Muc5ac

Summary

Gene Symbol: Muc5ac
Description: mucin 5AC, oligomeric mucus/gel-forming
Alias: LOW QUALITY PROTEIN: mucin-5AC, mucin 5, subtypes A and C, mucin 5, subtypes A and C, tracheobronchial/gastric
Species: rat

Top Publications

  1. ncbi Prognostic value of serum MUC5AC mucin in patients with cholangiocarcinoma
    Chanchai Boonla
    Department of Biochemistry, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand
    Cancer 98:1438-43. 2003
  2. pmc Trefoil factor family 1, MUC5AC and human leucocyte antigen-DR expression by conjunctival cells in patients with glaucoma treated with chronic drugs: could these markers predict the success of glaucoma surgery?
    M Souchier
    Service d Ophtalmologie, Hopital General, 21000 Dijon, France
    Br J Ophthalmol 90:1366-9. 2006
  3. doi MUC19 expression in human ocular surface and lacrimal gland and its alteration in Sjögren syndrome patients
    D F Yu
    State Key Laboratory of Ophthalmology of Sun Yat sen University, Zhongshan Ophthalmic Center, Ocular Surface Center of Sun Yat Sen University, Guangzhou, China
    Exp Eye Res 86:403-11. 2008
  4. pmc MUC5AC expression in human middle ear epithelium of patients with otitis media
    Joseph E Kerschner
    Division of Pediatric Otolaryngology, Children s Hospital of Wisconsin, 9000 W Wisconsin Ave, Milwaukee, WI 53226, USA
    Arch Otolaryngol Head Neck Surg 136:819-24. 2010
  5. pmc A mouse dry eye model induced by topical administration of benzalkonium chloride
    Zhirong Lin
    State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat Sen University, Guangzhou, People s Republic of China
    Mol Vis 17:257-64. 2011
  6. ncbi Mapping of two new epitopes on the apomucin encoded by MUC5AC gene: expression in normal GI tract and colon tumors
    Séverine Nollet
    INSERM U 482, Hopital Saint Antoine, Paris, France
    Int J Cancer 99:336-43. 2002
  7. ncbi Altered mucin gene expression in stone-containing intrahepatic bile ducts and cholangiocarcinomas
    K T Lee
    Department of Surgery, Faculty of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
    Dig Dis Sci 46:2166-72. 2001
  8. doi Chronic Aspergillus fumigatus exposure upregulates the expression of mucin 5AC in the airways of asthmatic rats
    Fu Sheng Gao
    Department of Respiratory Medicine, The Affiliated Hospital of Weifang Medical College, Weifang, China
    Exp Lung Res 38:256-65. 2012
  9. ncbi Increased expression of human calcium-activated chloride channel 1 is correlated with mucus overproduction in the airways of Chinese patients with chronic obstructive pulmonary disease
    Ke Wang
    Division of Pulmonary Diseases, State Key Laboratory of Biotherapy of China, and Department of Respiratory Medicine, West China Hospital of Sichuan University, Chengdu 610041, China
    Chin Med J (Engl) 120:1051-7. 2007
  10. pmc Gamma-tocopherol attenuates ozone-induced exacerbation of allergic rhinosinusitis in rats
    James G Wagner
    Department of Pathobiology and Diagnostic Investigation, Michigan State University, East Lansing, MI 48824, USA
    Toxicol Pathol 37:481-91. 2009

Research Grants

Scientific Experts

  • Nia Kania
  • Joseph Edward Kerschner
  • James G Wagner
  • Weiwei Wang
  • A Gomi
  • S Yonezawa
  • Markus O Henke
  • Murat Dogru
  • Gaetano Caramori
  • Fu Sheng Gao
  • Ke Wang
  • Chanchai Boonla
  • Fu Qiang Wen
  • Dan Xu
  • J Cortijo
  • Dong Hyun Kim
  • Jianan Zhang
  • Jacques Bara
  • M Mata
  • Daigo Tsubokawa
  • Yan Yan Gao
  • Yong quan Liu
  • Mei Juan Liu
  • Anne M Floyd
  • Cong Tian
  • Qing Yin Zheng
  • Sheng li Li
  • Zhirong Lin
  • Y F Tan
  • Dae Yong Kim
  • Sumaira Z Hasnain
  • Marylène Fortin
  • Wenqing Cao
  • Bing Yuan
  • C A Hewson
  • Wei Liu
  • Sabrina Viau
  • Wen Li Wu
  • Umadevi Sajjan
  • Lei Chen
  • Tingting Yue
  • Y Wang
  • W R Matull
  • D F Yu
  • Zhi Pin Deng
  • Yi Wang
  • Ljubinka Jankovic Velickovic
  • Nicole Maurin
  • Yu Ling Feng
  • Ruijin Li
  • Jie Yang
  • Xue Mei Ou
  • Ahmed E Hegab
  • Sandra Zoghbi
  • M Souchier
  • S Aishima
  • E J Morcillo
  • Fei Han
  • Su Youn Nam
  • Wenju Lu
  • Marie Elisabeth Forgue-Lafitte
  • Hiroyuki Yamasaki
  • Hee Jin Chang
  • Koichi Hashimoto
  • Sopit Wongkham
  • Haili Lü
  • Je Hyeong Kim
  • Xiu Jun Song
  • Shahriar Shahzeidi
  • Jeroen H B Van De Bovenkamp
  • Séverine Nollet
  • Darryl Choo
  • Haili Li
  • Xiaoming Yan
  • Sang Won Yeo
  • Hiroko Maruyama
  • Cynthia F Bartels
  • Peter C Scacheri
  • Yin Chen
  • Fumi Yatabe
  • Deborah Schelling
  • Xu Zhou
  • Takafumi Ichikawa
  • Christopher Evans
  • Olivia J Rompala
  • K T Lee
  • Fengchan Han
  • Heping Yu
  • Mingwu Wang
  • Bin Yang

Detail Information

Publications70

  1. ncbi Prognostic value of serum MUC5AC mucin in patients with cholangiocarcinoma
    Chanchai Boonla
    Department of Biochemistry, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand
    Cancer 98:1438-43. 2003
    The authors recently showed that MUC5AC mucin, which is expressed aberrantly in tumor tissue, is present in significant concentrations in serum from patients with cholangiocarcinoma...
