Nos2

Summary

Gene Symbol: Nos2
Description: nitric oxide synthase 2
Alias: Nos2a, iNos, nitric oxide synthase, inducible, NOS type II, inducible NO synthase, inducible NOS, inducible nitric oxide synthase, nitric oxide synthase 2, inducible, macrophage, peptidyl-cysteine S-nitrosylase NOS2
Species: rat

Top Publications

  1. pmc Acute physical exercise reverses S-nitrosation of the insulin receptor, insulin receptor substrate 1 and protein kinase B/Akt in diet-induced obese Wistar rats
    Jose R Pauli
    Departamento de Clinica Medica, FCM UNICAMP, Universidade Estadual de Campinas, Campinas, SP, Brasil
    J Physiol 586:659-71. 2008
  2. pmc Endotoxin mediated-iNOS induction causes insulin resistance via ONOO⁻ induced tyrosine nitration of IRS-1 in skeletal muscle
    Genevieve Pilon
    Department of Medicine, Quebec Heart and Lung Institute Laval Hospital, Ste Foy, Quebec, Canada
    PLoS ONE 5:e15912. 2010
  3. pmc Nucleotide oligomerization domain 1 is a dominant pathway for NOS2 induction in vascular smooth muscle cells: comparison with Toll-like receptor 4 responses in macrophages
    L Moreno
    Cardiothoracic Pharmacology, National Heart and Lung Institute, Imperial College, London, UK
    Br J Pharmacol 160:1997-2007. 2010
  4. doi Functionally important role for arginase 1 in the airway hyperresponsiveness of asthma
    Michelle L North
    Institutes of Medical Sciences, Dalla Lana School of Public Health, Faculty of Medicine, Ontario, Canada
    Am J Physiol Lung Cell Mol Physiol 296:L911-20. 2009
  5. doi Anxiety-like behavior in the elevated-plus maze tests and enhanced IL-1β, IL-6, NADPH oxidase-1, and iNOS mRNAs in the hippocampus during early stage of adjuvant arthritis in rats
    Martina Skurlova
    Department of Normal, Pathological, and Clinical Physiology, Charles University in Prague, 120 00 Prague, Czech Republic
    Neurosci Lett 487:250-4. 2011
  6. doi Blockade of kinin B(1) receptor reverses plasma fatty acids composition changes and body and tissue fat gain in a rat model of insulin resistance
    J P Dias
    Department of Physiology, Faculty of Medicine, Universite de Montreal, Montreal, Quebec, Canada
    Diabetes Obes Metab 14:244-53. 2012
  7. ncbi Hemorrhagic shock-induced vascular hyporeactivity in the rat: relationship to gene expression of nitric oxide synthase, endothelin-1, and select cytokines in corresponding organs
    Liang Ming Liu
    U S Army Institute of Surgical Research, San Antonio, Texas, USA
    J Surg Res 125:128-36. 2005
  8. ncbi Activation of the transcription factor HIF-1 and its target genes, VEGF, HO-1, iNOS, during fracture repair
    D E Komatsu
    Department of Biomedical Engineering, Stony Brook University, NY 11794 2580, USA
    Bone 34:680-8. 2004
  9. ncbi Different roles of nitric oxide synthase-1 and -2 between herpetic and postherpetic allodynia in mice
    A Sasaki
    Department of Applied Pharmacology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, 2630 Sugitani, Toyama 930 0194, Japan
    Neuroscience 150:459-66. 2007
  10. ncbi Chronic inhibition of NOS-2 ameliorates renal injury, as well as COX-2 and TGF-beta 1 overexpression in 5/6 nephrectomized rats
    Pablo Bautista-García
    Department of Nephrology, Instituto Nacional de Cardiologia Ignacio Chavez, Juan Badiano 1, 14080 Mexico City, Mexico
    Nephrol Dial Transplant 21:3074-81. 2006

Research Grants

Detail Information

Publications169 found, 100 shown here

  1. pmc Acute physical exercise reverses S-nitrosation of the insulin receptor, insulin receptor substrate 1 and protein kinase B/Akt in diet-induced obese Wistar rats
    Jose R Pauli
    Departamento de Clinica Medica, FCM UNICAMP, Universidade Estadual de Campinas, Campinas, SP, Brasil
    J Physiol 586:659-71. 2008
    Early evidence demonstrates that exogenous nitric oxide (NO) and the NO produced by inducible nitric oxide synthase (iNOS) can induce insulin resistance...
  2. pmc Endotoxin mediated-iNOS induction causes insulin resistance via ONOO⁻ induced tyrosine nitration of IRS-1 in skeletal muscle
    Genevieve Pilon
    Department of Medicine, Quebec Heart and Lung Institute Laval Hospital, Ste Foy, Quebec, Canada
    PLoS ONE 5:e15912. 2010
    ..Here we examined the role of inducible nitric oxide synthase (iNOS) in skeletal muscle insulin resistance using LPS challenge in rats and mice as in vivo models ..
  3. pmc Nucleotide oligomerization domain 1 is a dominant pathway for NOS2 induction in vascular smooth muscle cells: comparison with Toll-like receptor 4 responses in macrophages
    L Moreno
    Cardiothoracic Pharmacology, National Heart and Lung Institute, Imperial College, London, UK
    Br J Pharmacol 160:1997-2007. 2010
    ..Lipopolysaccharide (LPS) activates TLR4, while peptidoglycan products activate NOD1. Activation of NOD1 by the specific agonist FK565 results in a profound vascular dysfunction and experimental shock in vivo...
  4. doi Functionally important role for arginase 1 in the airway hyperresponsiveness of asthma
    Michelle L North
    Institutes of Medical Sciences, Dalla Lana School of Public Health, Faculty of Medicine, Ontario, Canada
    Am J Physiol Lung Cell Mol Physiol 296:L911-20. 2009
    ..However, ARG2, NOS1, NOS2, and agmatinase were also increased, whereas NOS3 expression was decreased...
  5. doi Anxiety-like behavior in the elevated-plus maze tests and enhanced IL-1β, IL-6, NADPH oxidase-1, and iNOS mRNAs in the hippocampus during early stage of adjuvant arthritis in rats
    Martina Skurlova
    Department of Normal, Pathological, and Clinical Physiology, Charles University in Prague, 120 00 Prague, Czech Republic
    Neurosci Lett 487:250-4. 2011
    ..IL-6), corticotrophin releasing factor (CRH), NADPH oxidases NOX1 and NOX2, and inducible NO-synthase (iNOS). EPM tests showed a higher anxiety index in AA rats on days 2 and 4 and reduction of total entries...
  6. doi Blockade of kinin B(1) receptor reverses plasma fatty acids composition changes and body and tissue fat gain in a rat model of insulin resistance
    J P Dias
    Department of Physiology, Faculty of Medicine, Universite de Montreal, Montreal, Quebec, Canada
    Diabetes Obes Metab 14:244-53. 2012
    ..This study examined the effect of B(1) R blockade on the changes in plasma fatty acids composition, body and tissue fat mass and adipose tissue inflammation that influence insulin resistance...
