Nfat5

Summary

Gene Symbol: Nfat5
Description: nuclear factor of activated T-cells 5
Alias: NF-AT5, Nfat, TonEBP, nuclear factor of activated T-cells 5, T-cell transcription factor NFAT5, nuclear factor of activated T-cells 5, tonicity-responsive
Species: rat

Top Publications

  1. pmc c-Abl mediates high NaCl-induced phosphorylation and activation of the transcription factor TonEBP/OREBP
    Morgan Gallazzini
    Laboratory of Kidney and Electrolyte Metabolism, National Heart Lung and Blood Institute, Bethesda, MD 20892 1603
    FASEB J 24:4325-35. 2010
  2. doi NFAT5 protects astrocytes against oxygen-glucose-serum deprivation/restoration damage via the SIRT1/Nrf2 pathway
    Xun Xia
    Department of Neurological Surgery, Chengdu Military General Hospital, Chengdu, 610083, China
    J Mol Neurosci 61:96-104. 2017
  3. doi Regional heterogeneity of expression of renal NPRs, TonEBP, and AQP-2 mRNAs in rats with acute kidney injury
    Seung Ah Cha
    Department of Physiology, Chonbuk National University Medical School, Jeonju, Republic of Korea
    Peptides 69:33-9. 2015
  4. doi NFAT5-dependent expression of AQP4 in astrocytes
    Min Hee Yi
    Department of Anatomy, Brain Research Institute, Chungnam National University School of Medicine, Daejeon, South Korea
    Cell Mol Neurobiol 33:223-32. 2013
  5. pmc NFAT5 is activated by hypoxia: role in ischemia and reperfusion in the rat kidney
    Sandra Villanueva
    Laboratory of Molecular Physiology, Faculty of Medicine, Universidad de Los Andes, Santiago Chile
    PLoS ONE 7:e39665. 2012
  6. ncbi Galpha12/13-mediated up-regulation of TRPC6 negatively regulates endothelin-1-induced cardiac myofibroblast formation and collagen synthesis through nuclear factor of activated T cells activation
    Motohiro Nishida
    Department of Pharmacology and Toxicology, Graduate School of Pharmaceutical Sciences, Kyushu University, 3 1 1 Maidashi, Fukuoka 812 8582, Japan
    J Biol Chem 282:23117-28. 2007
  7. pmc Activation of TonEBP by calcium controls {beta}1,3-glucuronosyltransferase-I expression, a key regulator of glycosaminoglycan synthesis in cells of the intervertebral disc
    Akihiko Hiyama
    Department of Orthopedic Surgery, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    J Biol Chem 284:9824-34. 2009
  8. pmc Osmolarity and intracellular calcium regulate aquaporin2 expression through TonEBP in nucleus pulposus cells of the intervertebral disc
    Sachin Gajghate
    Department of Orthopaedic Surgery, Thomas Jefferson University, 1015 Walnut Street, Philadelphia, PA 19107, USA
    J Bone Miner Res 24:992-1001. 2009
  9. pmc Nuclear factor of activated T cells 5 regulates vascular smooth muscle cell phenotypic modulation
    Julia A Halterman
    Department of Pharmacology, Robert M Berne Cardiovascular Research Center, University of Virginia, Charlottesville, USA
    Arterioscler Thromb Vasc Biol 31:2287-96. 2011
  10. pmc High NaCl-induced activation of CDK5 increases phosphorylation of the osmoprotective transcription factor TonEBP/OREBP at threonine 135, which contributes to its rapid nuclear localization
    Morgan Gallazzini
    Laboratory of Kidney and Electrolyte Metabolism, National Heart, Lung, and Blood Institute, Bethesda, MD 20892, USA
    Mol Biol Cell 22:703-14. 2011

