Oxt

Summary

Gene Symbol: Oxt
Description: oxytocin/neurophysin 1 prepropeptide
Alias: oxytocin-neurophysin 1, OT-NPI, oxcytocin, oxytocin, prepropeptide, oxytocin/neurophysin (Oxt) gene, complete gene, complete cds
Species: rat

Top Publications

  1. pmc Relationship between gene expression and function of uterotonic systems in the rat during gestation, uterine activation and both term and preterm labour
    Patrice Arthur
    Perinatal Research Centre, Department of Obstetrics and Gynaecology, 220 Heritage Medical Research Centre, University of Alberta, Edmonton, Alberta, Canada T6G 2S2
    J Physiol 586:6063-76. 2008
  2. ncbi Nesfatin-1 neurons in paraventricular and supraoptic nuclei of the rat hypothalamus coexpress oxytocin and vasopressin and are activated by refeeding
    Daisuke Kohno
    Division of Integrative Physiology, Department of Physiology, Jichi Medical University, School of Medicine, Tochigi 329 0498, Japan
    Endocrinology 149:1295-301. 2008
  3. pmc Science review: Vasopressin and the cardiovascular system part 1--receptor physiology
    Cheryl L Holmes
    Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada
    Crit Care 7:427-34. 2003
  4. ncbi Oxytocin release from the rat neurohypophysis into the blood: effects of tachykinin NK-1 and NK-2 receptors agonists and antagonists
    M Juszczak
    Department of Pathophysiology and Experimental Neuroendocrinology, Medical University of Łódź, Poland
    J Physiol Pharmacol 59:553-62. 2008
  5. ncbi CNS region-specific oxytocin receptor expression: importance in regulation of anxiety and sex behavior
    T L Bale
    Neurobiology and Behavior Program, Departments of Pharmacology and Psychiatry, University of Washington, Seattle, Washington 98195, USA
    J Neurosci 21:2546-52. 2001
  6. pmc Centrally released oxytocin mediates mating-induced anxiolysis in male rats
    Martin Waldherr
    Department of Behavioral Neuroendocrinology, University of Regensburg, 93040 Regensburg, Germany
    Proc Natl Acad Sci U S A 104:16681-4. 2007
  7. ncbi Differential kinetics of oxytocin and vasopressin heteronuclear RNA expression in the rat supraoptic nucleus in response to chronic salt loading in vivo
    C Yue
    Laboratory of Neurochemistry, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
    J Neuroendocrinol 20:227-32. 2008
  8. doi Oxytocin receptor activity in the ventrocaudal periaqueductal gray modulates anxiety-related behavior in postpartum rats
    Rayson J Figueira
    Neuroscience Program, 108 Giltner Hall, Michigan State University, East Lansing, MI 48824, USA
    Behav Neurosci 122:618-28. 2008
  9. ncbi The neurohypophyseal hormones vasopressin and oxytocin. Precursor structure, synthesis and regulation
    M Rehbein
    Biol Chem Hoppe Seyler 367:695-704. 1986
  10. ncbi ERK2 mediates oxytocin-stimulated PGE2 synthesis
    Z Strakova
    Department of Obstetrics and Gynecology, University of Texas Medical Branch, Galveston 77555 1062, USA
    Am J Physiol 274:E634-41. 1998

Scientific Experts

Detail Information

Publications130 found, 100 shown here

  1. pmc Relationship between gene expression and function of uterotonic systems in the rat during gestation, uterine activation and both term and preterm labour
    Patrice Arthur
    Perinatal Research Centre, Department of Obstetrics and Gynaecology, 220 Heritage Medical Research Centre, University of Alberta, Edmonton, Alberta, Canada T6G 2S2
    J Physiol 586:6063-76. 2008
    ..This novel combination of functional and genetic expression analyses provides new insight into the physiology of parturition...
  2. ncbi Nesfatin-1 neurons in paraventricular and supraoptic nuclei of the rat hypothalamus coexpress oxytocin and vasopressin and are activated by refeeding
    Daisuke Kohno
    Division of Integrative Physiology, Department of Physiology, Jichi Medical University, School of Medicine, Tochigi 329 0498, Japan
    Endocrinology 149:1295-301. 2008
    ..Feeding-activated nesfatin-1 neurons in the PVN and SON could play a role in the postprandial regulation of feeding behavior and energy homeostasis...
  3. pmc Science review: Vasopressin and the cardiovascular system part 1--receptor physiology
    Cheryl L Holmes
    Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada
    Crit Care 7:427-34. 2003
    ..In part 2 of the review we discuss the effects of vasopressin on vascular smooth muscle and the heart, and we summarize clinical studies of vasopressin in shock states...
  4. ncbi Oxytocin release from the rat neurohypophysis into the blood: effects of tachykinin NK-1 and NK-2 receptors agonists and antagonists
    M Juszczak
    Department of Pathophysiology and Experimental Neuroendocrinology, Medical University of Łódź, Poland
    J Physiol Pharmacol 59:553-62. 2008
    ..The present data strongly indicate a major role for the tachykinin NK-1 receptor in SP- and/or NKA-dependent regulation of OT secretion from the rat neurohypophysis into the blood...
  5. ncbi CNS region-specific oxytocin receptor expression: importance in regulation of anxiety and sex behavior
    T L Bale
    Neurobiology and Behavior Program, Departments of Pharmacology and Psychiatry, University of Washington, Seattle, Washington 98195, USA
    J Neurosci 21:2546-52. 2001
    ..Distinct signal transduction pathways regulating receptor expression and binding in each brain region may mediate in part the ability of oxytocin to exert these differential behavioral effects...
  6. pmc Centrally released oxytocin mediates mating-induced anxiolysis in male rats
    Martin Waldherr
    Department of Behavioral Neuroendocrinology, University of Regensburg, 93040 Regensburg, Germany
    Proc Natl Acad Sci U S A 104:16681-4. 2007
    ..These findings provide direct evidence for an essential role of an activated brain oxytocin system mediating the anxiolytic effect of mating in males...
