Nat2

Summary

Gene Symbol: Nat2
Description: N-acetyltransferase 2
Alias: Nat2a, arylamine N-acetyltransferase 2, AT-2, N-Acetyltransferase-2 (arylamine N-acetyltransferase), N-acetyltransferase 2 (arylamine N-acetyltransferase), N-acetyltransferase type 2, NAT-2, arylamide acetylase 2
Species: rat

Top Publications

  1. pmc Haplotype of N-acetyltransferase 1 and 2 and risk of pancreatic cancer
    Li Jiao
    Department of Gastrointestinal Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Cancer Epidemiol Biomarkers Prev 16:2379-86. 2007
  2. ncbi The association between N-acetyltransferase 2 gene polymorphisms and pancreatic cancer
    Lokman Ayaz
    Medical Faculty, Department of Biochemistry, Mersin University, Mersin, Turkey
    Cell Biochem Funct 26:329-33. 2008
  3. ncbi Association between genetic polymorphisms of CYP1A2, arylamine N-acetyltransferase 1 and 2 and susceptibility to cholangiocarcinoma
    A Prawan
    Department of Pharmacologygery, Faculty of Medicine, Liver Fluke and Cholangiocarcinoma Research Center, Khon Kaen University, 40002, Thailand
    Eur J Cancer Prev 14:245-50. 2005
  4. ncbi Polymorphism of arylamine-N-acetyltransferase 2 gene is associated with the risk of atopic dermatitis
    S I Makarova
    Institute of Molecular Biology and Biophysics, Siberian Division of the Russian Academy of Medical Sciences, Russia
    Bull Exp Biol Med 139:662-4. 2005
  5. ncbi N-acetyltransferase 2 phenotype may be associated with susceptibility to age-related cataract
    Lulufer Tamer
    Department of Biochemistry, Mersin University, Medical Faculty, Mersin, Turkey
    Curr Eye Res 30:835-9. 2005
  6. ncbi N-acetyltransferase 2 gene polymorphism and presbycusis
    Murat Unal
    Departments of Otorhinolaryngology, Faculty of Medicine, Mersin University, Mersin, Turkey
    Laryngoscope 115:2238-41. 2005
  7. ncbi Human arylamine N-acetyltransferase 2 polymorphism and susceptibility to allergic contact dermatitis
    Muradiye Nacak
    Department of Pharmacology, Faculty of Medicine, Gaziantep University, Turkey
    Int J Dermatol 45:323-6. 2006
  8. ncbi Polymorphisms at XPD and XRCC1 DNA repair loci and increased risk of oral leukoplakia and cancer among NAT2 slow acetylators
    Mousumi Majumder
    Human Genetics Unit, Biological Sciences Division, Indian Statistical Institute, 203 B T Road, Kolkata 700108, India
    Int J Cancer 120:2148-56. 2007
  9. ncbi Ocular defects associated with a null mutation in the mouse arylamine N-acetyltransferase 2 gene
    Larissa Wakefield
    Department of Pharmacology, University of Oxford, Mansfield Road, Oxford OX1 3QT, UK
    Mamm Genome 18:270-6. 2007
  10. pmc NAT2 6A, a haplotype of the N-acetyltransferase 2 gene, is an important biomarker for risk of anti-tuberculosis drug-induced hepatotoxicity in Japanese patients with tuberculosis
    Norihide Higuchi
    Department of Pharmacotherapeutics, Nagasaki University Graduate School of Biomedical Sciences, 1 14 Bunkyo machi, Nagasaki 852 8521, Japan
    World J Gastroenterol 13:6003-8. 2007

Research Grants

Scientific Experts

  • Lulufer Tamer
  • M Unal
  • D W Hein
  • S Ozawa
  • Toshio Ohtani
  • Azza M Kamel
  • Ranbir C Sobti
  • S Yalin
  • S I Makarova
  • L B Zavodnik
  • E Korpinen
  • Mark A Doll
  • Crisiane Wais Zanrosso
  • Jason M Walraven
