MOR

Summary

Gene Symbol: MOR
Description: opioid receptor, mu 1
Alias: MORA, Oprm, Oprrm1, mu-type opioid receptor, M-OR-1, MOR-1, MUOR1, mu opioid receptor splice variant rMOR-1S, mu opioid receptor splice variant rMOR-1Z, opioid receptor B
Species: rat

Top Publications

  1. ncbi Cloning and expression of an isoform of the rat mu opioid receptor (rMOR1B) which differs in agonist induced desensitization from rMOR1
    A Zimprich
    Department of Physiology, University of Munich, Germany
    FEBS Lett 359:142-6. 1995
  2. ncbi Cloning, characterization, and distribution of a mu-opioid receptor in rat brain
    R L Zastawny
    Department of Pharmacology, University of Toronto, Ontario, Canada
    J Neurochem 62:2099-105. 1994
  3. ncbi Primary structures and expression from cDNAs of rat opioid receptor delta- and mu-subtypes
    K Fukuda
    Department of Anesthesia, Kyoto University Hospital, Japan
    FEBS Lett 327:311-4. 1993
  4. ncbi Rapid modulation of micro-opioid receptor signaling in primary sensory neurons
    Kelly A Berg
    Department of Pharmacology, MS 7764, University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, TX 78229 3900, USA
    J Pharmacol Exp Ther 321:839-47. 2007
  5. doi Activation of the mu opioid receptor involves conformational rearrangements of multiple transmembrane domains
    Wei Xu
    Department of Pharmacology, Center for Substance Abuse Research, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA
    Biochemistry 47:10576-86. 2008
  6. ncbi MOR-1-immunoreactive neurons in the dorsal horn of the rat spinal cord: evidence for nonsynaptic innervation by substance P-containing primary afferents and for selective activation by noxious thermal stimuli
    R C Spike
    Spinal Cord Group, Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow, G12 8QQ, UK
    Eur J Neurosci 15:1306-16. 2002
  7. ncbi Heterodimerization of opioid receptor-like 1 and mu-opioid receptors impairs the potency of micro receptor agonist
    Hung Li Wang
    Department of Physiology, Chang Gung University School of Medicine, Kwei San, Tao Yuan, Taiwan
    J Neurochem 92:1285-94. 2005
  8. pmc Expression of the mu opioid receptor in the human immunodeficiency virus type 1 transgenic rat model
    Sulie L Chang
    Department of Biological Sciences, Seton Hall University, 400 South Orange Avenue, South Orange, NJ 07079, USA
    J Virol 81:8406-11. 2007
  9. ncbi Activation of mu opioid receptors inhibits transient high- and low-threshold Ca2+ currents, but spares a sustained current
    J E Schroeder
    Department of Cell Biology and Physiology, Washington University, St Louis, Missouri 63110
    Neuron 6:13-20. 1991
  10. pmc mu opiate receptor: cDNA cloning and expression
    J B Wang
    Molecular Neurobiology Branch, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD
    Proc Natl Acad Sci U S A 90:10230-4. 1993

Scientific Experts

Detail Information

Publications120 found, 100 shown here

  1. ncbi Cloning and expression of an isoform of the rat mu opioid receptor (rMOR1B) which differs in agonist induced desensitization from rMOR1
    A Zimprich
    Department of Physiology, University of Munich, Germany
    FEBS Lett 359:142-6. 1995
    ..Studies measuring the inhibition of adenylate cyclase in cells that had been pre-exposed to the mu opioid agonist DAMGO indicated that rMOR1B is much more resistant to agonist-induced desensitization than rMOR1...
  2. ncbi Cloning, characterization, and distribution of a mu-opioid receptor in rat brain
    R L Zastawny
    Department of Pharmacology, University of Toronto, Ontario, Canada
    J Neurochem 62:2099-105. 1994
    ....
