Nkx2 2

Summary

Gene Symbol: Nkx2 2
Description: NK2 homeobox 2
Alias: homeobox protein Nkx-2.2, NK2 transcription factor related, locus 2
Species: rat

Top Publications

  1. pmc Pdx-1 or Pdx-1-VP16 protein transduction induces beta-cell gene expression in liver-stem WB cells
    Juliette Cuvelier Delisle
    UMR 707 IECM ENVN, F 44307 Nantes, France
    BMC Res Notes 2:3. 2009
  2. doi Ectopic transgenic expression of NKX2.2 induces differentiation of adult pancreatic progenitors and mediates islet regeneration
    Shuyuan Chen
    Baylor Research Institute, Dallas, TX, USA
    Cell Cycle 11:1544-53. 2012
  3. ncbi Induction of insulin production in rat pancreatic acinar carcinoma cells by conophylline
    K Umezawa
    Faculty of Science and Technology, Department of Applied Chemistry, Keio University, 3 14 1 Hiyoshi, Kohoku Ku, Yokohama 223 0061, Japan
    Biomed Pharmacother 57:341-50. 2003
  4. ncbi Transient upregulation of Nkx2.2 expression in oligodendrocyte lineage cells during remyelination
    Masahiko Watanabe
    Department of Physiology and Neurobiology, University of Connecticut, Storrs, Connecticut 06269, USA
    Glia 46:311-22. 2004
  5. ncbi Increased expression of Nkx2.2 and Olig2 identifies reactive oligodendrocyte progenitor cells responding to demyelination in the adult CNS
    Stephen P J Fancy
    Cambridge Centre for Brain Repair and Centre for Veterinary Sciences, University of Cambridge, Cambridge CB3 0ES, United Kingdom
    Mol Cell Neurosci 27:247-54. 2004
  6. ncbi Stage-specific expression of myelin basic protein in oligodendrocytes involves Nkx2.2-mediated repression that is relieved by the Sp1 transcription factor
    Qiou Wei
    Division of Basic Biomedical Sciences, University of South Dakota School of Medicine, Vermillion, South Dakota 57069, USA
    J Biol Chem 280:16284-94. 2005
  7. pmc Endogenous Nkx2.2+/Olig2+ oligodendrocyte precursor cells fail to remyelinate the demyelinated adult rat spinal cord in the absence of astrocytes
    Jason F Talbott
    The MD PhD Program, University of Louisville, Louisville, KY 40292, USA
    Exp Neurol 192:11-24. 2005
  8. ncbi Nkx2.2 expression in differentiation of oligodendrocyte precursor cells and inhibitory factors for differentiation of oligodendrocytes after traumatic spinal cord injury
    Kaori Suyama
    Department of Orthopaedic Surgery, Surgical Science, Tokai University School of Medicine, Kanagawa, Japan
    J Neurotrauma 24:1013-25. 2007
  9. doi In vitro transformation of adult rat hepatic progenitor cells into pancreatic endocrine hormone-producing cells
    Hiroyuki Kawasaki
    First Department of Surgery, Sapporo Medical University School of Medicine, S 1, W 16, Chuo Ku, Sapporo, Hokkaido 060 8543, Japan
    J Hepatobiliary Pancreat Surg 15:310-7. 2008
  10. doi Effects of progesterone on oligodendrocyte progenitors, oligodendrocyte transcription factors, and myelin proteins following spinal cord injury
    Florencia Labombarda
    Laboratory of Neuroendocrine Biochemistry, Instituto de Biologia y Medicina Experimental, CONICET, Buenos Aires, Argentina
    Glia 57:884-97. 2009

Scientific Experts

  • Juliette Cuvelier Delisle
  • K Umezawa
  • Vanessa Louzier
  • Masahiko Watanabe
  • Shuyuan Chen
  • Tao Wang
  • Florencia Labombarda
  • Hiroyuki Kawasaki
  • Kaori Suyama
  • Jason F Talbott
  • Qiou Wei
  • Stephen P J Fancy
  • Shinichi Matsumoto
  • Paul A Grayburn
  • Jiaxi Chen
  • Masayuki Shimoda
  • Bin Zhang
  • Guodong Yang
  • Libo Yao
  • Shaoping Ji
  • Lintao Jia
  • Michael Schumacher
  • Paulina Roig
  • Alejandro F De Nicola
  • Rachida Guennoun
  • Analia Lima
  • Susana L Gonzalez
  • Yasushi Sasaki
  • Takashi Tokino
  • Koichi Hirata
  • Yamato Kikkawa
  • Tadashi Katsuramaki
  • Yasuo Kokai
  • Toshihiro Mitaka
  • Hideki Oshima
  • Jun ichi Miyazaki
  • Toru Mizuguchi
  • Masaaki Imai
  • Daisuke Sakai
  • Takahiro Osada
  • Joji Mochida
  • W Keith Miskimins
  • Robin Miskimins
  • Mary Bartlett Bunge
  • Ying Liu
  • Scott R Whittemore
  • Mengsheng S Qiu
  • David N Loy
  • Mahendra S Rao
  • Robin J M Franklin
  • Tarik Hadzic
  • Akiko Nishiyama
  • Chao Zhao

