Npw

Summary

Gene Symbol: Npw
Description: neuropeptide W
Alias: neuropeptide W, PPL8, prepro-Neuropeptide W polypeptide, preproprotein L8
Species: rat

Top Publications

  1. pmc Compromise of endogenous neuropeptide W production abrogates the dipsogenic and pressor effects of angiotensin II in adult male rats
    A T Pate
    Department of Pharmacological and Physiological Science, Saint Louis University, Saint Louis, MO, USA
    J Neuroendocrinol 25:1290-7. 2013
  2. doi Central neuropeptide W has anorexigenic effect in rats
    T Naso
    Department of Veterinary Anatomy and Histology, Faculty of Agriculture, University of Miyazaki, Miyazaki, Japan
    J Anim Physiol Anim Nutr (Berl) 98:228-34. 2014
  3. doi Neuropeptide B and W regulate leptin and resistin secretion, and stimulate lipolysis in isolated rat adipocytes
    Marek Skrzypski
    Department of Animal Physiology and Biochemistry, Poznan University of Life Sciences, 35 Wołyńska Street, 60 637 Poznan, Poland
    Regul Pept 176:51-6. 2012
  4. doi Neuropeptide W influences the excitability of neurons in the rat hypothalamic arcuate nucleus
    Christopher J Price
    Department of Physiology, Queen s University, Kingston, Ont, Canada
    Neuroendocrinology 88:88-94. 2008
  5. doi Association of neuropeptide W, but not obestatin, with energy intake and endocrine status in Zucker rats. A new player in long-term stress-feeding interactions
    Bernard Beck
    INSERM, U954, Nutrition, Génétique et Expositions aux Risques Environnementaux NUTRIGENEX, Vandoeuvre, France
    Appetite 55:319-24. 2010
  6. doi Neuropeptide W: an anorectic peptide regulated by leptin and metabolic state
    Yukari Date
    Frontier Science Research Center, University of Miyazaki, Kiyotake, Miyazaki, Japan
    Endocrinology 151:2200-10. 2010
  7. doi Distribution of neuropeptide W in the rat brain
    Fumiko Takenoya
    Department of Anatomy, Showa University School of Medicine, 1 5 8 Hatanodai, Shinagawa ku, Tokyo 142 8555, Japan
    Neuropeptides 44:99-106. 2010
  8. ncbi Neuropeptide B (NPB) and neuropeptide W (NPW) system in cultured rat calvarial osteoblast-like (ROB) cells: NPW and NPB inhibit proliferative activity of ROB cells
    Agnieszka Ziolkowska
    Department of Histology and Embryology, Poznan University of Medical Sciences, 60 781 Poznan, Poland
    Int J Mol Med 24:781-7. 2009
  9. pmc Neuropeptide W has cell phenotype-specific effects on the excitability of different subpopulations of paraventricular nucleus neurones
    C J Price
    Department of Physiology, Queen s University, Kingston, Ontario, Canada
    J Neuroendocrinol 21:850-7. 2009
  10. ncbi Identification of neuropeptide W as the endogenous ligand for orphan G-protein-coupled receptors GPR7 and GPR8
    Yukio Shimomura
    Discovery Research Laboratories I and Discovery Research Laboratories II, Pharmaceutical Research Division, Takeda Chemical Industries Limited, 10 Wadai, Tsukuba, Ibaraki 300 4293, Japan
    J Biol Chem 277:35826-32. 2002

Scientific Experts

  • Bernard Beck
  • Yukari Date
  • Fumiko Takenoya
  • Masamitsu Nakazato
  • Seiji Shioda
  • Haruaki Kageyama
  • Marcin Rucinski
  • Mayumi Seki
  • Yukio Shimomura
  • Ludwik K Malendowicz
  • Muhtashan S Mondal
  • Agnieszka Ziolkowska
  • Masaaki Mori
  • T Naso
  • Willis K Samson
  • A T Pate
  • Marek Skrzypski
  • Meghan M Taylor
  • W K Samson
  • Jennifer R Baker
  • Krzysztof W Nowak
  • Naoko Nonaka
  • C J Price
  • Hideki Yamaguchi
  • Katsuya Dezaki
  • Kazuo Itabashi
  • Christopher J Price
  • Alastair V Ferguson
  • Valerie R Jackson
  • S Shousha
  • A El-Kirdasy
  • G L C Yosten
  • Maciej Sassek
  • Przemysław Kaczmarek
  • Mathias Z Strowski
  • Ewa Pruszyńska-Oszmałek
  • Paweł A Kołodziejski
  • Tatiana Wojciechowicz
  • Dawid Szczepankiewicz
  • Kanako Shiba
  • Masoud Ghamari-Langroudi
  • Michiko Yagi
  • Kei Endo
  • Noboru Murakami
  • Roger D Cone
  • A V Ferguson
  • Marianna Tyczewska
  • Ryosuke Matsuno
  • Yuri Kintaka
  • Masami Hirayama
  • Koji Toshinai
  • Takuya Shimbara
  • Shinji Kitamura
  • Tomoko Tsuruta
  • Shuji Inoue
  • Toshihiko Yada
  • Joanna Chmielewska
  • Hans Peter Nothacker
  • Steven H Lin
  • Olivier Civelli
  • Zhiwei Wang
  • Erik A Yuill
  • Catharine C Ferri
  • Cynthia Bober
  • Kara Cardinal
  • Masahiko Fujino
  • Michiko Abe
  • Haruo Onda
  • Mioko Harada
  • Yoshio Matsumoto
  • Chieko Kitada
  • Mika Goto
  • Tsukasa Sugo
  • Taiji Asami
  • Takuya Watanabe

