John J Peluso
    Department of Cell Biology, University of Connecticut Health Center, Farmington, CT 06030, USA
    Biol Reprod 88:20. 2013
    Progesterone receptor membrane component 1 (PGRMC1) mediates the antiapoptotic action of progesterone (P4)...
  8. doi Distribution of membrane progesterone receptor alpha in the male mouse and rat brain and its regulation after traumatic brain injury
    D Meffre
    UMR 788 INSERM and University Paris Sud, 94276 Kremlin Bicêtre, France
    Neuroscience 231:111-24. 2013
    ..to intracellular progesterone receptors, membrane receptors of the hormone such as membrane progesterone receptor (mPR) may also be involved in neuroprotection...
  9. pmc A novel role for progesterone and progesterone receptor membrane component 1 in regulating spindle microtubule stability during rat and human ovarian cell mitosis
    Valentina Lodde
    Department of Cell Biology, University of Connecticut Health Center, Farmington, CT, USA
    Biol Reprod 84:715-22. 2011
    ..studies were designed to assess the roles of progesterone (P4) and Progesterone Receptor Membrane Component 1 (PGRMC1) in regulating mitosis of spontaneously immortalized granulosa cells (SIGCs) and ovarian cancer cells, SKOV-3 ..
  10. pmc Progesterone increases the release of brain-derived neurotrophic factor from glia via progesterone receptor membrane component 1 (Pgrmc1)-dependent ERK5 signaling
    Chang Su
    Department of Pharmacology and Neuroscience, Institute for Aging and Alzheimer s Disease Research, University of North Texas Health Science Center at Fort Worth, 3400 Camp Bowie Boulevard, Fort Worth, Texas 76107, USA
    Endocrinology 153:4389-400. 2012
    ..and examined the role of the classical PR and a putative membrane PR, progesterone receptor membrane component-1 (Pgrmc1), as mediators of this response...
  11. pmc Differential responses of progesterone receptor membrane component-1 (Pgrmc1) and the classical progesterone receptor (Pgr) to 17β-estradiol and progesterone in hippocampal subregions that support synaptic remodeling and neurogenesis
    Namrata Bali
    University of Southern California Dornsife College of Letters, Arts and Sciences, Los Angeles, California 90089 0191, USA
    Endocrinology 153:759-69. 2012
    ..We examined the neuronal expression of progesterone receptor membrane component-1 (Pgrmc1) and the classical progesterone receptor (Pgr), by in situ hybridization and immunohistochemistry...
  12. pmc Progesterone regulation of progesterone receptor membrane component 1 (PGRMC1) sumoylation and transcriptional activity in spontaneously immortalized granulosa cells
    John J Peluso
    Department of Cell Biology, University of Connecticut Health Center, Farmington, Connecticut 06030, USA
    Endocrinology 153:3929-39. 2012
    ..That these higher molecular mass bands represent PGRMC1 is supported by the findings that they are not detected when either the primary antibody is omitted or the PGRMC1 ..
  13. pmc Identification of the PGRMC1 protein complex as the putative sigma-2 receptor binding site
    Jinbin Xu
    Division of Radiological Sciences, Department of Radiology, Mail Box 8225, Washington University School of Medicine, 510 S Kingshighway Boulevard, St Louis, Missouri 63110, USA
    Nat Commun 2:380. 2011
    ..group, irreversibly labels sigma-2 receptors in rat liver; the membrane-bound protein was identified as PGRMC1 (progesterone receptor membrane component 1)...
  14. ncbi Isolation and characterization of a novel gene induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin in rat liver
    O Selmin
    Laboratory of Computational Biology and Risk Analysis, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Carcinogenesis 17:2609-15. 1996
    ....
  15. ncbi Cloning and expression of VEMA: a novel ventral midline antigen in the rat CNS
    E Runko
    Department of Neuroscience, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Mol Cell Neurosci 14:428-43. 1999
    ..We report here the isolation of cDNA clones encoding the mAb CARO 2 antigen, which we rename VEMA, for ventral midline antigen. The deduced amino acid sequence of VEMA contains a single transmembrane domain near its N-terminus and ..
  16. ncbi Expression and localization of 25-Dx, a membrane-associated putative progesterone-binding protein, in the developing Purkinje cell
    H Sakamoto
    Laboratory of Brain Science, Faculty of Integrated Arts and Sciences, Hiroshima University, Japan
    Neuroscience 126:325-34. 2004
    ..Progesterone may promote dendritic growth, spinogenesis and synaptogenesis via 25-Dx as well as its nuclear receptor in the Purkinje cell in the neonate...
  17. ncbi Localization and topology of ratp28, a member of a novel family of putative steroid-binding proteins
    I Nolte
    Biochemie Zentrum, Heidelberg BZH, University of Heidelberg, Im Neuenheimer Feld, 328, D 69120, Heidelberg, Germany
    Biochim Biophys Acta 1543:123-30. 2000
    ..In these experiments no association was found with markers for Golgi or plasma membranes, indicating that ratp28 is localized to the endoplasmic reticulum...
  18. ncbi Identification of a truncated ratp28-related protein expressed in kidney
    Val Leel
    Department of Molecular and Cell Biology, Institute of Medical Sciences, University of Aberdeen, Aberdeen, UK
    Biochem Biophys Res Commun 316:872-7. 2004
    ..Western blotting identified a 10kDa protein in cytosolic fractions of rat kidney. The function of HC5 remains to be determined...
  19. ncbi Molecular identification of adrenal inner zone antigen as a heme-binding protein
    Li Min
    Department of Molecular Physiological Chemistry, Graduate School of Medicine, Osaka University, Japan
    FEBS J 272:5832-43. 2005
    ..The effect of IZA on the steroid 21-hydroxylation reaction was investigated in COS-7 cell expression systems. The results suggest that the coexistence of IZA with CYP21 enhances 21-hydroxylase activity...
  20. ncbi The membrane-associated progesterone-binding protein 25-Dx is expressed in brain regions involved in water homeostasis and is up-regulated after traumatic brain injury
    Delphine Meffre
    INSERM U488, Stéroïdes et Système Nerveux, Kremlin Bicetre, France
    J Neurochem 93:1314-26. 2005
    ....
  21. ncbi Transcriptional activation of the membrane-bound progesterone receptor (mPR) by dioxin, in endocrine-responsive tissues
    Ornella Selmin
    Department of Veterinary Sciences and Microbiology, University of Arizona, Tucson, AZ 87524, USA
    Mol Reprod Dev 70:166-74. 2005
    We originally identified the membrane-bound progesterone receptor (mPR) using a screening for genes differentially expressed in liver of rats exposed to dioxin...

Research Grants3

  1. Regulation of Oocyte Viability by Granulosa Cell Contact
    John Peluso; Fiscal Year: 2004
    ..abstract_text> ..
  2. Protein Kinase G Regulation of Granulosa Cell Viability
    John Peluso; Fiscal Year: 2006
    ..We now propose to test this hypothesis using biochemical, genetic, imaging and cell biological techniques. [unreadable] [unreadable]..
  3. Progesterone regulation of human luteal cell viability
    John Peluso; Fiscal Year: 2006
    ..Such selective manipulation of the P4's actions could have far reaching effects on the treatment for infertility, contraception and certain types of cancers. [unreadable] [unreadable]..