  3. ncbi Primary structures and expression from cDNAs of rat opioid receptor delta- and mu-subtypes
    K Fukuda
    Department of Anesthesia, Kyoto University Hospital, Japan
    FEBS Lett 327:311-4. 1993
    ..RNA blot hybridization analysis revealed that cerebrum and brainstem contain both ROR-A and ROR-B mRNAs, whereas neither ROR-A nor ROR-B mRNAs can be detected in cerebellum...
  4. ncbi Rapid modulation of micro-opioid receptor signaling in primary sensory neurons
    Kelly A Berg
    Department of Pharmacology, MS 7764, University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, TX 78229 3900, USA
    J Pharmacol Exp Ther 321:839-47. 2007
    ..The results indicate that micro-opioid receptor signaling in primary sensory TG neurons is enhanced by activation of phospholipase C-coupled receptors via a cyclooxygenase-dependent AA metabolite that is downstream of PKC...
  5. doi Activation of the mu opioid receptor involves conformational rearrangements of multiple transmembrane domains
    Wei Xu
    Department of Pharmacology, Center for Substance Abuse Research, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA
    Biochemistry 47:10576-86. 2008
    ....
  6. ncbi MOR-1-immunoreactive neurons in the dorsal horn of the rat spinal cord: evidence for nonsynaptic innervation by substance P-containing primary afferents and for selective activation by noxious thermal stimuli
    R C Spike
    Spinal Cord Group, Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow, G12 8QQ, UK
    Eur J Neurosci 15:1306-16. 2002
    ..In this study we have investigated neurons that express the mu-opioid receptor MOR-1 in rat spinal cord to provide further evidence about their role in nociceptive processing...
  7. ncbi Heterodimerization of opioid receptor-like 1 and mu-opioid receptors impairs the potency of micro receptor agonist
    Hung Li Wang
    Department of Physiology, Chang Gung University School of Medicine, Kwei San, Tao Yuan, Taiwan
    J Neurochem 92:1285-94. 2005
    ..These results provide the evidence that ORL1/muR heterodimerization and the resulting impairment of mu receptor-activated signaling pathways may contribute to ORL1-mediated antiopioid effects in the brain...
  8. pmc Expression of the mu opioid receptor in the human immunodeficiency virus type 1 transgenic rat model
    Sulie L Chang
    Department of Biological Sciences, Seton Hall University, 400 South Orange Avenue, South Orange, NJ 07079, USA
    J Virol 81:8406-11. 2007
    Opioids, via the mu opioid receptor (MOR), can exacerbate bacterial infections and the immunopathogenesis of human immunodeficiency virus type 1 (HIV-1) infection...
  9. ncbi Activation of mu opioid receptors inhibits transient high- and low-threshold Ca2+ currents, but spares a sustained current
    J E Schroeder
    Department of Cell Biology and Physiology, Washington University, St Louis, Missouri 63110
    Neuron 6:13-20. 1991
    ..The kinetic effect on high-threshold current is like that caused by diminished rest potential: the transient component is selectively lost, whereas the sustained component is spared...
  10. pmc mu opiate receptor: cDNA cloning and expression
    J B Wang
    Molecular Neurobiology Branch, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD
    Proc Natl Acad Sci U S A 90:10230-4. 1993
    ....
  11. ncbi Cloning and pharmacological characterization of a rat mu opioid receptor
    R C Thompson
    Mental Health Research Institute, University of Michigan, Ann Arbor 48109 0720
    Neuron 11:903-13. 1993
    ..Based upon these observations, we conclude that pRMuR-12 encodes a mu opioid receptor...
  12. ncbi Molecular cloning and functional expression of a mu-opioid receptor from rat brain
    Y Chen
    Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis 46202
    Mol Pharmacol 44:8-12. 1993
    ..profile of this binding site thus suggests that it is a mu-type opioid receptor, which we designated MOR-1...
