Nes

Summary

Gene Symbol: Nes
Description: nestin
Alias: nestin
Species: rat

Top Publications

  1. pmc Heterogeneity of neural progenitor cells revealed by enhancers in the nestin gene
    P J Yaworsky
    Molecular Neuroscience Program, Samuel C Johnson Medical Research Center, Scottsdale, Arizona, 85259, USA
    Dev Biol 205:309-21. 1999
  2. ncbi Evidence for a distinct group of nestin-immunoreactive neurons within the basal forebrain of adult rats
    S Wang
    Department of Anatomy and Neurobiology, Zhongshan Medical College, Sun Yat Sen University, 74 Zhongshan 2nd Road, Guangzhou, 510080 PR China
    Neuroscience 142:1209-19. 2006
  3. ncbi Nestin expression in the kidney with an obstructed ureter
    T Sakairi
    Department of Medicine and Clinical Science, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan
    Kidney Int 72:307-18. 2007
  4. ncbi Resident nestin+ neural-like cells and fibers are detected in normal and damaged rat myocardium
    Viviane El-Helou
    Department of Physiology, University of Montreal, Montreal Heart Institute, Montreal, Quebec, Canada
    Hypertension 46:1219-25. 2005
  5. doi Age-related alterations of Nestin-immunoreactive neurons in rat basal forebrain with aged memory deficit
    Dongpei Li
    Department of Anatomy and Neurobiology, Zhongshan School of Medicine, Sun Yat Sen University, Guangzhou, People s Repiblic of China
    Neurochem Int 53:270-7. 2008
  6. ncbi Nestin expression--a property of multi-lineage progenitor cells?
    C Wiese
    In Vitro Differentiation Group, Institute of Plant Genetics and Crop Plant Research IPK Gatersleben, Corrensstrasse 3, 06466, Gatersleben, Germany
    Cell Mol Life Sci 61:2510-22. 2004
  7. doi Nestin (+) stem cells independently contribute to neural remodelling of the ischemic heart
    Pauline C Beguin
    Research Center, Montreal Heart Institute, Montreal, Quebec, Canada
    J Cell Physiol 226:1157-65. 2011
  8. pmc Cdk5 regulates the organization of Nestin and its association with p35
    Cecilia M Sahlgren
    Department of Biology, Abo Akademi University, BioCity, Finland
    Mol Cell Biol 23:5090-106. 2003
  9. pmc Nestin promotes the phosphorylation-dependent disassembly of vimentin intermediate filaments during mitosis
    Ying Hao Chou
    Department of Cell and Molecular Biology, Northwestern University, 303 East Chicago Avenue, Chicago, IL 60611, USA
    Mol Biol Cell 14:1468-78. 2003
  10. ncbi CNS stem cells express a new class of intermediate filament protein
    U Lendahl
    Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge 02142
    Cell 60:585-95. 1990

Scientific Experts

  • Ilaria Decimo
  • Tae kyun Shin
  • Rainald Schmidt-Kastner
  • J Orendacova
  • L Gautron
  • Angelino Calderone
  • Dongpei Li
  • Yuan Li Huang
  • Hsi Yuan Yang
  • Andreanne Chabot
  • Kai Hua Guo
  • Louis Villeneuve
  • Pauline C Beguin
  • Viviane El-Helou
  • Kai wei Chang
  • Peng Han Su
  • Bu Miin Huang
  • Meei Jyh Jiang
  • Hua Lin Wu
  • Guey Yueh Shi
  • Hsinyu Lee
  • Hugues Gosselin
  • Farhan Saboor
  • Vanessa Hertig
  • Wen Zhang
  • Zong Ruei Wong
  • S Yoshida
  • Yoo Jin Shin
  • Wei Liu
  • Huai Yu Gu
  • Natacha Duquette
  • Zhi Bin Yao
  • O Kutlu
  • Hitoshi Miyako
  • Jianhua Zhu
  • D Abe
  • Yong qian Wang
  • Jocelyn Dupuis
  • Akiko Suzuki
  • Gabriel Luna
  • Ramon Brugada
  • Takeyasu Maeda
  • Kayoko Nozawa-Inoue
  • Xiao Jing Xue
  • Yoshiro Kawano
  • David Vansthertem
  • Dana Cizkova
  • Yasuharu Takamori
  • Takuji Takaoka
  • Rudolph Reimer
  • Mi Hee Park
  • O V Kirik
  • Shion Saito
  • Noriyuki Takahashi
  • Pui Sin Man
  • Lisha Li
  • Taichang Jang
  • Jun Zou
  • Yu Yin Huang
  • Jin Qiao Sun
  • T Sakairi
  • Robert Clement
  • Dong Mei Jia
  • L P Xue
  • Astrid Chamson-Reig
