Nras

Summary

Gene Symbol: Nras
Description: neuroblastoma RAS viral oncogene homolog
Alias: GTPase NRas, neuroblastoma RAS viral (v-ras) oncogene homolog, neuroblastoma ras oncogene, transforming protein N-Ras
Species: rat

Top Publications

  1. pmc Selective role for RGS12 as a Ras/Raf/MEK scaffold in nerve growth factor-mediated differentiation
    Melinda D Willard
    Department of Pharmacology, University of North Carolina, Chapel Hill, NC 27599 7365, USA
    EMBO J 26:2029-40. 2007
  2. ncbi Identification of a new non-major histocompatibility complex genetic locus on chromosome 2 that controls disease severity in collagen-induced arthritis in rats
    P S Gulko
    National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, Maryland 20892, USA
    Arthritis Rheum 41:2122-31. 1998
  3. pmc RAS oncogene suppression induces apoptosis followed by more differentiated and less myelosuppressive disease upon relapse of acute myeloid leukemia
    Won Il Kim
    Department of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, USA
    Blood 113:1086-96. 2009
  4. ncbi Diabetes increases both N-ras and ets-1 expression during rat oral oncogenesis resulting in enhanced cell proliferation and metastatic potential
    Eleftherios Vairaktaris
    Department of Oral and Maxillofacial Surgery, University ofAthens Medical School, Athens, Greece
    In Vivo 21:615-21. 2007
  5. pmc Endogenous oncogenic Nras mutation initiates hematopoietic malignancies in a dose- and cell type-dependent manner
    Jinyong Wang
    McArdle Laboratory for Cancer Research, University of Wisconsin Madison, Madison, WI, USA
    Blood 118:368-79. 2011
  6. ncbi Loss of heterozygosity at the N-ras locus in 7,12-dimethylbenz[a] anthracene-induced rat leukemia
    M Osaka
    Department of Pathology, Faculty of Medicine, Kyoto University, Japan
    Mol Carcinog 18:206-12. 1997
  7. pmc Mutation of NRAS but not KRAS significantly reduces myeloma sensitivity to single-agent bortezomib therapy
    George Mulligan
    Takeda Pharmaceuticals International Co, Cambridge, MA
    Blood 123:632-9. 2014
  8. doi Role of Ras, ERK, and Akt in glucocorticoid-induced differentiation of embryonic rat somatotropes in vitro
    Wen Ming Lv
    The Department of Neurological Surgery, First Affiliated Hospital, Harbin Medical University, Harbin, 150001, People s Republic of China
    Mol Cell Biochem 391:67-75. 2014
  9. pmc Deficiency of β Common Receptor Moderately Attenuates the Progression of Myeloproliferative Neoplasm in NrasG12D/+ Mice
    Jingfang Zhang
    From the McArdle Laboratory for Cancer Research, University of Wisconsin Madison, Madison, Wisconsin 53705 and
    J Biol Chem 290:19093-103. 2015
  10. doi MEK1/2 dual-specificity protein kinases: structure and regulation
    Robert Roskoski
    Blue Ridge Institute for Medical Research, Horse Shoe, NC 28742, USA
    Biochem Biophys Res Commun 417:5-10. 2012

Scientific Experts

  • Robert Roskoski
  • M M Griffiths
  • Eleftherios Vairaktaris
  • A Walentinsson
  • Jinyong Wang
  • Francis S Willard
  • Melinda D Willard
  • Jingfang Zhang
  • Wen Ming Lv
  • George Mulligan
  • Jing Zhang
  • Yangang Liu
  • Juan Du
  • Jisun Lee
  • I Boulalas
  • Won Il Kim
  • Pamela Traynor
  • Jose P Vaque
  • Teresina Laragione
  • Xiaoyan Li
  • David P Siderovski
  • William D Snider
  • Sok Hyong Lee
  • Jinjin Guo
  • Ioannis N Mammas
  • R L Wilder
  • P S Gulko
  • Guangyao Kong
  • Erik A Ranheim
  • Shi Yun Dong
  • Pieter Sonneveld
  • Helgi van de Velde
  • Stephen J Blakemore
  • Yan Zhao
  • Guang Hui Zhang
  • Alessandra Di Bacco
  • Yu Zhang
  • Kenneth C Anderson
  • Hugues Bernard
  • David I Lichter
  • James R Berenson
  • Matthew Schu
  • Yu Cheng
  • Joseph B Bolen
  • Erik Koenig
  • Deborah Ricci
  • Guang Yang
  • Jesus F San Miguel
  • Paul G Richardson
  • Andrew J Dorner
  • Nibedita Chattopadhyay
  • Sundar Jagannath
  • Sagar Lonial
  • William Trepicchio
  • Allison Berger
  • Guo Zhong Li
  • Dixie Lee Esseltine
  • Edward A Stadtmauer
  • Bin Li
  • Rachel Neuwirth
  • Robert Z Orlowski
  • Myung Jeom Ryu
  • Zeyang Li
  • Benjamin Meline
  • Li Xuan Tan
  • Qiang Chang
  • Zhongde Wang
  • Erik Ranheim
  • Ken H Young
  • Young Joo Kim
  • Tae Gyu Choi
  • Sung Goo Chang
  • Seonmin Lee
  • Sung Soo Kim
  • Feng Hong
  • Kyu Jin Choi
  • Jin Man Cho
  • Joohun Ha
  • Min Jin Lim
  • Eunyoung Tak
  • Nathaniel A Sowa
  • A Zaravinos
  • Mark J Zylka
  • David A Largaespada
  • Channing J Der
  • Miechaleen D Diers
  • Meera Soundararajan
  • I Karyotis
  • Randall J Kimple
  • Declan A Doyle