  7. ncbi Hemorrhagic shock-induced vascular hyporeactivity in the rat: relationship to gene expression of nitric oxide synthase, endothelin-1, and select cytokines in corresponding organs
    Liang Ming Liu
    U S Army Institute of Surgical Research, San Antonio, Texas, USA
    J Surg Res 125:128-36. 2005
    ..To evaluate possible mechanisms involved, the present study investigated the gene expression of iNOS, eNOS, IL-1beta, IL-6, TNF-alpha, and endothelin-1 in the corresponding organs, and the roles of nitric oxide (NO) ..
  8. ncbi Activation of the transcription factor HIF-1 and its target genes, VEGF, HO-1, iNOS, during fracture repair
    D E Komatsu
    Department of Biomedical Engineering, Stony Brook University, NY 11794 2580, USA
    Bone 34:680-8. 2004
    ..the temporal mRNA expression patterns of HIF-1alpha, vascular endothelial growth factor (VEGF), inducible nitric oxide synthase (iNOS), and heme oxygenase-1 (HO-1)...
  9. ncbi Different roles of nitric oxide synthase-1 and -2 between herpetic and postherpetic allodynia in mice
    A Sasaki
    Department of Applied Pharmacology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, 2630 Sugitani, Toyama 930 0194, Japan
    Neuroscience 150:459-66. 2007
    ..The virus inoculation induced NOS2 expression in the lumbar dorsal horn of mice with herpetic allodynia, but not postherpetic allodynia...
  10. ncbi Chronic inhibition of NOS-2 ameliorates renal injury, as well as COX-2 and TGF-beta 1 overexpression in 5/6 nephrectomized rats
    Pablo Bautista-García
    Department of Nephrology, Instituto Nacional de Cardiologia Ignacio Chavez, Juan Badiano 1, 14080 Mexico City, Mexico
    Nephrol Dial Transplant 21:3074-81. 2006
    ..However, the role of inducible nitric oxide synthase (NOS-2) is still controversial...
  11. ncbi Effects of volume depletion and NaHCO3 loading on the expression of Na+/H+ exchanger isoform 3, Na+: HCO3- cotransporter type 1 and nitric oxide synthase in rat kidney
    Seong Kwon Ma
    Chonnam National University Research Institute of Medical Sciences, Gwangju, Korea
    Clin Exp Pharmacol Physiol 35:262-7. 2008
    ..The expression of NHE3, NBC1, nNOS and iNOS proteins was determined in the cortex of the kidney by immunoblotting and immunohistochemistry...
  12. doi Differential expression of pro-inflammatory cytokines, endothelin-1 and nitric oxide synthases in the rat carotid body exposed to intermittent hypoxia
    Rodrigo Del Rio
    Laboratorio de Neurobiologia, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, Alameda 340, Santiago, Chile
    Brain Res 1395:74-85. 2011
    ..we studied the time-course of the changes in the immunohistological expression of TNF-α, IL-1β, IL-6, ET-1, iNOS, eNOS and 3-nitrotyrosine in the CB, along with the progression of enhanced CB chemosensory responses to acute ..
  13. ncbi [Association between pulmonary vascular remodeling and expression of hypoxia-inducible factor-1α, endothelin-1 and inducible nitric oxide synthase in pulmonary vessels in neonatal rats with hypoxic pulmonary hypertension]
    Jian Rong Wang
    Department of Neonatology, First Affiliated Hospital of Xinjiang Medical University, Urumqi, China
    Zhongguo Dang Dai Er Ke Za Zhi 15:138-44. 2013
    ..pulmonary vascular remodeling and expression of hypoxia-inducible factor-1α (HIF-1α), endothelin-1 (ET-1) and inducible nitric oxide synthase (iNOS) in pulmonary vessels in neonatal rats with hypoxic pulmonary hypertension (HPH).
  14. ncbi Role of phosphatidylinositol 3-kinase/Akt pathway in angiotensin II and insulin-like growth factor-1 modulation of nitric oxide synthase in vascular smooth muscle cells
    Esma R Isenovic
    Department of Biochemistry, SUNY Health Science Center, Brooklyn, NY 11203, USA
    Endocrine 19:287-92. 2002
    ..between angiotensin II (Ang II) and insulin-like growth factor-1 (IGF-1) in regulation of inducible nitric oxide synthase (iNOS) in vascular smooth muscle cells (VSMCs)...
  15. ncbi Heme oxygenase-1 attenuates interleukin-1beta-induced nitric oxide synthase expression in vascular smooth muscle cells
    Nian Chung Yang
    Division of Cardiovascular Research, Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan, ROC
    J Biomed Sci 11:799-809. 2004
    ..of HO-1 in the vascular inflammatory response, we examined the effect of HO-1 on the expression of inducible nitric oxide synthase (iNOS) induced by interleukin-1beta (IL-1beta) in rat vascular smooth muscle cells (VSMCs)...
  16. ncbi Insulin-like growth factor 1 prevents liver injury through the inhibition of TNF-alpha and iNOS induction in D-galactosamine and LPS-treated rats
    Takeshi Hijikawa
    The Department of Surgery, Kansai Medical University, Moriguchi, Osaka, Japan
    Shock 29:740-7. 2008
    ..We hypothesized that IGF-1 inhibited the induction of these cytokines and iNOS, resulting in beneficial effect in the liver...
  17. pmc Sonic Hedgehog gene delivery to the rodent heart promotes angiogenesis via iNOS/netrin-1/PKC pathway
    Rafeeq P H Ahmed
    Department of Pathology and Laboratory Medicine, University of Cincinnati, Cincinnati, Ohio, United States of America
    PLoS ONE 5:e8576. 2010
    ..stem cells (MSCs) with Sonic Hedgehog (Shh) transgene, a morphogen during embryonic development and embryonic and adult stem cell growth, improved their survival and angiogenic potential in the ischemic heart via iNOS/netrin/PKC pathway.
  18. ncbi Analysis of pulmonary heme oxygenase-1 and nitric oxide synthase alterations in experimental hepatopulmonary syndrome
    Junlan Zhang
    Department of Internal Medicine, Liver Center, University of Alabama at Birmingham, 1918 University Boulevard, Birmingham, AL 35294 0005, USA
    Gastroenterology 125:1441-51. 2003
    ..Our aim was to explore the role of the heme oxygenase-1/carbon monoxide pathway in the pathogenesis of experimental hepatopulmonary syndrome...
  19. ncbi Expression of nitric oxide synthase, aquaporin 1 and aquaporin 5 in rat after bleomycin inhalation
    An Soo Jang
    Department of Internal Medicine, Soonchunhyang University Hospital, 1174 Jung dong, Wonmi gu, Bucheon si, 420 767 Gyeonggi do, Republic of Korea
    Intensive Care Med 30:489-95. 2004
    ..The aim of this study was to investigate the role of NO synthase (NOS) and AQP in acute lung injury (ALI) lung following bleomycin inhalation in rats...
  20. ncbi Angiotensin II differentially regulates interleukin-1-beta-inducible NO synthase (iNOS) and vascular cell adhesion molecule-1 (VCAM-1) expression: role of p38 MAPK
    Bingbing Jiang
    Whitaker Cardiovascular Institute, Vascular Biology Unit, Department of Medicine, Boston University School of Medicine, Boston, MA 02118, USA
    J Biol Chem 279:20363-8. 2004
    ..of angiotensin II on interleukin-1beta-induced NF-kappaB activation and the subsequent expression of inducible NO synthase (iNOS) and vascular cell adhesion molecule-1 (VCAM-1) in cultured rat vascular smooth muscle cells...