  • Solène Sergent-Tanguy
  • Zhen qiang Zhao
  • M Ishizaki
  • S Wang
  • Hideki Kanaya
  • Yang dong He
  • Olga Krylyshkina
  • C Wiese
  • Ali Abdel-Rahman
  • A G Douen
  • Grigori Enikolopov
  • Dieter Muller
  • Claudia U M Tomczyk
  • Lyse Bissonnette
  • Ying Hao Chou
  • Tatyana V Michurina
  • Andrea Mietens
  • Dorothea M Peters
  • Emmanuelle Brochiero
  • Cecilia M Sahlgren
  • Andre Kaschtanow
  • Elena Boscher
  • Quang Trinh Nguyen
  • Norbert Weissmann
  • Ralf Middendorff

Detail Information

Publications69

  1. pmc Heterogeneity of neural progenitor cells revealed by enhancers in the nestin gene
    P J Yaworsky
    Molecular Neuroscience Program, Samuel C Johnson Medical Research Center, Scottsdale, Arizona, 85259, USA
    Dev Biol 205:309-21. 1999
    ..each requiring the cooperation of at least two independent regulatory sites, within the second intron of the rat nestin gene...
  2. ncbi Evidence for a distinct group of nestin-immunoreactive neurons within the basal forebrain of adult rats
    S Wang
    Department of Anatomy and Neurobiology, Zhongshan Medical College, Sun Yat Sen University, 74 Zhongshan 2nd Road, Guangzhou, 510080 PR China
    Neuroscience 142:1209-19. 2006
    b>Nestin is an intermediate filament protein serving as a marker for neuroprogenitor and stem cells...
  3. ncbi Nestin expression in the kidney with an obstructed ureter
    T Sakairi
    Department of Medicine and Clinical Science, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan
    Kidney Int 72:307-18. 2007
    b>Nestin is an intermediate filament protein originally identified in neuroepithelial stem cells...
  4. ncbi Resident nestin+ neural-like cells and fibers are detected in normal and damaged rat myocardium
    Viviane El-Helou
    Department of Physiology, University of Montreal, Montreal Heart Institute, Montreal, Quebec, Canada
    Hypertension 46:1219-25. 2005
    The present study examined whether nestin+ neural-like stem cells detected in the scar tissue of rats 1 week after myocardial infarction (MI) were derived from bone marrow and/or were resident cells of the normal myocardium...
  5. doi Age-related alterations of Nestin-immunoreactive neurons in rat basal forebrain with aged memory deficit
    Dongpei Li
    Department of Anatomy and Neurobiology, Zhongshan School of Medicine, Sun Yat Sen University, Guangzhou, People s Repiblic of China
    Neurochem Int 53:270-7. 2008
    Age-related and aged memory deficit changes in Nestin-immunoreactive (Nestin-IR) neurons were studied following recent evidence of distinct Nestin-IR neurons within adult rat basal forebrain...
  6. ncbi Nestin expression--a property of multi-lineage progenitor cells?
    C Wiese
    In Vitro Differentiation Group, Institute of Plant Genetics and Crop Plant Research IPK Gatersleben, Corrensstrasse 3, 06466, Gatersleben, Germany
    Cell Mol Life Sci 61:2510-22. 2004
    ..In this review, we describe what is currently known about nestin, an intermediate filament first identified in neuroepithelial stem cells...
  7. doi Nestin (+) stem cells independently contribute to neural remodelling of the ischemic heart
    Pauline C Beguin
    Research Center, Montreal Heart Institute, Montreal, Quebec, Canada
    J Cell Physiol 226:1157-65. 2011
    Recent studies have revealed the existence of multipotent nestin-immunoreactive cells in the adult mammalian heart...
  8. pmc Cdk5 regulates the organization of Nestin and its association with p35
    Cecilia M Sahlgren
    Department of Biology, Abo Akademi University, BioCity, Finland
    Mol Cell Biol 23:5090-106. 2003
    The intermediate filament protein nestin is characterized by its specific expression during the development of neuronal and myogenic tissues...
