Pdgfb

Summary

Gene Symbol: Pdgfb
Description: platelet-derived growth factor beta polypeptide
Alias: SIS, c-sis, PDGF subunit B, PDGF-2, Platelet-derived growth factor, same as Sis (Simian sarcoma viral oncogene homologue, c-sis), pdgf protein, platelet derived growth factor, B polypeptide, platelet-derived growth factor B chain, platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog), platelet-derived growth factor subunit B
Species: rat

Top Publications

  1. pmc HIV-1 Tat-mediated induction of platelet-derived growth factor in astrocytes: role of early growth response gene 1
    Crystal Bethel-Brown
    Department of Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City, KS 66160, USA
    J Immunol 186:4119-29. 2011
  2. doi Platelet-derived growth factor BB promotes the migration of bone marrow-derived mesenchymal stem cells towards C6 glioma and up-regulates the expression of intracellular adhesion molecule-1
    Peng Cheng
    Department of Neurosurgery, The First Affiliated Hospital, China Medical University, Nanjingbei Street, No 151, Heping District, Shenyang, Liaoning Province 110001, PR China
    Neurosci Lett 451:52-6. 2009
  3. pmc The effects of PTK787/ZK222584, an inhibitor of VEGFR and PDGFRβ pathways, on intussusceptive angiogenesis and glomerular recovery from Thy1.1 nephritis
    Monika Wnuk
    Department of Nephrology and Hypertension, Inselspital, University of Bern Medical School, Bern, Switzerland
    Am J Pathol 178:1899-912. 2011
  4. pmc Hypoxia-inducible factor-1 α/platelet derived growth factor axis in HIV-associated pulmonary vascular remodeling
    Joel Mermis
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Kansas Medical Center, Kansas City, USA
    Respir Res 12:103. 2011
  5. pmc Platelet-derived growth factor-mediated induction of the synaptic plasticity gene Arc/Arg3.1
    Fuwang Peng
    Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, Nebraska 68198 5880, USA
    J Biol Chem 285:21615-24. 2010
  6. pmc PDGF-BB and TGF-{beta}1 on cross-talk between endothelial and smooth muscle cells in vascular remodeling induced by low shear stress
    Ying Xin Qi
    Institute of Mechanobiology and Medical Engineering, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, China
    Proc Natl Acad Sci U S A 108:1908-13. 2011
  7. ncbi Production of platelet derived growth factor B chain (PDGF-B/c-sis) mRNA and immunoreactive PDGF B-like polypeptide by rheumatoid synovium: coexpression with heparin binding acidic fibroblast growth factor-1
    E F Remmers
    Arthritis and Rheumatism Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892
    J Rheumatol 18:7-13. 1991
  8. ncbi Platelet-derived growth factor-BB and Ets-1 transcription factor negatively regulate transcription of multiple smooth muscle cell differentiation marker genes
    Frederic Dandre
    Cardiovascular Research Center, University of Virginia, PO Box 801394, Charlottesville, VA 22908 1394, USA
    Am J Physiol Heart Circ Physiol 286:H2042-51. 2004
  9. ncbi Imatinib mesylate reduces production of extracellular matrix and prevents development of experimental dermal fibrosis
    Jörg H W Distler
    University of Erlangen Nuremberg, Erlangen, Germany
    Arthritis Rheum 56:311-22. 2007
  10. ncbi Blood lipid mediator sphingosine 1-phosphate potently stimulates platelet-derived growth factor-A and -B chain expression through S1P1-Gi-Ras-MAPK-dependent induction of Kruppel-like factor 5
    Soichiro Usui
    Department of Molecular and Cellular Physiology, Kanazawa University Graduate School of Medical Sciences, 13 1 Takara machi, Kanazawa, Ishikawa 920 8640, Japan
    J Biol Chem 279:12300-11. 2004

Research Grants

Scientific Experts

Detail Information

Publications79

  1. pmc HIV-1 Tat-mediated induction of platelet-derived growth factor in astrocytes: role of early growth response gene 1
    Crystal Bethel-Brown
    Department of Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City, KS 66160, USA
    J Immunol 186:4119-29. 2011
    ..Because astrogliosis is linked to disease severity, understanding its regulation by PDGF-BB could aid in the development of therapeutic intervention strategies for HAND...
  2. doi Platelet-derived growth factor BB promotes the migration of bone marrow-derived mesenchymal stem cells towards C6 glioma and up-regulates the expression of intracellular adhesion molecule-1
    Peng Cheng
    Department of Neurosurgery, The First Affiliated Hospital, China Medical University, Nanjingbei Street, No 151, Heping District, Shenyang, Liaoning Province 110001, PR China
    Neurosci Lett 451:52-6. 2009
    ....
  3. pmc The effects of PTK787/ZK222584, an inhibitor of VEGFR and PDGFRβ pathways, on intussusceptive angiogenesis and glomerular recovery from Thy1.1 nephritis
    Monika Wnuk
    Department of Nephrology and Hypertension, Inselspital, University of Bern Medical School, Bern, Switzerland
    Am J Pathol 178:1899-912. 2011
    ..Collectively, treatment of nephritic patients with PTK/ZK compound is not recommended...
