Oprk1

Summary

Gene Symbol: Oprk1
Description: opioid receptor, kappa 1
Alias: kappa-type opioid receptor, K-OR-1, KOR-1
Species: rat

Top Publications

  1. doi Gonadal hormones decrease temporomandibular joint kappa-mediated antinociception through a down-regulation in the expression of kappa opioid receptors in the trigeminal ganglia
    Juliana T Clemente-Napimoga
    Laboratory of Orofacial Pain, Department of Physiology, Piracicaba Dental School, State University of Campinas, Brazil Laboratory of Biopathology and Molecular Biology, University of Uberaba, Brazil
    Eur J Pharmacol 617:41-7. 2009
  2. doi Plasticity of opioid receptors in the female periaqueductal gray: multiparity-induced increase in the activity of genes encoding for mu and kappa receptors and a post-translational decrease in delta receptor expression
    Elizabeth Teodorov
    Centro de Matemática, Computação e Cognição, Universidade Federal do ABC, Av Prof Dr Orlando Marques de Paiva 87, CEP 05508 900, Sao Paulo, Brazil
    J Mol Neurosci 43:175-81. 2011
  3. ncbi Preliminary study of the effects of morphine treatment on opioid receptor gene expression in brain structures of the female rat
    E Teodorov
    Departamento de Patologia, Faculdade de Medicina Veterinaria e Zootecnia, Universidade de Sao Paulo, Av Orlando Marques de Paiva, 87, Cidade Universitaria, 05508 900 Sao Paulo, Brazil
    Neuroscience 141:1225-31. 2006
  4. pmc dynorphin-kappa opioid receptor signaling partly mediates estrogen negative feedback effect on LH pulses in female rats
    Parvin Mostari
    Laboratory of Reproductive Science, Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya 464 8601, Japan
    J Reprod Dev 59:266-72. 2013
  5. doi Inhibitory effects of processed Aconiti tuber on morphine-induced conditioned place preference in rats
    Guiyun Wu
    Department of Anesthesiology, The First Affiliated Hospital, Sun Yat Sen University, 58 Zhongshan 2nd Road, Guangzhou, Guangdong 510080, China
    J Ethnopharmacol 136:254-9. 2011
  6. doi Electrical and manual acupuncture stimulation affect oestrous cyclicity and neuroendocrine function in an 5α-dihydrotestosterone-induced rat polycystic ovary syndrome model
    Yi Feng
    Institute of Neuroscience and Physiology, Department of Physiology, Sahlgrenska Academy, University of Gothenburg, Sweden
    Exp Physiol 97:651-62. 2012
  7. pmc Bi-phasic intensity-dependent opioid-mediated neural amplitude changes in the chinchilla cochlea: partial blockade by an N-Methyl-D-Aspartate (NMDA)-receptor antagonist
    Tony L Sahley
    Department of Health Sciences, Cleveland State University, Cleveland, Ohio 44115, United States
    Eur J Pharmacol 580:100-15. 2008
  8. pmc The kappa opioid receptor antagonist JDTic attenuates alcohol seeking and withdrawal anxiety
    Jesse R Schank
    Laboratory of Clinical and Translational Studies, National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD, USA
    Addict Biol 17:634-47. 2012
  9. ncbi Increased locomotor response to amphetamine induced by the repeated administration of the selective kappa-opioid receptor agonist U-69593
    José Antonio Fuentealba
    Department of Pharmacy, Faculty of Chemistry, Pontificia Universidad Catolica de Chile, Alameda, Santiago, Chile
    Synapse 61:771-7. 2007
  10. ncbi The effect of kappa opioid receptor antagonism on energy expenditure in the obese Zucker rat
    Patricia A Jarosz
    Wayne State University, College of Nursing, Detroit, Michigan 48202, USA
    Biol Res Nurs 8:294-9. 2007

Scientific Experts

  • S K Joshi
  • Tony L Sahley
  • A Rosin
  • C G Jolivalt
  • Patricia A Jarosz
  • R I Anderson
  • Michael K Pugsley
  • K A Berg
  • Glenn R Valdez
  • Louis R Lucas
  • Thiago M Cunha
  • Shaaban A Mousa
  • S W Rabkin
  • Jason N Peart
  • E Teodorov
  • Charles Chavkin
  • Rong Fan
  • Juan Li
  • Nai Jiang Liu
  • L F Felicio
  • Sumita Chakrabarti
  • Luis A Herraez-Baranda
  • Firas Sedki
  • Peter A Groblewski
  • Aline Fassini
  • Gang Yu
  • Abigail M Polter
