Nfkb1

Summary

Gene Symbol: Nfkb1
Description: nuclear factor kappa B subunit 1
Alias: EBP-1, NF-kB, nuclear factor NF-kappa-B p105 subunit, DNA-binding factor KBF1, nuclear factor of kappa light chain gene enhancer in B-cells 1, p105, nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p105
Species: rat

Top Publications

  1. ncbi Clinorotation prevents differentiation of rat myoblastic L6 cells in association with reduced NF-kappa B signaling
    Katsuya Hirasaka
    Department of Nutrition, The University of Tokushima School of Medicine, Tokushima, 3 18 15 Kuramoto cho, Tokushima 770 8503, Japan
    Biochim Biophys Acta 1743:130-40. 2005
  2. ncbi Global ischemia activates nuclear factor-kappa B in forebrain neurons of rats
    J A Clemens
    Eli Lilly and Company, CNS Division, Lilly Research Laboratories, Indianapolis, Ind 46285, USA
    Stroke 28:1073-80; discussion 1080-1. 1997
  3. ncbi Acetylation of nuclear factor-kappaB in rat amygdala improves long-term but not short-term retention of fear memory
    Shiu Hwa Yeh
    Institute of Basic Medical Sciences, Department of Pharmacology, College of Medicine, National Cheng Kung University, Tainan
    Mol Pharmacol 65:1286-92. 2004
  4. ncbi Distinct patterns of intracerebral hemorrhage-induced alterations in NF-kappaB subunit, iNOS, and COX-2 expression
    Xiurong Zhao
    Department of Neurology, Stroke Program, University of Texas Houston Medical School, Houston, Texas 77030, USA
    J Neurochem 101:652-63. 2007
  5. doi Shared principles in NF-kappaB signaling
    Matthew S Hayden
    Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06510, USA
    Cell 132:344-62. 2008
  6. pmc Neuroinflammation activates Mdr1b efflux transport through NFkappaB: promoter analysis in BBB endothelia
    Chuanhui Yu
    Pennington Biomedical Research Center, Baton Rouge, LA, USA
    Cell Physiol Biochem 22:745-56. 2008
  7. doi Regulation of multidrug resistance protein 1 by tumor necrosis factor alpha in cultured glial cells: involvement of nuclear factor-kappaB and c-Jun N-terminal kinase signaling pathways
    Patrick T Ronaldson
    Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, 144 College Street, Toronto, ON, Canada
    Mol Pharmacol 77:644-59. 2010
  8. doi Quercetin and quercitrin protect against cytokine‑induced injuries in RINm5F β-cells via the mitochondrial pathway and NF-κB signaling
    Xiaoqian Dai
    Department of Nutrition and Food Hygiene, School of Public Health, Peking University Health Science Center, Haidian, Beijing 100191, PR China
    Int J Mol Med 31:265-71. 2013
  9. ncbi Improved radiation hybrid map of rat chromosome 2: colocalization of the genes encoding corticotropin-releasing hormone and IL6-receptor with quantitative trait loci regulating the inflammatory response
    J F Laes
    Universite Libre de Bruxelles, IBMM, Gosselies, Belgium
    Cytogenet Cell Genet 92:130-3. 2001
  10. ncbi Helicobacter pylori induces apoptosis of rat gastric parietal cells
    Bruno Neu
    Department of Medicine II, Technical University of Munich, Germany
    Am J Physiol Gastrointest Liver Physiol 283:G309-18. 2002

Research Grants

Detail Information

Publications153 found, 100 shown here

  1. ncbi Clinorotation prevents differentiation of rat myoblastic L6 cells in association with reduced NF-kappa B signaling
    Katsuya Hirasaka
    Department of Nutrition, The University of Tokushima School of Medicine, Tokushima, 3 18 15 Kuramoto cho, Tokushima 770 8503, Japan
    Biochim Biophys Acta 1743:130-40. 2005
    ..Our present results suggest that simulated microgravity such as the 3D-clinorotation may disturb skeletal muscle cell differentiation, at least in part, by inhibiting the NF-kappa B pathway...
  2. ncbi Global ischemia activates nuclear factor-kappa B in forebrain neurons of rats
    J A Clemens
    Eli Lilly and Company, CNS Division, Lilly Research Laboratories, Indianapolis, Ind 46285, USA
    Stroke 28:1073-80; discussion 1080-1. 1997
    ..The present study was performed to determine whether NF-kappa B was activated in vivo by global ischemia in hippocampal CA1 neurons...
  3. ncbi Acetylation of nuclear factor-kappaB in rat amygdala improves long-term but not short-term retention of fear memory
    Shiu Hwa Yeh
    Institute of Basic Medical Sciences, Department of Pharmacology, College of Medicine, National Cheng Kung University, Tainan
    Mol Pharmacol 65:1286-92. 2004
    ..This study provides evidence that HDAC-mediated deacetylation functions as an intranuclear molecular switch culminating in the termination of NF-kappaB transcriptional response that is involved in the formation of fear memory...
  4. ncbi Distinct patterns of intracerebral hemorrhage-induced alterations in NF-kappaB subunit, iNOS, and COX-2 expression
    Xiurong Zhao
    Department of Neurology, Stroke Program, University of Texas Houston Medical School, Houston, Texas 77030, USA
    J Neurochem 101:652-63. 2007
    ..In summary, NF-kappaB activation occurs within minutes and persists for at least a week in response to ICH. This reaction utilizes different NF-kappaB regulatory subunits and is associated with the expression of selected target genes...
  5. doi Shared principles in NF-kappaB signaling
    Matthew S Hayden
    Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06510, USA
    Cell 132:344-62. 2008
    ..Here, we attempt to synthesize some of the basic principles that have emerged from studies of NF-kappaB, and we aim to generate a more unified view of NF-kappaB regulation...
  6. pmc Neuroinflammation activates Mdr1b efflux transport through NFkappaB: promoter analysis in BBB endothelia
    Chuanhui Yu
    Pennington Biomedical Research Center, Baton Rouge, LA, USA
    Cell Physiol Biochem 22:745-56. 2008
    ..This study further determines the mechanisms by which TNF activates mdr1b promoter activity...
  7. doi Regulation of multidrug resistance protein 1 by tumor necrosis factor alpha in cultured glial cells: involvement of nuclear factor-kappaB and c-Jun N-terminal kinase signaling pathways
    Patrick T Ronaldson
    Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, 144 College Street, Toronto, ON, Canada
    Mol Pharmacol 77:644-59. 2010
    ..Furthermore, our results imply that both NF-kappaB and JNK signaling are involved in Mrp1 regulation during an HIV-1 associated inflammatory response...