  21. ncbi Up-regulation of IL-1 receptor through PI3K/Akt is essential for the induction of iNOS gene expression in hepatocytes
    Shigeru Teshima
    Department of Surgery, Kansai Medical University, Osaka 570 8506, Japan
    J Hepatol 40:616-23. 2004
    ..DNA binding of NF-kappaB is essential, as interleukin-1beta (IL-1beta) stimulates the induction of inducible nitric oxide synthase (iNOS) gene expression in hepatocytes...
  22. ncbi Heme oxygenase-1 gene expression increases vascular relaxation and decreases inducible nitric oxide synthase in diabetic rats
    M Ahmad
    Department of Physiology, New York Medical College, Valhalla, New York 10595, USA
    Cell Mol Biol (Noisy-le-grand) 51:371-6. 2005
    ..such as glutathione and bilirubin, we investigated whether upregulation of HO-1 modulates the levels of iNOS and eNOS and altered vascular responses to phenylephrine (PE) and acetylcholine (Ach) in aorta and femoral arteries ..
  23. doi Mucin-depleted foci show strong activation of inflammatory markers in 1,2-dimethylhydrazine-induced carcinogenesis and are promoted by the inflammatory agent sodium dextran sulfate
    Angelo Pietro Femia
    Department of Pharmacology, University of Florence, Florence, Italy
    Int J Cancer 125:541-7. 2009
    ..to colon carcinogenesis, therefore, the expression of markers such as cyclooxygenase-2 (COX-2), inducible nitric oxide synthase (i-NOS) and macrophage infiltration was studied with immunohistochemistry (IH) in MDF harvested from ..
  24. ncbi p38 MAPK-mediated transcriptional activation of inducible nitric-oxide synthase in glial cells. Roles of nuclear factors, nuclear factor kappa B, cAMP response element-binding protein, CCAAT/enhancer-binding protein-beta, and activating transcription fact
    Narayan R Bhat
    Department of Neurology, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    J Biol Chem 277:29584-92. 2002
    ..that mitogen-activated protein kinase (MAPK) cascades signal the induction of inducible nitric-oxide synthase (iNOS) in glial cells (Bhat, N. R., Zhang, P., Lee, J. C., and Hogan E. L. (1998) J. Neurosci. 18, 1633-1641; Bhat, N. R...
  25. ncbi Inducible nitric oxide synthase is involved in acid-induced gastric hyperemia in rats and mice
    Mia Phillipson
    Dept of Medical Cell Biology, Uppsala University, PO Box 571, SE 751 23 Uppsala, Sweden
    Am J Physiol Gastrointest Liver Physiol 285:G154-62. 2003
    ..kg-1. h-1 iv, in iNOS-deficient (-/-) and nNOS(-/-) mice...
  26. ncbi Intracellular coexpression of endothelin-1 and inducible nitric oxide synthase underlies hypoperfusion after traumatic brain injury in the rat
    D Rafols
    Department of Anatomy and Cell Biology, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Neurosci Lett 362:154-7. 2004
    ..injury to demonstrate colocalization of mRNAs for endothelin-1 (ET-1, a powerful vasoconstrictor) and inducible nitric oxide synthase (iNOS, generator of NO, a vasodilator) in individual cells that form the brain's microvascular wall...
  27. ncbi 1400W, a potent selective inducible NOS inhibitor, improves histopathological outcome following traumatic brain injury in rats
    M Jafarian-Tehrani
    Laboratoire de Pharmacologie UPRES EA 2510, Universite Rene Descartes, 4, avenue de l Observatoire, 75270 Paris Cedex 06, France
    Nitric Oxide 12:61-9. 2005
    There are conflicting data regarding the role of nitric oxide (NO) produced by inducible NO synthase (iNOS) in the pathophysiology of traumatic brain injury (TBI)...
  28. ncbi Isoflurane induces second window of preconditioning through upregulation of inducible nitric oxide synthase in rat heart
    Mayu Wakeno-Takahashi
    Department of Anesthesiology, Kansai Medical Univ, Moriguchi city 570 8507, Japan
    Am J Physiol Heart Circ Physiol 289:H2585-91. 2005
    ..We tested the hypothesis that isoflurane-induced SWOP is mediated through upregulation of inducible NOS (iNOS). Rats inhaled 0.75 minimum alveolar concentration (MAC) isoflurane, 1.5 MAC isoflurane, or O2 for 2 h...
  29. ncbi Differential induction of PPAR-gamma by luminal glutamine and iNOS by luminal arginine in the rodent postischemic small bowel
    N Sato
    Department of Surgery, Houston School of Medicine, University of Texas, 77030, USA
    Am J Physiol Gastrointest Liver Physiol 290:G616-23. 2006
    Using a rodent model of gut ischemia-reperfusion (I/R), we have previously shown that the induction of inducible nitric oxide synthase (iNOS) is harmful, whereas the induction of heme oxygenase 1 (HO-1) and peroxisome proliferator-..
  30. ncbi Effect of adenovirus-mediated gene transfer of nitric oxide synthase on vascular reactivity of rat isolated pulmonary arteries
    Leifu Jiang
    Department of Pneumology, University Hospital Gasthuisberg, Herestraat 49, 3000 Leuven, Belgium
    Pflugers Arch 452:213-21. 2006
    Aerosol gene transfer of endothelial nitric oxide synthase (eNOS) and inducible NOS (iNOS) to rat lungs increased NOS expression and activity, and prevented hypoxic pulmonary vasoconstriction (HPV) in vivo...
  31. ncbi Site- and cell-type- specific induction of intestinal inducible nitric oxide synthase in a rat model of endotoxemia
    T Takahashi
    Department of Anesthesiology and Resuscitology, Okayama University Graduate School of Medicine and Dentistry, Okayama, 700 8558, Japan
    Med Chem 1:643-7. 2005
    ..The intestine is one of the major organs that are involved in sepsis. The inducible isoform of nitric oxide synthase (iNOS) is known to play a critical role in the pathogenesis of septic tissue injury by generating excess amount of nitric ..
  32. ncbi Inducible nitric oxide synthase and cyclooxygenase-2 participate in anti-inflammatory and analgesic effects of the natural marine compound lemnalol from Formosan soft coral Lemnalia cervicorni
    Yen Hsuan Jean
    Section of Orthopedic Surgery, Pingtung Christian Hospital, 60 Da Lan Road, Pingtung 900, Taiwan
    Eur J Pharmacol 578:323-31. 2008
    ..demonstrate that lemnalol significantly inhibited the expression of the pro-inflammatory proteins, inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2), in LPS-stimulated RAW 264.7 cells...
  33. doi Role of inducible nitric oxide synthase in induction of RhoA expression in hearts from diabetic rats
    Hesham Soliman
    Division of Pharmacology and Toxicology, Faculty of Pharmaceutical Sciences, University of British Columbia, 2146 East Mall, Vancouver, BC, Canada V6T 1Z3
    Cardiovasc Res 79:322-30. 2008
    ..of RhoA expression in vascular smooth muscle, and we have previously found that the expression of inducible NO synthase (iNOS) is increased in hearts from STZ-diabetic rats...
