Pecam1

Summary

Gene Symbol: Pecam1
Description: platelet and endothelial cell adhesion molecule 1
Alias: CD31, Pecam, platelet endothelial cell adhesion molecule, PECAM-1, platelet/endothelial cell adhesion molecule 1
Species: rat

Top Publications

  1. pmc PECAM-1 engagement counteracts ICAM-1-induced signaling in brain vascular endothelial cells
    Jean Pierre Couty
    Institut Cochin, Universite Paris Descartes, CNRS UMR 8104, Paris, France
    J Neurochem 103:793-801. 2007
  2. ncbi Polymorphisms in the platelet-endothelial cell adhesion molecule-1 (PECAM-1) gene, Asn563Ser and Gly670Arg, associated with myocardial infarction in the Japanese
    T Sasaoka
    Department of Internal Medicine and Cardiology, Kitasato University School of Medicine, Kanagawa, Japan
    Ann N Y Acad Sci 947:259-69; discussion 269-70. 2001
  3. ncbi Antibody to platelet/endothelial cell adhesion molecule-1 reduces myocardial infarct size in a rat model of ischemia-reperfusion injury
    R J Gumina
    Medical College of Wisconsin, Department of Cellular Biology and Anatomy, Milwaukee 53226, USA
    Circulation 94:3327-33. 1996
  4. ncbi The protein-tyrosine phosphatase SHP-2 associates with tyrosine-phosphorylated adhesion molecule PECAM-1 (CD31)
    K Sagawa
    Receptors and Signal Transduction Section, OIIB, NIDR, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 272:31086-91. 1997
  5. ncbi Involvement of platelet-endothelial cell adhesion molecule-1 in neutrophil recruitment in vivo
    A A Vaporciyan
    Department of Pathology, University of Michigan Medical School, Ann Arbor 48109
    Science 262:1580-2. 1993
  6. pmc Monoclonal antibody to murine PECAM-1 (CD31) blocks acute inflammation in vivo
    S Bogen
    Department of Pathology, Boston University School of Medicine, Massachusetts 02118 2394
    J Exp Med 179:1059-64. 1994
  7. ncbi Platelet endothelial cell adhesion molecule-1 in neutrophil emigration during acute bacterial pneumonia in mice and rats
    Sadatomo Tasaka
    Department of Pediatrics, Rainbow Babies and Children s Hospital, Case Western Reserve University, Cleveland, Ohio 44106, USA
    Am J Respir Crit Care Med 167:164-70. 2003
  8. pmc Differences in platelet endothelial cell adhesion molecule-1 expression between peripheral circulation and pancreatic microcirculation in cerulein-induced acute edematous pancreatitis
    Hong Kai Gao
    Department of General Surgery, Division of Digestive Surgery and Organ Microcirculation, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China
    World J Gastroenterol 11:661-4. 2005
  9. doi Epidemiological, clinical, and laboratory characteristics of 48 cases of "Babesia venatorum" infection in China: a descriptive study
    Jia Fu Jiang
    State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, China
    Lancet Infect Dis 15:196-203. 2015
  10. ncbi Matrix metalloproteinase inhibitor (ONO-4817) attenuates ischemia-reperfusion injury in rat lung
    Takehiko Shimoyama
    Department of Cardio Thoracic Surgery, Graduate School of Medicine, Tokyo Medical and Dental University, Tokyo, Japan
    Med Sci Monit 12:BR51-6. 2006

Research Grants

  1. scVEGF Targeted Radiotherapy of Mammary and Colonic Cancer
    FRANCIS GERARD BLANKENBERG; Fiscal Year: 2010
  2. Caveolin-1 and NO Regulate PMN-mediated Increases in Vascular Permeability
    Richard D Minshall; Fiscal Year: 2011
  3. IMAGING APOPTOSIS IN VIVO WITH TECHNETIUM 99M ANNEXIN
    Francis Blankenberg; Fiscal Year: 2001
  4. Zeiss Dynamic Laser TIRF
    Richard Minshall; Fiscal Year: 2007
  5. IMAGING APOPTOSIS IN VIVO WITH TECHNETIUM 99M ANNEXIN
    Francis Blankenberg; Fiscal Year: 2007

Scientific Experts

  • H Kroll
  • Tarvinder S Dhanjal
  • Takehiko Shimoyama
  • Carmen E Pepene
  • Y Tada
  • Richard Minshall
  • Ugo Fiocco
  • Nicholas A Pullen
  • Tao Sheng Li
  • FRANCIS GERARD BLANKENBERG
  • K Wenzel
  • Mohamed A Elrayess
  • Walter L Murfee
  • Katrin Neubauer
  • H J Baelde
  • D Nassar
  • Michael S Pepper
  • Sahdeo Prasad
  • Vivek R Yadav
  • Hong Kai Gao
  • Jia Fu Jiang
  • Maurits de Vries
  • Pierre Emmanuel Rautou
  • Nathalie Gaudreault
  • Charity E Onore
  • Sunil Krishnan
  • Silke Cameron
  • Ana Cristina Breithaupt-Faloppa
  • Bharat B Aggarwal
  • V A Guazzone
  • Danna M Breen
  • Veronica Tisato
  • Ling Ling Yang
  • Chih Feng Chian
  • Laura Brudecki
  • E Somers
  • Juan M Jimenez-Andrade
  • Ryohei Miyazaki
  • Mineaki Kitamura
  • M Pirro
  • Bin Wang
  • Rabindranath Persad
  • Noboru Ikarashi
  • Sarah Katzenell
  • L E Mkonyi
  • Jamie R Privratsky
  • Sushovan Guha
  • M Oraei
  • Bokyung Sung
  • Guoquan Liu
  • Yilu Ye
  • Y Qu
  • Fang Fang
  • Xiao Xia Wang
  • Vishal Jhanji
  • Anil Sebastian
  • Tao Liu
  • Yu Mei Liu
  • Taku Rokutanda
  • Maureen Pickarski
  • Tomasz Jaworski
  • C B Hebeda
  • Joseph Shalhoub
  • C Livezeanu
  • Luke L Gompels
  • Xiao Dong Wang
  • Yoshihide Asano
  • Cristina B Hebeda
  • Heba Mourad
  • Emilie Groyer
  • Jean Pierre Couty
  • Beata Kiersnowska-Rogowska
  • Cun Wang
  • Fang Hai Han
  • F Listi
  • Zong guang Zhou
  • K Sagawa
  • You Qin Chen
  • Sherif Ibrahim
  • Sadatomo Tasaka
  • Nan Nan Yao
  • Yuan Chun Zheng
  • Yan Li Chu
  • Qiu Bo Huo
  • Bao Gui Jiang
  • Tie Sun
  • Na Jia
  • Xue Bing Ni
  • Rui Ruo Jiang
  • Hao Li

Detail Information

Publications83

  1. pmc PECAM-1 engagement counteracts ICAM-1-induced signaling in brain vascular endothelial cells
    Jean Pierre Couty
    Institut Cochin, Universite Paris Descartes, CNRS UMR 8104, Paris, France
    J Neurochem 103:793-801. 2007
    ..In the present study, we show that, whereas PECAM-1 is known to control positively the trans-endothelial migration of leukocytes via homophilic interactions between ..