  9. pmc Nestin promotes the phosphorylation-dependent disassembly of vimentin intermediate filaments during mitosis
    Ying Hao Chou
    Department of Cell and Molecular Biology, Northwestern University, 303 East Chicago Avenue, Chicago, IL 60611, USA
    Mol Biol Cell 14:1468-78. 2003
    The expression of the intermediate filament (IF) protein nestin is closely associated with rapidly proliferating progenitor cells during neurogenesis and myogenesis, but little is known about its function...
  10. ncbi CNS stem cells express a new class of intermediate filament protein
    U Lendahl
    Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge 02142
    Cell 60:585-95. 1990
    ..This gene was named nestin because it is specifically expressed in neuroepithelial stem cells...
  11. doi Identification of nestin as a urinary biomarker for acute kidney injury
    Wen Zhang
    Department of Nephrology, Ruijin Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, PR China
    Am J Nephrol 39:110-21. 2014
    ..Despite the advances in treatment of AKI, many patients still progress to end-stage renal disease and depend on dialysis. Therefore, early diagnosis and adequate treatment of AKI could improve prognosis...
  12. pmc The neurogenic response of cardiac resident nestin(+) cells was associated with GAP43 upregulation and abrogated in a setting of type I diabetes
    Andreanne Chabot
    Montreal Heart Institute, Research Center, 5000 Belanger Street East, Montreal, QC H1T 1C8, Canada
    Cardiovasc Diabetol 12:114. 2013
    Cardiac nestin(+) cells exhibit properties of a neural progenitor/stem cell population characterized by the de novo synthesis of neurofilament-M in response to ischemic injury and 6-hydroxydopamine administration...
  13. doi Rapid transition of NESTIN-expressing dividing cells from PROP1-positive to PIT1-positive advances prenatal pituitary development
    S Yoshida
    Division of Life Science, Graduate School of Agriculture, Meiji University, Kanagawa, Japan
    J Neuroendocrinol 25:779-91. 2013
    ..the present study, we examined the proliferation activities of progenitor cells by indication of the expression of Nestin, a marker of rapidly dividing progenitor cells, aiming to verify our hypothesis and to resolve another outstanding ..
  14. doi Postnatal development of nestin positive neurons in rat basal forebrain: different onset and topography with choline acetyltransferase and parvalbumin expression
    Kai Hua Guo
    Department of Anatomy and Neurobiology, Zhongshan School of Medicine, Sun Yat Sen University, Guangzhou, PR China Department of Anatomy, Xinjiang Medical University, Urumqi, Xinjiang, PR China Electronic address
    Int J Dev Neurosci 35:72-9. 2014
    Our previous studies identified a sub-population of cholinergic neurons which express nestin in the rostral part of the basal forebrain (BF) in normal adult rats...
  15. ncbi Pineal gland expression of the transcription factor Egr-1 is restricted to a population of glia that are distinct from nestin-immunoreactive cells
    Pui Sin Man
    School of Biosciences, Cardiff University, P O Box 911, Museum Avenue, Cardiff, CF10 3US, UK
    J Mol Histol 39:69-75. 2008
    ..We have also demonstrated for the first time an extensive network of nestin-positive cells throughout the adult pineal gland, however these cells do not co-express Egr-1...
  16. doi Endothelial and Epithelial Cell Transition to a Mesenchymal Phenotype Was Delineated by Nestin Expression
    Andreanne Chabot
    Montreal Heart Institute, Universite de Montreal, Montreal, Quebec, Canada
    J Cell Physiol 231:1601-10. 2016
    ..The intermediate filament protein nestin was highly expressed in fibrotic tissue, detected in fibroblasts and participated in proliferation and migration...
  17. doi Nestin-expressing vascular wall cells drive development of pulmonary hypertension
    Farhan Saboor
    Institute of Anatomy and Cell Biology, Justus Liebig University, Giessen, Germany These authors contributed equally
    Eur Respir J 47:876-88. 2016
    b>Nestin, a well-known marker of neuronal stem cells, was recently suggested to characterise stem cell-like progenitors in non-neuronal structures during development and tissue repair...
  18. pmc Identification and cytoprotective function of a novel nestin isoform, Nes-S, in dorsal root ganglia neurons
    Peng Han Su
    Institute of Molecular and Cellular Biology, National Taiwan University, Taipei 10617, Taiwan
    J Biol Chem 288:8391-404. 2013
    In this study, the first nestin isoform, Nes-S, was identified in neurons of dorsal root ganglia (DRG) of adult rats. Nes-S cannot form filaments by itself in cytoplasmic intermediate filament-free SW13 cells...