  13. ncbi Functional reduction in mu-opioidergic system in the spinal cord under a neuropathic pain-like state following chronic ethanol consumption in the rat
    M Narita
    Department of Toxicology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, 2 4 41 Ebara, Shinagawa ku, Tokyo 142 8501, Japan
    Neuroscience 144:777-82. 2007
    ..35)S]GTPgammaS) binding to membranes of the spinal cord induced by the selective mu-opioid receptor (MOR) agonist, [D-Ala(2),N-MePhe(4),Gly(5)-ol]enkephalin (DAMGO), was significantly decreased under the ethanol-..
  14. pmc Cocaine reward and hyperactivity in the rat: sites of mu opioid receptor modulation
    A R Soderman
    Department of Pharmacology and the Center for Substance Abuse Research, Temple University School of Medicine, Philadelphia, PA 19140, USA
    Neuroscience 154:1506-16. 2008
    ....
  15. pmc High-affinity naloxone binding to filamin a prevents mu opioid receptor-Gs coupling underlying opioid tolerance and dependence
    Hoau Yan Wang
    Department of Physiology and Pharmacology, City University of New York Medical School, New York, New York, USA
    PLoS ONE 3:e1554. 2008
    ..tolerance and dependence by preventing a G protein coupling switch (Gi/o to Gs) by the mu opioid receptor (MOR), although the binding site of such ultra-low-dose opioid antagonists was previously unknown...
  16. pmc Coexpression of delta- and mu-opioid receptors in nociceptive sensory neurons
    Hai bo Wang
    Institute of Neuroscience and State Key Laboratory of Neuroscience, Chinese Academy of Sciences, Shanghai 200031, People s Republic of China
    Proc Natl Acad Sci U S A 107:13117-22. 2010
    ..Importantly, both DOR and MOR agonists reduce depolarization-induced Ca(2+) currents in single small DRG neurons and inhibit afferent C-fiber ..
  17. ncbi Identification of three new alternatively spliced variants of the rat mu opioid receptor gene: dissociation of affinity and efficacy
    David A Pasternak
    Laboratory of Molecular Neuropharmacology, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    J Neurochem 91:881-90. 2004
    ..The mouse and human Oprm genes undergo splicing...
  18. ncbi The mu-opioid receptor down-regulates differently from the delta-opioid receptor: requirement of a high affinity receptor/G protein complex formation
    S Chakrabarti
    Department of Pharmacology, University of Minnesota, Medical School, Minneapolis 55455, USA
    Mol Pharmacol 52:105-13. 1997
    ..Chronic opioid treatment of Neuro2A cells stably expressing either delta-opioid receptor (DOR) or mu-opioid receptor (MOR) resulted in agonist-dependent receptor down-regulation...
  19. ncbi Morphine-6beta-glucuronide-induced hyperphagia: characterization of opioid action by selective antagonists and antisense mapping in rats
    L Leventhal
    Neuropsychology Doctoral Subprogram and Psychology Department, City University of New York, Flushing, New York, New York, USA
    J Pharmacol Exp Ther 287:538-44. 1998
    ..morphine analgesia is decreased by antisense oligodeoxynucleotides (AS ODNs) targeting exons 1 and 4 of the MOR-1 clone, M6G analgesia is reduced by probes targeting exons 2 and 3 of the MOR-1 clone...
  20. ncbi kappa -opioid receptor agonists modulate visceral nociception at a novel, peripheral site of action
    S K Joshi
    Department of Pharmacology, College of Medicine, The University of Iowa, Iowa City 52242, USA
    J Neurosci 20:5874-9. 2000
    ..The present results support the existence of a non-kappa-opioid receptor site of action localized in the colon...
  21. ncbi Chronic arthritis down-regulates peripheral mu-opioid receptor expression with concomitant loss of endomorphin 1 antinociception
    Zongming Li
    University of Calgary, Calgary, Alberta, Canada
    Arthritis Rheum 52:3210-9. 2005
    ..To determine whether peripheral administration of the endogenous mu-opioid peptide endomorphin 1 could reduce knee joint pain, using animal models of acute and chronic arthritis...
