Nfe2l2

Summary

Gene Symbol: Nfe2l2
Description: nuclear factor, erythroid 2-like 2
Alias: nuclear factor erythroid 2-related factor 2, NF-E2-related factor 2, NFE2-related factor 2, nrf2, nuclear factor, erythroid derived 2, like 2
Species: rat

Top Publications

  1. ncbi Keap1-dependent proteasomal degradation of transcription factor Nrf2 contributes to the negative regulation of antioxidant response element-driven gene expression
    Michael McMahon
    Biomedical Research Centre, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, Scotland, United Kingdom
    J Biol Chem 278:21592-600. 2003
  2. ncbi Nrf2 controls constitutive and inducible expression of ARE-driven genes through a dynamic pathway involving nucleocytoplasmic shuttling by Keap1
    Truyen Nguyen
    Schering Plough Research Institute, Kenilworth, New Jersey 07033, USA
    J Biol Chem 280:32485-92. 2005
  3. ncbi Peroxynitrite induces HO-1 expression via PI3K/Akt-dependent activation of NF-E2-related factor 2 in PC12 cells
    Mei Hua Li
    National Research Laboratory, College of Pharmacy, Seoul National University, Shinlim Dong, Kwanak Ku, Seoul 151 742, South Korea
    Free Radic Biol Med 41:1079-91. 2006
  4. doi Nrf2-dependent upregulation of antioxidative enzymes: a novel pathway for proteasome inhibitor-mediated cardioprotection
    Henryk Dreger
    Medizinische Klinik für Kardiologie und Angiologie, Campus Mitte, Charite Universitatsmedizin Berlin, Chariteplatz 1, D 10117 Berlin, Germany
    Cardiovasc Res 83:354-61. 2009
  5. doi Curcumin upregulates transcription factor Nrf2, HO-1 expression and protects rat brains against focal ischemia
    Chenhui Yang
    Department of Neurology, Second Hospital of Hebei Medical University, Shijiazhuang 050000, China
    Brain Res 1282:133-41. 2009
  6. doi Cyclo(His-Pro) up-regulates heme oxygenase 1 via activation of Nrf2-ARE signalling
    Alba Minelli
    Dipartimento Medicina Sperimentale Scienze Biochimiche, Sezione Biochimica Cellulare, Universita di Perugia, Perugia, Italia
    J Neurochem 111:956-66. 2009
  7. doi Contribution of impaired Nrf2-Keap1 pathway to oxidative stress and inflammation in chronic renal failure
    Hyun Ju Kim
    Division of Nephrology and Hypertension, University of California, Irvine, California, USA
    Am J Physiol Renal Physiol 298:F662-71. 2010
  8. doi After cellular internalization, quercetin causes Nrf2 nuclear translocation, increases glutathione levels, and prevents neuronal death against an oxidative insult
    Florencia Arredondo
    Departamento de Neuroquimica, Instituto de Investigaciones Biologicas Clemente Estable, 11600 Montevideo, Uruguay
    Free Radic Biol Med 49:738-47. 2010
  9. doi Resveratrol protects diabetic kidney by attenuating hyperglycemia-mediated oxidative stress and renal inflammatory cytokines via Nrf2-Keap1 signaling
    P Palsamy
    Department of Biochemistry, University of Madras, Guindy Campus, Chennai, 600 025 Tamilnadu, India
    Biochim Biophys Acta 1812:719-31. 2011
  10. pmc Induction of NAD(P)H-quinone oxidoreductase 1 by antioxidants in female ACI rats is associated with decrease in oxidative DNA damage and inhibition of estrogen-induced breast cancer
    Bhupendra Singh
    Division of Pharmacology and Toxicology, School of Pharmacy, University of Missouri Kansas City, Kansas City, MO 64108, USA
    Carcinogenesis 33:156-63. 2012

Scientific Experts

Detail Information

Publications119 found, 100 shown here

  1. ncbi Keap1-dependent proteasomal degradation of transcription factor Nrf2 contributes to the negative regulation of antioxidant response element-driven gene expression
    Michael McMahon
    Biomedical Research Centre, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, Scotland, United Kingdom
    J Biol Chem 278:21592-600. 2003
    Keap1 is a negative regulator of Nrf2, a bZIP transcription factor that mediates adaptation to oxidative stress...
  2. ncbi Nrf2 controls constitutive and inducible expression of ARE-driven genes through a dynamic pathway involving nucleocytoplasmic shuttling by Keap1
    Truyen Nguyen
    Schering Plough Research Institute, Kenilworth, New Jersey 07033, USA
    J Biol Chem 280:32485-92. 2005
    b>Nrf2 regulates the expression of genes encoding antioxidant proteins involved in cellular redox homeostasis...
  3. ncbi Peroxynitrite induces HO-1 expression via PI3K/Akt-dependent activation of NF-E2-related factor 2 in PC12 cells
    Mei Hua Li
    National Research Laboratory, College of Pharmacy, Seoul National University, Shinlim Dong, Kwanak Ku, Seoul 151 742, South Korea
    Free Radic Biol Med 41:1079-91. 2006
    ..there was a time-related increase in nuclear localization and subsequent binding of NF-E2-related factor 2 (Nrf2) to the antioxidant-responsive element (ARE)...
  4. doi Nrf2-dependent upregulation of antioxidative enzymes: a novel pathway for proteasome inhibitor-mediated cardioprotection
    Henryk Dreger
    Medizinische Klinik für Kardiologie und Angiologie, Campus Mitte, Charite Universitatsmedizin Berlin, Chariteplatz 1, D 10117 Berlin, Germany
    Cardiovasc Res 83:354-61. 2009
    ..Here, we have addressed the question whether the induction of antioxidative enzymes contributes to cardioprotection by non-toxic proteasome inhibition...
  5. doi Curcumin upregulates transcription factor Nrf2, HO-1 expression and protects rat brains against focal ischemia
    Chenhui Yang
    Department of Neurology, Second Hospital of Hebei Medical University, Shijiazhuang 050000, China
    Brain Res 1282:133-41. 2009
    ..The transcription factor nuclear factor erythroid 2-related factor 2 (Nrf2) coordinates expression of genes required for free radical scavenging, detoxification of xenobiotics, and ..
  6. doi Cyclo(His-Pro) up-regulates heme oxygenase 1 via activation of Nrf2-ARE signalling
    Alba Minelli
    Dipartimento Medicina Sperimentale Scienze Biochimiche, Sezione Biochimica Cellulare, Universita di Perugia, Perugia, Italia
    J Neurochem 111:956-66. 2009
    ..by the cleavage of the thyrotropin releasing hormone, has a cytoprotective effect through a mechanism involving Nrf2 activation that decreases production of reactive oxygen species and increases glutathione synthesis...
  7. doi Contribution of impaired Nrf2-Keap1 pathway to oxidative stress and inflammation in chronic renal failure
    Hyun Ju Kim
    Division of Nephrology and Hypertension, University of California, Irvine, California, USA
    Am J Physiol Renal Physiol 298:F662-71. 2010
    ..Nuclear factor erythroid-2-related factor-2 (Nrf2) confers protection against tissue injury by orchestrating antioxidant and detoxification responses to oxidative ..
