p54

Summary

Gene Symbol: p54
Description: nucleobindin 2
Alias: Nefa, p54, nucleobindin-2, DNA-binding protein NEFA, nesfatin-1, prepronefastin, prepronesfatin
Species: rat

Top Publications

  1. ncbi Identification of nesfatin-1 as a satiety molecule in the hypothalamus
    Shinsuke Oh-I
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Showa machi, Maebashi 371 8511, Japan
    Nature 443:709-12. 2006
  2. pmc Stressor-responsive central nesfatin-1 activates corticotropin-releasing hormone, noradrenaline and serotonin neurons and evokes hypothalamic-pituitary-adrenal axis
    Natsu Yoshida
    Division of Integrative Physiology, Department of Physiology, Jichi Medical University School of Medicine, Shimotsuke, Tochigi 329 0498, Japan
    Aging (Albany NY) 2:775-84. 2010
  3. doi Nucleobindin-2/nesfatin in the endocrine pancreas: distribution and relationship to glycaemic state
    Kylie S Foo
    Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
    J Endocrinol 204:255-63. 2010
  4. doi Nesfatin-1-regulated oxytocinergic signaling in the paraventricular nucleus causes anorexia through a leptin-independent melanocortin pathway
    Yuko Maejima
    Division of Integrative Physiology, Department of Physiology, Jichi Medical University School of Medicine, Shimotsuke, Tochigi 329 0498, Japan
    Cell Metab 10:355-65. 2009
  5. pmc Central nesfatin-1 reduces dark-phase food intake and gastric emptying in rats: differential role of corticotropin-releasing factor2 receptor
    Andreas Stengel
    Center for Neurovisceral Sciences and Women s Health CURE, Building 115, Room 117, Veterans Administration Greater Los Angeles Healthcare System, 11301 Wilshire Boulevard, Los Angeles, California 90073, USA
    Endocrinology 150:4911-9. 2009
  6. doi CCK-8S activates c-Fos in a dose-dependent manner in nesfatin-1 immunoreactive neurons in the paraventricular nucleus of the hypothalamus and in the nucleus of the solitary tract of the brainstem
    Steffen Noetzel
    Department of Medicine, Division Hepatology, Gastroenterology, and Endocrinology Charité, Campus Virchow Universitätsmedizin Berlin, Germany
    Regul Pept 157:84-91. 2009
  7. ncbi Nesfatin-1: an overview and future clinical application
    Hiroyuki Shimizu
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Maebashi, Japan
    Endocr J 56:537-43. 2009
  8. ncbi The calcium-binding protein p54/NEFA is a novel luminal resident of medial Golgi cisternae that traffics independently of mannosidase II
    Valérie M Morel-Huaux
    Cell Biology Unit, Christian de Duve Institute of Cellular Pathology and Universite catholique de Louvain, Brussels, Belgium
    Eur J Cell Biol 81:87-100. 2002
  9. pmc Nesfatin-1 immunoreactivity in rat brain and spinal cord autonomic nuclei
    Miriam Goebel
    CURE Digestive Diseases Research Center, Digestive Diseases Division, Department of Medicine, David Geffen School of Medicine, UCLA, Los Angeles, CA 90073, USA
    Neurosci Lett 452:241-6. 2009
  10. doi Pancreatic beta cells colocalize insulin and pronesfatin immunoreactivity in rodents
    Ronald Gonzalez
    Department of Biology, York University, Toronto, Ont, Canada
    Biochem Biophys Res Commun 381:643-8. 2009

Scientific Experts

  • Gina L C Yosten
  • Luo Xu
  • Guangyao Song
  • Hideyuki Yamawaki
  • H Shimizu
  • Marion S Bonnet
  • M Tanida
  • Andreas Stengel
  • Masatomo Mori
  • Miriam Goebel
  • YVETTE TACHE
  • Yuko Maejima
  • Yuko Tagaya
  • Toshihiko Yada
  • Masanori Nakata
  • Peter Kobelt
  • Natsu Yoshida
  • Lixin Wang
  • Carlos Dieguez
  • Aya Osaki
  • Burghard F Klapp
  • Katalin Könczöl
  • Shuichi Okada
  • Tobias Inhoff
  • Nils W G Lambrecht
  • Hubert Monnikes
  • Tatsushi Onaka