Detail Information

Publications32

  1. pmc Selective role for RGS12 as a Ras/Raf/MEK scaffold in nerve growth factor-mediated differentiation
    Melinda D Willard
    Department of Pharmacology, University of North Carolina, Chapel Hill, NC 27599 7365, USA
    EMBO J 26:2029-40. 2007
    ..These data suggest that RGS12 may play a critical, and receptor-selective, role in coordinating Ras-dependent signals that are required for promoting and/or maintaining neuronal differentiation...
  2. ncbi Identification of a new non-major histocompatibility complex genetic locus on chromosome 2 that controls disease severity in collagen-induced arthritis in rats
    P S Gulko
    National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, Maryland 20892, USA
    Arthritis Rheum 41:2122-31. 1998
    ..To identify novel non-major histocompatibility complex (non-MHC) genetic loci controlling the severity of homologous rat type II collagen-induced arthritis (CIA)...
  3. pmc RAS oncogene suppression induces apoptosis followed by more differentiated and less myelosuppressive disease upon relapse of acute myeloid leukemia
    Won Il Kim
    Department of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, USA
    Blood 113:1086-96. 2009
    To study the oncogenic role of the NRAS oncogene (NRAS(G12V)) in the context of acute myeloid leukemia (AML), we used a Vav promoter-tetracycline transactivator (Vav-tTA)-driven repressible TRE-NRAS(G12V) transgene system in Mll-AF9 knock-..
  4. ncbi Diabetes increases both N-ras and ets-1 expression during rat oral oncogenesis resulting in enhanced cell proliferation and metastatic potential
    Eleftherios Vairaktaris
    Department of Oral and Maxillofacial Surgery, University ofAthens Medical School, Athens, Greece
    In Vivo 21:615-21. 2007
    ..The expression of N-ras and ets-1 proteins was investigated in an experimental model of chemically-induced carcinogenesis in normal and diabetic (type I) Sprague-Dawley rats...
  5. pmc Endogenous oncogenic Nras mutation initiates hematopoietic malignancies in a dose- and cell type-dependent manner
    Jinyong Wang
    McArdle Laboratory for Cancer Research, University of Wisconsin Madison, Madison, WI, USA
    Blood 118:368-79. 2011
    Both monoallelic and biallelic oncogenic NRAS mutations are identified in human leukemias, suggesting a dose-dependent role of oncogenic NRAS in leukemogenesis...
  6. ncbi Loss of heterozygosity at the N-ras locus in 7,12-dimethylbenz[a] anthracene-induced rat leukemia
    M Osaka
    Department of Pathology, Faculty of Medicine, Kyoto University, Japan
    Mol Carcinog 18:206-12. 1997
    ..We believe that this system provides a suitable model for studying a series of genetic alterations from the earliest stage of carcinogenesis that cannot be approached in human malignancies...
  7. pmc Mutation of NRAS but not KRAS significantly reduces myeloma sensitivity to single-agent bortezomib therapy
    George Mulligan
    Takeda Pharmaceuticals International Co, Cambridge, MA
    Blood 123:632-9. 2014
    ..New recurrent mutations were also identified, including in the PDGFRA and JAK3 genes. NRAS mutations were associated with a significantly lower response rate to single-agent bortezomib (7% vs 53% in ..
  8. doi Role of Ras, ERK, and Akt in glucocorticoid-induced differentiation of embryonic rat somatotropes in vitro
    Wen Ming Lv
    The Department of Neurological Surgery, First Affiliated Hospital, Harbin Medical University, Harbin, 150001, People s Republic of China
    Mol Cell Biochem 391:67-75. 2014
    ..05). Taken together, our results indicate that Ras, ERK, and Akt are key effectors in the glucocorticoid-induced differentiation of growth hormone-secreting cells...
  9. pmc Deficiency of β Common Receptor Moderately Attenuates the Progression of Myeloproliferative Neoplasm in NrasG12D/+ Mice
    Jingfang Zhang
    From the McArdle Laboratory for Cancer Research, University of Wisconsin Madison, Madison, Wisconsin 53705 and
    J Biol Chem 290:19093-103. 2015