  8. doi After cellular internalization, quercetin causes Nrf2 nuclear translocation, increases glutathione levels, and prevents neuronal death against an oxidative insult
    Florencia Arredondo
    Departamento de Neuroquimica, Instituto de Investigaciones Biologicas Clemente Estable, 11600 Montevideo, Uruguay
    Free Radic Biol Med 49:738-47. 2010
    ..We further explored the activation of the protective NF-E2-related factor 2 (Nrf2)-dependent signaling pathway by quercetin using immunocytochemistry techniques...
  9. doi Resveratrol protects diabetic kidney by attenuating hyperglycemia-mediated oxidative stress and renal inflammatory cytokines via Nrf2-Keap1 signaling
    P Palsamy
    Department of Biochemistry, University of Madras, Guindy Campus, Chennai, 600 025 Tamilnadu, India
    Biochim Biophys Acta 1812:719-31. 2011
    ..mRNA and protein analyses substantiated that resveratrol treatment notably normalizes the renal expression of Nrf2/Keap1and its downstream regulatory proteins in the diabetic group of rats...
  10. pmc Induction of NAD(P)H-quinone oxidoreductase 1 by antioxidants in female ACI rats is associated with decrease in oxidative DNA damage and inhibition of estrogen-induced breast cancer
    Bhupendra Singh
    Division of Pharmacology and Toxicology, School of Pharmacy, University of Missouri Kansas City, Kansas City, MO 64108, USA
    Carcinogenesis 33:156-63. 2012
    ..Nuclear factor erythroid 2-related factor 2 (NRF2) and NAD(P)H-quinone oxidoreductase 1 (NQO1) were suppressed in E2-exposed mammary tissue and in mammary tumors ..
  11. doi Redox-sensitive transcription factor Nrf2 regulates vascular smooth muscle cell migration and neointimal hyperplasia
    Takashi Ashino
    Division of Toxicology, Department of Pharmacology, Toxicology and Therapeutics, Showa University School of Pharmacy, 1 5 8 Hatanodai, Shinagawa ku, Tokyo 142 8555, Japan
    Arterioscler Thromb Vasc Biol 33:760-8. 2013
    ..Activation of the redox-sensitive transcription factor, nuclear factor erythroid 2-related factor 2 (Nrf2), is pivotal in cellular defense against oxidative stress by transcriptional upregulation of antioxidant proteins...
  12. pmc Role of impaired Nrf2 activation in the pathogenesis of oxidative stress and inflammation in chronic tubulo-interstitial nephropathy
    Mohammad A Aminzadeh
    Division of Nephrology and Hypertension, University of California, Irvine, CA, USA
    Nephrol Dial Transplant 28:2038-45. 2013
    ..by 5/6 nephrectomy are associated with an impaired activation of nuclear factor-erythroid-2-related factor 2 (Nrf2) which is the master regulator of genes encoding many antioxidant and detoxifying enzymes...
  13. doi Attenuation of UVB-induced sunburn reaction and oxidative DNA damage with no alterations in UVB-induced skin carcinogenesis in Nrf2 gene-deficient mice
    Yasuhiro Kawachi
    Department of Dermatology, Institute of Clinical Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan
    J Invest Dermatol 128:1773-9. 2008
    ..The transcription factor Nrf2 (NF-E2-related factor 2) and its negative regulator protein, Keap1 (Kelch-like-ECH-associated protein 1), are ..
  14. pmc Intrahippocampal injection of a lentiviral vector expressing Nrf2 improves spatial learning in a mouse model of Alzheimer's disease
    Katja Kanninen
    Departments of Neurobiology and Biotechnology and Molecular Medicine, A I Virtanen Institute for Molecular Sciences, University of Kuopio, FI 70211 Kuopio, Finland
    Proc Natl Acad Sci U S A 106:16505-10. 2009
    ..against oxidative stress is induced by binding of the transcription factor nuclear factor E2-related factor 2 (Nrf2) to the antioxidant response element (ARE) enhancer sequence...
  15. doi Nrf2/HO-1 pathway activation by manganese is associated with reactive oxygen species and ubiquitin-proteasome pathway, not MAPKs signaling
    Huangyuan Li
    Department of Occupational and Environmental Health, Fujian Medical University, Fuzhou, 350004, China
    J Appl Toxicol 31:690-7. 2011
    ..Accumulating data implicate NF-E2-related factor 2 (Nrf2) as a key regulator in the adaptive survival response to oxidative stress...
  16. doi Nrf2 expression by neurons, astroglia, and microglia in the cerebral cortical penumbra of ischemic rats
    Jon Dang
    Institute of Neuroanatomy, Medical Faculty, RWTH Aachen University, Aachen, Germany
    J Mol Neurosci 46:578-84. 2012
    ..Nuclear factor erythroid 2-related factor 2 (Nrf2) represents one of the major regulators implicated in the endogenous defense system against oxidative stress...
  17. doi DL-3-n-butylphthalide extends survival by attenuating glial activation in a mouse model of amyotrophic lateral sclerosis
    Xinhong Feng
    Department of Neurology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No 1, Shuaifuyuan, Dongcheng District, Beijing 100730, China
    Neuropharmacology 62:1004-10. 2012
    ..p65 and tumor necrosis factor-α (TNF-α) protein levels and a slight upregulation of NF-E2-related factor 2 (Nrf2) and heme oxygenase-1 (HO-1) were found in the spinal cord of Tg (SOD1-G93A) mice treated by dl-NBP...
  18. doi Melatonin inhibits type 1 interferon signaling of toll-like receptor 4 via heme oxygenase-1 induction in hepatic ischemia/reperfusion
    Jung Woo Kang
    School of Pharmacy, Sungkyunkwan University, Suwon, Korea
    J Pineal Res 53:67-76. 2012
    ..Melatonin enhanced the level of NF-E2-related factor-2 (Nrf2) nuclear translocation, and ZnPP reversed this increase...
  19. doi Melatonin activates the Nrf2-ARE pathway when it protects against early brain injury in a subarachnoid hemorrhage model
    Zhong Wang
    Department of Neurosurgery, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu Province, China
    J Pineal Res 53:129-37. 2012
    ..the relation between melatonin and nuclear factor erythroid 2-related factor 2 and antioxidant responsive element (Nrf2-ARE) pathway has not been studied in SAH models...
  20. ncbi Anti-fibrotic effects of L-2-oxothiazolidine-4-carboxylic acid via modulation of nuclear factor erythroid 2-related factor 2 in rats
    In Hee Kim
    Department of Internal Medicine, Chonbuk National University Medical School and Hospital, Jeonju 561 712, Korea
    BMB Rep 45:348-53. 2012
    ..anti-fibrotic and anti-oxidative effects of OTC via modulation of nuclear factor erythroid 2-related factor 2 (Nrf2) in an in vivo thioacetamide (TAA)-induced hepatic fibrosis model...
  21. doi The renoprotective effect of L-carnitine in hypertensive rats is mediated by modulation of oxidative stress-related gene expression
    Sonia Zambrano
    Departamento de Fisiologia, Facultad de Farmacia, Universidad de Sevilla, C Profesor García González 2, 41012 Sevilla, Spain
    Eur J Nutr 52:1649-59. 2013
    ..In addition, components of the renin-angiotensin system (RAS) and redox-sensitive transcription factors (NF-κB, Nrf2, and PPARα) have also been evaluated.