  4. pmc Hypoxia-inducible factor-1 α/platelet derived growth factor axis in HIV-associated pulmonary vascular remodeling
    Joel Mermis
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Kansas Medical Center, Kansas City, USA
    Respir Res 12:103. 2011
    ..In this study, we explored the impact of HIV protein induced oxidative stress on production of hypoxia inducible factor (HIF)-1α and platelet-derived growth factor (PDGF), critical mediators implicated in the pathogenesis of HIV-PAH...
  5. pmc Platelet-derived growth factor-mediated induction of the synaptic plasticity gene Arc/Arg3.1
    Fuwang Peng
    Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, Nebraska 68198 5880, USA
    J Biol Chem 285:21615-24. 2010
    ..Chromatin immunoprecipitation assays demonstrated the binding of Egr-1, but not Egr-3, to the Arc promoter. These findings for the first time, thus, suggest an additional role of PDGF, that of induction of Arc...
  6. pmc PDGF-BB and TGF-{beta}1 on cross-talk between endothelial and smooth muscle cells in vascular remodeling induced by low shear stress
    Ying Xin Qi
    Institute of Mechanobiology and Medical Engineering, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, China
    Proc Natl Acad Sci U S A 108:1908-13. 2011
    ..PDGF-BB is involved in the paracrine control of VSMCs by ECs, whereas TGF-β1 participates in the feedback control from VSMCs to ECs...
  7. ncbi Production of platelet derived growth factor B chain (PDGF-B/c-sis) mRNA and immunoreactive PDGF B-like polypeptide by rheumatoid synovium: coexpression with heparin binding acidic fibroblast growth factor-1
    E F Remmers
    Arthritis and Rheumatism Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892
    J Rheumatol 18:7-13. 1991
    ..PDGF B/c-sis mRNA transcripts were detected in synovium from patients with rheumatoid arthritis (RA) (n = 5)...
  8. ncbi Platelet-derived growth factor-BB and Ets-1 transcription factor negatively regulate transcription of multiple smooth muscle cell differentiation marker genes
    Frederic Dandre
    Cardiovascular Research Center, University of Virginia, PO Box 801394, Charlottesville, VA 22908 1394, USA
    Am J Physiol Heart Circ Physiol 286:H2042-51. 2004
    ..Taken together, results of these experiments provide novel insights regarding possible mechanisms whereby PDGF-BB and Ets-1 may contribute to SMC phenotypic switching associated with vascular injury...
  9. ncbi Imatinib mesylate reduces production of extracellular matrix and prevents development of experimental dermal fibrosis
    Jörg H W Distler
    University of Erlangen Nuremberg, Erlangen, Germany
    Arthritis Rheum 56:311-22. 2007
    ..This study was undertaken to test the potential use of imatinib mesylate as an antifibrotic drug for the treatment of dermal fibrosis in systemic sclerosis (SSc)...
  10. ncbi Blood lipid mediator sphingosine 1-phosphate potently stimulates platelet-derived growth factor-A and -B chain expression through S1P1-Gi-Ras-MAPK-dependent induction of Kruppel-like factor 5
    Soichiro Usui
    Department of Molecular and Cellular Physiology, Kanazawa University Graduate School of Medical Sciences, 13 1 Takara machi, Kanazawa, Ishikawa 920 8640, Japan
    J Biol Chem 279:12300-11. 2004
    ..These results reveal the S1P(1)-triggered, G(i)-Ras-ERK/p38 MAPK-KLF5-dependent, stimulatory regulation of PDGF gene transcription in vascular smooth muscle cells...
  11. ncbi Role of protein kinase C on the expression of platelet-derived growth factor and endothelin-1 in the retina of diabetic rats and cultured retinal capillary pericytes
    Tamotsu Yokota
    Research Division, Joslin Diabetes Center, Harvard Medical School, One Joslin Place, Boston, MA 02215, USA
    Diabetes 52:838-45. 2003
    ..The novel demonstration of elevated expression of PDGF-B and its induction by PKC activation identifies a potential new molecular step in the pathogenesis of diabetic retinopathy...
  12. pmc Simultaneous changes in high-fat and high-cholesterol diet-induced steatohepatitis and severe fibrosis and those underlying molecular mechanisms in novel SHRSP5/Dmcr rat
    Takashi Moriya
    Department of Occupational and Environmental Health, Nagoya University Graduate School of Medicine, Tsurumai cho, Showa Ku, Nagoya, Aichi, Japan
    Environ Health Prev Med 17:444-56. 2012
    ....
  13. doi Snail mediates PDGF-BB-induced invasion of rat bone marrow mesenchymal stem cells in 3D collagen and chick chorioallantoic membrane
    Changlian Lu
    College of Pharmacy, Harbin Medical University, Harbin, China
    J Cell Physiol 228:1827-33. 2013
    ..Finally, snail controls MSC transmigration through chorioallantoic membrane of 11-day-old chick embryos. Taken together, these in vitro and in vivo data identify snail as a critical mediator for rBMMSC invasion induced by PDGF-BB...
