Nod2

Summary

Gene Symbol: Nod2
Description: nucleotide-binding oligomerization domain containing 2
Alias: Card15, nucleotide-binding oligomerization domain-containing protein 2, caspase recruitment domain family, member 15
Species: rat

Top Publications

  1. ncbi Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease
    J P Hugot
    Fondation Jean Dausset CEPH, 27 rue J Dodu 75010 Paris, France
    Nature 411:599-603. 2001
  2. ncbi CARD15 mutations in Blau syndrome
    C Miceli-Richard
    Fondation Jean Dausset CEPH, Paris, France
    Nat Genet 29:19-20. 2001
  3. pmc Nod1 and Nod2 regulation of inflammation in the Salmonella colitis model
    Kaoru Geddes
    Department of Immunology, University of Toronto, Toronto, Ontario M6G 2T6, Canada
    Infect Immun 78:5107-15. 2010
  4. doi The pattern recognition receptors Nod1 and Nod2 account for neutrophil recruitment to the lungs of mice infected with Legionella pneumophila
    Mariana S Frutuoso
    Department of Cell Biology, University of Sao Paulo, School of Medicine of Ribeirao Preto, FMRP USP, Ribeirao Preto, SP 14049 900, Brazil
    Microbes Infect 12:819-27. 2010
  5. pmc Induction and rescue of Nod2-dependent Th1-driven granulomatous inflammation of the ileum
    Amlan Biswas
    Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 107:14739-44. 2010
  6. doi Contribution of NOD2 to lung inflammation during Staphylococcus aureus-induced pneumonia
    Ronan Kapetanovic
    Institut Pasteur, Unité Cytokines and Inflammation, Département Infection et Epidémiologie, 28 rue du Dr Roux, F 75015 Paris, France
    Microbes Infect 12:759-67. 2010
  7. ncbi Nucleotide-binding oligomerization domain proteins are innate immune receptors for internalized Streptococcus pneumoniae
    Bastian Opitz
    Department of Internal Medicine Infectious Diseases, Charite University Medicine Berlin, 1 Augustenburger Platz, 13353 Berlin, Germany
    J Biol Chem 279:36426-32. 2004
  8. doi Nod2-Rip2 Signaling Contributes to Intestinal Injury Induced by Muramyl Dipeptide Via Oligopeptide Transporter in Rats
    Guoguang Ma
    Department of General Intensive Care Unit, Songjiang Hospital Affiliated to First People s Hospital, Shanghai Jiao Tong University, NO 746, Zhongshan Road, Shanghai, 201600, China
    Dig Dis Sci 60:3264-70. 2015
  9. pmc Nucleotide-binding oligomerization domain-2 inhibits toll-like receptor-4 signaling in the intestinal epithelium
    Ward M Richardson
    Division of Pediatric Surgery, Department of Surgery, Children s Hospital of Pittsburgh and University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Gastroenterology 139:904-17, 917.e1-6. 2010
  10. ncbi Both donor and recipient NOD2/CARD15 mutations associate with transplant-related mortality and GvHD following allogeneic stem cell transplantation
    Ernst Holler
    Division of Hematology Oncology, University Hospital of Regensburg, Germany
    Blood 104:889-94. 2004

Research Grants

  1. Investigation of Nod2: Implications for Uveitis
    Holly Rosenzweig; Fiscal Year: 2008

Scientific Experts

Detail Information

Publications58

  1. ncbi Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease
    J P Hugot
    Fondation Jean Dausset CEPH, 27 rue J Dodu 75010 Paris, France
    Nature 411:599-603. 2001
    ..to identify three independent associations for Crohn's disease: a frameshift variant and two missense variants of NOD2, encoding a member of the Apaf-1/Ced-4 superfamily of apoptosis regulators that is expressed in monocytes...