  22. ncbi Association between polymorphism of the NQO1, NOS3 and NFE2L2 genes and AMD
    Ewelina Synowiec
    Department of Ophthalmology, Medical University of Warsaw and Samodzielny Publiczny Kliniczny Szpital Okulistyczny, Sierakowskiego 13, 03 709 Warsaw, Poland
    Front Biosci (Landmark Ed) 18:80-90. 2013
    ..and removal of iron-mediated oxidation: NQO1 (609C> T, rs1800566), NOS3 (894G>T, rs1799983) and NFE2L2 (28312647A>G, rs6726395)...
  23. pmc Alcohol causes alveolar epithelial oxidative stress by inhibiting the nuclear factor (erythroid-derived 2)-like 2-antioxidant response element signaling pathway
    J Spencer Jensen
    Atlanta Veterans Affairs Medical Center, Decatur, GA, USA
    Am J Respir Cell Mol Biol 48:511-7. 2013
    ..Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) is a redox-sensitive master transcription factor that regulates activation of the antioxidant response element (..
  24. doi Resveratrol protects spinal cord dorsal column from hypoxic injury by activating Nrf-2
    V Kesherwani
    Division of Neurosurgery, Department of Surgery, University of Nebraska Medical Center, Omaha, NE 68198 7690, USA
    Neuroscience 241:80-8. 2013
    ..The neuroprotective effect is likely to be exerted by increased activation of transcription factor Nrf-2 by resveratrol along with its direct antioxidant effect to ameliorate the oxidative damage and preserve mitochondrial function...
  25. pmc Diet-relevant phytochemical intake affects the cardiac AhR and nrf2 transcriptome and reduces heart failure in hypertensive rats
    E Mitchell Seymour
    University of Michigan Cardiovascular Center, Ann Arbor, MI 48109, USA
    J Nutr Biochem 24:1580-6. 2013
    ..Phytochemicals alter in vitro aryl hydrocarbon receptor (AhR) and NF-E2 related factor (nrf2) transcription factor activity and related genes pertinent to antioxidant defense...
  26. pmc Naphthazarin protects against glutamate-induced neuronal death via activation of the Nrf2/ARE pathway
    Tae Gen Son
    Laboratory of Neurosciences, National Institute on Aging, Intramural Research Program, 251 Bayview Blvd, Baltimore, MD 21224, USA
    Biochem Biophys Res Commun 433:602-6. 2013
    Nuclear factor E2-related factor 2 (Nrf2)/antioxidant response element (ARE) pathway is an important cellular stress response pathway involved in neuroprotection...
  27. doi Nrf2-regulated phase-II detoxification enzymes and phase-III transporters are induced by thyroid hormone in rat liver
    Pamela Cornejo
    Faculty of Medicine, Diego Portales University, Santiago, Chile
    Biofactors 39:514-21. 2013
    ..of reactive oxygen species (ROS) and redox-sensitive nuclear transcription factor erythroid 2-related factor 2 (Nrf2) activation...
  28. pmc Temporal and spatial distribution of Nrf2 in rat brain following stroke: quantification of nuclear to cytoplasmic Nrf2 content using a novel immunohistochemical technique
    Salil Srivastava
    Cardiovascular Division, BHF Centre of Research Excellence, School of Medicine, King s College London, Franklin Wilkins Building, 150 Stamford Street, London SE1 9NH, UK
    J Physiol 591:3525-38. 2013
    Activation of the redox-sensitive transcription factor NF-E2 related factor 2 (Nrf2) affords protection against cerebral ischaemia-reperfusion injury via the upregulation of antioxidant defence genes...
  29. pmc Lipoxin A4-induced heme oxygenase-1 protects cardiomyocytes against hypoxia/reoxygenation injury via p38 MAPK activation and Nrf2/ARE complex
    Xiao Qing Chen
    Department of Pediatrics, First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, People s Republic of China
    PLoS ONE 8:e67120. 2013
    ....
  30. pmc tert-Butylhydroquinone (tBHQ) protects hepatocytes against lipotoxicity via inducing autophagy independently of Nrf2 activation
    Songtao Li
    Department of Kinesiology and Nutrition, University of Illinois at Chicago, Chicago, IL 60612, USA Department of Nutrition and Food Hygiene, Public Health College, Harbin Medical University, Harbin 150081, PR China
    Biochim Biophys Acta 1841:22-33. 2014
    ..Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) is a master transcriptional regulator of cellular antioxidant defense enzymes...
  31. pmc Neuronal activity regulates astrocytic Nrf2 signaling
    Agata Habas
    Department of Pathology, University of California, San Francisco, CA 94143
    Proc Natl Acad Sci U S A 110:18291-6. 2013
    Nuclear factor erythroid 2-related factor 2 (Nrf2), the transcriptional master regulator of the stress-induced antioxidant response, plays a key role in neuronal resistance to oxidative stress and glutamate-induced excitotoxicity...
  32. doi Nrf2 activation in the liver of rats subjected to a preconditioning sub-chronic iron protocol
    Paula Morales
    Molecular and Clinical Pharmacology Program, Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, Santiago, Chile
    Food Funct 5:243-50. 2014
    ..cytoprotective mechanisms that may involve redox-sensitive nuclear factor erythroid 2-related factor 2 (Nrf2)...
  33. doi Delayed remote ischemic preconditioning produces an additive cardioprotection to sevoflurane postconditioning through an enhanced heme oxygenase 1 level partly via nuclear factor erythroid 2-related factor 2 nuclear translocation
    Chenghui Zhou
    Department of Anesthesiology, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
    J Cardiovasc Pharmacol Ther 19:558-66. 2014
    ..Such trend was also observed in the nuclear factor erythroid 2-related factor 2 (Nrf2) nuclear translocation, an upstream regulation of HO-1...
  34. pmc Essential role of PH domain and leucine-rich repeat protein phosphatase 2 in Nrf2 suppression via modulation of Akt/GSK3β/Fyn kinase axis during oxidative hepatocellular toxicity
    F Rizvi
    1 Academy of Scientific and Innovative Research, New Delhi, India 2 Herbal Research Section, Food Drug and Chemical Toxicology Division, Council of Scientific and Industrial Research Indian Institute of Toxicology Research CSIR IITR, Lucknow, India
    Cell Death Dis 5:e1153. 2014
    Instances of sustained oxidative activity have been shown to involve dysregulation of Nrf2-mediated transcriptional induction; however, mechanisms warranting Nrf2-repression remain unclear...
  35. doi Naringenin attenuates CCl4 -induced hepatic inflammation by the activation of an Nrf2-mediated pathway in rats
    Mohammad Ali Esmaeili
    Department of Biology, Medicinal Plants and Drug Research Institute, Shahid Beheshti University, Tehran, Iran
    Clin Exp Pharmacol Physiol 41:416-22. 2014
    ..Naringenin treatment significantly increased NF-E2-related factor 2 (Nrf2) and heme oxygenase (HO-1) expression in injured livers...
