Pdgfrb

Summary

Gene Symbol: Pdgfrb
Description: platelet derived growth factor receptor beta
Alias: PDGFR-1, platelet-derived growth factor receptor beta, CD140 antigen-like family member B, PDGF-R-beta, PDGFR-beta, Platelet-derived growth factor receptor, beta, beta platelet-derived growth factor receptor, beta-type platelet-derived growth factor receptor, platelet derived growth factor receptor, beta polypeptide, platelet-derived growth factor receptor 1, platelet-derived growth factor receptor beta variant 1
Species: rat

Top Publications

  1. ncbi Dominant-negative soluble PDGF-beta receptor inhibits hepatic stellate cell activation and attenuates liver fibrosis
    Erawan Borkham-Kamphorst
    Institute of Clinical Chemistry and Pathobiochemistry, RWTH University Hospital, Aachen, Germany
    Lab Invest 84:766-77. 2004
  2. ncbi Effects of ribozyme targeting platelet-derived growth factor receptor beta subunit gene on the proliferation and apoptosis of hepatic stellate cells in vitro
    Yue Xiang Chen
    Department of Gastroenterology, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China
    Chin Med J (Engl) 118:982-8. 2005
  3. ncbi Functional blockade of platelet-derived growth factor receptor-beta but not of receptor-alpha prevents vascular smooth muscle cell accumulation in fibrous cap lesions in apolipoprotein E-deficient mice
    H Sano
    Departments of Geriatric Medicine, Graduate School of Medicine, Kyoto University, Japan
    Circulation 103:2955-60. 2001
  4. doi Activation of MAP kinases, Akt and PDGF receptors in injured peripheral nerves
    Takashi Yamazaki
    Department of Pathology, Graduate School of Medicine and Pharmaceutical Sciences for Research, University of Toyama, Toyama, Japan
    J Peripher Nerv Syst 14:165-76. 2009
  5. ncbi A high-potassium diet reduces infarct size and improves vascular structure in hypertensive rats
    Anne M Dorrance
    Department of Physiology, Medical College of Georgia, GA 30912 3000, USA
    Am J Physiol Regul Integr Comp Physiol 292:R415-22. 2007
  6. ncbi Response to imatinib mesylate in patients with chronic myeloproliferative diseases with rearrangements of the platelet-derived growth factor receptor beta
    Jane F Apperley
    Department of Haematology, Faculty of Medicine, Imperial College, Hammersmith Hospital, London, United Kingdom
    N Engl J Med 347:481-7. 2002
  7. ncbi Autoantigen-pulsed dendritic cells constitute a beneficial cytokine and growth factor network in ameliorating experimental allergic encephalomyelitis
    Xuan Liu
    Division of Neuroimmunology, Neurotec Department, Karolinska Institute, 14183 Huddinge, Stockholm, Sweden
    Mult Scler 11:381-9. 2005
  8. ncbi The effect of acute rejection and cyclosporin A-treatment on induction of platelet-derived growth factor and its receptors during the development of chronic rat renal allograft rejection
    Johanna Savikko
    Transplantation Laboratory, University of Helsinki and Helsinki University Central Hospital, P O Box 21 Haartmaninkatu 3, FIN 00014 University of Helsinki, Finland
    Transplantation 73:506-11. 2002
  9. ncbi Inhibition of platelet-derived growth factor actions in the embryonic testis influences normal cord development and morphology
    Mehmet Uzumcu
    Center for Reproductive Biology, School of Molecular Biosciences, Washington State University, Pullman, Washington 99164 4231, USA
    Biol Reprod 66:745-53. 2002
  10. doi Myocardin regulates vascular response to injury through miR-24/-29a and platelet-derived growth factor receptor-β
    Amarnath Talasila
    From the Division of Cardiovascular Medicine, University of Cambridge, Addenbrooke s Centre for Clinical Investigation, Addenbrooke s Hospital, Cambridge, United Kingdom A T, H Y, M A J, M R B, S S and Division of Biopharmaceutics, Leiden Amsterdam Centre for Drug Research, Leiden University, Einsteinweg, Leiden, The Netherlands M R B, T v B, I B
    Arterioscler Thromb Vasc Biol 33:2355-65. 2013

Research Grants

  1. Effects of intracellular angiotensin II
    Julia Cook; Fiscal Year: 2009
  2. PHOSPHORYLATION IN RENAL CELL INJURY
    Goutam Ghosh Choudhury; Fiscal Year: 2004
  3. Fi02 and Blood Vessel Formation in Adult Lung
    Rosemary Jones; Fiscal Year: 2006
  4. The Role of Tuberin in Smooth Muscle Cell Proliferation
    Geraldine Finlay; Fiscal Year: 2007

Scientific Experts

Detail Information

Publications82

  1. ncbi Dominant-negative soluble PDGF-beta receptor inhibits hepatic stellate cell activation and attenuates liver fibrosis
    Erawan Borkham-Kamphorst
    Institute of Clinical Chemistry and Pathobiochemistry, RWTH University Hospital, Aachen, Germany
    Lab Invest 84:766-77. 2004
    ....
  2. ncbi Effects of ribozyme targeting platelet-derived growth factor receptor beta subunit gene on the proliferation and apoptosis of hepatic stellate cells in vitro
    Yue Xiang Chen
    Department of Gastroenterology, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China
    Chin Med J (Engl) 118:982-8. 2005
    ..This study investigated the cleavage activity of hammerhead ribozyme targeting PDGFR-beta mRNA in HSC and the effect on biological characteristics of HSC...