  • Udval Sedbazar
  • Katsuya Dezaki
  • Daisuke Kohno
  • Philip Prinz
  • Takeshi Iwasa
  • Xun Cao
  • Agnieszka Dettlaff-Pokora
  • Shinsuke Oh-I
  • Lucía L Senín
  • Ya yun Xu
  • Zi Bin Tian
  • Mitsuhiro Yoshimura
  • Ya Ying Cheng
  • Kenichi Katsurada
  • Maria F Garcés
  • Miriam Goebel-Stengel
  • A Stengel
  • A Szlachcic
  • T Angelone
  • Szilvia Vas
  • Fang Yuan Jia
  • Kihachi Ohshima
  • Sonia Jego
  • D García-Galiano
  • Yusaku Iwasaki
  • Atsuko Miura
  • Mengliu Yang
  • Xue Liang Li
  • Miklos Palkovits
  • Shigetomo Suyama
  • Lin Lin
  • Zsuzsanna E Toth
  • Mikel Garcia-Marcos
  • Matteo Riva
  • Zheng Liu
  • R Gonzalez
  • David García-Galiano
  • Kylie S Foo
  • D N Roy
  • Ai qing Zhang
  • Bertram Wiedenmann
  • Eisuke Takano
  • Norbert Bannert
  • Steffen Noetzel
  • Tetsurou Satoh
  • Ronald Gonzalez
  • Masanobu Yamada
  • Julie Brodeur
  • Koushi Hashimoto
  • G Cristina Brailoiu
  • Minoru Irahara
  • Akira Kuwahara
  • Xiao Min Liu
  • Tomasz Sledzinski
  • Xiao Zhou
  • Munkhsaikhan Munkhzaya
  • Mayila Yiliyasi
  • Toshiya Matsuzaki
  • Yang Cao
  • Julian Swierczynski
  • Matthias Rose
  • Altankhuu Tungalagsuvd
  • Li Hong Zhou

Detail Information

Publications59

  1. ncbi Identification of nesfatin-1 as a satiety molecule in the hypothalamus
    Shinsuke Oh-I
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Showa machi, Maebashi 371 8511, Japan
    Nature 443:709-12. 2006
    ..Here we show that nesfatin, corresponding to NEFA/nucleobindin2 (NUCB2), a secreted protein of unknown function, is expressed in the appetite-control hypothalamic ..
  2. pmc Stressor-responsive central nesfatin-1 activates corticotropin-releasing hormone, noradrenaline and serotonin neurons and evokes hypothalamic-pituitary-adrenal axis
    Natsu Yoshida
    Division of Integrative Physiology, Department of Physiology, Jichi Medical University School of Medicine, Shimotsuke, Tochigi 329 0498, Japan
    Aging (Albany NY) 2:775-84. 2010
    ..These results indicate that the central nesfatin-1 system is stimulated by stress and activates CRH, NA and 5-HT neurons and hypothalamic-pituitary-adrenal axis, evoking both central and peripheral stress responses...
  3. doi Nucleobindin-2/nesfatin in the endocrine pancreas: distribution and relationship to glycaemic state
    Kylie S Foo
    Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
    J Endocrinol 204:255-63. 2010
    ..However, our findings, together with previous reports, appear more compatible with intracellular actions rather than with endocrine/paracrine communication, and suggest that NUCB2 in serum derives primarily from non-islet sources...
  4. doi Nesfatin-1-regulated oxytocinergic signaling in the paraventricular nucleus causes anorexia through a leptin-independent melanocortin pathway
    Yuko Maejima
    Division of Integrative Physiology, Department of Physiology, Jichi Medical University School of Medicine, Shimotsuke, Tochigi 329 0498, Japan
    Cell Metab 10:355-65. 2009
    ..The present results reveal the nesfatin-1-operative oxytocinergic signaling in the PVN that triggers leptin-independent melanocortin-mediated anorexia...
  5. pmc Central nesfatin-1 reduces dark-phase food intake and gastric emptying in rats: differential role of corticotropin-releasing factor2 receptor
    Andreas Stengel
    Center for Neurovisceral Sciences and Women s Health CURE, Building 115, Room 117, Veterans Administration Greater Los Angeles Healthcare System, 11301 Wilshire Boulevard, Los Angeles, California 90073, USA
    Endocrinology 150:4911-9. 2009
    ..Activation of nesfatin-1 neurons by cholecystokinin at sites regulating food intake may suggest a role in gut peptide satiation effect...