  • David F Barker
  • Li Jiao
  • Xiangyang Li
  • Vanessa S Silveira
  • Lisa F Potts
  • Alessandra Faro
  • Maria S Pombo-de-Oliveira
  • Mariana Emerenciano
  • Bruno Alves de Aguiar Gonçalves
  • Mélina Dani
  • Nathaniel Rothman
  • M Chatzimichalis
  • Jin Moo Kim
  • Felicia A Jefferson
  • Yufei Dai
  • Hideo Suzuki
  • Lokman Ayaz
  • Donghui Li
  • James L Abbruzzese
  • Manal M Hassan
  • Melissa L Bondy
  • Ehtesham Arif
  • Mousumi Majumder
  • Larissa Wakefield
  • Norihide Higuchi
  • Muradiye Nacak
  • Xiaoyan Zhang
  • Monica Neri
  • A Prawan
  • Evgeniya V Belogubova
  • Chih Ming Lu
  • M Grundmann
  • O Bandmann
  • T V Viktorova
  • H Brocvielle
  • Junbo Zhu
  • Xuejun Wang
  • Xiaodong Su
  • Xueru Fan
  • Pavel S Pronko
  • Yabin Duan
  • Ming Yuan
  • Xingchen Yao
  • Yongping Li
  • Renata Canalle
  • Ryan J Uitti
  • Rosa Rademakers
  • Carlos Alberto Scrideli
  • Luiz Gonzaga Tone
  • Matthew J Farrer
  • Shesh N Rai
  • Alex C Cambon
  • Owen A Ross
  • Luiz Fernando Lopes
  • Dennis W Dickson
  • Marcela Braga Mansur
  • Zbigniew K Wszolek
  • Irene Litvan
  • Rosane G P Queiroz
  • Federico Canzian
  • Robert N Hoover
  • Thorunn Rafnar
  • Soo Taek Uh
  • Elio Riboli
  • Patrick Sulem
  • Carlotta Sacerdote
  • Amanda Black
  • Robert Grubb
  • Francoise Clavel-Chapelon
  • Ludmila Prokunina-Olsson
  • Salvatore Panico
  • Eric J Jacobs
  • Giuseppe Matullo
  • Josée Michaud
  • Neil Caporaso
  • Shin Hwa Lee

Detail Information

Publications59

  1. pmc Haplotype of N-acetyltransferase 1 and 2 and risk of pancreatic cancer
    Li Jiao
    Department of Gastrointestinal Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Cancer Epidemiol Biomarkers Prev 16:2379-86. 2007
    We examined the association between N-acetyltransferase 1 and 2 (NAT1 and NAT2) haplotype and risk of pancreatic cancer by genotyping eight NAT1 and seven NAT2 single nucleotide polymorphisms in 532 patients and in 581 healthy controls (..
  2. ncbi The association between N-acetyltransferase 2 gene polymorphisms and pancreatic cancer
    Lokman Ayaz
    Medical Faculty, Department of Biochemistry, Mersin University, Mersin, Turkey
    Cell Biochem Funct 26:329-33. 2008
    ..N-acetyltransferase 1 (NAT1) and N-acetyltransferase 2 (NAT2) are expressed primarily in extrahepatic and hepatic tissues, respectively...
  3. ncbi Association between genetic polymorphisms of CYP1A2, arylamine N-acetyltransferase 1 and 2 and susceptibility to cholangiocarcinoma
    A Prawan
    Department of Pharmacologygery, Faculty of Medicine, Liver Fluke and Cholangiocarcinoma Research Center, Khon Kaen University, 40002, Thailand
    Eur J Cancer Prev 14:245-50. 2005
    ..The present study aimed to evaluate the relationship between CYP1A2, NAT1 and NAT2 polymorphisms and cholangiocarcinoma (CCA), the most prevalent cancer in the north-east of Thailand...
  4. ncbi Polymorphism of arylamine-N-acetyltransferase 2 gene is associated with the risk of atopic dermatitis
    S I Makarova
    Institute of Molecular Biology and Biophysics, Siberian Division of the Russian Academy of Medical Sciences, Russia
    Bull Exp Biol Med 139:662-4. 2005
    ..Double heterozygote 481C/T and 590G/A in girls is a factor of resistance to atopic dermatitis, especially in the absence of smoking-related effects...