  36. doi Derivative of bardoxolone methyl, dh404, in an inverse dose-dependent manner lessens diabetes-associated atherosclerosis and improves diabetic kidney disease
    Sih Min Tan
    Oxidative Stress Laboratory, Diabetic Complications Division, Baker IDI Heart and Diabetes Institute, Melbourne, Australia
    Diabetes 63:3091-103. 2014
    ..In this study, we have used a novel analog of the NFE2-related factor 2 (Nrf2) agonist bardoxolone methyl, dh404, to investigate its effects on diabetic macrovascular and renal injury in ..
  37. doi Regulation of hemeoxygenase-1 gene expression by Nrf2 and c-Jun in tertiary butylhydroquinone-stimulated rat primary astrocytes
    Jin Sun Park
    Department of Molecular Medicine and Global Top5 Research Program, Tissue Injury Defense Research Center, Ewha Womans University Medical School, Seoul 158 710, Republic of Korea
    Biochem Biophys Res Commun 447:672-7. 2014
    ..In addition, tBHQ increased the nuclear translocation and DNA binding of Nrf2 and c-Jun to ARE...
  38. pmc Nrf2-inducing anti-oxidation stress response in the rat liver--new beneficial effect of lansoprazole
    Yasunobu Yamashita
    2nd Department of Internal Medicine, Wakayama Medical University Graduate School of Medicine, Wakayama, Japan
    PLoS ONE 9:e97419. 2014
    ..rats produced a dose-dependent increase in hepatic mRNA levels of nuclear factor, erythroid-derived 2, -like 2 (Nrf2), a redox-sensitive transcription factor, at 3 h and Nrf2 immunoreactivity (IR) in whole hepatic lysates at 6 h...
  39. doi CO Induces Nrf2-Dependent Heme Oxygenase-1 Transcription by Cooperating with Sp1 and c-Jun in Rat Brain Astrocytes
    Pei Ling Chi
    Department of Physiology and Pharmacology and Health Ageing Research Center, College of Medicine, Chang Gung University, 259 Wen Hwa 1st Road, Kwei Shan, 33302, Tao Yuan, Taiwan
    Mol Neurobiol 52:277-92. 2015
    ..interfering RNA (siRNA) of c-Jun, specificity protein 1 (Sp1), or nuclear factor-erythroid 2-related factor 2 (Nrf2). Immunoprecipitation assay showed that CORM-2 increased the association of nuclear Nrf2 with Sp1 and c-Jun...
  40. doi Antiarrhythmic effect of lithium in rats after myocardial infarction by activation of Nrf2/HO-1 signaling
    Tsung Ming Lee
    Cardiology Section, Department of Medicine, China Medical University An Nan Hospital, Tainan 709, Taiwan Department of Medicine, China Medical University, Taichung, Taiwan Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan
    Free Radic Biol Med 77:71-81. 2014
    ..GSK-3) signaling has been shown to play a role in the regulation of nuclear factor erythroid-2-related factor 2 (Nrf2), a master regulator of antioxidant genes, including heme oxygenase-1 (HO-1)...
  41. doi Role of Nrf2 signal pathway in rats with deep hypothermia ischemia/reperfusion injury undergoing remote postconditioning
    Z Y Wu
    Department of Cardiovascular Surgery, Renmin Hospital of Wuhan University, Wuhan, China
    Genet Mol Res 14:492-9. 2015
    ..of rats with deep hypothermia ischemia/reperfusion (I/R) injury and the role of nuclear factor E2-related factor 2 (Nrf2) signaling in this process...
  42. doi The protective effects of endogenous hydrogen sulfide modulator, S-propargyl-cysteine, on high glucose-induced apoptosis in cardiomyocytes: A novel mechanism mediated by the activation of Nrf2
    Hebei Yang
    Department of Pharmacology, School of Pharmacy, Fudan University, Shanghai, China
    Eur J Pharmacol 761:135-43. 2015
    ..SPRC increased stability and nuclear translocation of Nuclear factor erythroid 2-related factor 2 (Nrf2), up-regulated expression of antioxidant enzyme superoxide dismutase (SOD) and interfered with the interaction ..
  43. pmc N-acetylcysteine protects against liver injure induced by carbon tetrachloride via activation of the Nrf2/HO-1 pathway
    Zhaobin Cai
    Xixi Hospital of Hangzhou Affiliated to Zhejiang University of Traditional Chinese Medicine Hangzhou, Zhejiang, People s Republic of China
    Int J Clin Exp Pathol 8:8655-62. 2015
    ..Treatment with NAC had been shown to an increase in nuclear factor erythroid 2-related factor 2 (Nrf2) and heme oxygenase-1 (HO-1) mRNA levels...
  44. doi Nrf2 transcriptional derepression from Keap1 by dietary polyphenols
    Henry K Bayele
    Department of Structural and Molecular Biology, Division of Biosciences, University College London, Gower Street, London WC1E 6BT, United Kingdom Electronic address
    Biochem Biophys Res Commun 469:521-8. 2016
    ..These genes are mainly regulated by Nrf2, making this transcription factor a target for small molecule discovery to treat such diseases...
  45. doi Hyperbaric oxygen preconditioning ameliorates hypoxia-ischemia brain damage by activating Nrf2 expression in vivo and in vitro
    Xiao Zhai
    a Graduate Management Unit of Changhai Hospital Affiliated to the Second Military Medical University, Shanghai, PR China
    Free Radic Res 50:454-66. 2016
    ..hyperbaric oxygen preconditioning (HBO-PC) could ameliorate hypoxia-ischemia brain damage (HIBD) by an increase of Nrf2 expression...
  46. pmc BQ123 Stimulates Skeletal Muscle Antioxidant Defense via Nrf2 Activation in LPS-Treated Rats
    Agata Kowalczyk
    Department of Cardiovascular Physiology, Chair of Experimental and Clinical Physiology, Medical University of Lodz, 6 8 Mazowiecka Street, 92 215 Lodz, Poland
    Oxid Med Cell Longev 2016:2356853. 2016
    ..to evaluate whether BQ123, an endothelin-A receptor antagonist, influences the level of TNF-α, IL-6, SOD-1, HO-1, Nrf2 mRNA, and NF-κB subunit RelA/p65 mRNA in the femoral muscle obtained from endotoxemic rats...
  47. pmc Hawthorn Fruit Extract Elevates Expression of Nrf2/HO-1 and Improves Lipid Profiles in Ovariectomized Rats
    Jeong Hyun Yoo
    Division of Food and Nutritional Science and Life Systems, College of Science, Sookmyung Women s University, Seoul 04310, Korea
    Nutrients 8:. 2016
    ..05). The mRNA expression of nuclear factor erythroid 2-related factor (Nrf2), heme oxygenase-1 (HO-1), and glutathione peroxidase (GPx) were significantly decreased in the OVX group, whereas ..
  48. pmc Salvianolic Acid B Prevents Iodinated Contrast Media-Induced Acute Renal Injury in Rats via the PI3K/Akt/Nrf2 Pathway
    Liu Tongqiang
    Division of Nephrology, Zhongshan Hospital, Fudan University, Shanghai 200032, China Division of Nephrology, The Affiliated Changzhou No 2 Hospital of Nanjing Medical College, Changzhou, Jiangsu 213003, China
    Oxid Med Cell Longev 2016:7079487. 2016
    ..histological changes of renal tubular injuries, reduced the number of apoptosis-positive tubular cells, activated Nrf2, and lowered the levels of renal oxidative stress induced by iodinated contrast media...
