Ngf

Summary

Gene Symbol: Ngf
Description: nerve growth factor
Alias: Ngfb, beta-NGF, beta-nerve growth factor, nerve growth factor (beta polypeptide)
Species: rat

Top Publications

  1. pmc Production and characterization of biologically active recombinant beta nerve growth factor
    F Hallbook
    Department of Medical Genetics, Uppsala University, Sweden
    Mol Cell Biol 8:452-6. 1988
  2. pmc NGF and BDNF signaling control amyloidogenic route and Abeta production in hippocampal neurons
    Carmela Matrone
    Institute of Neurobiology and Molecular Medicine, Consiglio Nazionale delle Ricerche, Via del Fosso di Fiorano 64, 00143 Rome, Italy
    Proc Natl Acad Sci U S A 105:13139-44. 2008
  3. pmc Paraplegia increased cardiac NGF content, sympathetic tonus, and the susceptibility to ischemia-induced ventricular tachycardia in conscious rats
    Heidi L Lujan
    Department of Physiology, Wayne State Univ School of Medicine, 540 E Canfield Ave, Detroit, MI 48201, USA
    Am J Physiol Heart Circ Physiol 296:H1364-72. 2009
  4. pmc The role of enhanced cutaneous IL-1beta signaling in a rat tibia fracture model of complex regional pain syndrome
    Wen Wu Li
    Physical Medicine and Rehabilitation Service, Veterans Affairs Palo Alto Health Care System, Palo Alto, CA 94304, USA
    Pain 144:303-13. 2009
  5. pmc Endogenous nerve growth factor regulates collagen expression and bladder hypertrophy through Akt and MAPK pathways during cystitis
    Chul Won Chung
    Department of Physiology and Biophysics, Virginia Commonwealth University School of Medicine, Richmond, Virginia 23298 0551, USA
    J Biol Chem 285:4206-12. 2010
  6. pmc Global expression analysis identified a preferentially nerve growth factor-induced transcriptional program regulated by sustained mitogen-activated protein kinase/extracellular signal-regulated kinase (ERK) and AP-1 protein activation during PC12 cell dif
    Steven Mullenbrock
    Department of Biology, Boston University, Boston, Massachusetts 02215, USA
    J Biol Chem 286:45131-45. 2011
  7. ncbi Nerve growth factor-mediated increases in protein methylation occur predominantly at type I arginine methylation sites and involve protein arginine methyltransferase 1
    Thomas R Cimato
    Department of Pharmacology and Toxicology, University at Buffalo School of Medicine and Biomedical Sciences, State University of New York, 3435 Main Street, Buffalo, NY 14214 3000, USA
    J Neurosci Res 67:435-42. 2002
  8. pmc Selective inhibition of extracellular signal-regulated kinases 1/2 blocks nerve growth factor to brain-derived neurotrophic factor signaling and suppresses the development of and reverses already established pain behavior in rats
    Y Matsuoka
    Department of Anesthesiology, University of Wisconsin School of Medicine and Public Health, Madison, WI 53706, USA
    Neuroscience 206:224-36. 2012
  9. ncbi The influence of inhalative corticosteroids on circulating Nerve Growth Factor, Brain-Derived Neurotrophic Factor and Neurotrophin-3 in allergic asthmatics
    O Noga
    Allergy and Asthma Clinic, Charite Campus Virchow, Humboldt University Berlin, Germany
    Clin Exp Allergy 31:1906-12. 2001
  10. ncbi NGF, BDNF, leptin, and mast cells in human coronary atherosclerosis and metabolic syndrome
    G N Chaldakov
    Medical University, Varna, Bulgaria
    Arch Physiol Biochem 109:357-60. 2001

Scientific Experts

Detail Information

Publications146 found, 100 shown here

  1. pmc Production and characterization of biologically active recombinant beta nerve growth factor
    F Hallbook
    Department of Medical Genetics, Uppsala University, Sweden
    Mol Cell Biol 8:452-6. 1988
    DNA fragments encoding either rat or chicken beta nerve growth factor (NGF) were inserted in the expression vector p91023(B) for transient expression in COS cells...
  2. pmc NGF and BDNF signaling control amyloidogenic route and Abeta production in hippocampal neurons
    Carmela Matrone
    Institute of Neurobiology and Molecular Medicine, Consiglio Nazionale delle Ricerche, Via del Fosso di Fiorano 64, 00143 Rome, Italy
    Proc Natl Acad Sci U S A 105:13139-44. 2008
    Here, we report that interruption of NGF or BDNF signaling in hippocampal neurons rapidly activates the amyloidogenic pathway and causes neuronal apoptotic death...
  3. pmc Paraplegia increased cardiac NGF content, sympathetic tonus, and the susceptibility to ischemia-induced ventricular tachycardia in conscious rats
    Heidi L Lujan
    Department of Physiology, Wayne State Univ School of Medicine, 540 E Canfield Ave, Detroit, MI 48201, USA
    Am J Physiol Heart Circ Physiol 296:H1364-72. 2009
    ..Furthermore, it is well known that sympathetic neurons have a lifelong requirement for nerve growth factor (NGF)...
  4. pmc The role of enhanced cutaneous IL-1beta signaling in a rat tibia fracture model of complex regional pain syndrome
    Wen Wu Li
    Physical Medicine and Rehabilitation Service, Veterans Affairs Palo Alto Health Care System, Palo Alto, CA 94304, USA
    Pain 144:303-13. 2009
    ..the modulation of nociceptive information and it acts as an intermediate inflammatory mediator via up-regulation of NGF. We hypothesized that IL-1beta signaling might mediate the development of the CRPS-like changes after tibial ..
  5. pmc Endogenous nerve growth factor regulates collagen expression and bladder hypertrophy through Akt and MAPK pathways during cystitis
    Chul Won Chung
    Department of Physiology and Biophysics, Virginia Commonwealth University School of Medicine, Richmond, Virginia 23298 0551, USA
    J Biol Chem 285:4206-12. 2010
    ..The endogenous nerve growth factor (NGF) in the urinary bladder regulated type I collagen expression because the neutralizing NGF antibody attenuated ..
  6. pmc Global expression analysis identified a preferentially nerve growth factor-induced transcriptional program regulated by sustained mitogen-activated protein kinase/extracellular signal-regulated kinase (ERK) and AP-1 protein activation during PC12 cell dif
    Steven Mullenbrock
    Department of Biology, Boston University, Boston, Massachusetts 02215, USA
    J Biol Chem 286:45131-45. 2011
    Neuronal differentiation of PC12 cells in response to NGF is a prototypical model in which signal duration determines a biological response...