  2. ncbi Polymorphisms in the platelet-endothelial cell adhesion molecule-1 (PECAM-1) gene, Asn563Ser and Gly670Arg, associated with myocardial infarction in the Japanese
    T Sasaoka
    Department of Internal Medicine and Cardiology, Kitasato University School of Medicine, Kanagawa, Japan
    Ann N Y Acad Sci 947:259-69; discussion 269-70. 2001
    We examined three missense polymorphisms of platelet-endothelial cell adhesion molecule-1 (PECAM-1), Val125Leu, Asn563Ser, and Gly670Arg, in 136 Japanese patients with myocardial infarction and 235 healthy Japanese controls...
  3. ncbi Antibody to platelet/endothelial cell adhesion molecule-1 reduces myocardial infarct size in a rat model of ischemia-reperfusion injury
    R J Gumina
    Medical College of Wisconsin, Department of Cellular Biology and Anatomy, Milwaukee 53226, USA
    Circulation 94:3327-33. 1996
    ..Platelet/endothelial cell adhesion molecule-1 (PECAM-1) is an immunoglobulin gene superfamily member expressed constitutively on neutrophils and endothelium...
  4. ncbi The protein-tyrosine phosphatase SHP-2 associates with tyrosine-phosphorylated adhesion molecule PECAM-1 (CD31)
    K Sagawa
    Receptors and Signal Transduction Section, OIIB, NIDR, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 272:31086-91. 1997
    ..We previously observed the tyrosine phosphorylation of the platelet/endothelial cell adhesion molecule, PECAM-1 (CD31), after FcepsilonRI stimulation in rat basophilic leukemia RBL-2H3 cells...
  5. ncbi Involvement of platelet-endothelial cell adhesion molecule-1 in neutrophil recruitment in vivo
    A A Vaporciyan
    Department of Pathology, University of Michigan Medical School, Ann Arbor 48109
    Science 262:1580-2. 1993
    ..In vitro assays have suggested that platelet-endothelial cell adhesion molecule-1 [PECAM-1 (CD31)], a member of the immunoglobulin superfamily, is required for the transmigration of neutrophils across ..
  6. pmc Monoclonal antibody to murine PECAM-1 (CD31) blocks acute inflammation in vivo
    S Bogen
    Department of Pathology, Boston University School of Medicine, Massachusetts 02118 2394
    J Exp Med 179:1059-64. 1994
    A murine model of peritonitis was used to test the role of platelet/endothelial cell adhesion molecule 1 (PECAM-1/CD31) in acute inflammation...
  7. ncbi Platelet endothelial cell adhesion molecule-1 in neutrophil emigration during acute bacterial pneumonia in mice and rats
    Sadatomo Tasaka
    Department of Pediatrics, Rainbow Babies and Children s Hospital, Case Western Reserve University, Cleveland, Ohio 44106, USA
    Am J Respir Crit Care Med 167:164-70. 2003
    b>Platelet endothelial cell adhesion molecule-1 (PECAM-1) (CD31) is an adhesion molecule believed to mediate transendothelial migration of neutrophils and other leukocytes after CD11/CD18-mediated adhesion...
  8. pmc Differences in platelet endothelial cell adhesion molecule-1 expression between peripheral circulation and pancreatic microcirculation in cerulein-induced acute edematous pancreatitis
    Hong Kai Gao
    Department of General Surgery, Division of Digestive Surgery and Organ Microcirculation, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China
    World J Gastroenterol 11:661-4. 2005
    To investigate the changes of platelet endothelial cell adhesion molecule-1 (PECAM-1) expression on polymorphonuclear leukocytes (PMNs) in peripheral circulation and pancreatic microcirculation in cerulein-induced acute edematous ..
  9. doi Epidemiological, clinical, and laboratory characteristics of 48 cases of "Babesia venatorum" infection in China: a descriptive study
    Jia Fu Jiang
    State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, China
    Lancet Infect Dis 15:196-203. 2015
    ..We aimed to describe the epidemiological, clinical, and laboratory characteristics of a series of cases with "B venatorum" infection identified in a sentinel hospital in China...