  2. pmc Trefoil factor family 1, MUC5AC and human leucocyte antigen-DR expression by conjunctival cells in patients with glaucoma treated with chronic drugs: could these markers predict the success of glaucoma surgery?
    M Souchier
    Service d Ophtalmologie, Hopital General, 21000 Dijon, France
    Br J Ophthalmol 90:1366-9. 2006
    To evaluate conjunctival expression of trefoil factor family (TFF)1, MUC5AC and human leucocyte antigen (HLA)-DR in patients with glaucoma treated with topical drugs, and to determine whether these parameters can predict the outcome of ..
  3. doi MUC19 expression in human ocular surface and lacrimal gland and its alteration in Sjögren syndrome patients
    D F Yu
    State Key Laboratory of Ophthalmology of Sun Yat sen University, Zhongshan Ophthalmic Center, Ocular Surface Center of Sun Yat Sen University, Guangzhou, China
    Exp Eye Res 86:403-11. 2008
    ..Real-time PCR and immunohistochemistry were performed to determine the expression of MUC19 and MUC5AC in human cornea, conjunctiva, and lacrimal gland tissues...
  4. pmc MUC5AC expression in human middle ear epithelium of patients with otitis media
    Joseph E Kerschner
    Division of Pediatric Otolaryngology, Children s Hospital of Wisconsin, 9000 W Wisconsin Ave, Milwaukee, WI 53226, USA
    Arch Otolaryngol Head Neck Surg 136:819-24. 2010
    To compare levels of middle ear (ME) MUC5AC expression in patients with otitis media (OM) with patients without OM...
  5. pmc A mouse dry eye model induced by topical administration of benzalkonium chloride
    Zhirong Lin
    State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat Sen University, Guangzhou, People s Republic of China
    Mol Vis 17:257-64. 2011
    ..To develop a dry eye model of mouse induced by topical administration of benzalkonium chloride (BAC) and investigate the possible mechanisms...
  6. ncbi Mapping of two new epitopes on the apomucin encoded by MUC5AC gene: expression in normal GI tract and colon tumors
    Séverine Nollet
    INSERM U 482, Hopital Saint Antoine, Paris, France
    Int J Cancer 99:336-43. 2002
    ..These MAbs immunoreacted against a human recombinant protein encoded by the 3' region of the MUC5AC gene...
  7. ncbi Altered mucin gene expression in stone-containing intrahepatic bile ducts and cholangiocarcinomas
    K T Lee
    Department of Surgery, Faculty of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
    Dig Dis Sci 46:2166-72. 2001
    ..bile ducts, cholangiocarcinomas, and normal controls to identify the expression of MUC2, MUC3, MUC4, MUC5B, and MUC5AC in nonneoplastic and neoplastic biliary epithelium...
  8. doi Chronic Aspergillus fumigatus exposure upregulates the expression of mucin 5AC in the airways of asthmatic rats
    Fu Sheng Gao
    Department of Respiratory Medicine, The Affiliated Hospital of Weifang Medical College, Weifang, China
    Exp Lung Res 38:256-65. 2012
    ..The effects of chronic A. fumigatus exposure on the expression of airway mucin 5AC (MUC5AC) are unknown.
  9. ncbi Increased expression of human calcium-activated chloride channel 1 is correlated with mucus overproduction in the airways of Chinese patients with chronic obstructive pulmonary disease
    Ke Wang
    Division of Pulmonary Diseases, State Key Laboratory of Biotherapy of China, and Department of Respiratory Medicine, West China Hospital of Sichuan University, Chengdu 610041, China
    Chin Med J (Engl) 120:1051-7. 2007
    ..To investigate the relationship of CaCC(1) and mucus overproduction in the airway of Chinese patients with COPD, the expressions of CaCC(1), MUC5AC and mucus in bronchial tissues were examined.
