Ncf1

Summary

Gene Symbol: Ncf1
Description: neutrophil cytosolic factor 1
Alias: Ncf-1, p47phox, neutrophil cytosolic factor 1, neutrophil cytosol factor 1, phagocyte oxidase 47 kDa
Species: rat

Top Publications

  1. pmc Phagocyte-like NADPH oxidase generates ROS in INS 832/13 cells and rat islets: role of protein prenylation
    Ismail Syed
    Dept of Pharmaceutical Sciences, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State Univ, Detroit, MI 48201, USA
    Am J Physiol Regul Integr Comp Physiol 300:R756-62. 2011
  2. doi Positioning of a polymorphic quantitative trait nucleotide in the Ncf1 gene controlling oxidative burst response and arthritis severity in rats
    Malin Hultqvist
    Medical Inflammation Research, C12 BMC, Lund University, Lund, Sweden
    Antioxid Redox Signal 14:2373-83. 2011
  3. ncbi Positional identification of Ncf1 as a gene that regulates arthritis severity in rats
    Peter Olofsson
    Section for Medical Inflammation Research and Department of Cell and Molecular Biology, Solvegatan 19, I11 BMC, Lund University, S 22184 Lund, Sweden
    Nat Genet 33:25-32. 2003
  4. ncbi Inconsistent susceptibility to autoimmunity in inbred LEW rats is due to genetic crossbreeding involving segregation of the arthritis-regulating gene Ncf1
    Peter Olofsson
    Section for Medical Inflammation Research, Lund University, S 22184 Lund, Sweden
    Genomics 83:765-71. 2004
  5. ncbi Immunohistochemical study of p47Phox and gp91Phox distributions in rat brain
    Myeung Ju Kim
    Department of Anatomy, Cheju National University College of Medicine, Ara 1 Dong, Jeju, Jeju do 690 756, South Korea
    Brain Res 1040:178-86. 2005
  6. ncbi Ncf1 (p47phox) polymorphism determines oxidative burst and the severity of arthritis in rats and mice
    Malin Hultqvist
    Section for Medical Inflammation Research, Lund University, Lund, Sweden
    Cell Immunol 233:97-101. 2005
  7. pmc Exercise Training Attenuates Upregulation of p47(phox) and p67(phox) in Hearts of Diabetic Rats
    Neeru M Sharma
    Department of Cellular and Integrative Physiology, University of Nebraska Medical Center, Omaha, NE 68198, USA
    Oxid Med Cell Longev 2016:5868913. 2016
  8. doi Neuroprotective effects of angiotensin II type 1 receptor (AT1-R) blocker via modulating AT1-R signaling and decreased extracellular glutamate levels
    Tomoyoshi Fujita
    Department of Ophthalmology, Kagawa University, Kagawa, Japan
    Invest Ophthalmol Vis Sci 53:4099-110. 2012
  9. ncbi Advanced intercross line mapping of Eae5 reveals Ncf-1 and CLDN4 as candidate genes for experimental autoimmune encephalomyelitis
    Kristina Becanovic
    Department of Clinical Neuroscience, Neuroimmunology Unit, Karolinska Institutet, SE 171 76 Stockholm, Sweden
    J Immunol 176:6055-64. 2006
  10. pmc Cyclophilin A is required for angiotensin II-induced p47phox translocation to caveolae in vascular smooth muscle cells
    Nwe Nwe Soe
    Department of Medicine, Aab Cardiovascular Research Institute, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA
    Arterioscler Thromb Vasc Biol 33:2147-53. 2013

Research Grants

  1. High Dose Alpha Tocopherol and Carotid Atherosclerosis
    Ishwarlal Jialal; Fiscal Year: 2004
  2. CRP, Diabetes, Atherothrombosis