  7. ncbi Nerve growth factor-mediated increases in protein methylation occur predominantly at type I arginine methylation sites and involve protein arginine methyltransferase 1
    Thomas R Cimato
    Department of Pharmacology and Toxicology, University at Buffalo School of Medicine and Biomedical Sciences, State University of New York, 3435 Main Street, Buffalo, NY 14214 3000, USA
    J Neurosci Res 67:435-42. 2002
    Nerve growth factor (NGF)-specific signal transduction leads to changes in protein methylation during neuronal differentiation of PC12 cells (Cimato et al. [1997] J. Cell Biol. 138:1089-1103)...
  8. pmc Selective inhibition of extracellular signal-regulated kinases 1/2 blocks nerve growth factor to brain-derived neurotrophic factor signaling and suppresses the development of and reverses already established pain behavior in rats
    Y Matsuoka
    Department of Anesthesiology, University of Wisconsin School of Medicine and Public Health, Madison, WI 53706, USA
    Neuroscience 206:224-36. 2012
    ..Although it is known that nerve growth factor (NGF) induces BDNF mRNA through extracellular signal-regulated kinases (ERK), whether ERK1/2 or ERK5, two closely ..
  9. ncbi The influence of inhalative corticosteroids on circulating Nerve Growth Factor, Brain-Derived Neurotrophic Factor and Neurotrophin-3 in allergic asthmatics
    O Noga
    Allergy and Asthma Clinic, Charite Campus Virchow, Humboldt University Berlin, Germany
    Clin Exp Allergy 31:1906-12. 2001
    The neurotrophins Nerve Growth Factor (NGF), Brain-Derived Neurotrophic Factor (BDNF) and Neurotrophin (NT)-3 are produced, stored and released by various immunological cells...
  10. ncbi NGF, BDNF, leptin, and mast cells in human coronary atherosclerosis and metabolic syndrome
    G N Chaldakov
    Medical University, Varna, Bulgaria
    Arch Physiol Biochem 109:357-60. 2001
    ..implicated in cardiovascular tissue development and in lipid and glucose metabolism, the role of the neurotrophins NGF and BDNF and also the adipokine leptin in human coronary atherosclerosis and related disorders, such as metabolic ..
  11. ncbi A study of the cough reflex in idiopathic pulmonary fibrosis
    Benjamin D M Hope-Gill
    Respiratory Unit and Pathology Department, Morriston Hospital, Swansea, United Kingdom
    Am J Respir Crit Care Med 168:995-1002. 2003
    ..The cough response to inhaled SP in most patients may reflect disrupted respiratory epithelium. The response to corticosteroids demonstrates that the cough is amenable to therapy...
  12. ncbi Stress alters vascular-endothelial growth factor expression in rat arteries: role of nerve growth factor
    Luigi Manni
    Institute of Neurobiology and Molecular Medicine, Section of Neurobiology, CNR, Roma, Italy
    Basic Res Cardiol 100:121-30. 2005
    The aim of this study was to investigate the role of stress and nerve growth factor (NGF) on the expression of vascular-endothelial growth factor (VEGF) and NGF high-affinity receptor (tyrosine kinase A, TrKA) in the ascending and ..
  13. ncbi Cardiac NGF and GDNF expression during Trypanosoma cruzi infection in rats
    Patrícia Massara Martinelli
    Department of Morphology, Institute of Biological Sciences, Universidade Federal de Minas Gerais, Av Antonio Carlos 6627, 31270 901, Belo Horizonte, MG, Brazil
    Auton Neurosci 130:32-40. 2006
    ..work shows the cardiac levels of glial cell line-derived neurotrophic factor (GDNF) and nerve growth factor (NGF), and their cellular sources during T. cruzi infection in rats...
  14. ncbi beta-Nerve growth factor participates in an auto/paracrine pathway of regulation of the meiotic differentiation of rat spermatocytes
    Marie Hélene Perrard
    INSERM, U418, Hopital Debrousse, 29 rue Soeur Bouvier, Lyon Cedex 05, France
    J Cell Physiol 210:51-62. 2007
    b>NGF appears to be involved in spermatogenesis. However, mice lacking NGF or TrkA genes do not survive more than a few days whereas p75(NTR) knockout mice are viable and fertile...
  15. ncbi Expression profiles of BDNF splice variants in cultured DRG neurons stimulated with NGF
    Yoshikazu Matsuoka
    Department of Anesthesiology and Resuscitology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama City 700 8558, Japan
    Biochem Biophys Res Commun 362:682-8. 2007
    ..Nerve growth factor (NGF) from inflammatory tissue is thought to induce expression of BDNF...
  16. pmc Blockade of NGF and trk receptors inhibits increased peripheral mechanical sensitivity accompanying cystitis in rats
    Simone D Guerios
    Department of Surgical Sciences, School of Veterinary Medicine, School of Medicine and Public Health, University of Wisconsin, Madison, Wisconsin, USA
    Am J Physiol Regul Integr Comp Physiol 295:R111-22. 2008
    ..may induce transient or persistent plastic changes mediated by neurotrophins, particularly nerve growth factor (NGF), which contribute to increased nociceptive input...
  17. pmc Nerve growth factor attenuates proliferation of astrocytes via the p75 neurotrophin receptor
    Andrea B Cragnolini
    Department of Biological Sciences, Rutgers University, Newark, New Jersey 07102, USA
    Glia 57:1386-92. 2009
    ..Treatment of hippocampal astrocytes with nerve growth factor (NGF) caused a reduction in cell number, but did not elicit an apoptotic response, in contrast to hippocampal neurons...
  18. doi Redundancy of the effect of TGFbeta1 and beta-NGF on the second meiotic division of rat spermatocytes
    Marie Hélene Perrard
    Institut de Génomique Fonctionnelle de Lyon, Universite de Lyon, Université Lyon I, CNRS, INRA, Ecole Normale Superieure de Lyon, Lyon, F 69364, France
    Microsc Res Tech 72:596-602. 2009
    ..in cocultures of late pachytene/diplotene spermatocytes (PS/DS) with Sertoli cells, beta-nerve growth factor (beta-NGF) or transforming growth factor (TGFbeta1) regulates the second meiotic division by blocking secondary spermatocytes ..
  19. pmc Tiam1 as a signaling mediator of nerve growth factor-dependent neurite outgrowth
    Shahrzad Shirazi Fard
    Laboratory of Molecular and Cellular Neuroscience, Department of Neuroscience, Karolinska Institute, Stockholm, Sweden
    PLoS ONE 5:e9647. 2010
    Nerve Growth Factor (NGF)-induced neuronal differentiation requires the activation of members of the Rho family of small GTPases...