Detail Information

Publications18

  1. pmc Compromise of endogenous neuropeptide W production abrogates the dipsogenic and pressor effects of angiotensin II in adult male rats
    A T Pate
    Department of Pharmacological and Physiological Science, Saint Louis University, Saint Louis, MO, USA
    J Neuroendocrinol 25:1290-7. 2013
    b>Neuropeptide W (NPW), an endogenous ligand for the G-protein coupled receptor GPR7, is produced in neurones in the rat hypothalamus and brain stem known to be important in the control of food intake and the neuroendocrine response to ..
  2. doi Central neuropeptide W has anorexigenic effect in rats
    T Naso
    Department of Veterinary Anatomy and Histology, Faculty of Agriculture, University of Miyazaki, Miyazaki, Japan
    J Anim Physiol Anim Nutr (Berl) 98:228-34. 2014
    b>Neuropeptide W (NPW) is produced in neurons located in hypothalamus, brain stem and antral G cells and its receptors are present in the hypothalamus, in particular in the paraventricular nucleus (PVN)...
  3. doi Neuropeptide B and W regulate leptin and resistin secretion, and stimulate lipolysis in isolated rat adipocytes
    Marek Skrzypski
    Department of Animal Physiology and Biochemistry, Poznan University of Life Sciences, 35 Wołyńska Street, 60 637 Poznan, Poland
    Regul Pept 176:51-6. 2012
    Neuropeptide B (NPB) and W (NPW) regulate food intake and energy homeostasis in humans via two G-protein-coupled receptor subtypes, termed as GPR7 and GPR8. Rodents express GPR7 only...
  4. doi Neuropeptide W influences the excitability of neurons in the rat hypothalamic arcuate nucleus
    Christopher J Price
    Department of Physiology, Queen s University, Kingston, Ont, Canada
    Neuroendocrinology 88:88-94. 2008
    b>Neuropeptide W (NPW) is a ligand of the recently deorphaned receptor GPR7. Intracerebroventricular injection of this peptide results in reduced serum growth hormone concentration...
  5. doi Association of neuropeptide W, but not obestatin, with energy intake and endocrine status in Zucker rats. A new player in long-term stress-feeding interactions
    Bernard Beck
    INSERM, U954, Nutrition, Génétique et Expositions aux Risques Environnementaux NUTRIGENEX, Vandoeuvre, France
    Appetite 55:319-24. 2010
    The aim of this study was to ascertain the roles of neuropeptide W (NPW) and obestatin in feeding and endocrine regulations and their interactions with leptin, corticosterone, and insulin, three key hormones involved in metabolic ..
  6. doi Neuropeptide W: an anorectic peptide regulated by leptin and metabolic state
    Yukari Date
    Frontier Science Research Center, University of Miyazaki, Kiyotake, Miyazaki, Japan
    Endocrinology 151:2200-10. 2010
    b>Neuropeptide W (NPW) is an anorectic peptide produced in the brain...
  7. doi Distribution of neuropeptide W in the rat brain
    Fumiko Takenoya
    Department of Anatomy, Showa University School of Medicine, 1 5 8 Hatanodai, Shinagawa ku, Tokyo 142 8555, Japan
    Neuropeptides 44:99-106. 2010
    b>Neuropeptide W (NPW), which was recently isolated from the porcine hypothalamus, has been identified as the endogenous ligand of the orphan G protein-coupled receptors GPR7 (NPBWR1) and GPR8 (NPBWR2)...
  8. ncbi Neuropeptide B (NPB) and neuropeptide W (NPW) system in cultured rat calvarial osteoblast-like (ROB) cells: NPW and NPB inhibit proliferative activity of ROB cells
    Agnieszka Ziolkowska
    Department of Histology and Embryology, Poznan University of Medical Sciences, 60 781 Poznan, Poland
    Int J Mol Med 24:781-7. 2009
    Neuropeptides B (NPB) and W (NPW) have been identified as endogenous ligands of two G-protein-coupled receptors, neuropeptides B/W receptor 1 (NPBWR1, formerly known as GPR7) and neuropeptides B/W receptor 2 (NPBWR2, formerly known as ..
  9. pmc Neuropeptide W has cell phenotype-specific effects on the excitability of different subpopulations of paraventricular nucleus neurones
    C J Price
    Department of Physiology, Queen s University, Kingston, Ontario, Canada
    J Neuroendocrinol 21:850-7. 2009
    The administration of the neuropeptide W (NPW) and neuropeptide B (NPB) in rodents has been shown to influence the activity of a variety of autonomic and neuroendocrine systems...
