Pax6

Summary

Gene Symbol: Pax6
Description: paired box 6
Alias: paired box protein Pax-6, oculorhombin, paired box gene 6, paired box homeotic gene 6
Species: rat

Top Publications

  1. ncbi Pax6 is required for production and maintenance of progenitor cells in postnatal hippocampal neurogenesis
    Motoko Maekawa
    Division of Developmental Neuroscience, Center for Translational and Advanced Animal Research CTAAR, Tohoku University School of Medicine, 2 1 Seiryo machi, Aoba ku, Sendai 980 8575, Japan
    Genes Cells 10:1001-14. 2005
  2. pmc PAX6 haplotypes are associated with high myopia in Han chinese
    Bo Jiang
    Department of Ophthalmology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
    PLoS ONE 6:e19587. 2011
  3. doi Association of PAX6 polymorphisms with high myopia in Han Chinese nuclear families
    Wei Han
    Department of Ophthalmology, The First Affiliated Hospital, Medical College, Zhejiang University, Hangzhou, China
    Invest Ophthalmol Vis Sci 50:47-56. 2009
  4. ncbi Pax-6 is involved in the specification of hindbrain motor neuron subtype
    N Osumi
    Department of Developmental Biology, Graduate School of Dentistry, Tokyo Medical and Dental University, Bunkyo ku, Japan
    Development 124:2961-72. 1997
  5. doi Concise review: Pax6 transcription factor contributes to both embryonic and adult neurogenesis as a multifunctional regulator
    Noriko Osumi
    Division of Developmental Neuroscience, Center for Translational and Advanced Animal Research, Tohoku University School of Medicine, 2 1, Seiryo machi, Aoba ku, Sendai 980 8575, Japan
    Stem Cells 26:1663-72. 2008
  6. ncbi Role of Fabp7, a downstream gene of Pax6, in the maintenance of neuroepithelial cells during early embryonic development of the rat cortex
    Yoko Arai
    Division of Developmental Neuroscience, Department of Functional Genomics, Center for Translational and Advanced Animal Research, Tohoku University School of Medicine, Sendai 980 8575, Japan
    J Neurosci 25:9752-61. 2005
  7. ncbi Overexpression of PAX6(5a) in lens fiber cells results in cataract and upregulation of (alpha)5(beta)1 integrin expression
    M K Duncan
    Department of Biological Sciences, University of Delaware, Newark, DE 19716, USA
    J Cell Sci 113:3173-85. 2000
  8. ncbi Pax6 regulates granule cell polarization during parallel fiber formation in the developing cerebellum
    T Yamasaki
    Department of Biophysics, Graduate School of Science, Kyoto University, Japan
    Development 128:3133-44. 2001
  9. ncbi Pax6 regulates specification of ventral neurone subtypes in the hindbrain by establishing progenitor domains
    Masanori Takahashi
    Department of Developmental Neurobiology, Tohoku University Graduate School of Medicine, 2 1, Seiryo machi, Aoba ku, Sendai 980 8575, Japan
    Development 129:1327-38. 2002
  10. ncbi Variable phenotype related to a novel PAX 6 mutation (IVS4+5G>C) in a family presenting congenital nystagmus and foveal hypoplasia
    Marie Claire Vincent
    Service de Genetique Medicale, CHU de Toulouse Hôpital Purpan, Toulouse, France
    Am J Ophthalmol 138:1016-21. 2004

Scientific Experts

Detail Information

Publications65

  1. ncbi Pax6 is required for production and maintenance of progenitor cells in postnatal hippocampal neurogenesis
    Motoko Maekawa
    Division of Developmental Neuroscience, Center for Translational and Advanced Animal Research CTAAR, Tohoku University School of Medicine, 2 1 Seiryo machi, Aoba ku, Sendai 980 8575, Japan
    Genes Cells 10:1001-14. 2005
    ..b>Pax6 transcription factor is a key player for patterning the brain and promoting embryonic neurogenesis, and is also ..