  14. doi Crosstalk between platelet-derived growth factor-induced Nox4 activation and MUC8 gene overexpression in human airway epithelial cells
    Hyun Jik Kim
    Department of Otolaryngology Head and Neck Surgery, Chung Ang University College of Medicine, Seoul, Korea
    Free Radic Biol Med 50:1039-52. 2011
    ..PDGF and Nox4 overexpression are essential components of intracellular ROS generation and may contribute to chronic inflammation in the nasal epithelium through induction of MUC8 overexpression...
  15. doi Innate immunity, through late complement components activation, contributes to the development of early vascular inflammation and morphologic alterations in experimental diabetes
    F Fischetti
    Department of Medical, Technological and Translational Sciences, University of Trieste, Italy
    Atherosclerosis 216:83-9. 2011
    ..To verify if innate immunity, and namely the assembly of terminal complement complex (TCC) could be involved in the development of early diabetic vascular damage...
  16. ncbi [The effect of angiotensin-(1-7) on the mRNA expression of PDGF and TGF-beta1 in the kidney of diabetic rats]
    Shuo Ping Chen
    Department of Endocrinology, The Affiliated No 1 Hospital of Wenzhou Medical College, Wenzhou 325000, China
    Zhongguo Ying Yong Sheng Li Xue Za Zhi 24:475-8. 2008
    ..To study the effect of angiotensin-(1-7) on the kidney of diabetic rats by observing the mRNA expression of PDGF and TGF-beta1...
  17. doi Fra-2 transgenic mice as a novel model of pulmonary hypertension associated with systemic sclerosis
    Britta Maurer
    Department of Rheumatology, University Hospital of Zurich, Zurich, Switzerland
    Ann Rheum Dis 71:1382-7. 2012
    ..In this study, the authors evaluated fos-related antigen 2 (Fra-2) transgenic mice as a novel model for systemic sclerosis-associated pulmonary arterial hypertension...
  18. doi Adenosine monophosphate-activated protein kinase regulates platelet-derived growth factor-BB-induced vascular smooth muscle cell migration
    Miki Iida
    Department of Anesthesiology and Pain Medicine, Gifu University Graduate School of Medicine, Yanagido 1 1, Gifu 501 1194, Japan
    Arch Biochem Biophys 530:83-92. 2013
    ..In conclusion, our results strongly suggest that PDGF-BB induces activation of AMPK in VSMCs, and subsequently regulates the migration via both the p44/p42 MAP kinase pathway and the PI3-kinase/Akt pathway...
  19. doi Hepatic stimulator substance alleviates toxin-induced and immune-mediated liver injury and fibrosis in rats
    Xuerui Yi
    Key Laboratory of Liver Disease, Center of Infectious Diseases, Guangzhou 458 Hospital, Dongfengdonglu 801, Guangzhou 510600, Guangdong, China
    Dig Dis Sci 57:2079-87. 2012
    ..It is a precursor to cirrhosis and liver carcinoma. Hepatic stimulator substance (HSS), a known liver-specific but species-nonspecific growth factor, has been shown to protect hepatocytes from various toxins...
  20. doi Soluble angiogenic factors in patients with acute pancreatitis
    Laura Espinosa
    Servicio de Aparato Digestivo, Hospital Universitario La Princesa, Instituto de Investigación Sanitaria Princesa, Madrid, Spain
    J Clin Gastroenterol 45:630-7. 2011
    ..Angiogenic factors are involved in the physiopathology of several inflammatory diseases and they probably play a role in the pathogenesis of acute pancreatitis (AP)...
  21. doi Chrysin restores PDGF-induced inhibition on protein tyrosine phosphatase and reduces PDGF signaling in cultured VSMCs
    Huey Ming Lo
    School of Medicine, Fu Jen Catholic University, Hsinchuang, Taipei 24205, Taiwan
    J Nutr Biochem 23:667-78. 2012
    ..In conclusion, we provide here evidence that chrysin can regulate intracellular PTP activity during PDGF signaling, inhibits PDGF-induced VSMC proliferation and chemotaxis, and reduces arterial intima hyperplasia in vivo...
  22. pmc Platelet-derived growth factor-BB induces renal tubulointerstitial myofibroblast formation and tubulointerstitial fibrosis
    W W Tang
    Department of Anatomic and Experimental Pathology, Amgen Inc, Thousand Oaks, California 91320, USA
    Am J Pathol 148:1169-80. 1996
    ..These data suggest that PDGF-BB may be an important mediator of tubulointerstitial hyperplasia and fibrosis...
  23. doi Combined VEGF and PDGF treatment reduces secondary degeneration after spinal cord injury
    Cameron Lutton
    Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia
    J Neurotrauma 29:957-70. 2012
    ....
  24. doi Mycophenolic acid inhibits the autocrine PDGF-B synthesis and PDGF-BB-induced mRNA expression of Egr-1 in rat mesangial cells
    Danuta Sabuda-Widemann
    Department for Nephrology, Heinrich Heine Universitat, Dusseldorf, Germany
    Nephrol Dial Transplant 24:52-61. 2009
    ..MPA was tested on the expression of platelet-derived growth factor-B (PDGF-B) and its receptor beta (PDGFR-beta), the immediate early gene (IEG) c-fos and the early growth response gene-1 (Egr-1), and AP-1 activation...