  3. ncbi Functional blockade of platelet-derived growth factor receptor-beta but not of receptor-alpha prevents vascular smooth muscle cell accumulation in fibrous cap lesions in apolipoprotein E-deficient mice
    H Sano
    Departments of Geriatric Medicine, Graduate School of Medicine, Kyoto University, Japan
    Circulation 103:2955-60. 2001
    ..To clarify this problem, we prepared antagonistic rat monoclonal antibodies, APA5 and APB5, against murine PDGFR-alpha and PDGFR-beta, respectively...
  4. doi Activation of MAP kinases, Akt and PDGF receptors in injured peripheral nerves
    Takashi Yamazaki
    Department of Pathology, Graduate School of Medicine and Pharmaceutical Sciences for Research, University of Toyama, Toyama, Japan
    J Peripher Nerv Syst 14:165-76. 2009
    ..Furthermore, the immunohistological studies suggested a role of ERK and PDGFR-alpha in axon regeneration as well...
  5. ncbi A high-potassium diet reduces infarct size and improves vascular structure in hypertensive rats
    Anne M Dorrance
    Department of Physiology, Medical College of Georgia, GA 30912 3000, USA
    Am J Physiol Regul Integr Comp Physiol 292:R415-22. 2007
    ..These results suggest that potassium supplementation provides neuroprotection in a model of ischemic stroke independent of blood pressure and possibly through changes in vascular structure...
  6. ncbi Response to imatinib mesylate in patients with chronic myeloproliferative diseases with rearrangements of the platelet-derived growth factor receptor beta
    Jane F Apperley
    Department of Haematology, Faculty of Medicine, Imperial College, Hammersmith Hospital, London, United Kingdom
    N Engl J Med 347:481-7. 2002
    ..diseases have constitutive activation of the gene for platelet-derived growth factor receptor beta (PDGFRB), which encodes a receptor tyrosine kinase...
  7. ncbi Autoantigen-pulsed dendritic cells constitute a beneficial cytokine and growth factor network in ameliorating experimental allergic encephalomyelitis
    Xuan Liu
    Division of Neuroimmunology, Neurotec Department, Karolinska Institute, 14183 Huddinge, Stockholm, Sweden
    Mult Scler 11:381-9. 2005
    ..In line with the suppression of EAE induced by MBP-pulsed DC, the dynamic change of cytokines and growth factors in spinal cords should constitute a beneficial microenvironment against EAE...
  8. ncbi The effect of acute rejection and cyclosporin A-treatment on induction of platelet-derived growth factor and its receptors during the development of chronic rat renal allograft rejection
    Johanna Savikko
    Transplantation Laboratory, University of Helsinki and Helsinki University Central Hospital, P O Box 21 Haartmaninkatu 3, FIN 00014 University of Helsinki, Finland
    Transplantation 73:506-11. 2002
    ..We have investigated the impact of AR and different doses of CsA on the expression of PDGF ligands and receptors in the development of CR...
  9. ncbi Inhibition of platelet-derived growth factor actions in the embryonic testis influences normal cord development and morphology
    Mehmet Uzumcu
    Center for Reproductive Biology, School of Molecular Biosciences, Washington State University, Pullman, Washington 99164 4231, USA
    Biol Reprod 66:745-53. 2002
    ..b>PDGFR beta-receptor immunoreactivity was primarily localized to the mesonephros of E14 organs and the testicular ..
  10. doi Myocardin regulates vascular response to injury through miR-24/-29a and platelet-derived growth factor receptor-β
    Amarnath Talasila
    From the Division of Cardiovascular Medicine, University of Cambridge, Addenbrooke s Centre for Clinical Investigation, Addenbrooke s Hospital, Cambridge, United Kingdom A T, H Y, M A J, M R B, S S and Division of Biopharmaceutics, Leiden Amsterdam Centre for Drug Research, Leiden University, Einsteinweg, Leiden, The Netherlands M R B, T v B, I B
    Arterioscler Thromb Vasc Biol 33:2355-65. 2013
    ..Myocardin levels are reduced during vascular injury, in association with phenotypic switching of smooth muscle cells (SMCs). However, the direct role of myocardin in vascular disease is unclear...
  11. pmc Mechanical stretch increases MMP-2 production in vascular smooth muscle cells via activation of PDGFR-β/Akt signaling pathway
    Kyo Won Seo
    Department of Pharmacology, School of Medicine, and Medical Research Center for Ischemic Tissue Regeneration, Pusan National University, Yangsan, Gyeongnam, Republic of Korea
    PLoS ONE 8:e70437. 2013
    ..Collectively, our data indicate that MS induces MMP-2 production in VSMC via activation of Akt pathway, that is mediated by activation of PDGFR-β signaling pathways. ..
  12. ncbi Bolus endovascular PDGFR-beta antisense treatment suppressed intimal hyperplasia in a rat carotid injury model
    N Noiseux
    Montreal Heart Institute and Department of Pharmacology, University of Montreal, Montreal, Quebec, Canada
    Circulation 102:1330-6. 2000
    ....
  13. pmc Nilotinib-mediated mucosal healing in a rat model of colitis
    Pinar Ataca
    Pinar Ataca, Department of Internal Medicine, Dokuz Eylul University School of Medicine, Inciralti, Izmir 35340, Turkey
    World J Gastroenterol 19:6237-44. 2013
    ..To investigate the effects of nilotinib in a rat model of trinitrobenzene sulfonic acid (TNBS)-induced colitis...