  34. doi Nitric oxide triggers delayed anesthetic preconditioning-induced cardiac protection via activation of nuclear factor-kappaB and upregulation of inducible nitric oxide synthase
    Chen Hsiu Chen
    Department of Anesthesiology, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan, Republic of China
    Shock 30:241-9. 2008
    ..activation of nuclear transcription factor-kappaB (NF-kappaB), leading to myocardial adaptation by upregulation of iNOS and increase in production of NO...
  35. doi Fasting-induced intestinal apoptosis is mediated by inducible nitric oxide synthase and interferon-{gamma} in rat
    Junta Ito
    Josai Univ, 1 1 Keyaki dai, Sakado, Saitama, Japan 350 0295
    Am J Physiol Gastrointest Liver Physiol 298:G916-26. 2010
    ..We performed immunohistochemistry for inducible NO synthase (iNOS) expression in the jejunum and measured tissue nitrite levels using HPLC and 8-hydroxydeoxyguanosine ..
  36. ncbi AP-1 mediates beta-amyloid-induced iNOS expression in PC12 cells via the ERK2 and p38 MAPK signaling pathways
    Jung Hee Jang
    National Research Laboratory, College of Pharmacy, Seoul National University, Seoul 151 742, Republic of Korea
    Biochem Biophys Res Commun 331:1421-8. 2005
    ..Expression of inducible nitric oxide synthase (iNOS) and production of nitric oxide (NO) have been frequently elevated in AD...
  37. ncbi Pulmonary hypertension in human newborns with congenital diaphragmatic hernia is associated with decreased vascular expression of nitric-oxide synthase
    Sherif M K Shehata
    Department of Pharmacology, Sophia Children s Hospital, Erasmus MC, University Medical Center Rotterdam, The Netherlands
    Cell Biochem Biophys 44:147-55. 2006
    ..the expression pattern of NO-generating enzyme nitric-oxide synthase (NOS) (both endothelial [eNOS] and inducible [iNOS] isoforms) in the lungs of CDH patients with PH and evaluated the influence of ECMO on the expression levels of ..
  38. ncbi Nitric oxide signaling via nuclearized endothelial nitric-oxide synthase modulates expression of the immediate early genes iNOS and mPGES-1
    Fernand Gobeil
    Department of Pharmacology, Universite de Sherbrooke, Sherbrooke, Quebec J1H 5N4, Canada
    J Biol Chem 281:16058-67. 2006
    ..acid (LPA) resulted in LPA1 receptor-mediated and nitricoxide-dependent up-regulation of the immediate early genes iNOS (inducible nitric-oxide synthase (NOS)) and mPGES-1 (microsomal prostaglandin E synthase-1)...
  39. doi Reciprocal regulation of iNOS and PARP-1 during allergen-induced eosinophilia
    A S Naura
    Louisiana State University Health Sciences Center, Dept of Pharmacology and Experimental Therapeutics, 1901 Perdido St, New Orleans, LA 70112, USA
    Eur Respir J 33:252-62. 2009
    b>Inducible nitric oxide synthase (iNOS) inhibition was recently shown to exert no effect on allergen challenge in human asthma, raising serious concerns about the role of the protein in the disease...
  40. ncbi Molecular cloning of a cDNA encoding an inducible calmodulin-dependent nitric-oxide synthase from rat liver and its expression in COS 1 cells
    H Adachi
    Biochemistry Division, National Cancer Center Research Institute, Tokyo, Japan
    Eur J Biochem 217:37-43. 1993
    ..Northern-blot analysis showed that the mRNA in the liver is approximately 4.2 kb long and is induced transcriptionally by treatment with P. acnes and lipopolysaccharide...
  41. ncbi Pulmonary expression of iNOS and HO-1 protein is upregulated in a rat model of prehepatic portal hypertension
    R A Schroeder
    Department of Surgery, Georgetown University Medical Center, Washington, DC 20007, USA
    Dig Dis Sci 45:2405-10. 2000
    ..with preserved hepatic function, we examined pulmonary elaboration of endothelial nitric oxide synthase (NOS), inducible NOS, heme oxygenase- 1 (HO-1), heme oxygenase-2 (HO-2), endothelin-1 mRNA, and protein...
  42. ncbi High glucose increases inducible NO production in cultured rat mesangial cells. Possible role in fibronectin production
    Hyunjin Noh
    Division of Nephrology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea
    Nephron 90:78-85. 2002
    ..on the constitutive nitric oxide synthase (cNOS) pathway present in endothelial cells, and the role of the inducible NOS (iNOS) pathway in diabetic nephropathy has remained unclear...
  43. ncbi Inducible nitric oxide synthase, but not xanthine oxidase, is highly expressed in interstitial pneumonias and granulomatous diseases of human lung
    Essi Lakari
    Department of Internal Medicine, University of Oulu and Oulu University Hospital, Finland
    Am J Clin Pathol 117:132-42. 2002
    We assessed the distribution and expression of inducible nitric oxide synthase (i-NOS), endothelial nitric oxide synthase (e-NOS), and xanthine oxidase (XAO) in usual interstitial pneumonia, desquamative interstitial pneumonia, and ..
  44. ncbi Peroxisomal localization of inducible nitric oxide synthase in hepatocytes
    Donna Beer Stolz
    Department of Cell Biology and Physiology, University of Pittsburgh Medical School, Pittsburgh, PA 12561, USA
    Hepatology 36:81-93. 2002
    Shock states induce the expression of inducible nitric oxide synthase (iNOS) in both Kupffer cells and hepatocytes in the liver, but little is known about its subcellular localization in these cells...
  45. ncbi Decreased haem oxygenase-1 and increased inducible nitric oxide synthase in the lung of severe COPD patients
    P Maestrelli
    Dept of Environmental Medicine and Public Health, Section of Respiratory Diseases, University of Padova, Padua, Italy
    Eur Respir J 21:971-6. 2003
    ..study examined the expression of antioxidant and pro-oxidant enzymes, haem oxygenases (HO) and inducible nitric oxide synthase (iNOS) respectively, in patients with severe COPD and control smokers without lung function ..
  46. ncbi Downregulation of nitric oxide synthase in nephrotic syndrome: role of proteinuria
    Zhenmin Ni
    Division of Nephrology and Hypertension, Departments of Medicine, Physiology and Biophysics, University of California, Irvine, CA 92868, USA
    Biochim Biophys Acta 1638:129-37. 2003
    ..Urinary excretion of Na and NO metabolites (NOx), as well as immunodetectable endothelial (eNOS), inducible (iNOS) and neuronal (nNOS) NO synthases were determined in rats with puromycin aminonucleoside (PAN)-induced NS, rats ..
  47. ncbi Enhanced iNOS expression in leukocytes and circulating endothelial cells is associated with the progression of coronary artery lesions in acute Kawasaki disease
    Xianyi Yu
    Department of Pediatrics, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama, Toyama, 930 0194 Japan
    Pediatr Res 55:688-94. 2004
    ..We investigated whether enhanced nitric oxide synthase (iNOS) expression in peripheral blood leukocytes and circulating endothelial cells mirrors the progression of coronary ..
  48. ncbi Hyperhomocysteinemia activates NF-kappaB and inducible nitric oxide synthase in the kidney
    Fan Zhang
    Department of Pharmacology, Faculty of Medicine, University of Hong Kong, Hong Kong, China
    Kidney Int 65:1327-38. 2004
    ..The objective of the present study was to investigate the effect of hyperhomocysteinemia on renal NF-kappaB activation and the consequence of such activation...