  19. doi Altered gene expression in leukocyte transendothelial migration and cell communication pathways in periodontitis-affected gingival tissues
    D Abe
    Division of Periodontology, Department of Oral Biological Science, Niigata University Graduate School of Medical and Dental Sciences, Japan
    J Periodontal Res 46:345-53. 2011
    ..The aims of the present study were to identify the expression of specific genes and biological pathways in periodontitis-affected gingival tissue using microarray and quantitative real-time RT-PCR analyses...
  20. ncbi [Protective effects of Chinese herbal medicine Zuogui Pill on retina ganglion cells after optical nerve clipping injury in rats]
    Yong qian Wang
    Department of Neurosurgery, Shanghai University of Traditional Chinese Medicine, Shanghai, China
    Zhong Xi Yi Jie He Xue Bao 9:991-7. 2011
    ..To investigate the protective effects of Zuogui Pill (ZGP), a compound Chinese herbal medicine, on retina ganglion cells (RGCs) in rats after optical nerve clipping injury...
  21. pmc Increased expression of nestin in the major pelvic ganglion following cavernous nerve injury
    O Kutlu
    The James Buchanan Brady Urological Institute, Department of Urology, Johns Hopkins Medical Institutions, Baltimore, MD, USA
    Int J Impot Res 24:84-90. 2012
    ..identify neuronal repair mechanisms of the major pelvic ganglion (MPG), we evaluated changes in the expression of nestin, an intermediate filament protein and neural stem cell marker following cavernous nerve crush injury (CNI)...
  22. pmc Nestin- and doublecortin-positive cells reside in adult spinal cord meninges and participate in injury-induced parenchymal reaction
    Ilaria Decimo
    Department of Public Health and Community Medicine, Section of Pharmacology, University of Verona, Verona, Italy
    Stem Cells 29:2062-76. 2011
    ..population of cells resident in the adult rat spinal cord meninges that express the neural stem/precursor markers nestin and doublecortin...
  23. pmc The nestin-expressing and non-expressing neurons in rat basal forebrain display different electrophysiological properties and project to hippocampus
    Jianhua Zhu
    Department of Anatomy and Neurobiology, Zhongshan School of Medicine, Sun Yat Sen University, Guangzhou, China
    BMC Neurosci 12:129. 2011
    b>Nestin-immunoreactive (nestin-ir) neurons have been identified in the medial septal/diagonal band complex (MS/DBB) of adult rat and human, but the significance of nestin expression in functional neurons is not clear...
  24. doi The expression of intermediate filament protein nestin and its association with cyclin-dependent kinase 5 in the glomeruli of rats with diabetic nephropathy
    Wei Liu
    Department of Pathology, Hebei Medical University, Shijiazhuang, China
    Am J Med Sci 345:470-7. 2013
    ..The aim of this study was to investigate whether nestin, a cytoskeleton-associated intermediate filament protein, is involved in the development of DN.
  25. doi Characterization of nestin expression and vessel association in the ischemic core following focal cerebral ischemia in rats
    Yoo Jin Shin
    Department of Anatomy, College of Medicine, The Catholic University of Korea, 505 Banpo Dong, Socho gu, Seoul, 137 701, South Korea
    Cell Tissue Res 351:383-95. 2013
    The present study aimed to provide a detailed characterization of the cellular phenotypes of nestin-positive cells in a rat model of ischemic stroke. Nestin-positive cells included reactive astrocytes in the peri-infarct region...
  26. doi Fibroblast growth factor-2 up-regulates the expression of nestin through the Ras-Raf-ERK-Sp1 signaling axis in C6 glioma cells
    Kai wei Chang
    Institute of Molecular and Cellular Biology, National Taiwan University, Taipei 106, Taiwan
    Biochem Biophys Res Commun 434:854-60. 2013
    b>Nestin is a 240-kDa intermediate filament protein expressed mainly in neural and myogenic stem cells...
  27. ncbi Expression of neural stem cell marker nestin in the kidney of rats and humans
    O V Kirik
    Department of General and Special Morphology, Institute of Experimental Medicine, Russian Academy of Medical Sciences, Moscow
    Bull Exp Biol Med 147:539-41. 2009
    b>Nestin is present in podocytes of the renal corpuscle in rats and humans. Specific differences manifested in more intensive and widespread expression of nestin by endothelial cells of blood vessels in human kidney.