    ..Here, we investigate this issue in a well characterized MP-CMML model induced by endogenous Nras(G12D/+) mutation...
  10. doi MEK1/2 dual-specificity protein kinases: structure and regulation
    Robert Roskoski
    Blue Ridge Institute for Medical Research, Horse Shoe, NC 28742, USA
    Biochem Biophys Res Commun 417:5-10. 2012
    ..MEK1 regulation is unusual in that S212 phosphorylation in its activation segment is inhibitory. Moreover, active ERK catalyzes a feedback inhibitory phosphorylation of MEK1 T292 that serves to downregulate the pathway...
  11. doi Proto-oncogenic H-Ras, K-Ras, and N-Ras are involved in muscle differentiation via phosphatidylinositol 3-kinase
    Jisun Lee
    Department of Biochemistry and Molecular Biology, Medical Research Center for Bioreaction to Reactive Oxygen Species and Biomedical Science Institute, Kyung Hee University, Seoul, Korea
    Cell Res 20:919-34. 2010
    ..In addition, PI3K pathway activation is associated with a concurrent suppression of the otherwise predominantly activated Raf/Mek/Erk pathway...
  12. pmc Regulator of G-protein signaling 14 (RGS14) is a selective H-Ras effector
    Francis S Willard
    Department of Pharmacology, University of North Carolina, Chapel Hill, North Carolina, United States of America
    PLoS ONE 4:e4884. 2009
    ..However, more recent data from mammals and Drosophila imply that, in vivo, RGS14 may instead be an effector of Ras...
  13. doi Activation of RAS family genes in urothelial carcinoma
    I Boulalas
    Department of Urology, Asklipieio General Hospital, Voula, Athens, Greece
    J Urol 181:2312-9. 2009
    ..Bladder cancer is the fifth most common malignancy in men in Western society. We determined RAS codon 12 and 13 point mutations and evaluated mRNA expression levels in transitional cell carcinoma cases...
  14. doi c-Myc inhibits Ras-mediated differentiation of pheochromocytoma cells by blocking c-Jun up-regulation
    Jose P Vaque
    Grupo de Biología Molecular del Cáncer, Dpto de Biología Molecular and Instituto de Biomedicina y Biotecnología de Cantabria, Universidad de Cantabria CSIC IDICAN, Santander, Spain
    Mol Cancer Res 6:325-39. 2008
    ..In conclusion, we describe a novel interplay between c-Myc and c-Jun that controls the ability of Ras to trigger the differentiation program of pheochromocytoma cells...
  15. pmc Cia5d regulates a new fibroblast-like synoviocyte invasion-associated gene expression signature
    Teresina Laragione
    Laboratory of Experimental Rheumatology, Center for Genomics and Human Genetics, Feinstein Institute for Medical Research, Manhasset, New York 11030, USA
    Arthritis Res Ther 10:R92. 2008
    ..In the present study we aimed to characterize the pattern of gene expression that correlates with differences in invasion in order to identify pathways regulated by the Cia5d locus...
  16. pmc An increase in N-Ras expression is associated with development of hormone refractory prostate cancer in a subset of patients
    Pamela Traynor
    University Department of Surgery, Division of Cancer Sciences and Molecular Pathology, Glasgow Royal Infirmary, Glasgow, UK
    Dis Markers 24:157-65. 2008
    ..010) and proliferation index (Ki67, p=0.02). These results suggest that in a subgroup patients N-Ras expression is associated with development of hormone refractory prostate cancer via activation of the MAP kinase cascade...
  17. ncbi Possible involvement of c-myc but not ras genes in hepatocellular carcinomas developing after spontaneous hepatitis in LEC rats
    Y Fujimoto
    Carcinogenesis Division, National Cancer Center Research Institute, Tokyo, Japan
    Mol Carcinog 4:269-74. 1991
    ....
  18. ncbi 16-kDa prolactin inhibits endothelial cell migration by down-regulating the Ras-Tiam1-Rac1-Pak1 signaling pathway
    Sok Hyong Lee
    Department of Immunology, Baylor College of Medicine, Houston, TX 77030, USA
    Cancer Res 67:11045-53. 2007
    ..Thus, 16k PRL inhibits cell migration by blocking the Ras-Tiam1-Rac1-Pak1 signaling pathway in endothelial cells...