  20. doi Norepinephrine-induced nerve growth factor depletion causes cardiac sympathetic denervation in severe heart failure
    Kensuke Kimura
    Department of Regenerative Medicine and Advanced Cardiac Therapeutics, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Auton Neurosci 156:27-35. 2010
    ..of circulating norepinephrine (NE) concentration, we investigated the temporal association of nerve growth factor (NGF) expression in the heart and cardiac sympathetic nerve density during the development of CHF in the continuous NE-..
  21. doi Inhibiting nerve growth factor or its receptors downregulates calcitonin gene-related peptide expression in rat lumbar dorsal root ganglia innervating injured intervertebral discs
    Sumihisa Orita
    Department of Orthopaedic Surgery, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
    J Orthop Res 28:1614-20. 2010
    Nerve growth factor (NGF) and its dual structurally unrelated receptors, tropomyosin-related kinase A (TrkA) or p75 neurotrophin receptor (p75(NTR)), cause the pathogenesis of discogenic pain...
  22. pmc NGF and proNGF regulate functionally distinct mRNAs in PC12 cells: an early gene expression profiling
    Mara D'Onofrio
    Neurotrophic Factors and Neurodegenerative Diseases Unit, EBRI European Brain Research Institute, Rome, Italy
    PLoS ONE 6:e20839. 2011
    The biological activities of NGF and of its precursor proNGF are quite distinct, due to different receptor binding profiles, but little is known about how proNGF regulates gene expression...
  23. doi Impact of the NGF maturation and degradation pathway on the cortical cholinergic system phenotype
    Simon Allard
    Department of Pharmacology and Therapeutics, McGill University, Montreal, Quebec H3G 1Y6, Canada
    J Neurosci 32:2002-12. 2012
    ..Nerve growth factor (NGF) is the neurotrophin responsible for the phenotypic maintenance of basal forebrain cholinergic neurons in the ..
  24. pmc Activation of extracellular signal-regulated protein kinase 5 is essential for cystitis- and nerve growth factor-induced calcitonin gene-related peptide expression in sensory neurons
    Sharon J Yu
    Department of Physiology and Biophysics, Virginia Commonwealth University School of Medicine, Richmond, Virginia, USA
    Mol Pain 8:48. 2012
    ..The molecular mechanism and signal transduction underlying cross talk between the inflamed urinary bladder and sensory sensitization has not been investigated...
  25. pmc BDNF transcripts, proBDNF and proNGF, in the cortex and hippocampus throughout the life span of the rat
    Milka Perovic
    Institute for Biological Research, University of Belgrade, Bulevar Despota Stefana 142, 11060, Belgrade, Serbia
    Age (Dordr) 35:2057-70. 2013
    ..We analyzed the impact of aging on brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) protein isoforms, their receptors, and on the expression patterns of multiple 5' exon-specific BDNF transcripts in ..
  26. doi NGF induces adult stem Leydig cells to proliferate and differentiate during Leydig cell regeneration
    Lei Zhang
    Department of Cell Biology, College of Life Science and Technology, Jinan University, 510632 Guangzhou, PR China
    Biochem Biophys Res Commun 436:300-5. 2013
    Nerve growth factor (NGF) has been reported to be involved in male reproductive physiology. However, few reports have described the activity of NGF during Leydig cell development...
  27. ncbi Neurotrophin system activation in bronchoalveolar lavage fluid immune cells in pulmonary sarcoidosis
    Alberto Ricci
    Dipartimento di Scienze Cardiovascolari e Respiratorie, U O C Pneumologia Ospedale Sant Andrea, Universita La Sapienza Roma, Italy
    Sarcoidosis Vasc Diffuse Lung Dis 22:186-94. 2005
    ..We hypothesize that neurotrophins (NTs), nerve growth factor (NGF), brain derived neurotrophic factor (BDNF) and NT-3, besides their importance in immune system activities, ..
  28. doi Identification of new Nerve Growth Factor-responsive immediate-early genes
    T F Dijkmans
    Division of Medical Pharmacology, Leiden Amsterdam Center for Drug Research, Leiden University Medical Center, PO Box 9502, 2300 RA, Leiden, The Netherlands
    Brain Res 1249:19-33. 2009
    Stimulation of the PC12 pheochromocytoma cell line with the prototypical neurotrophin Nerve Growth Factor (NGF) induces a cellular response of neuronal differentiation and is therefore a widely used model to gain molecular insight into ..
  29. ncbi Stretch-activated signaling of nerve growth factor secretion in bladder and vascular smooth muscle cells from hypertensive and hyperactive rats
    D B Clemow
    Department of Neuroscience, University of Virginia School of Medicine, Charlottesville, Virginia 22908, USA
    J Cell Physiol 183:289-300. 2000
    Elevated vascular (VSMC) and bladder smooth muscle (BSMC) NGF are associated with altered visceral innervation in the spontaneously hypertensive rat (SHR: hypertensive, behaviorally hyperactive) compared with control Wistar-Kyotos (WKYs)...
  30. ncbi Nerve growth factor levels and mast cell distribution in human coronary atherosclerosis
    G N Chaldakov
    Division of Electron Microscopy, Department of Forensic Medicine, Medical University, Varna, Bulgaria
    Atherosclerosis 159:57-66. 2001
    Nerve growth factor (NGF), in addition to its neurotrophic function, acts on a variety of non-neuronal cells including immune cells and vascular smooth muscle cells...
  31. ncbi [Effects of Jinmaitong capsule on nerve growth factor in diabetic rats]
    Ling Qu
    Department of Traditional Chinese Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing 100730, China
    Zhongguo Zhong Yao Za Zhi 33:2539-44. 2008
    To study the effects of Jinmaitong Capsule (JMT) on the expression of NGF and NGF mRNA in STZ-induced diabetic rats.
  32. pmc Reactive oxygen species, Ki-Ras, and mitochondrial superoxide dismutase cooperate in nerve growth factor-induced differentiation of PC12 cells
    Silvana Cassano
    Dipartimento di Biologia e Patologia Molecolare e Cellulare, Istituto di Endocrinologia ed Oncologia Sperimentale del Consiglio Nazionale delle Ricerche
    J Biol Chem 285:24141-53. 2010
    Nerve growth factor (NGF) induces terminal differentiation in PC12, a pheochromocytoma-derived cell line. NGF binds a specific receptor on the membrane and triggers the ERK1/2 cascade, which stimulates the transcription of neural genes...