  49. doi Lipopolysaccharide-induced preconditioning protects against traumatic spinal cord injury by upregulating Nrf2 expression in rats
    Weichao Li
    Faculty of Medical Science, Kunming University of Science and Technology, Kunming, China Department of Orthopedic Surgery, First People s Hospital of Yunnan Province, Affiliated Hospital of Kunming University of Science and Technology, Kunming, China Electronic address
    Life Sci 162:14-20. 2016
    Lipopolysaccharide (LPS)-induced preconditioning protects neurons against traumatic spinal cord injury (TSCI) in rats. This study sought to test whether Nrf2, a transcription factor, mediated LPS-induced preconditioning.
  50. ncbi Activation of the Nrf2 Signaling Pathway Involving KLF9 Plays a Critical Role in Allicin Resisting Against Arsenic Trioxide-Induced Hepatotoxicity in Rats
    Daqian Yang
    College of Veterinary Medicine, Northeast Agricultural University, 59 Mucai Street, Harbin, 150030, China
    Biol Trace Elem Res . 2016
    ..of proteins reduced by As2O3 including nuclear factor erythroid 2-related factor 2 (Nrf2), heme oxygenase 1, nicotinamide adenine dinucleotide phosphate:quinone oxidoreductase 1, and Krüppel-like factor ..
  51. doi Intranasal insulin exerts beneficial effects by improving cerebral blood flow, Nrf-2 expression and BDNF in STZ (ICV) induced memory-impaired rats
    N Rajasekar
    Divisions of Pharmacology and Toxicology, CSIR Central Drug Research Institute, Lucknow, 226031, India Academy of Scientific and Innovative Research AcSIR, Chennai, India
    Life Sci . 2016
    ..But, their neuroprotective mechanisms are largely unexplored. Therefore, we investigated the protective effect of intranasal insulin in intracerebroventricular (ICV) streptozotocin (STZ) induced memory impairment in rats...
  52. pmc Transcription factor Nrf2 regulates inflammation by mediating the effect of 15-deoxy-Delta(12,14)-prostaglandin j(2)
    Ken Itoh
    ERATO Environmental Response Project, University of Tsukuba, Tsukuba 305 8577, Japan
    Mol Cell Biol 24:36-45. 2004
    Activated macrophages express high levels of Nrf2, a transcription factor that positively regulates the gene expression of antioxidant and detoxication enzymes...
  53. pmc Genetic or pharmacologic amplification of nrf2 signaling inhibits acute inflammatory liver injury in mice
    William O Osburn
    Department of Environmental Health Sciences, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland, USA
    Toxicol Sci 104:218-27. 2008
    ..The transcription factor NF-E2-related factor 2 (Nrf2) regulates the expression of a battery of antioxidative enzymes and Nrf2 signaling can be activated by small-..
  54. doi Epigallocatechin-3-gallate augments antioxidant activities and inhibits inflammation during bleomycin-induced experimental pulmonary fibrosis through Nrf2-Keap1 signaling
    Narayanan Sriram
    Department of Biochemistry, University of Madras, Guindy Campus, Chennai 600 025, Tamilnadu, India
    Pulm Pharmacol Ther 22:221-36. 2009
    ..Confocal microscopy, immunoblot and RT-PCR studies confirm that EGCG is a potent inducer of NF-E2-related factor 2 (Nrf2)...
  55. doi Nrf2-encoding NFE2L2 haplotypes influence disease progression but not risk in Alzheimer's disease and age-related cataract
    Malin von Otter
    Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, Bla Straket 15, the Sahlgrenska Academy at University of Gothenburg, S 413 45 Gothenburg, Sweden
    Mech Ageing Dev 131:105-10. 2010
    ..We hypothesize that common variants of NFE2L2 and KEAP1, the genes encoding the main regulators of the Nrf2 system, an important defence system against ..
  56. ncbi [Roles of NRF2 regulating gamma-glutamylcysteine synthetase in lung of rats with chronic obstructive pulmonary disease]
    Lin Chen
    Department of Respiratory Medicine, Geriatric Hospital of Hunan Province, Changsha 410001, China
    Zhongguo Ying Yong Sheng Li Xue Za Zhi 24:339-42. 2008
    ..synthetase (gamma-GCS) and NF-E2-related factor2 (NRR2) in lung of rat with chronic obstructive pulmonary disease (COPD)in order to elucidate the possible important role of gamma-GCS and NRF2 in pathogenesis of COPD.
  57. pmc Thiol redox disturbances in children with severe asthma are associated with posttranslational modification of the transcription factor nuclear factor (erythroid-derived 2)-like 2
    Anne M Fitzpatrick
    Department of Pediatrics, Emory University, Atlanta, GA, USA
    J Allergy Clin Immunol 127:1604-11. 2011
    ..Airway thiol redox disturbances, including depletion of the antioxidant, glutathione, are differentiating features of severe asthma in children...
  58. pmc Activation of the nuclear factor E2-related factor 2/antioxidant response element pathway is neuroprotective after spinal cord injury
    Xiaoliang Wang
    Department of Neurosurgery, Jinling Hospital, School of Medicine, Nanjing University, Nanjing, Jiangsu Province, People s Republic of China
    J Neurotrauma 29:936-45. 2012
    ..lead to cell death and are tightly regulated by nuclear factor E2-related factor 2/antioxidant response element (Nrf2/ARE) signaling. Here, we investigated whether activation of Nrf2/ARE is neuroprotective following SCI...
  59. doi A defect in Nrf2 signaling constitutes a mechanism for cellular stress hypersensitivity in a genetic rat model of type 2 diabetes
    Milad S Bitar
    Department of Pharmacology, Faculty of Medicine, Health Sciences Center, University of Kuwait, Safat, Kuwait
    Am J Physiol Endocrinol Metab 301:E1119-29. 2011
    b>Nrf2 regulates the expression and coordinated induction of a battery of antioxidant phase 2 genes that protect cells against the cumulative damaging effects of oxidative stress (OS), a major contributor in the development of chronic ..
  60. doi Danshen-Gegen decoction protects against hypoxia/reoxygenation-induced apoptosis by inhibiting mitochondrial permeability transition via the redox-sensitive ERK/Nrf2 and PKCε/mKATP pathways in H9c2 cardiomyocytes
    Po Yee Chiu
    Division of Life Science, The Hong Kong University of Science and Technology, Clear Water Bay, China
    Phytomedicine 19:99-110. 2012
    ..The DG-induced ERK1/2 activation was followed by the translocation of Nrf2 from the cytosol to the mitochondria accompanied by an increase in the expression of glutathione-related ..
  61. doi Low-molecular-weight compounds having neurotrophic activity in cultured PC12 cells and neurons
    Hiroki Maruoka
    Laboratory of Neurobiology, Department of Life Science and Biotechnology, Materials and Bioengineering and Strategic Research Base, Kansai University, Suita, Osaka, Japan
    J Biochem 150:473-5. 2011
    ..Carnosic acid (CA) promotes neurite outgrowth through the activation of Nrf2 in PC12 cells. CA also protects neurons via the keap/Nrf2 transcriptional pathway from oxidative stress...