  10. ncbi Matrix metalloproteinase inhibitor (ONO-4817) attenuates ischemia-reperfusion injury in rat lung
    Takehiko Shimoyama
    Department of Cardio Thoracic Surgery, Graduate School of Medicine, Tokyo Medical and Dental University, Tokyo, Japan
    Med Sci Monit 12:BR51-6. 2006
    ..Therefore, we used a novel MMP inhibitor (ONO-4817) with high affinities for MMP-2 and MMP-9 to investigate the roles of MMPs in reperfusion injury of the lungs...
  11. ncbi A novel role for PECAM-1 in megakaryocytokinesis and recovery of platelet counts in thrombocytopenic mice
    Tarvinder S Dhanjal
    Centre for Cardiovascular Sciences, Institute of Biomedical Research, Division of Medical Sciences, The Medical School, University of Birmingham, Birmingham, United Kingdom
    Blood 109:4237-44. 2007
    ..In this study, we report a role for the glycoprotein PECAM-1 in thrombopoiesis...
  12. pmc Decrease of PECAM-1-gene-expression induced by proinflammatory cytokines IFN-gamma and IFN-alpha is reversed by TGF-beta in sinusoidal endothelial cells and hepatic mononuclear phagocytes
    Katrin Neubauer
    University of Gottingen, Department of Internal Medicine, Section of Gastroenterology and Endocrinology, Gottingen, Germany
    BMC Physiol 8:9. 2008
    ..This study aims to identify in vitro conditions (cytokine treatment) which may allow a better understanding of the changes in PECAM (platelet endothelial cell adhesion molecule)-1-gene-expression observed in vivo.
  13. doi Progenitor cell mobilization enhances bone healing by means of improved neovascularization and osteogenesis
    Xiao Xia Wang
    Institute of Reconstructive Plastic Surgery, New York University Langone Medical Center, New York, NY 10016, USA
    Plast Reconstr Surg 128:395-405. 2011
    ..Because adequate blood supply is essential to osteogenesis, the authors hypothesize that augmenting neovascularization by increasing the number of circulating progenitor cells will improve bony healing...
  14. pmc Dendritic degeneration, neurovascular defects, and inflammation precede neuronal loss in a mouse model for tau-mediated neurodegeneration
    Tomasz Jaworski
    Laboratory of Experimental Genetics and Transgenesis Experimental Genetics Group LEGTEGG, Department of Human Genetics, Katholieke Universiteit Leuven, Leuven, Belgium
    Am J Pathol 179:2001-15. 2011
    ....
  15. doi Matrix metalloproteinase-1 expression enhances tumorigenicity as well as tumor-related angiogenesis and is inversely associated with TIMP-4 expression in a model of glioblastoma
    Nicholas A Pullen
    Department of Anatomy and Neurobiology, Virginia Commonwealth University, Richmond, VA, USA
    J Neurooncol 106:461-71. 2012
    ..b>CD31 analysis of model tumors elucidated a substantial recruitment of endothelium in MMP-1 enhanced samples...
  16. doi Acceleration of cutaneous healing by electrical stimulation: degenerate electrical waveform down-regulates inflammation, up-regulates angiogenesis and advances remodeling in temporal punch biopsies in a human volunteer study
    Anil Sebastian
    Plastic and Reconstructive Surgery Research, School of Translational Medicine, Manchester Interdisciplinary Biocentre, The University of Manchester, Manchester, United Kingdom
    Wound Repair Regen 19:693-708. 2011
    ..05) of CD31 (15.5%), vascular endothelial growth factor (66%), and Melan A (8.6 cells/0.95 mm²) in ESD14 compared to NSD14 (9...
  17. doi Soluble platelet/endothelial cell adhesion molecule (sPECAM)-1 is increased in polycystic ovary syndrome and related to endothelial dysfunction
    Carmen Emanuela Pepene
    Department of Endocrinology, University of Medicine and Pharmacy Cluj Napoca, Romania
    Gynecol Endocrinol 28:370-4. 2012
    ..Platelet/endothelial cell adhesion molecule (PECAM)-1 is a soluble (s) signaling molecule involved in inflammation and angiogenesis with predictive value for ..
  18. pmc Comparison of the therapeutic effects of extracts from Spirulina platensis and amnion membrane on inflammation-associated corneal neovascularization
    Ling Ling Yang
    State Key Laboratory Cultivation Base, Shandong Provincial Key Lab of Ophthalmology, Shandong Eye Institute, Qingdao, China
    Int J Ophthalmol 5:32-7. 2012
    ..To compare the therapeutic effects of polysaccharide extract from Spirulina platensis (PSP) and extract from amnion membrane (AME) on alkali burn-induced corneal neovascularization (CorNV)...
  19. doi Effects of atorvastatin in the regulation of circulating EPCs and angiogenesis in traumatic brain injury in rats
    Bin Wang
    Department of Neurosurgery, Tianjin Medical University General Hospital, Tianjin, PR China
    J Neurol Sci 319:117-23. 2012
    ..Blood circulating EPCs were identified by flow cytometry. Rats were sacrificed 25 days after TBI. vWF and CD31 immunostaining was performed...
  20. pmc Levels of soluble platelet endothelial cell adhesion molecule-1 and P-selectin are decreased in children with autism spectrum disorder
    Charity E Onore
    Department of Medical Microbiology and Immunology, University of California, Davis, CA, USA
    Biol Psychiatry 72:1020-5. 2012
    ..Findings of immune dysfunction in ASD include increases in inflammatory cytokines, chemokines, and microglial activity in brain tissue and cerebrospinal fluid, as well as abnormal peripheral immune cell function...
  21. ncbi Association between platelet endothelial cellular adhesion molecule 1 (PECAM-1/CD31) polymorphisms and acute myocardial infarction: a study in patients from Sicily
    F Listi
    Gruppo di Studio sull Immunosenescenza, Dipartiento di Biopatologia e Metodologie Biomediche, Universita di Palermo, Italy
    Eur J Immunogenet 31:175-8. 2004
    ..Platelet endothelial cellular adhesion molecule 1 (PECAM-1/CD31), involved in this migration, has been associated with the developmental course of atherosclerosis...