  19. ncbi Persistent nicotine treatment potentiates amplification of the dihydrofolate reductase gene in rat lung epithelial cells as a consequence of Ras activation
    Jinjin Guo
    Cancer Research Center, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Biol Chem 280:30422-31. 2005
    ..Under p53-deficient conditions, the establishment of a full oncogenic transformation, in response to long term nicotine exposure, is achieved through the cooperation of multiple signaling pathways...
  20. ncbi Transcriptional activation of H- and N-ras oncogenes in human cervical cancer
    Ioannis N Mammas
    Laboratory of Virology, Medical School, University of Crete, Heraklion 71100, Crete, Greece
    Gynecol Oncol 92:941-8. 2004
    ..The purpose of this study was to evaluate the quantitative and qualitative changes of expression of the ras family genes in the development of human cervical cancer...
  21. ncbi Ras gene mutations in 7,12-dimethylbenz[a]anthracene (DMBA)-induced rat sarcomas
    A Walentinsson
    Department of Cell and Molecular Biology Genetics, Goteborg University, Box 462, SE 405 30, Gothenburg, Sweden
    Cancer Lett 166:47-53. 2001
    ..DMBA erythroleukemias display RNO2 abnormalities, which in this case were closely correlated to mutations in the Nras oncogene located in RNO2q34...
  22. ncbi Mapping autoimmunity genes
    M M Griffiths
    Veteran Affairs Medical Center, Department of Medicine, University of Utah School of Medicine, Salt Lake City, UI, USA
    Curr Opin Immunol 11:689-700. 1999
    ..Candidate genes are being identified. Polymorphic alleles associated with these chromosomal segments may represent predisposing genetic elements common to a number of human diseases with very different clinical presentations...
  23. ncbi Localization in rats of genetic loci regulating susceptibility to experimental erosive arthritis and related autoimmune diseases
    R L Wilder
    Inflammatory Joint Diseases Section, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Transplant Proc 31:1585-8. 1999
  24. ncbi Sequence of the Escherichia coli K-12 edd and eda genes of the Entner-Doudoroff pathway
    A T Carter
    AFRC Institute of Food Research, Norwich Research Park, UK
    Gene 130:155-6. 1993
    ..These data are compared with those of Egan et al. [J. Bacteriol. 174 (1992) 4638-4646] and important differences were noted...
  25. ncbi The function of GRB2 in linking the insulin receptor to Ras signaling pathways
    E Y Skolnik
    Department of Pharmacology, New York University Medical Center, NY 10016
    Science 260:1953-5. 1993
    ....
  26. ncbi The rat N-ras gene; interference of pseudogenes with the detection of activating point mutations
    H J van Kranen
    Laboratory of Carcinogenesis and Mutagenesis, National Institute of Public Health and Environmental Protection, RIVM, Bilthoven, The Netherlands
    Carcinogenesis 15:307-11. 1994
    ..Taken together, our results demonstrate that intron-specific amplification is a prerequisite for the unambiguous detection of activating point mutations in the N-ras gene of the rat...
  27. ncbi Sequencing analysis of Ha-, Ki-, and N-ras genes in rat urinary bladder tumors induced by N-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide (FANFT) and sodium saccharin
    T Masui
    Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha 68198
    Teratog Carcinog Mutagen 13:225-33. 1993
    ..These results suggest the involvement of activated Ha-ras gene, but not Ki-N or N-ras gene, in rat urinary bladder carcinogenesis induced by FANFT. Subsequent sodium saccharin administration did not affect the changes in Ha-ras gene...
  28. pmc Characterization of c-Ki-ras and N-ras oncogenes in aflatoxin B1-induced rat liver tumors
    G McMahon
    Division of Toxicology, Whitaker College, Cambridge, MA
    Proc Natl Acad Sci U S A 87:1104-8. 1990
    ..The presence of a potential germ-line oncogene may be related to the sensitivity of the Fischer rat strain to liver carcinogenesis by aflatoxin B1 and other chemical carcinogens...