  28. pmc Expression profiles of nestin and synemin in reactive astrocytes and Müller cells following retinal injury: a comparison with glial fibrillar acidic protein and vimentin
    Gabriel Luna
    Neuroscience Research Institute, Department of Molecular, Cellular, and Developmental Biology, University of California Santa Barbara, Santa Barbara, CA 93106 5060, USA
    Mol Vis 16:2511-23. 2010
    To examine the expression patterns of the intermediate filament (IF) proteins nestin and synemin following retinal injury.
  29. ncbi Nestin expression in hippocampal astrocytes after injury depends on the age of the hippocampus
    Ali Abdel-Rahman
    Medical Research Service, Veterans Affairs Medical Center, Durham, North Carolina, USA
    Glia 47:299-313. 2004
    Analysis of the expression of nestin in reactive astrocytes facilitates quantification of the extent of activation of astrocytes after injury in the mature CNS...
  30. pmc Expression of nestin, vimentin, and NCAM by renal interstitial cells after ischemic tubular injury
    David Vansthertem
    Laboratory of Histology, Faculty of Medicine and Pharmacy, University of Mons, 7000 Mons, Belgium
    J Biomed Biotechnol 2010:193259. 2010
    ..This population was characterized by the coexpression of vimentin and nestin. The density of -Neural Cell Adhesion Molecule (NCAM) positive interstitial cells increased transiently (18-72 ..
  31. doi Nestin is essential for mitogen-stimulated proliferation of neural progenitor cells
    Xiao Jing Xue
    Institute of Neuroscience and State Key Laboratory of Neuroscience, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
    Mol Cell Neurosci 45:26-36. 2010
    The intermediate filament (IF) protein nestin is a widely accepted molecular marker for neural progenitor cells (NPCs), but its function during neurogenesis remains largely unknown...
  32. doi Chemical identification of nestin-immunoreactive neurons in the rat basal forebrain: a re-examination
    Kai Hua Guo
    Department of Anatomy and Neurobiology, Zhongshan School of Medicine, Sun Yat Sen University, 74 Zhongshan 2nd Road, Guangzhou, 510080, PR China
    Neurochem Int 56:694-702. 2010
    This study explores recently identified neurons that express the protein nestin in the medial septum-diagonal band of Broca (MS-DBB) of adult rats and humans...
  33. doi Neuronal re-juvenilization in the nucleus ambiguus after vagal nerve injury
    Takuji Takaoka
    Department of Otolaryngology Head and Neck Surgery, Keio University School of Medicine, 35 Shinanomachi, Shinjuku, Tokyo 1608582, Japan
    Neurosci Res 65:353-9. 2009
    b>Nestin is an intermediate filament expressed in immature cells in the CNS including neural stem/progenitor cells, reactive astrocytes and immature neurons in lesser amounts after injury...
  34. doi The phenotype and potential origin of nestin+ cardiac myocyte-like cells following infarction
    Pauline C Beguin
    J Appl Physiol (1985) 107:1241-8. 2009
    b>Nestin+ cardiac myocyte-like cells were detected in the peri-infarct/infarct region of the ischemically damaged heart...
  35. pmc Phenotypes of articular disc cells in the rat temporomandibular joint as demonstrated by immunohistochemistry for nestin and GFAP
    Hitoshi Miyako
    Division of Oral Anatomy, Niigata University Graduate School of Medical and Dental Sciences, Japan
    J Anat 219:472-80. 2011
    ..In this immunocytochemical study we examined the localization and distribution patterns of nestin and glial fibrillary acidic protein (GFAP) in the articular disc of the rat temporomandibular joint at postnatal ..
  36. ncbi Ependyma as a possible morphological basis of ischemic preconditioning tolerance in rat spinal cord ischemia model: nestin and Fluoro-Jade B observations
    Judita Orendacova
    Institute of Neurobiology, Slovak Academy of Sciences, Kogice, Slovak Republic
    Cell Mol Neurobiol 24:477-89. 2004
    ..our hypothesis that a transient nonlethal ischemic insult benefits the lumbosacral spinal cord ischemic injury, nestin, the marker of proliferating cells, and Fluoro-Jade B, the marker of degenerating cells, were used in rats...
  37. ncbi Regulation of nestin expression after cortical ablation in adult rat brain
    A G Douen
    Trillium Medical Centre, Mississauga, Ontario, Canada
    Brain Res 1008:139-46. 2004
    During embryogenesis, transient expression of nestin in proliferating neuroepithelial stem cells signals the commitment of progenitor cells to differentiate...