  22. ncbi Aggregation of the high affinity IgE receptor results in the tyrosine phosphorylation of the surface adhesion protein PECAM-1 (CD31)
    K Sagawa
    Laboratory of Immunology, NIDR, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 272:13412-8. 1997
    ..the rat basophilic leukemia RBL-2H3 cells, we identified that platelet/endothelial cell adhesion molecule 1 (PECAM-1 or CD31) was tyrosine phosphorylated in these cells...
  23. pmc Hyperglycemia-induced vasculopathy in the murine vitelline vasculature: correlation with PECAM-1/CD31 tyrosine phosphorylation state
    E Pinter
    Departments of Pathology and Pediatrics, Yale University, Alexion Pharmaceuticals, Inc, New Haven, Connecticut, USA
    Am J Pathol 154:1367-79. 1999
    ..b>PECAM-1 expression has been observed during the earliest stages of vasculogenesis, and changes in PECAM-1 tyrosine ..
  24. ncbi Divergent effects of platelet-endothelial cell adhesion molecule-1 and beta 3 integrin blockade on leukocyte transmigration in vivo
    R D Thompson
    BHF Cardiovascular Medicine Unit, Imperial College School of Medicine at the National Heart and Lung Institute, Hammersmith Hospital, UK
    J Immunol 165:426-34. 2000
    ..Both platelet-endothelial cell adhesion molecule-1 (PECAM-1/CD31) and the integrin alphavbeta3 have been implicated in this process, and in vitro studies have identified ..
  25. ncbi Platelet endothelial cell adhesion molecule-1 (PECAM-1) is a target glycoprotein in drug-induced thrombocytopenia
    H Kroll
    Institute for Clinical Immunology and Transfusion Medicine, Justus Liebig University Giessen, Germany
    Blood 96:1409-14. 2000
    ..experiments with biotin-labeled platelets and endothelial cells, reactivity with the platelet endothelial cell adhesion molecule-1 (PECAM-1, CD31) could be demonstrated, whereas neither GPIIb/IIIa nor GPIb/IX was ..
  26. ncbi Effective treatment of gut barrier dysfunction using an antioxidant, a PAF inhibitor, and monoclonal antibodies against the adhesion molecule PECAM-1
    Zhengwu Sun
    Department of Surgery, Lund University Hospital, Lund University, S 221 85 Lund, Sweden
    J Surg Res 105:220-33. 2002
    ..the OFRs-scavenger (NAC), the PAF inhibitor lexipafant, and monoclonal antibodies against the adhesion molecule PECAM-1 (anti-PECAM-1-Mab) have been reported to be effective in the prevention or recovery of gut barrier dysfunction ..
  27. ncbi Clinical relevance of the expression of the CD31 ligand for CD38 in patients with B-cell chronic lymphocytic leukemia
    Sherif Ibrahim
    Section of Molecular Hematopathology, New York University, New York, New York, USA
    Cancer 97:1914-9. 2003
    CD31 (platelet endothelial cell adhesion molecule-1 [PECAM-1]) is the ligand for CD38, a transmembrane glycoprotein that is expressed on the surface of leukemic cells in many patients with B-cell chronic lymphocytic leukemia (B-CLL)...
  28. ncbi R643G polymorphism in PECAM-1 influences transendothelial migration of monocytes and is associated with progression of CHD and CHD events
    Mohamed A Elrayess
    Centre for Cardiovascular Genetics, British Heart Foundation Laboratories, Rayne Building, 5 University Street, UCL, London WC1E 6JF, UK
    Atherosclerosis 177:127-35. 2004
    The 643R allele of R643G polymorphism (also known as R670G in the premature protein) in PECAM-1 has been associated with risk of myocardial infarction (MI), while the 643G allele has been associated with risk of coronary artery stenosis (..
  29. ncbi Acceleration of the onset of collagen-induced arthritis by a deficiency of platelet endothelial cell adhesion molecule 1
    Yoshifumi Tada
    Saga Medical School, Saga, Japan
    Arthritis Rheum 48:3280-90. 2003
    b>Platelet endothelial cell adhesion molecule 1 (PECAM-1; CD31) is a member of the immunoglobulin superfamily that is expressed in platelets, leukocytes, and endothelial cells...
  30. doi Imbalance between endothelial injury and repair in patients with polymyalgia rheumatica: improvement with corticosteroid treatment
    M Pirro
    Unit of Internal Medicine, Angiology and Arteriosclerosis, Department of Clinical and Experimental Medicine, University of Perugia, Perugia, Italy
    J Intern Med 272:177-84. 2012
    ..We investigated the association between inflammation and endothelial injury and repair in patients with PMR and evaluated the effects of corticosteroid therapy on EMP and EPC levels...
  31. ncbi [Estimation of level of soluble form PECAM-1, ICAM-2 and TNF-alpha, IL-18 in serum patients with chronic myelogenic leukemia]
    Beata Kiersnowska-Rogowska
    Klinika Hematologil Akademii Medycznej w Białymstoku
    Przegl Lek 62:772-4. 2005
    ..High concentration of TNF-alpha and 11-18 in blood serum may indicate high expression of sPECAM-1 by activated specific enzymes responsible for releasing sPECAM-1...
  32. doi Erythropoietin, but not asialoerythropoietin or carbamyl-erythropoietin, attenuates monocrotaline-induced pulmonary hypertension in rats
    Noboru Ikarashi
    Division of Cardiology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Clin Exp Hypertens 34:575-81. 2012
    ..administration increased mRNA expression of the anti-apoptotic molecule, Bcl-xL, and maintained expression of the CD31 antigen. We conclude that lungs may express EPOR homoreceptors, but not heteroreceptors...