  10. pmc Gamma-tocopherol attenuates ozone-induced exacerbation of allergic rhinosinusitis in rats
    James G Wagner
    Department of Pathobiology and Diagnostic Investigation, Michigan State University, East Lansing, MI 48824, USA
    Toxicol Pathol 37:481-91. 2009
    ..and analyzed by reverse transcriptase polymerase chain reaction (RT-PCR) for mucin glycoprotein 5AC (MUC5AC) expression levels...
  11. doi Panax ginseng ameliorates airway inflammation in an ovalbumin-sensitized mouse allergic asthma model
    Dae Yong Kim
    Department of Pharmacology, Sungkyunkwan University School of Medicine, 300 Chunchun dong, Jangan ku, Suwon 440 746, Republic of Korea
    J Ethnopharmacol 136:230-5. 2011
    ..Panax ginseng (PG) is a medicinal herb that has been used to treat various immune diseases including asthma and COPD. In this study, we investigated the inhibitory mechanism of PG on asthma parameters in mice...
  12. ncbi [Effects of acrolein exposure on the expression of Muc5ac in the airway of rats]
    Bing Yuan
    Department of Respiration, the First Affiliated Hospital of Yunnan Province, Kunming Medical College, Kunming 650000, China
    Sichuan Da Xue Xue Bao Yi Xue Ban 41:994-7. 2010
    To explore the changes of Muc5ac expression in a rat model of mucus hypersecretion induced by acrolein.
  13. doi Analysis of the correlations of mucins, inflammatory markers, and clinical tests in dry eye
    Jianan Zhang
    Department of Ophthalmology, Peking University First Hospital, Key Laboratory of Vision Loss and Restoration, Ministry of Education, Beijing, China
    Cornea 32:928-32. 2013
    ..To investigate the expression of mucin and inflammatory factors in the conjunctival epithelium of subjects with dry eye and determine a correlation between clinical laboratory tests and subjective symptoms...
  14. ncbi Ocular surface and tear functions after topical cyclosporine treatment in dry eye patients with chronic graft-versus-host disease
    Y Wang
    Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan
    Bone Marrow Transplant 41:293-302. 2008
    ..staining scores, goblet cells density, conjunctival squamous metaplasia grade, inflammatory cell numbers and the MUC5AC expression. Our study suggests that 0...
  15. pmc Mucin deficiency causes functional and structural changes of the ocular surface
    Anne M Floyd
    Department of Pharmacology and Toxicology, University of Arizona, Tucson, Arizona, United States of America
    PLoS ONE 7:e50704. 2012
    b>MUC5AC is the most abundant gel-forming mucin in the ocular system. However, the specific function is unknown...
  16. doi Alterations of the ocular surface epithelial MUC16 and goblet cell MUC5AC in patients with atopic keratoconjunctivitis
    M Dogru
    Department of Ophthalmology, Tokyo Dental College Ichikawa General Hospital, Ichikawa, Japan
    Allergy 63:1324-34. 2008
    ..An increased understanding of the ocular surface at cellular level in the conjunctiva and the cornea may help explain the pathogenesis and the subsequent clinical appearance of atopic ocular allergies, which may be potentially blinding...
  17. pmc Elastase- and LPS-exposed mice display altered responses to rhinovirus infection
    Umadevi Sajjan
    Department of Pediatrics and Communicable Diseases, University of Michigan, 1150 W Medical Center Dr, Rm 3570, MSRBII, Box 5688, Ann Arbor, MI 48109 5688, USA
    Am J Physiol Lung Cell Mol Physiol 297:L931-44. 2009
    ..hyperresponsiveness, increased lung volume, and sustained increases in expression of TNFalpha, IL-5, IL-13, and muc5AC (up to 14 days postinfection)...
  18. pmc Mucin gene deficiency in mice impairs host resistance to an enteric parasitic infection
    Sumaira Z Hasnain
    Faculty of Life Sciences, University of Manchester, Manchester, United Kingdom
    Gastroenterology 138:1763-71. 2010
    ..Nevertheless, the precise role of mucins in host defense in nematode infection is not known. We investigated the role of the mucin (Muc2) in worm expulsion and host immunity in a model of nematode infection...
  19. doi Effect of Bifidobacterium bifidum BF-1 on gastric protection and mucin production in an acute gastric injury rat model
    A Gomi
    Yakult Central Institute for Microbiological Research, Kunitachi, Tokyo, 186 8650, Japan
    J Dairy Sci 96:832-7. 2013
    ..Interestingly, mucin 5ac (muc5ac) gene expression in gastric corpus samples and gastric mucin production in stomach samples from the BF-1 group, ..