  38. ncbi Embryonic intermediate filaments, nestin and vimentin, expression in the spinal cords of rats with experimental autoimmune encephalomyelitis
    Tae kyun Shin
    Department of Veterinary Medicine, College of Agriculture and Life Sciences, Cheju National University, Jeju, Korea
    J Vet Sci 4:9-13. 2003
    Intermediate filaments, including nestin and vimentin, are found in specific cell types in central nervous system (CNS) tissues, particularly immature glial cells and multipotent progenitor cells...
  39. ncbi Enhancement of nestin protein-immunoreactivity induced by ionizing radiation in the forebrain ependymal regions of rats
    Mei Shi
    Department of Radiotherapy, Xijing Hospital, The Fourth Military Medical University, Xi an 710032, PR China
    Neurosci Res 44:475-81. 2002
    Expression of nestin was immunohistochemically examined in the forebrains of rats receiving ionizing radiation. Nestin-immunoreactive cells were predominately distributed in ependymal regions...
  40. ncbi Nestin immunoreactivity in local neurons of the adult rat striatum after remote cortical injury
    Tatsuya Kuroda
    Department of Neurosurgery, Gifu University School of Medicine, Japan
    J Chem Neuroanat 24:137-46. 2002
    b>Nestin is a marker for the neuronal and glial precursor cells and is expressed in reactive astrocytes after brain injury...
  41. ncbi Nestin expression in pancreatic stellate cells and angiogenic endothelial cells
    Jessy Lardon
    Cell Differentiation Unit, Diabetes Research Center, Free University of Brussels VUB, Laarbeeklaan 103, Belgium
    Histochem Cell Biol 117:535-40. 2002
    b>Nestin is an intermediate filament protein expressed by neuroepithelial stem cells and which has been proposed to represent also a marker for putative islet stem cells...
  42. ncbi Nestin expression persists in astrocytes of organotypic slice cultures from rat cortex
    Rainald Schmidt-Kastner
    Department of Neurology D4 5, University of Miami School of Medicine, P O Box 016960, Miami, FL 33101, USA
    Int J Dev Neurosci 20:29-38. 2002
    b>Nestin is an intermediate filament protein typical for neural precursor cells that is down-regulated in the post-natal rodent brain. Re-expression of nestin has been observed in reactive astrocytes after injury...
  43. doi Coexpression of Pdx1 and betacellulin in mesenchymal stem cells could promote the differentiation of nestin-positive epithelium-like progenitors and pancreatic islet-like spheroids
    Lisha Li
    College of Life Sciences, Peking University, Beijing, People s Republic of China
    Stem Cells Dev 17:815-23. 2008
    ..Coexpression of Pdx1 and BTC significantly increased the number of nestin-positive epithelium-like progenitors and islet-like spheroids which differentiated from MSCs...
  44. ncbi Nestin expression in Müller glial cells in postnatal rat retina and its upregulation following optic nerve transection
    L P Xue
    Department of Anatomy, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597
    Neuroscience 143:117-27. 2006
    This study examined the nestin immunoexpression and its specific cellular localization in the developing retina of rats and investigated its putative changes in an altered environment...
  45. ncbi Long-lasting coexpression of nestin and glial fibrillary acidic protein in primary cultures of astroglial cells with a major participation of nestin(+)/GFAP(-) cells in cell proliferation
    Solène Sergent-Tanguy
    INSERM, U643, Nantes, France
    J Neurosci Res 83:1515-24. 2006
    b>Nestin, a currently used marker of neural stem cells, is transiently coexpressed with glial fibrillary acidic protein (GFAP) during development and is induced in reactive astrocytes following brain injury...
  46. ncbi Altered pancreatic morphology in the offspring of pregnant rats given reduced dietary protein is time and gender specific
    Astrid Chamson-Reig
    Lawson Health Research Institute, St Joseph s Health Care, 268 Grosvenor Street Room H404, London, Ontario, Canada N6A 4V2
    J Endocrinol 191:83-92. 2006
    ..Pancreatic expression of nestin mRNA, and the abundance of nestin-immunoreactive cells within islets, was decreased by all LP treatments...
  47. ncbi [EphB2-Fc promotes activation of endogenous neural stem cells after cerebral cortex infarction: experimental with hypertensive rats]
    Yang dong He
    Stroke Center, Department of Neurology, First Affiliated Hospital, Sun Yat Sen University, Guangzhou 510080, China
    Zhonghua Yi Xue Za Zhi 85:2395-9. 2005
    ..To explore the effects of intraventricular injection of EphB2-Fc on activation of inherent neural stem cells after cerebral cortex infarction...