  2. ncbi CARD15 mutations in Blau syndrome
    C Miceli-Richard
    Fondation Jean Dausset CEPH, Paris, France
    Nat Genet 29:19-20. 2001
    We have identified three missense mutations in the nucleotide-binding domain (NBD) of CARD15/NOD2 in four French and German families with Blau syndrome...
  3. pmc Nod1 and Nod2 regulation of inflammation in the Salmonella colitis model
    Kaoru Geddes
    Department of Immunology, University of Toronto, Toronto, Ontario M6G 2T6, Canada
    Infect Immun 78:5107-15. 2010
    The pattern recognition molecules Nod1 and Nod2 play important roles in intestinal homeostasis; however, how these proteins impact on the development of inflammation during bacterial colitis has not been examined...
  4. doi The pattern recognition receptors Nod1 and Nod2 account for neutrophil recruitment to the lungs of mice infected with Legionella pneumophila
    Mariana S Frutuoso
    Department of Cell Biology, University of Sao Paulo, School of Medicine of Ribeirao Preto, FMRP USP, Ribeirao Preto, SP 14049 900, Brazil
    Microbes Infect 12:819-27. 2010
    ..By using mice deficient for Nod1, Nod2, and Rip2, we found that these receptors accounted for NE recruitment to the lungs of infected mice...
  5. pmc Induction and rescue of Nod2-dependent Th1-driven granulomatous inflammation of the ileum
    Amlan Biswas
    Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 107:14739-44. 2010
    Mutations in the NOD2 gene are strong genetic risk factors for ileal Crohn's disease. However, the mechanism by which these mutations predispose to intestinal inflammation remains a subject of controversy...
  6. doi Contribution of NOD2 to lung inflammation during Staphylococcus aureus-induced pneumonia
    Ronan Kapetanovic
    Institut Pasteur, Unité Cytokines and Inflammation, Département Infection et Epidémiologie, 28 rue du Dr Roux, F 75015 Paris, France
    Microbes Infect 12:759-67. 2010
    ..In this work, we investigated the role of NOD2 in S. aureus-induced pneumonia. We found that the absence of NOD2 affected weight loss and recovery speed...
  7. ncbi Nucleotide-binding oligomerization domain proteins are innate immune receptors for internalized Streptococcus pneumoniae
    Bastian Opitz
    Department of Internal Medicine Infectious Diseases, Charite University Medicine Berlin, 1 Augustenburger Platz, 13353 Berlin, Germany
    J Biol Chem 279:36426-32. 2004
    ..recognition receptors, the cytosolic proteins nucleotide-binding oligomerization domain 1 (Nod1)/CARD4 and Nod2/CARD15, have been found to detect cell wall peptidoglycans...
  8. doi Nod2-Rip2 Signaling Contributes to Intestinal Injury Induced by Muramyl Dipeptide Via Oligopeptide Transporter in Rats
    Guoguang Ma
    Department of General Intensive Care Unit, Songjiang Hospital Affiliated to First People s Hospital, Shanghai Jiao Tong University, NO 746, Zhongshan Road, Shanghai, 201600, China
    Dig Dis Sci 60:3264-70. 2015
    ..Our aim was to investigate the mechanism of the small intestine injury induced by bacterial oligopeptide product muramyl dipeptide (MDP) which is transported by PepT1...
  9. pmc Nucleotide-binding oligomerization domain-2 inhibits toll-like receptor-4 signaling in the intestinal epithelium
    Ward M Richardson
    Division of Pediatric Surgery, Department of Surgery, Children s Hospital of Pittsburgh and University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Gastroenterology 139:904-17, 917.e1-6. 2010
    ..Nucleotide-binding oligomerization domain-2 (NOD2) is an immune receptor that regulates other branches of the immune system, although its effects on TLR4 in ..