  2. pmc PAX6 haplotypes are associated with high myopia in Han chinese
    Bo Jiang
    Department of Ophthalmology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
    PLoS ONE 6:e19587. 2011
    The paired box 6 (PAX6) gene is considered as a master gene for eye development...
  3. doi Association of PAX6 polymorphisms with high myopia in Han Chinese nuclear families
    Wei Han
    Department of Ophthalmology, The First Affiliated Hospital, Medical College, Zhejiang University, Hangzhou, China
    Invest Ophthalmol Vis Sci 50:47-56. 2009
    The paired box 6 (PAX6) gene is critical to eye development. Based on prior linkage evidence, this study was conducted to investigate the association of PAX6 polymorphisms with high myopia in a Han Chinese population.
  4. ncbi Pax-6 is involved in the specification of hindbrain motor neuron subtype
    N Osumi
    Department of Developmental Biology, Graduate School of Dentistry, Tokyo Medical and Dental University, Bunkyo ku, Japan
    Development 124:2961-72. 1997
    ..These results strongly suggest that Pax-6 is involved in the specification of subtypes of hindbrain motor neurons, presumably through the regulation of Islet-2 and Wnt-7b expression...
  5. doi Concise review: Pax6 transcription factor contributes to both embryonic and adult neurogenesis as a multifunctional regulator
    Noriko Osumi
    Division of Developmental Neuroscience, Center for Translational and Advanced Animal Research, Tohoku University School of Medicine, 2 1, Seiryo machi, Aoba ku, Sendai 980 8575, Japan
    Stem Cells 26:1663-72. 2008
    b>Pax6 is a highly conserved transcription factor among vertebrates and is important in various developmental processes in the central nervous system (CNS), including patterning of the neural tube, migration of neurons, and formation of ..
  6. ncbi Role of Fabp7, a downstream gene of Pax6, in the maintenance of neuroepithelial cells during early embryonic development of the rat cortex
    Yoko Arai
    Division of Developmental Neuroscience, Department of Functional Genomics, Center for Translational and Advanced Animal Research, Tohoku University School of Medicine, Sendai 980 8575, Japan
    J Neurosci 25:9752-61. 2005
    b>Pax6 is a transcription factor with key functional roles in the developing brain...
  7. ncbi Overexpression of PAX6(5a) in lens fiber cells results in cataract and upregulation of (alpha)5(beta)1 integrin expression
    M K Duncan
    Department of Biological Sciences, University of Delaware, Newark, DE 19716, USA
    J Cell Sci 113:3173-85. 2000
    The PAX6 gene, a key regulator of eye development, produces two major proteins that differ in paired domain structure: PAX6 and PAX6(5a)...
  8. ncbi Pax6 regulates granule cell polarization during parallel fiber formation in the developing cerebellum
    T Yamasaki
    Department of Biophysics, Graduate School of Science, Kyoto University, Japan
    Development 128:3133-44. 2001
    ..In Pax6 mutant rats (rSey2/rSey2), granule cells in the external germinal layer (EGL) fail to form parallel fiber axons and ..
  9. ncbi Pax6 regulates specification of ventral neurone subtypes in the hindbrain by establishing progenitor domains
    Masanori Takahashi
    Department of Developmental Neurobiology, Tohoku University Graduate School of Medicine, 2 1, Seiryo machi, Aoba ku, Sendai 980 8575, Japan
    Development 129:1327-38. 2002
    ..b>Pax6 is a HD protein that has previously been shown to be involved in the differentiation of the hindbrain somatic (SM) ..
  10. ncbi Variable phenotype related to a novel PAX 6 mutation (IVS4+5G>C) in a family presenting congenital nystagmus and foveal hypoplasia
    Marie Claire Vincent
    Service de Genetique Medicale, CHU de Toulouse Hôpital Purpan, Toulouse, France
    Am J Ophthalmol 138:1016-21. 2004
    Several ocular defects have been identified as a consequence of the PAX6 gene mutations...
  11. ncbi Subpial neuronal migration in the medulla oblongata of Pax-6-deficient rats
    Masao Horie
    Department of Developmental Morphology, Tokyo Metropolitan Institute for Neuroscience, Fuchu 183 8526, Japan
    Eur J Neurosci 17:49-57. 2003
    ....