    Ishwarlal Jialal; Fiscal Year: 2010

Scientific Experts

  • Mubeen A Ansari
  • I Jialal
  • Stefania Schiavone
  • Rui Curi
  • Kensaku Maeda
  • K Becanovic
  • Olof Radmark
  • Michael J Glass
  • Peter Olofsson
  • Abbas Mirshafiey
  • Nynke E Hahn
  • Malin Hultqvist
  • Ismail Syed
  • Roland Reinehr
  • Rikard Holmdahl
  • Katarzyna Winiarska
  • Neeru M Sharma
  • Hongwei Kan
  • Dieter Haussinger
  • Stephan Becker
  • Nguyen Huu Tung
  • Matthew R Distasi
  • Saidan Ding
  • Jun Chen
  • Nwe Nwe Soe
  • Pin Lv
  • Tomoyoshi Fujita
  • Andreia Z Chignalia
  • Ken Ichi Serizawa
  • Chandrashekara N Kyathanahalli
  • Jessica A Sipkens
  • Anjaneyulu Kowluru
  • Magali Balteau
  • Giovanna Frazziano
  • L He
  • Yanzhang Li
  • Alexander Huberle
  • Xi sheng Xie
  • Carola Rintisch
  • Xian Cao
  • Lucia R Lopes
  • Susanne Grether-Beck
  • Verena Keitel
  • Miguel del Campo
  • Alejandra Espinosa
  • Michiharu Tanabe
  • Ji Hoon Yu
  • Carlos H C Serezani
  • Myeung Ju Kim
  • Hsiang Chi Meng
  • Eugenia Raichlin
  • Bartosz Sierakowski
  • Brandon Rabeler
  • Mateusz Labudda
  • Dorota Focht
  • Hong Zheng
  • Jolanta M Dzik
  • Aleksandra Owczarek
  • Wojciech Bielecki
  • Lukasz Komorowski
  • Kaushik P Patel
  • Wen Hu
  • Dake Huang
  • Chunyan Wang
  • Yanyan Yin
  • Wangyang Wu
  • Weizu Li
  • Yuchan Wang
  • Yan Liang
  • Yiru Ye
  • Jianjing Yang
  • Xuebao Wang
  • Bicheng Chen
  • Tania Cristina Pithon-Curi
  • Kai Sun
  • Steven J Miller
  • Joseph L Unthank
  • Jiangnan Hu
  • Leping Liu
  • Jing Yu Fan
  • Yukihiro Shoyama
  • Qichuan ZhuGe
  • Jing Yan Han
  • Padmamalini Baskaran
  • Yeonghwan Kim
  • Jin Wang
  • Patrizia Nigro
  • Minxia Zhu
  • Elaine M Smolock
  • Meiyan Jiang

Detail Information

Publications51

  1. pmc Phagocyte-like NADPH oxidase generates ROS in INS 832/13 cells and rat islets: role of protein prenylation
    Ismail Syed
    Dept of Pharmaceutical Sciences, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State Univ, Detroit, MI 48201, USA
    Am J Physiol Regul Integr Comp Physiol 300:R756-62. 2011
    ..Together, our findings suggest a prenylated Ptx-sensitive signaling step couples Rac1 activation in the signaling steps necessary for glucose-mediated generation of ROS in the pancreatic β-cells...
  2. doi Positioning of a polymorphic quantitative trait nucleotide in the Ncf1 gene controlling oxidative burst response and arthritis severity in rats
    Malin Hultqvist
    Medical Inflammation Research, C12 BMC, Lund University, Lund, Sweden
    Antioxid Redox Signal 14:2373-83. 2011
    The Ncf1 gene, encoding the P47(PHOX) protein that regulates production of reactive oxygen species (ROS) by the phagocyte NADPH oxidase (NOX2) complex, is associated with autoimmunity and arthritis severity in rats...
  3. ncbi Positional identification of Ncf1 as a gene that regulates arthritis severity in rats
    Peter Olofsson
    Section for Medical Inflammation Research and Department of Cell and Molecular Biology, Solvegatan 19, I11 BMC, Lund University, S 22184 Lund, Sweden
    Nat Genet 33:25-32. 2003
    ..cloning of the Pia4 QTL in rats, we found that a naturally occurring polymorphism of Ncf1 (encoding neutrophil cytosolic factor 1, a component of the NADPH oxidase complex) regulates arthritis severity...