  6. doi CCK-8S activates c-Fos in a dose-dependent manner in nesfatin-1 immunoreactive neurons in the paraventricular nucleus of the hypothalamus and in the nucleus of the solitary tract of the brainstem
    Steffen Noetzel
    Department of Medicine, Division Hepatology, Gastroenterology, and Endocrinology Charité, Campus Virchow Universitätsmedizin Berlin, Germany
    Regul Pept 157:84-91. 2009
    ..No effect on the number of c-Fos-ir neurons was observed in the ARC. These results suggest that the effects of CCK on the HPA axis and on food intake may, at least in part, be mediated by nesfatin-1-ir neurons in the PVN...
  7. ncbi Nesfatin-1: an overview and future clinical application
    Hiroyuki Shimizu
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Maebashi, Japan
    Endocr J 56:537-43. 2009
    Nesfatin/nucleobindin 2 (NUCB2) is expressed in the appetite-control hypothalamic nuclei and brainstem nuclei. Nesfatin/NUCB2 expression in the paraventricular nucleus of the hypothalamus was modulated by starvation and refeeding...
  8. ncbi The calcium-binding protein p54/NEFA is a novel luminal resident of medial Golgi cisternae that traffics independently of mannosidase II
    Valérie M Morel-Huaux
    Cell Biology Unit, Christian de Duve Institute of Cellular Pathology and Universite catholique de Louvain, Brussels, Belgium
    Eur J Cell Biol 81:87-100. 2002
    ..and identified by matrix-assisted laser desorption ionization/time-of-flight (MALDI-TOF) mass spectrometry as NEFA, a calcium-binding protein (Barnikol-Watanabe et al., 1994, Biol. Chem. Hoppe Seyler, 375, 497-512)...
  9. pmc Nesfatin-1 immunoreactivity in rat brain and spinal cord autonomic nuclei
    Miriam Goebel
    CURE Digestive Diseases Research Center, Digestive Diseases Division, Department of Medicine, David Geffen School of Medicine, UCLA, Los Angeles, CA 90073, USA
    Neurosci Lett 452:241-6. 2009
    ..The features and distributions of nesfatin-1 IR and mRNA expression in the brain and spinal cord suggest that NUCB2/nesfatin-1 could play a wider role in autonomic regulation of visceral-endocrine functions besides food intake...
  10. doi Pancreatic beta cells colocalize insulin and pronesfatin immunoreactivity in rodents
    Ronald Gonzalez
    Department of Biology, York University, Toronto, Ont, Canada
    Biochem Biophys Res Commun 381:643-8. 2009
    Nesfatin-1 is a recently discovered feeding inhibitory peptide encoded in the precursor protein, nucleobindin 2 (pronesfatin). Previous studies have shown pronesfatin expression in the brain, stomach and pancreas...
  11. ncbi Nesfatin-1 neurons in paraventricular and supraoptic nuclei of the rat hypothalamus coexpress oxytocin and vasopressin and are activated by refeeding
    Daisuke Kohno
    Division of Integrative Physiology, Department of Physiology, Jichi Medical University, School of Medicine, Tochigi 329 0498, Japan
    Endocrinology 149:1295-301. 2008
    ..Feeding-activated nesfatin-1 neurons in the PVN and SON could play a role in the postprandial regulation of feeding behavior and energy homeostasis...
  12. ncbi Nesfatin-1: distribution and interaction with a G protein-coupled receptor in the rat brain
    G Cristina Brailoiu
    Department of Pharmacology, Temple University School of Medicine, 3420 North Broad Street, Philadelphia, PA 19140, USA
    Endocrinology 148:5088-94. 2007
    ....
  13. pmc Nesfatin-1 exerts cardiovascular actions in brain: possible interaction with the central melanocortin system
    Gina L C Yosten
    Saint Louis Univ, Dept of Pharmacological and Physiological Science, 1402 S Grand Blvd, St Louis, MO 63104, USA
    Am J Physiol Regul Integr Comp Physiol 297:R330-6. 2009
    ..Thus we have identified a novel action of nesfatin-1, in addition to its anorexigenic effects, to stimulate autonomic nervous system activity...