  49. ncbi Role of inducible nitric oxide synthase-derived nitric oxide in silica-induced pulmonary inflammation and fibrosis
    Patti Zeidler
    National Institute for Occupational Safety and Health, Health Effects Laboratory Division, and Department of Physiology and Pharmacology, West Virginia University, Morgantown, West Virginia 26505, USA
    J Toxicol Environ Health A 67:1001-26. 2004
    Inhalation of crystalline silica can produce lung inflammation and fibrosis. Inducible nitric oxide synthase (iNOS)-derived nitric oxide (NO) is believed to be involved in silica-induced lung disease...
  50. ncbi Rat gastric injury after lipopolysaccharide: role of inducible nitric oxide synthase
    Emily K Robinson
    Department of Surgery, University of Texas Health Science Center, Houston, TX 77026, USA
    Surgery 138:523-9. 2005
    ..This effect is abrogated by inducible nitric oxide synthase (iNOS) inhibition...
  51. ncbi Reperfusion liver injury induces down-regulation of eNOS and up-regulation of iNOS in lung tissues
    H I Lin
    Department of Medicine, Catholic Cardinal Tien Hospital, Taipei, Taiwan
    Transplant Proc 38:2203-6. 2006
    ..Acute lung injury and inflammation can occur after hepatic ischemia/reperfusion (I/R). Little is known regarding the possible role of nitric oxide synthase expression in this complex type of lung injury...
  52. ncbi Glycochenodeoxycholate (GCDC) inhibits cytokine induced iNOS expression in rat hepatocytes
    Brian T Bucher
    Department of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    J Surg Res 138:15-21. 2007
    ..The purpose of this study was to examine the effect of the bile salt GCDC on the regulation of iNOS expression, a key immune modulator during liver inflammation.
  53. ncbi A novel inhibitor of inducible nitric oxide synthase, ONO-1714, does not ameliorate hypoxia-induced pulmonary hypertension in rats
    Bao Hua Jiang
    Department of Anesthesiology and Critical Care Medicine, Mie University Graduate School of Medicine, 2 174, Edobashi, Tsu, Mie, 514 8507, Japan
    Lung 185:303-8. 2007
    A recent study showed that long-term administration of the inducible nitric oxide synthase (iNOS) inhibitor L-NIL reduced the development of pulmonary hypertension...
  54. doi The effect of selective inhibition of inducible nitric oxide synthase on cytochrome P450 after liver transplantation in a rat model
    E Matevossian
    Department of Surgery, Technical University of Munich, Klinikum rechts der Isar, Munich, Germany
    Transplant Proc 40:983-5. 2008
    ..Some in vitro studies have shown decreased CYP activation of inducible nitric oxide synthase (iNOS) in rejecting liver grafts...
  55. doi Inducible nitric oxide synthase mediates retinal DNA damage in Goto-Kakizaki rat retina
    Izumi Yuasa
    Department of Ophthalmology, Mie University Graduate School of Medicine, Edobashi, Tsu Shi, Mie, Japan
    Jpn J Ophthalmol 52:314-22. 2008
    ..and oxidative DNA damage induced by 8-nitroguanine and 8-hydroxy-2-deoxy guanosine (8-OHdG), and to determine the role played by inducible nitric oxide synthase (iNOS) in damage to DNA in the retina of the Goto-Kakizaki (GK) rat.
  56. doi Involvement of neuronal, inducible and endothelial nitric oxide synthases in capsaicin-induced muscle hypersensitivity
    Jong Seok Lee
    Department of Neural and Pain Sciences, University of Maryland Baltimore, School of Dentistry, Baltimore, MD 21201, USA
    Eur J Pain 13:924-8. 2009
    ..Specifically, we examined the contribution of neuronal, inducible and endothelial nitric oxide synthases, nNOS, iNOS and eNOS, respectively, in mediating masseter hypersensitivity under acute inflammatory condition...
  57. doi S-allylcysteine attenuates renal injury by altering the expressions of iNOS and matrix metallo proteinase-2 during cyclosporine-induced nephrotoxicity in Wistar rats
    Vinayagam Magendiramani
    Department of Biochemistry, University of Madras, Guindy Campus, Chennai 600 025, India
    J Appl Toxicol 29:522-30. 2009
    ..Elevated expressions of inducible nitric oxide synthase (iNOS) and nuclear factor kappa B (NF-kappaB) due to CsA administration were reduced by SAC treatment...
  58. doi iNOS-derived nitric oxide mediates the increase in TFF2 expression associated with gastric damage: role of HIF-1
    Dolores Ortiz-Masia
    Department of Pharmacology, Faculty of Medicine, University of Valencia, Avda Blasco Ibáñez 15 17, Valencia, Spain
    FASEB J 24:136-45. 2010
    ..The aim of the present study was to analyze the role of iNOS-derived NO in HIF-1alpha stabilization and TFF gene expression in damaged gastric mucosa...
  59. ncbi Effect of triterpene acids of Eriobotrya japonica (Thunb.) Lindl. leaf and MAPK signal transduction pathway on inducible nitric oxide synthase expression in alveolar macrophage of chronic bronchitis rats
    Y Huang
    School of Pharmacy, Anhui Medical University, Hefei 230032, Anhui Province, China
    Am J Chin Med 37:1099-111. 2009
    ..Using in vivo test, we found that SB203580, a p38 MAPK inhibitor, (10 muM) significantly inhibited inducible nitric oxide synthase (iNOS) mRNA expression in AM...
  60. doi Peroxisome proliferator-activated receptor-gamma agonists suppress iNOS expression induced by LPS in rat primary Schwann cells
    Fupeng Zhang
    Department of Microbiology and Immunology, Medical College, Nantong 19 Qixiu Road, Nantong, Jiangsu, 226001, China
    J Neuroimmunol 218:36-47. 2010
    ..peripheral nervous system (PNS) inflammation, Schwann cells (SCs) are activated, producing inducible nitric oxide synthase (iNOS), contributed to the pathogenesis of demyelinating disease, such as multiple sclerosis...
  61. doi Lung eNOS and iNOS are reoxygenation time-dependent upregulated after acute hypoxia
    Alma Rus
    Department of Experimental Biology, University of Jaen, Jaen, Spain
    Anat Rec (Hoboken) 293:1089-98. 2010
    ..We measured endothelial and inducible NOS (eNOS, iNOS) mRNA and protein expression, location, and in situ NOS activity as well as nitrated protein ..
  62. doi Upregulation of AT1R and iNOS in the rostral ventrolateral medulla (RVLM) is essential for the sympathetic hyperactivity and hypertension in the 2K-1C Wistar rat model
    Elizabeth Barbosa de Oliveira-Sales
    Cardiovascular Division, Department of Physiology, Federal University of Sao Paulo, Sao Paulo, Brazil
    Am J Hypertens 23:708-15. 2010
    We hypothesized that upregulation of angiotensin type 1 receptor (AT(1)R) and inducible nitric oxide (NO) synthase (iNOS) within the rostral ventrolateral medulla (RVLM) could contribute to two-kidney, one-clip (2K-1C) hypertension.
