peroxisome proliferator activated receptor gamma

Summary

Gene Symbol: peroxisome proliferator activated receptor gamma
Description: peroxisome proliferator-activated receptor gamma
Alias: peroxisome proliferator-activated receptor gamma, PPAR-gamma, nuclear receptor subfamily 1 group C member 3, peroxisome proliferator activator receptor, gamma
Species: rat

Top Publications

  1. ncbi Transcription suppression of thromboxane receptor gene by peroxisome proliferator-activated receptor-gamma via an interaction with Sp1 in vascular smooth muscle cells
    Akira Sugawara
    Division of Nephrology, Department of Medicine, Tohoku University Graduate School of Medicine, 1 1 Seiryo cho, Aoba ku, Sendai 980 8574, Japan
    J Biol Chem 277:9676-83. 2002
  2. ncbi Expression of peroxisome proliferator-activated receptor isoform proteins in the rat kidney
    Kazunori Sato
    Department of Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan
    Hypertens Res 27:417-25. 2004
  3. doi PARP-1 suppresses adiponectin expression through poly(ADP-ribosyl)ation of PPAR gamma in cardiac fibroblasts
    Dan Huang
    Department of Cardiology, Institute of Cardiovascular Disease, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, People s Republic of China
    Cardiovasc Res 81:98-107. 2009
  4. ncbi Effects of mitogen-activated protein kinase pathway and co-activator CREP-binding protein on peroxisome proliferator-activated receptor-gamma-mediated transcription suppression of angiotensin II type 1 receptor gene
    Akira Sugawara
    Division of Nephrology, Endocrinology, and Vascular Medicine, Department of Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan
    Hypertens Res 26:623-8. 2003
  5. ncbi Diverse cardioprotective signaling mechanisms of peroxisome proliferator-activated receptor-gamma ligands, 15-deoxy-Delta12,14-prostaglandin J2 and ciglitazone, in reperfusion injury: role of nuclear factor-kappaB, heat shock factor 1, and Akt
    Basilia Zingarelli
    Division of Critical Care Medicine, Cincinnati Children s Hospital Medical Center, The University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA
    Shock 28:554-63. 2007
  6. ncbi Neuroprotective effects of prostaglandin A(1) in rat models of permanent focal cerebral ischemia are associated with nuclear factor-kappaB inhibition and peroxisome proliferator-activated receptor-gamma up-regulation
    Hui Ling Zhang
    Department of Pharmacology and Laboratory of Aging and Nervous Diseases, Soochow University School of Medicine, Suzhou, China
    J Neurosci Res 86:1132-41. 2008
  7. ncbi Inhibition of adipogenesis through MAP kinase-mediated phosphorylation of PPARgamma
    E Hu
    Dana Farber Cancer Institute and Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    Science 274:2100-3. 1996
  8. ncbi Transcriptional activation by peroxisome proliferator-activated receptor gamma is inhibited by phosphorylation at a consensus mitogen-activated protein kinase site
    M Adams
    Department of Medicine, University of Cambridge, Addenbrooke s Hospital, Cambridge CB2 2QQ, United Kingdom
    J Biol Chem 272:5128-32. 1997
  9. ncbi Obesity associated with a mutation in a genetic regulator of adipocyte differentiation
    M Ristow
    Joslin Diabetes Center and Harvard Medical School, Boston, MA 02215, USA
    N Engl J Med 339:953-9. 1998
  10. ncbi Peroxisome proliferator-activated receptor-gamma agonist troglitazone protects against nondiabetic glomerulosclerosis in rats
    L J Ma
    Department of Pathology and Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee 37232 2561, USA
    Kidney Int 59:1899-910. 2001

Research Grants

Detail Information

Publications161 found, 100 shown here

  1. ncbi Transcription suppression of thromboxane receptor gene by peroxisome proliferator-activated receptor-gamma via an interaction with Sp1 in vascular smooth muscle cells
    Akira Sugawara
    Division of Nephrology, Department of Medicine, Tohoku University Graduate School of Medicine, 1 1 Seiryo cho, Aoba ku, Sendai 980 8574, Japan
    J Biol Chem 277:9676-83. 2002
    ..In conclusion, PPAR-gamma suppresses TXR gene transcription via an interaction with Sp1. PPAR-gamma may possibly have an antiatherosclerotic action by inhibiting TXR gene expression in VSMCs...
  2. ncbi Expression of peroxisome proliferator-activated receptor isoform proteins in the rat kidney
    Kazunori Sato
    Department of Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan
    Hypertens Res 27:417-25. 2004
    ..Further studies will be needed to identify additional target genes for PPARs along the nephron segments...
  3. doi PARP-1 suppresses adiponectin expression through poly(ADP-ribosyl)ation of PPAR gamma in cardiac fibroblasts
    Dan Huang
    Department of Cardiology, Institute of Cardiovascular Disease, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, People s Republic of China
    Cardiovasc Res 81:98-107. 2009
    ..Our aim was to explore the mechanism underlying the transcriptional regulation of adiponectin and its receptors (AdipoR) in cultured rat cardiac fibroblasts...
  4. ncbi Effects of mitogen-activated protein kinase pathway and co-activator CREP-binding protein on peroxisome proliferator-activated receptor-gamma-mediated transcription suppression of angiotensin II type 1 receptor gene
    Akira Sugawara
    Division of Nephrology, Endocrinology, and Vascular Medicine, Department of Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan
    Hypertens Res 26:623-8. 2003
    ..The MAP kinase pathway and CBP may thus antagonize against PPAR-gamma in AT1R gene transcription, probably leading to the progression of atherosclerosis...
  5. ncbi Diverse cardioprotective signaling mechanisms of peroxisome proliferator-activated receptor-gamma ligands, 15-deoxy-Delta12,14-prostaglandin J2 and ciglitazone, in reperfusion injury: role of nuclear factor-kappaB, heat shock factor 1, and Akt
    Basilia Zingarelli
    Division of Critical Care Medicine, Cincinnati Children s Hospital Medical Center, The University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA
    Shock 28:554-63. 2007
    ..In contrast, GW-9662 did not affect the beneficial effects afforded by 15d-PGJ2. Thus, our data suggest that treatment with these chemically unrelated PPAR-gamma ligands results in diverse anti-inflammatory mechanisms...