  14. pmc Restraint stress activates nesfatin-1-immunoreactive brain nuclei in rats
    Miriam Goebel
    CURE Digestive Diseases Research Center, Center for Neurobiology of Stress, Digestive Diseases Division, Department of Medicine, David Geffen School of Medicine, UCLA, Los Angeles, California, USA
    Brain Res 1300:114-24. 2009
    ..These data demonstrate that nesfatin-1 neurons are part of the hypothalamic and hindbrain neuronal cell groups activated by restraint suggesting a possible role of nesfatin-1 in the response to stress...
  15. doi Nesfatin-1/NUCB2 may participate in the activation of the hypothalamic-pituitary-adrenal axis in rats
    Katalin Könczöl
    Neuromorphological and Neuroendocrine Research Laboratory, Semmelweis University, Hungarian Academy of Sciences, Budapest, Hungary
    Neurochem Int 57:189-97. 2010
    ..These data provide the first evidence for possible participation of nesfatin-1/NUCB2 in the stress-axis regulation, both at the level of the brainstem and in the hypothalamus...
  16. doi Endogenous GLP-1 acts on paraventricular nucleus to suppress feeding: projection from nucleus tractus solitarius and activation of corticotropin-releasing hormone, nesfatin-1 and oxytocin neurons
    Kenichi Katsurada
    Division of Integrative Physiology, Department of Physiology, Jichi Medical University School of Medicine, 3311 1 Shimotsuke, Tochigi 329 0498, Japan Division of Cardiovascular Medicine, Department of Internal Medicine, Jichi Medical University School of Medicine, 3311 1 Shimotsuke, Tochigi 329 0498, Japan
    Biochem Biophys Res Commun 451:276-81. 2014
    ..This study reveals a neuronal basis for the anorexigenic effect of endogenous GLP-1 in the brain. ..
  17. pmc Role of nesfatin-1 in a rat model of visceral hypersensitivity
    Fang Yuan Jia
    Department of Gastroenterology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, Jiangsu Province, China
    World J Gastroenterol 19:3487-93. 2013
    ..To explore the role of nesfatin-1 on irritable bowel syndrome (IBS)-like visceral hypersensitivity...
  18. pmc Expression of gastrointestinal nesfatin-1 and gastric emptying in ventromedial hypothalamic nucleus- and ventrolateral hypothalamic nucleus-lesioned rats
    Zi Bin Tian
    Zi Bin Tian, Run Jun Deng, Liang Zhou Wei, Xin Juan Kong, Xue Li Ding, Xue Jing, Cui Ping Zhang, Department of Gastroenterology, Affiliated Hospital of Medical College of Qingdao University, Qingdao 266003, Shandong Province, China
    World J Gastroenterol 20:6897-905. 2014
    ....
  19. doi Regulation of NucB2/Nesfatin-1 throughout rat pregnancy
    Maria F Garcés
    Department of Physiology, School of Medicine, Universidad Nacional de Colombia, Bogota, Colombia
    Physiol Behav 133:216-22. 2014
    ..by post-translational cleavage from the N-terminus region DNA binding/EF-hand/acidic amino acid rich region (NEFA)/nucleobindin2 (NucB2) protein through proteolytic prohormone convertases...
  20. doi A role of nesfatin-1/NucB2 in dehydration-induced anorexia
    Mitsuhiro Yoshimura
    Department of Physiology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan
    Am J Physiol Regul Integr Comp Physiol 307:R225-36. 2014
    ..These results suggested that nesfatin-1/NucB2 is a crucial peptide in dehydration-induced anorexia. ..
  21. pmc Neural circuitry underlying the central hypertensive action of nesfatin-1: melanocortins, corticotropin-releasing hormone, and oxytocin
    Gina L C Yosten
    Department of Pharmacological and Physiological Science, Saint Louis University School of Medicine, Saint Louis, Missouri
    Am J Physiol Regul Integr Comp Physiol 306:R722-7. 2014
    ....
  22. ncbi Experimental healing of preexisting gastric ulcers induced by hormones controlling food intake ghrelin, orexin-A and nesfatin-1 is impaired under diabetic conditions. A key to understanding the diabetic gastropathy?