  10. ncbi Both donor and recipient NOD2/CARD15 mutations associate with transplant-related mortality and GvHD following allogeneic stem cell transplantation
    Ernst Holler
    Division of Hematology Oncology, University Hospital of Regensburg, Germany
    Blood 104:889-94. 2004
    Single nucleotide polymorphisms (SNPs) of the NOD2/CARD15 gene resulting in a diminished nuclear factor-kappaB (NF-kappaB) response to bacterial cell wall products have been associated with an increased incidence of Crohn disease...
  11. ncbi A new CARD15 mutation in Blau syndrome
    Marjan M van Duist
    Department of Clinical and Biological Sciences, Division of Medical Genetics, University of Torino, Orbassano, Italy
    Eur J Hum Genet 13:742-7. 2005
    The caspase recruitment domain gene CARD15/NOD2, encoding a cellular receptor involved in an NF-kappaB-mediated pathway of innate immunity, was first identified as a major susceptibility gene for Crohn's disease (CD), and more recently, ..
  12. doi Effects of ghrelin on pulmonary NOD2 mRNA expression and NF-κB activation when protects against acute lung injury in rats challenged with cecal ligation and puncture
    Zhiyou Peng
    Department of Anesthesiology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, PR China
    Int Immunopharmacol 13:440-5. 2012
    ..However, our knowledge of ghrelin's effects on the upstream activators of the NF-κB pathway, such as NOD2, is still limited...
  13. pmc NOD2-associated pediatric granulomatous arthritis, an expanding phenotype: study of an international registry and a national cohort in Spain
    Carlos D Rose
    Thomas Jefferson University, Philadelphia, Pennsylvania, USA
    Arthritis Rheum 60:1797-803. 2009
    To study the phenotype characteristics of the largest to date cohort of patients with pediatric granulomatous arthritis (PGA) and documented mutations in the NOD2 gene.
  14. pmc Single nucleotide polymorphisms in pathogen recognition receptor genes are associated with susceptibility to meningococcal meningitis in a pediatric cohort
    Gijs Th J van Well
    Department of Pediatric Infectious Diseases, Immunology and Rheumatology, VU University Medical Center, Amsterdam, The Netherlands
    PLoS ONE 8:e64252. 2013
    ..2*10(-5), OR  = 9.4, 95% CI  = 3.0-29.2). The NOD2 SNP8 mutant was significantly more frequent in MM patients compared to controls (p = 0.0004, OR  = 12...
  15. doi [Effect mechanism of NOD like receptor signaling pathway on intestinal mucosal barrier of rat during early phase of acute intra-abdominal infection]
    Yuan ting Xiao
    Department of General Surgery, Tianjin Tianhe Hospital, Tianjin 300050, China Corresponding author Wang Xi mo, Department of General Surgery, Tianjin Union Medical Center, Colorectal and Anal Disease Institute, Tianjin 300121, China, Email
    Zhonghua Wei Zhong Bing Ji Jiu Yi Xue 25:527-32. 2013
    ..To initially investigate the expressing regularity and effect of enterocyte NOD like receptors on gut mucosal barrier during early phase of acute intra-abdominal infection...
  16. pmc Pivotal role of NOD2 in inflammatory processes affecting atherosclerosis and periodontal bone loss
    Huaiping Yuan
    Center for Anti Inflammatory Therapeutics, School of Dental Medicine and Department of Pharmacology, School of Medicine, Boston University, Boston, MA 02118
    Proc Natl Acad Sci U S A 110:E5059-68. 2013
    ..purpose of this study was to elucidate the role of nucleotide binding oligomerization domain-containing protein 2 (NOD2) signaling in atherosclerosis and periodontal bone loss using an Apolipoprotein E(-/-) (ApoE(-/-)) mouse model ..
  17. pmc Analysis of nucleotide-binding oligomerization domain proteins in a murine model of pneumococcal meningitis
    Xinjie Liu
    Department of Pediatrics, Qilu Hospital, Shandong University, No 107 Wen Hua Xi Road, Jinan, People s Republic of China
    BMC Infect Dis 14:648. 2014
    ....