  12. pmc A novel PAX6 mutation in a large Chinese family with aniridia and congenital cataract
    Fucheng Cai
    Pediatrics Department of Union Hospital, Huazhong University of Science and Technology, Wuhan, Hubei, China
    Mol Vis 16:1141-5. 2010
    ..To identify the disease-causing gene in a four-generation Chinese family affected with autosomal dominant aniridia and cataract...
  13. pmc R-cadherin is a Pax6-regulated, growth-promoting cue for pioneer axons
    Gracie L Andrews
    Department of Biology, Cell and Molecular Biology Graduate Program, University of Nevada, Reno, Nevada 89557, USA
    J Neurosci 23:9873-80. 2003
    The transcription factor Pax6 has been implicated in two processes that may be related in brain development: establishment of regional cell adhesion properties and axon guidance...
  14. ncbi A mutation in the Pax-6 gene in rat small eye is associated with impaired migration of midbrain crest cells
    T Matsuo
    Department of Ophthalmology, Okayama University Medical School, Japan
    Nat Genet 3:299-304. 1993
    ....
  15. pmc PAX6 aniridia and interhemispheric brain anomalies
    Hana Abouzeid
    Jules Gonin Eye Hospital, University of Lausanne, Switzerland
    Mol Vis 15:2074-83. 2009
    ..To report the clinical and genetic study of patients with autosomal dominant aniridia...
  16. doi The expression of neuroepithelial cell fate determinants in rat spinal cord development
    Beverley M Henley
    Department of Anatomy, Biosciences Institute, University College Cork, Cork, Ireland
    J Mol Neurosci 42:28-34. 2010
    ..indicates that the combination of transcription factors of the basic helix-loop-helix (Hes3, Hes5) and homeodomain (Pax6) families establish molecular codes that determine both the timing and position of neurons and glia...
  17. pmc Dopamine receptor activation promotes adult neurogenesis in an acute Parkinson model
    Beate Winner
    Department of Neurology, University of Regensburg, Universitaetsstr 84, 93053 Regensburg, Germany
    Exp Neurol 219:543-52. 2009
    ..in vitro, and PPX specifically increased mRNA levels of epidermal growth factor receptor (EGF-R) and paired box gene 6 (Pax6)...
  18. doi Corneal epithelial-like transdifferentiation of hair follicle stem cells is mediated by pax6 and beta-catenin/Lef-1
    Ke Yang
    Department of Cell Biology, Third Military Medical University, Gaotanyan, Chongqing 400038, PR China
    Cell Biol Int 33:861-6. 2009
    ..The transdifferentiation depends on upregulation of pax6 and downregulation of beta-catenin and Lef-1...
  19. doi Histopathological characterisation of effects of the mouse Pax6(Leca4) missense mutation on eye development
    Thaya Ramaesh
    Division of Reproductive and Developmental Sciences, Genes and Development Group, University of Edinburgh, George Square, Edinburgh EH8 9XD, Scotland, UK
    Exp Eye Res 89:263-73. 2009
    Mutations in PAX6/Pax6 lead to a variety of ocular anomalies in humans and mice...
  20. pmc High-fat diet induced insulin resistance in pregnant rats through pancreatic pax6 signaling pathway
    Hao Wu
    Department of Obstetrics and Gyencology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine Shanghai, China
    Int J Clin Exp Pathol 8:5196-202. 2015
    ..To explore the changes in pancreas islet function of pregnant rats after consumption of high-fat diet and the underlying mechanism...
  21. doi Paired box 6 (PAX6) regulates glucose metabolism via proinsulin processing mediated by prohormone convertase 1/3 (PC1/3)
    J H Wen
    Peking University Stem Cell Research Center, China Australian Center of Excellence for Stem Cell Sciences, Beijing, People s Republic of China
    Diabetologia 52:504-13. 2009
    Human patients with aniridia caused by heterozygous PAX6 mutations display abnormal glucose metabolism, but the underlying molecular mechanism is largely unknown...