  20. pmc The tear fluid mucin 5AC change of primary angle-closure glaucoma patients after short-term medications and phacotrabeculectomy
    Wei Liu
    Tianjin Medical University Eye Center, Tianjin, China
    Mol Vis 16:2342-6. 2010
    This paper proposed to evaluate the tear fluid mucin 5AC (MUC5AC) change in Chinese primary angle-closure glaucoma and cataract patients after short-term medications and phacotrabeculectomy.
  21. pmc Otitis media in a new mouse model for CHARGE syndrome with a deletion in the Chd7 gene
    Cong Tian
    Department of Otolaryngology Head and Neck Surgery, University Hospitals of Cleveland, Case Western Reserve University School of Medicine, Cleveland, Ohio, United States of America
    PLoS ONE 7:e34944. 2012
    ..Gene expression profiling revealed up-regulation of Muc5ac, Muc5b and Tgf-β1 transcripts, the products of which are involved in mucin production and TGF pathway regulation...
  22. doi Effects of normal saline and selenium-enriched hot spring water on experimentally induced rhinosinusitis in rats
    Dong Hyun Kim
    Department of Otolaryngology Head and Neck Surgery, Incheon St Mary s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea
    Int J Pediatr Otorhinolaryngol 77:117-22. 2013
    ..This prospective, randomized, and controlled study examined the effects of normal saline and selenium-enriched hot spring water on experimentally induced rhinosinusitis in rats...
  23. ncbi Differences in the expression of mucins in various forms of cystitis glandularis
    Ljubinka Jankovic Velickovic
    Institute of Pathology, Faculty of Medicine, Nis, Serbia
    Pathol Res Pract 203:653-8. 2007
    ..For this examination, we used a panel of monoclonal-specific antibodies for MUC1, MUC2, MUC5AC, and MUC6...
  24. ncbi The effect of formoterol on airway goblet cell hyperplasia and protein Muc5ac expression in asthmatic mice
    Y F Tan
    Department of Respiratory Medicine, The Second Affiliated Hospital, Sun Yat Sen University, Guangzhou, China
    Eur Rev Med Pharmacol Sci 15:743-50. 2011
    Aim for this study was to investigate the effect of long-acting beta2-adrenoceptor agonist formoterol on airway goblet cell hyperplasia and protein Muc5ac expression in asthmatic mice.
  25. doi Rapid and specific alterations of goblet cell mucin in rat airway and small intestine associated with resistance against Nippostrongylus brasiliensis reinfection
    Daigo Tsubokawa
    Department of Biochemistry, Kitasato University Graduate School of Medical Sciences, 1 15 1 Kitasato, Minami, Sagamihara, Kanagawa 252 0373, Japan
    Exp Parasitol 130:209-17. 2012
    ..the challenge larvae were rejected during the pre-intestinal stage along with marked goblet cell hyperplasia and Muc5AC mucin hyperproduction on the bronchial mucosa, but not as a result of jejunal mucin alteration...
  26. doi Mucin 5 subtype AC expression and upregulation in the nasal mucosa of allergic rhinitis rats
    Weiwei Wang
    Department of Anatomy, Medical College, China Three Gorges University, Yichang City, Hubei Province, China
    Otolaryngol Head Neck Surg 147:1012-9. 2012
    ..hypersecretion in allergic rhinitis (AR), we examined the in vivo effects of an NF-κB inhibitor, ammonium pyrrolidine dithiocarbamate (PDTC), on mucin 5 subtype AC (MUC5AC) expression in the nasal mucosa of ovalbumin-sensitized rats.
  27. ncbi [Toll-like receptor 2 and Toll-like receptor 4 participates in mediation of acute otitis media and mortality in pneumococcal infections in mice]
    Sheng li Li
    Scientific Research Centre, Medical School of Xi an Jiaotong University, Xi an, China
    Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 46:1009-18. 2011
    ..To investigate the roles of Toll-like receptor 2 (TLR2) and Toll-like receptor 4 (TLR4) in host defense against Streptococcus pneumoniae infection in the middle ear...
  28. ncbi [Effects of chronic Aspergillus fumigatus exposure on the expression of mucin 5AC in the airways of asthmatic rats]
    Fu Sheng Gao
    Department of Respiratory Medicine, The Affiliated Hospital of Weifang Medical College, Weifang 261031, China
    Zhonghua Jie He He Hu Xi Za Zhi 35:423-8. 2012
    To explore the effects of chronic Aspergillus fumigatus (Af) exposure on the expression of mucin 5AC (MUC5AC) in the airways of asthmatic rats.
  29. ncbi Relation of epidermal growth factor receptor expression to mucus hypersecretion in diffuse panbronchiolitis
    Je Hyeong Kim
    Pulmonary Division, Department of Internal Medicine, Korea University Guro Hospital, 97 Gurodong Gil, Guro Gu, Seoul, Korea
    Chest 126:888-95. 2004
    ..In this study, we examined the relationship between EGFR expression in the bronchiolar epithelium with neutrophilic inflammation and mucus hypersecretion in the tissues of DPB patients...