  • Gregory S Parks
  • Jianming Pei
  • Shiori Minabe
  • Kei Ichiro Maeda
  • Jian Xiu
  • Jiaji Lin
  • Lijun Zhang
  • Parvin Mostari
  • Hiroko Tsukamura
  • Anthony L Berger
  • Chikaya Deura
  • R Camarini
  • Tatsuo Nakahara
  • Yoshihisa Uenoyama
  • Jesse R Schank
  • Zhenxiong Zhang
  • Yi Feng
  • Brendan M Walker
  • F Ivy Carroll
  • Xin Sun
  • Allison T Knoll
  • Kathryn A Nealey
  • Guiyun Wu
  • Elizabeth Teodorov
  • Alan David Kaye
  • Alan R Gintzler
  • A M Cortez
  • Gregory V Carr
  • Carolina da Silveira Scarpellini
  • B A S Reyes
  • Pai Peng
  • Juliana T Clemente-Napimoga
  • P A Luz
  • Carrie T Drake
  • José Antonio Fuentealba
  • Jing Bi
  • Michael R Bruchas
  • Rogelio Gonzalez-Sarmiento
  • Jose Carretero
  • Raquel E Rodriguez
  • Sachiko Tanaka
  • Vesna Vujić
  • Nopporn Jongkamonwiwat
  • L W Fan
  • Karolina Ploj
  • Jay P McLaughlin
  • América A Scopinho
  • Uri Shalev
  • Nicholas Schouela
  • Ingo Willuhn
  • Karine Eigenmann
  • Chad Zietz
  • Jessica Gelinas
  • Paul E M Phillips
  • Shannon Courchesne
  • Leonardo B M Resstel
  • Fernando M A Correa
  • Olivier Civelli
  • M M Bernardi
  • Lisa A Briand
  • Nicholas M Graziane
  • Julie A Kauer
  • Hui Yan

Detail Information

Publications69

  1. doi Gonadal hormones decrease temporomandibular joint kappa-mediated antinociception through a down-regulation in the expression of kappa opioid receptors in the trigeminal ganglia
    Juliana T Clemente-Napimoga
    Laboratory of Orofacial Pain, Department of Physiology, Piracicaba Dental School, State University of Campinas, Brazil Laboratory of Biopathology and Molecular Biology, University of Uberaba, Brazil
    Eur J Pharmacol 617:41-7. 2009
    ..Alternatively, they significantly reduce kappa-opioid receptor expression in the trigeminal ganglia...
  2. doi Plasticity of opioid receptors in the female periaqueductal gray: multiparity-induced increase in the activity of genes encoding for mu and kappa receptors and a post-translational decrease in delta receptor expression
    Elizabeth Teodorov
    Centro de Matemática, Computação e Cognição, Universidade Federal do ABC, Av Prof Dr Orlando Marques de Paiva 87, CEP 05508 900, Sao Paulo, Brazil
    J Mol Neurosci 43:175-81. 2011
    ..This study addresses the effects of multiple reproductive experiences on μ-, κ- and δ-opioid receptor (Oprm1, Oprk1, and Oprd1 respectively) gene activity and μ, κ and δ protein expression (MOR, KOR and DOR respectively) in the ..
  3. ncbi Preliminary study of the effects of morphine treatment on opioid receptor gene expression in brain structures of the female rat
    E Teodorov
    Departamento de Patologia, Faculdade de Medicina Veterinaria e Zootecnia, Universidade de Sao Paulo, Av Orlando Marques de Paiva, 87, Cidade Universitaria, 05508 900 Sao Paulo, Brazil
    Neuroscience 141:1225-31. 2006
    ..In chronic treatment, both Oprk1 and Oprm1 expression levels, that encoded kappa and mu-opioid receptor respectively, showed significant decreases ..
  4. pmc dynorphin-kappa opioid receptor signaling partly mediates estrogen negative feedback effect on LH pulses in female rats
    Parvin Mostari
    Laboratory of Reproductive Science, Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya 464 8601, Japan
    J Reprod Dev 59:266-72. 2013
    ..The treatment also did not affect mRNA levels of Pdyn and Oprk1 (KOR gene) in the ARC-median eminence region, but significantly increased the ARC kisspeptin immunoreactivity...
  5. doi Inhibitory effects of processed Aconiti tuber on morphine-induced conditioned place preference in rats
    Guiyun Wu
    Department of Anesthesiology, The First Affiliated Hospital, Sun Yat Sen University, 58 Zhongshan 2nd Road, Guangzhou, Guangdong 510080, China
    J Ethnopharmacol 136:254-9. 2011
    ..Preclinical studies also demonstrated that KOR agonists functionally attenuate addictive behaviors of morphine, such as conditioned place preference (CPP). Therefore, we hypothesize that PAT may inhibit morphine-induced CPP in rats...