  22. pmc Prenatal exposure of ethanol induces increased glutamatergic neuronal differentiation of neural progenitor cells
    Ki Chan Kim
    Department of Pharmacology, College of Pharmacy, Seoul National University, Seoul, Korea
    J Biomed Sci 17:85. 2010
    ....
  23. doi Altered gene expression in rat cranial neural crest cells exposed to a teratogenic glucose concentration in vitro: paradoxical downregulation of antioxidative defense genes
    Parri Wentzel
    Department of Medical Cell Biology, Uppsala University, Biomedical Center, Sweden
    Birth Defects Res B Dev Reprod Toxicol 92:487-97. 2011
    ..We aimed to study glucose-induced alterations of mRNA levels in cranial and trunk NCCs isolated from rat embryos with increased risk of developing mandibular and cardiac malformations in diabetic pregnancy...
  24. pmc A splice site mutation in the PAX6 gene which induces exon skipping causes autosomal dominant inherited aniridia
    Nicole Weisschuh
    Centre for Ophthalmology, Institute for Ophthalmic Research, Molecular Genetics Laboratory, Tuebingen, Germany
    Mol Vis 18:751-7. 2012
    ..To identify the underlying genetic cause in a two generation German family diagnosed with isolated aniridia...
  25. pmc Mutation analysis of PAX6 in inherited and sporadic aniridia from northeastern China
    Yang Kang
    Department of Ophthalmology, First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China
    Mol Vis 18:1750-4. 2012
    Haplo-insufficiency at the paired box gene 6 (PAX6) locus causes aniridia,which is characterized by iris hypoplasia and other anterior and posterior eye defects leading to poor vision...
  26. pmc Association of paired box 6 with high myopia in Japanese
    Masahiro Miyake
    Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Mol Vis 18:2726-35. 2012
    The objective of this study was to investigate whether genetic variations in the paired box 6 (PAX6) gene are associated with high myopia in Japanese subjects.
  27. doi Müller glia cells activation in rat retina after optic nerve injury: spatiotemporal correlation with transcription initiation factor IIb
    Yue Xu
    Department of Ophthalmology, Affiliated Hospital of Nantong University, Nantong, Jiangsu Province, 226001, People s Republic of China
    J Mol Neurosci 51:37-46. 2013
    ..In addition, we also examined the expression of the retinal progenitor markers (Nestin and Pax6) whose changes were correlated with the expression of TFIIB...
  28. doi Pax6-dependent cortical glutamatergic neuronal differentiation regulates autism-like behavior in prenatally valproic acid-exposed rat offspring
    Ki Chan Kim
    Department of Pharmacology, College of Pharmacy, Seoul National University, Seoul, South Korea
    Mol Neurobiol 49:512-28. 2014
    ..Transcription factor Pax6, implicated in glutamatergic neuronal differentiation, was transiently increased in embryonic cortex by valproate ..
  29. ncbi Transcription factor Pax6 is expressed by astroglia after transient brain ischemia in the rat model
    Aleksandra Steliga
    Przemysław Kowiański, MD, PhD, Department of Anatomy and Neurobiology, Medical University of Gdansk, 1 Debinki Street, 80 211 Gdansk, Poland, phone 48 58 349 14 01, fax 48 58 349 14 21, E mail
    Folia Neuropathol 51:203-13. 2013
    ..b>Pax6 transcription factor is one of the characteristic markers of astroglial de-differentiation, also important for ..
  30. doi Cloning, expression, and functional characterization of the rat Pax6 5a orthologous splicing variant
    Fei Wei
    Department of Neurology, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, China Electronic address
    Gene 547:169-74. 2014
    b>Pax6 functions as a pleiotropic regulator in eye development and neurogenesis. Its splice variant Pax6 5a has been cloned in many vertebrate species including human and mouse, but never in rat...
  31. doi Glucose modulates Pax6 expression through the JNK/p38 MAP kinase pathway in pancreatic beta-cells
    Sivasangari Balakrishnan
    Department of Biochemistry, Bharathidasan University, Tiruchirappalli 620 024, India
    Life Sci 109:1-7. 2014
    The paired and homeodomain-containing transcription factor, paired box 6 (Pax6), has shown to play pivotal roles in beta-cell function, including cell survival, insulin biosynthesis and secretion...