  25. doi Peritoneal morphological and functional changes associated with platelet-derived growth factor B
    Davide Cina
    Department of Medicine, McMaster University, Hamilton, ON, Canada
    Nephrol Dial Transplant 24:448-57. 2009
    ..Platelet-derived growth factor (PDGF) has been associated with all of these phenomena, and is a prototypical 'response to injury' growth factor...
  26. doi Notch signaling regulates platelet-derived growth factor receptor-beta expression in vascular smooth muscle cells
    Shaobo Jin
    Department of Cell and Molecular Biology, Medical Nobel Institute, Karolinska Institute, Stockholm, Sweden
    Circ Res 102:1483-91. 2008
    ..In sum, these data reveal a hierarchy for 2 important signaling systems, Notch and PDGF, in the vasculature and provide insights into how dysregulated Notch signaling perturbs VSMC differentiation and function...
  27. pmc Molecular mechanisms linking wound inflammation and fibrosis: knockdown of osteopontin leads to rapid repair and reduced scarring
    Ryoichi Mori
    Department of Physiology, School of Medical Sciences, University of Bristol, Bristol BS8 1TD, UK
    J Exp Med 205:43-51. 2008
    ..Thus, OPN and PDGF are potential targets for therapeutic modulation of skin repair to improve healing rate and quality...
  28. pmc PYK2 signaling is required for PDGF-dependent vascular smooth muscle cell proliferation
    Jessica Perez
    Department of Cell Biology, University of Alabama at Birmingham, Alabama, USA
    Am J Physiol Cell Physiol 301:C242-51. 2011
    ..These data suggest that PYK2 is an important upstream mediator in PDGF-dependent signaling cascades that regulate VSMC proliferation...
  29. ncbi Up-regulation of platelet-derived growth factor by peripheral-blood leukocytes during experimental allergic encephalomyelitis
    Niklas K U Koehler
    Department of Neurology, Hannover Medical School, Hannover, Germany
    J Neurosci Res 86:392-402. 2008
    ..The production of PDGF by lymphocytes may have potential therapeutic value when activating or modulating T-cell responses in demyelinating diseases...
  30. ncbi Comparison of molecular determinants of angiogenesis and lymphangiogenesis in lymph node metastases and in primary tumours of patients with breast cancer
    G G Van den Eynden
    Translational Cancer Research Group at Laboratory of Pathology, University of Antwerp University Hospital Antwerp, Wilrijk, B 2610 Antwerp, Belgium
    J Pathol 213:56-64. 2007
    ..001) and FGF2 (p = 0.008) were decreased and the expression levels of VEGFA (p = 0.01) and PDGFB (p = 0.002) were increased compared to uninvolved LNs...
  31. ncbi Reversal of portal hypertension and hyperdynamic splanchnic circulation by combined vascular endothelial growth factor and platelet-derived growth factor blockade in rats
    Mercedes Fernandez
    Hepatic Hemodynamic Laboratory, Liver Unit, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, Hospital Clinic, CIBERehd, Universitat de Barcelona, Barcelona, Spain
    Hepatology 46:1208-17. 2007
    ..Portosystemic collateralization was reduced as well...
  32. ncbi [Effect of ischemia preconditioning on pro- and anti- angiogenic molecule expression and functional arteries formation]
    Yong Wang
    Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan 430060, China
    Zhonghua Xin Xue Guan Bing Za Zhi 38:819-22. 2010
    ..to observe the effect of ischemia preconditioning (IPC) on the expression of pro-angiogenic VEGF, PDGF and anti-angiogenic ADAMTS-1, and arteriogenesis...
  33. ncbi [Effect of signal transducer and activator of transcription 1 antisense oligodeoxynucleotides on inflammatory mediators, type I and type III collagen mRNA of rat pulmonary fibrosis]
    Wen Jun Wang
    Department of Respiratory Medicine, Affiliated Hospital of Luzhou Medical College, China
    Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 25:389-92. 2009
    ....
  34. doi Inhibitory effects of adiponectin on platelet-derived growth factor-induced mesangial cell migration
    Keisuke Ishizawa
    Departments of Pharmacology, Clinical Pharmacy Medical Pharmacology, The University of Tokushima Graduate School, The Institute of Health Bioscience, 3 18 15 Kuramoto, Tokushima, Japan
    J Endocrinol 202:309-16. 2009
    ..From these findings, it is implied that the elevated plasma adiponectin levels in patients with CKD might play a compensatory role aimed at counteracting renal dysfunction related to MC disorders...