  18. doi NOD1 and NOD2 Interact with the Phagosome Cargo in Mast Cells: A Detailed Morphological Evidence
    Giuliano Zabucchi
    Department of Life Science, University of Trieste, Via Alfonso Valerio 28 edificio R, Trieste, 34127, Italy
    Inflammation 38:1113-25. 2015
    ..RPMC express NOD1 and NOD2 proteins whose role is to recognize intracellular foreign components and induce the production of pro-inflammatory ..
  19. pmc Characterization of TLR2, NOD2, and related cytokines in mammary glands infected by Staphylococcus aureus in a rat model
    Heng Wang
    College of Veterinary Medicine, Yangzhou University, Yangzhou, Jiangsu, 225009, China
    Acta Vet Scand 57:25. 2015
    ..Local innate immune defenses play an important role in eliminating the invading bacteria. TLR2 and NOD2 are important pathogen recognition receptors, but their functions have not been investigated in the context of ..
  20. ncbi [The expression of NOD1 and NOD2 and the regulation of glucocorticoids on them in allergic rhinitis]
    Shuang Hu
    Department of Otolaryngology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China
    Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 27:393-6. 2013
    To investigate the expression of NOD1 and NOD2 in the nasal mucosa of healthy individuals and allergic rhinitis(AR), and explored the regulation of glucocorticoids on them.
  21. doi Role of the NOD2 genotype in the clinical phenotype of Blau syndrome and early-onset sarcoidosis
    Ikuo Okafuji
    Department of Pediatrics, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Arthritis Rheum 60:242-50. 2009
    ..This systemic inflammatory granulomatosis is associated with mutations in the NOD2 gene...
  22. pmc Association of a NOD2 gene polymorphism and T-helper 17 cells with presumed ocular toxoplasmosis
    Míriam S Dutra
    Centro de Pesquisas Rene Rachou, CPqRR Fundação Oswaldo Cruz, FIOCRUZ, Belo Horizonte, Brazil
    J Infect Dis 207:152-63. 2013
    ..and 89 parent/case trios of presumed ocular toxoplasmosis (POT) to evaluate associations with polymorphisms in the NOD2 gene. Three haplotype-tagging single-nucleotide polymorphisms (tag-SNPs) within the NOD2 gene were genotyped...
  23. doi Low prevalence of NOD2 SNPs in Behçet's disease suggests protective association in Caucasians
    Jasper H Kappen
    Department of Internal Medicine, Section of Clinical Immunology, Erasmus University Hospital, Rotterdam, The Netherlands
    Rheumatology (Oxford) 48:1375-7. 2009
    It has been shown previously that three nucleotide-binding oligomerization domain containing 2 (NOD2) variants (Arg702Trp, Gly908Arg and Lue1007fs) are associated with Crohn's disease (CD), a disorder clinically resembling Behçet's ..
  24. doi Identification of NOD2 as a novel target of RNA-binding protein HuR: evidence from NADPH oxidase-mediated HuR signaling in diabetic nephropathy
    Jin Shang
    Department of Pharmacology, Shandong University School of Medicine, Jinan 250012, China
    Free Radic Biol Med 79:217-27. 2015
    Although our recent studies have demonstrated that NOD2 is one of the critical components of a signal transduction pathway that links renal injury to inflammation in diabetic nephropathy (DN), the regulatory mechanisms for NOD2 expression ..
  25. doi Common variants in NOD2 and IL23R are not associated with inflammatory bowel disease in Indians
    Swapna Mahurkar
    Centre for Cellular and Molecular Biology, Hyderabad, India
    J Gastroenterol Hepatol 26:694-9. 2011
    ..Genome-wide association studies have confirmed the role of nucleotide-binding oligomerization domain protein-2 (NOD2) variants and identified several other genes associated with IBD...