  6. ncbi Neuroprotective effects of prostaglandin A(1) in rat models of permanent focal cerebral ischemia are associated with nuclear factor-kappaB inhibition and peroxisome proliferator-activated receptor-gamma up-regulation
    Hui Ling Zhang
    Department of Pharmacology and Laboratory of Aging and Nervous Diseases, Soochow University School of Medicine, Suzhou, China
    J Neurosci Res 86:1132-41. 2008
    ..These findings suggest that PGA(1)-mediated neuroprotective effect against ischemia appears to be associated with blocking NF-kappaB activation and likely with up-regulating PPAR-gamma expression...
  7. ncbi Inhibition of adipogenesis through MAP kinase-mediated phosphorylation of PPARgamma
    E Hu
    Dana Farber Cancer Institute and Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    Science 274:2100-3. 1996
    ..These results indicate that covalent modification of PPARgamma by serum and growth factors is a major regulator of the balance between cell growth and differentiation in the adipose cell lineage...
  8. ncbi Transcriptional activation by peroxisome proliferator-activated receptor gamma is inhibited by phosphorylation at a consensus mitogen-activated protein kinase site
    M Adams
    Department of Medicine, University of Cambridge, Addenbrooke s Hospital, Cambridge CB2 2QQ, United Kingdom
    J Biol Chem 272:5128-32. 1997
    ..This observation provides a potential mechanism whereby transcriptional activation by PPARgamma may be modulated by growth factor or cytokine-stimulated signal transduction pathways involved in adipogenesis...
  9. ncbi Obesity associated with a mutation in a genetic regulator of adipocyte differentiation
    M Ristow
    Joslin Diabetes Center and Harvard Medical School, Boston, MA 02215, USA
    N Engl J Med 339:953-9. 1998
    ..Peroxisome-proliferator-activated receptor gamma2 (PPARgamma2) is a transcription factor that has a key role in adipocyte differentiation, and therefore mutations of the gene for this factor might predispose people to obesity...
  10. ncbi Peroxisome proliferator-activated receptor-gamma agonist troglitazone protects against nondiabetic glomerulosclerosis in rats
    L J Ma
    Department of Pathology and Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee 37232 2561, USA
    Kidney Int 59:1899-910. 2001
    Peroxisome proliferator-activated receptor-gamma (PPAR gamma) is a member of the nuclear receptor superfamily of ligand-dependent transcriptional factors with beneficial effects in diabetes mediated by improved insulin sensitivity and ..
  11. ncbi Rat PPARs: quantitative analysis in adult rat tissues and regulation in fasting and refeeding
    P Escher
    Institut de Biologie Animale, Universite de Lausanne, CH 1015 Lausanne, Switzerland
    Endocrinology 142:4195-202. 2001
    ..Finally, PPAR gamma 2 mRNA levels are decreased by 50% during fasting in both white and brown adipose tissue...
  12. ncbi Identification of a functional peroxisome proliferator-activated receptor response element in the rat catalase promoter
    Geoffrey D Girnun
    Free Radical and Radiation Biology Program, University of Iowa, Iowa City, IA 52242, USA
    Mol Endocrinol 16:2793-801. 2002
    ..Thus, in addition to transrepression of proinflammatory transcription factors, PPARgamma may also be modulating catalase expression, and hence down-regulating the inflammatory response via scavenging of reactive oxygen species...
  13. ncbi Differential influences of peroxisome proliferator-activated receptors gamma and -alpha on food intake and energy homeostasis
    Philip J Larsen
    Rheoscience, Rødovre, Denmark
    Diabetes 52:2249-59. 2003
    ..In a chronic-dosing study, equiefficacious antihyperglycemic doses of the PPAR gamma agonist pioglitazone and PPAR alpha/gamma dual activator ragaglitazar were administered to obesity-prone male ..
  14. ncbi PPAR-gamma overexpression selectively suppresses insulin secretory capacity in isolated pancreatic islets through induction of UCP-2 protein
    Eisuke Ito
    Third Department of Internal Medicine, Kyorin University School of Medicine, 6 20 2 Shinkawa, Mitaka, Tokyo 181 8611, Japan
    Biochem Biophys Res Commun 324:810-4. 2004
    ..And it is possible that its site of action can be located in the energy-consuming exocytotic process of insulin secretory granules, and that the reduction of ATP production through increased UCP-2 reduces insulin exocytosis...
  15. ncbi Study of peroxisome proliferator-activated receptor (PPAR)-gamma in renal ischemia-reperfusion injury
    R Yoshimura
    Department of Urology, Osaka University Graduate School of Medicine, Osaka, Japan
    Transplant Proc 36:1946-8. 2004
    ..Several hours after maximal of PPAR-gamma expression, maximal renal I/R injury was observed. These results may indicate a relationship between PPAR-gamma expression and renal I/R injury...
  16. ncbi Effect of PPAR-gamma activation and inhibition on glucose-stimulated insulin release in INS-1e cells
    Eleonora Santini
    Department of Internal Medicine, Via Roma, 67, 56100, Pisa, Italy
    Diabetes 53:S79-83. 2004
    ..0001 for both effects). In conclusion, INS-1e cells display a PPAR-gamma tone that is symmetrically modulated and competitively stimulated by oleate...
  17. ncbi A peroxisome proliferator-activated receptor-gamma agonist reduces infarct size in transient but not in permanent ischemia
    Tomokazu Shimazu
    Cerebrovascular Research Center, Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia 19104 6063, USA
    Stroke 36:353-9. 2005
    ..These properties raise the question of whether a PPARgamma agonist may be neuroprotective in models of ischemia without reperfusion, in which oxidative injury is less prevalent...
  18. ncbi Peroxisome proliferator-activated receptor gamma is a novel target of the nerve growth factor signaling pathway in PC12 cells
    Karen M Fuenzalida
    Centro de Regulación Celular y Patología and Millennium Institute for Fundamental and Applied Biology, Faculty of Biological Sciences, P Universidad Catolica de Chile, Casilla 114 D, Santiago, Chile
    J Biol Chem 280:9604-9. 2005
    ....
  19. ncbi The peroxisome proliferator-activated receptor gamma ligand troglitazone induces apoptosis and p53 in rat granulosa cells
    Tara Lovekamp-Swan
    Medical College of Georgia, Department of Physiology, 1120 15th Street, Augusta, GA 30912, USA
    Mol Cell Endocrinol 233:15-24. 2005
    ..These data indicate that PPARgamma is in the ovary is capable of binding DNA in the absence of pharmacological activation and provide evidence for a possible physiologic role for this receptor in regulating granulosa cell survival...