  5. ncbi N-acetyltransferase 2 phenotype may be associated with susceptibility to age-related cataract
    Lulufer Tamer
    Department of Biochemistry, Mersin University, Medical Faculty, Mersin, Turkey
    Curr Eye Res 30:835-9. 2005
    ..Genotyping of NAT2 polymorphisms were detected by using a LightCycler-NAT2 mutation detection kit in real-time PCR...
  6. ncbi N-acetyltransferase 2 gene polymorphism and presbycusis
    Murat Unal
    Departments of Otorhinolaryngology, Faculty of Medicine, Mersin University, Mersin, Turkey
    Laryngoscope 115:2238-41. 2005
    ..The effect of aging shows a wide interindividual range; we aimed to investigate whether profiles of NAT2 genotypes may be associated with the risk of presbycusis.
  7. ncbi Human arylamine N-acetyltransferase 2 polymorphism and susceptibility to allergic contact dermatitis
    Muradiye Nacak
    Department of Pharmacology, Faculty of Medicine, Gaziantep University, Turkey
    Int J Dermatol 45:323-6. 2006
    N-acetyltransferase 2 (NAT2) polymorphism may be involved in the pathogenesis of allergic contact dermatitis.
  8. ncbi Polymorphisms at XPD and XRCC1 DNA repair loci and increased risk of oral leukoplakia and cancer among NAT2 slow acetylators
    Mousumi Majumder
    Human Genetics Unit, Biological Sciences Division, Indian Statistical Institute, 203 B T Road, Kolkata 700108, India
    Int J Cancer 120:2148-56. 2007
    Polymorphisms at N-acetyl transferase 2 locus (NAT2) lead to slow, intermediate and rapid acetylation properties of the enzyme. Improper acetylation of heterocyclic and aromatic amines, present in tobacco, might cause DNA adduct formation...
  9. ncbi Ocular defects associated with a null mutation in the mouse arylamine N-acetyltransferase 2 gene
    Larissa Wakefield
    Department of Pharmacology, University of Oxford, Mansfield Road, Oxford OX1 3QT, UK
    Mamm Genome 18:270-6. 2007
    The xenobiotic metabolizing enzyme, mouse arylamine N-acetyltransferase type 2 (Nat2), is expressed during embryogenesis from the blastocyst stage and in the developing neural tube and eye...
  10. pmc NAT2 6A, a haplotype of the N-acetyltransferase 2 gene, is an important biomarker for risk of anti-tuberculosis drug-induced hepatotoxicity in Japanese patients with tuberculosis
    Norihide Higuchi
    Department of Pharmacotherapeutics, Nagasaki University Graduate School of Biomedical Sciences, 1 14 Bunkyo machi, Nagasaki 852 8521, Japan
    World J Gastroenterol 13:6003-8. 2007
    To investigate an association between N-acetyltransferase 2 (NAT2)-haplotypes/diplotypes and adverse effects in Japanese pulmonary tuberculosis patients.
  11. ncbi Interaction effect in bladder cancer between N-acetyltransferase 2 genotype and alcohol drinking
    Chih Ming Lu
    Graduate Institute of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
    Urol Int 75:360-4. 2005
    Cigarette smoking, aromatic amines and ionizing radiation are known carcinogens of bladder cancer. NAT2 genotype might play a role in bladder cancer carcinogenesis...
  12. ncbi Effects of genetic polymorphisms of N-Acetyltransferase on trichloroethylene-induced hypersensitivity dermatitis among exposed workers
    Yufei Dai
    National Institute for Occupational Health and Poison Control, Chinese Center for Disease Control and Prevention, Nanwei Road 29, Beijing, 100050, P R China
    Ind Health 47:479-86. 2009
    ..fragment length polymorphism was used to detect the polymorphic sites of NAT1 at nt 1095 and 1088 and the sites of NAT2 at nt 481, 590, and 857...
  13. doi Down-regulation of liver drug-metabolizing enzymes in a murine model of chronic renal failure
    Mélina Dani
    Centre de Recherche de l Hôpital Maisonneuve Rosemont, Faculte de Medecine, Universite de Montreal, Quebec, Canada
    Drug Metab Dispos 38:357-60. 2010
    ..is related to a decrease in liver cytochrome P450 (P450) and phase II enzymes, particularly N-acetyltransferase 2 (NAT2)...