  26. pmc Viral infection augments Nod1/2 signaling to potentiate lethality associated with secondary bacterial infections
    Yun Gi Kim
    Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Cell Host Microbe 9:496-507. 2011
    ..show that the TLR3/MDA5 agonist poly I:C or viral infection dramatically augments signaling via the NLRs Nod1 and Nod2 and enhances the production of proinflammatory cytokines...
  27. pmc Expression of TLR-2, TLR-4, NOD2 and pNF-kappaB in a neonatal rat model of necrotizing enterocolitis
    Aurelie Le Mandat Schultz
    Assistance Publique Hôpitaux de Paris Hôpital R Debré, Service de Chirurgie Pediatrique, Paris, France
    PLoS ONE 2:e1102. 2007
    ..Pattern recognition molecules could be an important player in the initiation of an exaggerated inflammatory response leading to intestinal injury in NEC...
  28. doi Association between NOD2/CARD15 polymorphisms and coronary artery disease: a case-control study
    Sara Galluzzo
    Department of Medical Oncology, Campus Bio Medico University of Rome, Rome, Italy
    Hum Immunol 72:636-40. 2011
    ..In this prospective study we tested the hypothesis of whether polymorphic variations in the NOD2/CARD15 gene may influence the risk of developing clinically evident coronary artery disease (CAD)...
  29. pmc Down-regulated NOD2 by immunosuppressants in peripheral blood cells in patients with SLE reduces the muramyl dipeptide-induced IL-10 production
    Shui Lian Yu
    Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, China
    PLoS ONE 6:e23855. 2011
    ..Pattern recognition receptors (PRRs) such as Toll-like receptors are aberrantly expressed of peripheral blood mononuclear cells (PBMCs) in systemic lupus erythematosus (SLE) patients, for playing immunopathological roles...
  30. doi Anti-inflammatory capacity of selected lactobacilli in experimental colitis is driven by NOD2-mediated recognition of a specific peptidoglycan-derived muropeptide
    Elise Macho Fernandez
    Bactéries Lactiques et Immunité des Muqueuses, Centre d Infection et d Immunité de Lille, Institut Pasteur de Lille, 1 rue du Pr Calmette, 59019 Lille Cedex, France
    Gut 60:1050-9. 2011
    ..Therapeutic use of probiotics is known to be strain specific, but precise mechanisms remain unclear. The role of NOD2 signalling and the protective effect of Lactobacillus peptidoglycan (PGN) and derived muropeptides in experimental ..
  31. doi A NOD2 gene polymorphism is associated with the prevalence and severity of chronic obstructive pulmonary disease in a Japanese population
    Daisuke Kinose
    Department of Respiratory Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    Respirology 17:164-71. 2012
    ..We hypothesized that polymorphisms in the nucleotide-binding and oligomerization domain (NOD)1 and NOD2 genes would be associated with the pathogenesis of COPD...
  32. doi Importance of NOD2/CARD15 gene variants for susceptibility to and outcome of sepsis in Turkish children
    Deniz Tekin
    Institute of Forensic Sciences, Ankara University, Ankara, Turkey
    Pediatr Crit Care Med 13:e73-7. 2012
    ..The role of mutations within the innate immunity receptor NOD2/CARD15 has recently been demonstrated as a risk factor for bacteremia and mortality in adult patients with sepsis...
  33. pmc Deep resequencing of GWAS loci identifies independent rare variants associated with inflammatory bowel disease
    Manuel A Rivas
    Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, Massachusetts, USA
    Nat Genet 43:1066-73. 2011
    ..ulcerative colitis cases and 17,575 healthy controls), we identified four additional independent risk factors in NOD2, two additional protective variants in IL23R, a highly significant association with a protective splice variant in ..
  34. pmc Dectin-1 and NOD2 mediate cathepsin activation in zymosan-induced arthritis in mice
    Holly L Rosenzweig
    Oregon Health and Science University, Mail stop L467 AD, 3181 SW Sam Jackson Park Rd, Portland, OR 97239, USA
    Inflamm Res 60:705-14. 2011
    Activation of pattern recognition receptors (PRR) may contribute to arthritis. Here, we elucidated the role of NOD2, a genetic cause of inflammatory arthritis, and several other PRR in a murine model of inflammatory arthritis.