  62. doi Induction of glutathione synthesis and heme oxygenase 1 by the flavonoids butein and phloretin is mediated through the ERK/Nrf2 pathway and protects against oxidative stress
    Ya Chen Yang
    Department of Health and Nutrition Biotechnology, Asia University, Taichung, Taiwan
    Free Radic Biol Med 51:2073-81. 2011
    ..Butein treatment activated the ERK1/2 signaling pathway and increased Nrf2 nuclear translocation, Nrf2 nuclear protein-DNA binding activity, and ARE-luciferase reporter activity...
  63. doi Carnosic acid induces the NAD(P)H: quinone oxidoreductase 1 expression in rat clone 9 cells through the p38/nuclear factor erythroid-2 related factor 2 pathway
    Chia Wen Tsai
    Department of Nutrition, China Medical University, Taichung 404, Taiwan
    J Nutr 141:2119-25. 2011
    ..Furthermore, CA dose dependently induced transcription of nuclear factor erythroid-2 related factor 2 (Nrf2) and antioxidant response element (ARE)-luciferase reporter activity...
  64. pmc Identification of age-specific Nrf2 binding to a novel antioxidant response element locus in the Gclc promoter: a compensatory means for the loss of glutathione synthetic capacity in the aging rat liver?
    Swapna V Shenvi
    Molecular and Cellular Biology Program, Oregon State University, Corvallis, OR 97331, USA
    Aging Cell 11:297-304. 2012
    NFE2-related factor 2 (Nrf2) transcriptionally governs the cellular response to harmful electrophiles, xenobiotics, and reactive oxygen species. Its nuclear levels decline with age (Suh et al...
  65. doi Nrf2 inhibits hepatic iron accumulation and counteracts oxidative stress-induced liver injury in nutritional steatohepatitis
    Kosuke Okada
    Field of Basic Sports Medicine, Sports Medicine, Faculty of Medicine, Graduate School of Comprehensive Human Sciences, The University of Tsukuba, Tsukuba, Ibaraki, 305 8574, Japan
    J Gastroenterol 47:924-35. 2012
    The transcription factor nuclear factor-E2-related factor-2 (Nrf2) is a key regulator for induction of hepatic antioxidative stress systems. We aimed to investigate whether activation of Nrf2 protects against steatohepatitis.
  66. doi Extremely low-frequency electromagnetic fields activate the antioxidant pathway Nrf2 in a Huntington's disease-like rat model
    Inmaculada Tasset
    Departamento de Bioquimica y Biologia Molecular, Facultad de Medicina, Instituto Maimónides de Investigación Biomédica de Córdoba Universidad de Córdoba, Cordoba, Spain
    Brain Stimul 6:84-6. 2013
    ..This study shows that TMS can modulate the Nrf2 transcriptor factor in a Huntington's disease-like rat model induced by 3-nitropropionic acid (3-NP)...
  67. doi Aldehyde oxidase 1 gene is regulated by Nrf2 pathway
    Kenichiro Maeda
    Division of Radiological Technology, Department of Health Sciences, School of Medicine, Hokkaido University, Kita 12, Nishi 5, Sapporo 060 0812, Japan
    Gene 505:374-8. 2012
    ..Here, we found that the AOX1 gene is regulated by the Nrf2 pathway...
  68. ncbi [Effect of ulinastatin on oxidative stress and nuclear factor E2-related factor 2 expression in the lung tissues of acute hydrogen sulfide intoxicated rats]
    Yun Ge
    Emergency Department, First Affiliated Hospital of Wen Zhou Medical College, Wenzhou, Zhejiang Province 325000, China
    Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 30:27-32. 2012
    To investigate the dynamic changes of oxidative stress and nuclear factor-E2 related factor 2 (Nrf2) expression in the lung tissues of acute hydrogen sulfide (H2S) intoxicated rats and intervention effects of ulinastatin (UTI).
  69. ncbi [The effect of transcription factor KLF2 in expression of gamma-GCS depend on regulation by Nrf2 in lung of rats with chronic obstructive pulmonary disease]
    Xiao Yan Liu
    Department of Respiratory Disease, Hunan Institute of Gerontology, Hunan Geriatric Hospital, Changsha 410016, China
    Zhongguo Ying Yong Sheng Li Xue Za Zhi 28:173-8. 2012
    ..rats with chronic obstructive pulmonary disease (COPD) and the relationship between KLF2 and NF-E2-related factor 2 (Nrf2), and make further explore the effects of KLF2 on the expression of gamma-glutamylcysteine synthetase (gamma-GCS).
  70. doi The enhancement of phase 2 enzyme activities by sodium butyrate in normal intestinal epithelial cells is associated with Nrf2 and p53
    Keisuke Yaku
    Department of Food and Human Health Sciences, Graduate School of Human Life Science, Osaka City University, Sumiyoshi ku, Osaka, Japan
    Mol Cell Biochem 370:7-14. 2012
    ..sodium butyrate, but not other short-chain fatty acids was related to the increase of NF-E2-related factor 2 (Nrf2) nuclear translocation and the decrease in the levels of nuclear fraction p53...
  71. doi Tomato powder impedes the development of azoxymethane-induced colorectal cancer in rats through suppression of COX-2 expression via NF-κB and regulating Nrf2/HO-1 pathway
    Mehmet Tuzcu
    Department of Biology, Faculty of Science, Firat University, Elazig, Turkey
    Mol Nutr Food Res 56:1477-81. 2012
    ..of cyclooxygenase-2 (COX-2) expression via NF-κB pathway and promotion of apoptosis, as well as regulating Nrf2/HO-1 signaling pathway in colorectal tissue of AOM-treated rats...
  72. pmc Age-related cataracts: homocysteine coupled endoplasmic reticulum stress and suppression of Nrf2-dependent antioxidant protection
    Rajan Elanchezhian
    Department of Ophthalmology and Visual Sciences, University of Nebraska Medical Center, Omaha, NE, USA
    Chem Biol Interact 200:1-10. 2012
    ..Hcy) induce endoplasmic reticulum (ER) stress with suppression of the nuclear factor-erythroid-2-related factor 2 (Nrf2)-dependent antioxidant protection in lens epithelial cells (LECs)...
  73. doi [Effect of reduced glutathione on proliferation of rat hepatic stellate cells and the Nrf2/HO-1 signaling pathway]
    Li Zhang
    Department of Infectious Disease, The First Hospital of Shanxi Medical University, Taiyuan, China
    Zhonghua Gan Zang Bing Za Zhi 20:507-11. 2012
    To explore the effects of reduced glutathione (GSH) on the proliferation of hepatic stellate cells and the nuclear factor erythroid 2-related factor 2 (Nrf2)/heme oxygenase-1 (HO-1) signaling pathway.
  74. pmc Dimethylfumarate attenuates renal fibrosis via NF-E2-related factor 2-mediated inhibition of transforming growth factor-β/Smad signaling
    Chang Joo Oh
    Department of Internal Medicine, Research Institute of Aging and Metabolism, WCU Program, Kyungpook National University School of Medicine, Daegu, Republic of Korea
    PLoS ONE 7:e45870. 2012
    ..signaling pathway is a possible therapeutic approach for preventing this disease, and reports have suggested that Nrf2 protects against renal fibrosis by inhibiting TGF-β signaling...