  7. ncbi Differential kinetics of oxytocin and vasopressin heteronuclear RNA expression in the rat supraoptic nucleus in response to chronic salt loading in vivo
    C Yue
    Laboratory of Neurochemistry, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
    J Neuroendocrinol 20:227-32. 2008
    ....
  8. doi Oxytocin receptor activity in the ventrocaudal periaqueductal gray modulates anxiety-related behavior in postpartum rats
    Rayson J Figueira
    Neuroscience Program, 108 Giltner Hall, Michigan State University, East Lansing, MI 48824, USA
    Behav Neurosci 122:618-28. 2008
    ..Therefore, OT receptor activation in the cPAGv is an important consequence of contact with infants that reduces some anxiety-related behaviors in mother rats...
  9. ncbi The neurohypophyseal hormones vasopressin and oxytocin. Precursor structure, synthesis and regulation
    M Rehbein
    Biol Chem Hoppe Seyler 367:695-704. 1986
    ..This suggests a feedback regulation by the hormone as a possible element in controlling the transcription of the vasopressin gene...
  10. ncbi ERK2 mediates oxytocin-stimulated PGE2 synthesis
    Z Strakova
    Department of Obstetrics and Gynecology, University of Texas Medical Branch, Galveston 77555 1062, USA
    Am J Physiol 274:E634-41. 1998
    ..However, inhibition of OT-induced ERK2 phosphorylation with an ERK kinase inhibitor (PD-98059) markedly reduced OT-stimulated PGE2 synthesis, pointing to the importance of ERK2 activation in OT action...
  11. ncbi Oxytocin links mothering received, mothering bestowed and adult stress responses
    Cort A Pedersen
    Department of Psychiatry CB 7160, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Stress 5:259-67. 2002
    ....
  12. ncbi Pharmacological effects of oxytocin on gastric emptying and intestinal transit of a non-nutritive liquid meal in female rats
    Chiu Lung Wu
    Department of Physiology, School of Medicine, National Yang Ming University, Shih Pai, Taipei 11221, Taiwan, Republic of China
    Naunyn Schmiedebergs Arch Pharmacol 367:406-13. 2003
    ..These results suggest that OT inhibits gastric emptying and gastrointestinal transit in female rats via a mechanism involving CCK stimulation and CCK(1) receptor activation...
  13. ncbi Central blockade of oxytocin receptors during late gestation disrupts systemic release of oxytocin during suckling in rats
    D L Lipschitz
    Department of Pharmacology and Toxicology, College of Pharmacy, University of Utah, Salt Lake City, UT 84112, USA
    J Neuroendocrinol 15:743-8. 2003
    ..These data suggest that central actions of oxytocin during late gestation are necessary for the normal timing of systemic release of oxytocin during suckling, normal pup weight gain, and maintenance of maternal body weight...
  14. pmc Oxytocin in cardiac ontogeny
    Marek Jankowski
    Centre de Recherche, Centre Hospitalier de l Universite de Montreal, Hotel Dieu, 3840 rue Saint Urbain, Montreal, QC, Canada H2W 1T8
    Proc Natl Acad Sci U S A 101:13074-9. 2004
    ..The results support the hypothesis that RA induces cardiomyogenesis by activation of the cardiac OT system...
  15. ncbi Oxytocin and estrogen promote rapid formation of functional GABA synapses in the adult supraoptic nucleus
    Dionysia T Theodosis
    INSERM, U 378, Bordeaux F33077 France University Victor Segalen, Bordeaux F33077, France
    Mol Cell Neurosci 31:785-94. 2006
    ..Our observations thus offer direct evidence that hypothalamic GABAergic microcircuitries can undergo rapid and functional remodeling under changing neuroendocrine conditions...
  16. doi Vaginocervical stimulation enhances social recognition memory in rats via oxytocin release in the olfactory bulb
    A Larrazolo-López
    Departamento de Fisiologia, Facultad de Medicina, Universidad Nacional Autonoma de Mexico, Delegacion Coyoacan, 04510 Ciudad Universitaria, D F, Mexico
    Neuroscience 152:585-93. 2008
    ..The vagus and pelvic nerves are responsible for carrying the information from the pelvic area to the CNS...
  17. doi The effects of alprostadil on hypothalamic and amygdalar function and the central expression of oxytocin: a potential central role of alprostadil cream
    Xiangrong Sun
    Department of Pathophysiology, Medical College of Qingdao University, Qingdao, China
    J Sex Med 6:81-90. 2009
    ..However, few researchers have investigated the mechanism of the alprostadil cream on the central nervous system (CNS)...
  18. doi Centrally administered adrenomedullin 5 activates oxytocin-secreting neurons in the hypothalamus and elevates plasma oxytocin level in rats
    Hiroki Otsubo
    Department of Physiology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan
    J Endocrinol 202:237-47. 2009
    ..Dual immunostaining for Fos/oxytocin (OXT) and Fos/arginine vasopressin (AVP) revealed that OXT-LI neurones predominantly colocalized Fos-LI compared with ..
  19. doi Expressions of per1 clock gene and genes of signaling peptides vasopressin, vasoactive intestinal peptide, and oxytocin in the suprachiasmatic and paraventricular nuclei of hypertensive TGR[mREN2]27 rats
    Zuzana Dzirbíková
    Department of Animal Physiology and Ethology, Faculty of Natural Sciences, Comenius University Bratislava, Slovak Republic
    Cell Mol Neurobiol 31:225-32. 2011
    ..of genes encoding vasopressin (AVP), vasoactive intestinal peptide (VIP) in the SCN, and AVP and oxytocin (OXT) in the PVN were studied by in situ hybridization...