  6. doi Electrical and manual acupuncture stimulation affect oestrous cyclicity and neuroendocrine function in an 5α-dihydrotestosterone-induced rat polycystic ovary syndrome model
    Yi Feng
    Institute of Neuroscience and Physiology, Department of Physiology, Sahlgrenska Academy, University of Gothenburg, Sweden
    Exp Physiol 97:651-62. 2012
    ..s. versus control animals). The mRNA expression of the opioid receptors Oprk1 and Oprm1 in the hypothalamic arcuate nucleus was lower in the EA group than in untreated control rats...
  7. pmc Bi-phasic intensity-dependent opioid-mediated neural amplitude changes in the chinchilla cochlea: partial blockade by an N-Methyl-D-Aspartate (NMDA)-receptor antagonist
    Tony L Sahley
    Department of Health Sciences, Cleveland State University, Cleveland, Ohio 44115, United States
    Eur J Pharmacol 580:100-15. 2008
    ..The role played by lateral efferent opioid neuromodulation at cochlear NMDA receptors, is discussed...
  8. pmc The kappa opioid receptor antagonist JDTic attenuates alcohol seeking and withdrawal anxiety
    Jesse R Schank
    Laboratory of Clinical and Translational Studies, National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD, USA
    Addict Biol 17:634-47. 2012
    ..Our results provide additional evidence for the involvement of KOR in regulation of alcohol-related behaviors and provide support for KOR antagonists, including JDTic, to be evaluated as medications for alcoholism...
  9. ncbi Increased locomotor response to amphetamine induced by the repeated administration of the selective kappa-opioid receptor agonist U-69593
    José Antonio Fuentealba
    Department of Pharmacy, Faculty of Chemistry, Pontificia Universidad Catolica de Chile, Alameda, Santiago, Chile
    Synapse 61:771-7. 2007
    ..These results suggest that long-term effect of KOR activation results in facilitation of amphetamine-induced DA extracellular levels in the NAc accompanied by sensitization of amphetamine-induced increase in locomotor activity...
  10. ncbi The effect of kappa opioid receptor antagonism on energy expenditure in the obese Zucker rat
    Patricia A Jarosz
    Wayne State University, College of Nursing, Detroit, Michigan 48202, USA
    Biol Res Nurs 8:294-9. 2007
    ..Reduction in body weight as a result of KOR inhibition in this study was related to a decrease in food intake but not related to an increase in energy expended or activity...
  11. pmc Behavioral meaningful opioidergic stimulation activates kappa receptor gene expression
    E Teodorov
    Centro de Matemática, Computação e Cognição, Universidade Federal do ABC, Sao Paulo, SP, Brasil
    Braz J Med Biol Res 45:982-7. 2012
    ..kappa-opioid receptor agonist U69593 into the dorsal subcutaneous region of animals on maternal behavior and on Oprk1 gene activity in the PAG of female rats...
  12. ncbi Kappa opioid receptors in the rostral ventromedial medulla of male and female rats
    Carrie T Drake
    Department of Neurology and Neuroscience, Weill Medical College of Cornell University, New York, New York 10021, USA
    J Comp Neurol 500:465-76. 2007
    ..Altering the balance between pre- and postsynaptic receptive sites may underlie differences in the effects of KOR agonists on nociceptive responses in males and females...
  13. ncbi Dynorphin A, kappa opioid receptors and the antinociceptive efficacy of asimadoline in streptozotocin-induced diabetic rats
    C G Jolivalt
    Department of Pathology, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0612, USA
    Diabetologia 49:2775-85. 2006
    ..We investigated spinal and peripheral kappa opioid systems in diabetic rats...
  14. pmc Kappa opioid receptor activation of p38 MAPK is GRK3- and arrestin-dependent in neurons and astrocytes
    Michael R Bruchas
    Department of Pharmacology, University of Washington, 1959 Pacific Avenue N E, Seattle, WA 98195, USA
    J Biol Chem 281:18081-9. 2006
    ..Furthermore, in striatal neurons, the kappa-mediated phospho-p38 labeling was colocalized with arrestin3. These findings suggest that KOR may activate p38 MAPK in brain by a GRK3 and arrestin-dependent mechanism...
  15. pmc Affective cue-induced escalation of alcohol self-administration and increased 22-kHz ultrasonic vocalizations during alcohol withdrawal: role of kappa-opioid receptors
    Anthony L Berger
    Laboratory of Alcoholism and Addictions Neuroscience, Department of Psychology, Pullman, WA, USA
    Neuropsychopharmacology 38:647-54. 2013
    ..Taken together, this study implicates negative affective states induced by both alcohol withdrawal and conditioned stimuli as being produced, in part, by activity of the DYN/KOR system...