  35. pmc Nod2 suppresses Borrelia burgdorferi mediated murine Lyme arthritis and carditis through the induction of tolerance
    Tanja Petnicki-Ocwieja
    Division of Geographic Medicine and Infectious Diseases, Tufts Medical Center, Boston, Massachusetts, United States of America
    PLoS ONE 6:e17414. 2011
    ..The intracellular, cytosolic receptor Nod2 has been shown to play varying roles in either enhancing or attenuating inflammation in response to different ..
  36. pmc NOD2 deficiency results in increased susceptibility to peptidoglycan-induced uveitis in mice
    Holly L Rosenzweig
    Casey Eye Institute, Oregon Health and Science University, Portland, Oregon, USA
    Invest Ophthalmol Vis Sci 52:4106-12. 2011
    The innate immune receptor NOD2 is a genetic cause of uveitis (Blau syndrome)...
  37. doi Comprehensive study of baicalin down-regulating NOD2 receptor expression of neurons with oxygen-glucose deprivation in vitro and cerebral ischemia-reperfusion in vivo
    Huiying Li
    Protein Science Laboratory of the Ministry of Education, Laboratory of Pharmaceutical Sciences, School of Life Sciences and School of Medicine, Tsinghua University, Beijing 100084, China
    Eur J Pharmacol 649:92-9. 2010
    ..b>NOD2 (nucleotide-binding oligomerization domain protein 2) is one of the receptors involved in innate immune response ..
  38. doi CARD15/NOD2 polymorphisms are associated with severe pulmonary sarcoidosis
    H Sato
    Clinical Genomics Group Royal Brompton Hospital and NHLI, Imperial College, 1B Manresa Road, London SW3 6LR, UK
    Eur Respir J 35:324-30. 2010
    ..This study explored associations between CARD15 polymorphisms, CCR5 haplotype and distinct pulmonary sarcoidosis subtypes...
  39. ncbi Association of CARD15 polymorphisms with atopy-related traits in a population-based cohort of Caucasian adults
    S Weidinger
    Department of Dermatology and Allergy Biederstein, Technical University Munich, Germany
    Clin Exp Allergy 35:866-72. 2005
    ..Caspase-recruitment domain containing protein 15 (CARD15) is a cytosolic receptor involved in bacterial recognition by antigen-presenting cells...
  40. ncbi TLR and NOD2 ligands induce cell proliferation in the rat intact spinal cord
    Yanhua Su
    Institute of Brain Research, University of Tuebingen, Germany
    J Neuropathol Exp Neurol 64:991-7. 2005
    ..by 5-bromo-2'-deoxyuridine (BrdU) tracing, the effects of peripheral administration of toll-like receptor (TLR) and NOD2 ligands (stimulators of the innate immune system) on the proliferation of spinal cord cells...
  41. ncbi Prevalence of the NOD2 3020insC mutation in aggregations of breast and lung cancer
    Marcin Radosław Lener
    International Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland
    Breast Cancer Res Treat 95:141-5. 2006
    ..of disease, two sets of consecutively collected tumor groups were examined for the 3020insC mutation in the NOD2/CARD15 gene...
  42. ncbi Differential pattern recognition receptor expression but stereotyped responsiveness in rat spleen dendritic cell subsets
    Francois Xavier Hubert
    INSERM Unite 643, Institut de Transplantation et de Recherche en Transplantation ITERT, Centre Hospitalo Universitaire Nantes, Hotel Dieu, 30 Boulevard Jean Monnet, 44093 Nantes Cedex 1, France
    J Immunol 177:1007-16. 2006
    ..We correlated the expression of TLR and nucleotide-binding oligomerization domain 2 (NOD2) in these DC subsets to their in vitro responsiveness to specific ligands...