  8. doi Quercetin and quercitrin protect against cytokine‑induced injuries in RINm5F β-cells via the mitochondrial pathway and NF-κB signaling
    Xiaoqian Dai
    Department of Nutrition and Food Hygiene, School of Public Health, Peking University Health Science Center, Haidian, Beijing 100191, PR China
    Int J Mol Med 31:265-71. 2013
    ....
  9. ncbi Improved radiation hybrid map of rat chromosome 2: colocalization of the genes encoding corticotropin-releasing hormone and IL6-receptor with quantitative trait loci regulating the inflammatory response
    J F Laes
    Universite Libre de Bruxelles, IBMM, Gosselies, Belgium
    Cytogenet Cell Genet 92:130-3. 2001
    ..Our data show that they reside within regions that were genetically defined as QTLs controlling the inflammatory response. These genes are thus both functional and positional candidates...
  10. ncbi Helicobacter pylori induces apoptosis of rat gastric parietal cells
    Bruno Neu
    Department of Medicine II, Technical University of Munich, Germany
    Am J Physiol Gastrointest Liver Physiol 283:G309-18. 2002
    ..In summary, cagE presence appears to be essential for H. pylori-induced apoptosis of gastric parietal cells, and this effect is dependent on the activation of NF-kappaB and production of nitric oxide...
  11. ncbi Gene transfer of truncated IkappaBalpha prevents tubulointerstitial injury
    Osamu Takase
    Department of Internal Medicine, Keio University Medical School, Tokyo, Japan
    Kidney Int 63:501-13. 2003
    ..We investigated the role of nuclear factor-kappaB (NF-kappaB) in tubular epithelial cells in the development of proteinuria-induced TI injury...
  12. ncbi Nuclear factor-kappaB represses hypoxia-induced mitochondrial defects and cell death of ventricular myocytes
    Kelly M Regula
    Institute of Cardiovascular Sciences, St Boniface General Hospital Research Centre, Department of Physiology, Faculty of Medicine University of Manitoba, Winnipeg, Manitoba, Canada
    Circulation 110:3795-802. 2004
    ..In the present study, we wished to ascertain whether activation of the cellular factor nuclear factor (NF)-kappaB suppresses mitochondrial defects and cell death of ventricular myocytes during hypoxic injury...
  13. ncbi Inhibition of NF-{kappa}B improves left ventricular remodeling and cardiac dysfunction after myocardial infarction
    Yasuyuki Onai
    Dept of Cardiovascular Medicine, Tokyo Medical and Dental Univ, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8519, Japan
    Am J Physiol Heart Circ Physiol 292:H530-8. 2007
    ..In conclusion, inhibition of NF-kappaB activation may reduce the proinflammatory reactions and modulate the extracellular matrix and provide an effective approach to prevent adverse cardiac remodeling after MI...
  14. pmc Differential transcriptional control of the superoxide dismutase-2 kappaB element in neurons and astrocytes
    Xianrong Mao
    Department of Geriatrics, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA
    J Biol Chem 281:35863-72. 2006
    ....
  15. ncbi Increased cyclooxygenase-2 expression in hypothalamic paraventricular nucleus in rats with heart failure: role of nuclear factor kappaB
    Yang Yu
    Department of Internal Medicine, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
    Hypertension 49:511-8. 2007
    ..By enhancing access of prostaglandin E2 to hypothalamic neurons, this mechanism may contribute to augmented sympathetic nerve activity in HF...
  16. doi NF-kappaB-dependent genes induced by proteinuria and identified using DNA microarrays
    Osamu Takase
    Department of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo, 160 8582, Japan
    Clin Exp Nephrol 12:181-8. 2008
    ..To explore the molecular mechanisms of the proteinuria-induced TI injury further, we have analyzed renal gene expression with DNA microarrays, with and without specific inhibition of NF-kappaB in the proximal tubules...
  17. doi Amitriptyline induces nuclear transcription factor-kappaB-dependent glutamate transporter upregulation in chronic morphine-infused rats
    Y H Tai
    Department of Anesthesiology, Tri Service General Hospital and National Defense Medical Center, Taipei, Taiwan
    Neuroscience 153:823-31. 2008
    ..The mechanism involves activation of the NF-kappaB pathway, but may also involve other pathways...
  18. doi Genomic analysis of sulfasalazine effect in experimental colitis is consistent primarily with the modulation of NF-kappaB but not PPAR-gamma signaling
    Olga Martínez-Augustin
    Department of Biochemistry and Molecular Biology, University of Granada, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas, Granada, Spain
    Pharmacogenet Genomics 19:363-72. 2009
    ..The objective of our study was to further characterize SAZ mechanism by studying its effect on the colonic transcriptome in a suitable preclinical model of inflammatory bowel disease...
  19. pmc Lipopolysaccharides up-regulate Kir6.1/SUR2B channel expression and enhance vascular KATP channel activity via NF-kappaB-dependent signaling
    Weiwei Shi
    Department of Biology, Georgia State University, Atlanta, Georgia 30303, USA
    J Biol Chem 285:3021-9. 2010
    ..1 and SUR2B expression to a similar degree as LPS. Thus, the effect of LPS on vasodilation involves up-regulation of K(ATP) channel expression, in which the NF-kappaB-dependent signaling plays an important role...
  20. doi Role of nuclear factor-κB in volatile anaesthetic preconditioning with sevoflurane during myocardial ischaemia/reperfusion
    Chen Wang
    Department of Anaesthesiology, the Second Affiliated Hospital of Soochow University, and Institute of Neuroscience, Soochow University, Suzhou, China
    Eur J Anaesthesiol 27:747-56. 2010
    ....
  21. ncbi [Effects of propofol on the activation of nuclear factor-kappaB and cardiomyocytes apoptosis during myocardial ischemia/reperfusion injury in rats]
    Song Zhao
    Hebei Medical University, Shijiazhuang 050017, China
    Zhongguo Ying Yong Sheng Li Xue Za Zhi 26:291-5. 2010
    ..To explore the molecular mechanisms of propofol in myocardial protection, the activation of nuclear factor-kappaB (NF-kappaB) and the apoptosis of cardiomyocytes were examined...