  4. ncbi Inconsistent susceptibility to autoimmunity in inbred LEW rats is due to genetic crossbreeding involving segregation of the arthritis-regulating gene Ncf1
    Peter Olofsson
    Section for Medical Inflammation Research, Lund University, S 22184 Lund, Sweden
    Genomics 83:765-71. 2004
    We recently identified a single-nucleotide polymorphism in the Ncf1 gene, a component of the NADPH oxidase complex, to be the cause of one of the strongest identified loci for arthritis severity in rats...
  5. ncbi Immunohistochemical study of p47Phox and gp91Phox distributions in rat brain
    Myeung Ju Kim
    Department of Anatomy, Cheju National University College of Medicine, Ara 1 Dong, Jeju, Jeju do 690 756, South Korea
    Brain Res 1040:178-86. 2005
    NADPH oxidase is multi-component enzyme, which comprises the cytosolic proteins p40Phox, p47Phox, and p67Phox and the two membrane proteins, gp91Phox and p22Phox, and which is well characterized in phagocytic cells...
  6. ncbi Ncf1 (p47phox) polymorphism determines oxidative burst and the severity of arthritis in rats and mice
    Malin Hultqvist
    Section for Medical Inflammation Research, Lund University, Lund, Sweden
    Cell Immunol 233:97-101. 2005
    ..By using an alternative approach, i.e., linkage analysis using relevant animal models we succeeded in finding the Ncf1 gene residing in the Pia4 quantitative trait locus to be responsible for the severity of pristane induced arthritis ..
  7. pmc Exercise Training Attenuates Upregulation of p47(phox) and p67(phox) in Hearts of Diabetic Rats
    Neeru M Sharma
    Department of Cellular and Integrative Physiology, University of Nebraska Medical Center, Omaha, NE 68198, USA
    Oxid Med Cell Longev 2016:5868913. 2016
    ....
  8. doi Neuroprotective effects of angiotensin II type 1 receptor (AT1-R) blocker via modulating AT1-R signaling and decreased extracellular glutamate levels
    Tomoyoshi Fujita
    Department of Ophthalmology, Kagawa University, Kagawa, Japan
    Invest Ophthalmol Vis Sci 53:4099-110. 2012
    ..To investigate the mechanism of the neuroprotective effects of the angiotensin II type 1 receptor (AT1-R) blocker against retinal ischemia-reperfusion injury in the rat...
  9. ncbi Advanced intercross line mapping of Eae5 reveals Ncf-1 and CLDN4 as candidate genes for experimental autoimmune encephalomyelitis
    Kristina Becanovic
    Department of Clinical Neuroscience, Neuroimmunology Unit, Karolinska Institutet, SE 171 76 Stockholm, Sweden
    J Immunol 176:6055-64. 2006
    ..In conclusion, our data strongly suggests Ncf-1 to be a gene shared between two organ-specific inflammatory diseases with a possible contribution by CLDN4 in encephalomyelitis...
  10. pmc Cyclophilin A is required for angiotensin II-induced p47phox translocation to caveolae in vascular smooth muscle cells
    Nwe Nwe Soe
    Department of Medicine, Aab Cardiovascular Research Institute, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA
    Arterioscler Thromb Vasc Biol 33:2147-53. 2013
    ..We hypothesized that CyPA regulates AngII-induced ROS generation by promoting translocation of NADPH oxidase cytosolic subunit p47phox to caveolae of the plasma membrane.
  11. pmc The effect of orexin-A on cardiac dysfunction mediated by NADPH oxidase-derived superoxide anion in ventrolateral medulla
    Jun Chen
    Department of Physiology and Pathophysiology, Shanghai Medical College of Fudan University, Shanghai, China
    PLoS ONE 8:e69840. 2013
    ..double immunofluorescent staining indicated that OX1R positive cells and NAD(P)H oxidative subunit gp91phox or p47phox-immunoreactive (IR) cells were co-localized in RVLM...