  16. ncbi Effect of exogenous kappa-opioid receptor activation in rat model of myocardial infarction
    Jason N Peart
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, Wisconsin 53222, USA
    J Cardiovasc Pharmacol 43:410-5. 2004
    ..These data demonstrate that KOR activation provides a similar degree of infarct size reduction as DOR activation. KOR agonists also reduced arrhythmogenesis; however, these responses appear to be independent of KOR activation...
  17. doi Role of κ-opioid receptor in hypoxic pulmonary artery hypertension and its underlying mechanism
    Lijun Zhang
    Department of Physiology, National Key Discipline of Cell Biology, Fourth Military Medical University, China
    Am J Ther 20:329-36. 2013
    ..This increase of κ-OR expression was both enhanced by U50,488H and abolished by nor-BNI. The results demonstrate that U50,488H attenuates HPH through both the stimulation and upregulation of κ-ORs. ..
  18. doi Treatment with steroid hormones and morphine alters general activity, sexual behavior, and opioid gene expression in female rats
    E Teodorov
    Centro de Matemática, Computação e Cognição, Universidade Federal do ABC, Av dos Estados, 5001, Brazil
    Life Sci 104:47-54. 2014
    ....
  19. doi An examination of the cardiac actions of PD117,302, a κ-opioid receptor agonist
    Michael K Pugsley
    Department of Global Safety Pharmacology and Toxicology, Janssen Pharmaceuticals LLC, Raritan, NJ 08869, United States Electronic address
    Eur J Pharmacol 761:330-40. 2015
    ..Transient outward and sustained outward K(+) currents were blocked by PD117,302. Thus, the ECG changes and antiarrhythmic effects observed in vivo result from direct blockade of multiple cardiac ion channels. ..
  20. doi κ-opioid receptors in the infralimbic cortex modulate the cardiovascular responses to acute stress
    Aline Fassini
    Department of Pharmacology of the School of Medicine of Ribeirão Preto, University of Sao Paulo, Ribeirao Preto, Sao Paulo, Brazil
    Exp Physiol 100:377-87. 2015
    ..In conclusion, κ-opioid receptors in the IL modulate pressor and tachycardiac responses caused by RS, suggesting a facilitatory role of this structure in this aversive situation...
  21. pmc Identification of neuropeptide receptors expressed by melanin-concentrating hormone neurons
    Gregory S Parks
    Department of Pharmacology, University of California Irvine, Irvine, California, 92697 Department of Developmental and Cell Biology, University of California Irvine, Irvine, California, 92697
    J Comp Neurol 522:3817-33. 2014
    ..Surprisingly, several receptors thought to regulate MCH neurons displayed minimal colocalization with MCH, suggesting that they may not directly regulate the MCH system...
  22. pmc Poststress block of kappa opioid receptors rescues long-term potentiation of inhibitory synapses and prevents reinstatement of cocaine seeking
    Abigail M Polter
    Department of Molecular Pharmacology, Physiology and Biotechnology, Brown University, Providence, Rhode Island
    Biol Psychiatry 76:785-93. 2014
    ..Our studies have shown that exposure to acute stress blocks this LTP and that reversal of the block of LTPGABA is correlated with prevention of stress-induced reinstatement of cocaine-seeking behavior...
  23. pmc Repeated stress exposure causes strain-dependent shifts in the behavioral economics of cocaine in rats
    Peter A Groblewski
    Department of Pharmacology, University of Washington, Seattle, WA, USA
    Addict Biol 20:297-301. 2015
    ..Thus, R-FSS exposure had strain-dependent effects on cocaine responding during the threshold procedure, and the stress effects on cocaine valuation exhibited by Wistar, but not WKY, required intact KOR signaling. ..
  24. ncbi Alterations in kappa opioid receptor mRNA levels in the paraventricular nucleus of the hypothalamus by stress and sex steroids
    R Y Yukhananov
    Department of Cell Biology, Neurobiology and Anatomy, Loyola University Medical Center, Maywood, IL 60153, USA
    Neuroreport 7:1690-4. 1996
    ..Taken together, these data indicate that kOR mRNA levels are under estrogenic control and up-regulated in a stressor specific fashion...