  30. ncbi Ocular surface and MUC5AC alterations in atopic patients with corneal shield ulcers
    Murat Dogru
    Department of Ophthalmology, Keio University School of Medicine, Shinanomachi, Tokyo
    Curr Eye Res 30:897-908. 2005
    To describe MUC5AC alterations and the ocular surface disorder in atopic patients with or without corneal ulcers.
  31. ncbi [Expression of MUC5AC in human nasal polyp and inferior turbinate epithelium]
    Haili Lü
    Department of Otolaryngology Head and Neck Surgery, China Japan Union Hospital of Jilin University, Changchun, 130031, China
    Lin Chuang Er Bi Yan Hou Ke Za Zhi 18:649-50. 2004
    To examine the expression of MUC5AC in human nasal polyp and inferior turbinate epithelium, to evaluate the relationship between MUC5AC and the increased mucous secretions in polyps and chronic hypertrophy rhinitis.
  32. ncbi Metaplasia of the duodenum shows a Helicobacter pylori-correlated differentiation into gastric-type protein expression
    Jeroen H B Van De Bovenkamp
    Laboratory of Pediatrics, Erasmus MC Sophia Children s Hospital, Rotterdam, The Netherlands
    Hum Pathol 34:156-65. 2003
    ..Expression was examined immunohistochemically of secretory mucins (MUC2, MUC5AC, MUC5B, and MUC6), trefoil peptides (TFF1, TFF2, and TFF3), and sucrase-isomaltase (SI)...
  33. ncbi Neurturin-deficient mice develop dry eye and keratoconjunctivitis sicca
    Xiu Jun Song
    Cullen Eye Institute, Department of Ophthalmology, Baylor College of Medicine, Houston, TX 77030, USA
    Invest Ophthalmol Vis Sci 44:4223-9. 2003
    ..Neurturin-deficient (NRTN(-/-)) mice have defective parasympathetic innervation of their lacrimal glands. This study was conducted to evaluate tear function and ocular surface phenotype in NRTN(-/-) mice...
  34. ncbi Temporal analysis of goblet cells and mucin gene expression in murine models of allergic asthma
    Shahriar Shahzeidi
    Research Center for Genetic Medicine, Children s National Medical Center Department of Pediatrics, George Washington University, Washington, DC 20010, USA
    Exp Lung Res 29:549-65. 2003
    ..Increased Muc5ac and Muc2 mRNA expression occurred following ovalbumin or IL13, but not saline, exposure...
  35. ncbi Effects of dexamethasone on Muc5ac mucin production by primary airway goblet cells
    Wenju Lu
    Dept of Pharmaceutical Sciences, University of Maryland, Baltimore, MD 21201, USA
    Am J Physiol Lung Cell Mol Physiol 288:L52-60. 2005
    ..In this study, we examined the effect of dexamethasone (DEX) on mRNA expression and synthesis of MUC5AC by A549 human lung adenocarcinoma cells as well as Muc5ac and total high-molecular-weight (HMW) mucins by primary ..
  36. ncbi Altered expression of MUC2, MUC4, and MUC5 mucin genes in pancreas tissues and cancer cell lines
    C Balague
    Departament d Immunologia, Universitat Autonoma de Barcelona, Spain
    Gastroenterology 106:1054-61. 1994
    ..Neoplastic transformation of epithelial cells is commonly associated with altered synthesis and structure of mucin glycoproteins. The aim of the study was to determine if altered mucin gene expression takes place in pancreas cancer...
  37. doi Rhinovirus induces MUC5AC in a human infection model and in vitro via NF-κB and EGFR pathways
    C A Hewson
    Dept of Respiratory Medicine, National Heart and Lung Institute, Imperial College London, Norfolk Place, London, W2 1PG, UK
    Eur Respir J 36:1425-35. 2010
    ..b>MUC5AC is the major mucin produced by bronchial epithelial cells...
  38. doi Spatial and temporal expression of CCR3 and the common beta chain of the IL-3, IL-5 and GM-CSF receptor in the nasal epithelium and lymphoid tissues in a rat model of allergic rhinitis
    Marylène Fortin
    Topigen Pharmaceuticals Inc Pharmaxis Ltd Group, 2901 East Rachel Street, Montreal, Quebec, Canada
    Cytokine 52:194-202. 2010
    ..This study was therefore aimed at characterizing the spatio-temporal expression pattern of βc and CCR3 using a rat model of AR...
  39. ncbi Phenotypic alterations of mucins and cytokeratins during gallbladder carcinogenesis
    Hee Jin Chang
    Department of Pathology, National Cancer Center, Seoul National University College of Medicine, Seoul, Korea
    Pathol Int 54:576-84. 2004
    ..mucin and cytokeratin during gallbladder carcinogenesis, we characterized the expressional profiles of MUC1, MUC2, MUC5AC, MUC6, CK7 and CK20 in 33 normal mucosa, 31 adenomas, 55 dysplasias and 131 carcinomas of the gallbladder...