  33. doi The impact of short-lasting repeated vibrations on retrograde axonal transport, the expression of CGRP and parvalbumin in lower lumbar dorsal root ganglia
    Jaroslav Pavel
    Institute of Neurobiology, Slovak Academy of Sciences, Kosice, Slovak Republic
    Brain Res 1396:1-10. 2011
    ..CGRP protein expression determined by Western blot analysis and optical density measurement, and NGF level measured by ELISA have been decreased, markedly only at the L4 DRG...
  34. ncbi [Changes of nerve growth factor and M3 subtype muscarinic receptor in the seminal vesicle of diabetic rats]
    Hai e Chen
    Research Institute of Family Planning, Tongjin Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China
    Zhonghua Nan Ke Xue 17:1002-6. 2011
    ..and search for the theoretical evidence for the prevention and treatment of diabetic infertility by observing changes in the contents of the nerve growth factor (NGF) and muscarinic M3 receptor in the seminal vesicle of diabetic rats.
  35. doi Influence of estrogen replacement and aging on the expression of nerve growth factor in the urethra of female rats
    Eliana V M Zucchi
    Department of Gynecology, University Federal of São Paulo, Sao Paulo SP, Brazil
    Neurourol Urodyn 31:702-5. 2012
    To evaluate the expression of nerve growth factor (NGF) in the urethra of adult female rats in different hormonal status using immunohistochemical assay.
  36. pmc Neural mobilization reverses behavioral and cellular changes that characterize neuropathic pain in rats
    Fabio M Santos
    Department of Anatomy, Laboratory of Functional Neuroanatomy of Pain, Sao Paulo, Brazil
    Mol Pain 8:57. 2012
    ..At the end of the sessions, the dorsal root ganglion (DRG) and spinal cord were analyzed using immunohistochemistry and Western blot assays for neural growth factor (NGF) and glial fibrillary acidic protein (GFAP).
  37. doi The relation among NGF, EGF and insulin is important for triggering pancreatic β cell apoptosis
    S Gezginci-Oktayoglu
    Department of Biology, Istanbul University, Istanbul, Turkey
    Diabetes Metab Res Rev 28:654-62. 2012
    Nerve growth factor (NGF) is a well-known mediator for maintaining the survival of neurons, while recent studies report that its absence induces apoptosis in cultured β cells of humans and rats...
  38. doi Nerve growth factor-mediated regulation of pain signalling and proposed new intervention strategies in clinical pain management
    Laura McKelvey
    Department of Anatomy and Neuroscience, University College Cork, Cork, Ireland
    J Neurochem 124:276-89. 2013
    Nerve growth factor (NGF) is the founding member of the neurotrophins family of proteins...
  39. doi Effect of nerve growth factor on the in vitro induction of apoptosis of human conjunctival epithelial cells by hyperosmolar stress
    Soon Suk Kang
    Department of Ophthalmology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea
    Invest Ophthalmol Vis Sci 55:535-41. 2014
    To evaluate the effects of nerve growth factor (NGF), which is activated during inflammatory episodes of ocular diseases, on the apoptotic response in cultured human primary conjunctival epithelial cells (pHCECs).
  40. pmc proNGF/NGF mixtures induce gene expression changes in PC12 cells that neither singly produces
    Ivan Arisi
    Neurotrophic Factors and Neurodegenerative Diseases Laboratory, European Brain Research Institute EBRI Rita Levi Montalcini, Via del Fosso di Fiorano, 64, 00143 Roma, Italy
    BMC Neurosci 15:48. 2014
    Growing evidence shows that, in vivo, the precursor of Nerve Growth Factor (NGF), proNGF, displays biological activities different from those of its mature NGF counterpart, mediated by distinct, and somewhat complementary, receptor ..
  41. doi The effect of mild stress stimulation on the nerve growth factor (NGF) and tyrosine kinase receptor A (TrkA) immunoreactivity in the paraventricular nucleus (PVN) of the hypothalamus and hippocampus in aged vs. adult rats
    E Badowska-Szalewska
    Department of Anatomy and Neurobiology, Medical University of Gdansk, Dębinki Street 1, 80 211 Gdansk, Poland Electronic address
    Neuroscience 290:346-56. 2015
    Ontogenetic life and stress can have different effects on the nerve growth factor (NGF) and its tyrosine kinase receptor A (TrkA) in the structures of the limbic system...
  42. ncbi Immune System Induction of Nerve Growth Factor in an Animal Model of Multiple Sclerosis: Implications in Re-Myelination and Myelin Repair
    Crystal Acosta
    College of Pharmacy, Faculty of Health Science, University of Manitoba, 750 McDermot Avenue, Winnipeg, Manitoba, Canada
    CNS Neurol Disord Drug Targets 14:1069-78. 2015
    Nerve growth factor (NGF) expression is augmented during neuroinflammation...
  43. pmc Intra-articular nerve growth factor regulates development, but not maintenance, of injury-induced facet joint pain & spinal neuronal hypersensitivity
    J V Kras
    Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104, USA Electronic address
    Osteoarthritis Cartilage 23:1999-2008. 2015
    The objective of the current study is to define whether intra-articular nerve growth factor (NGF), an inflammatory mediator that contributes to osteoarthritic pain, is necessary and sufficient for the development or maintenance of injury-..
  44. doi Protective effects of matrine on experimental autoimmune encephalomyelitis via regulation of ProNGF and NGF signaling
    Lin Zhu
    Department of Pharmacy, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan, China
    Exp Mol Pathol 100:337-43. 2016
    ..At the same time, MAT also prevented a decrease in the levels of NGF and its receptor TrkA, which together mediate the cell survival pathway and differentiation of OLGs...
  45. ncbi Immunohistochemical localization of nerve growth factor in fractured and unfractured rat bone
    B L Grills
    School of Human Biosciences, Department of Physiology and Anatomy, La Trobe University, Bundoora, Victoria, Australia
    Acta Orthop Scand 69:415-9. 1998
    We detected nerve growth factor (NGF) by immunohistochemical localization in both fractured and unfractured rat rib...
  46. ncbi Intravesical Escherichia coli lipopolysaccharide stimulates an increase in bladder nerve growth factor
    D E Bjorling
    Department of Surgical Sciences, School of Veterinary Medicine, University of Wisconsin, Madison, WI 53706, USA
    BJU Int 87:697-702. 2001
    To investigate the effects of the intravesical instillation of Escherichia coli lipopolysaccharide (LPS) on nerve growth factor (NGF, which may mediate the pain associated with inflammation) protein and mRNA in the bladders of mice.