  25. doi A role for kappa-, but not mu-opioid, receptor activation in acute food deprivation-induced reinstatement of heroin seeking in rats
    Firas Sedki
    Department of Psychology, Center for Studies in Behavioral Neurobiology Groupe de Recherche en Neurobiologie Comportementale, Concordia University, Montreal, Quebec, Canada
    Addict Biol 20:423-32. 2015
    ..These results support the hypothesis that activation of KOR, but not MOR, is critically involved in stress-induced reinstatement of drug seeking. ..
  26. pmc Chronic peripheral administration of kappa-opioid receptor antagonist advances puberty onset associated with acceleration of pulsatile luteinizing hormone secretion in female rats
    Tatsuo Nakahara
    Graduate School of Medicine, Nagoya University, Nagoya 466 8550, Japan
    J Reprod Dev 59:479-84. 2013
    ....
  27. ncbi Downregulation of kappa opioid receptor mRNA levels by chronic ethanol and repetitive cocaine in rat ventral tegmentum and nucleus accumbens
    A Rosin
    Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden
    Neurosci Lett 275:1-4. 1999
    ..In the NAc, the strongest decrease was observed in the 'binge' cocaine group. This profound decrease of KOR mRNA in regions important for brain reward suggests a potential role of the KOR system in the abuse of cocaine and ethanol...
  28. ncbi kappa -opioid receptor agonists modulate visceral nociception at a novel, peripheral site of action
    S K Joshi
    Department of Pharmacology, College of Medicine, The University of Iowa, Iowa City 52242, USA
    J Neurosci 20:5874-9. 2000
    ..The present results support the existence of a non-kappa-opioid receptor site of action localized in the colon...
  29. ncbi Tyrosine phosphorylation of the kappa -opioid receptor regulates agonist efficacy
    S M Appleyard
    Department of Pharmacology and the Neurobiology Program, University of Washington, Seattle, Washington 98195 7280, USA
    J Biol Chem 275:38281-5. 2000
    ..Thus, tyrosine phosphorylation may provide an important mechanism for modulation of G protein-coupled receptor signaling...
  30. ncbi Dynorphin A(1-17)-induced feeding: pharmacological characterization using selective opioid antagonists and antisense probes in rats
    Robert M Silva
    Department of Psychology and Neuropsychology Doctoral Sub Program, City University of New York, Flushing, New York 11367, USA
    J Pharmacol Exp Ther 301:513-8. 2002
    ..These converging antagonist and AS ODN data firmly implicate the kappa(1)-opioid receptor and the KOR-1 and KOR-3/ORL-1 opioid receptor genes in the mediation of dynorphin-induced feeding...
  31. doi Effects of acute and repeated morphine treatment on κ-opioid receptor protein levels in mesocorticolimbic system
    Gang Yu
    Beijing Institute of Pharmacology and Toxicology, Beijing, People s Republic of China
    J Recept Signal Transduct Res 34:44-7. 2014
    ..Here, we further investigated the effects of morphine on protein levels of κ-opioid receptor in this reward-related circuitry...
  32. pmc Allosteric interactions between δ and κ opioid receptors in peripheral sensory neurons
    Kelly A Berg
    Department of Pharmacology, University of Texas Health Science Center, San Antonio, TX 78229, USA
    Mol Pharmacol 81:264-72. 2012
    ....
  33. doi Effects of recovery from immobilization stress on striatal preprodynorphin- and kappa opioid receptor-mRNA levels of the male rat
    Louis R Lucas
    Department of Biology, Loyola University Chicago, Chicago, IL 60660, USA
    Physiol Behav 104:972-80. 2011
    ....
  34. pmc Stimulation of peripheral kappa opioid receptors inhibits inflammatory hyperalgesia via activation of the PI3Kγ/AKT/nNOS/NO signaling pathway
    Thiago M Cunha
    Department of Pharmacology, School of Medicine of Ribeirao Preto University of Sao Paulo, Av, Bandeirantes, 3900, 14049 900, Ribeirao Preto SP, Brazil
    Mol Pain 8:10. 2012
    ..In the present study, the effect of the peripheral activation of KORs on PGE(2)-induced ongoing hyperalgesia was investigated. The mechanisms involved were also evaluated...
  35. pmc κ-opioid receptors are implicated in the increased potency of intra-accumbens nalmefene in ethanol-dependent rats
    Kathryn A Nealey
    Laboratory of Alcoholism and Addictions Neuroscience, Department of Psychology, Washington State University, Mail Code 644820, Pullman, WA 99164 4820, USA
    Neuropharmacology 61:35-42. 2011
    ....
  36. pmc κ opioid regulation of anxiety-like behavior during acute ethanol withdrawal
    Glenn R Valdez
    Department of Psychology, Grand Valley State University, Allendale, MI, United States
    Pharmacol Biochem Behav 102:44-7. 2012
    ....