  10. ncbi Identification of neuropeptide W as the endogenous ligand for orphan G-protein-coupled receptors GPR7 and GPR8
    Yukio Shimomura
    Discovery Research Laboratories I and Discovery Research Laboratories II, Pharmaceutical Research Division, Takeda Chemical Industries Limited, 10 Wadai, Tsukuba, Ibaraki 300 4293, Japan
    J Biol Chem 277:35826-32. 2002
    ..We designated the two ligands neuropeptide W-23 (NPW23) and neuropeptide W-30 (NPW30)...
  11. ncbi Ontogeny of a new enteric peptide, neuropeptide W (NPW), in the developing rat stomach
    Muhtashan S Mondal
    Division of Neurology, Respirology, Endocrinology, and Metabolism, Department of Internal Medicine, Faculty of Medicine, University of Miyazaki, Kiyotake, Miyazaki 889 1692, Japan
    Regul Pept 145:141-6. 2008
    b>Neuropeptide W (NPW), a novel endogenous peptide for G protein-coupled receptors GPR7 and GPR8, is expressed in the gastric antral mucosa of rat, mouse, and human stomachs...
  12. ncbi Neuronal interactions between neuropeptide W- and orexin- or melanin-concentrating hormone-containing neurons in the rat hypothalamus
    Fumiko Takenoya
    Department of Anatomy, Showa University School of Medicine, 1 5 8 Hatanodai, Shinagawa ku, Tokyo 142 8555, Japan
    Regul Pept 145:159-64. 2008
    b>Neuropeptide W (NPW) was recently discovered as the endogenous ligand for GPR7 and GPR8, which are orphan G protein-coupled receptors isolated from the porcine brain...
  13. ncbi Neuropeptide W is expressed in the noradrenalin-containing cells in the rat adrenal medulla
    Mayumi Seki
    Department of Anatomy, Showa University School of Medicine, 1 5 8 Hatanodai Shinagawa ku, Tokyo 142 8555, Japan
    Regul Pept 145:147-52. 2008
    b>Neuropeptide W (NPW) is an endogenous ligand for GPR7, a member of the G-protein-coupled receptor family...
  14. ncbi Neuropeptide W in the rat pancreas: potentiation of glucose-induced insulin release and Ca2+ influx through L-type Ca2+ channels in beta-cells and localization in islets
    Katsuya Dezaki
    Department of Physiology, Division of Integrative Physiology, Jichi Medical University School of Medicine, Yakushiji 3311 1, Shimotsuke, Tochigi 329 0498, Japan
    Regul Pept 145:153-8. 2008
    b>Neuropeptide W (NPW) is a regulatory peptide that acts via two subtypes of G protein-coupled receptors, GPR7 and GPR8. Evidence has been provided that NPW is involved in the central regulation of energy homeostasis and feeding behavior...
  15. ncbi Neuropeptide W exerts a potent suppressive effect on blood leptin and insulin concentrations in the rat
    Marcin Rucinski
    Department of Histology and Embryology, School of Medicine, Poznan University of Medical Sciences, 60 781 Poznan, Poland
    Int J Mol Med 19:401-5. 2007
    ..The other, neuropeptide W (NPW), has been identified in two molecular forms of 23 and 30 amino acids (NPW23 and NPW30), respectively...
  16. ncbi A study of the rat neuropeptide B/neuropeptide W system using in situ techniques
    Valerie R Jackson
    Department of Developmental and Cell Biology, University of California Irvine, Irvine, California 92697 4625, USA
    J Comp Neurol 497:367-83. 2006
    In the rat, the neuropeptide B/neuropeptide W (NPB/NPW) system is composed of two ligands, neuropeptide B (NPB) and neuropeptide W (NPW), and one receptor, GPR7...
  17. ncbi Actions of neuropeptide W in paraventricular hypothalamus: implications for the control of stress hormone secretion
    Meghan M Taylor
    Pharmacological and Physiological Science, Saint Louis University School of Medicine, 1402 South Grand Blvd, St Louis, MO 63104, USA
    Am J Physiol Regul Integr Comp Physiol 288:R270-5. 2005
    b>Neuropeptide W (NPW) is produced in neurons located in hypothalamus and brain stem, and its receptors are present in the hypothalamus, in particular in the paraventricular nucleus (PVN)...
  18. ncbi Neuropeptide W acts in brain to control prolactin, corticosterone, and growth hormone release
    Jennifer R Baker
    Pharmacological and Physiological Sciences, St Louis University School of Medicine, 1402 South Grand Boulevard, St Louis, MO 63104, USA
    Endocrinology 144:2816-21. 2003
    The endogenous, peptide ligand for the orphan receptors GPR7 and GPR8 was identified to be neuropeptide W (NPW)...