  20. doi Oxytocin in the periaqueductal grey regulates nociception in the rat
    Jun Yang
    School of Pharmacy, Xinxiang Medical University, Xixiang, Henan 453003, China
    Regul Pept 169:39-42. 2011
    Studies have demonstrated that oxytocin (OXT) plays important roles in pain modulation in the central nervous system, and there are OXT receptors in the periaqueductal grey (PAG)...
  21. pmc Oxytocin and vasopressin involved in restraint water-immersion stress mediated by oxytocin receptor and vasopressin 1b receptor in rat brain
    Dong Qin Zhao
    Key Laboratory of Animal Resistance of Shandong Province, College of Life Sciences, Shandong Normal University, Shandong Province, People s Republic of China
    PLoS ONE 6:e23362. 2011
    ..The present study was to study the role of vasopressinergic and oxytocinergic neurons during the restraint water-immersion stress...
  22. pmc Yes, I am ready now: differential effects of paced versus unpaced mating on anxiety and central oxytocin release in female rats
    Kewir D Nyuyki
    Department of Behavioral and Molecular Neurobiology, University of Regensburg, Regensburg, Bavaria, Germany
    PLoS ONE 6:e23599. 2011
    ..These findings reveal that the positive consequences of mating in females are dependent on her ability to control sexual interactions, and that brain OT release is at least in part the underlying neurobiological correlate...
  23. doi Vasopressin, oxytocin, and social odor recognition
    Douglas W Wacker
    Centre for Integrative Physiology, University of Edinburgh, Edinburgh EH8 9XD, UK
    Horm Behav 61:259-65. 2012
    ..This article is part of a Special Issue entitled Oxytocin, Vasopressin, and Social Behavior...
  24. doi Affiliative behavior attenuates stress responses of GI tract via up-regulating hypothalamic oxytocin expression
    Reji Babygirija
    Department of Surgery, Medical College of Wisconsin, Milwaukee, WI, United States
    Auton Neurosci 169:28-33. 2012
    Hypothalamic oxytocin (OXT) has stress-attenuating effects. Social interaction in a positive environment continuously activates OXT release system...
  25. pmc Sexual experience increases oxytocin receptor gene expression and protein in the medial preoptic area of the male rat
    Mario Gil
    Department of Psychology and Program in Neuroscience, Florida State University, Tallahassee, FL 32306, USA Electronic address
    Psychoneuroendocrinology 38:1688-97. 2013
    ..Taken together, these data suggest a reciprocal interaction between central OT and behavior, in which OT facilitates copulation and copulation stimulates the OT/OTR system in the brain. ..
  26. doi Presence of oxytocin, vasopressin and atrial natriuretic peptide and their modification in rat hypothalamic paraventricular nucleus during resistance training
    E V Farina
    Dipartimento di Biomedicina Sperimentale e Neuroscienze Cliniche, Sezione di Anatomia Umana, Universita di Palermo, Palermo, Italy
    Anat Histol Embryol 43:159-63. 2014
    ..The functional significance of these changes in OT and VP levels, during and after the protocol, needs to be further investigated...
  27. doi Altered oxytocinergic hypothalamus systems in sepsis
    E Sendemir
    Department of Anatomy, Uludag University, Medical Faculty, Bursa, Turkey
    J Chem Neuroanat 52:44-8. 2013
    ..Systemic oxytocin levels may serve as additional diagnostic marker for sepsis. ..
  28. doi Oxytocin activates calcium signaling in rat sensory neurons through a protein kinase C-dependent mechanism
    Ahmet Ayar
    Department of Physiology, Faculty of Medicine, Karadeniz Technical University, Trabzon, Turkey
    J Physiol Biochem 70:43-8. 2014
    ..The finding of the role of OT in peripheral pain modification may serve as a novel target for the development of new pharmacological strategies for the management of pain...
  29. pmc Oxytocin cells in the supraoptic nucleus receive excitatory synaptic inputs from the contralateral supraoptic and paraventricular nuclei in the lactating rat
    Kazumasa Honda
    Faculty of Nursing and Welfare Sciences, Fukui Prefectural University, Fukui 910 1195, Japan
    J Reprod Dev 59:569-74. 2013
    ..Receipt these synaptic inputs to oxytocin cells may contribute to the synchronized activation of oxytocin cells during the milk ejection reflex. ..
  30. doi The inhibitory effect of anandamide on oxytocin and vasopressin secretion from neurohypophysis is mediated by nitric oxide
    Valeria Luce
    Centro de Estudios Farmacologicos y Botanicos, CEFYBO CONICET UBA, Facultad de Medicina, Paraguay 2155, 1121ABG, Argentina
    Regul Pept 188:31-9. 2014
    ..These findings revealed an interaction between endocannabinoid, nitric oxide and oxytocin/vasopressin systems that could be involved in the modulation of homeostatic, behavioral and reproductive processes. ..
  31. doi Neonatal testosterone suppresses a neuroendocrine pulse generator required for reproduction
    Jean Marc Israel
    1 INSERM, U862, Neurocentre Magendie, F 33077 Bordeaux, France 2 Université de Bordeaux, F 33077 Bordeaux, France
    Nat Commun 5:3285. 2014
    ..This supports the view that stereotypic neuroendocrine pulsatility is governed by CPGs, some of which are subjected to gender-specific perinatal programming. ..
  32. doi Neonatal manipulation of oxytocin prevents lipopolysaccharide-induced decrease in gene expression of growth factors in two developmental stages of the female rat
    Jan Bakos
    Institute of Experimental Endocrinology, Slovak Academy of Sciences, Bratislava, Slovakia Institute of Physiology, Medical Faculty, Comenius University, Bratislava, Slovakia Electronic address
    Neuropeptides 48:281-6. 2014
    ..In conclusion, neonatal manipulation of oxytocin has developmental and sex-dependent effect on markers of brain plasticity. These results also indicate, that oxytocin may be protective against inflammation particularly in females...