  37. doi The effects of κ-opioid receptor on stretch-induced electrophysiological changes in infarcted rat hearts
    Jian Xiu
    Department of Cardiology, The First Hospital of Harbin Medical University, Harbin, Heilongjiang Province, China
    Am J Med Sci 345:129-35. 2013
    ..This study aims to determine the effects of the κ-OR on stretch-induced electrophysiological changes after acute MI...
  38. pmc Activation of opioid μ-receptors, but not δ- or κ-receptors, switches pulmonary C-fiber-mediated rapid shallow breathing into an apnea in anesthetized rats
    Zhenxiong Zhang
    Pathophysiology Program, Lovelace Respiratory Research Institute, Albuquerque, NM 87108, United States
    Respir Physiol Neurobiol 183:211-7. 2012
    ..Our results suggest that activating μ-receptors is capable of turning the PCF-mediated RSB into an apnea, at least partly, via facilitating PCFs' activity and this switching effect appears independent of the released histamine...
  39. doi κ-Opioid receptor stimulation modulates TLR4/NF-κB signaling in the rat heart subjected to ischemia-reperfusion
    Jiaji Lin
    Department of Physiology, National Key Discipline of Cell Biology, Fourth Military Medical University, Xi an, 710032 Shaanxi Province, PR China
    Cytokine 61:842-8. 2013
    ..These data provide evidence for the first time that κ-opioid receptor stimulation inhibits TLR4/NF-κB signaling in the rat heart subjected to MI/R...
  40. ncbi Differential coupling of mu-, delta-, and kappa-opioid receptors to G alpha16-mediated stimulation of phospholipase C
    J W Lee
    Department of Biology and Biotechnology Research Institute, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, China
    J Neurochem 70:2203-11. 1998
    ..5- to almost 17-fold. These findings suggest that the promiscuous G alpha16 can in fact discriminate among different receptors and that such preferential interaction might in part be due to the abundance of receptors...
  41. pmc Spinal synthesis of estrogen and concomitant signaling by membrane estrogen receptors regulate spinal κ- and μ-opioid receptor heterodimerization and female-specific spinal morphine antinociception
    Nai Jiang Liu
    State University of New York, Downstate Medical Center, Brooklyn, New York 11203, USA
    J Neurosci 31:11836-45. 2011
    ..We suggest that KOR/MOR is a molecular switch that shifts the function of KOR and thereby endogenous dynorphin from pronociceptive to antinociceptive. KOR/MOR could thus serve as a novel molecular target for pain management in women...
  42. pmc Kappa opioid receptor signaling in the basolateral amygdala regulates conditioned fear and anxiety in rats
    Allison T Knoll
    Department of Psychiatry, Behavioral Genetics Laboratory, Harvard Medical School, McLean Hospital, Belmont, Massachusetts, USA
    Biol Psychiatry 70:425-33. 2011
    ..Here, we sought to identify neural circuits that mediate KOR system effects on fear and anxiety in rats...
  43. doi Blockade of central kappa-opioid receptors inhibits the antidipsogenic effect of interleukin-1beta
    P A Luz
    Department of Biological Sciences, State University of Southwest Bahia, 45200 000 Jequié, Bahia, Brazil
    Neuropeptides 43:93-103. 2009
    ..In summary, the data shown in the present study clearly show that the antidipsogenic effect observed in rats following third ventricle injections of IL-1beta depend on the functional integrity of a brain kappa-opioid-dependent component...
  44. ncbi Evidence of involvement of the nNOS and the kappa-opioid receptor in the same intracellular network of the rat periaqueductal gray that controls morphine tolerance and dependence
    Luis A Herraez-Baranda
    Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Salamanca, Campus Unamuno, Avenue Alfonso X el Sabio s n, Salamanca 37007, Spain
    Brain Res Mol Brain Res 137:166-73. 2005
    ..Besides, we examined the colocalization of both molecules. Our results point to an involvement of KOR and nNOS in the same intracellular network that controls the development of morphine tolerance and dependence...
  45. ncbi Cloning and expression of a cDNA for the rat kappa-opioid receptor
    M Minami
    Department of Pharmacology, Faculty of Pharmaceutical Sciences, Kyoto University, Japan
    FEBS Lett 329:291-5. 1993
    ..Northern blot analysis demonstrated that kappa-opioid receptor mRNA is expressed in a regionally specific manner in rat brain...
  46. pmc Cloning and pharmacological characterization of a rat kappa opioid receptor
    F Meng
    Mental Health Research Institute, University of Michigan, Ann Arbor 48109
    Proc Natl Acad Sci U S A 90:9954-8. 1993
    ..These observations indicate that we have cloned a cDNA encoding a rat kappa receptor of the kappa 1 subtype...