  22. ncbi Abnormal modulation of cholinergic neurotransmission by endomorphin 1 and endomorphin 2 in isolated bronchus of type 1 diabetic rats
    Ye Yu
    Department of Biochemistry and Molecular Biology, School of Life Science, Lanzhou University, 222 Tian Shui South Road, Lanzhou 730000, PR China
    Peptides 27:2770-7. 2006
    To assess whether diabetes alters the regulatory effects of mu-opioid receptor (MOR) agonists on the cholinergic bronchoconstriction, we investigated the inhibitory effects of endomorphins (EMs) on the electrical field stimulation (EFS)-..
  23. pmc Ischemic insults promote epigenetic reprogramming of mu opioid receptor expression in hippocampal neurons
    Luigi Formisano
    Dominick P Purpura Department of Neuroscience, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Proc Natl Acad Sci U S A 104:4170-5. 2007
    ..Here we show that REST regulates an additional gene target, OPRM1 (mu opioid receptor 1 or MOR-1). MORs are abundantly expressed by basket cells and other inhibitory interneurons of CA1...
  24. pmc Receptor heterodimerization leads to a switch in signaling: beta-arrestin2-mediated ERK activation by mu-delta opioid receptor heterodimers
    Raphael Rozenfeld
    Department of Pharmacology and Biological Chemistry, Mt Sinai School of Medicine, One Gustave L Levy Pl, New York, NY 10029, USA
    FASEB J 21:2455-65. 2007
    ..Taken together, these results show for the first time that muOR-deltaOR heterodimers, by differentially recruiting beta-arrestin, modulate the spatio-temporal dynamics of opioid receptor signaling...
  25. ncbi Endogenous opioids: role in prostaglandin-dependent and -independent fever
    Daniel Fraga
    Departamento de Farmacologia, Setor de Ciencias Biologicas, Universidade Federal do Parana, CEP 81540 970, Curitiba, Parana, Brazil
    Am J Physiol Regul Integr Comp Physiol 294:R411-20. 2008
    ..In conclusion, our results suggest that LPS and endogenous pyrogens (except IL-1beta and prostaglandins) recruit the opioid system to cause a mu-receptor-mediated fever...
  26. doi Inhibitory action of endomorphin-1 on sensory neuropeptide release and neurogenic inflammation in rats and mice
    R Borzsei
    Department of Pharmacology and Pharmacotherapy, Faculty of Medicine, University of Pecs, H 7643, Pecs, Szigeti u 12, Hungary
    Neuroscience 152:82-8. 2008
    ..These results suggest that endomorphin-1 is able to inhibit the outflow of pro-inflammatory sensory neuropeptides. Based on this mechanism of action it is also able to effectively diminish neurogenic inflammatory responses in vivo...
  27. pmc Ovarian steroids alter mu opioid receptor trafficking in hippocampal parvalbumin GABAergic interneurons
    Annelyn Torres-Reveron
    Division of Neurobiology, Department of Neurology and Neuroscience, Weill Cornell Medical College, 407 East 61st Street, New York, NY 10065, USA
    Exp Neurol 219:319-27. 2009
    ..c.) administration. Dorsal hippocampal sections were dually immunolabeled for MOR and PARV and examined by light and electron microscopy...
  28. pmc mu-Opioid receptor stimulation in the nucleus accumbens elevates fatty tastant intake by increasing palatability and suppressing satiety signals
    Yoshihiro Katsuura
    Department of Physiology, University of Utah School of Medicine, Salt Lake City, Utah, USA
    Am J Physiol Regul Integr Comp Physiol 301:R244-54. 2011
    Infusion of a μ-opioid receptor (MOR) agonist into the nucleus accumbens (NAcc) drives voracious food intake, an effect hypothesized to occur through increased tastant palatability...