  22. doi Nuclear factor kappaB downregulates the transient outward potassium current I(to,f) through control of KChIP2 expression
    Brian K Panama
    DVM, 150 College St, Fitzgerald Bldg, Rm 68, Toronto, Ontario, Canada M5S 3E2
    Circ Res 108:537-43. 2011
    ..I(to,f) is consistently downregulated in cardiac disease. Despite its importance, the regulation of I(to,f) in disease remains poorly understood...
  23. pmc Epigenetic changes in mitochondrial superoxide dismutase in the retina and the development of diabetic retinopathy
    Qing Zhong
    Kresge Eye Institute, Wayne State University, Detroit, Michigan, USA
    Diabetes 60:1304-13. 2011
    ....
  24. doi Increased interactions between PKA and NF-κB signaling in the hippocampus following loss of cholinergic input
    C S Lim
    Blanchette Rockefeller Neurosciences Institute at West Virginia University, Morgantown, WV 26505, USA
    Neuroscience 192:485-93. 2011
    ..Such altered signaling may contribute to psychiatric symptoms, including depression, in patients with AD...
  25. doi A physiological concentration of glucocorticoid inhibits the pro-inflammatory cytokine-induced proliferation of adult rat cardiac fibroblasts: roles of extracellular signal-regulated kinase 1/2 and nuclear factor-κB
    Yan hua He
    Department of Pharmacology, Guangzhou Key Laboratory of Cardiovascular Disease and the Second Affiliated Hospital, Guangzhou Medical University, China
    Clin Exp Pharmacol Physiol 38:739-46. 2011
    ..4. In conclusion, the results of the present study indicate that a physiological concentration of hydrocortisone can inhibit inflammation-induced proliferation of cardiac fibroblasts by preventing the activation of ERK1/2 and NF-κB...
  26. doi Curcumin inhibits ox-LDL-induced MCP-1 expression by suppressing the p38MAPK and NF-κB pathways in rat vascular smooth muscle cells
    Yi Zhong
    Department of Cardiology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, People s Republic of China
    Inflamm Res 61:61-7. 2012
    ....
  27. doi Simultaneous blockade of the CD40/CD40L and NF-κB pathways prolonged islet allograft survival
    Xiao Hong Wang
    Department of Renal Transplant, Center of Nephropathy, The First Affiliated Hospital, Medical College, Xi an Jiaotong University, Xi an, Shanxi Province, China
    Transpl Int 25:118-26. 2012
    ..01). Simultaneous blockade of the CD40/CD40L and IκB/NF-κB pathways could effectively extend the survival of islet grafts...
  28. pmc Stretch-induced hypertrophy activates NFkB-mediated VEGF secretion in adult cardiomyocytes
    Anna Leychenko
    Department of Cell and Molecular Biology and Center for Cardiovascular Research, John A Burns School of Medicine, University of Hawaii, Honolulu, Hawaii, United States of America
    PLoS ONE 6:e29055. 2011
    ..Elucidation of this novel mechanism may provide a target for developing future pharmacotherapy to treat hypertension and heart disease...
  29. pmc Resveratrol, a polyphenol phytoalexin, protects cardiomyocytes against anoxia/reoxygenation injury via the TLR4/NF-κB signaling pathway
    Cui Zhang
    Department of Cardiology, Renmin Hospital of Wuhan University and Cardiovascular Research Institute of Wuhan University, Wuhan, PR China
    Int J Mol Med 29:557-63. 2012
    ..Treatment with resveratrol shortly after the onset of reoxygenation improves cell survival and attenuates A/R-induced inflammatory response. This protection mechanism is possibly related to the TLR4/NF-κB signaling pathway...
  30. doi β-Casomorphin-7 cause decreasing in oxidative stress and inhibiting NF-κB-iNOS-NO signal pathway in pancreas of diabetes rats
    Hong Yin
    Key Laboratory of Animal Physiology and Biochemistry, Nanjing Agricultural Univ, Nanjing 210095, PR China
    J Food Sci 77:C278-82. 2012
    ..Thus, the results of the present study suggest that β-CM-7 may cause protective effects such as pronounced decreasing in oxidative stress and inhibiting NF-κB-iNOS-NO signal pathway in pancreas of diabetes rats...
  31. pmc HGF and direct mesenchymal stem cells contact synergize to inhibit hepatic stellate cells activation through TLR4/NF-kB pathway
    Pei Pei Wang
    Department of Infectious Diseases, The Third Affiliated Hospital of Sun Yat Sen University, Guangzhou, Guangdong Province, China
    PLoS ONE 7:e43408. 2012
    ..The purpose of this study was to explore the underlying mechanisms by which BMSCs modulate the function of activated HSCs...
  32. doi Thyroid peroxidase gene expression is induced by lipopolysaccharide involving nuclear factor (NF)-κB p65 subunit phosphorylation
    Magalí Nazar
    Centro de Investigaciones en Bioquimica Clinica e Inmunologia, Consejo Nacional de Investigaciones Cientificas y Tecnicas, Departamento de Bioquimica Clinica, Facultad de Ciencias Quimicas, Universidad Nacional de Cordoba, 5000 Cordoba, Argentina
    Endocrinology 153:6114-25. 2012
    ..Our results provide new insights into the potential effects of infectious processes on thyroid homeostasis...
  33. pmc Using a novel in vivo model to study the function of nuclear factor kappa B in cerebral ischemic injury
    Rui Wang
    Department of Neurology, Second Affiliated Hospital of Harbin Medical University, Harbin, China
    Med Sci Monit 18:BR461-7. 2012
    ..Nuclear factor kappa B (NF-κB) plays an important role in inflammation and immune regulation. The aim of this study was to test the function of the activation of NF-κB in vivo in cerebral ischemic injury...
  34. pmc Quercetin protects rat dorsal root ganglion neurons against high glucose-induced injury in vitro through Nrf-2/HO-1 activation and NF-κB inhibition
    Yue Shi
    Department of Traditional Chinese Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China
    Acta Pharmacol Sin 34:1140-8. 2013
    ..To examine the effects of quercetin, a natural antioxidant, on high glucose (HG)-induced apoptosis of cultured dorsal root ganglion (DRG) neurons of rats...
  35. pmc Modulation of pineal melatonin synthesis by glutamate involves paracrine interactions between pinealocytes and astrocytes through NF-κB activation
    Darine Villela
    Laboratory of Pharmacology, Butantan Institute, Avenida Vital Brasil 1500, 05503 900 Sao Paulo, SP, Brazil
    Biomed Res Int 2013:618432. 2013
    ....