  75. pmc Desipramine protects neuronal cell death and induces heme oxygenase-1 expression in Mes23.5 dopaminergic neurons
    Hsiao Yun Lin
    Department of Life Sciences, National Chung Hsing University, Taichung, Taiwan
    PLoS ONE 7:e50138. 2012
    ..It has also been used in a number of other psychiatric and medical conditions. The present study is the first to investigate the neuroprotective effect of desipramine...
  76. doi Nrf2 activators attenuate the progression of nonalcoholic steatohepatitis-related fibrosis in a dietary rat model
    Rieko Shimozono
    Toray Industries, Inc, Pharmaceutical Research Laboratories, Kanagawa, Japan
    Mol Pharmacol 84:62-70. 2013
    ..The transcription factor Nrf2 (nuclear factor-erythroid-2-related factor 2) plays a central role in stimulating expression of various antioxidant-..
  77. ncbi Phosphorylation of Nrf2 at Ser-40 by protein kinase C regulates antioxidant response element-mediated transcription
    H C Huang
    Schering Plough Research Institute, Kenilworth, New Jersey 07033, USA
    J Biol Chem 277:42769-74. 2002
    b>Nrf2, a basic leucine zipper transcription factor, is an essential activator of the coordinated transcription of genes encoding antioxidant enzymes and phase II detoxifying enzymes through the regulatory sequence termed antioxidant ..
  78. ncbi Phosphatidylinositol 3-kinase regulates nuclear translocation of NF-E2-related factor 2 through actin rearrangement in response to oxidative stress
    Keon Wook Kang
    College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Kwanak gu, Seoul, South Korea
    Mol Pharmacol 62:1001-10. 2002
    Expression of phase II detoxifying genes is regulated by NF-E2-related factor 2 (Nrf2)-mediated antioxidant response element (ARE) activation...
  79. ncbi Coordinate regulation of glutathione metabolism in astrocytes by Nrf2
    Xiaojian Sun
    Department of Psychiatry, Kinsmen Laboratory of Neurological Research and Brain Research Center, 4835 2255 Wesbrook Mall, University of British Columbia, Vancouver, BC, Canada V6T 1Z3
    Biochem Biophys Res Commun 326:371-7. 2005
    ..and after induction of antioxidant response element (ARE)-mediated gene expression by the transcription factor Nrf2. In the presence of a cerebral spinal fluid-like salt solution astrocytes could not synthesize detectable levels of ..
  80. ncbi Fibroblast growth factor-1 induces heme oxygenase-1 via nuclear factor erythroid 2-related factor 2 (Nrf2) in spinal cord astrocytes: consequences for motor neuron survival
    Marcelo R Vargas
    Departamento de Neurobiologia Celular y Molecular, Instituto de Investigaciones Biologicas Clemente Estable, Montevideo 11600, Uruguay
    J Biol Chem 280:25571-9. 2005
    ..FGF-1 also induced Nrf2 mRNA and protein levels and prompted its nuclear translocation...
  81. pmc Glucocorticoid receptor (GR)-associated SMRT binding to C/EBPbeta TAD and Nrf2 Neh4/5: role of SMRT recruited to GR in GSTA2 gene repression
    Sung Hwan Ki
    College of Pharmacy, Seoul National University, Sillim dong, Kwanak gu, Seoul 151 742, South Korea
    Mol Cell Biol 25:4150-65. 2005
    ..is regulated by activation of CCAAT/enhancer binding protein beta (C/EBPbeta) and NF-E2-related factor 2 (Nrf2)...
  82. pmc Nrf1 and Nrf2 regulate rat glutamate-cysteine ligase catalytic subunit transcription indirectly via NF-kappaB and AP-1
    Heping Yang
    Division of Gastroenterology and Liver Diseases, USC Research Center for Liver Diseases, Keck School of Medicine USC, Los Angeles, California 90033, USA
    Mol Cell Biol 25:5933-46. 2005
    Glutamate-cysteine ligase catalytic subunit (GCLC) is regulated transcriptionally by Nrf1 and Nrf2. tert-Butylhydroquinone (TBH) induces human GCLC via Nrf2-mediated trans activation of the antioxidant-responsive element (ARE)...
  83. ncbi Nrf2 is increased by CYP2E1 in rodent liver and HepG2 cells and protects against oxidative stress caused by CYP2E1
    Pengfei Gong
    Department of Pharmacology and Biological Chemistry, Mount Sinai School of Medicine, New York, NY 10029, USA
    Hepatology 43:144-53. 2006
    Induction of CYP2E1 by ethanol is one pathway through which ethanol generates oxidative stress. Nrf2 is a transcription factor that regulates important antioxidant and phase II detoxification genes...
  84. ncbi [Time course of gene expression of gamma-glutamylcysteine synthetase subunit and Nrf2 in brain tissues of rats exposed by deltamethrin]
    Huang Yuan Li
    Department of Health Toxicology, MOE Key Lab of Enviornment and health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
    Wei Sheng Yan Jiu 35:130-4. 2006
    ..gamma- glutamylcysteine synthetase light (GCSl) and heavy subunit (GCSh), as well as protein expression of both GCSh and NF-E2 related factor 2 (Nrf2) in cerebral cortex and hippocampus in rats exposed at single dose of deltamethrin (DM).
  85. ncbi Inchinkoto, a herbal medicine, and its ingredients dually exert Mrp2/MRP2-mediated choleresis and Nrf2-mediated antioxidative action in rat livers
    Kosuke Okada
    Dept of Gastroenterology, Graduate School of Comprehensive Human Sciences, Univ of Tsukuba, 1 1 1 Tennodai, Tsukuba shi, Ibaraki 305 8575, Japan
    Am J Physiol Gastrointest Liver Physiol 292:G1450-63. 2007
    ..The treatment also increased hepatic levels of heme oxygenase-1 and GSH by a nuclear factor-E2-related factor (Nrf2)-dependent mechanism...
  86. pmc Histone acetyltransferase MOZ acts as a co-activator of Nrf2-MafK and induces tumour marker gene expression during hepatocarcinogenesis
    Kumiko Ohta
    Laboratory of Environmental Biochemistry, Graduate School of Pharmaceutical Sciences, Osaka University, 1 6 Yamada oka, Suita, Osaka 565 0871, Japan
    Biochem J 402:559-66. 2007
    ..GSTP gene activation is regulated mainly by the GPE1 (GSTP enhancer 1) enhancer element, which is recognized by the Nrf2 (nuclear factor-erythroid 2 p45 subunit-related factor 2)-MafK heterodimer...
  87. ncbi Dopamine activates Nrf2-regulated neuroprotective pathways in astrocytes and meningeal cells
    Andy Y Shih
    Kinsmen Laboratory of Neurological Research, Department of Psychiatry, University of British Columbia, Vancouver, British Columbia, Canada
    J Neurochem 101:109-19. 2007
    The transcription factor Nrf2 controls inducible expression of multiple antioxidant/detoxification genes. We previously found that Nrf2-/- mice have increased sensitivity to in vivo mitochondrial stress and ischemia...
  88. pmc Nitro-linoleic acid inhibits vascular smooth muscle cell proliferation via the Keap1/Nrf2 signaling pathway
    Luis Villacorta
    Department of Internal Medicine, Cardiovascular Center, University of Michigan Medical Center, 1150 W Medical Center Drive, Ann Arbor, MI 48109, USA
    Am J Physiol Heart Circ Physiol 293:H770-6. 2007
    ..Furthermore, LNO(2) triggered nuclear factor-erythroid 2-related factor 2 (Nrf2) nuclear translocation and activation of the antioxidant-responsive element-driven transcriptional activity via ..