  47. pmc Molecular cloning of a rat kappa opioid receptor reveals sequence similarities to the mu and delta opioid receptors
    Y Chen
    Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis 46202
    Biochem J 295:625-8. 1993
    ....
  48. pmc Molecular cloning and expression of a rat kappa opioid receptor
    S Li
    Department of Pharmacology, Temple University, School of Medicine, Philadelphia, PA
    Biochem J 295:629-33. 1993
    ..Thus, RKOR-1 represents an opioid receptor with kappa characteristics...
  49. ncbi cDNA cloning and pharmacological characterization of an opioid receptor with high affinities for kappa-subtype-selective ligands
    M Nishi
    International Institute for Advanced Studies, Kyoto, Japan
    FEBS Lett 330:77-80. 1993
    ..RNA blot hybridization analysis indicated that ROR-D mRNA is distributed in cerebrum and brainstem but not in cerebellum...
  50. ncbi Stereoselective interaction of ketamine with recombinant mu, kappa, and delta opioid receptors expressed in Chinese hamster ovary cells
    K Hirota
    University Department of Anaesthesia, Leicester Royal Infirmary, United Kingdom
    Anesthesiology 90:174-82. 1999
    ....
  51. pmc G-protein-coupled receptor heterodimerization modulates receptor function
    B A Jordan
    Department of Pharmacology, New York University School of Medicine, New York 10016, USA
    Nature 399:697-700. 1999
    ..Furthermore, the kappa-delta heterodimer synergistically binds highly selective agonists and potentiates signal transduction. Thus, heterodimerization of these GPCRs represents a novel mechanism that modulates their function...
  52. ncbi Phosphorylation of a carboxyl-terminal serine within the kappa-opioid receptor produces desensitization and internalization
    Jay P McLaughlin
    Department of Pharmacology, University of Washington School of Medicine, Seattle, Washington 98195 7280, USA
    J Biol Chem 278:34631-40. 2003
    ..These results demonstrate that GRK-mediated phosphorylation of serine 369 mediates rat KOR desensitization and internalization...
  53. ncbi Long-term effects on brain opioid and opioid receptor like-1 receptors after short periods of maternal separation in rats
    Karolina Ploj
    Department of Pharmaceutical Biosciences, Division of Pharmacology, Box 591, Uppsala University, SE 751 24 Uppsala, Sweden
    Neurosci Lett 345:195-7. 2003
    ....
  54. ncbi The presence of opioid receptors in rat inner ear
    Nopporn Jongkamonwiwat
    Neuro Behavioural Biology Center, Institute of Science and Technology for Research and Development, Mahidol University, 73170 Nakornpathom, Thailand
    Hear Res 181:85-93. 2003
    ..These findings are the first report of the presence of all three classical opioid receptors in the inner ear and suggest that these receptors may have both presynaptic and postsynaptic roles...
  55. ncbi Changes in the brain kappa-opioid receptor levels of rats in withdrawal from physical dependence upon butorphanol
    L W Fan
    Department of Pharmacology and Toxicology, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS 39216, USA
    Neuroscience 121:1063-74. 2003
    ....
  56. ncbi Methionine-enkephalin stimulates hydrogen peroxide and nitric oxide production in rat peritoneal macrophages: interaction of mu, delta and kappa opioid receptors
    Vesna Vujić
    Institute of Chemistry, School of Medicine, Belgrade, Serbia and Montenegro
    Neuroimmunomodulation 11:392-403. 2004
    ..Since an endogenous opioid ligand might interact with more than one type of opioid receptor, the receptor interaction determines its effect on a particular function...
  57. ncbi Kappa opioid receptor is expressed in the rat cerebellar cortex
    Luis A Herraez-Baranda
    Molecular Medicine Unit, Department of Medicine, Faculty of Medicine, University of Salamanca, Spain
    Cell Tissue Res 320:223-8. 2005
    ..This work contributes to the deeper knowledge of the mechanisms that are involved in cerebellar function and may lead to a better understanding of the relationships between nociceptive activity and drug abuse potential...
  58. pmc Formation of mu-/kappa-opioid receptor heterodimer is sex-dependent and mediates female-specific opioid analgesia
    Sumita Chakrabarti
    State University of New York, Downstate Medical Center, Brooklyn, NY 11203, USA
    Proc Natl Acad Sci U S A 107:20115-9. 2010
    ..Spinal cord MOR/KOR heterodimers represent a unique pharmacological target for female-specific pain control...