  12. doi Oregonin from the Bark of Alnus japonica restrained ischemia-reperfusion-induced mesentery oxidative stress by inhibiting NADPH oxidase activation
    Nguyen Huu Tung
    Faculty of Pharmaceutical Sciences, Nagasaki International University, Nagasaki, Japan
    Microcirculation 21:688-95. 2014
    ..This study aimed to investigate potential effects of ORG on I/R-induced ROS production in rat mesenteric microvasculature and underlying mechanisms...
  13. doi Elevated dopamine induces minimal hepatic encephalopathy by activation of astrocytic NADPH oxidase and astrocytic protein tyrosine nitration
    Saidan Ding
    Zhejiang Provincial Key Laboratory of Aging and Neurological Disease Research, Department of Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China
    Int J Biochem Cell Biol 55:252-63. 2014
    ..It has been shown that low-grade cerebral oedema and oxidative stress play important roles in the pathogenesis of MHE. In the current study, DA-triggered oxidative injury in cerebral cortex was studied...
  14. doi Melatonin nephroprotective action in Zucker diabetic fatty rats involves its inhibitory effect on NADPH oxidase
    Katarzyna Winiarska
    Department of Metabolic Regulation, Institute of Biochemistry, Faculty of Biology, University of Warsaw, Warsaw, Poland
    J Pineal Res 60:109-17. 2016
    ....
  15. pmc A time course of NADPH-oxidase up-regulation and endothelial nitric oxide synthase activation in the hippocampus following neurotrauma
    Mubeen A Ansari
    Sanders Brown Center on Aging, University of Kentucky, Lexington, KY 40536 0230, USA Electronic address
    Free Radic Biol Med 77:21-9. 2014
    ..The initial 12 h post-TBI are very important as a possible window of opportunity to interrupt SIC. It may be important to selectively target the translocation of cytosolic subunits for the modulation of NOX function...
  16. doi NADPH oxidase-derived production of reactive oxygen species is involved in learning and memory impairments in 16-month-old female rats
    Hongwei Kan
    Department of Pharmacology, Key Laboratory of Anti inflammatory and Immunopharmacology, Ministry of Education, Anhui Medical University, Hefei, Anhui 230032, P R China
    Mol Med Rep 12:4546-53. 2015
    ..of superoxide dismutase (SOD), level of malondialdehyde (MDA), production of ROS and expression levels of NOX2, p47phox, Ras‑related C3 botulinum toxin substrate 1 (RAC1) and protein kinase C α (PKCα) were investigated in the ..
  17. pmc Nox2 and p47(phox) modulate compensatory growth of primary collateral arteries
    Matthew R Distasi
    Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, Indiana
    Am J Physiol Heart Circ Physiol 306:H1435-43. 2014
    ..These results have important implications for the use of antioxidants and the development of therapies for peripheral arterial disease...
  18. doi Testosterone induces vascular smooth muscle cell migration by NADPH oxidase and c-Src-dependent pathways
    Andreia Z Chignalia
    Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, Brazil
    Hypertension 59:1263-71. 2012
    ..Testosterone increased Nox1 and Nox4 mRNA levels and p47phox protein expression, determined by real-time PCR and immunoblotting, respectively...
  19. doi Homocysteine-induced cardiomyocyte apoptosis and plasma membrane flip-flop are independent of S-adenosylhomocysteine: a crucial role for nuclear p47(phox)
    Jessica A Sipkens
    Department of Pathology, VU University Medical Center, De Boelelaan 1117, 1007 MB Amsterdam, The Netherlands
    Mol Cell Biochem 358:229-39. 2011
    ..Incubation with SAH did not have an effect on cell viability, nor on flippase activity, nor on nuclear NOX2-, p47phox expression or nuclear ROS production...