  36. pmc In vivo transfection of manganese superoxide dismutase gene or nuclear factor κB shRNA in nodose ganglia improves aortic baroreceptor function in heart failure rats
    Dongze Zhang
    Department of Emergency Medicine, University of Nebraska Medical Center, 985850 Nebraska Medical Center, Omaha, NE 68198 5850
    Hypertension 63:88-95. 2014
    ..The present study suggests that superoxide-NFκB signaling contributes to CHF-induced baroreceptor dysfunction and resultant impairment of baroreflex function. ..
  37. pmc Activation of NF-κB mediates astrocyte swelling and brain edema in traumatic brain injury
    Arumugam R Jayakumar
    1 Department of Pathology, University of Miami School of Medicine and Veterans Affairs Medical Center, Miami, Florida
    J Neurotrauma 31:1249-57. 2014
    ..Our findings strongly suggest that activation of astrocytic NF-κB represents a key element in the process by which cytotoxic brain edema occurs after TBI...
  38. doi Curcumol induces HSC-T6 cell death through suppression of Bcl-2: involvement of PI3K and NF-κB pathways
    Gang Chen
    The Institute of Medicine, Qiqihar Medical University, 333 BuKui Street, JianHua District, Qiqihar 161006, China
    Eur J Pharm Sci 65:21-8. 2014
    ..Thus, our study indicates that curcumol is a potential candidate for further preclinical study aimed at the treatment of liver fibrosis. ..
  39. doi Toll-like receptor 4-mediated nuclear factor-κB activation in spinal cord contributes to chronic morphine-induced analgesic tolerance and hyperalgesia in rats
    Liying Bai
    Department of Anesthesiology, The First Affiliated Hospital, Zhengzhou University, Zhengzhou, 450052, China
    Neurosci Bull 30:936-48. 2014
    ..These data indicated that TLR4-mediated NF-κB activation in the spinal cord is involved in the development and maintenance of morphine analgesic tolerance and withdrawal-induced pain hypersensitivity...
  40. pmc Autophagy attenuates the catabolic effect during inflammatory conditions in nucleus pulposus cells, as sustained by NF-κB and JNK inhibition
    Kang Xu
    Experimental Center of the Surgery, Sun Yat Sen Memorial Hospital, Sun Yat Sen University, Guangzhou, Guangdong 510120, P R China
    Int J Mol Med 36:661-8. 2015
    ..Finally, IKKβ knockdown was used to further confirm the effect of the NF‑κB signal on human NP cells autophagy, and the data showed that IKKβ knockdown upregulated the autophagy of NP cells during inflammatory conditions...
  41. doi NF-κB Signaling is Involved in the Effects of Intranasally Engrafted Human Neural Stem Cells on Neurofunctional Improvements in Neonatal Rat Hypoxic-Ischemic Encephalopathy
    Gang Ji
    State Key Laboratory of Medical Neurobiology, School of Basic Medical Sciences, Shanghai Medical College, Fudan University, Shanghai, China
    CNS Neurosci Ther 21:926-35. 2015
    ..The current study investigated the efficacy and molecular events of human embryonic neural stem cells (hNSCs) in neonatal hypoxic-ischemic (HI) rats...
  42. ncbi Mutation analysis and association studies of nuclear factor-kappaB1 in sporadic Parkinson's disease patients
    P Wintermeyer
    Department of Molecular Human Genetics, Children s Hospital, University of Rostock, Federal Republic of Germany
    J Neural Transm (Vienna) 109:1181-8. 2002
    ..We performed a detailed mutation analysis of the p50 subunit of NF-kappaB (NFKB1 gene) in 96 sporadic PD patients...
  43. pmc Anti-inflammatory effect of Diammonium Glycyrrhizinate in a rat model of ulcerative colitis
    Hao Yuan
    Department of Internal Medicine, Weifang Medical College, Weifang 261042, Shandong Province, China
    World J Gastroenterol 12:4578-81. 2006
    ..To explore the anti-inflammatory mechanism of Diammonium Glycyrrhizinate in a rat model of ulcerative colitis induced by acetic acid...
  44. ncbi Lipopolysaccharide-induced decreased protein S expression in liver cells is mediated by MEK/ERK signaling and NFkappaB activation: involvement of membrane-bound CD14 and toll-like receptor-4
    T Hayashi
    Department of Molecular Pathobiology, Mie University Graduate School of Medicine, Mie, Japan
    J Thromb Haemost 4:1763-73. 2006
    ..The decreased plasma level of PS in sepsis is associated with thrombotic tendency, but the mechanism is unclear...
  45. ncbi [Expression of NF-kappaB and TNF-alpha in spinal dorsal horn in a rat model of neuropathic pain]
    Li Zhang
    Department of Pain Management, Provincial Hospital affiliated to Shandong University, Jinan, China
    Zhonghua Yi Xue Za Zhi 90:1067-71. 2010
    ..To investigate the expressions of NF-kappaB and TNF-alpha in lumbar spinal cord in a rat model of chronic constrictive injury (CCI)...
  46. ncbi [Dual role of NF-κB and its target gene iNOS in cerebral ischemic tolerance induced by focal ischemic preconditioning]
    Yu man Hao
    Department of Neurology, Second Affiliated Clinical College in Chengdu, Chongqing Medical University, Third People s Hospital of Chengdu, Chengdu 610031, China
    Zhonghua Yi Xue Za Zhi 90:2787-91. 2010
    ..To investigate the effect of focal cerebral ischemic preconditioning on the expression of nuclear factor kappa B (NF-κB) and its target gene inducible nitric oxide synthase (iNOS) and to explore its role in ischemic tolerance in rats...
  47. pmc Nuclear factor kappa B and matrix metalloproteinase induced receptor cleavage in the spontaneously hypertensive rat
    Kwan I Sharon Wu
    Department of Bioengineering, Institute for Engineering in Medicine, University of California San Diego, La Jolla, CA 92093 0412, USA
    Hypertension 57:261-8. 2011
    ..These results suggest NFκB is an important transcription factor in the SHR and may be involved in the enhanced MMP activity and, consequently, receptor cleavage...
  48. doi Nuclear factor-kappa B mediates TRPV4-NO pathway involved in thermal hyperalgesia following chronic compression of the dorsal root ganglion in rats
    Chao Wang
    Department of Physical Medicine and Rehabilitation, Qilu Hospital, Medical School of Shandong University, Jinan 250012, China
    Behav Brain Res 221:19-24. 2011
    ..In conclusion, our data suggested that NF-κB could be involved in TRPV4-NO pathway in CCD-induced thermal hyperalgesia...