  32. pmc Mutation of the PAX6 gene in patients with autosomal dominant keratitis
    F Mirzayans
    Department of Ophthalmology, University of Alberta, Edmonton, Canada
    Am J Hum Genet 57:539-48. 1995
    ..Aniridia (shown recently to result from mutations in the PAX6 gene) has overlapping clinical findings and a similar pattern of inheritance with ADK...
  33. pmc Overexpression of Pax6 results in microphthalmia, retinal dysplasia and defective retinal ganglion cell axon guidance
    Martine Manuel
    Genes and Development Group, Centres for Integrative Physiology and Neuroscience Research, Hugh Robson Building, George Square, University of Edinburgh, Edinburgh EH8 9XD, UK
    BMC Dev Biol 8:59. 2008
    The transcription factor Pax6 is expressed by many cell types in the developing eye. Eyes do not form in homozygous loss-of-function mouse mutants (Pax6Sey/Sey) and are abnormally small in Pax6Sey/+ mutants...
  34. ncbi Cranial anomaly of homozygous rSey rat is associated with a defect in the migration pathway of midbrain crest cells
    N Osumi-Yamashita
    Department of Developmental Biology, Graduate School of Dentistry, Tokyo Medical and Dental University, Japan
    Dev Growth Differ 39:53-67. 1997
    ..Therefore, the cranial defects in rSey homozygous embryos are due to inappropriate substrate for crest cell migration towards the lateral nasal prominence, which consistently explains the cranial morphology of homozygous rSey embryos...
  35. ncbi Misrouting of mitral cell progenitors in the Pax6/small eye rat telencephalon
    Tadashi Nomura
    Division of Developmental Neuroscience, Tohoku University Graduate School of Medicine, 2 1, Seiryo machi, Aoba ku, Sendai 980 8575, Japan
    Development 131:787-96. 2004
    The olfactory bulb is a protruding structure formed at the rostral end of the telencephalon. Pax6-mutant mice and rats lack the olfactory bulb and, instead, develop an olfactory bulb-like structure at the lateral part of the telencephalon...
  36. ncbi Aberrant lens fiber differentiation in anterior subcapsular cataract formation: a process dependent on reduced levels of Pax6
    Frank J Lovicu
    Save Sight Institute, Department of Anatomy and Histology, Institute for Biomedical Research, University of Sydney, NSW, Australia
    Invest Ophthalmol Vis Sci 45:1946-53. 2004
    ..To understand further the events associated with the onset and progression of TGFbeta-induced cataract, several different models for anterior subcapsular cataract (ASC) were used and characterized...
  37. ncbi Developmental and cellular factors underlying corneal epithelial dysgenesis in the Pax6+/- mouse model of aniridia
    Thaya Ramaesh
    Division of Reproductive and Developmental Sciences, Genes and Development Group, University of Edinburgh, Hugh Robson Building, George Square, Edinburgh EH8 9XD, UK
    Exp Eye Res 81:224-35. 2005
    Heterozygosity for a PAX6 deficiency (PAX6+/-) results in low levels of the PAX6 transcription factor and causes aniridia...
  38. ncbi Three novel Pax6 alleles in the mouse leading to the same small-eye phenotype caused by different consequences at target promoters
    Jochen Graw
    Institute of Developmental Genetics, GSF National Research Center for Environment and Health, Neuherberg, Germany
    Invest Ophthalmol Vis Sci 46:4671-83. 2005
    ..To characterize three new mouse small-eye mutants detected during ethylnitrosourea mutagenesis programs...
  39. doi Developmental and daily expression of the Pax4 and Pax6 homeobox genes in the rat retina: localization of Pax4 in photoreceptor cells
    Martin F Rath
    Department of Neuroscience and Pharmacology, Panum Institute, University of Copenhagen, Copenhagen, Denmark
    J Neurochem 108:285-94. 2009
    ..In the pancreas, Pax4 counters the effects of the related transcription factor, Pax6, which is known to be essential for eye morphogenesis...