  47. ncbi Intravesical botulinum toxin A injections plus hydrodistension can reduce nerve growth factor production and control bladder pain in interstitial cystitis
    Hsin Tzu Liu
    Department of Urology, Buddhist Tzu Chi General Hospital and Buddhist Tzu Chi University School of Medicine, Hualien, Taiwan
    Urology 70:463-8. 2007
    To investigate the level of nerve growth factor (NGF) mRNA in bladder tissue and the effect of botulinum toxin A (BTX-A) treatment in patients with interstitial cystitis (IC).
  48. doi Antagonism of macrophage migration inhibitory factor decreases cyclophosphamide cystitis in mice
    Pedro L Vera
    The Bay Pines VA Healthcare System, Bay Pines, Florida, USA
    Neurourol Urodyn 29:1451-7. 2010
    ..Therefore, we examined the effects of a MIF tautomerase inhibitor (ISO-1; also blocks biological activity) on cyclophosphamide (CYP)-induced cystitis in mice...
  49. pmc Expression of axonal protein degradation machinery in sympathetic neurons is regulated by nerve growth factor
    John P Frampton
    Department of Biologic and Materials Sciences, University of Michigan School of Dentistry, Ann Arbor, Michigan 48109, USA
    J Neurosci Res 90:1533-46. 2012
    ..the expression of proteins associated with lysosomes and proteasomes were upregulated selectively in axons by NGF stimulation of the distal axons of sympathetic neurons, suggesting that axonal growth and maintenance requires ..
  50. ncbi Development of heat hyperalgesia and changes of TRPV1 and NGF expression in rat dorsal root ganglion following joint immobilization
    T Nishigami
    Department of Physical Therapy, Konan Woman s University, Kobe, Japan
    Physiol Res 62:215-9. 2013
    ..to heat stimuli, and expression of transient receptor potential vanilloid1 (TRPV1) and nerve growth factor (NGF) in dorsal root ganglion (DRG) altered under conditions of long-term limb immobilization...
  51. ncbi [Study on the expressions of basic fibroblast growth factor and nervous growth factor genes in rat cerebral concussion]
    Rui Yun Peng
    Institute of Radiation Medicine, Academy of Military Medical Sciences, Beijing 100850, China
    Zhongguo Wei Zhong Bing Ji Jiu Yi Xue 15:213-6. 2003
    To study the expressions of basic fibroblast growth factor (bFGF) and nervous growth factor(NGF) genes in rat cerebral concussion.
  52. ncbi Gene therapy using replication-defective herpes simplex virus vectors expressing nerve growth factor in a rat model of diabetic cystopathy
    Katsumi Sasaki
    Department of Urology, University of Pittsburgh School of Medicine, PA, USA
    Diabetes 53:2723-30. 2004
    ..replication-defective herpes simplex virus type 1 (HSV-1) vectors to deliver and express the nerve growth factor (NGF) gene (HSV-NGF) on tissue NGF levels and bladder function, were evaluated in streptozotocin (STZ)-induced diabetic ..
  53. ncbi Nerve growth factor mediates peripheral mechanical hypersensitivity that accompanies experimental cystitis in mice
    Simone Domit Guerios
    Department of Surgical Sciences, School of Veterinary Medicine, University of Wisconsin, 2015 Linden Dr, Madison, 53706, USA
    Neurosci Lett 392:193-7. 2006
    ..To investigate the role of nerve growth factor (NGF) in these processes, other groups of mice received NGF antiserum, normal serum, or K252a intravenously 30 min after ..
  54. doi Functional characterization of a chronic cyclophosphamide-induced overactive bladder model in mice
    Mathieu Boudes
    Laboratory of Ion Channel Research, Department of Molecular Cell Biology, KU Leuven, Leuven, Belgium
    Neurourol Urodyn 30:1659-65. 2011
    ..To describe a new mouse model of overactive bladder (OAB) at the histological level, pain, voiding behavior, and urodynamics, while assessing the physiological state of mice...
  55. doi Rate and irregularity of electrical activation during atrial fibrillation affect myocardial NGF expression via different signalling routes
    Erol Saygili
    Department of Cardiology, University RWTH Aachen, Aachen, Germany
    Cell Signal 24:99-105. 2012
    ..This study aimed to investigate the impact of rate and irregularity on nerve growth factor (NGF) expression in cardiomyocytes, since NGF is known to be the main contributor to cardiac sympathetic innervation ..
  56. doi Ras signaling in NGF reduction and TNF-α-related pancreatic β cell apoptosis in hyperglycemic rats
    Selda Gezginci-Oktayoglu
    Department of Biology, Istanbul University, Vezneciler, Istanbul, Turkey
    Apoptosis 17:14-24. 2012
    Recent evidence suggested that tumor necrosis factor-alpha (TNF-α) and nerve growth factor (NGF) withdrawal activated a common apoptotic pathway...
  57. pmc Effects of castration on the expression of the NGF and TrkA in the vas deferens and accessory male genital glands of the rat
    C Squillacioti
    Department of Structures, Functions and biological Technologies University of Naples Federico II
    Eur J Histochem 53:e29. 2009
    Nerve Growth Factor (NGF) is a member of the neurotrophin family...
  58. pmc Matrix metalloproteinase-7 regulates cleavage of pro-nerve growth factor and is neuroprotective following kainic acid-induced seizures
    Audrey P Le
    Department of Biological Sciences, Center for Molecular and Behavioral Neuroscience, Rutgers University, Newark, New Jersey 07102, USA
    J Neurosci 32:703-12. 2012
    The neurotrophin nerve growth factor (NGF) regulates neuronal growth, differentiation, and survival during development...
  59. ncbi [Observation on morphology and nerve growth factor expression in nasal mucosal of depression rats]
    Xiaobei Xu
    Department of Otorhinolaryngology Head and Neck Surgery, Wuhan University People s Hospital, Wuhan, 430060, China
    Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 26:71-4. 2012
    To establish the rat model of depression and observe its morphological changes and nerve growth factor (NGF) expression in nasal mucosal.
  60. doi Serum and tear levels of nerve growth factor in diabetic retinopathy patients
    Kyoung Soo Park
    Institute of Vision Research, Department of Ophthalmology, Yonsei University College of Medicine, Seoul, Korea
    Am J Ophthalmol 145:432-7. 2008
    To measure serum and tear nerve growth factor (NGF) concentrations in diabetic retinopathy (DR) patients to determine whether the NGF correlated with parameters associated with DR.