  14. pmc A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci
    Nathaniel Rothman
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA
    Nat Genet 42:978-84. 2010
    ..3, validated previous candidate associations for the GSTM1 deletion (P = 4 × 10⁻¹¹) and a tag SNP for NAT2 acetylation status (P = 4 × 10⁻¹¹), and found interactions with smoking in both regions...
  15. doi Genetic variability in N-acetyltransferase 2 gene determines susceptibility to childhood lymphoid or myeloid leukemia in Brazil
    Crisiane Wais Zanrosso
    Pediatric Hematology Oncology Program, Research Center, Instituto Nacional de Cancer, Rio de Janeiro, Brazil
    Leuk Lymphoma 53:323-7. 2012
    ..Logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals. N-acetyltransferase 2 (NAT2) SNP 341T > C frequency was higher among both leukemia subtypes compared to controls...
  16. doi CYP3A5 and NAT2 gene polymorphisms: role in childhood acute lymphoblastic leukemia risk and treatment outcome
    Vanessa S Silveira
    Department of Pediatrics, School of Medicine of Ribeirao Preto, University of Sao Paulo, Av Bandeirantes, 3900, HCFMRP Bloco G, 1a, Sl 218 Bairro Monte Alegre, CEP 14049 900, Ribeirao Preto, SP, Brazil
    Mol Cell Biochem 364:217-23. 2012
    ..This study aimed to evaluate the impact of the CYP3A5 and NAT2 metabolizing enzyme polymorphisms on the risk of childhood acute lymphoblastic leukemia...
  17. pmc Polymorphic genes of detoxification and mitochondrial enzymes and risk for progressive supranuclear palsy: a case control study
    Lisa F Potts
    Department of Anatomical Sciences and Neurobiology, University of Louisville, KY, USA
    BMC Med Genet 13:16. 2012
    ..functioning, or oxidative stress response, including debrisoquine 4-hydroxylase, paraoxonase 1 and 2, N-acetyltransferase 1 and 2 (NAT2), superoxide dismutase 1 and 2, and PTEN-induced putative kinase are associated with PSP.
  18. doi Effect of exposure to acute and chronic high-altitude hypoxia on the activity and expression of CYP1A2, CYP2D6, CYP2C9, CYP2C19 and NAT2 in rats
    Xiangyang Li
    Department of Pharmacy, Qinghai University Medical College, Xining, China
    Pharmacology 93:76-83. 2014
    ..chronic high-altitude hypoxia (AHH and CHH) on the activity and expression of CYP1A2, CYP2D6, CYP2C9, CYP2C19 and NAT2 in rats...
  19. doi N-Acetyltransferase 2 (NAT2) polymorphism as a risk modifier of susceptibility to pediatric acute lymphoblastic leukemia
    Azza M Kamel
    Clinical Pathology Department, NCI, Cairo University, Fom El Khalig square, Kasr El Aini St, Cairo, 11796, Egypt
    Tumour Biol 36:6341-8. 2015
    N-Acetyltransferases (NAT) have been known to modify the risk to a variety of solid tumors. However, the role of NAT2 polymorphism in risk susceptibility to childhood acute lymphoblastic leukemia (ALL) is still not well known...
  20. ncbi N-acetyltransferase 2 polymorphisms in patients with Behcet's disease
    L Tamer
    Department of Biochemistry, Mersin University, Turkey
    Clin Exp Dermatol 30:56-60. 2005
    ..induce an autoimmune mechanism, the aim of the present study was to investigate whether the genetic polymorphism of NAT2 plays a role in susceptibility to Behcet's disease...
  21. ncbi Polymorphisms of the xenobiotic-metabolizing enzymes CYP1A1 and NAT-2 in systemic sclerosis and lupus erythematosus
    S von Schmiedeberg
    Department of Dermatology, Heinrich Heine University Dusseldorf, Germany
    Adv Exp Med Biol 455:147-52. 1999
    ..Thus, enhanced formation of reactive metabolites could alter self-proteins presented to the immune system thus stimulating autoreactive T cells which induce autoimmunity...