    A Szlachcic
    Department of Physiology Jagiellonian University Medical College, Cracow, Poland
    J Physiol Pharmacol 64:625-37. 2013
    ....
  23. doi Gastric distension activates NUCB2/nesfatin-1-expressing neurons in the nucleus of the solitary tract
    Marion S Bonnet
    Physiology and Physiopathology of Motor and Autonomic Nervous Systems PPSN, EA4667, University of Aix Marseille, Marseille, France
    Regul Pept 187:17-23. 2013
    ..Nesfatin-1 was recently identified as a neuropeptide cleaved from the N-terminal part of NEFA/nucleobindin 2 precursor (NUCB2)...
  24. doi Role of NUCB2/Nesfatin-1 in the hypothalamic control of energy homeostasis
    A Stengel
    Charité Center for Internal Medicine and Dermatology, Division for General Internal and Psychosomatic Medicine, Charite Universitatsmedizin Berlin, Berlin, Germany
    Horm Metab Res 45:975-9. 2013
    ..The present review describes the current state-of-knowledge on central nesfatin-1's effects on food intake and body weight and highlights important missing links regarding cellular signaling mechanisms involved in nesfatin-1's action. ..
  25. ncbi [Expression of nesfatin-1/NUCB2 and ghrelin in gastric mucosa of rats with intrauterine growth retardation]
    Ya Ying Cheng
    Department of Pediatrics, Hebei General Hospital, Shijiazhuang 050051, China
    Zhongguo Dang Dai Er Ke Za Zhi 16:1051-6. 2014
    ..To investigate the expression of nesfatin-1/NUCB2 and ghrelin in the gastric mucosa of rats with intrauterine growth retardation (IUGR) and its significance...
  26. pmc Upregulation of Pnpla2 and Abhd5 and downregulation of G0s2 gene expression in mesenteric white adipose tissue as a potential reason for elevated concentration of circulating NEFA after removal of retroperitoneal, epididymal, and inguinal adipose tissue
    Agnieszka Dettlaff-Pokora
    Department of Biochemistry, Medical University of Gdansk, Debinki 1, 80 211, Gdansk, Poland
    Mol Cell Biochem 422:21-29. 2016
    Elevated concentrations of circulating non-esterified fatty acids (NEFA) were reported in (a) humans with lipodystrophy, (b) humans following bariatric surgery, and (c) transgenic mice with reduced amounts of adipose tissue...
  27. doi Regulation of NUCB2/nesfatin-1 production in rat's stomach and adipose tissue is dependent on age, testosterone levels and lactating status
    Lucía L Senín
    Grupo Fisiopatologia Endocrina, Complexo Hospitalario Universitario de Santiago CHUS SERGAS CIBER Fisiopatología Obesidad y Nutrición, Instituto de Salud Carlos III, Spain Instituto de Investigación Sanitaria de Santiago de Compostela IDIS, Santiago de Compostela, Spain
    Mol Cell Endocrinol 411:105-12. 2015
    Nesfatin-1, which is derived from the NEFA/nucleobindin 2 (NUCB2) precursor, was recently identified as an anorexigenic peptide that is produced in several tissues including the hypothalamus...
  28. doi Nesfatin-1 signaling in the basom edial amygdala modulates the gastric distension-sensitive neurons discharge and decreases gastric motility via melanocortin 3/4 receptors and modified by the arcuate nucleus
    Luo Xu
    Department of Pathophysiology, Medical College of Qingdao University, Qingdao, Shandong, PR China Electronic address
    Eur J Pharmacol 764:164-72. 2015
    ..It is suggested that nesfatin-1 in the BMA plays an important role in decreasing gastric motility and the Arc may be involved in this regulation process. ..
  29. doi Acute, but not chronic, stress increased the plasma concentration and hypothalamic mRNA expression of NUCB2/nesfatin-1 in rats
    Ya yun Xu
    School of Pharmacy, Anhui Medical University, Hefei, 230032 Anhui, China
    Neuropeptides 54:47-53. 2015
    ..These results indicated that acute stress, but not chronic stress, increased the plasma concentration and hypothalamic mRNA expression of NUCB2/nesfatin-1 in rats. ..