  33. pmc The effects of oxytocin on cognitive defect caused by chronic restraint stress applied to adolescent rats and on hippocampal VEGF and BDNF levels
    Ayfer Dayi
    Department of Physiology, School of Medicine, Dokuz Eylul University, Izmir, Turkey
    Med Sci Monit 21:69-75. 2015
    ....
  34. ncbi Evidence that paraventricular nucleus oxytocin neurons link hypothalamic leptin action to caudal brain stem nuclei controlling meal size
    James E Blevins
    VA Puget Sound Health Care System, Research Service 151 1660 S Columbian Wy, Seattle, WA 98108, USA
    Am J Physiol Regul Integr Comp Physiol 287:R87-96. 2004
    ....
  35. ncbi A neuromodulatory role for oxytocin within the supramammillary nucleus
    M R Cumbers
    Department of Anatomy, University of Bristol, School of Medical Sciences, University Walk, Bristol BS8 1TD, UK
    Neuropeptides 41:217-26. 2007
    ..This could have important implications for understanding the diverse neuroendocrine and behavioural functions of central oxytocin, including its role in reward...
  36. ncbi Effect of oxytocin on acupuncture analgesia in the rat
    Jun Yang
    Institute for Pharmaceuticals and Medical Science, Guangdong Bangmin Pharmaceutical Co Ltd, Jianghai Distract, Jiangmen, Guangdong 529080, China
    Neuropeptides 41:285-92. 2007
    ..The data suggested that oxytocin in central nervous system rather than in peripheral organs is involved in acupuncture analgesia...
  37. doi The effect of amiloride during infusion of oxytocin in male sprague-dawley rats: a study of a possible intrarenal target site for oxytocin
    Lina Nordquist
    Department of Medical Cell Biology, Uppsala University, Uppsala, Sweden
    Clin Exp Hypertens 30:151-8. 2008
    ..It is concluded that the intrarenal natriuretic mechanisms of oxytocin do not emanate from the amiloride-sensitive sodium channels...
  38. doi Oxytocin exerts protective effects on in vitro myocardial injury induced by ischemia and reperfusion
    Maria Ondrejcakova
    Institute of Heart Research, Department of Cardiovascular Physiology and Pathophysiology, Slovak Academy of Sciences, Bratislava 84005, Slovakia
    Can J Physiol Pharmacol 87:137-42. 2009
    ..The data suggest that the negative chronotropic action of oxytocin participates in its protective effects on ischemia-reperfusion-induced myocardial injury...
  39. pmc Neuroanatomical evidence for reciprocal regulation of the corticotrophin-releasing factor and oxytocin systems in the hypothalamus and the bed nucleus of the stria terminalis of the rat: Implications for balancing stress and affect
    Joanna Dabrowska
    Center for Translational Social Neuroscience, Yerkes National Primate Research Center, Department of Psychiatry and Behavioral Sciences, Emory University, 954 Gatewood Rd, Atlanta, GA 30329, USA
    Psychoneuroendocrinology 36:1312-26. 2011
    ....
  40. doi Effect of the interaction between food state and the action of estrogen on oxytocinergic system activity
    F Lucio-Oliveira
    Department of Physiology, School of Medicine of Ribeirao Preto, University of Sao Paulo, Avenida Bandeirantes, 3900, 14049 900 Ribeirao Preto SP, Brazil
    J Endocrinol 212:129-38. 2012
    ..These results suggest that E(2) may have an inhibitory effect on OT neurones and may modulate the secretion of OT in response to the increase of osmolality induced by refeeding...
  41. ncbi Intracellular calcium stores regulate activity-dependent neuropeptide release from dendrites
    Mike Ludwig
    Department of Biomedical Sciences, University of Edinburgh Medical School, George Square, Edinburgh EH8 9XD, UK
    Nature 418:85-9. 2002
    ..This priming action makes dendritic oxytocin available for release in response to subsequent spike activity. Priming persists for a prolonged period, changing the nature of interactions between oxytocin neurons and their neighbours...
  42. ncbi Time course of c-fos, vasopressin and oxytocin mRNA expression in the hypothalamus following long-term dehydration
    Lenise Trito Garcia da Silveira
    Departamento de Analises Clinicas, Toxicológicas e Bromatológicas da Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Brasil
    Cell Mol Neurobiol 27:575-84. 2007
    ..Therefore, it is possible that c-fos may be involved in the modulation of VP and OT genes, regulating the mRNA expression levels on a temporally distinct basis within the PVN and SON...
  43. pmc Oxytocin facilitates female sexual maturation through a glia-to-neuron signaling pathway
    Anne Simone Parent
    Developmental Neuroendocrinology Unit, Unioversity of Liège, 4000 Liege, Belgium
    Endocrinology 149:1358-65. 2008
    ..Moreover, astrocytes express oxytocin receptors, whereas GnRH neurons do not. These results suggest that oxytocin facilitates female sexual development and that this effect is mediated by a mechanism involving glial production of PGE(2)...
  44. doi Central vasopressin and oxytocin release: regulation of complex social behaviours
    Alexa H Veenema
    Department of Behavioural Neuroendocrinology, Institute of Zoology, University of Regensburg, Regensburg, Germany
    Prog Brain Res 170:261-76. 2008
    The neuropeptides arginine vasopressin (AVP) and oxytocin (OXT) are acknowledged as important modulators of diverse social behaviours...
  45. pmc Antagonism of oxytocin prevents suckling- and estradiol-induced, but not progesterone-induced, secretion of prolactin
    Jessica E Kennett
    Department of Biological Science, and Program in Neuroscience, Florida State University, Tallahassee, Florida 32306, USA
    Endocrinology 150:2292-9. 2009
    ..These data demonstrate the role of OT in the control of suckling and steroid-induced PRL secretion...