  22. ncbi Polymorphisms of NAT2 in relation to sulphasalazine-induced agranulocytosis
    M Wadelius
    Department of Medical Sciences, Clinical Pharmacology, University Hospital, Uppsala, Sweden
    Pharmacogenetics 10:35-41. 2000
    ..The polymorphic enzyme N-acetyltransferase 2 (NAT2) plays an important role in the metabolism of sulphasalazine...
  23. ncbi Genetic polymorphism of CYP2D6, GSTM1 and NAT2 and susceptibility to haematological neoplasias
    M C Lemos
    Medical Genetics Unit, Faculty of Medicine, University of Coimbra, and Department of Clinical Haematology, University Hospital of Coimbra, 3049 Coimbra Codex, Portugal
    Carcinogenesis 20:1225-9. 1999
    ..polymorphisms of cytochrome P450 2D6 (CYP2D6), glutathione S-transferase M1 (GSTM1) and N-acetyltransferase 2 (NAT2) and an altered risk for haematological neoplasias...
  24. ncbi Association of prostate cancer with rapid N-acetyltransferase 1 (NAT1*10) in combination with slow N-acetyltransferase 2 acetylator genotypes in a pilot case-control study
    David W Hein
    Department of Pharmacology and Toxicology, University of Louisville School of Medicine, Louisville, Kentucky 40292, USA
    Environ Mol Mutagen 40:161-7. 2002
    N-acetyltransferase-1 (NAT1) and N-acetyltransferase-2 (NAT2) are important in the metabolism of aromatic and heterocyclic amine carcinogens that induce prostate tumors in the rat...
  25. ncbi Association of genotypes of carcinogen-activating enzymes, phenol sulfotransferase SULT1A1 (ST1A3) and arylamine N-acetyltransferase NAT2, with urothelial cancer in a Japanese population
    Shogo Ozawa
    Division of Pharmacology, National Institute of Health Sciences, Tokyo, Japan
    Int J Cancer 102:418-21. 2002
    ..and O-acetylation by phenol sulfating sulfotransferase, ST1A3 (SULT1A1), and arylamine N-acetyltransferase, NAT2, respectively...
  26. ncbi Slow acetylator genotypes as a possible risk factor for infectious mononucleosis-like syndrome induced by salazosulfapyridine
    T Ohtani
    Department of Dermatology, Wakayama Medical University, Kimiidera, Wakayama, Japan
    Br J Dermatol 148:1035-9. 2003
    ..SASP is known to be mainly metabolized by N-acetyltransferase 2 (NAT2), and acetylation phenotypes (rapid, intermediate and slow acetylator) correlate with NAT2* genotypes...
  27. ncbi Association of slow acetylator genotype for N-acetyltransferase 2 with familial Parkinson's disease
    O Bandmann
    University Department of Clinical Neurology, Institute of Neurology, London, UK
    Lancet 350:1136-9. 1997
    ..We investigated the frequency of functionally relevant polymorphisms in six detoxification enzymes among patients with PD to elucidate the relation between these polymorphisms and the disease...
  28. ncbi N-acetyltransferase 2 acetylation polymorphism: prevalence of slow acetylators does not differ between atopic dermatitis patients and healthy subjects
    H Brocvielle
    Laboratoire d ingénierie et de biologie cutanées, Faculte de Medecine et de Pharmacie, Besancon, France
    Skin Pharmacol Appl Skin Physiol 16:386-92. 2003
    The genetic polymorphism of human N-acetyltransferase 2 (NAT2) divides the human population into groups with rapid, intermediate and slow acetylator status...
  29. ncbi NAT2 genotyping and efficacy of sulfasalazine in patients with chronic discoid lupus erythematosus
    N Sabbagh
    Laboratoire de Biochimie et Biologie Moléculaire de l Hôpital Calmette, Universitaire de Lille, France
    Pharmacogenetics 7:131-5. 1997
    ..in metabolism of the drug which is extensively acetylated by the polymorphic enzyme N-acetyltransferase 2 (NAT2)...
  30. doi N-acetyltransferase 2 polymorphisms and susceptibility to infant leukemia with maternal exposure to dipyrone during pregnancy
    Crisiane Wais Zanrosso
    Pediatric Hematology Oncology Program, Research Center, Instituto Nacional de Cancer, Rio de Janeiro, Brazil
    Cancer Epidemiol Biomarkers Prev 19:3037-43. 2010
    ..N-Acetyltransferase 2 (NAT2) enzyme acetylates dipyrone, resulting in a detoxified metabolite...