  63. ncbi [Effects of Chinese herbal medicine Jinmaitong-medicated serum on inducible nitric oxide synthase and NADPH oxidase p22-phox subunit of rat Schwann cells cultured in high-glucose medium]
    Li Zhao
    Department of Traditional Chinese Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing 100730, China
    Zhong Xi Yi Jie He Xue Bao 9:299-305. 2011
    ..of Jinmaitong (JMT), a compound Chinese herbal medicine, on nicotinamide adenine dinucleotide phosphate (NADPH) oxidase p22-phox subunit and inducible nitric oxide synthase (iNOS) of rat Schwann cells cultured in high-glucose medium.
  64. ncbi [Expression of heme oxygenase-1 and inducible nitric oxide synthase in the lungs of hyperoxia-exposed preterm rats]
    Yu Feng Quan
    Department of Neonatology, Affiliated Hospital of Guilin Medical College, Guilin, Guangxi 541001, China
    Zhongguo Dang Dai Er Ke Za Zhi 13:577-80. 2011
    To study the expression and the role of heme oxygenase-1 (HO-1) and inducible nitric oxide synthase (iNOS) in preterm rats with hyperoxia-induced lung injuries.
  65. pmc Role of inducible nitric oxide synthase pathway on methotrexate-induced intestinal mucositis in rodents
    Renata Fc Leitão
    Department of Morphology, Federal University of Ceara, Fortaleza, Brazil
    BMC Gastroenterol 11:90. 2011
    ..Studies have suggested an important role of nitric oxide in such injury. The aim of this study was to investigate the role of nitric oxide (NO), specifically iNOS on the pathogenesis of methotrexate (MTX)-induced intestinal mucositis.
  66. doi Diacerhein improves glucose tolerance and insulin sensitivity in mice on a high-fat diet
    Natália Tobar
    Department of Internal Medicine, State University of Campinas, Campinas, Sao Paulo, Brazil
    Endocrinology 152:4080-93. 2011
    ..and of inflammatory mediators that modulate insulin signaling in a negative manner (IKKβ, JNK, and inducible nitric oxide synthase)...
  67. doi Anti-inflammation effects of corn silk in a rat model of carrageenin-induced pleurisy
    Guang qiang Wang
    Department of Respiratory, The Affiliated Hospital of Medical College Qingdao University, Qingdao, 266003, People s Republic of China
    Inflammation 35:822-7. 2012
    ..interleukin-17 (IL-17), C3 and C4 complement protein levels, adhesion molecule (ICAM-1) and inducible nitric oxide synthase (iNOS) levels, nuclear factor kappa B (NF-κB) activation, and total antioxidant activity were ..
  68. doi Thrombin induces inducible nitric oxide synthase expression via the MAPK, MSK1, and NF-κB signaling pathways in alveolar macrophages
    Chen Chun Lin
    Department of Chest Medicine, Shin Kong Wu Ho Su Memorial Hospital, Taipei, Taiwan
    Eur J Pharmacol 672:180-7. 2011
    ..protein kinase 1 (MSK1), and nuclear factor-κB (NF-κB) signaling pathways in thrombin-induced inducible nitric oxide synthase (iNOS) expression in alveolar macrophages (NR8383)...
  69. doi Involvement of nitric oxide in mesenteric vascular reactivity following intraperitoneal pancreatic juice in rats
    Chao Fuh Chen
    Department of Internal Medicine, Cheng Hsin General Hospital, Taiwan, Republic of China
    Chin J Physiol 54:419-26. 2011
    The purposes of this study were to examine the protein expressions of endothelial and inducible nitric oxide synthase (eNOS and iNOS) of the rat intestinal smooth muscle, and to elucidate the role of nitric oxide (NO) in the reactivity ..
  70. ncbi Changes in inducible NO synthase in the pial arteries of different diameters in hypertensive rats
    V M Chertok
    Department of Human Anatomy, Vladivostok State Medical University, Russia
    Bull Exp Biol Med 152:258-61. 2011
    ..Immunocytochemical studies of the vessels showed hyperexpression of inducible NO synthase in these deformations...
  71. ncbi [The different roles of the spinal protein nNOS and iNOS in morphine naloxone-precipitated withdrawal response]
    Hai Lin Liu
    Department of Anesthesiology, 1st Affiliated Hospital of Nanjing Medical University, Nanjing, China
    Zhongguo Ying Yong Sheng Li Xue Za Zhi 28:249-53. 2012
    ..intrathecal injection of neuronal nitric oxide synthase (nNOS) inhibitors 7-Nitroindazole (7-Ni) and inducible nitric oxide synthase(iNOS) inhibitors aminoguanidine (AG) on the behavioral changes of morphine-induced dependent and ..
  72. pmc Impairment of nitric oxide synthase but not heme oxygenase accounts for baroreflex dysfunction caused by chronic nicotine in female rats
    Mohamed A Fouda
    Department of Pharmacology and Toxicology, Faculty of Pharmacy, Alexandria University, Alexandria, Egypt
    PLoS ONE 9:e98681. 2014
    ..Thus, the inhibition of NOS, but not HO, accounts for the baroreflex depressant of chronic nicotine. Further, hemin alleviates the nicotine effect through a mechanism that is NOS/sGC but not CO or bilirubin-dependent. ..
  73. pmc Conventional, but not remote ischemic preconditioning, reduces iNOS transcription in liver ischemia/reperfusion
    Bergthor Bjornsson
    Bergthor Björnsson, Anders Winbladh, Per Gullstrand, Per Sandström, Department of Surgery, County Council of Ostergotland, 581 85 Linkoping, Sweden
    World J Gastroenterol 20:9506-12. 2014
    To study the effects of preconditioning on inducible nitric oxide synthase (iNOS) and interleukin 1 (IL-1) receptor transcription in rat liver ischemia/reperfusion injury (IRI).
  74. doi Induction of inducible nitric oxide synthase expression in ammonia-exposed cultured astrocytes is coupled to increased arginine transport by upregulated y(+)LAT2 transporter
    Magdalena Zielinska
    Department of Neurotoxicology, Mossakowski Medical Research Centre, Polish Academy of Sciences, Warsaw, Poland
    J Neurochem 135:1272-81. 2015
    ..Up-regulation of y(+)LAT2 transporter is coupled with increased inducible nitric oxide synthase (iNOS) expression, which leads to increase nitric oxide (NO) synthesis and protein nitration.
  75. doi Effect of Combined Stress on Morphological Changes and Expression of NO Synthases in Rat Ventral Hippocampus
    A V Smirnov
    Volgograd State Medical University, Ministry of Health of the Russian Federation, Volgograd, Russia
    Bull Exp Biol Med 160:96-9. 2015
    ..the microcirculatory bed, perivascular edema, pronounced degenerative changes, and enhanced expression of inducible NO synthase in CA3 pyramidal neurons in the ventral hippocampus of stressed 12-month-old rats were observed...
  76. ncbi Low-dose radiotherapy (LD-RT) and the modulation of iNOS expression in adjuvant-induced arthritis in rats
    G Hildebrandt
    Department of Radiotherapy and Radiooncology, University of Leipzig, Stephanstrasse 9a, D 04103 Leipzig, Germany
    Int J Radiat Biol 79:993-1001. 2003
    ..composition of the inflammatory infiltrate and the expression of the pro-inflammatory and anti-inflammatory enzymes, inducible nitric oxide synthase (iNOS), cyclo-oxygenase 2 (COX-2) and haem-oxygenase 1 (HO-1), in response to LD-RT.