  33. pmc Endothelial Fli1 deficiency impairs vascular homeostasis: a role in scleroderma vasculopathy
    Yoshihide Asano
    Arthritis Center, Boston University Medical Center, Boston, MA 02118, USA
    Am J Pathol 176:1983-98. 2010
    ..expression of genes involved in maintaining vascular homeostasis including VE-cadherin, platelet endothelial cell adhesion molecule 1, type IV collagen, matrix metalloproteinase 9, platelet-derived growth factor B, and S1P(1) ..
  34. ncbi Heamostatic and genetic predisposing factors for stroke in children with sickle cell anemia
    Heba Mourad
    Department of Clinical Pathology, Faculty of Medicine, Tanta University, Egypt
    Egypt J Immunol 15:25-37. 2008
    ..FPA), thrombin-antithrombin III (TAT), fibrin degradation product (D-dimer) and serum level of platelet endothelial cell adhesion molecule-1 (PECAM-1), and analysis of the ACE gene polymorphism by polymerase chain reaction (PCR)...
  35. doi Isoliquiritigenin from licorice root suppressed neovascularisation in experimental ocular angiogenesis models
    Vishal Jhanji
    Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong
    Br J Ophthalmol 95:1309-15. 2011
    ..To explore the antiangiogenic property of isoliquiritigenin (ISL) on in vivo and in vitro models...
  36. doi Synovial biomarkers in psoriatic arthritis
    Ugo Fiocco
    Department of Medicine, University of Padua, Padua, Italy
    J Rheumatol Suppl 89:61-4. 2012
    ..5 mg)...
  37. pmc Endothelial cells obtained from patients affected by chronic venous disease exhibit a pro-inflammatory phenotype
    Veronica Tisato
    Department of Morphology and Embryology and LTTA Centre, University of Ferrara, Ferrara, Italy
    PLoS ONE 7:e39543. 2012
    ..Therefore, new insights on the characteristics of large vein endothelium would increase our knowledge of large vessel physiopathology...
  38. doi Resveratrol inhibits neointimal formation after arterial injury through an endothelial nitric oxide synthase-dependent mechanism
    Danna M Breen
    Department of Physiology, University of Toronto, Toronto, Ontario, M5S 1A8 Canada
    Atherosclerosis 222:375-81. 2012
    ..01), decreased intimal cell proliferation by 37% (P<0.01) and reduced inflammatory markers such as PECAM and MMP-9 mRNA. These effects of RSV were all abolished by coadministration of l-NAME...
  39. ncbi Huanglian-Jie-Du-Tang extract protects against chronic brain injury after focal cerebral ischemia via hypoxia-inducible-factor-1α-regulated vascular endothelial growth factor signaling in mice
    Yilu Ye
    Department of Pharmacology, Zhejiang Medical College, Hangzhou, China
    Biol Pharm Bull 35:355-61. 2012
    ..There were few cells positive for CD31, hypoxia-inducible-factor-1α (HIF-1α), vascular endothelial growth factor (VEGF) and Flk-1 in the sham control...
  40. pmc Acetylcholinesterase inhibitors attenuate angiogenesis
    Ryohei Miyazaki
    Department of Cardiovascular Medicine, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan
    Clin Sci (Lond) 123:241-9. 2012
    ..flow recovery examined by laser Doppler perfusion imaging and capillary density by immunohistochemical staining of CD31-positive cells in the ischaemic hindlimb were significantly decreased in donepezil- and physostigmine-treated mice ..
  41. ncbi [PECAM-1 and E-selectin expression in vulnerable plague and their relationships to myocardial Leu125Val polymorphism of PECAM-1 and Ser128Arg polymorphism of E-selectin in patients with acute coronary syndrome]
    Fang Fang
    Department of Pathology, Beijing Hospital, Beijing 100730, China
    Zhonghua Xin Xue Guan Bing Za Zhi 39:1110-6. 2011
    To observe the expression of PECAM-1 and E-selectin in the vulnerable plagues and their relationships to myocardial Leu125Val polymorphism of PECAM-1 and Ser128Arg polymorphism of E-selectin in autopsied samples of patients with acute ..
  42. ncbi [Role of endothelial progenitor cells in optic nerve injury of rats]
    Yu Mei Liu
    Department of Ophthalmology, Tianjin Medical University General Hospital, Tianjin 300052, China
    Zhonghua Yan Ke Za Zhi 47:1089-95. 2011
    ..To investigate the role of endothelial progenitor cells (EPC) in the injury of rat optic nerve...
  43. doi Radiation-induced damage in different segments of the rat intestine after external beam irradiation of the liver
    Silke Cameron
    Department of Gastroenterology and Endocrinology, University Clinic of the Georg August University, Robert Koch Str 40, D 37099 Göttingen, Germany
    Exp Mol Pathol 92:243-58. 2012
    ..The out-of-field effects on the intestine, caused by radiation treatment of a parenchymatous organ, have not previously been studied...
  44. pmc PECAM-1 dampens cytokine levels during LPS-induced endotoxemia by regulating leukocyte trafficking
    Jamie R Privratsky
    Blood Research Institute, BloodCenter of Wisconsin, Milwaukee, WI 53201, United States
    Life Sci 90:177-84. 2012
    To investigate the mechanism by which platelet endothelial cell adhesion molecule 1 (PECAM-1/CD31), an immunoglobulin (Ig)-superfamily cell adhesion and signaling receptor, regulates pro-inflammatory cytokine levels...
  45. doi Epigallocatechin gallate suppresses peritoneal fibrosis in mice
    Mineaki Kitamura
    Second Department of Internal Medicine, Nagasaki University School of Medicine, Japan
    Chem Biol Interact 195:95-104. 2012
    ..In the submesothelial compact zone of the MGO+saline-treated mice, CD31-positive vessels and vascular endothelial growth factor-positive cells were significantly increased, as were ..