  20. doi NADPH oxidase activation by hyperglycaemia in cardiomyocytes is independent of glucose metabolism but requires SGLT1
    Magali Balteau
    Pôle de Recherche Cardiovasculaire, Institut de Recherche Expérimentale et Clinique, Universite Catholique de Louvain, 10, Avenue Hippocrate, 1200 Brussels, Belgium
    Cardiovasc Res 92:237-46. 2011
    ..In this study, we have dissected the link between glucose transport and metabolism and NADPH oxidase activation under hyperglycaemic conditions...
  21. pmc Nicorandil prevents endothelial dysfunction due to antioxidative effects via normalisation of NADPH oxidase and nitric oxide synthase in streptozotocin diabetic rats
    Ken Ichi Serizawa
    Product Research Department, Chugai Pharmaceutical Co, Ltd, Gotemba, Shizuoka 412 8513 Japan
    Cardiovasc Diabetol 10:105. 2011
    ..We investigated the protective effect of nicorandil on endothelial function in diabetic rats because endothelial dysfunction is a major risk factor for cardiovascular disease in diabetes...
  22. doi Phosphorylation of smooth muscle 22α facilitates angiotensin II-induced ROS production via activation of the PKCδ-P47phox axis through release of PKCδ and actin dynamics and is associated with hypertrophy and hyperplasia of vascular smooth muscle cells in
    Pin Lv
    Department of Biochemistry and Molecular Biology, College of Basic Medicine, Hebei Medical University, No 361, Zhongshan East Rd, Shijiazhuang, 050017, China
    Circ Res 111:697-707. 2012
    ..However, the mechanisms by which SM22α controls ROS production have not been characterized...
  23. pmc Antisense to protein kinase C-alpha and p47phox attenuates the pro-inflammatory effects of human C-reactive protein in macrophages of biobreeding diabetic rats
    Ishwarlal Jialal
    Laboratory for Atherosclerosis and Metabolic Research, Department of Pathology and Laboratory Medicine, University of California at Davis, Sacramento, CA 95817, USA
    Diab Vasc Dis Res 9:315-9. 2012
    ..spontaneously diabetic biobreeding (BB) rats and increased the MO activity of protein kinase C-alpha (PKC-α) and p47phox. In this report, we tested the effects of molecular inhibition of CRP effects on MO activity using antisense ..
  24. pmc NADPH oxidase elevations in pyramidal neurons drive psychosocial stress-induced neuropathology
    S Schiavone
    Department of Pathology and Immunology, University of Geneva, Geneva, Switzerland
    Transl Psychiatry 2:e111. 2012
    ..Finally, at least at early stages, pharmacological targeting of NOX2 activity might reverse behavioral alterations...
  25. pmc Increased phagocyte-like NADPH oxidase and ROS generation in type 2 diabetic ZDF rat and human islets: role of Rac1-JNK1/2 signaling pathway in mitochondrial dysregulation in the diabetic islet
    Ismail Syed
    Department of Pharmaceutical Sciences, Eugene Applebaum College of Pharmacy and Health Sciences, Detroit, Michigan, USA
    Diabetes 60:2843-52. 2011
    ..To determine the subunit expression and functional activation of phagocyte-like NADPH oxidase (Nox), reactive oxygen species (ROS) generation and caspase-3 activation in the Zucker diabetic fatty (ZDF) rat and diabetic human islets...
  26. doi Neutral sphingomyelinase, NADPH oxidase and reactive oxygen species. Role in acute hypoxic pulmonary vasoconstriction
    Giovanna Frazziano
    Department of Pharmacology, School of Medicine, University Complutense of Madrid, Madrid, Spain
    J Cell Physiol 226:2633-40. 2011
    ..Exogenous ceramide increased ROS production in a PKCζ sensitive manner. We propose an integrated signalling pathway for HPV which includes nSMase-PKCζ-NADPH oxidase as a necessary step required for ROS production and vasoconstriction...
  27. doi NOX2, p22phox and p47phox are targeted to the nuclear pore complex in ischemic cardiomyocytes colocalizing with local reactive oxygen species
    Nynke E Hahn
    Department of Pathology, VU University Medical Centre, De Boelelaan 1117, Amsterdam, The Netherlands
    Cell Physiol Biochem 27:471-8. 2011
    ..g. under ischemia or high concentrations of homocysteine, is an important step in the induction of apoptosis in these cells. Here this ischemia-induced nuclear targeting and activation of NOX2 was specified in cardiomyocytes...