  14. doi The tyrosine phosphatase SHP-1 inhibits proliferation of activated hepatic stellate cells by impairing PDGF receptor signaling
    Elena Tibaldi
    Department of Molecular Medicine, University of Padua, Viale G Colombo 3, 35131 Padua, Italy
    Biochim Biophys Acta 1843:288-98. 2014
    ....
  15. doi Peroxisome proliferator-activated receptor-γ interrupts angiogenic signal transduction by transrepression of platelet-derived growth factor-β receptor in hepatic stellate cells
    Feng Zhang
    Department of Pharmacology, College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China
    J Cell Sci 127:305-14. 2014
    ..PPARγ could be a molecular target for preventing vascular remolding in hepatic fibrosis. ..
  16. ncbi Better-surviving liver grafts by the injection of anti-CD2 antibody: the important roles of host CD8+ and CD2+CD28+ T cells in chronic graft rejection and beta type platelet-derived growth factor receptor (PDGFR-beta) expression on apoptotic liver grafts
    T Nakatsuji
    Department of Transfusion, Hamamatsu University School of Medicine, Japan
    Tohoku J Exp Med 187:215-25. 1999
    ..Prolonged graft survival was observed in only one of the 9 rats. Anti-CD2 MAb was effective for prolonging the liver graft survival with suppressed CD28 antigen, but anti-PDGFR-beta Ab and splenectomy were not...
  17. pmc Inflammatory cytokines promote growth of intestinal smooth muscle cells by induced expression of PDGF-Rβ
    Dileep G Nair
    Gastrointestinal Diseases Research Unit, Department of Medicine, Queen s University, Kingston, Ontario, Canada
    J Cell Mol Med 18:444-54. 2014
    ..Thus, pro-inflammatory cytokines both initiate and maintain a growth response in CSMC via PDGF-Rβ and serum-derived PDGF-BB, and control of PDGF-Rβ expression may be beneficial in chronic intestinal inflammation...
  18. doi IL-1β Induces MMP-9-Dependent Brain Astrocytic Migration via Transactivation of PDGF Receptor/NADPH Oxidase 2-Derived Reactive Oxygen Species Signals
    Chuen Mao Yang
    Department of Physiology and Pharmacology and Health Aging Research Center, College of Medicine, Chang Gung University, 259 Wen Hwa 1st Road, Kwei San, Tao Yuan, Taiwan
    Mol Neurobiol 52:303-17. 2015
    ..These results demonstrated that in RBA-1 cells, activation of NF-κB and AP-1 (ATF2) by the c-Src/PDGFR/PI3K/Akt-mediated Nox2/ROS/MAPKs signals is required for upregulation of MMP-9 and cell migration enhanced by IL-1β. ..
  19. ncbi Temporal changes in gene expression following cryogenic rat brain injury
    J L Cook
    Ochsner Medical Foundation, Division of Research, New Orleans, LA, USA
    Brain Res Mol Brain Res 55:9-19. 1998
    ..In the present model, many genes demonstrate elevated RNA levels in the cortex prior to hippocampus, following injury. RNAs transcribed from late genes tend to be elevated concurrently in cortex and hippocampus...
  20. doi Role of retinoic acid and platelet-derived growth factor receptor cross talk in the regulation of neonatal gonocyte and embryonal carcinoma cell differentiation
    Gurpreet Manku
    The Research Institute of the McGill University Health Centre G M, V M, A B, M C, Montreal, Quebec, Canada H3G1A4 Departments of Pharmacology and Therapeutics G M, M C Medicine M C, McGill University, Montreal, Quebec, Canada H3G1A4 Department of Biochemistry and Molecular and Cellular Biology Y W, Georgetown University Medical Center, Washington, DC 20057 and Protein Characterization Laboratory X Y, J B, Cancer Research Technology Program, Leidos Biomedical Research, Inc, Frederick National Laboratory for Cancer Research, National Cancer Institute, Frederick, Maryland 21702
    Endocrinology 156:346-59. 2015
    ..These results suggest that gonocyte and F9 cell differentiation is regulated via cross talk between RA and PDGFRs using different downstream pathways...
  21. doi Dihydroartemisinin alleviates bile duct ligation-induced liver fibrosis and hepatic stellate cell activation by interfering with the PDGF-βR/ERK signaling pathway
    Qin Chen
    Department of Pharmacology, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, Jiangsu Province, China
    Int Immunopharmacol 34:250-8. 2016
    ..These data collectively revealed that DHA relieved liver fibrosis possibly by targeting HSCs via the PDGF-βR/ERK pathway. DHA may be a therapeutic antifibrotic agent for the treatment of hepatic fibrosis. ..
  22. doi Clitocybin B inhibits rat aortic smooth muscle cell proliferation through suppressing PDGF-Rβ phosphorylation
    Kyu Dong Yoo
    College of Pharmacy, CBITRC, Chungbuk National University, Cheongju, Republic of Korea
    Vascul Pharmacol 56:91-7. 2012
    ..Thus, clitocybin B may be an effective antiproliferative agent for the prevention of atherosclerosis and restenosis...
  23. doi Activation of PDGFR and EGFR promotes the acquisition of a stem cell-like phenotype in schwannomas
    David Yi
    Division of Otolaryngology Head and Neck Surgery, Department of Surgery, University of California, San Diego, California, USA
    Otol Neurotol 33:1640-7. 2012
    ....
  24. ncbi Sphingosine 1-phosphate transactivates the platelet-derived growth factor beta receptor and epidermal growth factor receptor in vascular smooth muscle cells
    Tatsuo Tanimoto
    Center for Cardiovascular Research, University of Rochester, Rochester, NY 14642, USA
    Circ Res 94:1050-8. 2004
    ..These data establish S1P as an important stimulus for EGFR and PDGFbetaR activation in VSMCs that may have important implications for the vessel response to injury...