  30. doi Expression of NUCB2/nesfatin-1 in the taste buds of rats
    Xun Cao
    Department of Endocrinology, Harbin Medical University, Harbin 150001, Heilongjiang Province, China
    Endocr J 63:37-45. 2016
    Nesfatin-1, an anorexigenic peptide derived from nucleobindin 2 (NUCB2), is closely involved in feeding behavior, glycometabolism, and satiety regulation...
  31. doi Developmental changes in the hypothalamic mRNA levels of nucleobindin-2 (NUCB2) and their sensitivity to fasting in male and female rats
    Takeshi Iwasa
    Department of Obstetrics and Gynecology, Institute of Biomedical Sciences, Tokushima University Graduate School, 3 18 15 Kuramoto cho, Tokushima 770 8503, Japan Electronic address
    Int J Dev Neurosci 49:46-9. 2016
    ..However, hypothalamic NUCB2 mRNA expression does not become sensitive to a negative energy balance during the neonatal to pre-pubertal period. ..
  32. doi Peripheral and central localization of the nesfatin-1 receptor using autoradiography in rats
    Philip Prinz
    Charité Center for Internal Medicine and Dermatology, Department for Psychosomatic Medicine, Charite Universitatsmedizin Berlin, Hindenburgdamm 30, 12203 Berlin, Germany
    Biochem Biophys Res Commun 470:521-7. 2016
    ..Based on the distribution of nesfatin-1 autoradiography, nesfatin-1 is a pleiotropic hormone that is involved in the regulation of several homeostatic functions. ..
  33. doi Enhanced expression of nesfatin/nucleobindin-2 in white adipose tissue of ventromedial hypothalamus-lesioned rats
    Aya Osaki
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Maebashi, Japan
    Neurosci Lett 521:46-51. 2012
    ..Further, this action may be mediated via inhibition of the sympathetic nerve activity...
  34. pmc Secreted nucleobindin-2 inhibits 3T3-L1 adipocyte differentiation
    Yuko Tagaya
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, 3 39 15 Showa Machi, Maebashi, Gunma 371 8511, Japan
    Protein Pept Lett 19:997-1004. 2012
    ..Taken together, these data indicate that secreted Nucleobindin-2 is a suppressor of adipocyte differentiation through inhibition of cAMP production and insulin signal...
  35. doi Nesfatin-1 stimulates glucagon and insulin secretion and beta cell NUCB2 is reduced in human type 2 diabetic subjects
    Matteo Riva
    Department of Clinical Sciences, Lund University Diabetes Centre, Malmo, Sweden
    Cell Tissue Res 346:393-405. 2011
    Nesfatin-1 is a novel anorexigenic regulatory peptide. The peptide is the N-terminal part of nucleobindin 2 (NUCB2) and is expressed in brain areas regulating feeding...
  36. pmc Nesfatin-1 action in the brain increases insulin sensitivity through Akt/AMPK/TORC2 pathway in diet-induced insulin resistance
    Mengliu Yang
    Department of Endocrinology, Second Affiliated Hospital, Chongqing Medical University, Chongqing, China
    Diabetes 61:1959-68. 2012
    Nesfatin-1, derived from nucleobindin 2, was recently identified as an anorexigenic signal peptide. However, its neural role in glucose homeostasis and insulin sensitivity is unknown...
  37. doi Sex-specific effects of fasting on urocortin 1, cocaine- and amphetamine-regulated transcript peptide and nesfatin-1 expression in the rat Edinger-Westphal nucleus
    L Xu
    Department of Cellular Animal Physiology, Faculty of Science, EURON, Radboud University Nijmegen, Heyendaalseweg 135, 6525 AJ Nijmegen, The Netherlands
    Neuroscience 162:1141-9. 2009
    ..The peptide level and mRNA of nesfatin-1 were unaffected by fasting. We conclude that npEW-neurons containing Ucn1, CART and nesfatin-1 co-express ObR, and may be involved in leptin-mediated feeding control in male rats only...
  38. pmc Central nesfatin-1-expressing neurons are sensitive to peripheral inflammatory stimulus
    Marion S Bonnet
    Centre de Recherche en Neurobiologie Neurophysiologie de Marseille, UMR 6231 CNRS, Marseille, France
    J Neuroinflammation 6:27. 2009
    ....