  28. ncbi [Effects of ginsenoside Rb1 on TGF-beta1 induced p47phox expression and extracellular matrix accumulation in rat renal tubular epethelial cells]
    Xi sheng Xie
    Department of Nephrology, West China Hospital, Sichuan University, Chengdu 610041, China
    Sichuan Da Xue Xue Bao Yi Xue Ban 40:106-10. 2009
    ..To investigate the effects of Ginsenoside Rb1 (G-Rb1) on the oxidative damage and extracellular matrix accumulation in rat renal tubular epethelial cells induced by transforming growth factor-beta1 (TGF-beta1)...
  29. pmc Subcellular localization of nicotinamide adenine dinucleotide phosphate oxidase subunits in neurons and astroglia of the rat medial nucleus tractus solitarius: relationship with tyrosine hydroxylase immunoreactive neurons
    M J Glass
    Department of Neurology and Neuroscience, Weill Medical College of Cornell University, New York, NY 10021, USA
    Neuroscience 143:547-64. 2006
    ..Moreover, NADPH oxidase-derived superoxide in neurons and glia may directly or indirectly modulate catecholaminergic neuron activity in the mNTS...
  30. pmc In vitro molecular reconstitution of the respiratory burst in B lymphoblasts from p47-phox-deficient chronic granulomatous disease
    B D Volpp
    Department of Medicine, College of Medicine, University of Iowa, Iowa City
    J Clin Invest 91:201-7. 1993
    ..Thus, B lymphoblasts provide an excellent model system for studies of the NADPH oxidase, for expression of functional recombinant forms of oxidase components, and for initial experimental approaches to genetic reconstitution in CGD...
  31. ncbi Identification of four new quantitative trait loci regulating arthritis severity and one new quantitative trait locus regulating autoantibody production in rats with collagen-induced arthritis
    M M Griffiths
    Department of Veterans Affairs Medical Center, and University of Utah, Salt Lake City, USA
    Arthritis Rheum 43:1278-89. 2000
    ..Collagen-induced arthritis (CIA) is a polygenic model of experimentally induced autoimmunity and chronic joint inflammation. This study maps genetic loci that regulate CIA susceptibility in DA/Bkl (DA) and BN/SsNHsd (BN) rats...
  32. ncbi Glutamine plays a role in superoxide production and the expression of p47phox, p22phox and gp91phox in rat neutrophils
    Tania Cristina Pithon-Curi
    Camilo Castelo Branco University and Methodist University of Piracicaba FACEF, Rua Carolina Fonseca 584, 08230 030 São Paulo, Brazil
    Clin Sci (Lond) 103:403-8. 2002
    ..We postulate that glutamine leads to O(2)(-) production in neutrophils, probably via the generation of ATP and regulation of the expression of components of NADPH oxidase...
  33. ncbi Activation of protein kinase C and nicotinamide adenine dinucleotide phosphate oxidase in leukocytes of spontaneously hypertensive rats
    Kensaku Maeda
    Department of Biochemistry and Molecular Pathology, Osaka City University Medical School, Osaka, Japan
    Hypertens Res 26:999-1006. 2003
    ..Furthermore, expression of p47phox of nicotinamide adenine dinucleotide phosphate oxidase, but not of p67phox, in PMN from SHR was higher than that ..
  34. ncbi Identification of two novel female-specific non-major histocompatibility complex loci regulating collagen-induced arthritis severity and chronicity, and evidence of epistasis
    Hsiang Chi Meng
    North Shore Long Island Jewish Research Institute, Manhasset, New York 11030, USA
    Arthritis Rheum 50:2695-705. 2004
    ....