  49. ncbi [Change of nuclear factor-kappaB activity in early burn injury and its significance]
    Jian kun Liao
    Emergency Department, Guangdong Provincial Crops Hospital, Chinese People s Armed Police Forces, Guangzhou 510507, Guangdong, China
    Zhongguo Wei Zhong Bing Ji Jiu Yi Xue 15:220-1. 2003
    ..To study the change of nuclear factor-kappaB(NF-kappaB) activity in the blood leukocytes of rats in the early period after severe burn injury and its significance...
  50. ncbi [The effects of chronic hypoxic hypercapnia on the TLR4 and NFkappaB in hippocampus neuron in rats]
    Yong Li
    Department of Neurology, the Second Affiliated Hospital of Wenzhou Medical College, Wenzhou 325027, China
    Zhongguo Ying Yong Sheng Li Xue Za Zhi 25:27-30. 2009
    ..To study the expression and effect of TLR4 and NFkappaB protein in hippocampus neuron in rats exposed to chronic hypoxic hypercapnia...
  51. ncbi [Mechanism of the reduction of cerebral ischemic-reperfusion injury through inhibiting the activity of NF-kappaB by propyl gallate]
    Jian ming Zheng
    Department of Neurology, the Affiliated Union Hospital of Fujian Medical University, Fuzhou 350001, China
    Yao Xue Xue Bao 46:158-64. 2011
    ..It also could influence HSP70 and TLR-4...
  52. doi Hydroquinone stimulates inflammatory functions in microvascular endothelial cells via NF-κB nuclear activation
    Cristina Bichels Hebeda
    Department of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences, University of Sao Paulo, Sao Paulo, Brazil
    Basic Clin Pharmacol Toxicol 109:372-80. 2011
    ..Taken together, the data herein presented reveal that hydroquinone evokes pro-inflammatory properties in endothelial cells that are triggered by the enhancement of NF-κB nuclear translocation-dependent gene transcription...
  53. doi Triptolide down-regulates COX-2 expression and PGE2 release by suppressing the activity of NF-κB and MAP kinases in lipopolysaccharide-treated PC12 cells
    Yu Geng
    Department of Neurology, Zhejiang Province People s Hospital, Hangzhou, China
    Phytother Res 26:337-43. 2012
    ..This suggests that the neuroprotective effects of TP may be partially mediated by direct inhibition of the expression of COX-2, activation of NF-κB, and phosphorylation of p38, ERK1/2 (p42/p44) and AKT proteins of neuronal cells...
  54. doi Vitexin protects against myocardial ischemia/reperfusion injury in Langendorff-perfused rat hearts by attenuating inflammatory response and apoptosis
    Liuyi Dong
    Department of Pharmacology, Anhui Medical University, Hefei, Anhui 230032, PR China
    Food Chem Toxicol 49:3211-6. 2011
    ....
  55. doi Ischemic preconditioning protects against myocardial ischemia-reperfusion injury through inhibiting toll-like receptor 4/NF-κB signaling pathway in rats
    Jing Yang
    Department of Pharmacology, Central South University, Changsha 410078, China
    Zhong Nan Da Xue Xue Bao Yi Xue Ban 36:972-8. 2011
    ....
  56. pmc Lactobacillus reuteri strains reduce incidence and severity of experimental necrotizing enterocolitis via modulation of TLR4 and NF-κB signaling in the intestine
    Yuying Liu
    Department of Pediatrics, Division of Gastroenterology, University of Texas Health Science Center at Houston Medical School, USA
    Am J Physiol Gastrointest Liver Physiol 302:G608-17. 2012
    ..reuteri strains has potential therapeutic value in our NEC model and in enteritis associated with cow milk feeding. These results support the concept that L. reuteri may represent a valuable treatment to prevent NEC...
  57. pmc Interleukin-1β modulates smooth muscle cell phenotype to a distinct inflammatory state relative to PDGF-DD via NF-κB-dependent mechanisms
    Matthew R Alexander
    Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, Virginia, USA
    Physiol Genomics 44:417-29. 2012
    ..In addition, studies provide evidence for the possible utility of CCL20 and RGS17 as markers of inflammatory and proliferative state SMCs within atherosclerotic plaques in vivo...
  58. doi Ginkgolide B reduces neuronal cell apoptosis in the traumatic rat brain: possible involvement of toll-like receptor 4 and nuclear factor kappa B pathway
    Wen Hua Yu
    Department of Neurosurgery, First Hangzhou Municipal People s Hospital, Nanjing Medical University, Hangzhou 310000, China
    Phytother Res 26:1838-44. 2012
    ..Thus, GB may inhibit TLR-4 and NF-κB-dependent inflammatory responses, and furthermore lessen neuronal cell apoptosis after TBI, which may support the use of GB for the treatment of TBI...
  59. doi Differential usage of NF-κB activating signals by IL-1β and TNF-α in pancreatic beta cells
    F Ortis
    Laboratory of Experimental Medicine, Universite Libre de Bruxelles, Brussels, Belgium
    FEBS Lett 586:984-9. 2012
    ..Both IKKγ and activation of the TRAF6-TAK1-JNK pathway are involved in IL-1β-induced IKKβ degradation...
  60. pmc Hyperglycemia exacerbates burn-induced liver inflammation via noncanonical nuclear factor-κB pathway activation
    Gabriela A Kulp
    Department of Ophthalmology and Visual Sciences, University of Texas Medical Branch, Galveston, Texas, United States of America
    Mol Med 18:948-56. 2012
    ..Hyperglycemia is detrimental to burn outcome by augmenting inflammation mediated by hepatic noncanonical NF-κB pathway activation...
  61. doi Hypercapnic acidosis attenuates ventilation-induced lung injury by a nuclear factor-κB-dependent mechanism
    Maya Contreras
    School of Medicine, Clinical Sciences Institute, National University of Ireland, Galway, Ireland
    Crit Care Med 40:2622-30. 2012
    ..We wished to determine whether the beneficial effects of hypercapnic acidosis in reducing stretch-induced injury were mediated via inhibition of nuclear factor-κB, a key transcriptional regulator in inflammation, injury, and repair...
  62. pmc NF-kB overexpression and decreased immunoexpression of AR in the muscular layer is related to structural damages and apoptosis in cimetidine-treated rat vas deferens
    Juliana Y Koshimizu
    Department of Morphology, Laboratory of Histology and Embryology, Araraquara Dental School UNESP Univ, Estadual Paulista, Brazil
    Reprod Biol Endocrinol 11:29. 2013
    ..Either androgen or histamine H2 receptors have been detected in the mucosa and smooth muscular layer of vas deferens. Thus, the effect of cimetidine on this androgen and histamine-dependent muscular duct was morphologically evaluated...