  25. ncbi PDGF receptor β signaling in pericytes following ischemic brain injury
    Koichi Arimura
    Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    Curr Neurovasc Res 9:1-9. 2012
    ..Thus, the PDGFRβ-Akt signaling in brain pericytes may play various important roles leading to neuroprotection after ischemic stroke...
  26. pmc Blockade of PDGFR-β activation eliminates morphine analgesic tolerance
    Yan Wang
    Department of Anesthesiology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA
    Nat Med 18:385-7. 2012
    ..PDGFR-β inhibitors are widely used and well tolerated, suggesting that clinical translation of our findings could reduce the suffering endured by individuals with intractable pain...
  27. ncbi Estrogen-induced smooth muscle cell growth is regulated by tuberin and associated with altered activation of platelet-derived growth factor receptor-beta and ERK-1/2
    Geraldine A Finlay
    Pulmonary and Critical Care Division, Department of Medicine, Tupper Research Institute, Tufts New England Medical Center, Boston, Massachusetts 02111, USA
    J Biol Chem 279:23114-22. 2004
    ..Furthermore, the opposing effects of tuberin on estrogen-induced activation of PDGFRbeta and ERK-1/-2 suggest a pivotal role for tuberin in directing the signaling events that dictate the growth response to E2...
  28. doi PDGF-β receptor and PKC have no effect on angiotensin II-induced JAK2 and STAT1 phosphorylation in vascular smooth muscle cells under high glucose condition
    Oktay Hasan Ozturk
    Department of Biochemistry, Medical School, Mustafa Kemal University, Antakya, Hatay, Turkey
    J Recept Signal Transduct Res 31:340-9. 2011
    ..In our study, we examined the role of PKC and PDGF receptor on JAK2 and STAT1 phosphorylation under high glucose (HG) condition (25 mmol/L) in response to Ang II in cultured vascular smooth muscle cells (VSMC)...
  29. doi PDGF- and insulin/IGF-1-specific distinct modes of class IA PI 3-kinase activation in normal rat retinas and RGC-5 retinal ganglion cells
    Swarajit K Biswas
    Penn State Heart and Vascular Institute, Penn State College of Medicine, Hershey, Pennsylvania 17033, USA
    Invest Ophthalmol Vis Sci 49:3687-98. 2008
    ..To compare PDGF- and insulin/IGF-1-induced class I(A) PI 3-kinase/Akt survival signaling in normal retinas and retinal ganglion cells (RGCs)...
  30. doi PDGFRβ triggered by bFGF promotes the proliferation and migration of endothelial progenitor cells via p-ERK signalling
    Sufen Guo
    Department of Pathology, Mudanjiang Medical University, People s Republic of China
    Cell Biol Int 36:945-50. 2012
    ..The findings strongly suggest that a PDGFRβ/p-ERK signalling pathway triggered by bFGF plays an important role in the proliferation and migration of EPCs...
  31. ncbi Expression of endothelial PDGF receptors alpha and beta in breast cancer: up-regulation of endothelial PDGF receptor beta
    T Vrekoussis
    Department of Obstetrics and Gynecology, University Hospital and Medical School, University of Ioannina, Ioannina, Greece
    Oncol Rep 17:1115-9. 2007
    ..05). No statistical difference was revealed by studying PDGFRalpha expression. In conclusion, our findings support the thesis of possible anti-PDGFRbeta anti-angiogenic therapy, in cases of endothelial PDGFRbeta-expressing breast cancer...
  32. ncbi Oligohydramnios decreases platelet-derived growth factor expression in fetal rat lungs
    Chung Ming Chen
    Department of Pediatrics, Taipei Medical University Hospital, Taipei, Taiwan
    Neonatology 92:187-93. 2007
    ..To evaluate the effects of experimental oligohydramnios on lung growth, expression of platelet-derived growth factor (PDGF) and its receptors, and lung morphology in fetal rats...
  33. pmc Angiotensin II stimulates phosphorylation of an ectodomain-truncated platelet-derived growth factor receptor-beta and its binding to class IA PI3K in vascular smooth muscle cells
    Ben Bo Gao
    Research Division, Joslin Diabetes Center, Harvard Medical School, Boston, MA 02215, USA
    Biochem J 397:337-44. 2006
    ..Our result suggests that the p70 PDGFR-beta functions as an adapter that recruits PI3K to the membrane upon AT1 receptor stimulation...
  34. ncbi Melittin, a major bioactive component of bee venom toxin, inhibits PDGF receptor beta-tyrosine phosphorylation and downstream intracellular signal transduction in rat aortic vascular smooth muscle cells
    Dong Ju Son
    College of Pharmacy and CBITRC, Chungbuk National University, Cheongju, Chungbuk, Republic of Korea
    J Toxicol Environ Health A 70:1350-5. 2007
    ....
  35. ncbi Constitutive diffuse activation of phosphoinositide 3-kinase at the plasma membrane by v-Src suppresses the chemotactic response to PDGF by abrogating the polarity of PDGF receptor signalling
    Anna Platek
    Universite Catholique de Louvain, Christian de Duve Institute of Cellular Pathology, CELL Unit, UCL 75 41, Avenue Hippocrate, 75, B 1200 Brussels, Belgium
    Exp Cell Res 313:1090-105. 2007
    ..Thus, PDGF can further increase PDGFR auto-phosphorylation despite strong Src kinase activity, but diffuse downstream activation of PI3-K by Src abrogates cell polarization and chemotaxis: "signalling requires silence"...