  35. pmc Leukotrienes enhance the bactericidal activity of alveolar macrophages against Klebsiella pneumoniae through the activation of NADPH oxidase
    Carlos H C Serezani
    Division of Infectious Diseases, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109 0642, USA
    Blood 106:1067-75. 2005
    ..Both classes of LTs elicited translocation of p47phox to the cell membrane, and LTB4 induced phosphorylation of p47phox in a manner dependent on protein kinase C-delta ..
  36. ncbi Cloning of rat p47phox and comparison with human p47phox
    Michiharu Tanabe
    Department of Medical Biochemistry and Biophysics, Division of Physiological Chemistry II, Karolinska Institutet, S 171 77, Stockholm, Sweden
    DNA Seq 16:65-8. 2005
    A cDNA encoding rat p47phox was cloned from rat spleen cDNA library, utilizing rapid amplification of cDNA ends...
  37. ncbi NADPH oxidase and apoptosis in cerulein-stimulated pancreatic acinar AR42J cells
    Ji Hoon Yu
    Department of Pharmacology and Institute of Gastroenterology, Brain Korea 21 Project for Medical Science, Yonsei University College of Medicine, Seoul 120 752, Korea
    Free Radic Biol Med 39:590-602. 2005
    ..These results indicate that NADPH oxidase may mediate ROS-induced apoptosis in pancreatic acinar cells in a Ca(2+)-dependent manner...
  38. ncbi Bile salt-induced apoptosis involves NADPH oxidase isoform activation
    Roland Reinehr
    Clinic for Gastroenterology, Hepatology and Infectiology, Heinrich Heine University Dusseldorf, Dusseldorf, Germany
    Gastroenterology 129:2009-31. 2005
    ..Hydrophobic bile salts trigger a rapid oxidative stress response as an upstream event of CD95 activation and hepatocyte apoptosis...
  39. pmc Hemizygosity at the NCF1 gene in patients with Williams-Beuren syndrome decreases their risk of hypertension
    Miguel del Campo
    Unitat de Genètica, Department de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra, Dr Aiguader 80, 08003 Barcelona, Spain
    Am J Hum Genet 78:533-42. 2006
    ..Deletion breakpoints were precisely defined and were found to result in variability at two genes, NCF1 and GTF2IRD2...
  40. ncbi Myotube depolarization generates reactive oxygen species through NAD(P)H oxidase; ROS-elicited Ca2+ stimulates ERK, CREB, early genes
    Alejandra Espinosa
    Escuela de Tecnología Médica, Facultad de Medicina, Universidad de Chile, Santiago, Chile
    J Cell Physiol 209:379-88. 2006
    ..Myotubes contained both the p47phox and gp91phox phagocytic NAD(P)H oxidase subunits, as revealed by immunodetection...
  41. pmc Glycated albumin activates NADPH oxidase in rat mesangial cells through up-regulation of p47phox
    Yanzhang Li
    Graduate Center for Nutritional Sciences, University of Kentucky, 900 S Limestone Street, Lexington, KY 40536, USA
    Biochem Biophys Res Commun 397:5-11. 2010
    ..Moreover, glycated albumin treatment stimulated the expression and phosphorylation of p47phox, one of the cytosolic regulatory subunits of the NADPH oxidase...
  42. ncbi Hydrophobic bile salts induce hepatocyte shrinkage via NADPH oxidase activation
    Stephan Becker
    Clinic for Gastroenterology, Hepatology and Infectiology Heinrich Heine University Düsseldorf
    Cell Physiol Biochem 19:89-98. 2007
    ..In addition, cell shrinkage induced by proapoptotic bile salts may augment apoptosis by increasing protein breakdown and induction of cholestasis...
  43. pmc Changes in the subcellular distribution of NADPH oxidase subunit p47phox in dendrites of rat dorsomedial nucleus tractus solitarius neurons in response to chronic administration of hypertensive agents
    Michael J Glass
    Department of Neurology and Neuroscience, Weill Medical College of Cornell University, 411 E 69th St, KB410, New York, NY 10021, USA
    Exp Neurol 205:383-95. 2007
    ....