  63. ncbi Hypoosmolarity influences the activity of transcription factor NF-kappaB in rat H4IIE hepatoma cells
    M Michalke
    Department of Gastroenterology, Hepatology and Infectiology, Heinrich Heine University, Moorenstr 5, D 40225, D usseldorf, Germany
    FEBS Lett 465:64-8. 2000
    ..Transforming growth factor beta-induced apoptosis was diminished by hypoosmolarity. However, this anti-apoptotic effect was probably not related to NF-kappaB activation...
  64. ncbi Temporal control of NF-kappaB activation by ERK differentially regulates interleukin-1beta-induced gene expression
    Bingbing Jiang
    Whitaker Cardiovascular Institute, Department of Medicine, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Biol Chem 279:1323-9. 2004
    ..These results reveal a novel functional role for ERK as an important temporal regulator of NF-kappaB activation and NF-kappaB-dependent gene expression...
  65. ncbi Induction of myofibroblast MMP-9 transcription in three-dimensional collagen I gel cultures: regulation by NF-kappaB, AP-1 and Sp1
    Terumi Takahra
    Third Department of Internal Medicine, Toyama Medical and Pharmaceutical University, 2630 Sugitani, 930 0194, Toyama, Japan
    Int J Biochem Cell Biol 36:353-63. 2004
    ..It is concluded that 3D contact of activated HSC with collagen I stimulates MMP-9 expression by elevating NF-kappaB and AP-1 activities which are able to overcome the repressive influence of Sp1/Sp3 on MMP-9 gene transcription...
  66. ncbi Inhibition of experimental abdominal aortic aneurysm in the rat by use of decoy oligodeoxynucleotides suppressing activity of nuclear factor kappaB and ets transcription factors
    Hideki Nakashima
    Division of Clinical Gene Therapy, Graduate School of Medicine, Osaka University, 2 2 Yamada oka, Suita, Osaka 565 0871, Japan
    Circulation 109:132-8. 2004
    ..Thus, we developed a novel strategy to treat AAA by simultaneous inhibition of both NF-kappaB and ets by using chimeric decoy oligodeoxynucleotides (ODN)...
  67. ncbi Kupffer cell stimulation in the isolated perfused rat liver triggers nuclear factor-kappaB DNA binding activity
    Pamela Romanque
    Programa de Farmacología Molecular y Clínica, Instituto de Ciencias Biomedicas, Facultad de Medicina, Universidad de Chile, Santiago, Chile
    Redox Rep 8:341-6. 2003
    ....
  68. ncbi Role of NF-kappaB and DNA repair protein Ku on apoptosis in pancreatic acinar cells
    Ji Yeon Song
    Department of Pharmacology and Institute of Gastroenterology, Brain Korea 21 Project for Medical Science, Yonsei University College of Medicine, Seoul 120 752, Korea
    Ann N Y Acad Sci 1010:259-63. 2003
    ..The novel finding is that nuclear translocation of Ku proteins may be mediated by NF-kappaB...
  69. ncbi Hypoxic suppression of E. coli-induced NF-kappa B and AP-1 transactivation by oxyradical signaling
    George M Matuschak
    Division of Pulmonary, Critical Care, and Occupational Medicine, Department of Internal Medicine, St Louis University School of Medicine, and Department of Critical Care Medicine, St John s Mercy Medical Center, St Louis, Missouri, USA
    Am J Physiol Regul Integr Comp Physiol 287:R437-45. 2004
    ..These results suggest a novel multifunctionality of oxyradicals in decoupling hepatic transcriptional activity and cytokine biosynthesis early in the posttraumatic milieu...
  70. pmc Prolongation of liver allograft survival by dendritic cells modified with NF-kappaB decoy oligodeoxynucleotides
    Ming Qing Xu
    Department of General Surgery, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China
    World J Gastroenterol 10:2361-8. 2004
    ..To induce the tolerance of rat liver allograft by dendritic cells (DCs) modified with NF-kappaB decoy oligodeoxynucleotides (ODNs)...
  71. ncbi Alpha-melanocyte stimulating hormone protects against H2O2-induced inhibition of wound restitution in IEC-6 cells via a Syk kinase- and NF-kappabeta-dependent mechanism
    Lei Zou
    Department of Internal Medicine, Trauma Research Center, University of Texas Medical School at Houston, Houston, Texas, USA
    Shock 22:453-9. 2004
    ..The data also disclose that the beneficial effects of alpha-MSH on gut ischemia/reperfusion injury may relate to its acceleration of epithelial restitution...
  72. ncbi The effect of hindlimb immobilization on acid phosphatase, metalloproteinases and nuclear factor-kappaB in muscles of young and old rats
    Marina Bar-Shai
    Department of Anatomy and Cell Biology, Bruce Rappaport Faculty of Medicine, Technion Israel Institute of Technology, P O Box 9649, Haifa 31096, Israel
    Mech Ageing Dev 126:289-97. 2005
    ..In conclusion, it seems that the kinetics of activation of extracellular hydrolytic and proteolytic systems differ in muscles of old animals compared to young animals...
  73. ncbi In vivo heat shock protein assembles with septic liver NF-kappaB/I-kappaB complex regulating NF-kappaB activity
    Hsiang Wen Chen
    Department of Microbiology, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung City, Taiwan
    Shock 24:232-8. 2005
    ..HSP72 appears to play a crucial protective role in modulating the gene expression controlled by NF-kappaB in sepsis...
  74. ncbi SIRT1 protects against microglia-dependent amyloid-beta toxicity through inhibiting NF-kappaB signaling
    Jennifer Chen
    Gladstone Institute of Neurological Disease, University of California, San Francisco, California 94158, USA
    J Biol Chem 280:40364-74. 2005
    ..They also implicate SIRT1 in this pathway and highlight the therapeutic potential of resveratrol and other sirtuin-activating compounds in Alzheimer disease...
  75. ncbi Inflammatory cytokines induce production of CHI3L1 by articular chondrocytes
    Anneliese D Recklies
    Joint Diseases Laboratory, Shriners Hospital for Children, McGill University, Montreal, Quebec, Canada
    J Biol Chem 280:41213-21. 2005
    ....