  61. doi Calreticulin mediates nerve growth factor-induced neuronal differentiation
    Yu Yin Shih
    Laboratory of Molecular Neurobiology, Institute of Cellular and Organismic Biology, Academia Sinica, Taipei, 11529, Taiwan
    J Mol Neurosci 47:571-81. 2012
    The nerve growth factor (NGF)/TrkA-signaling is necessary for neural development, and its abnormality has been tightly associated with the tumorigenesis of various cancers originated from the nervous system...
  62. ncbi Decreased expression of β-nerve growth factor correlated with histological changes in a cryptorchidism rat model
    Hua XIAN
    Surgical Comprehensive Laboratory, Affiliated Hospital of Nantong University, Nantong, Jiangsu, China
    Chin Med J (Engl) 125:713-6. 2012
    Nerve growth factor (NGF) is well-known for its important role in the development and maintenance of the nervous system...
  63. pmc Use new PLGL-RGD-NGF nerve conduits for promoting peripheral nerve regeneration
    Qiongjiao Yan
    Biomedical Materials and Engineering Center, Wuhan University of Technology, Wuhan, Peoples Republic of China
    Biomed Eng Online 11:36. 2012
    ..Nerve conduits require additional factors such as cell adhesion molecules and neurotrophic factors to provide a more conducive microenvironment for nerve regeneration...
  64. doi Urinary nerve growth factor level in children with neurogenic bladder due to myelomeningocele
    Agata Korzeniecka-Kozerska
    Department of Paediatrics and Nephrology, Medical University of Białystok, Białystok, Poland
    Scand J Urol 47:411-7. 2013
    ..Nerve growth factor (NGF) is an important mediator inducing bladder overactivity in many pathological conditions...
  65. doi Vascular and neuronal protection induced by the ocular administration of nerve growth factor in diabetic-induced rat encephalopathy
    Paola Tirassa
    Institute of Cellular Biology and Neurobiology, National Research Council CNR, Rome, Italy
    CNS Neurosci Ther 19:307-18. 2013
    ..The major NGF brain target areas, such as the septum and the hippocampus, were used as an experimental paradigma to test this ..
  66. ncbi mRNA for NGF and p75 in the central nervous system of rats affected by experimental allergic encephalomyelitis
    R De Simone
    Institute of Neurobiology, CNR, Rome, Italy
    Neuropathol Appl Neurobiol 22:54-9. 1996
    In this study we measured the concentration of nerve growth factor (NGF) and the expression of NGF and the low affinity NGF-receptor (NGF-r) mRNA in the central nervous system (CNS) of rats affected by experimental allergic ..
  67. ncbi Nerve growth factor induces systemic hyperalgesia after thoracic burn injury in the rat
    Masashi Ueda
    Department of Anesthesiology, Kyoto Prefectural University of Medicine, Kamikyo ku, Kyoto, 602 0841, Japan
    Neurosci Lett 328:97-100. 2002
    ..The concentration of nerve growth factor (NGF) in the skin of the chest increased markedly during the healing stage...
  68. ncbi Attenuation of mechanical hyperalgesia following spinal cord injury by administration of antibodies to nerve growth factor in the rat
    Young Seob Gwak
    Department of Physiology, Brain Research Institute, and BK21 Project for Medical Science, Yonsei University College of Medicine, CPO Box 8044, Seoul 120 752, South Korea
    Neurosci Lett 336:117-20. 2003
    ..Since there is evidence that nerve growth factor (NGF) contributes to pain-related behaviors, we wished to determine if anti-NGF might inhibit abnormal somatosensory ..
  69. ncbi Bone marrow stromal cells produce nerve growth factor and glial cell line-derived neurotrophic factors
    Rocio Garcia
    International Center for Neurological Restoration, Havana City, Cuba
    Biochem Biophys Res Commun 316:753-4. 2004
    ..The objective of this work was determine whether rat BMSC express NGF and GDNF, in order to study its potential application for treatment of neurodegenerative diseases...
  70. ncbi S100B increases proliferation in PC12 neuronal cells and reduces their responsiveness to nerve growth factor via Akt activation
    Cataldo Arcuri
    Section of Anatomy, Department of Experimental Medicine and Biochemical Sciences, University of Perugia, 06122 Perugia, Italy
    J Biol Chem 280:4402-14. 2005
    ..following: (i) proliferation was higher in S100B+ PC12 cells than in S100B- PC12 cells; (ii) nerve growth factor (NGF), which decreased the proliferation of S100B- PC12 cells, was less effective in the case of S100B+ PC12 cells; (iii)..
  71. ncbi Molecular and behavioral changes in nociception in a novel rat model of chronic pancreatitis for the study of pain
    John H Winston
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, The University of Texas Medical Branch, 4 106 McCullough Building, 301 University Boulevard, Galveston TX 77555 0764, USA
    Pain 117:214-22. 2005
    ..and substance P (SP) in the thoracic dorsal root ganglia receiving input from the pancreas and nerve growth factor (NGF) in the pancreas were measured...
  72. ncbi Neuronal loss and expression of neurotrophic factors in a model of rat chronic compressive spinal cord injury
    Kazuma Kasahara
    Department of Neurosurgery, University of Fukui, Fukui, Japan
    Spine (Phila Pa 1976) 31:2059-66. 2006
    ..An experimental animal study about neuronal loss and the expression of neurotrophic factors in the chronic compressive spinal cords...
  73. ncbi [Experimental study on the mechanisms of regulating airway neurogenic inflammation in asthma by never growth factor and leukemia inhibitory factor]
    Jin Qi Zhu
    Department of Respiratory Medicine, Xiangya Hospital of Central South University, Changsha 410008, China
    Zhonghua Jie He He Hu Xi Za Zhi 29:376-80. 2006
    To study the mechanisms of regulating airway neurogenic inflammation in asthma by never growth factor (NGF) and leukemia inhibitory factor (LIF), and then to explore new targets in treating asthma.
  74. ncbi Aldose reductase inhibitor ONO-2235 restores the alterations of bladder nerve growth factor and neurotrophin receptor p75 genetic expression in streptozotocin induced diabetic rats
    Yat Ching Tong
    Departments of Urology and Pharmacology, School of Medicine, National Cheng Kung University, Tainan, Taiwan, Republic of China
    J Urol 178:2203-7. 2007
    ....
  75. ncbi Thrombopoietin inhibits nerve growth factor-induced neuronal differentiation and ERK signalling
    Anatoly Samoylenko
    University of Wurzburg, Section of Experimental Neurosurgery, Department of Neurosurgery, Josef Schneider St 11, 97080 Wurzburg, Germany
    Cell Signal 20:154-62. 2008
    ..Surprisingly, TPO inhibited nerve growth factor (NGF)-induced differentiation of PC12 cells in a dose- and time-dependent manner...