  29. pmc Immunohistochemical localization of mu opioid receptor in the marginal division with comparison to patches in the neostriatum of the rat brain
    Chuanxing Wang
    College of Biophotonics, South China Normal University, Guangzhou, GD 510631, China
    J Biomed Sci 18:34. 2011
    Mu opioid receptor (MOR), which plays key roles in analgesia and also has effects on learning and memory, was reported to distribute abundantly in the patches of the neostriatum...
  30. doi Ghrelin interacts with neuropeptide Y Y1 and opioid receptors to increase food reward
    Karolina P Skibicka
    Department of Physiology Endocrinology, Institute of Neuroscience and Physiology, the Sahlgrenska Academy at University of Gothenburg, Medicinaregatan 11, P O Box 434, SE 405 30 Gothenburg, Sweden
    Endocrinology 153:1194-205. 2012
    ..Thus, we identify central NPY and opioid signaling as the necessary mediators of food intake and reward effects of ghrelin and localize these interactions to the mesolimbic VTA...
  31. doi Electrical and manual acupuncture stimulation affect oestrous cyclicity and neuroendocrine function in an 5α-dihydrotestosterone-induced rat polycystic ovary syndrome model
    Yi Feng
    Institute of Neuroscience and Physiology, Department of Physiology, Sahlgrenska Academy, University of Gothenburg, Sweden
    Exp Physiol 97:651-62. 2012
    ..The effects of low-frequency EA may be mediated by central opioid receptors, while manual stimulation may involve regulation of steroid hormone/peptide receptors...
  32. pmc Disturbances in behavior and cortical enkephalin gene expression during the anticipation of ethanol in rats characterized as high drinkers
    Irene Morganstern
    Laboratory of Behavioral Neurobiology, The Rockefeller University, New York, NY 10065, USA
    Alcohol 46:559-68. 2012
    ..05) and the mu-opioid receptor (MOR) (p < 0...
  33. pmc Attenuation of cocaine and heroin seeking by μ-opioid receptor antagonism
    Chiara Giuliano
    Behavioral and Clinical Neuroscience Institute and Department of Psychology, University of Cambridge, Cambridge, UK
    Psychopharmacology (Berl) 227:137-47. 2013
    ..The μ-opioid receptor antagonist naltrexone (NTX) has been reported to be effective in preventing relapse to alcoholism and in reducing alcohol and cocaine craving during abstinence...
  34. pmc Synaptic connections between endomorphin 2-immunoreactive terminals and μ-opioid receptor-expressing neurons in the sacral parasympathetic nucleus of the rat
    Xiao Liang Dou
    Department of Urology, Xijing Hospital, The Fourth Military Medical University, Xi an, China
    PLoS ONE 8:e62028. 2013
    The urinary bladder is innervated by parasympathetic preganglionic neurons (PPNs) that express μ-opioid receptors (MOR) in the sacral parasympathetic nucleus (SPN) at lumbosacral segments L6-S1...
  35. doi Structure-activity relationships and discovery of a G protein biased μ opioid receptor ligand, [(3-methoxythiophen-2-yl)methyl]({2-[(9R)-9-(pyridin-2-yl)-6-oxaspiro-[4.5]decan-9-yl]ethyl})amine (TRV130), for the treatment of acute severe pain
    Xiao Tao Chen
    Trevena, Inc, 1018 West 8th Avenue, Suite A, King of Prussia, Pennsylvania 19406, United States
    J Med Chem 56:8019-31. 2013
    ..It is currently being evaluated in human clinical trials for the treatment of acute severe pain. ..
  36. pmc FK506-binding protein 12 modulates μ-opioid receptor phosphorylation and protein kinase C(ε)-dependent signaling by its direct interaction with the receptor
    Yu Qiu
    Department of Pharmacology, Institute of Medical Sciences, Shanghai Jiao Tong University School of Medicine, Shanghai, People s Republic of China Y Q, Y W, J R X, S J, Y H Y, H Z C and Department of Pharmacology, University of Minnesota, Minneapolis, Minnesota Y Q, W Z, E H, H H L, P Y L
    Mol Pharmacol 85:37-49. 2014
    ..Thus, the association of FKBP12 with OPRM1 attenuates the phosphorylation of the receptor and triggers the recruitment and activation of PKCε. ..