  46. doi Lymphangiogenesis is induced during development of periodontal disease
    L E Mkonyi
    Department of Biomedicine, University of Bergen, Jonas Lies vei 91, Bergen, Norway
    J Dent Res 91:71-7. 2012
    ..Growth of lymphatic and blood vessels was measured after immunofluorescent staining with LYVE-1 and CD31. Expression of vascular endothelial growth factors and 2 inflammatory cytokines was investigated 10 days post-..
  47. pmc Molecular changes in articular cartilage and subchondral bone in the rat anterior cruciate ligament transection and meniscectomized models of osteoarthritis
    Maureen Pickarski
    Merck Sharpe and Dohme Corp, Bone Biology Group, West Point, PA 19486, USA
    BMC Musculoskelet Disord 12:197. 2011
    ..Osteoarthritis (OA) is a debilitating, progressive joint disease...
  48. doi Late-phase contrast-enhanced ultrasound reflects biological features of instability in human carotid atherosclerosis
    Joseph Shalhoub
    Academic Section of Vascular Surgery, Department of Experimental Medicine, Imperial College London, and Charing Cross Hospital, London W6 8RF, UK
    Stroke 42:3634-6. 2011
    ..We hypothesized that microbubbles are retained in areas of plaque inflammation, aiming to examine whether LP-CEUS signal reflects plaque biology...
  49. doi Targeted systemic radiotherapy with scVEGF/177Lu leads to sustained disruption of the tumor vasculature and intratumoral apoptosis
    Francis G Blankenberg
    Department of Radiology MIPS, Stanford University, Palo Alto, California, USA
    J Nucl Med 52:1630-7. 2011
    ....
  50. doi Passive exercise using whole-body periodic acceleration enhances blood supply to ischemic hindlimb
    Taku Rokutanda
    Department of Cardiovascular Medicine, Faculty of Life Sciences, Kumamoto University, 1 1 1 Honjo, Kumamoto, Kumamoto 860 8556, Japan
    Arterioscler Thromb Vasc Biol 31:2872-80. 2011
    ..We investigated the effects of WBPA on blood flow recovery in a mouse model of hindlimb ischemia and in patients with peripheral arterial disease...
  51. doi Abnormal plasma microparticles impair vasoconstrictor responses in patients with cirrhosis
    Pierre Emmanuel Rautou
    INSERM Unité 970, Paris Cardiovascular Research Center PARCC, Paris, France
    Gastroenterology 143:166-76.e6. 2012
    ..We investigated the cellular origins of MPs in plasma from patients with cirrhosis and assessed the contribution of MPs to arterial vasodilation, a mechanism that contributes to portal hypertension...
  52. pmc Human epidermal growth factor receptor bispecific ligand trap RB200: abrogation of collagen-induced arthritis in combination with tumour necrosis factor blockade
    Luke L Gompels
    Faculty of Medicine, Kennedy Institute of Rheumatology, 65 Aspenlea Road, London, W6 8LH, Imperial College London, London, UK
    Arthritis Res Ther 13:R161. 2011
    ..The objective of this study was to assess the effect of RB200 combined with TNF blockade in a murine collagen-induced arthritis (CIA) model of RA...
  53. doi Characterization of negatively charged phospholipids and cell origin of microparticles in women with gestational vascular complications
    Sarah Katzenell
    Bruce Rappaport Faculty of Medicine, Technion, Haifa, Israel
    Thromb Res 130:479-84. 2012
    ..Microparticles (MPs) are involved in thrombosis and inflammation. However, characterization and role of MPs in GVC have not been elucidated...
  54. pmc Sensory and sympathetic nerve fibers undergo sprouting and neuroma formation in the painful arthritic joint of geriatric mice
    Juan M Jimenez-Andrade
    Department of Pharmacology, University of Arizona, 1501 N, Campbell Avenue, Tucson, AZ 85724, USA
    Arthritis Res Ther 14:R101. 2012
    ..Here we explore whether sensory and sympathetic nerve fibers can undergo a significant ectopic nerve remodeling in the painful arthritic knee joint of geriatric mice...
  55. pmc Intratumoral hemorrhage, vessel density, and the inflammatory reaction contribute to volume increase of sporadic vestibular schwannomas
    Maurits de Vries
    Department of Otolaryngology, Leiden University Medical Center, P O Box 9600, 2300 RC, Leiden, The Netherlands
    Virchows Arch 460:629-36. 2012
    ..Immunohistochemical studies evaluated cell proliferation (histone H3 and Ki-67), microvessel density (CD31), and inflammation (CD45 and CD68). Intratumoral hemorrhage was assessed by hemosiderin deposition...
  56. doi Apocynin attenuates lipopolysaccharide-induced lung injury in an isolated and perfused rat lung model
    Chih Feng Chian
    Division of Pulmonary and Critical Care Medicine, Internal Medicine Department, Tri Service General Hospital, National Defense Medical Center, Taipei, Taiwan
    Shock 38:196-202. 2012
    ..Adhesion molecule of neutrophil (CD31) was upregulated...
  57. ncbi Naive CD4+ T cells and recent thymic emigrants in common variable immunodeficiency
    M Oraei
    Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
    J Investig Allergol Clin Immunol 22:160-7. 2012
    ..The aim of this study was to analyze levels of naïve CD4+ T cells and recent thymic emigrant (RTE) cells in CVID patients and healthy controls...
  58. pmc ICAM-1-activated Src and eNOS signaling increase endothelial cell surface PECAM-1 adhesivity and neutrophil transmigration
    Guoquan Liu
    Department of Pharmacology, University of Illinois, Chicago 60612, USA
    Blood 120:1942-52. 2012
    ..adhesion molecule-1 (ICAM-1)-dependent firm adhesion, and platelet/endothelial cell adhesion molecule 1 (PECAM-1)-mediated transendothelial migration...