  76. ncbi [Effects of moderate hypothermia on expression of nuclear factor-KappaB in rats with acute pancreatitis]
    Xue min Wang
    Shanghai Sixth People s Hospital, Medical College of Shanghai Jiao Tong University, Shanghai 200233, China
    Zhongguo Wei Zhong Bing Ji Jiu Yi Xue 17:658-61. 2005
    ....
  77. ncbi [Relationship between nuclear factor-kappaB activity and kidney injury in rats with postburn sepsis]
    Feng hua Yao
    Department of Nephrology, 304 th Hospital Affiliated to General Hospital of PLA, Beijing 100037, China
    Zhongguo Wei Zhong Bing Ji Jiu Yi Xue 17:722-5. 2005
    ..To investigate the relationship between nuclear factor-KappaB (NF-KappaB) activity and kidney injury in rats with postburn sepsis...
  78. pmc Effect of nuclear factor kappa B on intercellular adhesion molecule-1 expression and neutrophil infiltration in lung injury induced by intestinal ischemia/reperfusion in rats
    Xiao Feng Tian
    Department of General Surgery, Second Affiliated Hospital, Dalian Medical University, Dalian 116027, Liaoning Province, China
    World J Gastroenterol 12:388-92. 2006
    ....
  79. ncbi Ethanol sensitizes NF-kappaB activation in pancreatic acinar cells through effects on protein kinase C-epsilon
    Akihiko Satoh
    VA Greater L A Healthcare System, West L A Healthcare Center, Bldg 258, RM 340, 11301 Wilshire Blvd, Los Angeles, CA 90073, USA
    Am J Physiol Gastrointest Liver Physiol 291:G432-8. 2006
    ..These results suggest that ethanol enhances the CCK-8-induced NF-kappaB activation at least in part through its effects on PKC-epsilon...
  80. ncbi Peroxynitrite induces an alternative NF-kappaB activation pathway in L8 rat myoblasts
    Marina Bar-Shai
    Department of Anatomy and Cell Biology, Rappaport Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel
    Antioxid Redox Signal 8:639-52. 2006
    ..This resulted in prolonged iNOS expression. Hence, peroxynitrite may exacerbate inflammatory responses mediated by NF-kappaB...
  81. ncbi Hypoxia/reoxygenation differentially modulates NF-kappaB activation and iNOS expression in astrocytes and microglia
    Guiwen Guo
    Department of Neurology, Medical University of South Carolina, Charleston, 29425, USA
    Antioxid Redox Signal 8:911-8. 2006
    ..Lastly, the two cell types displayed differential vulnerabilities to hypoxia-induced cell death, the astrocytes being relatively more resistant than microglia...
  82. ncbi Angiotensin II and Aldosterone stimulating NF-kappaB and AP-1 activation in hepatic fibrosis of rat
    Xu Li
    Department of Emergency, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China
    Regul Pept 138:15-25. 2007
    ..The present study aims to investigate the signal transduction mechanism underlying effects of Ang II and Aldo on NF-kappaB and AP-1 pathway during hepatic fibrogenesis...
  83. ncbi Action of NF-kappaB on the delta opioid receptor gene promoter
    Yulong L Chen
    Department of Pharmacology, University of Minnesota Medical School, Minneapolis, MN 55455, USA
    Biochem Biophys Res Commun 352:818-22. 2007
    ..Together, the results show that direct association of p65 with the promoter is important in NGF-induced dor promoter activity...
  84. ncbi Transcriptional regulation of intronic calcium-activated potassium channel SK2 promoters by nuclear factor-kappa B and glucocorticoids
    Min Jeong Kye
    Department of Molecular Neuroendocrinology, Max Planck Institute for Experimental Medicine, Goettingen, Germany
    Mol Cell Biochem 300:9-17. 2007
    ..These findings suggest a possible transcriptional cross talk between GRs and NF-kappaB in the intronic promoter regulation of SK2-S channel gene transcription...
  85. ncbi Differential expression of genes involved with apoptosis, cell cycle, connective tissue proteins, fuel substrate utilization, inflammation and mitochondrial biogenesis in copper-deficient rat hearts: implication of a role for Nfkappab1
    Darcey Klaahsen
    Department of Human Nutrition, Kansas State University, Manhattan, KS 66506, USA
    J Nutr Biochem 18:719-26. 2007
    ..The results of this study merit the further investigation of the role of reactive oxidative species with regard to Nfkappab1 in the copper deficient rat heart...
  86. ncbi Inhibition of GSK-3beta decreases NF-kappaB-dependent gene expression and impairs the rat liver regeneration
    Huan Chen
    Clinical Research Center, Changhai Hospital, Shanghai 200433, China
    J Cell Biochem 102:1281-9. 2007
    ..GSK-3beta plays an important role in rat liver regeneration. We conclude it may partially result from the inhibition of the NF-kappaB pathway and enhancement of p21 (WAF1/Cip1) expression...
  87. ncbi Arginine vasopressin increases iNOS-NO system activity in cardiac fibroblasts through NF-kappaB activation and its relation with myocardial fibrosis
    Yan Hong Fan
    Department of Cardiology, Xijing Hospital, The Fourth Military Medical University, 17 Changlexi Street, Xi an 710032, PR China
    Life Sci 81:327-35. 2007
    ..NO production induced by AVP may counteract the profibrotic effects of AVP, thus the development of MF perhaps depends on the balance between profibrotic AVP and antifibrotic NO effects on MF...
  88. ncbi HB-EGF induces delayed STAT3 activation via NF-kappaB mediated IL-6 secretion in vascular smooth muscle cell
    Kuy Sook Lee
    Center for Biomedical Sciences, Division of Cardiovascular Diseases, National Institute of Health, Seoul, Korea
    Biochim Biophys Acta 1773:1637-44. 2007
    ..In conclusion, IL-6 plays an important role in the delayed activation of STAT3 and VSMC proliferation induced by HB-EGF...
  89. ncbi The classical and a non-classical pathways associated with NF-kappaB are involved in estrogen-mediated regulation of calbindin-D9k gene in rat pituitary cells
    Geun Shik Lee
    Laboratory of Veterinary Biochemistry and Molecular Biology, College of Veterinary Medicine, Chungbuk National University, Cheongju, Chungbuk 361 763, Republic of Korea
    Mol Cell Endocrinol 277:42-50. 2007
    ..Taken together, these results suggest that in GH3 cells, both the classical ERalpha-ERE pathway and a non-classical pathway involving NF-kappaB are involved in E2-mediatd regulation of CaBP-9k expression in the pituitary gland...