  89. ncbi Carbon monoxide produced by heme oxygenase-1 in response to nitrosative stress induces expression of glutamate-cysteine ligase in PC12 cells via activation of phosphatidylinositol 3-kinase and Nrf2 signaling
    Mei Hua Li
    National Research Laboratory of Molecular Carcinogenesis and Chemoprevention, College of Pharmacy, Seoul National University, Seoul 151 742, South Korea
    J Biol Chem 282:28577-86. 2007
    ..Furthermore, CO-RM treatment up-regulated GCLC expression through activation of Nrf2. The CO-RM-induced activation of Nrf2 was under the control of the phosphatidylinositol 3-kinase/Akt signaling ..
  90. ncbi Enhancing expression of Nrf2-driven genes protects the blood brain barrier after brain injury
    Jing Zhao
    The Vivian L Smith Center for Neurologic Research and Department of Neurobiology and Anatomy, The University of Texas Medical School, Houston, Texas 77225, USA
    J Neurosci 27:10240-8. 2007
    ..Activation of the transcription factor NF-E2-related factor-2 (Nrf2) by sulforaphane, a naturally occurring compound present in high levels in cruciferous vegetables, significantly ..
  91. ncbi Transcription factor Nrf2 protects the brain from damage produced by intracerebral hemorrhage
    Xiurong Zhao
    Department of Neurology, University of Texas at Health Science Center at Houston, Houston, TX 77030, USA
    Stroke 38:3280-6. 2007
    ..Recent studies have suggested that nuclear factor-erythroid 2-related factor 2 (Nrf2), a pleiotropic transcription factor, may play a key role in protecting cells from cytotoxic/oxidative damage...
  92. ncbi Development of glutathione S-transferase-P-negative foci accompanying nuclear factor-erythroid 2-related factor 2 expression during early stage of rat hepatocarcinogenesis
    Yang Fan
    Department of Biochemistry and Genome Biology, Hirosaki University Graduate School of Medicine, 5 Zaifu cho, Hirosaki 036 8562, Japan
    Cancer Sci 99:497-501. 2008
    ..and GST-P gene expression is regulated by a transcription factor, nuclear factor-erythroid 2-related factor 2 (Nrf2)...
  93. doi Zinc protects endothelial cells from hydrogen peroxide via Nrf2-dependent stimulation of glutathione biosynthesis
    Miriam M Cortese
    Institute of Molecular Medicine, Research Group Immunobiology, Medical Faculty of the Heinrich Heine University Düsseldorf, Universitatsstrasse 1, D 40225 Dusseldorf, Germany
    Free Radic Biol Med 44:2002-12. 2008
    ..silencing technique, we found that zinc upregulates the expression of GCLC by activating the transcription factor Nrf2. Surprisingly, the intracellular zinc sensor, metal-responsive transcription factor-1, is not involved in the zinc-..
  94. pmc Decline in NRF2-regulated antioxidants in chronic obstructive pulmonary disease lungs due to loss of its positive regulator, DJ-1
    Deepti Malhotra
    Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Room E7624, 615 North Wolfe St, Baltimore, MD 21205, USA
    Am J Respir Crit Care Med 178:592-604. 2008
    ..b>NRF2, a redox-sensitive transcription factor, dissociates from its inhibitor, KEAP1, to induce antioxidant expression ..
  95. doi Altered Nrf2/Keap1-Bach1 equilibrium in pulmonary emphysema
    D Goven
    INSERM U700, Faculté de Médecine Paris 7, Site X Bichat, BP416, 75870 Paris Cedex 18, France
    Thorax 63:916-24. 2008
    ..1 (NQO1), results from an equilibrium created by positive or negative regulation by the transcription factors Nrf2, Keap1 and Bach1, respectively...
  96. doi Adaptive HNE-Nrf2-HO-1 pathway against oxidative stress is associated with acute gastric mucosal lesions
    Kazuki Ueda
    Second Department of Internal Medicine, Wakayama Medical University, 811 1 Kimiidera, Wakayama City 641 8509, Japan
    Am J Physiol Gastrointest Liver Physiol 295:G460-9. 2008
    ..mediator of the oxidative response array, 4-hydroxynonenal (HNE), transcriptional factor, NF-E2-related factor (Nrf2), and the inducible heme oxygenase (HO-1) in the injured stomach...
  97. doi Traumatic brain injury induces the activation of the Nrf2-ARE pathway in the lung in rats
    Wei Yan
    Department of Neurosurgery, Jinling Hospital, School of Medicine, Nanjing University, Nanjing, Jiangsu Province, PR China
    Brain Inj 22:802-10. 2008
    Acute lung injury (ALI) is a frequent but poorly understood complication of traumatic brain injury (TBI). The Nrf2-ARE pathway has been proved to be essential for protection against diffuse inflammation and oxidative damage, which are ..
  98. pmc Mutant huntingtin activates Nrf2-responsive genes and impairs dopamine synthesis in a PC12 model of Huntington's disease
    Willeke M C van Roon-Mom
    Center for Human and Clinical Genetics, Leiden, The Netherlands
    BMC Mol Biol 9:84. 2008
    ..mRNA changes were studied in an inducible PC12 model of Huntington's disease, before and after aggregates became visible, to identify groups of genes that could play a role in the early pathology of Huntington's disease...
  99. doi Genetic ablation of Nrf2 enhances susceptibility to acute lung injury after traumatic brain injury in mice
    Wei Jin
    Department of Neurosurgery, Jinling Hospital, School of Medicine, Nanjing University, 305 East Zhongshan Road, Nanjing 210002, Jiangsu Province, PR China
    Exp Biol Med (Maywood) 234:181-9. 2009
    Previous studies have shown that nuclear factor erythroid 2-related factor 2 (Nrf2) plays a unique role in many physiological stress processes...
  100. doi Identification and characterization of an Nrf2-mediated ARE upstream of the rat glutamate cysteine ligase catalytic subunit gene (GCLC)
    Muyao Li
    Department of Medicine, University of Vermont College of Medicine, Burlington, Vermont 05405, USA
    J Cell Biochem 107:944-54. 2009
    ..NF-E2-related factor 2 (Nrf2) is a principal transcription factor that binds to the ARE and plays a key role in cellular responses to stress via ..
  101. pmc Neuroprotective effects of the triterpenoid, CDDO methyl amide, a potent inducer of Nrf2-mediated transcription
    Lichuan Yang
    Department of Neurology and Neuroscience, Weill Medical College of Cornell University, New York Presbyterian Hospital, New York, NY, USA
    PLoS ONE 4:e5757. 2009
    The NF-E2-related factor-2 (Nrf2)/antioxidant response element (ARE) signaling pathway regulates phase 2 detoxification genes, including a variety of antioxidative enzymes...

Research Grants1

  1. Pediatric Severe Asthma: Role of Oxidant Stress and Alveolar Macrophage Function
    Anne Fitzpatrick; Fiscal Year: 2009
    ..This proposal will lay the foundation for further studies, and the mechanisms identified may ultimately be targeted in future interventional trials. ..