  40. ncbi Respiratory syncytial virus in allergic lung inflammation increases Muc5ac and gob-5
    Koichi Hashimoto
    Vanderbilt University, School of Medicine, Nashville, Tennessee 37232, USA
    Am J Respir Crit Care Med 170:306-12. 2004
    ..We hypothesized that this increased mucus was associated with mucosal expression of Muc5ac, a mucus gene expression in airways, and gob-5, a member of the Ca(2)(+)-activated chloride channel family...
  41. ncbi Oral N-acetylcysteine reduces bleomycin-induced lung damage and mucin Muc5ac expression in rats
    M Mata
    Dept of Pharmacology, Faculty of Medicine, University of Valencia, Valencia, Spain
    Eur Respir J 22:900-5. 2003
    ..of this antioxidant was examined on bleomycin-induced lung damage, mucus secretory cells hyperplasia and mucin Muc5ac gene expression in rats...
  42. ncbi Expression and localization of MUC1, MUC2, MUC5AC and small intestinal mucin antigen in pancreatic tumors
    Hiroyuki Yamasaki
    Department of Surgery, Division of Frontier Medical Science, Programs for Biomedical Research, Graduate School of Biomedical Sciences, Hiroshima University, Minami Ku, Hiroshima 734 8551, Japan
    Int J Oncol 24:107-13. 2004
    ..We analyzed the expression and localization of MUC1, MUC2, MUC5AC and small intestinal mucin antigen (SIMA) in pancreatic tumors...
  43. ncbi In vivo characterization of the molecular-genetic changes in gastric mucosa during the development of acute gastritis and stress ulceration
    Darryl Choo
    Department of EMS Trauma Surgery, Hartford Hospital, Hartford 06102 5037, USA
    J Trauma 52:720-5; discussion 725-6. 2002
    ..Stress ulceration should be associated with increased heat-shock gene (iHSP70) and an inhibition of the trefoil peptide, spasmolytic polypeptide (SP), and mucin (MUC5AC) gene expressions.
  44. pmc Mucin secretion in the rat tracheal epithelial cells by epidermal growth factor and Pseudomonas aeruginosa extracts
    J S Song
    Department of Internal Medicine, St Mary s Hospital, Catholic University Medical College, 62, Yeoi Do Dong, Young Dung Po Gu, Seoul, Korea, 150 713
    Korean J Intern Med 16:167-72. 2001
    ..To know whether this EGF system regulates mucin secretion in vivo and Pseudomonas also stimulates the mucin secretion by the same pathway, we studied these relationships in the cultured rat tracheal epithelial cells...
  45. ncbi Up-regulation of MUC5AC mRNA expression in endotoxin-induced otitis media
    Y T Kim
    Graduate School of Biotechnology, Korea University, Seoul, South Korea
    Acta Otolaryngol 121:364-70. 2001
    We investigated the expression levels of MUC5AC in endotoxin-induced otitis media with effusion (OME) in the rat using competitive polymerase chain reaction (PCR) and the morphology of middle ear mucosa using transmission electron ..
  46. ncbi Vitamin A deficiency alters the expression of mucin genes by the rat ocular surface epithelium
    M Tei
    Schepens Eye Research Institute, Boston, Massachusetts 02114, USA
    Invest Ophthalmol Vis Sci 41:82-8. 2000
    ..To study effects of depletion of retinoic acid on expression of the mucins ASGP (rMuc4), rMuc5AC, and rMuc1, by the corneal and conjunctival epithelia of the rat...
  47. ncbi Inflammatory and epithelial responses during the development of ozone-induced mucous cell metaplasia in the nasal epithelium of rats
    H Y Cho
    Department of Pharmacology and Toxicology, College of Veterinary Medicine, Michigan State University, East Lansing 48824, USA
    Toxicol Sci 51:135-45. 1999
    ..Ozone-induced MCM may be dependent on these important pre-metaplastic responses (i.e., mucin mRNA upregulation, neutrophilic inflammation, and epithelial proliferation)...
  48. ncbi Gene expression of gastric type mucin (MUC5AC) in pancreatic tumors: its relationship with the biological behavior of the tumor
    S Yonezawa
    Second Department of Pathology, Faculty of Medicine, Kagoshima University, Kagoshima City, Japan
    Pathol Int 49:45-54. 1999
    ..The gastric type secretory mucin, MUC5AC, is strongly expressed in the surface mucous cells of gastric mucosa...
  49. ncbi Cloning of rat Muc5AC mucin gene: comparison of its structure and tissue distribution to that of human and mouse homologues
    T Inatomi
    Schepens Eye Research Institute and Harvard Medical School, Boston, Massachusetts, USA
    Biochem Biophys Res Commun 236:789-97. 1997
    The human mucin gene MUC5AC codes for a large mucin which has tandem repeat units and cysteine rich regions characteristic of several members of this class of glycoproteins...