  39. doi Nesfatin-1 stimulates renal sympathetic nerve activity in rats
    Mamoru Tanida
    Department of Biomedical Sciences, College of Life Sciences, Ritsumeikan University, Kusatsu, Shiga, Japan
    Neuroreport 22:309-12. 2011
    ..Thus, the stimulating effects of nesfatin-1 administration on the sympathetic nerve activity of the kidney may depend on the central melanocortin system...
  40. pmc G Protein binding sites on Calnuc (nucleobindin 1) and NUCB2 (nucleobindin 2) define a new class of G(alpha)i-regulatory motifs
    Mikel Garcia-Marcos
    Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, California 92093, USA
    J Biol Chem 286:28138-49. 2011
    ..These findings provide the structural basis for the properties of Calnuc and NUCB2 binding to Gα subunits and its regulation by calcium ions...
  41. pmc Lipopolysaccharide increases gastric and circulating NUCB2/nesfatin-1 concentrations in rats
    Andreas Stengel
    CURE Digestive Diseases Research Center, Center for Neurobiology of Stress, Department of Medicine, Digestive Diseases Division, University of California Los Angeles, VA Greater Los Angeles Health Care System, CA 90073, USA
    Peptides 32:1942-7. 2011
    ..These changes are opposite to those of ghrelin in response to LPS supporting a differential gastric regulation of NUCB2/nesfatin-1 and ghrelin expression derived from the same cell by immune challenge...
  42. doi A novel adipocytokine, nesfatin-1 modulates peripheral arterial contractility and blood pressure in rats
    Hideyuki Yamawaki
    Laboratory of Veterinary Pharmacology, School of Veterinary Medicine, Kitasato University, Aomori 034 8628, Japan
    Biochem Biophys Res Commun 418:676-81. 2012
    ..The results are the first to demonstrate that nesfatin-1 modulates blood pressure through directly acting on peripheral arterial resistance...
  43. doi Cellular distribution, regulated expression, and functional role of the anorexigenic peptide, NUCB2/nesfatin-1, in the testis
    D García-Galiano
    Physiology Section, Department of Cell Biology, Physiology, and Immunology, Faculty of Medicine, University of Cordoba, Cordoba, Spain
    Endocrinology 153:1959-71. 2012
    Nesfatin-1, product of the precursor NEFA/nucleobindin2 (NUCB2), was initially identified as anorectic hypothalamic neuropeptide, acting in a leptin-independent manner...
  44. doi Evidence for a role of endogenous nesfatin-1 in the control of water drinking
    G L C Yosten
    Department of Pharmacological and Physiological Science, Saint Louis University School of Medicine, St Louis, MO 63104, USA
    J Neuroendocrinol 24:1078-84. 2012
    ..The results obtained in the present study suggest that locally produced nesfatin-1 may be an important component of the hypothalamic mechanisms controlling fluid and electrolyte homeostasis...
  45. doi Nucleobindin-2 is a positive modulator of EGF-dependent signals leading to enhancement of cell growth and suppression of adipocyte differentiation
    Yuko Tagaya
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, 3 39 15 Showa Machi, Maebashi, Gunma 371 8511, Japan
    Endocrinology 153:3308-19. 2012
    ..Taken together, these data indicate that nucleobindin-2 regulates EGF-stimulated MAPK kinase/Erk signaling, cell proliferation, and adipocyte differentiation...
  46. pmc Nesfatin-1/NUCB2 as a potential new element of sleep regulation in rats
    Szilvia Vas
    Department of Pharmacodynamics, Semmelweis University, Budapest, Hungary
    PLoS ONE 8:e59809. 2013
    ..Since MCH was recognized earlier as a hypnogenic factor, we analyzed the potential role of nesfatin on vigilance...
  47. pmc Tuberal hypothalamic neurons secreting the satiety molecule Nesfatin-1 are critically involved in paradoxical (REM) sleep homeostasis
    Sonia Jego
    Sleep Waking Neuronal Networks, CNRS UMR5292, Lyon, France
    PLoS ONE 7:e52525. 2012
    ..This could be done through the inhibition of downstream targets comprised primarily of the local hypothalamic wake-active orexin- and histamine-containing neurons...