  48. ncbi Desipramine activated Bcl-2 expression and inhibited lipopolysaccharide-induced apoptosis in hippocampus-derived adult neural stem cells
    Yu Yin Huang
    Department of Anesthesiology, Taipei Veterans General Hospital and National Yang Ming University, Taiwan
    J Pharmacol Sci 104:61-72. 2007
    ..First, we demonstrated that the expression of Bcl-2 mRNA and nestin in 2 microM DP-treated NSCs were up-regulated and detected by real-time reverse transcriptase polymerase chain ..
  49. ncbi [Effect of electroacupuncture on expression of nestin protein after focal ischemia/reperfusion in rats]
    Zhen qiang Zhao
    Department of Neurology, The First Affiliated Hospital, Chongqing University of Medical Sciences, Chongqing 400016
    Zhongguo Zhong Xi Yi Jie He Za Zhi 26:20-4. 2006
    ..To investigate the effect of electroacupuncturing (EA) Hegu point (LI 4) on proliferation of neural stem cells in the subventricular zone (SVZ) after rat focal ischemia/reperfusion (I/R)...
  50. ncbi Time course of expression of intermediate filament protein vimentin, nestin and desmin in rat renal glomerular injury
    Jun Zou
    Department of Pharmacy, School of Medical Sciences, Xiamen University, Xiamen 361005, China
    Chin Med J (Engl) 120:1203-5. 2007
  51. ncbi Fhos2, a novel formin-related actin-organizing protein, probably associates with the nestin intermediate filament
    Hideki Kanaya
    Medical Institute of Bioregulation, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Genes Cells 10:665-78. 2005
    ..Consistent with this, Fhos2 localizes to the nestin intermediate filament but not to other cytoskeletons, as demonstrated by staining of H9c2 (2-1) cells with anti-..
  52. ncbi [Neuroprotective effects of exogenous basic fibroblast growth factor on the hypoxic-ischemic brain damage of neonatal rats]
    Jin Qiao Sun
    Department of Neonatology, the Affiliated Hospital of Zunyi Medical College, Zunyi 563003, China
    Zhonghua Er Ke Za Zhi 45:354-9. 2007
    ..To investigate the neuroprotective effect of basic fibroblast growth factor (bFGF) on neurological function after hypoxic-ischemic brain damage (HIBD) in neonatal rats...
  53. ncbi Expression of nestin in rat and human glomerular podocytes
    M Ishizaki
    Department of Pathology I, Nippon Medical School, Tokyo, Japan
    J Submicrosc Cytol Pathol 38:193-200. 2006
    b>Nestin is a neuroepithelial precursor cell marker expressed in a variety of human cell types during development. However, no information exists on the expression of nestin in mature glomeruli as well as during the glomerular development...
  54. ncbi Human chorionic gonadotropin induces nestin expression in endothelial cells of the ovary via vascular endothelial growth factor signaling
    Noriyuki Takahashi
    Department of Obstetrics and Gynecology, St Marianna University School of Medicine, Sugao, Miyamae ku, Kawasaki 216 8511, Japan
    Endocrinology 149:253-60. 2008
    The intermediate filament protein nestin was originally found to be expressed in neuronal progenitor cells, but recent studies have shown that other cell types, including endocrine and vascular endothelial cells, express nestin...
  55. doi A distinct phenotypic change in gliomas at the time of magnetic resonance imaging detection
    Taichang Jang
    Department of Neurology, Stanford University Medical School, Stanford, California 94305, USA
    J Neurosurg 108:782-90. 2008
    ..The authors recently reported the presence of 2 distinct cellular subsets, 1 expressing nestin and the other both glial fibrillary acidic protein (GFAP) and osteopontin (OPN), within all examined gliomas that ..
  56. ncbi [Relationship between expression of nestin in experimental brain contusion and injury time]
    Dong Mei Jia
    Department of Forensic Pathology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
    Fa Yi Xue Za Zhi 22:161-4. 2006
    To observe the alteration of nestin intervals in the experimental traumatic brain injury and investigate its relation to the injury intervals.
  57. ncbi Nestin-immunoreactive cells in rat pituitary are neither hormonal nor typical folliculo-stellate cells
    Olga Krylyshkina
    Laboratory of Cell Pharmacology, Department of Molecular Cell Biology, University of Leuven, Campus Gasthuisberg, B 3000 Leuven, Belgium
    Endocrinology 146:2376-87. 2005
    b>Nestin is an intermediate filament protein that has originally been identified as a marker of neuroepithelial stem/progenitor cells...