  43. ncbi Identification of Card15/Nod2 mRNA in intestinal tissue of experimentally induced colitis in rats
    Masahiko Fujisawa
    Department of Veterinary Pharmacology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Japan
    J Vet Med Sci 68:701-8. 2006
    b>Card15/Nod2 has been suggested to be an intracellular pathogen-associated molecular pattern (PAMPs) recognition molecule, which contains a leucine-rich repeat region similar to the Toll-like receptors (TLRs)...
  44. ncbi Combinations of TLR and NOD2 ligands stimulate rat microglial P2X4R expression
    Liang Hao Guo
    Institute of Brain Research, University of Tuebingen, Calwer Str 3, D 72076 Tuebingen, Germany
    Biochem Biophys Res Commun 349:1156-62. 2006
    ..to stimulation by combination of toll-like receptors (TLRs) and nucleotide-binding oligomerization domain 2 (NOD2) receptors. Various TLR1-9 ligands and NOD2 agonist muramyldipeptide (MDP) were investigated...
  45. ncbi Recipient NOD2/CARD15 variants: a novel independent risk factor for the development of bronchiolitis obliterans after allogeneic stem cell transplantation
    Gerhard C Hildebrandt
    Department of Hematology and Oncology, University of Regensburg Medical School, Regensburg, Germany
    Biol Blood Marrow Transplant 14:67-74. 2008
    ..We hypothesized that single nucleotide polymorphisms (SNPs) of the NOD2/CARD15 gene (=NOD2/CARD15 variants) contribute to changes in host defense and subsequent alloreaction, leading to BO...
  46. doi Common nonsynonymous polymorphisms in the NOD2 gene are associated with resistance or susceptibility to tuberculosis disease in African Americans
    Celest M Austin
    Department of Pathology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Infect Dis 197:1713-6. 2008
    Pattern-recognition receptors (PRRs) play a key role in innate immunity against intracellular bacteria. NOD2 is one of the PRRs that contribute to the immune response to Mycobacterium tuberculosis infection...
  47. pmc The NOD/RIP2 pathway is essential for host defenses against Chlamydophila pneumoniae lung infection
    Kenichi Shimada
    Division of Pediatrics, Infectious Diseases, and Immunology, Cedars Sinai Medical Center, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA
    PLoS Pathog 5:e1000379. 2009
    ..Both Nod1(-/-) and Nod2(-/-) mice also showed delayed bacterial clearance, suggesting that C...
  48. doi NOD2 receptors in adenopituitary folliculostellate cells: expression and function
    Eliane Correa-de-Santana
    Department of Endocrinology, Max Planck Institute of Psychiatry, Kraepelinstrasse 2 10, 80804 Munich, Germany
    J Endocrinol 203:111-22. 2009
    ..The NOD2 agonist muramyl dipeptide (MDP) increased Nf kappa b1-transcriptional activity, -protein expression and IL6 ..
  49. doi Total parenteral-nutrition-mediated dendritic-cell activation and infiltration into the small intestine in a rat model
    Satoshi Hagiwara
    Department of Anesthesiology and Intensive Care Medicine, Oita University Faculty of Medicine, 1 1 Idaigaoka Hasamamachi, Yufu, Oita 879 5593, Japan
    J Anesth 25:57-64. 2011
    ..However, effects of TPN on the immune system, including dendritic cells (DC), are not well understood. The purpose of this study was to determine whether TPN affects DC activation and infiltration into the intestinal barrier...
  50. doi Dendritic cell activation in response to ischemia-reperfusion injury of the small intestine
    Satoshi Hagiwara
    Department of Anesthesiology and Intensive Care Medicine, Oita University Faculty of Medicine, 1 1 Idaigaoka Hasamamachi, Yufu, Oita, Japan
    Surg Today 40:137-45. 2010
    ..The aim of this study was to determine whether I/R injury affects DC infiltration into the intestinal barrier...