Scientific Experts

  • Zheng Zhang
  • Ryoji Kojima
  • Takashi Ito
  • Morgan Gallazzini
  • H Moo Kwon
  • Irving M Shapiro
  • Makarand V Risbud
  • Tsung Ting Tsai
  • Sachin Gajghate
  • Akihiko Hiyama
  • Xun Xia
  • Seung Ah Cha
  • Min Hee Yi
  • Sandra Villanueva
  • Julia A Halterman
  • Sergio Lavandero
  • Agnes Machnik
  • Jin Kim
  • Daisuke Sakai
  • Mee R Sheen
  • Yu Mi Kim
  • Jeong Ah Kim
  • Paola Navarro
  • Huei Fong Hung
  • Motohiro Nishida
  • Asha Guttapalli
  • Todd J Albert
  • Karl J A McCullagh
  • Yong Qin Kuang
  • Yun ming Li
  • Li Bin Yang
  • Hai Dong Huang
  • Bo Qu
  • Ke Xia Fan
  • Yuan Ma
  • Hui Zheng
  • Jian Wen Gu
  • Won Kim
  • Soo Mi Kim
  • Suhn Hee Kim
  • Yu Jin Jung
  • Kyung Pyo Kang
  • Byung Mun Park
  • Young Sook Lee
  • Soo Jin Kim
  • Sang Do Lee
  • Dong Woon Kim
  • Joon Won Kang
  • Sang Ha Oh
  • Young Ho Lee
  • Yong Min Kim
  • Cristian Suazo
  • Daniela Santapau
  • Juan E Carreño
  • Mariana Quiroz
  • Sebastian Illanes
  • Francisco Perez
  • Carlos E Irarrazabal
  • Luis Michea
  • Brian R Wamhoff
  • Pamela D Schoppee Bortz
  • Ramin Zargham
  • Kai Uwe Eckardt
  • Friedrich C Luft
  • Jens Titze
  • Nico Van Rooijen
  • Dominik N Muller
  • Joon Keun Park
  • Dontscho Kerjaschki
  • Hubertus Wagner
  • Christoph Kopp
  • Anke Dahlmann
  • Jennifer Goss
  • Joji Mochida
  • Soo H Park
  • D Greg Anderson
  • Un S Jeon
  • Wan Young Kim
  • Hyun Wook Lee
  • Monica Shah
  • Janet D Klein
  • Dongun Kim
  • Ju Y Jung
  • Jeff M Sands
  • Sun W Lim
  • Ki H Han
  • Hang Chang
  • Kou Gi Shyu
  • Francisco Moraga
  • Jorge E Jalil