  20. ncbi Peroxisome proliferator-activated receptor alpha (PPARalpha) potentiates, whereas PPARgamma attenuates, glucose-stimulated insulin secretion in pancreatic beta-cells
    Kim Ravnskjaer
    Department of Biochemistry and Molecular Biology University of Southern Denmark, Campusvej 55, 5230 Odense M, Denmark
    Endocrinology 146:3266-76. 2005
    ..These results show a strong subtype specificity of the two PPAR subtypes alpha and gamma on lipid partitioning and insulin secretion when systematically compared in a beta-cell context...
  21. ncbi PPARgamma agonists diminish serum VEGF elevation in diet-induced insulin resistant SD rats and ZDF rats
    Baichun Yang
    Department of Molecular Pharmacology, GlaxoSmithKline, Research Triangle Park, NC 27709, USA
    Biochem Biophys Res Commun 334:176-82. 2005
    ....
  22. ncbi Tesaglitazar, a dual PPAR{alpha}/{gamma} agonist, ameliorates glucose and lipid intolerance in obese Zucker rats
    Nicholas D Oakes
    AstraZeneca R and D Molndal, S 431 83 Molndal, Sweden
    Am J Physiol Regul Integr Comp Physiol 289:R938-46. 2005
    ..The present work demonstrates that tesaglitazar ameliorates these abnormalities and enhances insulin sensitivity in this animal model...
  23. ncbi Modulation of cardiac and aortic peroxisome proliferator-activated receptor-gamma expression by oxidative stress in chronically glucose-fed rats
    Adil El Midaoui
    Department of Physiology, Faculty of Medecine, University of Montreal, Montreal, Quebec, Canada
    Am J Hypertens 19:407-12. 2006
    ..We have also evaluated the chronic effects of high levels of insulin, glucose, or both on superoxide anion (O(2)(-)) production in aortic smooth muscle cells (SMCs) in the presence or in absence of pioglitazone, a PPAR-gamma agonist...
  24. ncbi Effects of peroxisome proliferator-activated receptor gamma and its ligand on blood-retinal barrier in a streptozotocin-induced diabetic model
    Kimimasa Muranaka
    Department of Ophthalmology, University of Tokyo School of Medicine, Tokyo, Japan
    Invest Ophthalmol Vis Sci 47:4547-52. 2006
    ..To clarify whether endogenous peroxisome proliferator-activated receptor gamma (PPARgamma) and its ligand, rosiglitazone, affect retinal leukostasis and the associated vascular leakage using an experimental diabetic model...
  25. pmc Induction of PPAR gamma mRNA and protein expression by rosiglitazone in chronic cyclosporine nephropathy in the rat
    Kyung Ohk Ahn
    Department of Internal Medicine, Kangnam St Mary s Hospital, 505 Banpo Dong, Seocho Gu, Seoul, Korea
    Yonsei Med J 48:308-16. 2007
    ..Here we report the effect of RGTZ on peroxisome proliferator-activated receptor gamma (PPARgamma) expression in an experimental model of chronic cyclosporine (CsA) nephropathy...
  26. ncbi Effect of overexpression of PPARgamma on the healing process of corneal alkali burn in mice
    Shizuya Saika
    Dept of Ophthalmology, Wakayama Medical University, 811 1 Kimiidera, Wakayama, 641 0012, Japan
    Am J Physiol Cell Physiol 293:C75-86. 2007
    ..Together, these data suggest that overexpression of PPARgamma may represent an effective new strategy for treatment of ocular surface burns...
  27. pmc The PPARgamma-selective ligand BRL-49653 differentially regulates the fate choices of rat calvaria versus rat bone marrow stromal cell populations
    Takuro Hasegawa
    1Department of Orthodontics, Hiroshima University Graduate School of Biomedical Sciences, 1 2 3 Kasumi, Minami Ku, Hiroshima 734 8553, Japan
    BMC Dev Biol 8:71. 2008
    ....
  28. pmc Expression of peroxisome proliferator-activated receptor-gamma in key neuronal subsets regulating glucose metabolism and energy homeostasis
    David A Sarruf
    Department of Medicine, Diabetes and Obesity Center of Excellence, University of Washington, Seattle, WA 98195, USA
    Endocrinology 150:707-12. 2009
    ....
  29. pmc Characterization of a novel polymorphism in PPARG regulatory region associated with type 2 diabetes and diabetic retinopathy in Italy
    Valerio Costa
    Institute of Genetics and Biophysics A Buzzati Traverso IGB, National Research Council CNR, Naples, Italy
    J Biomed Biotechnol 2009:126917. 2009
    ..In the analyzed population, this variant represents a genetic risk factor for developing the diabetic retinopathy, whereas Pro12Ala and C1431T do not...
  30. doi PPARgamma transcriptionally regulates the expression of insulin-degrading enzyme in primary neurons
    Jing Du
    Protein Science Key Laboratory of the Ministry of Education, Department of Biological Sciences and Biotechnology, School of Medicine, Tsinghua University, Beijing 100084, PR China
    Biochem Biophys Res Commun 383:485-90. 2009
    ..These results suggest that PPARgamma transcriptionally induces IDE expression which provides a novel mechanism for the use of PPARgamma agonists in both DM2 and AD therapies...
  31. ncbi Peroxisome proliferator-activated receptor-gamma and retinoid X receptor-alpha expression in pancreatic ductal adenocarcinoma: association with clinicopathological parameters, tumor proliferative capacity, and patients' survival
    Constantinos Giaginis
    Department of Forensic Medicine and Toxicology, University of Athens, Athens, Greece
    Med Sci Monit 15:BR148-56. 2009
    ..The aim of the present study was to evaluate the clinical significance of PPAR-gamma and RXR-alpha expression in pancreatic adenocarcinoma...
  32. pmc PPARgamma activation in adipocytes is sufficient for systemic insulin sensitization
    Shigeki Sugii
    Gene Expression Laboratory, Howard Hughes Medical Institute and The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 106:22504-9. 2009
    ....
  33. doi Positive correlation between PPARgamma/PGC-1alpha and gamma-GCS in lungs of rats and patients with chronic obstructive pulmonary disease
    Jie Li
    Department of Respiratory Medicine, Hunan Institute of Gerontology, Hunan Province Geriatric Hospital, Changsha, China
    Acta Biochim Biophys Sin (Shanghai) 42:603-14. 2010
    ..The activation of the PPARgamma/PGC-1alpha pathway may protect against COPD progression by upregulating gamma-GCS and relieving oxidative stress...
  34. doi Rosiglitazone, a PPAR-γ agonist, protects against striatal dopaminergic neurodegeneration induced by 6-OHDA lesions in the substantia nigra of rats
    Eun Young Lee
    Department of Pharmacology, College of Medicine, Hanyang University, 133 791 Seoul, Republic of Korea
    Toxicol Lett 213:332-44. 2012
    ..Our results provide insight into the neuroprotective mechanisms of rosiglitazone against 6-OHDA-induced neuronal damages...
