Ncstn

Summary

Gene Symbol: Ncstn
Description: nicastrin
Alias: nicastrin
Species: rat

Top Publications

  1. ncbi Mammalian APH-1 interacts with presenilin and nicastrin and is required for intramembrane proteolysis of amyloid-beta precursor protein and Notch
    Sheu Fen Lee
    Center for Basic Neuroscience and Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9111, USA
    J Biol Chem 277:45013-9. 2002
  2. ncbi Presenilin-1, nicastrin, amyloid precursor protein, and gamma-secretase activity are co-localized in the lysosomal membrane
    Stephen H Pasternak
    Research Institute, The Hospital for Sick Children, University of Toronto, Toronto M5G 1X8, Canada
    J Biol Chem 278:26687-94. 2003
  3. ncbi Nicastrin, presenilin, APH-1, and PEN-2 form active gamma-secretase complexes in mitochondria
    Camilla A Hansson
    Karolinska Institutet and Sumitomo Pharmaceuticals Alzheimer Center KASPAC, Neurotec, Novum, SE 141 57 Huddinge, Sweden
    J Biol Chem 279:51654-60. 2004
  4. doi Erlin-2 is associated with active γ-secretase in brain and affects amyloid β-peptide production
    Yasuhiro Teranishi
    Karolinska Institutet Dainippon Sumitomo Pharma Alzheimer Center, KI Alzheimer Disease Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Novum, Stockholm SE 141 86, Sweden
    Biochem Biophys Res Commun 424:476-81. 2012
  5. pmc Down-regulation of the ATP-binding cassette transporter 2 (Abca2) reduces amyloid-β production by altering Nicastrin maturation and intracellular localization
    Vasiliki Michaki
    Center for Human Genetics and Leuven Institute for Neurodegenerative Diseases, KU Leuven, 3000 Leuven, Belgium
    J Biol Chem 287:1100-11. 2012
  6. pmc Proteomic and metabolomic analyses of mitochondrial complex I-deficient mouse model generated by spontaneous B2 short interspersed nuclear element (SINE) insertion into NADH dehydrogenase (ubiquinone) Fe-S protein 4 (Ndufs4) gene
    Dillon W Leong
    Molecular Medicine Division, Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia
    J Biol Chem 287:20652-63. 2012
  7. pmc Association of gamma-secretase with lipid rafts in post-Golgi and endosome membranes
    Kulandaivelu S Vetrivel
    Department of Neurobiology, Pharmacology and Physiology, The University of Chicago, Illinois 60637, USA
    J Biol Chem 279:44945-54. 2004
  8. ncbi Rat nicastrin gene: cDNA isolation, mRNA variants and expression pattern analysis
    Annamaria Confaloni
    Department of Cellular Biology and Neuroscience, Istituto Superiore di Sanita, 299 Viale Regina Elena, 00161 Rome, Italy
    Brain Res Mol Brain Res 136:12-22. 2005
  9. ncbi Normal distribution of presenilin-1 and nicastrin in skeletal muscle and the differential responses of these proteins after denervation
    Kunihiro Sakuma
    Health Science Center, Toyohashi University of Technology, 1 1, Hibarigaoka, Tenpaku cho, Toyohashi 441 8580, Japan
    Biochim Biophys Acta 1760:980-7. 2006
  10. pmc Cellular distribution of gamma-secretase subunit nicastrin in the developing and adult rat brains
    A Kodam
    Department of Psychiatry, University of Alberta, Edmonton, Alberta, Canada
    Neurobiol Aging 29:724-38. 2008