  90. pmc Biomechanical signals inhibit IKK activity to attenuate NF-kappaB transcription activity in inflamed chondrocytes
    Anar Dossumbekova
    The Ohio State University, Columbus, OH 43210, USA
    Arthritis Rheum 56:3284-96. 2007
    ..This study was undertaken to examine the intracellular mechanisms by which biomechanical signals suppress proinflammatory gene induction by the interleukin-1-beta (IL-1beta)-induced NF-kappaB signaling cascade in articular chondrocytes...
  91. ncbi Flavonoids protect against cytokine-induced pancreatic beta-cell damage through suppression of nuclear factor kappaB activation
    Eun Kyung Kim
    Department of Biochemistry, Chonbuk National University Medical School, Jeonju, South Korea
    Pancreas 35:e1-9. 2007
    ..Our current study focuses on the preventive effects of quercetin, apigenin, and luteolin on cytokine-induced beta-cell damage...
  92. pmc Progesterone prevents traumatic brain injury-induced intestinal nuclear factor kappa B activation and proinflammatory cytokines expression in male rats
    Gang Chen
    Department of Neurosurgery, Jinling Hospital, School of Medicine, Nanjing University, Nanjing, Jiangsu Province 210002, China
    Mediators Inflamm 2007:93431. 2007
    ..The results of the present study suggest that the therapeutic benefit of post-TBI progesterone injections might be due to its inhibitory effects on intestinal NF-kappaB activation and proinflammatory cytokines expression...
  93. doi Relationship between carbachol hyperstimulation-induced pancreatic intracellular trypsinogen and NF-kappa B activation in rats in vitro
    Chunfang Jiang
    Department of Emergency Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China
    J Huazhong Univ Sci Technolog Med Sci 28:69-72. 2008
    ..NF-kappa B activation is likely not necessary for high concentrations of carbachol-induced trypsinogen activation in pancreatic acinar cells in vitro...
  94. doi Strong neuroprotection by inhibition of NF-kappaB after neonatal hypoxia-ischemia involves apoptotic mechanisms but is independent of cytokines
    Cora H A Nijboer
    University Medical Center Utrecht, Laboratory of Psychoneuroimmunology, Lundlaan 6, KC 03 068 0, 3584 EA Utrecht, The Netherlands
    Stroke 39:2129-37. 2008
    ....
  95. pmc Cross-talk between cytokines and renin-angiotensin in hypothalamic paraventricular nucleus in heart failure: role of nuclear factor-kappaB
    Yu Ming Kang
    Shanxi Medical University, Taiyuan 030001, People s Republic of China
    Cardiovasc Res 79:671-8. 2008
    ....
  96. ncbi Serum levels of NFkappaB and pro-inflammatory cytokines following administration of mucotoxic drugs
    Richard M Logan
    Oral Pathology, School of Dentistry, Faculty of Health Sciences, The University of Adelaide, South Australia, Australia
    Cancer Biol Ther 7:1139-45. 2008
    ..The aims of this study were to determine whether changes in serum levels of NFkappaB, TNF, IL-1beta and IL-6 following administration of different drugs predicted histological evidence of tissue damage...
  97. doi NF-kappaB inhibits sodium transport via down-regulation of SGK1 in renal collecting duct principal cells
    Sophie de Seigneux
    Service de Nephrologie, Fondation pour Recherches Medicales, 64 Avenue de la Roseraie, 1211 Geneva 4, Switzerland
    J Biol Chem 283:25671-81. 2008
    ..In conclusion, we show that activation of the NF-kappaB pathway down-regulates SGK1 expression, which might lead to decreased ENaC alpha-subunit expression, ultimately resulting in decreased Na(+) transport...
  98. doi Pregabalin and gabapentin inhibit substance P-induced NF-kappaB activation in neuroblastoma and glioma cells
    Seyeon Park
    Dongduk Women s University, Department of Applied Chemistry, Seoul, Korea
    J Cell Biochem 105:414-23. 2008
    ..These results suggest a previously undefined role of pregabalin and gabapentin in the regulation of inflammation-related intracellular signaling in both neuronal and glial cells...
  99. pmc Age-related differences in NFkappaB translocation and Bcl-2/Bax ratio caused by TNFalpha and Abeta42 promote survival in middle-age neurons and death in old neurons
    Jigisha R Patel
    Department of Medical Microbiology, Immunology, and Cell Biology, Southern Illinois University, School of Medicine, Springfield, IL, USA
    Exp Neurol 213:93-100. 2008
    ..In the setting of old neurons, these results suggest that overactivated nuclear translocation of NFkappaB and lower Bcl-2 levels promote death that is reduced by inhibition of either TNFR1 or R2...
  100. pmc Diabetes-induced atrophy is associated with a muscle-specific alteration in NF-kappaB activation and expression
    Bruce C Frier
    School of Kinesiology, Faculty of Health Sciences, Research Institute, University of Western Ontario, London, Ontario, Canada
    Cell Stress Chaperones 13:287-96. 2008
    ..These results indicate that diabetes may alter NF-kappaB activity and expression in a muscle-specific manner...
  101. doi Hemolysate-induced expression of intercellular adhesion molecule-1 and monocyte chemoattractant protein-1 expression in cultured brain microvascular endothelial cells via through ROS-dependent NF-kappaB pathways
    Hua Lu
    Department of Neurosurgery, Jinling Hospital, Clinical School of Nanjing University, Nanjing, China
    Cell Mol Neurobiol 29:87-95. 2009
    ..Taken together, our results indicate that hemolysate can induce inflammatory responses that increase expression of ICAM-1 and MCP-1, through ROS-dependent NF-kappaB activation in BMECs...

Research Grants4

  1. LIVER/LUNG INTERACTIONS DURING GRAM NEGATIVE ENDOTOXEMIA
    George Matuschak; Fiscal Year: 2003
    ....
  2. MMP-9-Dependent Vessel Wall Remodeling is NO-Dependent
    Gilbert Upchurch; Fiscal Year: 2005
    ....
  3. Chronic Alcohol Consumption Induces Tumor Angiogenesis
    Jian Wei Gu; Fiscal Year: 2006
    ..The new information will promote cancer prevention and treatment. ..
  4. Role of CCK Receptor in Acute Pancreatitis Pathogenesis
    Isaac Samuel; Fiscal Year: 2007
    ..James W. Maher, MD, Director, Division of Gastrointestinal Surgery, University of Iowa College of Medicine, Iowa City. [] PHS 398/2590 (Rev. 05/01) Page__ 26 Continuation Format Page [] ..