  40. doi Reduced proliferation and excess astrogenesis of Pax6 heterozygous neural stem/progenitor cells
    Nobuyuki Sakayori
    Division of Developmental Neuroscience, United Centers for Advanced Research and Translational Medicine ART, Tohoku University Graduate School of Medicine, 2 1 Seiryo machi, Aoba ku, Sendai 980 8575, Japan
    Neurosci Res 74:116-21. 2012
    ..A transcription factor Pax6 is a pivotal player in various neurodevelopmental processes...
  41. doi Pax6 is a key component of regulated glucagon secretion
    Yvan Gosmain
    Diabetes Unit, University Hospital, University of Geneva Medical School, 1211 Geneva 14, Switzerland
    Endocrinology 153:4204-15. 2012
    The Pax6 transcription factor is crucial for pancreatic α-cells. Indeed, Pax6-deficient mouse models are characterized by markedly altered α-cell differentiation...
  42. doi Pax6 is crucial for β-cell function, insulin biosynthesis, and glucose-induced insulin secretion
    Yvan Gosmain
    Diabetes Unit, Division of Endocrinology, Diabetes, and Nutrition, University Hospital, University of Geneva Medical School, 1211 Geneva 14, Switzerland
    Mol Endocrinol 26:696-709. 2012
    The Pax6 transcription factor is crucial for endocrine cell differentiation and function. Indeed, mutations of Pax6 are associated with a diabetic phenotype and a drastic decrease of insulin-positive cell number...
  43. pmc Modification of pax6 and olig2 expression in adult hippocampal neurogenesis selectively induces stem cell fate and alters both neuronal and glial populations
    Friederike Klempin
    Department of Neuroscience, The Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, IL, USA
    Stem Cells 30:500-9. 2012
    ..Using an in vivo retroviral delivery and lineage tracing approach, we compare the lineage-instruction factors, Pax6 and Olig2, and demonstrate that both participate in regulation of adult hippocampal neurogenesis in adult rats...
  44. ncbi Expression of the transcription factor Pax 6 in the adult rat dentate gyrus
    Juan Nacher
    Neurobiology, Cell Biology Department, Universitat de Valencia, Burjassot, Spain
    J Neurosci Res 81:753-61. 2005
    ..However, the expression of Pax 6 in astrocytes and certain mature neurons may indicate the existence of other roles for this transcription factor in this telencephalic region...
  45. pmc The incidence of PAX6 mutation in patients with simple aniridia: an evaluation of mutation detection in 12 cases
    R Axton
    MRC Human Genetics Unit, Western General Hospital, Edinburgh, UK
    J Med Genet 34:279-86. 1997
    ..test what proportion of people with aniridia, uncomplicated by associated anomalies, carry mutations in the human PAX6 gene. Mutations were detected in 90% of the cases...
  46. ncbi Functional PAX-6 gene-linked polymorphic region: potential association with paranoid schizophrenia
    G Stober
    Department of Psychiatry, University of Wurzburg, Germany
    Biol Psychiatry 45:1585-91. 1999
    ....
  47. pmc Missense mutation in the alternative splice region of the PAX6 gene in eye anomalies
    N Azuma
    Department of Ophthalmology, National Children s Hospital, Tokyo 154 8509, Japan
    Am J Hum Genet 65:656-63. 1999
    The PAX6 gene is involved in ocular morphogenesis, and PAX6 mutations have been detected in various types of ocular anomalies, including aniridia, Peters anomaly, corneal dystrophy, congenital cataract, and foveal hypoplasia...
  48. ncbi Novel target sequences for Pax-6 in the brain-specific activating regions of the rat aldolase C gene
    Henriette Skala-Rubinson
    Département de génétique, Developpement et Pathologie Moleculaire, Institut Cochin, INSERM, CNRS, Universite Rene Descartes, 24, rue du Faubourg Saint Jacques, 75014 Paris, France
    J Biol Chem 277:47190-6. 2002
    ..This result suggests that the brain-specific aldolase C gene could constitute a new target for the transcription factor Pax-6, which is implicated increasingly in neurogenesis...