  50. ncbi Regulation of MUC5 and MUC1 gene expression: correlation with airway mucous differentiation
    K Guzman
    Laboratory of Pulmonary Pathobiology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Am J Physiol 270:L846-53. 1996
    ..These studies demonstrate that expression of MUC1 and MUC5 is coordinately regulated with airway mucous cell differentiation. These cDNAs should provide useful tools to study mucin synthesis during differentiation and disease...
  51. ncbi Gastric mucin phenotype defines tumour progression and prognosis of intrahepatic cholangiocarcinoma: gastric foveolar type is associated with aggressive tumour behaviour
    S Aishima
    Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Histopathology 49:35-44. 2006
    ..To identify the role of mucus core protein (MUC) in intrahepatic cholangiocarcinoma (ICC)...
  52. ncbi [Alteration of cytokines and mucin in lower respiratory tract in allergic rhinitis model in rats]
    Fei Han
    Department of Otorhinolaryngology, Second Hospital of Shanxi Medical University, Taiyuan 030001, China
    Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 40:339-42. 2005
    ..To investigate the relationship between allergic rhinitis (AR) and asthma as well as the mechanisms related with it...
  53. ncbi Progression of tumors arising from large ACF is associated with the MUC5AC expression during rat colon MNNG carcinogenis
    Nicole Maurin
    Laboratoire d Histologie, GHU Pierre et Marie Curie, Hopital St Antoine, Paris, France
    Int J Cancer 120:477-83. 2007
    ..The gastric M1/MUC5AC mucin has also been described as an early marker of colon carcinogenesis in the human and in the rat...
  54. ncbi Intestinal MUC2 and gastric M1/MUC5AC in preneoplastic lesions induced by 1,2-dimethylhydrazine in rat: a sequential analysis
    Sandra Zoghbi
    INSERM, U45, Lyon, IFR62, University Claude Bernard Lyon I, Faculté de Médecine R Laennec, Lyon 69372, France
    Int J Oncol 30:489-97. 2007
    ..Our study was performed to sequentially analyze the expression of the intestinal mucin MUC2 and of the gastric mucin MUC5AC as indicators during progression of preneoplastic biomarkers in rat colon...
  55. ncbi MUC5AC and MUC5B mucins increase in cystic fibrosis airway secretions during pulmonary exacerbation
    Markus O Henke
    Philipps University Marburg, Department of Pulmonary Medicine, Baldingerstrasse 1, 35043 Marburg, Germany
    Am J Respir Crit Care Med 175:816-21. 2007
    ..CF) is believed to be associated with mucus hypersecretion; thus, the principal airway gel-forming mucins, MUC5AC and MUC5B, are also expected to be increased relative to non-CF secretions...
  56. ncbi Niflumic acid and AG-1478 reduce cigarette smoke-induced mucin synthesis: the role of hCLCA1
    Ahmed E Hegab
    Department of Pulmonary Medicine, Institute of Clinical Medicine, University of Tsukuba, 1 1 1 Tennoudai, Tsukuba, Ibaraki 305 8575, Japan
    Chest 131:1149-56. 2007
    ..In this study, we investigated the role of the putative calcium-activated chloride channel 1 (CLCA1) and its blocker, niflumic acid, in cigarette smoke-induced mucin synthesis both in vivo and in vitro...
  57. ncbi Effects of sulfur dioxide on the expressions of MUC5AC and ICAM-1 in airway of asthmatic rats
    Ruijin Li
    Institute of Environmental Medicine and Toxicology, Shanxi University, Taiyuan 030006, China
    Regul Toxicol Pharmacol 48:284-91. 2007
    ..The mRNA and protein levels of MUC5AC and ICAM-1 were analyzed in lungs and tracheas using real-time reverse transcription-polymerase chain reaction (..
  58. ncbi In situ hybridization shows distinct patterns of mucin gene expression in normal, benign, and malignant pancreas tissues
    C Balague
    Departament d Immunologia, Universitat Autonoma de Barcelona, Spain
    Gastroenterology 109:953-64. 1995
    ..The aim of this study was to determine the presence of mucin transcripts at the single cell level in tissue samples from normal pancreas and benign and malignant pancreatic proliferative lesions...
  59. ncbi Increased expression of human calcium-activated chloride channel 1 gene is correlated with mucus overproduction in Chinese asthmatic airway
    Ke Wang
    Division of Pulmonary Diseases, State Key Laboratory of Biotherapy of China, Department of Respiratory Medicine, West China Hospital of Sichuan University, Chengdu, Sichuan 610041, China
    Cell Biol Int 31:1388-95. 2007
    ..channel 1 (CaCC1) and mucus overproduction in Chinese asthmatic airway, the expression of CaCC1, mucin 5AC (MUC5AC) and mucus in bronchial tissues were examined...
  60. ncbi Diagnostic value of mucins (MUC1, MUC2 and MUC5AC) expression profile in endoscopic ultrasound-guided fine-needle aspiration specimens of the pancreas
    Yi Wang
    Department of Gastroenterology, Changhai Hospital, Second Military Medical University, Shanghai, China
    Int J Cancer 121:2716-22. 2007
    ..We immunohistochemically tested mucins expression (MUC1, MUC2 and MUC5AC) in EUS-FNA samples from pancreatic occupying lesions for the diagnostic utility...