Scientific Experts

  • Kunihiro Sakuma
  • Ulla Maj Fiuza
  • Vasiliki Michaki
  • Dillon W Leong
  • Yasuhiro Teranishi
  • Bengt Winblad
  • A Kodam
  • Lars O Tjernberg
  • Susanne Frykman
  • Annamaria Confaloni
  • Camilla A Hansson
  • Kulandaivelu S Vetrivel
  • Stephen H Pasternak
  • Sheu Fen Lee
  • David R Thorburn
  • Adrienne Laskowski
  • Albert Sickmann
  • Roman Chrast
  • Matthew McKenzie
  • Krist l Vennekens
  • Michael T Ryan
  • Francesc X Guix
  • Masood Kamali-Moghaddam
  • Danyelle M Townsend
  • Tina Wahle
  • Carlos G Dotti
  • John B Davis
  • Estelle Arnaud
  • Kenneth D Tew
  • Taizo Ishikawa
  • James J Pitt
  • Fabian Feiguin
  • Melanie Bahlo
  • Anne K Voss
  • Chelsee A Hewitt
  • Rene P Zahedi
  • Belinda Phipson
  • Bart De Strooper
  • Jasper C Komen
  • Gucci Jijuan Gu
  • Gordon K Smyth
  • Gayle M Davey
  • Takahiro Kihara
  • William R Heath
  • Homira Behbahani
  • Colin Dingwall
  • Takeshi Nishimura
  • Ji Yeun Hur
  • Hamish S Scott
  • Sarah A Kinkel
  • Sebastian Munck
  • S Kar
  • K S Vetrivel
  • G Thinakaran
  • Paola Piscopo
  • Gianluigi Forloni
  • Lorenzo Malvezzi Campeggi
  • Diego Albani
  • Alessio Crestini
  • Marco Tartaglia
  • Liana Terreni
  • Huaxi Xu
  • Richard F Cowburn
  • Gopal Thinakaran
  • Haipeng Cheng
  • Mark R Farmery
  • Camilla Nilsberth
  • Sharon E Pursglove
  • Tong Li
  • William Lin
  • Johan Thyberg
  • Nobuyuki Nukina
  • Akira Ito
  • Philip C Wong
  • Takashi Sakurai
  • Maria Ankarcrona
  • Don J Mahuran
  • John W Callahan
  • Brian J Pak
  • Cameron A Ackerley
  • Marianne Guiral
  • Richard D Bagshaw
  • Sunqu Zhang
  • Cong Yu
  • Sanjiv Shah
  • Hongqiao Li
  • Weiping Han
  • Gang Yu