  36. ncbi A stroma targeted therapy enhances castration effects in a transplantable rat prostate cancer model
    Anna Johansson
    Department of Medical Bioscience, Pathology, Umea University, Sweden
    Prostate 67:1664-76. 2007
    ..We therefore used animal tumor models to explore the importance of stroma and vascular effects, and if castration effects could be enhanced by a simultaneous therapy targeting the tumor stroma...
  37. ncbi Crosstalk between angiotensin II and platelet derived growth factor-BB mediated signal pathways in cardiomyocytes
    Cheng Wang
    Department of Physiology and Pathophysiology and Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education, Peking University Health Science Center, Beijing 100083, China
    Chin Med J (Engl) 121:236-40. 2008
    ..Therefore, the crosstalk between AngII and PDGF-BB mediated signal pathways in the rat cardiomyocytes was investigated in this study...
  38. pmc Lysyl oxidase oxidizes cell membrane proteins and enhances the chemotactic response of vascular smooth muscle cells
    Hector A Lucero
    Department of Biochemistry, Boston University School of Medicine, 715 Albany Street, Boston, MA 02118, USA
    J Biol Chem 283:24103-17. 2008
    ..These novel findings suggest that LOX activity is essential to generate optimal chemotactic sensitivity of cells to chemoattractants by oxidizing specific cell surface proteins, such as PDGFR-beta...
  39. doi Gene transfer of redox factor-1 inhibits neointimal formation: involvement of platelet-derived growth factor-beta receptor signaling via the inhibition of the reactive oxygen species-mediated Syk pathway
    Hwan Myung Lee
    Institute of Medical Sciences, School of Medicine, Konkuk University, Chungju, South Korea
    Circ Res 104:219-27, 5p following 227. 2009
    ..These results indicate that Ref-1 inhibits the PDGF-mediated migration signal via the inhibition of reactive oxygen species-mediated Syk activity in RASMCs...
  40. doi Differential effects of red and white wines on inhibition of the platelet-derived growth factor receptor: impact of the mash fermentation
    Jan Sparwel
    Klinik III fur Innere Medizin, Universitat zu Koln, Germany
    Cardiovasc Res 81:758-70. 2009
    ..Platelet-derived growth factor (PDGF) is an important contributor to atherogenesis. We investigated the effects of selected red and white wines on PDGF receptor (PDGFR) signalling in rat and human vascular smooth muscle cells (VSMCs)...
  41. pmc Abelson tyrosine kinase links PDGFbeta receptor activation to cytoskeletal regulation of NMDA receptors in CA1 hippocampal neurons
    Michael A Beazely
    Department of Physiology, University of Toronto, ON, Canada
    Mol Brain 1:20. 2008
    ..The mechanism whereby PDGF receptor regulates cytoskeletal dynamics in central neurons remains poorly understood...
  42. pmc Platelet-derived growth factor selectively inhibits NR2B-containing N-methyl-D-aspartate receptors in CA1 hippocampal neurons
    Michael A Beazely
    Department of Physiology, University of Toronto, Toronto, Ontario M5S 1A8, Canada
    J Biol Chem 284:8054-63. 2009
    ..We conclude that PDGFbetaR signaling, by preferentially targeting NR2B receptors, provides an important mechanism for neuroprotection by growth factors in the central nervous system...
  43. pmc VEGFR2+PDGFRbeta+ circulating precursor cells participate in capillary restoration after hyperoxia acute lung injury (HALI)
    Rosemary Jones
    Department of Anesthesia and Critical Care, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    J Cell Mol Med 13:3720-9. 2009
    ..haematopoietic cells co-expressing vascular endothelial growth factor receptor 2 (VEGFR2) and platelet derived growth factor receptor beta (PDGFRbeta)...
  44. doi Potential roles of growth factor PDGF-BB in the bony repair of injured growth plate
    Rosa Chung
    Department of Orthopaedic Surgery, Women s and Children s Hospital, North Adelaide, Australia
    Bone 44:878-85. 2009
    ..These results suggest that PDGF-BB contributes to growth plate injury repair by promoting mesenchymal progenitor cell infiltration, the chondrogenic and osteogenic responses, and remodelling of the repair tissues...
  45. doi ROS and PDGF-beta [corrected] receptors are critically involved in indoxyl sulfate actions that promote vascular smooth muscle cell proliferation and migration
    Hidehisa Shimizu
    Graduate School of Life and Environment Sciences, Alliance for Research on North Africa, University of Tsukuba, Ibaraki, Japan
    Am J Physiol Cell Physiol 297:C389-96. 2009
    ....
  46. ncbi Effects of lipopolysaccharide on platelet-derived growth factor isoform and receptor expression in cultured rat common bile duct fibroblasts and cholangiocytes
    Tae Hyeon Kim
    Division of Gastroenterology, Department of Medicine, University of Washington and Veterans Affairs Puget Sound Health Care System, Seattle Division, Seattle, Washington 98195, USA
    J Gastroenterol Hepatol 24:1218-25. 2009
    ..We therefore sought to investigate whether exposure to bacterial lipopolysaccharide (LPS) alters PDGF isoform and receptor expression in cultured rat common bile duct fibroblasts (CBDF) and normal rat cholangiocytes (NRC)...
  47. doi Role of growth factor receptor transactivation in high glucose-induced increased levels of Gq/11alpha and signaling in vascular smooth muscle cells
    Magda Descorbeth
    Department of Physiology, University of Montreal, Montreal, Quebec, Canada
    J Mol Cell Cardiol 49:221-33. 2010
    ....