  35. doi Aging alters PPARgamma in rodent and human adipose tissue by modulating the balance in steroid receptor coactivator-1
    Stephanie Miard
    Laval Hospital Research Center, Laval University, Quebec, QC, Canada
    Aging Cell 8:449-59. 2009
    ..These findings suggest that strategies aimed at increasing SRC-1 expression and recruitment to PPARgamma upon aging might help improve age-associated metabolic disorders...
  36. ncbi Pro12Ala missense mutation of the peroxisome proliferator activated receptor gamma and diabetes mellitus
    J Ringel
    Department of Internal Medicine, Division of Endocrinology and Nephrology, Universitatsklinikum Benjamin Franklin, Free University of Berlin, Berlin, Federal Republic of Germany
    Biochem Biophys Res Commun 254:450-3. 1999
    ..This genetic marker is therefore unlikely to serve as a clinically useful predictor of these disorders in Caucasian patients with diabetes mellitus...
  37. ncbi Unique ability of troglitazone to up-regulate peroxisome proliferator-activated receptor-gamma expression in hepatocytes
    Gerald F Davies
    Department of Biochemistry, University of Saskatchewan, Saskatoon, Saskatchewan, Canada
    J Pharmacol Exp Ther 300:72-7. 2002
    ..These data indicate that 1) up-regulation of the transactivation function of PPAR-gamma does not alone account for the induction of expression of PPAR-gamma by troglitazone, and 2) an antioxidant-related mechanism may be involved...
  38. ncbi PPAR-gamma activation mediates adipose depot-specific effects on gene expression and lipoprotein lipase activity: mechanisms for modulation of postprandial lipemia and differential adipose accretion
    Mathieu Laplante
    Department of Anatomy and Physiology, Laval Hospital Research Center, School of Medicine, Laval University, Quebec, Canada
    Diabetes 52:291-9. 2003
    ..These depot-specific effects may be mediated by differential regulation of key metabolic genes, including LPL, 11beta-HSD-1, and UCP-1...
  39. ncbi Circulating activators of peroxisome proliferator-activated receptors are reduced in preeclamptic pregnancy
    Leslie L Waite
    Center for Reproductive Sciences, University of California San Francisc, CA 94143, USA
    J Clin Endocrinol Metab 90:620-6. 2005
    We previously described activators of peroxisome proliferator-activated receptor gamma (PPAR gamma) in the serum of pregnant women...
  40. ncbi Peroxisome proliferator-activated receptor gamma promotes epithelial to mesenchymal transformation by Rho GTPase-dependent activation of ERK1/2
    Lu Chen
    Department of Cancer Biology, Mayo Clinic Comprehensive Cancer Center, Jacksonville, Florida 32224, USA
    J Biol Chem 281:24575-87. 2006
    ....
  41. doi Peroxisome proliferator-activated receptor-gamma gene polymorphism and risk of cardiovascular disease in patients with diabetic nephropathy
    Cheuk Chun Szeto
    Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, SAR, China
    Am J Nephrol 28:715-22. 2008
    ..We examined the relationship between two PPAR-gamma gene polymorphisms, namely the P12A and C161T, and cardiovascular disease in patients with diabetic nephropathy...
  42. ncbi Chronic effects of berberine on blood, liver glucolipid metabolism and liver PPARs expression in diabetic hyperlipidemic rats
    Ji Yin Zhou
    Base for Drug Clinical Trial, Xinqiao Hospital, Third Military Medical University, Chongqing, China
    Biol Pharm Bull 31:1169-76. 2008
    ..Berberine improved glucolipid metabolism both in blood and liver in diabetic rats possibly through modulating the metabolic related PPARalpha/delta/gamma protein expression in liver...
  43. doi Effect of fasting on PPARgamma and AMPK activity in adipocytes
    Kazuo Kajita
    Department of General Internal Medicine, Gifu University Graduate School of Medicine, Yanagido 1 1, Gifu 501 1194, Japan
    Diabetes Res Clin Pract 81:144-9. 2008
    ..AICAR reduced PPARgamma mRNA levels but increased aP2 and LPL mRNA levels. Thus, fasting-induced AMPK activation may affect on the regulation of gene expression in adipocytes...
  44. doi Osthole regulates enzyme protein expression of CYP7A1 and DGAT2 via activation of PPARalpha/gamma in fat milk-induced fatty liver rats
    Yan Zhang
    Department of Pharmacology, Medical School of Soochow University, Suzhou, China
    J Asian Nat Prod Res 10:807-12. 2008
    ....
  45. doi Early and prolonged intake of partially hydrogenated fat alters the expression of genes in rat adipose tissue
    Daniella E Duque-Guimarães
    Institute of Nutrition, Federal University of Rio de Janeiro, Brazil
    Nutrition 25:782-9. 2009
    ..In the present study we investigated the effects of dietary PHF on the expression of genes associated with glucose and lipid metabolism in rat adipose tissue...
  46. doi Effect of a peroxisome proliferator-activated receptor gamma sumoylation mutant on neointimal formation after balloon injury in rats
    Soo Lim
    Department of Internal Medicine, Seoul National University College of Medicine, 28 Yongon Dong, Chongno Gu, 110 744 Seoul, South Korea
    Atherosclerosis 206:411-7. 2009
    ..These results indicate that desumoylation at K107 in PPARgamma might play an important role against atherosclerosis...
  47. pmc Vascular smooth muscle cell peroxisome proliferator-activated receptor-γ deletion promotes abdominal aortic aneurysms
    Milton Hamblin
    Cardiovascular Center, Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, Mich, USA
    J Vasc Surg 52:984-93. 2010
    ..We hypothesized that PPARγ in smooth muscle cells (SMCs) attenuates the development of AAA. We also investigated PPARγ-mediated signaling pathways that may prevent the development of AAA...
  48. pmc Decreased hepatic peroxisome proliferator-activated receptor-γ contributes to increased sensitivity to endotoxin in obstructive jaundice
    Xin Lv
    Department of Anesthesiology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China
    World J Gastroenterol 17:5267-73. 2011
    ..To investigate the role of hepatic peroxisome proliferator-activated receptor-γ (PPAR-γ) in increased susceptibility to endotoxin-induced toxicity in rats with bile duct ligation during endotoxemia...