  77. ncbi Effect of NOS inhibition on rat gastric matrix metalloproteinase production during endotoxemia
    Emily K Robinson
    Department of Surgery, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA
    Shock 25:507-14. 2006
    ..As LPS-induced gastric injury is mediated in part by iNOS, and NO modulates MMP production in vitro, we hypothesized that NOS inhibition would similarly modulate LPS-induced ..
  78. ncbi Time-related changes in constitutive and inducible nitric oxide synthases in the rat striatum in a model of Huntington's disease
    Penelope Aguilera
    Laboratorio de Patología Vascular Cerebral, Instituto Nacional de Neurologia y Neurocirugia Manuel Velasco Suarez, Mexico, DF 14269, Mexico
    Neurotoxicology 28:1200-7. 2007
    ..on the role of NOS isoforms in QUIN toxicity, we performed real time RT-PCR and immunohistochemistry of inducible NOS (iNOS), endothelial NOS (eNOS) and neuronal NOS (nNOS) and determined Ca(2+)-dependent and Ca(2+)-independent ..
  79. ncbi HO-1 overexpression attenuates endotoxin effects on CAT-2 isozymes expression
    Te Yang Huang
    Department of Orthopedics, Mackay Memorial Hospital, Taipei, Taiwan
    J Surg Res 148:172-80. 2008
    ..transporter (CAT-2) isozymes is one crucial mechanism that regulates nitric oxide (NO) production via inducible nitric oxide synthase (iNOS)...
  80. doi 1,25-Dihydroxyvitamin D3 prevented allergic asthma in a rat model by suppressing the expression of inducible nitric oxide synthase
    Yan Zhou
    Department of Respiratory Medicine, Shanghai First Hospital, Shanghai Jiao Tong University, Shanghai 200080, China
    Allergy Asthma Proc 29:258-67. 2008
    ..Nitric oxide production and the expression and activity of induced nitric oxide synthase (iNOS) in the lungs were examined also. Our study showed that 1,25(OH)2D3 reduced the airway inflammatory response in BAL...
  81. doi Catalpol attenuates nitric oxide increase via ERK signaling pathways induced by rotenone in mesencephalic neurons
    Jing Bi
    Dalian University of Technology, Liaoning, China
    Neurochem Int 54:264-70. 2009
    ..The current study examined that whether catalpol modulated NO and iNOS increase by rotenone in primary mesencephalic neurons and investigated its underlying signaling pathways...
  82. doi A microarray study of gene expression profiles in nasal polyps
    Beata Rostkowska-Nadolska
    Department of Otolaryngology, Wroclaw Medical University, Poland
    Auris Nasus Larynx 38:58-64. 2011
    ..We studied mRNA gene expression profiles in NP compared with normal mucosa as well as pointed at genes characteristic of different expression in examined tissues...
  83. doi Active hexose-correlated compound and Bifidobacterium longum BB536 exert symbiotic effects in experimental colitis
    Borja Ocón
    Department of Pharmacology, CIBERehd, School of Pharmacy, University of Granada, Granada, Spain
    Eur J Nutr 52:457-66. 2013
    ..The purpose of the present study was to evaluate the possibility of synergism between AHCC, which is believed to act as a prebiotic, and B. longum BB536...
  84. doi Multiple organ inflammatory response to portosystemic shunt in the rat
    Cruz Garcia
    Biochemistry and Molecular Biology Department, School of Medicine, Complutense University of Madrid, Madrid, Spain
    Cytokine 56:680-7. 2011
    ..by ELISA techniques, the expression of the endothelial constitutive nitric oxide synthase (eNOS), inducible nitric oxide synthase (iNOS), constitutive and inducible heme-oxygenase (HO-1 and HO-2) were assayed by Western-blot...
  85. doi Mangiferin decreases inflammation and oxidative damage in rat brain after stress
    Lucía Márquez
    Department of Pharmacology, Faculty of Medicine, Complutense University, Madrid, Spain
    Eur J Nutr 51:729-39. 2012
    ..with antioxidant and anti-inflammatory properties in different experimental settings. In this study, the capacity of MAG to prevent neuroinflammation and brain oxidative damage induced by stress exposure was investigated...
  86. ncbi Puerarin decreases apoptosis of retinal pigment epithelial cells in diabetic rats by reducing peroxynitrite level and iNOS expression
    Li Na Hao
    Ophthalmology Department of Hebei Province People s Hospital, Shijiazhuang, China
    Sheng Li Xue Bao 64:199-206. 2012
    ..were used for determining the expression of nitrotyrosine (NT, the foot print of peroxynitrite), cell apoptosis, iNOS mRNA and Fas/Fas ligand (FasL) signal transduction in RPE cells, respectively...
  87. pmc Insulin inhibits hepatocyte iNOS expression induced by cytokines by an Akt-dependent mechanism
    Brian G Harbrecht
    Department of Surgery and Price Institute for Surgical Research, University of Louisville School of Medicine, Louisville, Kentucky 40292, USA
    Am J Physiol Gastrointest Liver Physiol 302:G116-22. 2012
    Hepatocyte inducible nitric oxide synthese (iNOS) expression is a tightly controlled pathway that mediates hepatic inflammation and hepatocyte injury in a variety of disease states...
  88. ncbi Contribution of nitric oxide to the pathogenesis of cirrhotic cardiomyopathy in bile duct-ligated rats
    H Liu
    Liver Unit, Gastroenterology Research Group, University of Calgary, Calgary, Alberta, Canada
    Gastroenterology 118:937-44. 2000
    ..We aimed to test the role of nitric oxide (NO), a negative inotropic agent, in the pathogenesis of cirrhotic cardiomyopathy in a rat model...
  89. ncbi Inducible nitric oxide synthase plays a role in LPS-induced hyperglycemia and insulin resistance
    Hiroki Sugita
    Department of Anesthesia and Critical Care, Harvard Medical School, Boston, Massachusetts 02114, USA
    Am J Physiol Endocrinol Metab 282:E386-94. 2002
    ..Endotoxin or lipopolysaccharide (LPS) injection is a potent stimulator of inducible nitric oxide synthase (iNOS)...
  90. ncbi Regulation of Sertoli cell tight junction dynamics in the rat testis via the nitric oxide synthase/soluble guanylate cyclase/3',5'-cyclic guanosine monophosphate/protein kinase G signaling pathway: an in vitro study
    Nikki P Y Lee
    Population Council, Center for Biomedical Research, 1230 York Avenue, New York, NY 10021, USA
    Endocrinology 144:3114-29. 2003
    ..Although inducible NOS (iNOS) and endothelial NOS (eNOS) are found in the testis and have been implicated in the regulation of ..
  91. pmc Expression of inducible nitric oxide synthase and cyclooxygenase-2 in pancreatic adenocarcinoma: correlation with microvessel density
    Hans U Kasper
    Department of Pathology, University of Cologne, Joseph Stelzmann Strasse 9, D 50931 Koeln, Germany
    World J Gastroenterol 10:1918-22. 2004
    ..Both have constitutive and inducible isoforms. The inducible isoforms (iNOS and COX-2) are of great interest as regulators of tumor angiogenesis, tumorigenesis and inflammatory processes...