  46. doi Maternal separation interferes with developmental changes in brain vasopressin and oxytocin receptor binding in male rats
    M Lukas
    Department of Behavioral Neuroendocrinology, University of Regensburg, Regensburg, Germany
    Neuropharmacology 58:78-87. 2010
    ....
  47. doi Hypothalamic oxytocin attenuates CRF expression via GABA(A) receptors in rats
    Mehmet Bulbul
    Department of Surgery, Medical College of Wisconsin and Zablocki VA Medical Center, 5000 West National Avenue, Milwaukee, WI 53295, USA
    Brain Res 1387:39-45. 2011
    Centrally released oxytocin (OXT) has anxiolytic and anti-stress effects...
  48. doi Oxytocin in the periaqueductal gray participates in pain modulation in the rat by influencing endogenous opiate peptides
    Jun Yang
    College of Pharmacy, Xinxiang Medical University, Xixiang, Henan 453003, China
    Peptides 32:1255-61. 2011
    ..Our pervious study has demonstrated that intra-PAG injection of oxytocin (OXT) increases the pain threshold, and local administration of OXT receptor antagonist decreases the pain threshold, in ..
  49. doi Both oxytocin and vasopressin are mediators of maternal care and aggression in rodents: from central release to sites of action
    Oliver J Bosch
    Department of Behavioural and Molecular Neurobiology, University of Regensburg, Regensburg, Germany
    Horm Behav 61:293-303. 2012
    ..This article is part of a Special Issue entitled Oxytocin, Vasopressin, and Social Behavior...
  50. doi Central and peripheral release of oxytocin following chronic homotypic stress in rats
    Reji Babygirija
    Department of Surgery, Medical College of Wisconsin, Milwaukee, USA
    Auton Neurosci 167:56-60. 2012
    ..In contrast, there were no significant changes observed in the plasma on day 3 and day 5. This suggests that central, but not peripheral, release of oxytocin plays an important role in response to chronic homotypic stress in rats...
  51. doi Peripheral chemoreceptors mediate training-induced plasticity in paraventricular nucleus pre-autonomic oxytocinergic neurons
    Josiane C Cruz
    Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of S ao Paulo, 05508 000 Sao Paulo, Brazil
    Exp Physiol 98:386-96. 2013
    ....
  52. doi A possible correlation between oxytocin-induced and angiotensin IV-induced anti-hyperalgesia at the spinal level in rats
    Lok Hi Chow
    Department of Pharmacology, National Defense Medical Center, Taipei, Taiwan
    Peptides 39:21-8. 2013
    ..Overall, our study suggests that Ang IV may act through the inhibition of the activity of IRAP to reduce the degradation of oxytocin at the spinal cord, thereby leading to anti-hyperalgesia in rats with inflammation...
  53. pmc The androgen metabolite, 5α-androstane-3β,17β-diol (3β-diol), activates the oxytocin promoter through an estrogen receptor-β pathway
    Ryoko Hiroi
    Department of Basic Medical Sciences, University of Arizona College of Medicine Phoenix, Building ABC1, Room 422, 425 North Fifth Street, Phoenix, Arizona 85004, USA
    Endocrinology 154:1802-12. 2013
    ..Point mutations of the cHRE also prevented OT-luc activation by 3β-diol. These results indicate that 3β-diol induces OT promoter activity via ER-β-cHRE interactions...
  54. doi Beyond the GnRH axis: kisspeptin regulation of the oxytocin system in pregnancy and lactation
    Victoria Scott
    Department of Physiology, University of Otago, Dunedin, New Zealand
    Adv Exp Med Biol 784:201-18. 2013
    ....
  55. ncbi Rat vasopressin and oxytocin genes are linked by a long interspersed repeated DNA element (LINE): sequence and transcriptional analysis of LINE
    E Schmitz
    Institut fur Zellbiochemie und klinische Neurobiologie, UKE, Universitat Hamburg, FRG
    DNA Cell Biol 10:81-91. 1991
    ..The data show that most LINEs are transcribed at their entire length and that a major fraction of respective RNAs does not enter the cytoplasm but remains in the cell nucleus...
  56. ncbi Impact of ether anesthesia on the hypophyseal content of oxytocin neurophysin I and II: a comparative study with ketamine in the rat
    R Zierer
    University of Hawaii, Department of Agric Biochem, Honolulu 96844
    Life Sci 49:1391-7. 1991
    ..Treatment of animals with atropine and diphenylhydantoin in combination with ketamine does not alter the profile of the major hormones from the PP during anesthetic stress...
  57. ncbi Crystal structure analysis of deamino-oxytocin: conformational flexibility and receptor binding
    S P Wood
    Science 232:633-6. 1986
    ..In each of two crystal forms there are two closely related conformers with disulfide bridges of different chirality, which may be important in receptor recognition and activation...
  58. ncbi Expression of the vasopressin and oxytocin genes in rats occurs in mutually exclusive sets of hypothalamic neurons
    E Mohr
    Institut fur Zellbiochemie und klinische Neurobiologie, Universitats Krankenhaus Eppendorf, Hamburg, FRG
    FEBS Lett 242:144-8. 1988
    ..The results demonstrate that upregulation of oxytocin gene transcription is restricted solely to oxytocinergic cells; no oxytocin gene transcripts can be detected in vasopressinergic neurons...
  59. ncbi Oxytocin administered intrathecally preferentially increases heart rate rather than arterial pressure in the rat
    K Yashpal
    Laboratory of Neuroanatomy, Montreal Neurological Institute, Que, Canada
    J Auton Nerv Syst 20:167-78. 1987
    ..Our results are consistent with earlier suggestions that oxytocin may be a chemical mediator of synaptic transmission onto sympathetic preganglionic neurons...