  49. doi Activation of PPARδ up-regulates the expression of insulin gene transcription factor MafA and ameliorates glucose-induced insulin secretion impaired by palmitate
    Mingming Cao
    Division of Endocrinology, West China Hospital of Sichuan University, 37 Guoxuexiang, Chengdu 610041, Sichuan, China
    Mol Cell Biochem 366:183-9. 2012
    ..Collectively, these results demonstrate that activation of PPARδ improves insulin secretion impaired by palmitate and plays a role in the JNK-MafA-GLUT2 pathway...
  50. doi β-Catenin pathway is required for TGF-β1 inhibition of PPARγ expression in cultured hepatic stellate cells
    Jingjing Qian
    Affiliated Hospital of Nantong University, Qi Xiou Road 19, Nantong 226001, Jiangsu, China
    Pharmacol Res 66:219-25. 2012
    ..These results indicated for the first time that TGF-β1 could down-regulate PPARγ expression through β-catenin pathway and subsequently contributed to the increase in alpha1(1) collagen level in cultured HSCs...
  51. pmc Peroxisome proliferator-activated receptors γ/mitochondrial uncoupling protein 2 signaling protects against seizure-induced neuronal cell death in the hippocampus following experimental status epilepticus
    Yao Chung Chuang
    Department of Neurology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 83301, Taiwan
    J Neuroinflammation 9:184. 2012
    ..We evaluated the neuroprotective role of UCP2 against seizure-induced hippocampal neuronal cell death under experimental status epilepticus...
  52. pmc mTOR regulates fatty infiltration through SREBP-1 and PPARγ after a combined massive rotator cuff tear and suprascapular nerve injury in rats
    Sunil K Joshi
    San Francisco Veterans Affairs Medical Center, Department of Veterans Affairs, University of California, 1500 Owens Avenue, San Francisco, CA 94153, USA
    J Orthop Res 31:724-30. 2013
    ..Therefore, our study suggests that mTOR signaling mediates rotator cuff fatty infiltration via SREBP-1 and PPARγ. Clinically, our finding may alter current treatment methods to address rotator cuff fatty infiltration...
  53. ncbi PPARγ activation improves the molecular and functional components of I(to) remodeling by angiotensin II
    Gayani Nanayakkara
    Department of Pharmacal Sciences, PPAR and Metabolic Research Lab, Auburn University, Auburn, Alabama 36849, USA
    Curr Pharm Des 19:4839-47. 2013
    ..These findings demonstrate that PPARγ agonists have the potential to attenuate cardiomyocyte dysfunction associated with diabetes...
  54. doi Involvement of peroxisome proliferator-activated receptor gamma in vitamin D-mediated protection against acute kidney injury in rats
    Akanksha Kapil
    Department of Pharmaceutical Sciences, Guru Nanak Dev University, Amritsar, India
    J Surg Res 185:774-83. 2013
    ..The present study investigated the activation of PPAR-γ as novel mechanism in vitamin D-mediated protection against ischemia reperfusion-induced acute kidney injury (AKI) in rats...
  55. doi Glycyrrhizin Attenuates Proinflammatory Cytokines through a Peroxisome Proliferator-Activated Receptor-γ-Dependent Mechanism and Experimental Vasospasm in a Rat Model
    Chih Zen Chang
    Department of Surgery, Faculty of Medicine, School of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan, ROC
    J Vasc Res 52:12-21. 2015
    ..These findings also offer credit to the antivasospastic effect of glycyrrhizin and its vasculoprotective effect in animals subjected to SAH...
  56. pmc Mutual induction of transcription factor PPARγ and microRNAs miR-145 and miR-329
    Ashutosh Dharap
    Department of Neurological Surgery and Neuroscience Training Program, University of Wisconsin, Madison, Wisconsin, USA
    J Neurochem 135:139-46. 2015
    ..Two such PPARγ-responsive microRNAs (miR-145 and miR-329) bind to PPARγ promoter to induce its expression. This indicates the presence of a feedback loop by which transcription factors and microRNAs can modulate each other. ..
  57. doi Nurr1 and PPARγ protect PC12 cells against MPP(+) toxicity: involvement of selective genes, anti-inflammatory, ROS generation, and antimitochondrial impairment
    Mohammad Jodeiri Farshbaf
    Department of Biology, School of Sciences, University of Isfahan, Isfahan, 81746 73441, Iran
    Mol Cell Biochem 420:29-42. 2016
    ..Moreover, production of intracellular ROS and MMP modulated by MPP(+) was decreased by PPARγ and Nurr1 agonists' treatment alone and in the combined form. ..
  58. ncbi Role of adipogenic and thermogenic genes in susceptibility or resistance to develop diet-induced obesity in rats
    N Pérez-Echarri
    Departament of Nutrition, Food Science, Physiology and Toxicology, University of Navarra, 31008 Pamplona, Spain
    J Physiol Biochem 63:317-27. 2007
    ..The compensatory adaptations through the increase in energy expenditure by changes on the expression levels of UCP1 seem not to be enough to avoid the obesity onset in the DIO group...
  59. pmc Knockdown of the gene encoding Drosophila tribbles homologue 3 (Trib3) improves insulin sensitivity through peroxisome proliferator-activated receptor-γ (PPAR-γ) activation in a rat model of insulin resistance
    D Weismann
    Section of Endocrinology, Department of Internal Medicine, Yale University School of Medicine, PO Box 802010, New Haven, CT 06520 8020, USA
    Diabetologia 54:935-44. 2011
    ..However, the physiological impact of TRIB3 action in vivo remains controversial...
  60. ncbi [Effect of pioglitazone on hypoxia/reoxygenation injury and protein kinase C expression in neonatal rat cardiomyocytes]
    Qi Wei Zhu
    Second Department of Geriatric Cardiology, General Hospital of PLA, Beijing 100853, China
    Nan Fang Yi Ke Da Xue Xue Bao 31:1819-23. 2011
    ..To observe the effect of pioglitazone on hypoxia/reoxygenation injury and the expression of protein kinase C (PKC) in neonatal rat cardiomyocytes...
  61. doi Peroxisome proliferator-activated receptor-γ ameliorates pulmonary arterial hypertension by inhibiting 5-hydroxytryptamine 2B receptor
    Yahan Liu
    Institute of Cardiovascular Science, Peking University, Beijing 100191, China
    Hypertension 60:1471-8. 2012
    ..These results demonstrated the beneficial effect of PPARγ on 5-HT2BR-mediated vasocontraction, providing a new mechanism for the potential use of PPARγ agonists in PAH...