Detail Information

Publications22

  1. pmc c-Abl mediates high NaCl-induced phosphorylation and activation of the transcription factor TonEBP/OREBP
    Morgan Gallazzini
    Laboratory of Kidney and Electrolyte Metabolism, National Heart Lung and Blood Institute, Bethesda, MD 20892 1603
    FASEB J 24:4325-35. 2010
    The transcription factor TonEBP/OREBP promotes cell survival during osmotic stress. High NaCl-induced phosphorylation of TonEBP/OREBP at tyrosine-143 was known to be an important factor in increasing its activity in cell culture...
  2. doi NFAT5 protects astrocytes against oxygen-glucose-serum deprivation/restoration damage via the SIRT1/Nrf2 pathway
    Xun Xia
    Department of Neurological Surgery, Chengdu Military General Hospital, Chengdu, 610083, China
    J Mol Neurosci 61:96-104. 2017
    Nuclear factor of activated T cells (NFAT) is a multifunctional cytokine family. NFAT5 was recently reported to be involved in many neuronal functions, but its specific function remains unclear...
  3. doi Regional heterogeneity of expression of renal NPRs, TonEBP, and AQP-2 mRNAs in rats with acute kidney injury
    Seung Ah Cha
    Department of Physiology, Chonbuk National University Medical School, Jeonju, Republic of Korea
    Peptides 69:33-9. 2015
    ..ME), inner cortex (IC), and outer cortex (OC), respectively, and tonicity-responsive enhancer binding protein (TonEBP), auqaporin-2 (AQP-2) and eNOS mRNAs were highly expressed in ME...
  4. doi NFAT5-dependent expression of AQP4 in astrocytes
    Min Hee Yi
    Department of Anatomy, Brain Research Institute, Chungnam National University School of Medicine, Daejeon, South Korea
    Cell Mol Neurobiol 33:223-32. 2013
    ..regulation for AQP4 under conditions of astrocytic swelling, we examined the role of nuclear factor of activated T cells 5 (NFAT5)...
  5. pmc NFAT5 is activated by hypoxia: role in ischemia and reperfusion in the rat kidney
    Sandra Villanueva
    Laboratory of Molecular Physiology, Faculty of Medicine, Universidad de Los Andes, Santiago Chile
    PLoS ONE 7:e39665. 2012
    The current hypothesis postulates that NFAT5 activation in the kidney's inner medulla is due to hypertonicity, resulting in cell protection...
  6. ncbi Galpha12/13-mediated up-regulation of TRPC6 negatively regulates endothelin-1-induced cardiac myofibroblast formation and collagen synthesis through nuclear factor of activated T cells activation
    Motohiro Nishida
    Department of Pharmacology and Toxicology, Graduate School of Pharmaceutical Sciences, Kyushu University, 3 1 1 Maidashi, Fukuoka 812 8582, Japan
    J Biol Chem 282:23117-28. 2007
    ..participate in sustained Ca(2+) influx required for the activation of nuclear factor of activated T cells (NFAT), a Ca(2+)-responsive transcriptional factor, in rat neonatal cardiac fibroblasts...
  7. pmc Activation of TonEBP by calcium controls {beta}1,3-glucuronosyltransferase-I expression, a key regulator of glycosaminoglycan synthesis in cells of the intervertebral disc
    Akihiko Hiyama
    Department of Orthopedic Surgery, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    J Biol Chem 284:9824-34. 2009
    ..Experiments using TonEBP and DN-TonEBP constructs showed that TonEBP positively regulated GlcAT-I promoter activity...
  8. pmc Osmolarity and intracellular calcium regulate aquaporin2 expression through TonEBP in nucleus pulposus cells of the intervertebral disc
    Sachin Gajghate
    Department of Orthopaedic Surgery, Thomas Jefferson University, 1015 Walnut Street, Philadelphia, PA 19107, USA
    J Bone Miner Res 24:992-1001. 2009
    ..We determined whether AQP2 promoter expression was regulated by osmolarity in a tonicity enhancer binding protein (TonEBP)-dependent manner...
  9. pmc Nuclear factor of activated T cells 5 regulates vascular smooth muscle cell phenotypic modulation
    Julia A Halterman
    Department of Pharmacology, Robert M Berne Cardiovascular Research Center, University of Virginia, Charlottesville, USA
    Arterioscler Thromb Vasc Biol 31:2287-96. 2011
    The tonicity-responsive transcription factor, nuclear factor of activated T cells 5 (NFAT5/tonicity enhancer binding protein [TonEBP]), has been well characterized in numerous cell types; however, NFAT5 function in vascular smooth muscle ..
  10. pmc High NaCl-induced activation of CDK5 increases phosphorylation of the osmoprotective transcription factor TonEBP/OREBP at threonine 135, which contributes to its rapid nuclear localization
    Morgan Gallazzini
    Laboratory of Kidney and Electrolyte Metabolism, National Heart, Lung, and Blood Institute, Bethesda, MD 20892, USA
    Mol Biol Cell 22:703-14. 2011
    When activated by high NaCl, tonicity-responsive enhancer-binding protein/osmotic response element-binding protein (TonEBP/OREBP) increases transcription of osmoprotective genes...
  11. doi Hypertonicity-induced expression of monocyte chemoattractant protein-1 through a novel cis-acting element and MAPK signaling pathways
    Ryoji Kojima
    Laboratory of Analytical Pharmacology, Faculty of Pharmacy, Meijo University, Nagoya 468 8503, Japan