  48. doi Protein tyrosine phosphatase PTPepsilonM negatively regulates PDGF beta-receptor signaling induced by high glucose and PDGF in vascular smooth muscle cells
    Hidehisa Shimizu
    Graduate School of Life and Environmental Sciences, Alliance for Research on North Africa, University of Tsukuba, Ibaraki, Japan
    Am J Physiol Cell Physiol 299:C1144-52. 2010
    ..Therefore, PTPεM negatively regulates PDGFRβ-mediated signaling pathways that are crucial for the pathogenesis of atherosclerosis, and PTPεM may be involved in diabetes-accelerated atherosclerosis...
  49. ncbi Regulation of cell growth by redox-mediated extracellular proteolysis of platelet-derived growth factor receptor beta
    H Okuyama
    Department of Gastroenterological Surgery, Graduate School of Medicine, Kyoto University, Sakyo ku, Kyoto 606 8397, Japan
    J Biol Chem 276:28274-80. 2001
    ..These results indicated that redox processes impact the cell's response to growth factors by regulating the turnover of growth factor receptors and that "redox therapy" is promising for fibrosis-related disease...
  50. ncbi Ligand-independent trans-activation of the platelet-derived growth factor receptor by reactive oxygen species requires protein kinase C-delta and c-Src
    Shuichi Saito
    Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 0146, USA
    J Biol Chem 277:44695-700. 2002
    ....
  51. ncbi p73 independent of c-Myc represses transcription of platelet-derived growth factor beta-receptor through interaction with NF-Y
    Anders Hackzell
    Department of Cell Biology, Institute of Anatomy and Cell Biology, Goteborg University, Box 420, SE 405 30 Gothenburg, Sweden
    J Biol Chem 277:39769-76. 2002
    ..Our results indicate that serum stimulation induces c-Myc and p73alpha, leading to the down-regulation of PDGF beta-receptor expression by repressing its transcription...
  52. ncbi Enhancement of glomerular platelet-derived growth factor beta-receptor tyrosine phosphorylation in hypertensive rats and its inhibition by calcium channel blocker
    Yumei Zhan
    Department of Pharmacology, Osaka City University Medical School, Osaka, Japan
    Hypertens Res 25:295-301. 2002
    ....
  53. ncbi Expression of platelet-derived growth factor-A (PDGF-A), PDGF-B, and PDGF receptor-alpha and -beta during human testicular development and disease
    Sabrina Basciani
    Dipartimento di Fisiopatologia Medica, Universita di Roma La Sapienza, Policlinico Umberto I, 00161 Rome, Italy
    J Clin Endocrinol Metab 87:2310-9. 2002
    ..Finally, the expression of PDGF ligands and receptor proteins in Leydig cell tumors suggests a relationship of the PDGF system to tumorigenesis or tumor progression in this testicular neoplasm...
  54. ncbi Role of platelet-derived growth factor receptor-mediated signal transduction in myocardial hypertrophy of spontaneously hypertensive rats
    Jie Liu
    Department of Physiology and Pathophysiology, Peking University Health Science Center, Beijing 100083
    Sheng Li Xue Bao 54:159-64. 2002
    ..These findings suggest that PDGF beta receptor may play an important role in the myocardial hypertrophy of spontaneously hypertensive rats...
  55. pmc Platelet-derived growth factor-BB-mediated glycosaminoglycan synthesis is transduced through Akt
    Nicholas J Cartel
    Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada M5G 1L5
    Biochem J 363:19-28. 2002
    ..These data suggest that Akt is an integral protein involved in PDGF-BB-mediated GAG regulation in fetal lung fibroblasts...
  56. ncbi Effect of platelet-derived growth factor isoforms in rat metanephric mesenchymal cells
    Jill M Ricono
    Department of Medicine, University of Texas Health Science Center, San Antonio, Texas 78229 3900, USA
    Am J Physiol Renal Physiol 282:F211-9. 2002
    ..Collectively, the data may have implications related to the failure of PDGF AA to rescue mesangial cell phenotype in PDGF B-chain or PDGF-beta-receptor deficiency...
  57. ncbi PDGF-BB-mediated activation of p42(MAPK) is independent of PDGF beta-receptor tyrosine phosphorylation
    N J Cartel
    Canadian Institutes of Health Research Group in Lung Development, Programme in Lung Biology, Research Institute, Toronto, Ontario, Canada
    Am J Physiol Lung Cell Mol Physiol 281:L786-98. 2001
    ..These results suggest that PDGF-BB-mediated activation of p42(MAPK) requires the PDGFR-beta but is independent of its tyrosine phosphorylation...
  58. ncbi [A preliminary study on the changes of expression of PDGF-beta, PDGFR-beta, TGF-beta 1, TGFR, bFGF and its relationship with the wound age in wound healing]
    H J Wang
    Department of Forensic Pathology, First Military Medical University, Guangzhou 510515
    Fa Yi Xue Za Zhi 17:198-201, 204. 2001
    ..To explore the relationship between the expression change of cytokines and the wound age during the healing process of rats skin wound...
  59. ncbi Immunohistochemical characterization of glomerular PDGF B-chain and PDGF beta-receptor expression in diabetic rats
    H Nakagawa
    Third Department of Medicine, Shiga University of Medical Science, Seta, Otsu, Shiga, Japan
    Diabetes Res Clin Pract 48:87-98. 2000
    ..Our results suggest that the activation of the PDGF system in glomerular cells might play an important role in the development of early glomerular lesion in diabetes...