  76. doi Bone marrow stromal cells control the growth of hepatic stellate cells in vitro
    Lijun Shi
    Department of Gastroenterology, the First Affiliated Clinic College of Harbin Medical University, Heilongjiang, China
    Dig Dis Sci 53:2969-74. 2008
    ..The effect of BMSCs on the apoptosis of HSCs is possibly via the JNK pathway activated by nerve growth factor (NGF) and hepatocyte growth factor (HGF) secreted by BMSCs...
  77. doi Dissecting NGF interactions with TrkA and p75 receptors by structural and functional studies of an anti-NGF neutralizing antibody
    Sonia Covaceuszach
    Lay Line Genomics SpA, Via di Castel Romano 100, I 00128 Rome, Italy
    J Mol Biol 381:881-96. 2008
    The anti-nerve growth factor (NGF) monoclonal antibody alphaD11 is a potent antagonist that neutralizes the biological functions of its antigen in vivo...
  78. ncbi Nerve growth factor promotes development of glucose-induced insulin secretion in rat neonate pancreatic beta cells by modulating calcium channels
    Victor Navarro-Tableros
    Departamento de Biofisica, Universidad Nacional Autonoma de Mexico UNAM, Mexico City, Mexico
    Channels (Austin) 1:408-16. 2007
    ..Adult rat beta cells synthesize and secrete nerve growth factor (NGF) and express NGF receptors...
  79. ncbi [The expression of NGF after rat diffuse axonal injury]
    Zong Yun Chen
    Department of Forensic Medicine, Wannan Medical College, Wuhu 241000, China
    Fa Yi Xue Za Zhi 24:172-4. 2008
    To study the expression of nerve growth factor (NGF) in diffuse axonal injury (DAI) in rat.
  80. doi Nerve sprouting suppresses myocardial I(to) and I(K1) channels and increases severity to ventricular fibrillation in rat
    Chongyu Ren
    Department of Physiology and Pathophysiology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College, Beijing, PR China
    Auton Neurosci 144:22-9. 2008
    ..nerve sprouting by chronic subcutaneous injection of 4-methylcatechol, a potent stimulator of nerve growth factor (NGF) synthesis. Cardiac sympathetic nerves were visualized by immunohistochemical staining...
  81. doi Effects of nicergoline on corneal epithelial wound healing in rat eyes
    Su Young Kim
    Department of Ophthalmology and Visual Science, College of Medicine, The Catholic University of Korea, Seoul, Korea
    Invest Ophthalmol Vis Sci 50:621-5. 2009
    ..To investigate the effect of nicergoline on corneal epithelial wound healing in rats...
  82. doi Glaucoma alters the expression of NGF and NGF receptors in visual cortex and geniculate nucleus of rats: effect of eye NGF application
    Valentina Sposato
    Institute of Neurobiology and Molecular Medicine, Section of Neurobiology, National Research Council CNR, Via del Fosso di Fiorano, 64 65, I 00143 Rome, Italy
    Vision Res 49:54-63. 2009
    We investigated the effect of glaucoma (GL) on nerve growth factor (NGF) presence in two brain visual areas...
  83. doi Gene expression profiles of neurotrophic factors in rat cultured spinal cord cells under cyclic tensile stress
    Kenzo Uchida
    Department of Orthopaedics and Rehabilitation Medicine, Fukui University Faculty of Medical Sciences, Fukui, Japan
    Spine (Phila Pa 1976) 33:2596-604. 2008
    ..An experimental study to investigate the in vitro gene expression of neurotrophic factors and receptors in cultured rat spinal cord cells subjected to cyclic mechanical stretch forces...
  84. pmc Modulation of rat parasympathetic cardiac ganglion phenotype and NGF synthesis by adrenergic nerves
    Wohaib Hasan
    Department of Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    Auton Neurosci 145:17-26. 2009
    ..Parasympathetic neurons elsewhere synthesize the neurotrophin NGF, which may promote postganglionic axonal associations where parasympathetic axons inhibit sympathetic transmitter ..
  85. doi Combination therapy with intranasal NGF and electroacupuncture enhanced cell proliferation and survival in rats after stroke
    Songming Cheng
    Department of Neurology, Jinling Hospital, Nanjing University School of Medicine, Nanjing, China
    Neurol Res 31:753-8. 2009
    ..to investigate the effects of the combination therapy with intranasal (IN) administration of nerve growth factor (NGF) and electroacupuncture (EA) on neural progenitors and neurological functional recovery in adult rats after focal ..
  86. doi In vitro effects of low-level laser irradiation for bone marrow mesenchymal stem cells: proliferation, growth factors secretion and myogenic differentiation
    Jian feng Hou
    Department of Surgery, Cardiovascular Institute and Fu Wai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People s Republic of China
    Lasers Surg Med 40:726-33. 2008
    ..However, little is known about the effects of LLLI on BMSCs. The aim of this study was designed to investigate the influence of LLLI at different energy densities on BMSCs proliferation, secretion and myogenic differentiation...
  87. pmc The roles of nerve growth factor and cholecystokinin in the enhancement of morphine analgesia in a rodent model of central nervous system inflammation
    Dimitris N Xanthos
    Department of Anesthesia, McGill University, Montreal, Quebec, Canada
    Neuropharmacology 56:684-91. 2009
    ..the mechanisms underlying this effect, in particular the roles of cholecystokinin (CCK) and nerve growth factor (NGF), in an animal model of central nervous system (CNS) inflammation induced by spinal administration of ..
  88. doi Regulation of nerve growth factor in the heart: the role of the calcineurin-NFAT pathway
    Obaida R Rana
    Department of Cardiology, Angiology and Pulmonology, Medical Faculty, RWTH Aachen University, Pauwelsstr 30, D 52074 Aachen, Germany
    J Mol Cell Cardiol 46:568-78. 2009
    ..Cardiomyocytes control their local neural milieu by expression of nerve growth factor (NGF), which triggers sympathetic neural growth (sympathetic nerve sprouting: SNS)...
  89. doi NGF protects paravertebral but not prevertebral sympathetic neurons against exposure to high glucose in vitro
    Yemane K Semra
    Research Department of Cell and Developmental Biology, Division of Biosciences, UCL, London, UK
    Brain Res 1285:164-73. 2009
    ..Changes in neurotrophic support by NGF occur during postnatal development and are implicated in diabetic neuropathy...