  35. ncbi Effects of lipopolysaccharide on platelet-derived growth factor isoform and receptor expression in cultured rat common bile duct fibroblasts and cholangiocytes
    Tae Hyeon Kim
    Division of Gastroenterology, Department of Medicine, University of Washington and Veterans Affairs Puget Sound Health Care System, Seattle Division, Seattle, Washington 98195, USA
    J Gastroenterol Hepatol 24:1218-25. 2009
    ..We therefore sought to investigate whether exposure to bacterial lipopolysaccharide (LPS) alters PDGF isoform and receptor expression in cultured rat common bile duct fibroblasts (CBDF) and normal rat cholangiocytes (NRC)...
  36. pmc Platelet-derived growth factor mediates survival of leukemic large granular lymphocytes via an autocrine regulatory pathway
    Jun Yang
    Penn State Hershey Cancer Institute, Department of Medicine, College of Medicine, Pennsylvania State University, Hershey, PA, USA
    Blood 115:51-60. 2010
    ..These results suggest that targeting of PDGF-BB, a pivotal regulator for the long-term survival of leukemic LGLs, may be an important therapeutic strategy...
  37. doi Down-regulation of CREB-binding protein expression inhibits thrombin-induced proliferation of endothelial cells: possible relevance to PDGF-B
    Hong Jiang
    Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan 430060, Peoples Republic of China
    Cell Biol Int 34:1155-61. 2010
    ..This inhibitory effect was, in part, related to the inability to up-regulate PDGF-B expression in ECs. CBP could be regarded as a potential therapeutic target for vascular injury...
  38. ncbi Traumatic spinal cord injury alters angiogenic factors and TGF-beta1 that may affect vascular recovery
    Marie Françoise Ritz
    Department of Biomedicine, Brain Tumor Biology, Pharmacenter, Klingelbergstrasse 50, 4056 Basel, Switzerland
    Curr Neurovasc Res 7:301-10. 2010
    ..These findings should be considered in order to improve therapeutic interventions...
  39. doi Tenascin-C enhances crosstalk signaling of integrin αvβ3/PDGFR-β complex by SRC recruitment promoting PDGF-induced proliferation and migration in smooth muscle cells
    Tomoki Ishigaki
    Department of Pathology and Matrix Biology, Graduate School of Medicine, Mie University, Tsu, Mie, Japan
    J Cell Physiol 226:2617-24. 2011
    ..In the cells on TNC substrate, crosstalk signaling between integrin αvβ3 and PDGFR-β could be amplified by SRC and FAK recruited to focal adhesions, followed by enhanced proliferation and migration of A10 cells by PDGF-BB...
  40. ncbi [Effects of jiawei huzhang san decoction on the expressions of inflammatory factors MCP-1 and PDGF-BB in rat models of experimental autoimmune prostatitis]
    Qing Zhou
    Department of Surgery, The First Affiliated Hospital of Hunan University of Chinese Medicine, Changsha, Hunan 410007, China
    Zhonghua Nan Ke Xue 17:83-8. 2011
    ....
  41. pmc Platelet-derived growth factor-BB-mediated glycosaminoglycan synthesis is transduced through Akt
    Nicholas J Cartel
    Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada M5G 1L5
    Biochem J 363:19-28. 2002
    ..These data suggest that Akt is an integral protein involved in PDGF-BB-mediated GAG regulation in fetal lung fibroblasts...
  42. pmc Different profiles of Ca2+ responses to endothelin-1 and PDGF in liver myofibroblasts during the process of cell differentiation
    N Kojima
    Department of Veterinary Pharmacology, Graduate School of Agriculture and Life Sciences, The University of Tokyo, Bunkyo ku, Tokyo, Japan
    Br J Pharmacol 151:816-27. 2007
    ..In this study, intracellular Ca(2+) concentration ([Ca(2+)](i)) was measured to assess the response to endothelin-1 (ET-1), platelet derived growth factor (PDGF) and ATP in rat liver myofibroblasts...
  43. ncbi Oligohydramnios decreases platelet-derived growth factor expression in fetal rat lungs
    Chung Ming Chen
    Department of Pediatrics, Taipei Medical University Hospital, Taipei, Taiwan
    Neonatology 92:187-93. 2007
    ..To evaluate the effects of experimental oligohydramnios on lung growth, expression of platelet-derived growth factor (PDGF) and its receptors, and lung morphology in fetal rats...
  44. ncbi Lycopene binds PDGF-BB and inhibits PDGF-BB-induced intracellular signaling transduction pathway in rat smooth muscle cells
    Huey Ming Lo
    School of Medicine, Fu Jen Catholic University, Taipei County, Taiwan
    Biochem Pharmacol 74:54-63. 2007
    ..The results presented here may help us to better understand the beneficial effects of lycopene in CVD prevention...
  45. ncbi Sources of PDGF expression in murine retina and the effect of short-term diabetes
    Orla T Cox
    Ophthalmology Vision Science, Queen s University of Belfast, Institute of Clinical Science, Royal Victoria Hospital Belfast, Northern Ireland
    Mol Vis 9:665-72. 2003
    ..The retinal cell source(s) of PDGF remain unknown. It is important to understand how diabetes alters expression of this important growth factor...