  62. pmc PPAR-γ activation increases insulin secretion through the up-regulation of the free fatty acid receptor GPR40 in pancreatic β-cells
    Hyo Sup Kim
    Division of Endocrinology and Metabolism, Samsung Biomedical Research Institute, Sungkyunkwan University School of Medicine, Seoul, Korea
    PLoS ONE 8:e50128. 2013
    ..We investigated whether PPAR-γ activation stimulates insulin secretion through the up-regulation of GPR40 in pancreatic β-cells...
  63. doi The intrinsic PEDF is regulated by PPARγ in permanent focal cerebral ischemia of rat
    Chunhua Zhu
    Department of Neurology, Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, People s Republic of China
    Neurochem Res 37:2099-107. 2012
    ..05). The expression of intrinsic PEDF was down-regulated at the early stage of cerebral ischemia. The protective effects of intrinsic PEDF by activating PPARγ pathway may be one of the strategic targets for cerebral ischemic therapies...
  64. ncbi Genetic variation in PPARG encoding peroxisome proliferator-activated receptor gamma associated with carotid atherosclerosis
    Khalid Z Al-Shali
    Robarts Research Institute, London, Ontario, Canada
    Stroke 35:2036-40. 2004
    ..Genetic variation in PPARG has been associated with metabolic and cardiovascular end points...
  65. ncbi Changes in expression levels of genes involved in fatty acid metabolism: upregulation of all three members of the PPAR family (alpha, gamma, delta) and the newly described adiponectin receptor 2, but not adiponectin receptor 1 during neonatal cardiac deve
    Michael Steinmetz
    Department of Pediatric Cardiology and Intensive Care Medicine, Georg August University Gottingen, Robert Koch Str 40, 37075 Gottingen, Germany
    Basic Res Cardiol 100:263-9. 2005
    ..The aim of this study was to investigate the changes in mRNA expression levels of genes involved in the control of cardiac fatty acid metabolism in the transition from neonatal to adult life...
  66. doi Activation of peroxisome proliferator-activated receptor gamma inhibits endothelin-1-induced cardiac hypertrophy via the calcineurin/NFAT signaling pathway
    Yingxia Bao
    Laboratory of Pharmacology and Toxicology, School of Pharmaceutical Sciences, Sun Yat Sen University, 74 Zhongshan II Road, Guangzhou, 510080, People s Republic of China
    Mol Cell Biochem 317:189-96. 2008
    ..These results suggest that ET-1-induced cardiac hypertrophy is inhibited by activation of PPAR-gamma, which is at least partly due to cross-talk between PPAR-gamma and calcineurin/NFAT...
  67. doi IL-13 downregulates PPAR-gamma/heme oxygenase-1 via ER stress-stimulated calpain activation: aggravation of activated microglia death
    Shing Hwa Liu
    Institute of Toxicology, College of Medicine, National Taiwan University, Taipei, Taiwan
    Cell Mol Life Sci 67:1465-76. 2010
    ..These results indicate that an ER stress-related calpain-down-regulated PPAR-gamma/HO-1 pathway is involved in the IL-13-enhanced activated death of microglia...
  68. doi The differential effects of aligned electrospun PHBHHx fibers on adipogenic and osteogenic potential of MSCs through the regulation of PPARγ signaling
    Yang Wang
    Ministry of Education Key Laboratory of Bioinformatics, School of Life Sciences, Tsinghua University, Beijing 100084, China
    Biomaterials 33:485-93. 2012
    ..However, the induction of osteogenic by PHBHHx fiber alignment was relatively less significant that it could only support initial adipo-osteogenic switch and would be partially covered up by osteogenic or adipogenic inductive chemicals...
  69. doi Geranylgeranyl pyrophosphate stimulates PPARγ expression and adipogenesis through the inhibition of osteoblast differentiation
    Megan M Weivoda
    Department of Pharmacology, 51 Newton Road, Iowa City, IA 52242, USA
    Bone 50:467-76. 2012
    ..Additionally, the effects of GGPP on insulin signaling suggest a potential mechanism for inhibition of osteoblast differentiation and also implicate a role for this isoprenoid in physiological energy homeostasis...
  70. doi The calcium-sensing receptor promotes adipocyte differentiation and adipogenesis through PPARγ pathway
    Yong Han He
    Department of Nutrition and Food Hygiene, Public Health College, Harbin Medical University, Nangang District, Harbin, China
    Mol Cell Biochem 361:321-8. 2012
    ..Therefore, CaSR in adipocytes may be involved in the pathogenesis of obesity by promoting adipocyte differentiation and adipogenesis...
  71. doi Improved insulin sensitivity after long-term treatment with AT1 blockers is not associated with PPARγ target gene regulation
    Helge Müller-Fielitz
    Institute of Experimental and Clinical Pharmacology and Toxicology, University of Lubeck, Ratzeburger Allee 160, 23538 Lubeck, Germany
    Endocrinology 153:1103-15. 2012
    ..Because the expression of examined PPARγ target genes was not affected, we concluded that improved insulin sensitivity after long-term treatment with AT(1) blockers was not related to a PPARγ-dependent mechanism...
  72. pmc Physiological responses to acute psychological stress are reduced by the PPARγ agonist rosiglitazone
    Karen K Ryan
    Department of Internal Medicine, Division of Endocrinology, Diabetes, and Metabolism, The University of Cincinnati College of Medicine, Cincinnati, Ohio 45237, USA
    Endocrinology 153:1279-87. 2012
    ..Taken as a whole, these data suggest that PPARγ stimulation potently inhibits physiological responses to psychological stress, prescribing a novel role for PPARγ signaling in the regulation of brain stress integration...
  73. ncbi Peroxisome proliferator-activated receptor agonists inhibit inflammatory edema and hyperalgesia
    Bradley K Taylor
    Division of Pharmacology, School of Pharmacy, University of Missouri Kansas City, 64108, USA
    Inflammation 26:121-7. 2002
    ..We conclude that systemic administration of potent PPARalpha and PPARgamma agonists exert anti-hyperalgesic and/or antiinflammatory actions in vivo, possibly by interfering with the initiation of inflammation...
  74. ncbi PPARgamma inhibition of cyclooxygenase-2, PGE2 synthase, and inducible nitric oxide synthase in cardiac myocytes
    Mariela Mendez
    Hypertension and Vascular Research Division, Henry Ford Hospital, 2799 West Grand Blvd, Detroit, MI 48202 2689, USA
    Hypertension 42:844-50. 2003
    ..We concluded that 15dPGJ2 may play an anti-inflammatory role in a PPARgamma-dependent manner, decreasing COX-2, PGES, and PGE2 production, as well as iNOS expression...