  59. pmc Ursolic acid inhibits growth and metastasis of human colorectal cancer in an orthotopic nude mouse model by targeting multiple cell signaling pathways: chemosensitization with capecitabine
    Sahdeo Prasad
    Cytokine Research Laboratory, Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Clin Cancer Res 18:4942-53. 2012
    ..Whether ursolic acid, a component of numerous medicinal plants, either alone or in combination with capecitabine, can inhibit the growth and metastasis of human CRC was investigated...
  60. pmc Therapeutic effectiveness of intratumorally delivered dendritic cells engineered to express the pro-inflammatory cytokine, interleukin (IL)-32
    Y Qu
    Department of Dermatology, University of Pittsburgh School of Medicine, PA, USA
    Cancer Gene Ther 18:663-73. 2011
    ..infiltration of tumors by type-1 (that is, CXCR3(+)VLA-4(+)GrB(+)) CD8(+) T cells and CD11b(+)CD11c(+) host myeloid DC, but led to reductions in the prevalence of CD11b(+)Gr1(+) myeloid-derived suppressor cells and CD31(+) blood vessels.
  61. pmc Boswellic acid inhibits growth and metastasis of human colorectal cancer in orthotopic mouse model by downregulating inflammatory, proliferative, invasive and angiogenic biomarkers
    Vivek R Yadav
    Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Int J Cancer 130:2176-84. 2012
    ..we found that markers of tumor proliferation index Ki-67 and the microvessel density cluster of differentiation (CD31) were significantly downregulated by AKBA treatment...
  62. pmc Myeloid-derived suppressor cells evolve during sepsis and can enhance or attenuate the systemic inflammatory response
    Laura Brudecki
    Department of Internal Medicine, East Tennessee State University College of Medicine, Johnson City, Tennessee, USA
    Infect Immun 80:2026-34. 2012
    ..Late MDSCs had more immature CD31(+) myeloid progenitors and, when treated ex vivo with granulocyte-macrophage colony-stimulating factor (GM-CSF), ..
  63. doi Intestinal lymph-borne factors induce lung release of inflammatory mediators and expression of adhesion molecules after an intestinal ischemic insult
    Ana Cristina Breithaupt-Faloppa
    Department of Pharmacology, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, Brazil
    J Surg Res 176:195-201. 2012
    ....
  64. doi Expression of cell adhesion molecules, chemokines and chemokine receptors involved in leukocyte traffic in rats undergoing autoimmune orchitis
    V A Guazzone
    Instituto de Investigaciones en Reproducción, Universidad de Buenos Aires, Paraguay 2155 piso 10, C1121 ABG Ciudad Autónoma de Buenos Aires, Argentina
    Reproduction 143:651-62. 2012
    ..Thus, we investigated the expression of CCL3, its receptors, and adhesion molecules CD31 and CD106 in an in vivo model of experimental autoimmune orchitis (EAO)...
  65. pmc Diabetic impairment of C-kit bone marrow stem cells involves the disorders of inflammatory factors, cell adhesion and extracellular matrix molecules
    Tao Sheng Li
    Department of Stem Cell Biology, Nagasaki University Graduate School of Biomedical Science, Nagasaki, Japan
    PLoS ONE 6:e25543. 2011
    ..Interestingly, diabetes-related alterations of the extracellular matrix and adhesion molecules were varied; Pecam, Mmp10, Lamc1, Itgb7, Mmp9, and Timp4 were up-regulated, but Col11a1, Fn1, Admts2, and Itgav were down-regulated...
  66. ncbi Angiogenesis in the pathogenesis of pterygium
    C Livezeanu
    Department of Histology, University of Medicine and Pharmacy of Craiova, Romania
    Rom J Morphol Embryol 52:837-44. 2011
    ..Angiogenesis in the pterygion was investigated with CD31 marker that allows the identification of the vascular endothelium and the establishment of the vascular ..
  67. pmc ApoE suppresses atherosclerosis by reducing lipid accumulation in circulating monocytes and the expression of inflammatory molecules on monocytes and vascular endothelium
    Nathalie Gaudreault
    Department of Surgery, University of California San Francisco and VA Medical Center, 4150 Clement Street, San Francisco, CA 94121, USA
    Arterioscler Thromb Vasc Biol 32:264-72. 2012
    ..We hypothesized that apoE reduces atherosclerosis by decreasing lipid accumulation in circulating monocytes and the inflammatory state of monocytes and the vascular endothelium...
  68. doi Angiogenic remodeling in pediatric EoE is associated with increased levels of VEGF-A, angiogenin, IL-8, and activation of the TNF-α-NFκB pathway
    Rabindranath Persad
    Department of Paediatrics, University of Alberta, Edmonton, Canada
    J Pediatr Gastroenterol Nutr 55:251-60. 2012
    ..The aims of this study were to determine the angiogenic profile of esophageal mucosa in children presenting with EoE and to evaluate the putative mechanism(s) underlying the early inflammatory angiogenic response observed in EoE...
  69. ncbi Atheroprotective effect of CD31 receptor globulin through enrichment of circulating regulatory T-cells
    Emilie Groyer
    INSERM UMR S 872, Paris, France
    J Am Coll Cardiol 50:344-50. 2007
    This study was designed to evaluate whether replacing CD31 (PECAM-1) signaling can restore the regulation of lymphocyte activation and improve experimental atherosclerosis.
  70. doi Density, calibre and ramification of muscle capillaries are altered in a mouse model of severe spinal muscular atrophy
    E Somers
    Euan MacDonald Centre for Motor Neurone Disease Research, University of Edinburgh, Edinburgh, UK
    Neuromuscul Disord 22:435-42. 2012
    ..controls at early and late symptomatic time points, and reduced expression of a key endothelial protein, PECAM-1...