  61. ncbi Gastric mucosal protection via enhancement of MUC5AC and MUC6 by geranylgeranylacetone
    Su Youn Nam
    Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Chongno Gu, Seoul, South Korea
    Dig Dis Sci 50:2110-20. 2005
    ..protects tissues from the hazardous gastric environment; however, the role of each gastric MUC type, such as MUC1, MUC5AC, and MUC6, has not been evaluated...
  62. pmc Mucinous nonneoplastic cyst of the pancreas: apomucin phenotype distinguishes this entity from intraductal papillary mucinous neoplasm
    Wenqing Cao
    Department of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    Hum Pathol 41:513-21. 2010
    ..Furthermore, apomucin immunostains of mucinous nonneoplastic cyst showed MUC1 expressed in 27% (4/15) cases, MUC5AC in 67% (10/15 cases), and MUC2 was were negative in all cases, whereas intraductal papillary mucinous neoplasm (n =..
  63. pmc MUC4 and MUC5AC are highly specific tumour-associated mucins in biliary tract cancer
    W R Matull
    The Institute of Hepatology, Division of Medicine, Royal Free and University College London Medical School, London, UK
    Br J Cancer 98:1675-81. 2008
    ..In pancreatic malignancy, MUC4 is a diagnostic and prognostic tumour marker, whereas MUC5AC has been proposed as a sensitive serological marker for BTC...
  64. pmc MUC1 and MUC5AC mucin expression in liver fluke-associated intrahepatic cholangiocarcinoma
    Chanchai Boonla
    Department of Biochemistry, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand
    World J Gastroenterol 11:4939-46. 2005
    To investigate the expressions of MUC1 and MUC5AC in intrahepatic cholangiocarcinoma (ICC)...
  65. doi Toll-like receptor 4 relates to lipopolysaccharide-induced mucus hypersecretion in rat airway
    Lei Chen
    Division of Pulmonary Diseases, State Key Laboratory of Biotherapy of China, and Department of Respiratory Medicine, Sichuan University, Chengdu, Sichuan, China
    Arch Med Res 40:10-7. 2009
    ..To investigate the role of TLR4 in LPS-induced airway mucus hypersecretion (AMH), we used a LPS-induced rat model treated with dexamethasone (DEX)...
  66. pmc Roflumilast, a phosphodiesterase 4 inhibitor, alleviates bleomycin-induced lung injury
    J Cortijo
    Department of Pharmacology, University of Valencia, Spain
    Br J Pharmacol 156:534-44. 2009
    ..The effects of a phosphodiesterase 4 (PDE4) inhibitor, roflumilast, on bleomycin-induced lung injury were explored in 'preventive' and 'therapeutic' protocols and compared with glucocorticoids...
  67. pmc The prevalence and nature of glycan alterations on specific proteins in pancreatic cancer patients revealed using antibody-lectin sandwich arrays
    Tingting Yue
    Van Andel Research Institute, Grand Rapids, Michigan 49503, USA
    Mol Cell Proteomics 8:1697-707. 2009
    ..elevated in the cancer patients (65% of the patients) but showed no glycan alterations, whereas the MUC1 and MUC5AC proteins were less frequently elevated (30 and 35%, respectively) and showed highly prevalent (up to 65%) and ..
  68. doi Efficacy of a 2-month dietary supplementation with polyunsaturated fatty acids in dry eye induced by scopolamine in a rat model
    Sabrina Viau
    INRA, UMR1129 FLAVIC, Eye and Nutrition Research Group, Dijon, 21000, France
    Graefes Arch Clin Exp Ophthalmol 247:1039-50. 2009
    ..This study was conducted to evaluate the efficacy of dietary n-6 and n-3 polyunsaturated fatty acids (PUFAs) in dry eye in a rat model...
  69. ncbi [Effects of glucocorticoid on calcium-activated chloride channel expression in nasal mucosa in allergic rhinitis rats]
    Wen Li Wu
    Department Otorhinolaryngology Head and Neck Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
    Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 44:242-5. 2009
    To investigate the expression of CLCA3 and Muc5ac in nasal mucosa in allergic rhinitis rats and the effects of glucocorticoid on its expression.
  70. doi MUC5AC expression is increased in bronchial submucosal glands of stable COPD patients
    Gaetano Caramori
    Centro di Ricerca su Asma e BPCO, University of Ferrara, Via Savonarola 9, Ferrara 44121, Italy
    Histopathology 55:321-31. 2009
    Mucus expectoration is a common feature of chronic obstructive pulmonary disease (COPD). MUC5AC and MUC5B, the major mucins, are released predominantly from submucosal glands in the central airways...

Research Grants1

  1. Middle Ear Epithelial Response to Cytokine Stimulation
    Joseph Kerschner; Fiscal Year: 2005
    ....