  46. pmc Activation of Src kinase in platelet-derived growth factor-B-dependent tubular regeneration after acute ischemic renal injury
    Mikiko Takikita-Suzuki
    Department of Medicine, Shiga University of Medical Science, Seta, Otsu, Japan
    Am J Pathol 163:277-86. 2003
    ..These findings suggest that active Src participates in PDGF-B-dependent regeneration of tubular cells from acute ischemic injury...
  47. ncbi Hypertension increases expression of growth factors and MHC II in chronic allograft nephropathy
    Ralf Schindler
    Department of Nephrology and Internal Intensive Care Medicine, Universitatsklinikum Charite, Campus Virchow Klinikum, Humboldt University, Berlin, Germany
    Kidney Int 63:2302-8. 2003
    ..Hypertension of the recipient is strongly associated with chronic allograft nephropathy. It is unclear, however, whether hypertension is the cause or the consequence of chronic allograft nephropathy...
  48. ncbi Dermatofibrosarcoma protuberans of the vulva and groin: detection of COL1A1-PDGFB fusion transcripts by RT-PCR
    Neriman Gokden
    Lauren V Ackerman Laboratory of Surgical Pathology, Barnes Jewish Hospital, Washington University Medical Center, St Louis, MO, USA
    J Cutan Pathol 30:190-5. 2003
    ..results in the fusion of two genes, collagen type I alpha 1(COL1A1) and platelet-derived growth factor B-chain (PDGFB)...
  49. ncbi [A preliminary study on the changes of expression of PDGF-beta, PDGFR-beta, TGF-beta 1, TGFR, bFGF and its relationship with the wound age in wound healing]
    H J Wang
    Department of Forensic Pathology, First Military Medical University, Guangzhou 510515
    Fa Yi Xue Za Zhi 17:198-201, 204. 2001
    ..To explore the relationship between the expression change of cytokines and the wound age during the healing process of rats skin wound...
  50. ncbi N-Ethylmaleimide inhibits platelet-derived growth factor BB-stimulated Akt phosphorylation via activation of protein phosphatase 2A
    Chandrahasa R Yellaturu
    Department of Physiology and Center for Vascular Biology, The University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA
    J Biol Chem 277:40148-55. 2002
    ..NAC also attenuated the apoptosis induced by NEM, alone or in combination with PDGF-BB. Together, these findings demonstrate for the first time that PP2A mediates thiol alkylation-dependent redox regulation of Akt and cell survival...
  51. ncbi Novel regulation of adrenomedullin receptor by PDGF: role of receptor activity modifying protein-3
    Wojciech Nowak
    Department of Physiology, Michigan State University, East Lansing, Michigan 48824, USA
    Am J Physiol Cell Physiol 282:C1322-31. 2002
    ..Taken together, these data identify PDGF-dependent regulation of RAMP-3 expression as a possible mechanism for modulating the responsiveness of the mesangial cell to AM...
  52. ncbi Expression of platelet-derived growth factor-A (PDGF-A), PDGF-B, and PDGF receptor-alpha and -beta during human testicular development and disease
    Sabrina Basciani
    Dipartimento di Fisiopatologia Medica, Universita di Roma La Sapienza, Policlinico Umberto I, 00161 Rome, Italy
    J Clin Endocrinol Metab 87:2310-9. 2002
    ..Finally, the expression of PDGF ligands and receptor proteins in Leydig cell tumors suggests a relationship of the PDGF system to tumorigenesis or tumor progression in this testicular neoplasm...
  53. ncbi von Hippel-Lindau tumor suppressor protein represses platelet-derived growth factor B-chain gene expression via the Sp1 binding element in the proximal PDGF-B promoter
    Louise A Rafty
    Centre for Thrombosis and Vascular Research, University of New South Wales, Australia
    J Cell Biochem 85:490-5. 2002
    ..We show that Sp1 can rescue PDGF-B promoter activity and endogenous PDGF-B mRNA expression from pVHL repression. These findings thus demonstrate a pivotal role for Sp1 in pVHL inhibition of PDGF-B transcription...
  54. ncbi Determination of cytokine mRNA-expression in term human placenta of patients with gestational hypertension, intrauterine growth retardation and gestational diabetes mellitus using polymerase chain reaction
    J Heinig
    Biochemical Institute of the University of Rostock
    Zentralbl Gynakol 122:413-8. 2000
    ....
  55. pmc Role of PDGF B-chain and PDGF receptors in rat tubular regeneration after acute injury
    T Nakagawa
    Third Department of Medicine, Second Department of Pathology, Shiga University of Medical Science, Otsu, Japan
    Am J Pathol 155:1689-99. 1999
    ..These findings suggest that the PDGF-B/PDGFRs axis is involved in the proliferation of injured tubular cells and plays an important role in the regeneration of tubular cells from acute ischemic injury...
  56. ncbi Successive activation of the platelet-derived growth factor beta receptor and platelet-derived growth factor B genes correlates with the genesis of human choriocarcinoma
    L Holmgren
    Institute for Experimental Drug Research, Karolinska Hospital, Stockholm, Sweden
    Cancer Res 53:2927-31. 1993
    ....