  60. ncbi Platelet-derived growth factor receptor beta regulates migration and DNA synthesis in metanephric mesenchymal cells
    M Arar
    Department of Pediatrics, South Texas Department of Veterans Affairs Health Care System, San Antonio, Texas 78229 3900, USA
    J Biol Chem 275:9527-33. 2000
    Platelet-derived growth factor (PDGF) B-chain and PDGF receptor beta (PDGFR beta) are essential for glomerulogenesis...
  61. pmc Role of PDGF B-chain and PDGF receptors in rat tubular regeneration after acute injury
    T Nakagawa
    Third Department of Medicine, Second Department of Pathology, Shiga University of Medical Science, Otsu, Japan
    Am J Pathol 155:1689-99. 1999
    ..These findings suggest that the PDGF-B/PDGFRs axis is involved in the proliferation of injured tubular cells and plays an important role in the regeneration of tubular cells from acute ischemic injury...
  62. ncbi Identification of a new quantitative trait locus on chromosome 7 controlling disease severity of collagen-induced arthritis in rats
    S V Dracheva
    Inflammatory Joint Diseases Section, Arthritis and Rheumatism Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bldg 10, Room 9N240, 10 Center Drive MSC 1820, Bethesda, MD 20892, USA
    Immunogenetics 49:787-91. 1999
    ....
  63. ncbi Quantitative trait loci disposing for both experimental arthritis and encephalomyelitis in the DA rat; impact on severity of myelin oligodendrocyte glycoprotein-induced experimental autoimmune encephalomyelitis and antibody isotype pattern
    I Dahlman
    Department of Medicine, Karolinska Hospital, Stockholm, Sweden
    Eur J Immunol 28:2188-96. 1998
    ..We conclude that Cia3 and Oia2 regulate MOG-induced EAE in rats. Furthermore, since both EAE and arthritis phenotypes co-localize to these gene regions, they may harbor genes which are key regulators of pathogenic immune responses...
  64. ncbi A genome scan localizes five non-MHC loci controlling collagen-induced arthritis in rats
    E F Remmers
    Inflammatory Joint Diseases Section, National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, Maryland 20892, USA
    Nat Genet 14:82-5. 1996
    ..These genes may also represent novel targets for therapy...
  65. ncbi Successive activation of the platelet-derived growth factor beta receptor and platelet-derived growth factor B genes correlates with the genesis of human choriocarcinoma
    L Holmgren
    Institute for Experimental Drug Research, Karolinska Hospital, Stockholm, Sweden
    Cancer Res 53:2927-31. 1993
    ....
  66. ncbi Blocking platelet-derived growth factor-D/platelet-derived growth factor receptor beta signaling inhibits human renal cell carcinoma progression in an orthotopic mouse model
    Lei Xu
    Edwin L Steele Laboratory, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    Cancer Res 65:5711-9. 2005
    ....
  67. ncbi A novel DNA vaccine encoding PDGFRbeta suppresses growth and dissemination of murine colon, lung and breast carcinoma
    Charles D Kaplan
    Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Vaccine 24:6994-7002. 2006
    ..Furthermore, this novel vaccine suppresses angiogenesis in vivo and reduces the numbers of tumor-associated, mPDGFRbeta-expressing pericytes as suggested by a decrease in intra-tumoral expression of mPDGFRbeta and NG2...
  68. ncbi PDGF and microvessel wall remodeling in adult lung: imaging PDGF-Rbeta and PDGF-BB molecules in progenitor smooth muscle cells developing in pulmonary hypertension
    Rosemary Jones
    Department of Anesthesia and Critical Care, Harvard Medical School and Massachusetts General Hospital, Boston, Massachusetts 02129, USA
    Ultrastruct Pathol 30:267-81. 2006
    ..In clear contrast to the RTK, constitutive expression levels of PDGF-BB were low in each progenitor cell type and remained restricted in the hypertensive lung...
  69. ncbi Comparative transcriptional and functional profiling of clear cell and papillary renal cell carcinoma
    Julia Diegmann
    Core Unit Chip Application CUCA, Institute of Human Genetics and Anthropology, Friedrich Schiller University, 07740 Jena, Germany
    Int J Mol Med 18:395-403. 2006
    ..Within these we found five surface marker genes to be upregulated (TNFRSF10B, CD70, TNFR1, PDGFRB, and BAFF) which are involved in immune responses via the regulation of lymphocytes and can also induce apoptosis...
  70. pmc Autocrine PDGFR signaling promotes mammary cancer metastasis
    Martin Jechlinger
    Research Institute for Molecular Pathology, Vienna, Austria
    J Clin Invest 116:1561-70. 2006
    ..Thus, autocrine PDGFR signaling plays an essential role during cancer progression, suggesting a novel application of STI571 to therapeutically interfere with metastasis...
  71. ncbi Conservation in sequence and affinity of human and rodent PDGF ligands and receptors
    B Herren
    Pharma Division, Preclinical Research, F Hoffmann La Roche, Basel, Switzerland
    Biochim Biophys Acta 1173:294-302. 1993
    ..Dissociation constants were identical to those of their human homologs. Thus, high affinity binding of human PDGF-BB to extracellular domains does not depend on species origin but only on receptor type...
  72. ncbi c-Src couples PI 3 kinase/Akt and MAPK signaling to PDGF-induced DNA synthesis in mesangial cells
    Goutam Ghosh Choudhury
    Department of Medicine, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA
    Cell Signal 18:1854-64. 2006
    ..Furthermore our results demonstrate that c-Src integrates signals into the nucleus to activate CDK2, which is required for DNA synthesis...