Detail Information

Publications11

  1. ncbi Mammalian APH-1 interacts with presenilin and nicastrin and is required for intramembrane proteolysis of amyloid-beta precursor protein and Notch
    Sheu Fen Lee
    Center for Basic Neuroscience and Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9111, USA
    J Biol Chem 277:45013-9. 2002
    Presenilin and nicastrin are essential components of the gamma-secretase complex that is required for the intramembrane proteolysis of an increasing number of membrane proteins including the amyloid-beta precursor protein (APP) and Notch...
  2. ncbi Presenilin-1, nicastrin, amyloid precursor protein, and gamma-secretase activity are co-localized in the lysosomal membrane
    Stephen H Pasternak
    Research Institute, The Hospital for Sick Children, University of Toronto, Toronto M5G 1X8, Canada
    J Biol Chem 278:26687-94. 2003
    ..Initial studies indicated that final cleavage of APP by the gamma-secretase (a complex containing presenilin and nicastrin) to produce Abeta occurred in the endosomal/lysosomal system...
  3. ncbi Nicastrin, presenilin, APH-1, and PEN-2 form active gamma-secretase complexes in mitochondria
    Camilla A Hansson
    Karolinska Institutet and Sumitomo Pharmaceuticals Alzheimer Center KASPAC, Neurotec, Novum, SE 141 57 Huddinge, Sweden
    J Biol Chem 279:51654-60. 2004
    ..Presenilin forms an active gamma-secretase complex together with Nicastrin (NCT), APH-1, and PEN-2, which among other substrates cleaves the beta-amyloid precursor protein (beta-APP) ..
  4. doi Erlin-2 is associated with active γ-secretase in brain and affects amyloid β-peptide production
    Yasuhiro Teranishi
    Karolinska Institutet Dainippon Sumitomo Pharma Alzheimer Center, KI Alzheimer Disease Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Novum, Stockholm SE 141 86, Sweden
    Biochem Biophys Res Commun 424:476-81. 2012
    ..In summary, we have found a novel brain GSAP, erlin-2, that resides in DRMs and affects Aβ production...
  5. pmc Down-regulation of the ATP-binding cassette transporter 2 (Abca2) reduces amyloid-β production by altering Nicastrin maturation and intracellular localization
    Vasiliki Michaki
    Center for Human Genetics and Leuven Institute for Neurodegenerative Diseases, KU Leuven, 3000 Leuven, Belgium
    J Biol Chem 287:1100-11. 2012
    ..knock-out cells due to the altered levels, post-translational modification, and subcellular localization of Nicastrin. Reduced Abca2 levels in mammalian cells in vitro, in Drosophila melanogaster and in mice resulted in altered γ-..
  6. pmc Proteomic and metabolomic analyses of mitochondrial complex I-deficient mouse model generated by spontaneous B2 short interspersed nuclear element (SINE) insertion into NADH dehydrogenase (ubiquinone) Fe-S protein 4 (Ndufs4) gene
    Dillon W Leong
    Molecular Medicine Division, Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia
    J Biol Chem 287:20652-63. 2012
    ..Metabolomic analysis of the blood by tandem mass spectrometry showed increased hydroxyacylcarnitine species, implying that the CI defect leads to an imbalanced NADH/NAD(+) ratio that inhibits mitochondrial fatty acid β-oxidation...
  7. pmc Association of gamma-secretase with lipid rafts in post-Golgi and endosome membranes
    Kulandaivelu S Vetrivel
    Department of Neurobiology, Pharmacology and Physiology, The University of Chicago, Illinois 60637, USA
    J Biol Chem 279:44945-54. 2004
    ..of all four components of the gamma-secretase complex, namely presenilin 1 (PS1)-derived fragments, mature nicastrin, APH-1, and PEN-2, with cholesterol-rich detergent insoluble membrane (DIM) domains of non-neuronal cells and ..
  8. ncbi Rat nicastrin gene: cDNA isolation, mRNA variants and expression pattern analysis
    Annamaria Confaloni
    Department of Cellular Biology and Neuroscience, Istituto Superiore di Sanita, 299 Viale Regina Elena, 00161 Rome, Italy
    Brain Res Mol Brain Res 136:12-22. 2005
    b>Nicastrin is a type 1 transmembrane glycoprotein that interacts with presenilin, Aph-1, and Pen-2 proteins to form a high molecular complex with gamma secretase activity...
  9. ncbi Normal distribution of presenilin-1 and nicastrin in skeletal muscle and the differential responses of these proteins after denervation
    Kunihiro Sakuma
    Health Science Center, Toyohashi University of Technology, 1 1, Hibarigaoka, Tenpaku cho, Toyohashi 441 8580, Japan
    Biochim Biophys Acta 1760:980-7. 2006
    Presenilin-1 and nicastrin, two components of gamma-secretase associated with Alzheimer's disease plaques, are present in the synapses of the brain and in various peripheral organs, including skeletal muscle...
  10. pmc Cellular distribution of gamma-secretase subunit nicastrin in the developing and adult rat brains
    A Kodam
    Department of Psychiatry, University of Alberta, Edmonton, Alberta, Canada
    Neurobiol Aging 29:724-38. 2008
    b>Nicastrin and presenilin 1 are integral components of the high molecular weight gamma-secretase complexes that regulate proteolytic processing of various type I membrane proteins including amyloid precursor protein and Notch...
  11. ncbi Cell and molecular biology of Notch
    Ulla Maj Fiuza
    Department of Genetics, University of Cambridge, Cambridge CB2 3EH, UK
    J Endocrinol 194:459-74. 2007
    ..In this review, we will describe the multiple roles of Notch and how various factors can regulate Notch signalling...