  57. ncbi Increased expression of PDGF A- and B-chain genes in rat lungs with hypoxic pulmonary hypertension
    D Katayose
    First Department of Internal Medicine, Tohoku University School of Medicine, Miyagi, Japan
    Am J Physiol 264:L100-6. 1993
    ..These results suggest that the PDGF A- and B-chain products may be coordinately and sequentially involved in hypoxic pulmonary vascular remodeling...
  58. ncbi Conservation in sequence and affinity of human and rodent PDGF ligands and receptors
    B Herren
    Pharma Division, Preclinical Research, F Hoffmann La Roche, Basel, Switzerland
    Biochim Biophys Acta 1173:294-302. 1993
    ..Dissociation constants were identical to those of their human homologs. Thus, high affinity binding of human PDGF-BB to extracellular domains does not depend on species origin but only on receptor type...
  59. ncbi mRNA expression of growth factors in glomeruli from diabetic rats
    T Nakamura
    Department of Medicine and Biochemistry, Juntendo University School of Medicine, Tokyo, Japan
    Diabetes 42:450-6. 1993
    ..These data indicate that alterations in growth factor mRNA levels in glomeruli may be a manifestation of diabetic nephropathy, and that hyperglycemia or insulin deficiency may play a role in abnormal growth factor gene regulation...
  60. ncbi Estrogen regulates insulin-like growth factor 1, platelet-derived growth factor A and B, and their receptors in the vascular wall
    Hanna Savolainen-Peltonen
    Transplantation Laboratory and Rational Drug Design Programme, Biomedicum, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland
    Transplantation 77:35-42. 2004
    ..Estrogen provides vasculoprotective effects by regulating endothelial and vascular SMC function...
  61. ncbi The PDGF B-chain is involved in the ontogenic susceptibility of the developing rat brain to NMDA toxicity
    Tomoko Egawa-Tsuzuki
    Department of Pediatrics, Shiga University of Medical Science, Shiga, Japan
    Exp Neurol 186:89-98. 2004
    ..Enhancement of the PDGF-B/receptor signal pathway might rescue neonatal brains at risk of H-I injury...
  62. ncbi Platelet-derived growth factor regulates cytomegalovirus infection-enhanced obliterative bronchiolitis in rat tracheal allografts
    Jussi M Tikkanen
    Cardiopulmonary Research Group, Transplantation Laboratory, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland
    Transplantation 77:655-8. 2004
    ..Cytomegalovirus (CMV) infection is a risk factor for the development of obliterative bronchiolitis (OB) after lung transplantation...
  63. ncbi [Modulation of expression of platelet-derived growth factor by nuclear transcription factor-kappaB in rats retina]
    Bin Mo
    Tongren Eye Center, Capital University of Medical Sciences, Beijing, China
    Zhonghua Yan Ke Za Zhi 43:49-54. 2007
    ....
  64. ncbi Expression patterns of PDGF-A, -B, -C and -D and the PDGF-receptors alpha and beta in activated rat hepatic stellate cells (HSC)
    Katja Breitkopf
    Department of Medicine II, Mol Alcohol Research in Gastroenterology, University Hospital Mannheim, University of Heidelberg, Theodor Kutzer Ufer 1 3, 68167 Mannheim, Germany
    Cytokine 31:349-57. 2005
    ..Given the dramatic changes in PDGF-C and -D expression, which may compensate for down-regulation of PDGF-B, we hypothesize that the new PDGF isoforms may fulfil specific functions in hepatic fibrogenesis...
  65. ncbi Antioxidants relieve phosphatase inhibition and reduce PDGF signaling in cultured VSMCs and in restenosis
    Kai Kappert
    Department of Oncology Pathology, Karolinska Institutet, 17176 Stockholm, Sweden
    Arterioscler Thromb Vasc Biol 26:2644-51. 2006
    ....
  66. ncbi PDGF and microvessel wall remodeling in adult lung: imaging PDGF-Rbeta and PDGF-BB molecules in progenitor smooth muscle cells developing in pulmonary hypertension
    Rosemary Jones
    Department of Anesthesia and Critical Care, Harvard Medical School and Massachusetts General Hospital, Boston, Massachusetts 02129, USA
    Ultrastruct Pathol 30:267-81. 2006
    ..In clear contrast to the RTK, constitutive expression levels of PDGF-BB were low in each progenitor cell type and remained restricted in the hypertensive lung...
  67. ncbi Glutaredoxin modulates platelet-derived growth factor-dependent cell signaling by regulating the redox status of low molecular weight protein-tyrosine phosphatase
    Munetake Kanda
    Department of Biochemistry and Molecular Biology in Disease, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki 852 8523, Japan
    J Biol Chem 281:28518-28. 2006
    ..Thus, GRX plays an important role in PDGF-BB-dependent cell proliferation by regulating the redox state of LMW-PTP...
  68. ncbi Possible predictive markers related to micro-metastasis in breast cancer patients
    Li Zhu
    Hung Chao Hong Integrated Centre for Breast Diseases, Department of Surgery, The University of Hong Kong, Hong Kong, PR China
    Oncol Rep 15:1217-23. 2006
    ..017), whereas VEGF overexpression predicts only the presence of SLN micro-metastasis by IHC (P=0.001). Our results indicate the possible value of using these markers to predict the risk of micro-metastasis in breast cancer...