    J Immunol 184:5253-62. 2010
    ..gel mobility shift assay showed a slow migration of the MCP1-TonE/ORE probe, representing the binding of TonEBP/OREBP/NFAT5 to this enhancer element...
  12. doi Mononuclear phagocyte system depletion blocks interstitial tonicity-responsive enhancer binding protein/vascular endothelial growth factor C expression and induces salt-sensitive hypertension in rats
    Agnes Machnik
    Department of Nephrology and Hypertension, Friedrich Alexander University, Erlangen Nurnberg, Germany
    Hypertension 55:755-61. 2010
    ..Failure of this physiological extrarenal regulatory mechanism leads to a salt-sensitive blood pressure response...
  13. ncbi Expression of osmotic stress-related genes in tissues of normal and hyposmotic rats
    Zheng Zhang
    Laboratory of Kidney and Electrolyte Metabolism, National Heart Lung and Blood Institute, Bethesda, MD 20892, USA
    Am J Physiol Renal Physiol 285:F688-93. 2003
    b>TonEBP is a transcription factor that, when activated by hypertonicity, increases transcription of genes, including those involved in organic osmolyte accumulation...
  14. doi Interstitial tonicity controls TonEBP expression in the renal medulla
    Mee R Sheen
    Department of Medicine, University of Maryland, Baltimore, Maryland 21201, USA
    Kidney Int 75:518-25. 2009
    ..kidney medulla, express a transcriptional activator termed tonicity responsive enhancer binding protein (TonEBP)...
  15. doi The molecular regulation of resistin expression in cultured vascular smooth muscle cells under hypoxia
    Huei Fong Hung
    Division of Cardiology, Shin Kong Wu Ho Su Memorial Hospital, Taipei, Taiwan
    J Hypertens 26:2349-60. 2008
    ..We sought to investigate the molecular regulation of resistin expression under hypoxia in cultured vascular smooth muscle cells...
  16. pmc Urea and NaCl regulate UT-A1 urea transporter in opposing directions via TonEBP pathway during osmotic diuresis
    Yu Mi Kim
    Dept of Pediatrics, The Catholic Univ of Korea, Uijeongbu St Mary s Hospital, 65 1 Kumoh Dong, Uijeongbu 480 717, Republic of Korea
    Am J Physiol Renal Physiol 296:F67-77. 2009
    ..In the IM, UT-A1 and UT-A3 urea transporters, CLC-K1 chloride channel, and tonicity-enhanced binding protein (TonEBP) transcription factor were all increased in HSD and decreased in HUD...
  17. pmc Osmotically-induced genes are controlled by the transcription factor TonEBP in cultured cardiomyocytes
    Paola Navarro
    Centro FONDAP de Estudios Moleculares de la Célula, Universidad de Chile, Olivos 1007, Santiago 838 0492, Chile
    Biochem Biophys Res Commun 372:326-30. 2008
    ..Tonicity-responsive enhancer binding protein (TonEBP) is a key transcription factor participating in the adaptation of cells to increases in tonicity...
  18. ncbi MEK/ERK signaling controls osmoregulation of nucleus pulposus cells of the intervertebral disc by transactivation of TonEBP/OREBP
    Tsung Ting Tsai
    Department of Orthopaedic Surgery, Thomas Jefferson University, Philadelphia, Pennsylvania19107, USA
    J Bone Miner Res 22:965-74. 2007
    Earlier studies have shown that intervertebral disc cells express TonEBP, a transcription factor that permits adaptation to osmotic stress and regulates aggrecan gene expression...
  19. ncbi TauT gene expression is regulated by TonEBP and plays a role in cell survival
    Takashi Ito
    Department of Clinical Evaluation of Medicines and Therapeutics, Graduate School of Pharmaceutical Sciences, Osaka University, Osaka, Japan
    Adv Exp Med Biol 583:91-8. 2006
  20. ncbi Degradation of NFAT5, a transcriptional regulator of osmotic stress-related genes, is a critical event for doxorubicin-induced cytotoxicity in cardiac myocytes
    Takashi Ito
    Department of Clinical Pharmacology and Pharmacogenomics, Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Osaka 565 0871, Japan
    J Biol Chem 282:1152-60. 2007
    Nuclear factor-activated T cell 5 (NFAT5), a novel member of the NFAT family of proteins, was originally identified as a transcriptional factor responsible for adaptation to hyperosmotic stress...
  21. ncbi TonEBP/OREBP is a regulator of nucleus pulposus cell function and survival in the intervertebral disc
    Tsung Ting Tsai
    Department of Orthopaedic Surgery, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    J Biol Chem 281:25416-24. 2006
    ..The goal of this investigation was to determine the functional role of the osmo-regulatory protein, TonEBP, in cells of the nucleus pulposus...
  22. pmc NFAT is a nerve activity sensor in skeletal muscle and controls activity-dependent myosin switching
    Karl J A McCullagh
    Department of Biomedical Sciences, Consiglio Nazionale delle Ricerche Institute of Neurosciences, University of Padua, 35121 Padua, Italy
    Proc Natl Acad Sci U S A 101:10590-5. 2004
    ..We have investigated the role of the transcription factor nuclear factor of activated T cells (NFAT), a major target of Cn, by using an in vivo transfection approach in regenerating and adult rat muscles...