  75. ncbi 17beta-estradiol upregulates the expression of peroxisome proliferator-activated receptor alpha and lipid oxidative genes in skeletal muscle
    S E Campbell
    Department of Physiology, University of Melbourne, Parkville, Victoria 3010, Australia
    J Mol Endocrinol 31:37-45. 2003
    ..05) by E(2) treatment, although protein content remained unaltered. These data demonstrate the novel regulation of E(2) on PPARalpha and genes encoding key proteins that are pivotal in regulating skeletal muscle lipid oxidative flux...
  76. ncbi NF-kappa B-binding activity in an animal diet-induced overweightness model and the impact of subsequent energy restriction
    O Lamas
    Department of Physiology and Nutrition, University of Navarra, 31008 Pamplona, Navarre, Spain
    Biochem Biophys Res Commun 311:533-9. 2003
    ..The purpose of this work was to analyse the hypothesis that PPAR gamma 1 participates in the inhibition of the immune response by affecting the DNA-binding ability of the NF-kappa B ..
  77. ncbi 15-Deoxy-delta(12,14)-prostaglandin J(2) inhibits IL-1beta-induced IKK enzymatic activity and IkappaBalpha degradation in rat chondrocytes through a PPARgamma-independent pathway
    Sandrine Boyault
    Laboratoire de Pharmacologie, UMR 7561 CNRS Université, Henri Poincaré Nancy I, Faculte de Medecine, 54505 Vandoeuvre les Nancy, France
    FEBS Lett 572:33-40. 2004
    ..These results suggest that 15d-PGJ(2) exerts its anti-inflammatory effect in rat chondrocytes by a PPARgamma-independent mechanism, which can be conferred to a partial inhibition of IkappaBalpha degradation...
  78. ncbi Basic fibroblast growth factor enhances PPARgamma ligand-induced adipogenesis of mesenchymal stem cells
    Markus Neubauer
    Department of Pharmaceutical Technology, University of Regensburg, Universitaetsstrasse 31, D 93040 Regensburg, Germany
    FEBS Lett 577:277-83. 2004
    ..Basic FGF was demonstrated to also strongly increase adipogenesis induced by troglitazone, that is, bFGF clearly increased the responsiveness of MSCs to a PPARgamma ligand...
  79. ncbi TNFalpha reduces the expression of peroxisome proliferator-activated receptor gamma (PPARgamma) via the production of ceramide and activation of atypical PKC
    Kazuo Kajita
    Department of General Internal Medicine, Gifu University School of Medicine, Yanagido 1 1, Gifu 501 1194, Japan
    Diabetes Res Clin Pract 66:S79-83. 2004
    ..8%. These results indicate that the reducing effect of TNFalpha is mediated through ceramide, atypical PKC and NF-kappaB pathway...
  80. ncbi Peroxisome proliferator-activated receptor gamma-independent activation of p38 MAPK by thiazolidinediones involves calcium/calmodulin-dependent protein kinase II and protein kinase R: correlation with endoplasmic reticulum stress
    Olivia S Gardner
    Curriculum in Toxicology, University of North Carolina at Chapel Hill, North Carolina, 27599, USA
    J Biol Chem 280:10109-18. 2005
    ..Furthermore, using structural derivatives of TZDs that lack PPARgamma ligand-binding activity as well as a PPARgamma antagonist, we show that activation of these kinase signaling pathways is PPARgamma-independent...
  81. ncbi Enterostatin decreases postprandial pancreatic UCP2 mRNA levels and increases plasma insulin and amylin
    Denis Arsenijevic
    Institute of Animal Sciences, Eidegnossische Technische Hochschule Zurich, Schwerzenbach, Switzerland
    Am J Physiol Endocrinol Metab 289:E40-5. 2005
    ..This implies that enterostatin changes lipid and carbohydrate metabolic pathways in addition to its effects on food intake and energy expenditure...
  82. ncbi Free fatty acids repress the GLUT4 gene expression in cardiac muscle via novel response elements
    Michal Armoni
    Institute of Endocrinology, Diabetes and Metabolism, Rambam Medical Center and B Rappaport Faculty of Medicine, Technion Israel Institute of Technology, Haifa 31096, Israel
    J Biol Chem 280:34786-95. 2005
    ....
  83. ncbi Peroxisome proliferator-activated receptor gamma overexpression inhibits pro-fibrogenic activities of immortalised rat pancreatic stellate cells
    Robert Jaster
    Department of Medicine, Division of Gastroenterology, Medical Faculty, University of Rostock, Rostock, 18057, Germany
    J Cell Mol Med 9:670-82. 2005
    ..In conclusion, our data suggest an active role of PPARgamma in the induction of a quiescent PSC phenotype. PPARgamma-regulated genes in PSCs may serve as novel targets for the development of antifibrotic therapies...
  84. ncbi [Expression of peroxisome proliferators-activated receptor gamma and alpha-smooth muscle actin in unilateral ureteral obstruction in rats]
    Xiao Yang
    Department of Nephrology, First Affiliated Hospital, Sun Yat Sen University, Guangzhou 510080, Guangdong, China
    Zhongguo Wei Zhong Bing Ji Jiu Yi Xue 17:611-4. 2005
    To evaluate the expression of peroxisome proliferators-activated receptor gamma (PPAR gamma) and alpha-smooth muscle actin (alpha-SMA) in unilateral ureteral obstruction (UUO) in rats and the relationship between them and the extent of ..
  85. ncbi [UCPs and PPARgamma2 mRNA in diet induced obesity resistant rats]
    Nian Hong Yang
    Department of Nutrition and Food Hygiene, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
    Wei Sheng Yan Jiu 34:556-8. 2005
    ..To explore the expression of uncoupling proteins (UCP) and peroxisome proliferator activated receptorgamma2 (PPARgamma2) mRNA in white adipose of high-fat diet induced obesity resistant rats...
  86. ncbi PRIC320, a transcription coactivator, isolated from peroxisome proliferator-binding protein complex
    Sailesh Surapureddi
    The Department of Pathology, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611, USA
    Biochem Biophys Res Commun 343:535-43. 2006
    ..We conclude that ciprofibrate, a PPARalpha ligand, binds a multiprotein complex and PRIC320 cloned from this complex functions as a nuclear receptor coactivator...
  87. ncbi FOXO1 represses peroxisome proliferator-activated receptor-gamma1 and -gamma2 gene promoters in primary adipocytes. A novel paradigm to increase insulin sensitivity
    Michal Armoni
    Institute of Endocrinology, Diabetes and Metabolism, Rambam Medical Center, Haifa, Israel
    J Biol Chem 281:19881-91. 2006
    ..The newly identified FOXO1-binding site on the PPARgamma2 promoter may serve as a therapeutic target for type 2 diabetes...