  48. doi Central NUCB2/Nesfatin-1-expressing neurones belong to the hypothalamic-brainstem circuitry activated by hypoglycaemia
    M S Bonnet
    Laboratoire de Physiologie et Physiopathologie du Système Nerveux Somato Moteur et Neurovégétatif, Aix Marseille Universite, Marseille, France
    J Neuroendocrinol 25:1-13. 2013
    ....
  49. doi Nesfatin-1 as a novel cardiac peptide: identification, functional characterization, and protection against ischemia/reperfusion injury
    T Angelone
    Department of Cell Biology, University of Calabria, 87030, Arcavacata di Rende, CS, Italy
    Cell Mol Life Sci 70:495-509. 2013
    ....
  50. doi Nutrient responsive nesfatin-1 regulates energy balance and induces glucose-stimulated insulin secretion in rats
    R Gonzalez
    Laboratory of Integrative Neuroendocrinology, Department of Biology, York University, 4700 Keele Street, Toronto, Ontario, Canada M3J 1P3
    Endocrinology 152:3628-37. 2011
    ..6 mM) and high (16.7 mM), but not at low (2 mM), glucose concentrations. Furthermore, nesfatin-1/nucleobindin 2 release from rat pancreatic islets was stimulated by glucose...
  51. ncbi [Expression of neuropeptides ghrelin and Nesfatin-1 in kainic acid kindling rats]
    Zheng Liu
    Department of Neurosurgery, Affiliated Hospital of Ningxia Medical University, Key Lab of Craniocerbral Diseases, Yinchuan 750004, China
    Zhonghua Yi Xue Za Zhi 91:496-500. 2011
    ..To observed the post-seizure expression level of neuropeptides ghrelin and Nesfatin-1 between the untreated and treated groups in kainic acid-kindling rats and understand the significance of their basic expressions...
  52. pmc 14-Deoxyandrographolide desensitizes hepatocytes to tumour necrosis factor-alpha-induced apoptosis through calcium-dependent tumour necrosis factor receptor superfamily member 1A release via the NO/cGMP pathway
    D N Roy
    Cell Biology and Physiology Division, Indian Institute of Chemical Biology, A Unit of Council of Scientific and Industrial Research, Kolkata, India
    Br J Pharmacol 160:1823-43. 2010
    ....
  53. doi The anorexigenic neuropeptide, nesfatin-1, is indispensable for normal puberty onset in the female rat
    David García-Galiano
    Department of Cell Biology, Physiology and Immunology, University of Cordoba, Cordoba, Spain
    J Neurosci 30:7783-92. 2010
    The hypothalamic peptide, nesfatin-1, derived from the precursor NEFA/nucleobindin 2 (NUCB2), was recently identified as anorexigenic signal, acting in a leptin-independent manner...
  54. pmc Expression of nesfatin-1/NUCB2 in rodent digestive system
    Ai qing Zhang
    Department of Gastroenterology, First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing 210029, Jiangsu Province, China
    World J Gastroenterol 16:1735-41. 2010
    ..To observe the regional distributions and morphological features of nesfatin-1/nucleobindin-2 (NUCB2) immunoreactive (IR) cells in the rodent digestive system...
  55. pmc Novel insight in distribution of nesfatin-1 and phospho-mTOR in the arcuate nucleus of the hypothalamus of rats
    Tobias Inhoff
    Department of Medicine, Division Hepatology, Gastroenterology, and Endocrinology, Charite, Campus Virchow, Universitatsmedizin Berlin, Germany
    Peptides 31:257-62. 2010
    ....
  56. pmc Abdominal surgery activates nesfatin-1 immunoreactive brain nuclei in rats
    Andreas Stengel
    CURE Digestive Diseases Research Center, Center for Neurobiology of Stress, Digestive Diseases Division, Department of Medicine, David Geffen School of Medicine, University of California Los Angeles and Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, CA 90073, USA
    Peptides 31:263-70. 2010
    ....
  57. doi Calnuc binds to LRP9 and affects its endosomal sorting
    Julie Brodeur
    Department of Pharmacology, Faculty of Medicine, Universite de Sherbrooke, QC, Canada
    Traffic 10:1098-114. 2009
    ..This is the first report showing that Calnuc plays a role in receptor trafficking...