  31. doi Association analysis of N-acetyl transferase-2 polymorphisms with aspirin intolerance among asthmatics
    Jin Moo Kim
    Genome Research Center for Allergy and Respiratory disease, Soonchunhyang University Bucheon Hospital, 1174 Jung dong, Wonmi gu, Bucheon, Gyeonggi do 420 767, Republic of Korea
    Pharmacogenomics 11:951-8. 2010
    ..Cysteinyl leukotrienes are inactivated by acetyl coenzyme A-dependent N-acetyltransferase (NAT). Thus, functional alterations of the NAT gene may contribute to the risk of aspirin-intolerant asthma...
  32. ncbi Glutathione S-transferase and N-acetyltransferase genotypes and asbestos-associated pulmonary disorders
    A Hirvonen
    Department of Industrial Hygiene and Toxicology, Finnish Institute of Occupational Health, Helsinki, Finland
    J Natl Cancer Inst 88:1853-6. 1996
    ..e., both copies lost) of these genes can be detected. Polymorphism of the NAT2 gene results in slow and fast acetylators of potentially toxic substances...
  33. doi GSTT1, GSTM1, GSTM3 and NAT2 polymorphisms in laryngeal squamous cell carcinoma in a Greek population
    M Chatzimichalis
    Department of Otolaryngology Head and Neck Surgery, METAXA Anticancer Hospital, Piraeus, Greece
    J Laryngol Otol 124:318-23. 2010
    ..Accumulating evidence suggests that alterations of detoxification enzymes, such as glutathione S-transferases and N-acetyltransferases, influence the risk of cancers associated with tobacco smoke and alcohol...
  34. ncbi N-acetyltransferase-2 polymorphism, smoking and type 1 diabetic nephropathy
    E Korpinen
    Hospital for Children and Adolescents, University of Helsinki, Finland
    Pharmacogenetics 9:627-33. 1999
    The N-acetyltransferase (NAT2) polymorphism has been suggested to be related to diabetic microvascular complications...
  35. ncbi Recombinant rat and hamster N-acetyltransferases-1 and -2: relative rates of N-acetylation of arylamines and N,O-acyltransfer with arylhydroxamic acids
    R F Jones
    Molecular and Chemical Carcinogenesis Program, Karmanos Cancer Institute, Wayne State University College of Medicine, Detroit, MI 48201, USA
    Carcinogenesis 17:1729-33. 1996
    Genes for the 290 amino acid, 33-34 kDa cytosolic acetyltransferases (NAT1* and NAT2*) from rat and hamster were cloned and expressed in Escherichia coli...
  36. doi Impact of interaction of polymorphic forms of p53 codon 72 and N-acetylation gene (NAT2) on the risk of lung cancer in the North Indian population
    Ranbir C Sobti
    Department of Biotechnology, Panjab University, Chandigarh, India
    DNA Cell Biol 28:443-9. 2009
    ..We studied the influence of NAT2 and codon 72 p53 polymorphisms on 151 patients with lung cancer and an equal number of matched population controls...
  37. ncbi Cloning, sequencing and expression of NAT1 and NAT2 encoding genes from rapid and slow acetylator inbred rats
    M A Doll
    Department of Pharmacology and Toxicology, University of North Dakota School of Medicine, Grand Forks 58202 9037, USA
    Pharmacogenetics 5:247-51. 1995
  38. ncbi Complementary DNAs for two arylamine N-acetyltransferases with identical 5' non-coding regions from rat pineal gland
    T Ebisawa
    Department of Molecular Neurobiology, Tokyo Metropolitan Institute for Neuroscience, Japan
    Eur J Biochem 228:129-37. 1995
    ....
  39. pmc 4-Aminobiphenyl downregulation of NAT2 acetylator genotype-dependent N- and O-acetylation of aromatic and heterocyclic amine carcinogens in primary mammary epithelial cell cultures from rapid and slow acetylator rats
    Felicia A Jefferson
    Department of Pharmacology and Toxicology, University of Louisville School of Medicine, Louisville, Kentucky 40292, USA
    Toxicol Sci 107:293-7. 2009
    ..N-acetyltransferase 1 (NAT1) and N-acetyltransferase 2 (NAT2) enzymes have important roles in their metabolic activation and deactivation...