  51. pmc The 3020insC Allele of NOD2 Predisposes to Cancers of Multiple Organs
    Jan Lubinski
    Pomeranian Medical University, Szczecin, Poland
    Hered Cancer Clin Pract 3:59-63. 2005
    The NOD2 gene has been associated with susceptibility to Crohn's disease and individuals with Crohn's disease are at increased risk for cancer at a number of organ sites...
  52. doi Association of c.802C>T polymorphism of NOD2/CARD15 gene with the chronic gastritis and predisposition to cancer in H. pylori infected patients
    Andrzej Hnatyszyn
    Department of Internal Medicine, District Hospital, Drawsko Pomorskie, Poland
    Exp Mol Pathol 88:388-93. 2010
    This paper shows analysis of the association of the 802C>T polymorphism of the NOD2/CARD15 gene with the occurrence of the chronic inflammation of the gastric mucosa associated with the Helicobacter pylori infections, development of ..
  53. pmc Common polymorphisms in the NOD2 gene region are associated with leprosy and its reactive states
    William Richard Berrington
    Dept of Medicine, University of Washington School of Medicine, 1959 NE Pacific St, Box 356523, Seattle, WA 98195, USA
    J Infect Dis 201:1422-35. 2010
    ..We hypothesized that polymorphisms in the nucleotide-binding oligomerization domain containing 2 (NOD2) gene, for a cytosolic receptor known to detect mycobacteria, are associated with susceptibility to leprosy and its ..
  54. doi Expression of NOD2 in a rat model of acute pancreatitis
    Mingping Qian
    Department of General Surgery, Shanghai 10th People s Hospital, Tongji University School of Medicine, Shanghai, China
    Pancreas 39:1034-40. 2010
    To observe the expression of nucleotide-binding oligomerization domain 2 (NOD2) in rats with acute pancreatitis (AP).
  55. pmc NOD2 polymorphisms in clinical phenotypes of common variable immunodeficiency disorders
    K Packwood
    Department of Immunology, Oxford Radcliffe Hospitals, Oxford, UK
    Clin Exp Immunol 161:536-41. 2010
    ..b>NOD2 acts a microbial sensor and is involved in proinflammatory signalling...
  56. ncbi Association between polymorphisms in caspase recruitment domain containing protein 15 and allergy in two German populations
    Michael Kabesch
    University Children s Hospital, Ludwig Maximilians University Munich, Munchen, Germany
    J Allergy Clin Immunol 111:813-7. 2003
    ..Recently, polymorphisms in caspase recruitment domain containing protein 15 (CARD15), an intracellular LPS receptor protein, have been associated with Crohn's disease...
  57. doi NOD2 activation induces muscle cell-autonomous innate immune responses and insulin resistance
    Akhilesh K Tamrakar
    Program in Cell Biology, The Hospital for Sick Children, Toronto, Ontario, Canada
    Endocrinology 151:5624-37. 2010
    ..the cytosolic pattern recognition receptors nucleotide-binding oligomerization domain-containing protein (NOD)1 and NOD2 are expressed in immune and metabolic tissues and hypothesize that their activation in muscle cells would result in ..
  58. pmc Innate signals from Nod2 block respiratory tolerance and program T(H)2-driven allergic inflammation
    Wei Duan
    Division of Molecular Immunology, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA
    J Allergy Clin Immunol 126:1284-93.e10. 2010
    ..Airway tolerance is critical for protecting the lung from inflammatory disease driven by allergens. However, factors that disrupt tolerance processes and then lead to susceptibility to developing allergic asthma remain elusive...

Research Grants1

  1. Investigation of Nod2: Implications for Uveitis
    Holly Rosenzweig; Fiscal Year: 2008
    The underlying mechanisms of uveitis remain poorly understood. However, a recently identified gene called Nod2, provides important insight into the genetics involved in the pathogenesis of uveitis...