  92. ncbi Importance of cytokines, nitric oxide, and apoptosis in the pathological process of necrotizing pancreatitis in rats
    László Leindler
    Department of Surgery, Hungarian Academy of Sciences, Budapest, Hungary
    Pancreas 29:157-61. 2004
    ..our study was to determine the production of cytokines, tumor necrosis factor (TNF) and interleukin-6 (IL-6), the activation of the inducible nitric oxide synthase (iNOS), and the development of apoptosis during this pathologic process.
  93. ncbi Induction of inducible nitric oxide synthase in hepatocytes isolated from rats with ischemia-reperfusion injury
    H Yanagida
    Department of Surgery, Kansai Medical University, Osaka, Japan
    Transplant Proc 36:1962-4. 2004
    ..However, little is known about how I/R influences the gene expression of inducible nitric oxide synthase (iNOS) in hepatocytes...
  94. ncbi Retinoic acid inhibits expression of TNF-alpha and iNOS in activated rat microglia
    S Thameem Dheen
    Department of Anatomy, Molecular Neurobiology Laboratory, Faculty of Medicine, National University of Singapore, Singapore
    Glia 50:21-31. 2005
    ..actions in various cell types, we have examined its effects on the expression of TNF-alpha and inducible nitric oxide synthase (iNOS) in microglia activated by beta-amyloid peptide (Abeta) and lipopolysaccharide (LPS)...
  95. pmc Temporal expression of hepatic inducible nitric oxide synthase in liver cirrhosis
    Chang Li Wei
    Department of Biochemistry, Faculty of Medicine, National University of Singapore, 119260, Singapore
    World J Gastroenterol 11:362-7. 2005
    Nitric oxide (NO) has been implicated in the pathogenesis of liver cirrhosis. We have found inducible nitric oxide synthase (iNOS) can be induced in hepatocytes of cirrhotic liver...
  96. pmc Weaning induces NOS-2 expression through NF-kappaB modulation in the lactating mammary gland: importance of GSH
    Rosa Zaragoza
    Departamento de Bioquimica y Biologia Molecular, Facultad de Medicina, Universidad de Valencia, Avda Blasco Ibanez 17, 46010 Valencia, Spain
    Biochem J 391:581-8. 2005
    ..we have demonstrated, using chromatin immunoprecipitation assays, binding of NF-kappaB to the NOS-2 (inducible nitric oxide synthase) promoter at the early onset of events triggered during weaning...
  97. ncbi Beta-amyloid-dependent expression of NOS2 in neurons: prevention by an alpha2-adrenergic antagonist
    Sergey Kalinin
    Department of Anesthesiology, University of Illinois, Chicago, 60612, USA
    Antioxid Redox Signal 8:873-83. 2006
    ..antiinflammatory effects on glial cells including suppression of the inducible form of nitric oxide synthase (NOS2)...
  98. ncbi Hypoxia/reoxygenation differentially modulates NF-kappaB activation and iNOS expression in astrocytes and microglia
    Guiwen Guo
    Department of Neurology, Medical University of South Carolina, Charleston, 29425, USA
    Antioxid Redox Signal 8:911-8. 2006
    ..responses of the two glial cell types (astrocytes and microglia) in relation to the expression of inducible nitric oxide synthase (iNOS)...
  99. pmc NO synthase 2 (NOS2) deletion promotes multiple pathologies in a mouse model of Alzheimer's disease
    C A Colton
    Division of Neurology, and Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA
    Proc Natl Acad Sci U S A 103:12867-72. 2006
    ....
  100. ncbi Production of nitric oxide by airways neutrophils in the initial phase of murine asthma
    Patricia Dias Fernandes
    Department of Pharmacology, Institute of Biomedical Sciences, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil
    Int Immunopharmacol 7:96-102. 2007
    ..Moreover, the peak expression of inducible nitric oxide synthase (NOS2), in BALF cells and lung homogenates, was coincident with the peak of BALF neutrophil influx...
  101. ncbi Nitric oxide increases in the rat retina after continuous illumination
    L Piehl
    Cátedra de Física, Facultad de Farmacia y Bioquimica, UBA Lanais RLBM, Argentina
    Brain Res 1156:112-9. 2007
    ..Western blot analysis showed the expression of iNOS in the illuminated retinas with a peak after 24 h of CI, but did not show significant differences of nNOS among ..

Research Grants11

  1. CYTOKINE DYSFUNCTION AND LUNG 5LO METABOLISM IN AIDS
    Michael Coffey; Fiscal Year: 2002
    ..This proposal will further enhance our ability to correct this defect and help boost AM, PBM, and PMN defenses against opportunistic infections in the lung in HIV disease. ..
  2. MYOCYTE RESPONSES DURING EXPERIMENTAL MYASTHENIA GRAVIS
    Keith Krolick; Fiscal Year: 2002
    ..abstract_text> ..
  3. Regulation of Microglial Activation
    Carol Colton; Fiscal Year: 2003
    ..Our preliminary data demonstrate that regulating the level of substrate for iNOS by altering the cellular uptake of arginine via CAT transporters is one such point...
  4. MAP KINASE REGULATION OF MICROGLIAL ACTIVATION
    Narayan Bhat; Fiscal Year: 2004
    ..e., MHC class 11, B7 and CD40), cytokines (i.e., TNFa, IL-1, IL-6) and inducible nitric oxide synthase (iNOS) will be determined by immunochemical and RT-PCR techniques...
  5. MAP KINASES IN OLIGODENDROCYTE CELL SIGNALING
    Narayan Bhat; Fiscal Year: 2005
    ..Putative MAPK-responsive elements and relevant binding activities will be determined by deletion and gel shift analyses ..
  6. Role of Nitirc Oxide in Experimental Myasthenia Gravis
    Keith Krolick; Fiscal Year: 2006
    ..The general strategy to be used in this investigation is to seek links between iNOS/NO production and EAMG by monitoring skeletal muscle following in vivo exposures to immune mediators of EAMG (i.e...
  7. Regulation of neuronal NO by apolipoprotein E
    Carol Colton; Fiscal Year: 2006
    ....
  8. Matrix Metalloproteinases in Gastric Injury
    Emily Robinson; Fiscal Year: 2008
    ..These facilities as well as close guidance and supervision from her sponsor will ensure success of the proposed project. [unreadable] [unreadable]..
  9. Immune Responsiveness, APOE/Gender in Neurodegeneration
    Carol Colton; Fiscal Year: 2008
    ..Thus, we will examine the role of hormones in the regulation of microglial and peritoneal macrophage immune activation in mice expressing only human apoE3 protein or expressing only human apoE4 protein. ..
  10. Neuroinflammation in Cholesterol-Induced AD Pathogenesis
    Narayan Bhat; Fiscal Year: 2009
    ..The outcome of these studies should have implications for developing novel and effective anti- inflammatory treatments for AD. ..
  11. Post-Operative Adhesions: Roles of Hypoxia in Nitric Oxide
    Ghassan Saed; Fiscal Year: 2009
    ..The central hypothesis is that hypoxia modulates inducible nitric oxide synthase (iNOS), further resulting in reduced production of NO, which contributes to pro-inflammatory ..