  58. doi Epidermal growth factor up-regulates the expression of nestin through the Ras-Raf-ERK signaling axis in rat vascular smooth muscle cells
    Yuan Li Huang
    Institute of Molecular and Cellular Biology, National Taiwan University, No 1, Sec 4, Roosevelt Road, Taipei 106, Taiwan
    Biochem Biophys Res Commun 377:361-6. 2008
    ..In this study, we showed that nestin, an intermediate filament protein, is expressed in primary cultures of rat VSMCs representing the synthetic ..
  59. doi Expression of nestin, desmin and vimentin in intact and regenerating muscle spindles of rat hind limb skeletal muscles
    Dana Cizkova
    Department of Histology and Embryology, Faculty of Medicine in Hradec Kralove, Charles University in Prague, Simkova 870, Hradec Kralove, 500 38, Czech Republic
    Histochem Cell Biol 131:197-206. 2009
    We describe the expression and distribution patterns of nestin, desmin and vimentin in intact and regenerating muscle spindles of the rat hind limb skeletal muscles...
  60. doi Immunohistochemical detection of nestin in the periodontal Ruffini endings of the rat incisor
    Shion Saito
    Division of Reconstructive Surgery for Oral and Maxillofacial Region, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Neurosci Lett 449:195-200. 2009
    b>Nestin is an intermediate filament which was first identified in neuroepithelial stem cells. This expression has also been reported in restricted locations in adults...
  61. doi Thrombin induces nestin expression via the transactivation of EGFR signalings in rat vascular smooth muscle cells
    Yuan Li Huang
    Institute of Molecular and Cellular Biology, National Taiwan University, No 1 Sec 4 Roosevelt Road, Taipei 106, Taiwan
    Cell Signal 21:954-68. 2009
    Regulation of nestin gene expression is largely unknown despite that it is widely used as a progenitor cell marker...
  62. doi Nestin-positive microglia in adult rat cerebral cortex
    Yasuharu Takamori
    Department of Anatomy and Cell Science, Kansai Medical University, 10 15 Fumizono cho, Moriguchi, Osaka 570 8506, Japan
    Brain Res 1270:10-8. 2009
    b>Nestin is a class VI intermediate filament protein, which was first identified in the early developmental stages of the nervous system. It is widely used as a stem or progenitor cell marker...
  63. doi Nestin serves as a prosurvival determinant that is linked to the cytoprotective effect of epidermal growth factor in rat vascular smooth muscle cells
    Yuan Li Huang
    Institute of Molecular and Cellular Biology, National Taiwan University, No 1, Sec 4, Roosevelt Road, Taipei 106, Taiwan
    J Biochem 146:307-15. 2009
    b>Nestin is an intermediate filament protein mainly expressed in muscle and neural progenitors...
  64. doi Age-related changes in nestin immunoreactivity in the rat pituitary gland
    Laurent Gautron
    Psychoneuroimmunologie, Nutrition et Genetique, INRA UMR 1286, CNRS UMR 5226, Universite Bordeaux 2, Bordeaux, France
    Neuroendocrinology 90:19-30. 2009
    ..The intermediate filament nestin plays a crucial role in cells that retain plasticity during development, aging and tumorigenesis...
  65. doi Chemokines released from astrocytes promote chemokine receptor 5-mediated neuronal cell differentiation
    Mi Hee Park
    College of Pharmacy and Medical Research Center, Chungbuk National University, 48, Gaesin dong, Heungduk gu, Cheongju, Chungbuk 361 763, Republic of Korea
    Exp Cell Res 315:2715-26. 2009
    ..Bradykinin elevated calcium influx in the embryonic neuronal cells. These data suggest that specific chemokines derived from astrocytes may significantly have influence on the CCR5-mediated differentiation of embryonic neuronal cells...
  66. pmc Nestin modulates glucocorticoid receptor function by cytoplasmic anchoring
    Rudolph Reimer
    Heinrich Pette Institute for Experimental Virology and Immunology at the University of Hamburg, Hamburg, Germany
    PLoS ONE 4:e6084. 2009
    b>Nestin is the characteristic intermediate filament (IF) protein of rapidly proliferating progenitor cells and regenerating tissue. Nestin copolymerizes with class III IF-proteins, mostly vimentin, into heteromeric filaments...