  59. ncbi Butorphanol dependence increases hippocampal kappa-opioid receptor gene expression
    Sachiko Tanaka
    Department of Biochemical Toxicology, School of Pharmaceutical Science, Showa University, Tokyo, Japan
    J Neurosci Res 82:255-63. 2005
    ....
  60. pmc Axonal mRNA transport and localized translational regulation of kappa-opioid receptor in primary neurons of dorsal root ganglia
    Jing Bi
    Department of Pharmacology, University of Minnesota Medical School, 6 120 Jackson Hall, 321 Church Street Southeast, Minneapolis, MN 55455, USA
    Proc Natl Acad Sci U S A 103:19919-24. 2006
    ....
  61. ncbi Endogenous kappa opioids mediate the action of brain angiotensin II to increase blood pressure
    Simon W Rabkin
    University of British Columbia, 9th Floor 2775 Laurel St, Vancouver, BC, Canada V5Z 1M9
    Neuropeptides 41:411-9. 2007
    ....
  62. doi Activation of kappa-opioid receptors at reperfusion affords cardioprotection in both rat and mouse hearts
    Jason N Peart
    Heart Foundation Research Center, Griffith University, Gold Coast Mail Center, QLD, 9726, Australia
    Basic Res Cardiol 103:454-63. 2008
    ..In summary, kappa-ORs afford cardioprotection primarily when activated prior to and not after reperfusion. This protection may involve activation of the PI3 kinase (PI3K) pathway and mitochondrial (mito) K (ATP) channels...
  63. pmc Subcellular targeting of kappa-opioid receptors in the rat nucleus locus coeruleus
    B A S Reyes
    Department of Neurosurgery, Thomas Jefferson University, Farber Institute for Neurosciences, Philadelphia, Pennsylvania 19107, USA
    J Comp Neurol 512:419-31. 2009
    ..These data add to the growing literature showing that kappaORs can modulate diverse afferent signaling to the LC...
  64. ncbi Structure and expression of a rat kappa opioid receptor gene
    A G Yakovlev
    Department of Neurology, Georgetown University Medical Center, Washington, D C 20007
    J Biol Chem 270:6421-4. 1995
    ..The potential open reading frame that starts further upstream in KORx may lead to the translation of a variant KOR protein having a novel peptide sequence at its amino terminus...
  65. doi Distribution of kappa-opioid receptor in the pulmonary artery and its changes during hypoxia
    Pai Peng
    Department of Plastic Surgery, Xijing Hospital, Fourth Military Medical University, Xi an, China
    Anat Rec (Hoboken) 292:1062-7. 2009
    ..05). The present study has provided evidence for the first time of the precise location of kappa-ORs in PAs and PASMCs of rats and that hypoxia upregulates expression of kappa-ORs...
  66. doi Role of preoptic opioid receptors in the body temperature reduction during hypoxia
    Carolina da Silveira Scarpellini
    Department of Animal Morphology and Physiology, College of Agricultural and Veterinarian Sciences, Sao Paulo State University, Jaboticabal, SP, 14884 900, Brazil
    Brain Res 1286:66-74. 2009
    ..Our results indicate the kappa-opioid receptor in the AVPO is important for the reduction of Tb during hypoxia while the mu and delta receptors are involved in the increase of Tb during normoxia post-hypoxia...
  67. pmc Antidepressant-like effects of kappa-opioid receptor antagonists in Wistar Kyoto rats
    Gregory V Carr
    Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
    Neuropsychopharmacology 35:752-63. 2010
    ..These results support the use of the WKY rat as a model of affective disorders potentially involving KOR overactivity and provide more evidence that KOR antagonists could potentially be used as novel antidepressants...
  68. pmc Age-dependent effects of kappa-opioid receptor stimulation on cocaine-induced stereotyped behaviors and dopamine overflow in the caudate-putamen: an in vivo microdialysis study
    A M Cortez
    Department of Psychology, California State University, San Bernardino, CA 92407, USA
    Neuroscience 169:203-13. 2010
    ..This lack of functional maturity may explain why kappa-opioid receptor agonists frequently induce different behavioral effects in young and adult rats...
  69. doi Identification of mu- and kappa-opioid receptors as potential targets to regulate parasympathetic, sympathetic, and sensory neurons within rat intracardiac ganglia
    Shaaban A Mousa
    Department of Anesthesiology and Intensive Care Medicine, Charite University Berlin, Campus Virchow Klinikum and Campus Charite Mitte, 13353 Berlin, Germany
    J Comp Neurol 518:3836-47. 2010
    ..Thus, they may well play a role within the complex network for the integration of the heart's neuronal in- and output...