Detail Information

Publications11

  1. pmc Pdx-1 or Pdx-1-VP16 protein transduction induces beta-cell gene expression in liver-stem WB cells
    Juliette Cuvelier Delisle
    UMR 707 IECM ENVN, F 44307 Nantes, France
    BMC Res Notes 2:3. 2009
    ..Pdx-1 has the ability to permeate different cell types due to an inherent protein transduction domain (PTD). In this study, we evaluated liver-to-pancreas conversion of WB cells following Pdx-1 or Pdx-1-VP16 protein transduction...
  2. doi Ectopic transgenic expression of NKX2.2 induces differentiation of adult pancreatic progenitors and mediates islet regeneration
    Shuyuan Chen
    Baylor Research Institute, Dallas, TX, USA
    Cell Cycle 11:1544-53. 2012
    ..Nkx2.2 targeted to the pancreas by UTMD induces pancreatic progenitor cell proliferation and differentiation with subsequent islet regeneration and cure of STZ-induced diabetes for three months...
  3. ncbi Induction of insulin production in rat pancreatic acinar carcinoma cells by conophylline
    K Umezawa
    Faculty of Science and Technology, Department of Applied Chemistry, Keio University, 3 14 1 Hiyoshi, Kohoku Ku, Yokohama 223 0061, Japan
    Biomed Pharmacother 57:341-50. 2003
    ....
  4. ncbi Transient upregulation of Nkx2.2 expression in oligodendrocyte lineage cells during remyelination
    Masahiko Watanabe
    Department of Physiology and Neurobiology, University of Connecticut, Storrs, Connecticut 06269, USA
    Glia 46:311-22. 2004
    ..2 gene, which may trigger the existing NG2-expressing precursors in the adult CNS to undergo terminal differentiation into remyelinating OLs...
  5. ncbi Increased expression of Nkx2.2 and Olig2 identifies reactive oligodendrocyte progenitor cells responding to demyelination in the adult CNS
    Stephen P J Fancy
    Cambridge Centre for Brain Repair and Centre for Veterinary Sciences, University of Cambridge, Cambridge CB3 0ES, United Kingdom
    Mol Cell Neurosci 27:247-54. 2004
    ..2 and Olig2 plays a critically important role in the differentiation of adult OPCs into remyelinating oligodendrocytes and that these genes may present novel targets for therapeutic manipulation in cases where remyelination is impaired...
  6. ncbi Stage-specific expression of myelin basic protein in oligodendrocytes involves Nkx2.2-mediated repression that is relieved by the Sp1 transcription factor
    Qiou Wei
    Division of Basic Biomedical Sciences, University of South Dakota School of Medicine, Vermillion, South Dakota 57069, USA
    J Biol Chem 280:16284-94. 2005
    ..2 in preventing the precocious expression of myelin basic protein in immature oligodendrocytes. Based on this study and our previous reports, a model for myelin basic protein gene control is proposed...
  7. pmc Endogenous Nkx2.2+/Olig2+ oligodendrocyte precursor cells fail to remyelinate the demyelinated adult rat spinal cord in the absence of astrocytes
    Jason F Talbott
    The MD PhD Program, University of Louisville, Louisville, KY 40292, USA
    Exp Neurol 192:11-24. 2005
    ..In vivo electrophysiology demonstrated a limited and unsustained functional recovery concurrent with endogenous remyelination following EB-induced lesions...
  8. ncbi Nkx2.2 expression in differentiation of oligodendrocyte precursor cells and inhibitory factors for differentiation of oligodendrocytes after traumatic spinal cord injury
    Kaori Suyama
    Department of Orthopaedic Surgery, Surgical Science, Tokai University School of Medicine, Kanagawa, Japan
    J Neurotrauma 24:1013-25. 2007
    ..These results suggest that environmental factors such as cytokines may affect Nkx2.2 expression or oligodendrocyte precursor cell differentiation in the contusion-induced spinal cord injury model...
  9. doi In vitro transformation of adult rat hepatic progenitor cells into pancreatic endocrine hormone-producing cells
    Hiroyuki Kawasaki
    First Department of Surgery, Sapporo Medical University School of Medicine, S 1, W 16, Chuo Ku, Sapporo, Hokkaido 060 8543, Japan
    J Hepatobiliary Pancreat Surg 15:310-7. 2008
    ..Our goal in this study was to see if small hepatocytes (SHs) could give rise to pancreatic endocrine cells via exogenous Pdx-1 gene expression...
  10. doi Effects of progesterone on oligodendrocyte progenitors, oligodendrocyte transcription factors, and myelin proteins following spinal cord injury
    Florencia Labombarda
    Laboratory of Neuroendocrine Biochemistry, Instituto de Biologia y Medicina Experimental, CONICET, Buenos Aires, Argentina
    Glia 57:884-97. 2009
    ..Thus, progesterone effects on oligodendrogenesis and myelin proteins may constitute fundamental steps for repairing traumatic injury inflicted to the spinal cord...
  11. doi Identification of Juxtanodin promoter and its transcriptional regulation during the ATRA-induced differentiation of C6 cells
    Tao Wang
    Department of Biochemistry and Molecular Biology, The Fourth Military Medical University, Xi an, People s Republic of China
    Mol Cell Biochem 350:177-83. 2011
    ..In summary, our study here suggests that Nkx2.2 is one of the essential transcription factors delivering the specificity of JN promoter in oligodendrocytes...