  60. ncbi [Evolution of neurohypophyseal hormones: isolation of active principles from rabbits and rats]
    J Chauvet
    Biochimie 53:1099-104. 1971
  61. ncbi Vasopressin and oxytocin mRNA regulation in the rat assessed by hybridization with synthetic oligonucleotides
    J A Majzoub
    J Biol Chem 258:14061-4. 1983
    ....
  62. ncbi Identification of rat neurophysins: complete amino acid sequences of MSEL- and VLDV-neurophysins
    M T Chauvet
    Biochem Biophys Res Commun 103:595-603. 1981
  63. ncbi The proximal portion of the COOH terminus of the oxytocin receptor is required for coupling to g(q), but not g(i). Independent mechanisms for elevating intracellular calcium concentrations from intracellular stores
    S Hoare
    Department of Obstetrics and Gynecology, University of Texas Medical Branch, Galveston, Texas 77555 1062, USA
    J Biol Chem 274:28682-9. 1999
    ..Furthermore, an increase in intracellular calcium was generated via a G(i)betagamma-tyrosine kinase pathway from intracellular stores that are distinct from G(q)-mediated inositol trisphosphate-regulated stores...
  64. ncbi cAMP stimulation of vasopressin and oxytocin release and regulation of vasopressin mRNA stability: role of auto-facilitation
    Z Song
    Department of Physiology and Biophysics, Chicago Medical School, North Chicago, IL 60064, USA
    J Neuroendocrinol 13:158-65. 2001
    ....
  65. ncbi Intrauterine oxytocin system. Compartmental distribution of oxytocin and oxytocin receptors in rat endometrial epithelium
    G Morel
    CNRS UMR 5578, Universite Claude Bernard Lyon 1, Villeurbanne, France
    Cell Tissue Res 304:377-82. 2001
    ....
  66. ncbi Chromosomal and comparative mapping of rat oxytocin, oxytocin receptor and vasopressin genes
    J Dutil
    Research Centre CHUM, 7 132 Pavillon Jeanne Mance, Hotel Dieu 3850, Rue st urbain, Montreal, Quebec, H2W 1T8, Canada
    Cytogenet Cell Genet 93:57-9. 2001
    ..They are located in chromosome regions previously known to contain quantitative trait loci for blood pressure in various genetic crosses. Thus, they have become valid candidate genes for genetic hypertension...
  67. ncbi Gastric antisecretory and antiulcer activity of oxytocin in rats and guinea pigs
    M Asad
    Department of Pharmacology, Jawaharlal Institute of Post Graduate Medical Education and Research, Pondicherry, India
    Life Sci 70:17-24. 2001
    ..The reversal of oxytocin effect by atosiban, an oxytocin receptor antagonist indicates a role for oxytocin receptors. The antiulcer activity of oxytocin can be attributed to its antisecretory effect...
  68. pmc Neurosteroid regulation of oxytocin and vasopressin release from the rat supraoptic nucleus
    Helene Widmer
    School of Biomedical and Clinical Laboratory Sciences, University of Edinburgh College of Medical and Veterinary Sciences, Edinburgh, UK
    J Physiol 548:233-44. 2003
    ....
  69. ncbi Facilitative role of endogenous oxytocin in noradrenaline release in the rat supraoptic nucleus
    Tatsushi Onaka
    Department of Physiology, Jichi Medical School, Tochigi Ken 329 0498, Japan
    Eur J Neurosci 18:3018-26. 2003
    ..These data suggest that dendritic oxytocin facilitates activation of oxytocin neurons, at least in part by augmentation of noradrenaline release via a presynaptic action...
  70. pmc Rhythmic secretion of prolactin in rats: action of oxytocin coordinated by vasoactive intestinal polypeptide of suprachiasmatic nucleus origin
    Marcel Egli
    Department of Biological Sciecne, Florida State University, Tallahassee, Florida 32306 4340, USA
    Endocrinology 145:3386-94. 2004
    ..This hypothesis is illustrated with a mathematical model...
  71. ncbi Regulation of 5alpha-reductase isoforms by oxytocin in the rat ventral prostate
    S J Assinder
    Department of Anatomy and Structural Biology, School of Medical Sciences, University of Otago, Dunedin, New Zealand
    Endocrinology 145:5767-73. 2004
    ..In conclusion, OT is involved in regulating conversion of testosterone to the biologically active dihydrotestosterone in the rat ventral prostate. It does so by differential regulation of 5alpha-reductase isoforms I and II...
  72. ncbi Evidence for an interaction between CB1 cannabinoid and oxytocin receptors in food and water intake
    A N A Verty
    School of Psychology, University of New England, Armidale, NSW 2351, Australia
    Neuropharmacology 47:593-603. 2004
    ....
  73. ncbi Co-expression of vasopressin and androgen-binding protein in the rat hypothalamus
    Gustav F Jirikowski
    Institut für Anatomie II, Friedrich Schiller Universitat Jena, Germany
    J Chem Neuroanat 29:233-7. 2005
    ..Intrahypothalamic expression of ABP may be among the mechanisms necessary for rapid actions of steroids on hypothalamic neuroendocrine systems...
  74. ncbi Brain oxytocin correlates with maternal aggression: link to anxiety
    Oliver J Bosch
    Institute of Zoology, University of Regensburg, 93040 Regensburg, Germany
    J Neurosci 25:6807-15. 2005
    ..Therefore, differences in intracerebral release patterns of oxytocin, rather than differences at the level of oxytocin receptors, are critical for the regulation of maternal aggressive behavior...
  75. ncbi Chronic exposure to Delta9-tetrahydrocannabinol downregulates oxytocin and oxytocin-associated neurophysin in specific brain areas
    Elena Butovsky
    Department of Neurobiology, Weizmann Institute of Science, 76100 Rehovot, Israel
    Mol Cell Neurosci 31:795-804. 2006
    ..As OT is known to inhibit development of drug tolerance and attenuate withdrawal symptoms, we suggest that OT downregulation could play a role during the establishment of the chronic effects of Delta9-THC...