  73. ncbi Inhibition of PDGF beta-receptor tyrosine phosphorylation and its downstream intracellular signal transduction in rat aortic vascular smooth muscle cells by kaempferol
    Soo Yeon Kim
    College of Pharmacy, Chungbuk National University, Cheongju, Chungbuk, Korea
    Planta Med 71:599-603. 2005
    ....
  74. ncbi Expression patterns of PDGF-A, -B, -C and -D and the PDGF-receptors alpha and beta in activated rat hepatic stellate cells (HSC)
    Katja Breitkopf
    Department of Medicine II, Mol Alcohol Research in Gastroenterology, University Hospital Mannheim, University of Heidelberg, Theodor Kutzer Ufer 1 3, 68167 Mannheim, Germany
    Cytokine 31:349-57. 2005
    ..Given the dramatic changes in PDGF-C and -D expression, which may compensate for down-regulation of PDGF-B, we hypothesize that the new PDGF isoforms may fulfil specific functions in hepatic fibrogenesis...
  75. ncbi Identification and distribution of a novel platelet-derived growth factor receptor beta variant: effect of retinoic acid and involvement in cell differentiation
    Yan Wang
    Department of Biochemistry and Molecular and Cellular Biology, Georgetown University Medical Center, Washington, D C 20057, USA
    Endocrinology 148:2233-50. 2007
    ..These results suggest that the expression of V1-PDGFRbeta is tightly regulated during differentiation and that it may play an active role in germ cell differentiation...
  76. ncbi Expression and mutational analysis of tyrosine kinase receptors c-kit, PDGFRalpha, and PDGFRbeta in ovarian cancers
    Sharon P Wilczynski
    Department of Pathology, City of Hope National Medical Center, Duarte, CA 91010, USA
    Hum Pathol 36:242-9. 2005
    ..expression and mutational state for 3 TKRs (c-kit, platelet-derived growth factor receptor [PDGFR] alpha, and PDGFR beta) in ovarian cancer...
  77. ncbi A role for platelet-derived growth factor beta-receptor in a newborn rat model of endothelin-mediated pulmonary vascular remodeling
    Robert P Jankov
    Clinical Integrative Biology, Sunnybrook and Women s Research Institute, Toronto, Ontario, Canada
    Am J Physiol Lung Cell Mol Physiol 288:L1162-70. 2005
    ..Collectively, these data are consistent with a major role for PDGF-betaR-mediated SMC proliferation, acting downstream of increased ET-1 in a newborn rat model of 60% O2-induced pulmonary hypertension...
  78. ncbi Expression of platelet-derived growth factor in the developing cochlea of rats
    Yun Woo Lee
    The Auditory Molecular Biology Laboratory, Department of Otolaryngology, University of Minnesota, Minneapolis, MN, USA
    Acta Otolaryngol 124:558-62. 2004
    ..However, little is known about the expression of PDGF in the developing cochlea of rodents...
  79. ncbi Glomerular expression of platelet-derived growth factor (PDGF)-A, -B chain and PDGF receptor-alpha, -beta in human diabetic nephropathy
    Goro Uehara
    Division of Nephrology and Metabolism, Department of Internal Medicine, Tokai University School of Medicine, Bohseidai, Isehara, Kanagawa, 259 1193, Japan
    Clin Exp Nephrol 8:36-42. 2004
    ..The present study was designed to determine the expression of PDGF and PDF receptor (PDGFR) mRNA in the renal tissues of type 2 diabetic patients with DN...
  80. pmc Activation of Src kinase in platelet-derived growth factor-B-dependent tubular regeneration after acute ischemic renal injury
    Mikiko Takikita-Suzuki
    Department of Medicine, Shiga University of Medical Science, Seta, Otsu, Japan
    Am J Pathol 163:277-86. 2003
    ..These findings suggest that active Src participates in PDGF-B-dependent regeneration of tubular cells from acute ischemic injury...
  81. ncbi Pattern formation of vascular smooth muscle cells subject to nonuniform fluid shear stress: role of PDGF-beta receptor and Src
    Shu Q Liu
    Biomedical Engineering Department, E334, Technology Institute, Northwestern University, 2145 Sheridan Road, Evanston, IL 60208 3107, USA
    Am J Physiol Heart Circ Physiol 285:H1081-90. 2003
    ..These observations suggest that PDGF-beta receptor and Src possibly serve as mediating factors in nonuniform shear-induced formation of cell density gradients and alignment of SMCs in the neointima of vascular polymer implants...
  82. ncbi Prenatal exposure to estrogenic compounds alters the expression pattern of platelet-derived growth factor receptors alpha and beta in neonatal rat testis: identification of gonocytes as targets of estrogen exposure
    Raphael Thuillier
    Division of Hormone Research, Department of Cell Biology, Georgetown University School of Medicine, Washington, District of Columbia 20057, USA
    Biol Reprod 68:867-80. 2003
    ..These results, however, do not exclude the possibility that the effects of the compounds examined in this study might be due to estrogen receptor-independent action(s)...

Research Grants4

  1. Effects of intracellular angiotensin II
    Julia Cook; Fiscal Year: 2009
    ..abstract_text> ..
  2. PHOSPHORYLATION IN RENAL CELL INJURY
    Goutam Ghosh Choudhury; Fiscal Year: 2004
    ..These studies will identify important signaling mechanisms involved in glomerular pathology and help to establish effective therapeutic modalities for treatment of proliferative forms of GN. ..
  3. Fi02 and Blood Vessel Formation in Adult Lung
    Rosemary Jones; Fiscal Year: 2006
    ....
  4. The Role of Tuberin in Smooth Muscle Cell Proliferation
    Geraldine Finlay; Fiscal Year: 2007
    ..abstract_text> ..