  71. doi Effects of icariin on improving erectile function in streptozotocin-induced diabetic rats
    Tao Liu
    Andrology Center, Peking University First Hospital, Beijing, China
    J Sex Med 8:2761-72. 2011
    ..The effects of icariin on penile hemodynamics in diabetic animals remain to be determined. Transforming growth factor β1 (TGFβ1) has been implicated in the pathogenesis of diabetes-related erectile dysfunction...
  72. doi In vivo blockade of Ca(+2)-dependent nitric oxide synthases impairs expressions of L-selectin and PECAM-1
    Cristina B Hebeda
    Department of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences, University of Sao Paulo, Sao Paulo 0550 900, Av Prof Lineu Prestes 580 BI13 B, SP, Brazil
    Biochem Biophys Res Commun 377:694-8. 2008
    ..Expressions of L-selectin and PECAM-1 in peripheral leukocytes and PECAM-1 in endothelial cells were reduced by l-NAME treatment...
  73. ncbi Regulation of VEGF and VEGF receptor expression in the rodent mammary gland during pregnancy, lactation, and involution
    M S Pepper
    Department of Morphology, University Medical Center, Geneva, Switzerland
    Dev Dyn 218:507-24. 2000
    ..These results point to a causal role for the VEGF ligand-receptor pairs in pregnancy-associated angiogenesis in the mammary gland, and suggest that they may also regulate vascular permeability during lactation...
  74. ncbi A novel functional polymorphism in the PECAM-1 gene (53G>A) is associated with progression of atherosclerosis in the LOCAT and REGRESS studies
    Mohamed A Elrayess
    The Centre for Cardiovascular Genetics, British Heart Foundation Laboratories, Royal Free and University College Medical School, University College London, Rayne Building, 5 University Street, UK
    Atherosclerosis 168:131-8. 2003
    A 53G>A polymorphism identified in the 5' untranslated region (5'UTR) of the platelet endothelial cell adhesion molecule-1 (PECAM-1) gene alters a putative shear stress responsive element (SSRE)...
  75. ncbi Discontinuous expression of endothelial cell adhesion molecules along initial lymphatic vessels in mesentery: the primary valve structure
    Walter L Murfee
    Department of Bioengineering, University of California San Diego, 9500 Gilman Drive, Mail Code 0412, La Jolla, CA 92093, USA
    Lymphat Res Biol 5:81-9. 2007
    ..The objective of this study was to evaluate the expression pattern of adhesion molecules at endothelial cell junctions in an adult initial lymphatic network...
  76. ncbi The homozygous combination of Leu125Val and Ser563Asn polymorphisms in the PECAM1 (CD31) gene is associated with early severe coronary heart disease
    K Wenzel
    Medical Clinic I, Charite, Humboldt University, Berlin, Germany
    Hum Mutat 14:545. 1999
  77. ncbi Expression of platelet endothelial cell adhesion molecule-1 between pancreatic microcirculation and peripheral circulation in rats with acute edematous pancreatitis
    Hong Kai Gao
    Department of General Surgery and Institute of Digestive Surgery, West China Hospital, Sichuan University, Chengdu 610041, China
    Hepatobiliary Pancreat Dis Int 2:463-6. 2003
    To study the changes of platelet endothelial cell adhesion molecule-1 (PECAM-1) expression on polymorphonuclear leukocytes (PMNs) in peripheral circulation and pancreatic microcirculation in rats with acute edematous pancreatitis (AEP).
  78. doi Effect and mechanism of panaxoside Rg1 on neovascularization in myocardial infarction rats
    Xiao Dong Wang
    Department of Cardiac Surgery, The First Affiliated Hospital, China Medical University, Shenyang 110001, China
    Chin J Integr Med 16:162-6. 2010
    ..To investigate the effects and mechanisms of panaxoside Rg1 on the new vessel formation in acute myocardial infarction (AMI) rats...
  79. ncbi Gene expression profiling in glomeruli from human kidneys with diabetic nephropathy
    Hans J Baelde
    Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands
    Am J Kidney Dis 43:636-50. 2004
    ..To obtain more insight into processes that lead to DN, messenger RNA expression profiles of diabetic glomeruli and glomeruli from healthy individuals were compared...
  80. pmc Nitric oxide modulates lipopolysaccharide-induced endothelial platelet endothelial cell adhesion molecule expression via interleukin-10
    C B Hebeda
    Department of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences, University of Sao Paulo, Sao Paulo, Brazil
    Clin Exp Immunol 165:172-9. 2011
    We have shown previously that nitric oxide (NO) controls platelet endothelial cell adhesion molecule (PECAM-1) expression on both neutrophils and endothelial cells under physiological conditions...

Research Grants5

  1. scVEGF Targeted Radiotherapy of Mammary and Colonic Cancer
    FRANCIS GERARD BLANKENBERG; Fiscal Year: 2010
    ..Successful completion of our proposal will give the needed preclinical data for pursuing scVEGF targeted radiotherapy in other models and ultimately clinical applications. ..
  2. Caveolin-1 and NO Regulate PMN-mediated Increases in Vascular Permeability
    Richard D Minshall; Fiscal Year: 2011
    ....
  3. IMAGING APOPTOSIS IN VIVO WITH TECHNETIUM 99M ANNEXIN
    Francis Blankenberg; Fiscal Year: 2001
    ..abstract_text> ..
  4. Zeiss Dynamic Laser TIRF
    Richard Minshall; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  5. IMAGING APOPTOSIS IN VIVO WITH TECHNETIUM 99M ANNEXIN
    Francis Blankenberg; Fiscal Year: 2007
    ..Completion of this proposal will aid in the design and planning of clinical trials that will study the use of serial annexin V imaging as a non-invasive marker of cellular injury and therapeutic efficacy. ..