  76. pmc Cocaine treatment alters oxytocin receptor binding but not mRNA production in postpartum rat dams
    T M Jarrett
    Department of Psychiatry, The University of North Carolina at Chapel Hill, CB 7096, 436 Taylor Hall, Chapel Hill, NC 27599 7096, USA
    Neuropeptides 40:161-7. 2006
    ..There was no significant change in OT mRNA production in the PVN following cocaine treatment...
  77. ncbi Effects of Morris water maze testing on the neuroendocrine stress response and intrahypothalamic release of vasopressin and oxytocin in the rat
    Mario Engelmann
    Otto von Guericke Universitat Magdeburg, Institut für Medizinische Neurobiologie, Leipziger Str 44, D 39120 Magdeburg, Germany
    Horm Behav 50:496-501. 2006
    ..SON) nuclei were collected in order to monitor local release of the neuropeptides vasopressin (AVP) and oxytocin (OXT), respectively, during controllable swim stress...
  78. ncbi Interaction between oestrogen and oxytocin on hypothalamic-pituitary-adrenal axis activity
    T Ochedalski
    Section on Endocrine Physiology, Developmental Endocrinology Branch, National Institutes of Child Health and Human Development, NIH, Bethesda, MD 20892, USA
    J Neuroendocrinol 19:189-97. 2007
    ....
  79. ncbi Dominant role of betagamma subunits of G-proteins in oxytocin-evoked burst firing
    Yu feng Wang
    Department of Cell Biology and Neuroscience, University of California, Riverside, Riverside, California 92521, USA
    J Neurosci 27:1902-12. 2007
    ..We conclude that G betagamma subunits play a dominant role in burst firing evoked by applied OT or by suckling...
  80. ncbi A role for oxytocin and 5-HT(1A) receptors in the prosocial effects of 3,4 methylenedioxymethamphetamine ("ecstasy")
    M R Thompson
    School of Psychology, University of Sydney, Griffith Taylor Building A18, Sydney, NSW, 2006, Australia
    Neuroscience 146:509-14. 2007
    ..Taken together, these results suggest that oxytocin release, stimulated by MDMA through 5-HT(1A) receptors, may play a key role in the prosocial effects of MDMA and underlie some of the reinforcing effects of the drug...
  81. ncbi Neuroanatomical and cellular substrates of hypergrooming induced by microinjection of oxytocin in central nucleus of amygdala, an experimental model of compulsive behavior
    S S Marroni
    Neurophysiology and Experimental Neuroethology Laboratory, Ribeirao Preto School of Medicine, University of Sao Paulo, Avenida Bandeirantes, Ribeirao Preto, Sao Paulo, Brazil
    Mol Psychiatry 12:1103-17. 2007
    ....
  82. ncbi Glucocorticoid modulation of atrial natriuretic peptide, oxytocin, vasopressin and Fos expression in response to osmotic, angiotensinergic and cholinergic stimulation
    F Lauand
    Department of Physiology, School of Medicine of Ribeirao Preto, University of Sao Paulo, Avenida dos Bandeirantes, 3900 Monte Alegre, CEP 14049 900 Ribeirao Preto, SP, Brazil
    Neuroscience 147:247-57. 2007
    ..The present data also suggest that these responses are modulated by glucocorticoids...
  83. pmc Prenatal stress generates deficits in rat social behavior: Reversal by oxytocin
    Paul R Lee
    Program in Neuroscience, University of Maryland School of Medicine, Baltimore, MD 21228, USA
    Brain Res 1156:152-67. 2007
    ..Furthermore, unpredictable prenatal stress exposure selectively degrades social interaction behaviors without increasing anxiety measures...
  84. ncbi Glucocorticoid modulation of neuronal activity and hormone secretion induced by blood volume expansion
    S G Ruginsk
    Departamento de Fisiologia, Faculdade de Medicina de Ribeirao Preto, Universidade de Sao Paulo, Brazil
    Exp Neurol 206:192-200. 2007
    ..However, this pattern of response was not observed for AVP cells, suggesting that dexamethasone is not likely to influence rapid release of AVP but seems to modulate the activation of these neurons in response to hypertonic BVE...
  85. ncbi Colocalization of oxytocin and phosphorylated form of elongation factor 2 in the rat hypothalamus
    Toru Fujisawa
    Department of Physiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700 8558, Japan
    Acta Med Okayama 61:161-6. 2007
    ..Moreover, phospho-EF2 and OT were colocalized in a part of the neurons in the PVN and SON. These results suggest that OT may be partially translated in the axons of neurons in the PVN and SON, and then secreted from the pituitary...
  86. ncbi Oxytocin ameliorates skin damage and oxidant gastric injury in rats with thermal trauma
    Sevgin Ozlem Iseri
    Marmara University, School of Medicine, Department of Physiology, Haydarpasa, Istanbul 34668, Turkey
    Burns 34:361-9. 2008
    ....
  87. pmc Selective oxytocin receptor activation in the ventrolateral portion of the ventromedial hypothalamus is required for mating-induced pseudopregnancy in the female rat
    Lesley E Northrop
    Department of Biology, Boston University, Boston, MA 02215, USA
    Endocrinology 149:836-42. 2008
    ..Together, our results suggest that OT release in the VMHvl mediates the effects of VCS on the induction of the PRL secretion needed to establish PSP...
  88. pmc Oxytocin-induced antinociception in the spinal cord is mediated by a subpopulation of glutamatergic neurons in lamina I-II which amplify GABAergic inhibition
    Jean Didier Breton
    Department Nociception and Pain, Institut des Neurosciences Cellulaires et Integratives, Unité Mixte de Recherche 7168, Centre National de la Recherche Scientifique Université Louis Pasteur, Strasbourg, France
    Mol Pain 4:19. 2008
    ....