  40. pmc Quantitative tissue and gene-specific differences and developmental changes in Nat1, Nat2, and Nat3 mRNA expression in the rat
    David F Barker
    Department of Pharmacology and Toxicology, University of Louisville School of Medicine, Louisville, KY 40292, USA
    Drug Metab Dispos 36:2445-51. 2008
    Human N-acetyltransferase 1 (NAT1) and 2 (NAT2) are important phase II enzymes involved in the biotransformation of xenobiotics...
  41. pmc Systemic functional expression of N-acetyltransferase polymorphism in the F344 Nat2 congenic rat
    David W Hein
    Department of Pharmacology and Toxicology, University of Louisville School of Medicine, Louisville, KY 40292, USA
    Drug Metab Dispos 36:2452-9. 2008
    Rat lines congenic for the rat N-acetyltransferase 2 [(RAT)Nat2] gene were constructed and characterized. F344 (homozygous Nat2 rapid) males were mated to Wistar Kyoto (homozygous Nat2 slow) females to produce heterozygous F1...
  42. pmc Interaction of the cytochrome P4501A2, SULT1A1 and NAT gene polymorphisms with smoking and dietary mutagen intake in modification of the risk of pancreatic cancer
    Hideo Suzuki
    Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Carcinogenesis 29:1184-91. 2008
    ..Cytochrome P450 (CYP) 1A2, N-acetyltransferase (NAT) 1, NAT2 and sulfotransferase (SULT) are enzymes involved in the metabolism of these carcinogens...
  43. ncbi 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine induces a higher number of aberrant crypt foci in Fischer 344 (rapid) than in Wistar Kyoto (slow) acetylator inbred rats
    M Purewal
    Department of Gastrointestinal Medical Oncology and Digestive Diseases, The University of Texas M D Anderson Cancer Center, Houston 77030, USA
    Cancer Epidemiol Biomarkers Prev 9:529-32. 2000
    ..N-Acetyltransferase-2 (NAT2) catalyzes the conversion of PhIP and other heterocyclic amines to a DNA-reactive form...
  44. pmc Tissue expression and genomic sequences of rat N-acetyltransferases rNat1, rNat2, rNat3, and Functional characterization of a novel rNat3*2 genetic variant
    Jason M Walraven
    Department of Pharmacology and Toxicology and James Graham Brown Cancer Center, University of Louisville School of Medicine, Louisville, Kentucky 40292, USA
    Toxicol Sci 99:413-21. 2007
    Human arylamine N-acetyltransferases NAT1 and NAT2 are highly polymorphic genes that modify individual susceptibility to cancers caused by exposure to arylamine procarcinogens...
  45. ncbi Acinar distribution of rat liver arylamine N-acetyltransferase: effect of chronic ethanol and endotoxin exposure
    Pavel S Pronko
    Institute of Biochemistry, National Academy of Sciences of Belarus, Grodno
    Pharmacol Toxicol 90:150-4. 2002
    ....
  46. ncbi Association of CYP2E1 and NAT2 gene polymorphisms with chronic obstructive pulmonary disease
    Ehtesham Arif
    Functional Genomics Unit, Institute of Genomics and Integrative Biology, Delhi, India
    Clin Chim Acta 382:37-42. 2007
    ..Detoxification genes are potential candidates in the susceptibility of patients with chronic obstructive pulmonary disease. Polymorphisms in these genes alter the metabolism of xenobiotics such as present in cigarette smoke...
  47. ncbi Relationship between N-acetyl transferase-2 gene polymorphism and risk of bronchial asthma
    Lulufer Tamer
    Department of Biochemistry, Faculty of Medicine, Mersin University, Mersin, Turkey
    Tuberk Toraks 54:137-43. 2006
    ..The aim of the present study was to investigate further whether the genetic polymorphism of the NAT2 plays a role in susceptibility to bronchial asthma disease...