  44. pmc Arthritis suppression by NADPH activation operates through an interferon-beta pathway
    Peter Olofsson
    Biovitrum AB, Arvid Wallgrens Backe 20, Goteborg, Sweden
    BMC Biol 5:19. 2007
    ..the activating component of the nicotinamide adenine dinucleotide phosphate (NADPH) oxidase complex, neutrophil cytosolic factor 1 (NCF1), has previously been identified as a regulator of arthritis severity in mice and rats...
  45. ncbi Differential regulation of NADPH oxidase in sympathetic and sensory Ganglia in deoxycorticosterone acetate salt hypertension
    Xian Cao
    Department of Physiology, Michigan State University, East Lansing, MI 48824, USA
    Hypertension 50:663-71. 2007
    ..This differential regulation may contribute to unbalanced vasomotor control and enhanced vasoconstriction in the splanchnic circulation...
  46. ncbi Amplification of CD95 activation by caspase 8-induced endosomal acidification in rat hepatocytes
    Roland Reinehr
    Clinic for Gastroenterology, Hepatology, and Infectiology, Heinrich Heine University Dusseldorf, D 40225 Dusseldorf, Germany
    J Biol Chem 283:2211-22. 2008
    ..This autoamplification of CD95-activation is required for apoptosis induction...
  47. doi The role of reactive oxygen species in immunopathogenesis of rheumatoid arthritis
    Abbas Mirshafiey
    Department of Immunology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
    Iran J Allergy Asthma Immunol 7:195-202. 2008
    ..The prevailing hypothesis that ROS promote inflammation was recently challenged when polymorphisms in Neutrophil cytosolic factor 1(Ncf1), that decrease oxidative burst, were shown to increase disease severity in mouse and rat ..
  48. doi Detection of arthritis-susceptibility loci, including Ncf1, and variable effects of the major histocompatibility complex region depending on genetic background in rats
    Carola Rintisch
    Lund University, Lund, and Karolinska Institute, Stockholm, Sweden
    Arthritis Rheum 60:419-27. 2009
    ....
  49. pmc Genes for two autosomal recessive forms of chronic granulomatous disease assigned to 1q25 (NCF2) and 7q11.23 (NCF1)
    U Francke
    Department of Genetics and Pediatrics, Stanford University Medical Center, CA 94305 5428
    Am J Hum Genet 47:483-92. 1990
    ..recessive forms of CGD result from defects in cytosolic components of the phagocyte NADPH oxidase system, p47phox (NCF1) and p67phox (NCF2)...
  50. doi Advanced intercross line mapping suggests that ncf1 (ean6) regulates severity in an animal model of guillain-barre syndrome
    Alexander Huberle
    Hertie Institute for Clinical Brain Research, University of Tubingen, Germany
    J Immunol 182:4432-8. 2009
    ..3 Mb on RNO12, harboring the neutrophil cytosolic factor 1 (Ncf1) among other genes...
  51. pmc Modulation of chronic hypoxia-induced chemoreceptor hypersensitivity by NADPH oxidase subunits in rat carotid body
    L He
    Department of Physiology, University of Utah School of Medicine, 420 Chipeta Way, Suite 1700, Salt Lake City, UT 84108 6500, USA
    J Appl Physiol (1985) 108:1304-10. 2010
    ..5-fold) and NOX4 (approximately 3.8-fold) and also increased presence of the regulatory subunit p47phox (approximately 4.2-fold)...

Research Grants2

  1. High Dose Alpha Tocopherol and Carotid Atherosclerosis
    Ishwarlal Jialal; Fiscal Year: 2004
    ..This study has the additional novelty of correlating biomarkers of oxidative stress and inflammation with a cardiovascular endpoint and will establish whether high dose AT decreases atherosclerosis progression. ..
  2. CRP, Diabetes, Atherothrombosis
    Ishwarlal Jialal; Fiscal Year: 2010
    ..CRP augments oxidative stress and inflammation in the diabetic milieu will eventually lead to therapies targeted at reducing inflammation and oxidative stress in diabetes and resulting in a decrease in vasculopathies ..