  89. pmc Oxytocin-induced contractions within rat and rabbit ejaculatory tissues are mediated by vasopressin V1A receptors and not oxytocin receptors
    J Gupta
    Discovery Biology, Pfizer Global Research and Development, Sandwich, Kent, UK
    Br J Pharmacol 155:118-26. 2008
    ..The aim of this study was to determine the effect of oxytocin and AVP on peripheral tissues involved in ejaculation and to identify the receptor subtype(s) involved...
  90. doi Postnatal oxytocin treatment of spontaneously hypertensive male rats decreases blood pressure and body weight in adulthood
    Maria Petersson
    Department of Molecular Medicine and Surgery, Endocrine and Diabetes Unit, Karolinska Institutet, SE 171 76 Stockholm, Sweden
    Neurosci Lett 440:166-9. 2008
    ..128; p=0.10). Heart rate was equal in the two groups. The postnatally oxytocin-treated male SHR had a significantly lower body weight at the age of 5-8 weeks compared to the controls (ANOVA p=0.014)...
  91. pmc Impact of gestational cocaine treatment or prenatal cocaine exposure on early postpartum oxytocin mRNA levels and receptor binding in the rat
    M S McMurray
    Department of Psychology, The University of North Carolina at Chapel Hill, 436 Taylor Hall, CB 7096, Chapel Hill, NC 27599, USA
    Neuropeptides 42:641-52. 2008
    ....
  92. pmc Intergenerational effects of cocaine on maternal aggressive behavior and brain oxytocin in rat dams
    M S McMurray
    Department of Psychology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Stress 11:398-410. 2008
    ..Higher aggression in cocaine-reared next generation dams was associated with lower levels of oxytocin in the amygdala. Intergenerational effects of cocaine were apparent with respect to aggression and oxytocin system changes...
  93. pmc Complexity of neural mechanisms underlying overconsumption of sugar in scheduled feeding: involvement of opioids, orexin, oxytocin and NPY
    Pawel K Olszewski
    Department of Neuroscience, Functional Pharmacology, Uppsala University, BMC, Uppsala SE 75124, Sweden
    Peptides 30:226-33. 2009
    ..We conclude that scheduled consumption of sugar diets is associated with activity of a complex network of neuroregulators involving opioids, orexin, oxytocin and NPY...
  94. doi Phenylethanolamine N-methyltransferase gene expression in the heart and blood pressure response to oxytocin treatment in rats exposed to voluntary wheel running
    Jan Bakos
    Institute of Experimental Endocrinology, Slovak Academy of Sciences, Bratislava, Slovakia
    Ann N Y Acad Sci 1148:302-7. 2008
    ..In conclusion, voluntary wheel running failed to modify sensitivity to cardiovascular action of oxytocin but resulted in increased gene expression of PNMT in left, but not right, heart atrium in a running activity-dependent manner...
  95. doi Oxytocin pretreatment decreases oxytocin-induced myometrial contractions in pregnant rats in a concentration-dependent but not time-dependent manner
    Joyce K R S Magalhaes
    Department of Anesthesia and Pain Management, Mount Sinai Hospital, Toronto, Canada
    Reprod Sci 16:501-8. 2009
    ....
  96. doi Vasopressin administration into the paraventricular nucleus normalizes plasma oxytocin and corticosterone levels in Brattleboro rats
    Dora Zelena
    Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, Hungary
    Endocrinology 150:2791-8. 2009
    ..Thus, endogenous vasopressin released within the PVN is likely to act as a paracrine signal to facilitate the return of plasma oxytocin and corticosterone to basal levels after acute stressor exposure...
  97. doi Differential effect of neocuproine, a copper(I) chelator, on contractile activity in isolated ovariectomized non-pregnant rat, pregnant rat and pregnant human uterus
    Eda Karabal Kumcu
    Department of Pharmacology, School of Medicine, University of Cukurova, Adana, Turkey
    Eur J Pharmacol 605:158-63. 2009
    ..These findings suggest that neocuproine can affect the uterus contractile activity by modulation purinergic excitatory responses and that copper(I)-sensitive mechanisms may play a role in this effect...
  98. doi Estradiol upregulates the expression of oxytocin receptor in colon in rats
    Mei Feng
    Department of Physiology, Medical School of Shandong University, Jinan 250012, China
    Am J Physiol Endocrinol Metab 296:E1059-66. 2009
    ..OTR was located in myenteric plexus of colon. These results suggested that E(2) increased the excitatory effect of OT on colon motility by upregulating the expression of OTR in myenteric plexus...
  99. ncbi Oxytocin in the cardiovascular responses to stress
    A Wsol
    Department of Experimental and Clinical Physiology, Medical University of Warsaw, Poland
    J Physiol Pharmacol 59:123-7. 2008
    ..The study provides evidence that stimulation of the brain oxytocin receptors by endogenous oxytocin plays significant role in inhibition of cardiovascular responses to stress...
  100. doi Cardiac sympatho-excitatory action of PVN-spinal oxytocin neurones
    Zhuo Yang
    Medical College, University of Nankai, Tianjin 300071, PR China
    Auton Neurosci 147:80-5. 2009
    ..v. atropine but were abolished by i.v. esmolol. It is concluded that there is a population of paraventricular-spinal oxytocin neurones that excite cardiac sympathetic preganglionic neurones controlling heart rate...
  101. doi Involvement of oxytocin and its receptor in nociceptive modulation in the central nucleus of amygdala of rats
    Yi Han
    Neurobiology Laboratory and State Key Laboratory of Biomembrane and Membrane Biotechnology, College of Life Sciences, Peking University, Beijing 100871, People s Republic of China
    Neurosci Lett 454:101-4. 2009
    ..The present study demonstrated that oxytocin and its receptors are involved in nociceptive modulation in the CeA of rats...