  49. pmc Mutations of the PAX6 gene detected in patients with a variety of optic-nerve malformations
    Noriyuki Azuma
    Department of Ophthalmology, National Center for Child Health and Development, Tokyo, Japan
    Am J Hum Genet 72:1565-70. 2003
    The PAX6 gene is involved in ocular morphogenesis and is expressed in the developing central nervous system and numerous ocular tissues during development...
  50. doi The homeodomain of PAX6 is essential for PAX6-dependent activation of the rat glucagon gene promoter: evidence for a PH0-like binding that induces an active conformation
    Marcel Grapp
    Department of Molecular Pharmacology, University of Gottingen, Gottingen, Germany
    Biochim Biophys Acta 1789:403-12. 2009
    The transcription factor PAX6 plays an important role in transcriptional regulation of the peptide hormone glucagon from pancreatic alpha-cells. PAX6 contains two DNA binding domains, the paired domain (PD) and the homeodomain (HD)...
  51. ncbi PAX6 is expressed in pancreatic adenocarcinoma and is downregulated during induction of terminal differentiation
    Deborah Lang
    Section of Dermatology, Department of Medicine, University of Chicago, Chicago, Illinois, USA
    Mol Carcinog 47:148-56. 2008
    ..We find 32/46 (70%) of primary tumors and 9/10 (90%) of cell lines express PAX6. PAX6 is a transcription factor expressed throughout the pancreatic bud during embryogenesis but not in the mature ..
  52. pmc Pax6 guides a relay of pioneer longitudinal axons in the embryonic mouse forebrain
    Hikmet F Nural
    Biochemistry Graduate Program, and Biology Department, University of Nevada, Reno, Nevada 89557, USA
    J Comp Neurol 479:399-409. 2004
    ..To start a genetic analysis of pioneer axon guidance, we have identified the transcription factor Pax6 as critical for tract formation...
  53. ncbi Study of Pax6 mutant rat revealed the association between upper incisor formation and midface formation
    Rungarun Kriangkrai
    Section of Molecular Craniofacial Embryology, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
    Dev Dyn 235:2134-43. 2006
    In this study, we investigated the process of supernumerary upper incisor formation in the Pax6 mutant rat, rSey(2)/rSey(2), which exhibits a facial cleft between the medial nasal and maxillary processes...
  54. pmc Pax6 expression is sufficient to induce a neurogenic fate in glial progenitors of the neonatal subventricular zone
    Eun Sook Jang
    Integrated CMBS and Pathology Graduate Programs, Columbia University, New York, New York, United States of America
    PLoS ONE 6:e20894. 2011
    ..or stabilized in this mixed population is not clear, although previous studies indicate the importance of two transcription factors, Pax6 in neurons and Olig2 in glia, and suggest there may be reciprocal repression between these genes.
  55. ncbi Pax6 transcription factor is required for the interkinetic nuclear movement of neuroepithelial cells
    Hiroshi Tamai
    Division of Developmental Neuroscience, Center for Translational and Advanced Animal Research, Tohoku University School of Medicine, 2 1, Seiryo machi, Aoba ku, Sendai 980 8575, Japan
    Genes Cells 12:983-96. 2007
    ..b>Pax6 transcription factor plays pivotal roles in various aspects of corticogenesis...
  56. doi Pax6 regulates boundary-cell specification in the rat hindbrain
    Masanori Takahashi
    Division of Developmental Neuroscience, United Centers for Advanced Research and Translational Medicine ART, Graduate School of Medicine, Tohoku University, Seiryo machi, Aoba ku, Sendai, Miyagi, Japan
    Mech Dev 128:289-302. 2011
    ..In this study, we report that Pax6, a homeodomain transcription factor, regulates boundary-cell specification between rhombomeres of the developing ..
  57. doi Proneural transcription factors Dlx2 and Pax6 are altered in adult SVZ neural precursor cells following striatal cell loss
    Kathryn S Jones
    Department of Pharmacology and Clinical Pharmacology, Centre for Brain Research, Faculty of Medical and Health Sciences, University of Auckland, Private Bag 92019, Auckland 1142, New Zealand
    Mol Cell Neurosci 47:53-60. 2011
    ..We therefore examined the expression of Mash1, Dlx2, Pax6 and Olig2 in SVZ-derived neural precursor cell populations across a range of times following quinolinic acid (QA) ..