  48. ncbi N-acetyltransferase 2 polymorphism in patients with diabetes mellitus
    Serap Yalin
    Mersin University Pharmacy School, Department of Biochemistry, Mersin, Turkey
    Cell Biochem Funct 25:407-11. 2007
    ..06; 95%CI: 10.55-209.77 for NAT 2*5A, OR = 18.48; 95%CI: 3.83-89.11 for NAT2*6A and OR = 18.22; 95%CI: 6.29-52.76 for NAT2*14A)...
  49. ncbi Nomenclature for N-acetyltransferases
    K P Vatsis
    Department of Pharmacology, Medical School, University of Michigan, Ann Arbor 48109 0632, USA
    Pharmacogenetics 5:1-17. 1995
    ..For designation of genotypes at a single NAT* locus, a slash serves to separate the alleles; in phenotype designations, which are not italicized, alleles are separated by a comma...
  50. ncbi [Analysis of the N-acetyltransferase 2 gene polymorphism in the patients with chronic obstructive pulmonary disease and in populations of the Volga-Ural region]
    T V Viktorova
    Institute of Biochemistry and Genetics, Russian Academy of Sciences, Ufa, 450054 Bashkortostan, Russia
    Genetika 39:855-7. 2003
    Restriction fragment-length polymorphism of the gene coding for N-acetyltransferase 2 (NAT2) was typed in populations of the Volga-Ural region (Bashkirs, Tatars, Chuvashes, Udmurts, and Russians) as well as in patients with chronic ..
  51. pmc 4,4'-methylenedianiline-induced hepatotoxicity is modified by N-acetyltransferase 2 (NAT2) acetylator polymorphism in the rat
    Xiaoyan Zhang
    Department of Pharmacology and Toxicology, University of Louisville School of Medicine, Louisville, KY 40292, USA
    J Pharmacol Exp Ther 316:289-94. 2006
    ..MDA undergoes N-acetylation catalyzed by N-acetyltransferase 1 (NAT1) and 2 (NAT2) in the liver...
  52. ncbi Genetic polymorphism of N-acetyltransferase 2 in the susceptibility to laryngeal squamous cell carcinoma
    Murat Unal
    Mersin Universitesi Tip Fakultesi Hastanesi, KBB Anabilim Dali, Zeytinlibahce Cad, 33079, Mersin, Turkey
    Head Neck 27:1056-60. 2005
    The purpose of this study was to investigate whether polymorphism of N-acetyltransferase 2 (NAT2) genotypes are associated with the risk of laryngeal squamous cell carcinoma (SCC).
  53. ncbi Pleural malignant mesothelioma, genetic susceptibility and asbestos exposure
    Monica Neri
    Unit of Epidemiology and Biostatistics, National Cancer Research Institute, Largo Rosanna Benzi 10, 16132 Genoa, Italy
    Mutat Res 592:36-44. 2005
    ..The role of mEH, GSTM1, GSTT1, NAT2, and CYP1A1 genotypes in modulating susceptibility to MM was examined in a case-control study of 80 subjects with a ..
  54. ncbi Slow N-acetyltransferase 2 status leads to enhanced intrastriatal dopamine depletion in 6-hydroxydopamine-lesioned rats
    M Grundmann
    Department of Neurology, Philipps University, Marburg, Germany
    Exp Neurol 187:199-202. 2004
    We previously reported an association between the N-acetyltransferase 2 (NAT2) slow acetylator status and Parkinson's disease (PD)...
  55. ncbi 'Comparison of extremes' approach provides evidence against the modifying role of NAT2 polymorphism in lung cancer susceptibility
    Evgeniya V Belogubova
    Group of Molecular Diagnostics, N N Petrov Institute of Oncology, Pesochny 2, St Petersburg 197758, Russian Federation
    Cancer Lett 221:177-83. 2005
    b>NAT2 (arylamine N-acetyltransferase 2) polymorphism, being a key determinant of individual variations in acetylation capacity, is suspected to modify the risk of carcinogen-related malignancies...

Research Grants1

  1. PHARMACOGENETICS OF DRUG AND CARCINOGEN METABOLISM
    David Hein; Fiscal Year: 2009
    ..breast cancer in those individuals with rapid and/or slow acetylator N-acetyltransferase- 1 (NAT1) and - 2 (NAT2) acetylator genotypes...