  69. ncbi A carboxyl-terminal determinant of the neuronal glutamate transporter, EAAC1, is required for platelet-derived growth factor-dependent trafficking
    Amanda L Sheldon
    Department of Pediatrics, Children s Hospital of Philadelphia, University of Pennsylvania, Philadelphia, Pennsylvania 19104 4318, USA
    J Biol Chem 281:4876-86. 2006
    ..These studies identify a novel motif within the carboxyl terminus of EAAC1 which is required for regulated trafficking. The possibility that this motif targets EAAC1 to an intracellular, "regulated pool" is discussed...
  70. ncbi Expression and functional analysis of platelet-derived growth factor in uterine leiomyomata
    Minglin Liang
    Department of Obstetrics and Gynecology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
    Cancer Biol Ther 5:28-33. 2006
    ..To examine the expression of PDGF and its receptors in leiomyoma tissue and to investigate the regulation of PDGF on leiomyoma cell proliferation...
  71. ncbi [Effects of quercetin and enalapril on amount of PDGF-B and VEGF-1 in kidney of diabetic rats]
    Hui Huang
    Department of Endocrinology, West China Hospital, Sichuan University, Chengdu 610041, China
    Sheng Wu Yi Xue Gong Cheng Xue Za Zhi 22:791-4. 2005
    ..The protective role of Quercetin and Enalapril in lowering urinary protein excretion may be related to the decreased amounts of PDGF-B and VEGF-1 in renal tissue...
  72. ncbi Characterization of intracellular pathways leading to coinduction of thrombospondin-1 and TGF-beta1 expression in rat hepatic stellate cells
    Katja Breitkopf
    Mol Alcohol Research in Gastroenterology, Department of Medicine II, University Hospital Mannheim, University of Heidelberg, Mannheim, Germany
    Growth Factors 23:77-85. 2005
    ..In summary the data illustrate specific pathways activated by PDGF-BB and TNF-a in HSC giving new insights into the tightly controlled mechanisms regulating TSP-1 and TGF-beta1 expression in these cells...
  73. ncbi Hypoxia regulates PDGF-B interactions between glomerular capillary endothelial and mesangial cells
    Eudora Eng
    Division of Nephrology and Hypertension, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
    Kidney Int 68:695-703. 2005
    ..We examined the impact of hypoxia on PDGF-B-mediated interactions between glomerular endothelial and mesangial cells, a condition of potential relevance in developing, and diseased adult, kidneys...
  74. ncbi Blockade of nuclear factor of activated T cells activation signaling suppresses balloon injury-induced neointima formation in a rat carotid artery model
    Zhimin Liu
    Department of Physiology, University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA
    J Biol Chem 280:14700-8. 2005
    ..Together these results for the first time demonstrate that NFATs play a critical role in neointima formation via induction of expression of COX-2...
  75. ncbi Glomerular expression of platelet-derived growth factor (PDGF)-A, -B chain and PDGF receptor-alpha, -beta in human diabetic nephropathy
    Goro Uehara
    Division of Nephrology and Metabolism, Department of Internal Medicine, Tokai University School of Medicine, Bohseidai, Isehara, Kanagawa, 259 1193, Japan
    Clin Exp Nephrol 8:36-42. 2004
    ..The present study was designed to determine the expression of PDGF and PDF receptor (PDGFR) mRNA in the renal tissues of type 2 diabetic patients with DN...
  76. ncbi A subpopulation of smooth muscle cells in injured rat arteries expresses platelet-derived growth factor-B chain mRNA
    V Lindner
    University of Washington, Department of Pathology, Seattle 98195, USA
    Circ Res 76:951-7. 1995
    ....
  77. ncbi A role for platelet-derived growth factor-BB in rat postpneumonectomy compensatory lung growth
    Shizeng Yuan
    Lung Biology Programme, Hospital for Sick Children Research Institute, Toronto, Ontario, Canada
    Pediatr Res 52:25-33. 2002
    ..These findings are consistent with a critical role for PDGF-BB in postpneumonectomy lung growth...
  78. doi Potential roles of growth factor PDGF-BB in the bony repair of injured growth plate
    Rosa Chung
    Department of Orthopaedic Surgery, Women s and Children s Hospital, North Adelaide, Australia
    Bone 44:878-85. 2009
    ..These results suggest that PDGF-BB contributes to growth plate injury repair by promoting mesenchymal progenitor cell infiltration, the chondrogenic and osteogenic responses, and remodelling of the repair tissues...

Research Grants2

  1. TGF-B IN RENAL ENDOTHELIAL & MESANGIAL CELL DEVELOPMENT
    Eudora Eng; Fiscal Year: 2002
    ..By immunohistochemistry and electron microscopy, effects of diminished endothelial PDGF-B on mesangial cells will be determined. ..
  2. Fi02 and Blood Vessel Formation in Adult Lung
    Rosemary Jones; Fiscal Year: 2006
    ....