  58. pmc Evaluation of Pax6 mutant rat as a model for autism
    Toshiko Umeda
    Division of Developmental Neuroscience, Tohoku University Graduate School of Medicine, Sendai, Japan
    PLoS ONE 5:e15500. 2010
    Autism is a highly variable brain developmental disorder and has a strong genetic basis. Pax6 is a pivotal player in brain development and maintenance...
  59. ncbi The Optimedin gene is a downstream target of Pax6
    Oleg Grinchuk
    Section of Molecular Mechanisms of Glaucoma, Laboratory of Molecular and Developmental Biology, NEI, National Institutes of Health, Bethesda, Maryland 20892 0704, USA
    J Biol Chem 280:35228-37. 2005
    ..The expression pattern of the Optimedin A variant in the eye and brain overlaps with that for Pax6, which encodes a protein containing the paired and homeobox DNA-binding domains...
  60. doi The activation of the rat insulin gene II by BETA2 and PDX-1 in rat insulinoma cells is repressed by Pax6
    Gabriele Wolf
    Department of Medical Biochemistry and Molecular Biology, University of Greifswald, Klinikum, Greifswald, Germany
    Mol Endocrinol 24:2331-42. 2010
    The transcriptional transactivator Pax6 binds the pancreatic islet cell-specific enhancer sequence (PISCES) of the rat insulin I gene. However the human, mouse, and rat insulin gene II promoters do not contain a PISCES element...
  61. pmc Expression of pax6 and sox2 in adult olfactory epithelium
    Zhen Guo
    Cell, Molecular, and Developmental Biology Graduate Program, Sackler School of Graduate Biomedical Sciences, Tufts University, Boston, MA 02111, USA
    J Comp Neurol 518:4395-418. 2010
    ..However, the identity of the stem cells--and their regulation--remain poorly defined. The transcription factors Pax6 and Sox2 are characteristic of stem cells in many tissues, including the brain...
  62. ncbi Adult pancreatic islets require differential pax6 gene dosage
    Akihiro Hamasaki
    Department of Diabetes and Clinical Nutrition, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Biochem Biophys Res Commun 353:40-6. 2007
    b>Pax6, a paired homeodomain transcription factor, plays crucial roles in morphogenesis of eye, central nervous system, and pancreatic islets...
  63. pmc Pax6 controls the expression of critical genes involved in pancreatic {alpha} cell differentiation and function
    Yvan Gosmain
    Diabetes Unit, Division of Endocrinology, Diabetes and Nutrition, University Hospital, University Medical Center, University of Geneva, 1211 Geneva 4, Switzerland
    J Biol Chem 285:33381-93. 2010
    The paired box homeodomain Pax6 is crucial for endocrine cell development and function and plays an essential role in glucose homeostasis. Indeed, mutations of Pax6 are associated with diabetic phenotype...
  64. ncbi Pax6-dependent boundary defines alignment of migrating olfactory cortex neurons via the repulsive activity of ephrin A5
    Tadashi Nomura
    Division of Developmental Neuroscience, Center for Translational and Advanced Animal Research CTTAR, Seiryo machi, 980 8575, Japan
    Development 133:1335-45. 2006
    ..Here, we report Pax6-dependent alignment of the olfactory cortex neurons in the developing telencephalon...
  65. pmc Downstream genes of Pax6 revealed by comprehensive transcriptome profiling in the developing rat hindbrain
    Keiko Numayama-Tsuruta
    Division of Developmental Neuroscience, Center for Translational and Advanced Animal Research, Tohoku University Graduate School of Medicine, 2 1 Seiryo machi, Aoba ku, Sendai 980 8575, Japan
    BMC Dev Biol 10:6. 2010
    The transcription factor Pax6 is essential for the development of the central nervous system and it exerts its multiple functions by regulating the expression of downstream target molecules...