  88. ncbi Involvement of adipose tissues in the early hypolipidemic action of PPARgamma agonism in the rat
    Mathieu Laplante
    Laval Hospital Research Center, Laval Hospital d Youville Y3110, 2725 Chemin Sainte Foy, Quebec, QC, Canada, G1V 4G5
    Am J Physiol Regul Integr Comp Physiol 292:R1408-17. 2007
    ....
  89. ncbi PPARgamma inhibits osteogenesis via the down-regulation of the expression of COX-2 and iNOS in rats
    Tzu Hung Lin
    Department of Pharmacology, College of Medicine, National Taiwan University, Taipei, Taiwan
    Bone 41:562-74. 2007
    ..These data may reflect osteoporosis and less bone formation in the aging people and patients treated with thiazolidinediones...
  90. ncbi [PPARgamma and C/EBPalpha mRNA expression in the primary culture of rat preadipocytes during differentiation]
    Sheng Feng Chen
    College of Animal Science, South China Agricultural University, Guangzhou 510642
    Fen Zi Xi Bao Sheng Wu Xue Bao 40:272-5. 2007
    ..In a conclusion, this study suggested that both the initiating and maintaining of differentiation process were regulated by PPARgamma, while C/EBPalpha was likely to participate in the maintaining of differentiation process only...
  91. ncbi Downregulation of PPARs and SREBP by acyl-CoA-binding protein overexpression in transgenic rats
    Sanna Oikari
    Department of Biotechnology and Molecular Medicine, A I Virtanen Institute, University of Kuopio, P O Box 1627, 70211 Kuopio, Finland
    Pflugers Arch 456:369-77. 2008
    ..ACBP itself is a target gene for both transcription factors demonstrating important feedback loops...
  92. doi Suppression of cardiac myocyte hypertrophy by conjugated linoleic acid: role of peroxisome proliferator-activated receptors alpha and gamma
    Caroline P Alibin
    Faculty of Pharmacy, University of Manitoba and the Canadian Centre for Agri Food Research in Health and Medicine, St Boniface General Hospital Research Centre, Winnipeg, Manitoba R2H 2A6, Canada
    J Biol Chem 283:10707-15. 2008
    ..These data suggest that dietary supplementation with CLA may be a viable strategy to prevent pathological cardiac hypertrophy, a major risk factor for heart failure...
  93. doi Pioglitazone, a thiazolidinedione derivative, attenuates left ventricular hypertrophy and fibrosis in salt-sensitive hypertension
    Minori Nakamoto
    Department of Cardiovascular Medicine, Nephrology and Neurology, School of Medicine, University of the Ryukyus, Okinawa, Japan
    Hypertens Res 31:353-61. 2008
    ..Improvement in blood pressure, insulin level, and oxidative stress may be associated with this beneficial action of pioglitazone...
  94. doi Comparison between single and combined treatment with candesartan and pioglitazone following transient focal ischemia in rat brain
    Kristin Schmerbach
    Center for Cardiovascular Research Institute of Pharmacology, Charite Universitatsmedizin Berlin, Berlin, Germany
    Brain Res 1208:225-33. 2008
    ..Therefore, we conclude that a direct synergistic neuroprotective action of parallel ARB and TZD treatment is unlikely...
  95. pmc Mineralocorticoid receptor blockade reverses obesity-related changes in expression of adiponectin, peroxisome proliferator-activated receptor-gamma, and proinflammatory adipokines
    Christine Guo
    Division of Endocrinology, Diabetes, and Hypertension, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Circulation 117:2253-61. 2008
    ....
  96. doi Cardioprotective mechanism of telmisartan via PPAR-gamma-eNOS pathway in dahl salt-sensitive hypertensive rats
    Naohiko Kobayashi
    Department of Hypertension and Cardiorenal Medicine, Dokkyo Medical University School of Medicine, Mibu, Tochigi, Japan
    Am J Hypertens 21:576-81. 2008
    ....
  97. doi Peroxisome proliferator-activated receptor gamma agonist, rosiglitazone, suppresses CD40 expression and attenuates inflammatory responses after lithium pilocarpine-induced status epilepticus in rats
    Hong Sun
    Research Center of Epilepsy, Department of Neurology, Xijing Hospital, the Fourth Military Medicine University of Chinese PLA, Xi an, Shaanxi Province, China
    Int J Dev Neurosci 26:505-15. 2008
    ..Our data also support the idea that rosiglitazone might be a potential neuroprotective agent in epilepsy...
  98. doi Neuroprotective effect of the new thiadiazolidinone NP00111 against oxygen-glucose deprivation in rat hippocampal slices: implication of ERK1/2 and PPARgamma receptors
    Angelo O Rosa
    Departamento de Farmacologia y Terapeutica, Facultad de Medicina, Instituto Teofilo Hernando, Universidad Autonoma de Madrid, Spain
    Exp Neurol 212:93-9. 2008
    ..In conclusion, the novel TDZD NP00111 was protective against OGD in rat hippocampal slices by a mechanism related to phosphorylation of ERK1/2 via activation of PPARgamma...
  99. pmc Rosiglitazone, a PPAR gamma agonist, attenuates inflammation after surgical brain injury in rodents
    Amy Hyong
    Department of Physiology and Pharmacology, Loma Linda University School of Medicine, Loma Linda, CA, USA
    Brain Res 1215:218-24. 2008
    ..This study was designed to evaluate the neuroprotective effects of RSG in a rodent model of SBI...
  100. doi Additive inhibitory effect of experimentally induced hepatic cirrhosis by agonists of peroxisome proliferator activator receptor gamma and retinoic acid receptor
    Rafael Bruck
    Department of Gastroenterology and Liver Diseases, Tel Aviv Sourasky Medical Center, 6 Weizman, Tel Aviv, Israel
    Dig Dis Sci 54:292-9. 2009
    ..We have investigated the ability of the combination of PPAR gamma ligand rosiglitazone (RSG) and of ATRA to prevent liver fibrosis...

Research Grants3

  1. Poly (ADP-Ribose) synthetase in expression of endothelia
    Basilia Zingarelli; Fiscal Year: 2003
    ..abstract_text> ..
  2. PPAR gamma Signaling and Lung Fibroblast Transdifferentiation
    Virender Rehan; Fiscal Year: 2009
    ..abstract_text> ..
  3. Manganese and basal ganglia dysfunction: role of NO
    Ronald B Tjalkens; Fiscal Year: 2010
    ..abstract_text> ..