  90. doi Forced, moderate-intensity treadmill exercise suppresses apoptosis by increasing the level of NGF and stimulating phosphatidylinositol 3-kinase signaling in the hippocampus of induced aging rats
    Chang Hun Chae
    School of Sport Science, Sungkyunkwan University, Chunchun dong, Jangan gu, Suwon 440 746, South Korea
    Neurochem Int 55:208-13. 2009
    While nerve growth factor (NGF) activates various signaling cascades, the phosphatidylinositol 3-kinase (PI3-K)/Akt pathway plays a pivotal role in controlling the survival of neurons, although this activity declines during the aging ..
  91. pmc ERK5 activity is required for nerve growth factor-induced neurite outgrowth and stabilization of tyrosine hydroxylase in PC12 cells
    Yutaro Obara
    Department of Cellular Signaling, Graduate School of Pharmaceutical Sciences, Tohoku University, Aoba, Aramaki, Aoba ku, Sendai 980 8578, Japan
    J Biol Chem 284:23564-73. 2009
    ..Nerve growth factor (NGF) induced phosphorylation of both ERK5 and ERK1/2, whereas the cAMP analog dibutyryl cAMP (Bt(2)cAMP) caused only ..
  92. pmc Immunohistochemical evaluation of the protein expression of nerve growth factor and its TrkA receptor in rat limbic regions following electroshock seizures
    Giuseppe Conti
    Department of Pharmacology, Georgetown University, Washington, DC 20057, USA
    Neurosci Res 65:201-9. 2009
    ..shock (ECS) decreases neuronal death in limbic system and increases mRNA levels for nerve growth factor (NGF). Thus, the induction of NGF is a potential mechanism for the neuroprotection evoked by repeated ECS...
  93. pmc NGF is essential for hippocampal plasticity and learning
    James M Conner
    Department of Neurosciences, University of California, San Diego, La Jolla, California 92093, USA
    J Neurosci 29:10883-9. 2009
    Nerve growth factor (NGF) is produced in the hippocampus throughout life and is retrogradely trafficked to septal cholinergic neurons, providing a potential mechanism for modulating cholinergic inputs and, thereby, hippocampal plasticity...
  94. pmc Cytostatic factor proteins are present in male meiotic cells and beta-nerve growth factor increases mos levels in rat late spermatocytes
    Marie Hélene Perrard
    Institut de Génomique Fonctionnelle de Lyon, Universite de Lyon, INRA UMR 1288, CNRS UMR 5242, Universite Lyon 1, Ecole Normale Superieure de Lyon, Lyon, France
    PLoS ONE 4:e7237. 2009
    In co-cultures of pachytene spermatocytes with Sertoli cells, beta-NGF regulates the second meiotic division by blocking secondary spermatocytes in metaphase (metaphase II), and thereby lowers round spermatid formation...
  95. pmc Combined effects of chronic nicotine and acute virus exposure on neurotrophin expression in rat lung
    Fernando Urrego
    Ochsner Children s Health Center, New Orleans, Louisiana, USA
    Pediatr Pulmonol 44:1075-84. 2009
    ..Expression of the neurotrophins nerve growth factor (NGF) and brain-derived neurotrophic factor, of their high-affinity tyrosine kinase receptors (trkA and trkB, ..
  96. doi Nerve growth factor enhances Clara cell proliferation after lung injury
    S S Sonar
    Dept of Clinical Chemistry and Molecular Diagnostics, Biomedical Research Center, Hans Meerweinstrasse, 35043 Marburg, Germany
    Eur Respir J 36:105-15. 2010
    ..Nerve growth factor (NGF) has been well described in airway inflammation; however, its likely role in lung repair has not been examined thus ..
  97. pmc Effects of repeated minimal electroshock seizures on NGF, BDNF and FGF-2 protein in the rat brain during postnatal development
    Jinsook Kim
    Interdisciplinary Program in Neuroscience, Georgetown University Medical Center, Washington, DC 20057, USA
    Int J Dev Neurosci 28:227-32. 2010
    ..different stages of postnatal development and examined basic fibroblast growth factor (FGF-2), nerve growth factor (NGF), and brain-derived neurotrophic factor (BDNF) proteins in selected brain regions in which these trophic factors ..
  98. doi Bradykinin and nerve growth factor play pivotal roles in muscular mechanical hyperalgesia after exercise (delayed-onset muscle soreness)
    Shiori Murase
    Department of Neuroscience II, Research Institute of Environmental Medicine, Nagoya University, Nagoya 464 8601, Japan
    J Neurosci 30:3752-61. 2010
    ..B(1) antagonist was ineffective, regardless of the timing of its injection. Upregulation of nerve growth factor (NGF) mRNA and protein occurred in exercised muscle over a comparable time course (12 h to 2 d after LC) for muscle ..

Research Grants9

  1. Lower urinary tract dysfunction in Parkinson's disease
    Naoki Yoshimura; Fiscal Year: 2003
    ..This is a high priority in the urologic care of patients with Parkinson's disease. ..
  2. REGULATION OF BLADDER NGF BY ESTROGEN
    Dale Bjorling; Fiscal Year: 2003
    ..The proposed research will test the hypothesis that the sex hormone estrogen increases nerve growth factor (NGF) release and uptake in the bladder, thereby predisposing to bladder inflammation and accounting for gender-related ..
  3. 2006 AUA/SBUR Summer Research Conference "Urothelial Biology & Bladder Cancer"
    Dale Bjorling; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  4. Neurophysiology and Biomechanics of Urethra in Stress Urinary Incontinence
    Naoki Yoshimura; Fiscal Year: 2008
    ..This is recognized as a high priority in the urologic/gynecologic care of SUI patients. [unreadable] [unreadable]..
  5. AFFERENT PLASTICITY UNDERLYING URETHRAL AND PELVIC PAIN
    Naoki Yoshimura; Fiscal Year: 2010
    ..Secondly, we will explore the regulatory role of two different neurotrophic factors (NGF and GDNF) in the emergence of C-fiber hyperexcitability involved in LUT pain since these two factors reportedly ..
  6. Neurovascular and Behavorial Response to Cystitis
    DALE EDMOND BJORLING; Fiscal Year: 2010
    ..abstract_text> ..
  7. Role of CD14 and TLR4 in Urothelial Response to LPS.
    Dale Bjorling; Fiscal Year: 2004
    ..The long-range goal of this research is to identify strategies to minimize pain and harmful cellular effects associated with cystitis due to LPS-producing gram-negative bacteria. ..
  8. Bladder Pain Gene Therapy with Pro-opiomelanocortin cDNA
    Naoki Yoshimura; Fiscal Year: 2004
    ..This research project is important to provide a solid basis for potential future clinical application. ..
  9. Afferent modulation in bladde dysfunction
    Naoki Yoshimura; Fiscal Year: 2007
    ..abstract not provided ..