  37. doi Connections between EM2- and SP-containing terminals and GABAergic neurons in the mouse spinal dorsal horn
    Dao Shu Luo
    Department of Anatomy, Histology and Embryology, Basic Medical College, Fujian Medical University, Fuzhou, 350004, China
    Neurol Sci 35:1421-7. 2014
    ..These results suggest that the interactions between EM2- and SP-containing terminals and GABAergic interneurons in the lamina II influence pain transmission and modulation in the spinal dorsal horn...
  38. doi μ-δ opioid receptor heteromer-specific signaling in the striatum and hippocampus
    Noufissa Kabli
    Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, 250 College Street, Toronto, Ontario M5T1R8, Canada Department of Pharmacology, University of Toronto, Medical Sciences Building RM 4358, 1 King s College Circle, Toronto, Ontario M5S1A8, Canada
    Biochem Biophys Res Commun 450:906-11. 2014
    ..Our data demonstrate that μ-δ heteromer signaling does not desensitize and is regulated differently from μ- and δ-receptor signaling following prolonged morphine treatment. ..
  39. doi Cardiovascular responses to microinjections of endomorphin-2 into the nucleus of the solitary tract are attenuated in the spontaneously hypertensive rat
    Tetsuya Kawabe
    Center for Educational Research and Development, Wakayama Medical University, Wakayama, Japan
    Clin Exp Hypertens 37:197-206. 2015
    ..These results demonstrate that attenuation of EM2-induced responses in the mNTS of SHR may contribute to the excitatory responses elicited by ARCN stimulation in SHR...
  40. doi μ-Opioid receptor attenuates Aβ oligomers-induced neurotoxicity through mTOR signaling
    Yan Wang
    Department of Pharmacology, Institute of Medical Sciences, Shanghai Jiao Tong University School of Medicine, Shanghai, China Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    CNS Neurosci Ther 21:8-14. 2015
    ..However, it is not clear whether OPRM1 protects neurons against β-amyloid peptide (Aβ) neurotoxicity through mTOR signaling...
  41. pmc Knockdown of ventral tegmental area mu-opioid receptors in rats prevents effects of social defeat stress: implications for amphetamine cross-sensitization, social avoidance, weight regulation and expression of brain-derived neurotrophic factor
    Caitlin E Johnston
    Department of Basic Medical Sciences, University of Arizona College of Medicine, Phoenix, AZ, USA
    Neuropharmacology 89:325-34. 2015
    ..Moreover, social stress upregulates VTA mu-opioid receptor (MOR) mRNA...
  42. pmc Exposure to opiates in female adolescents alters mu opiate receptor expression and increases the rewarding effects of morphine in future offspring
    Fair M Vassoler
    Department of Biomedical Sciences, Cummings School of Veterinary Medicine, Tufts University, Peabody Pavilion, 200 Westborough Road, Grafton, MA 01536, USA Electronic address
    Neuropharmacology 103:112-21. 2016
    ..Results indicate that F1 females whose mothers were exposed to morphine during adolescence (Mor-F1) demonstrate significantly enhanced CPP to the lowest doses of morphine compared with Sal-F1 females...
  43. ncbi G-protein-coupled receptor signaling components localize in both sarcolemmal and intracellular caveolin-3-associated microdomains in adult cardiac myocytes
    Brian P Head
    Department of Pharmacology, University of California, San Diego, La Jolla, California 92093 0636, USA
    J Biol Chem 280:31036-44. 2005
    ....
  44. doi Opioid μ-receptors in the rostral medullary raphe modulate hypoxia-induced hyperpnea in unanesthetized rats
    M B Dias
    Department of Physiological Sciences, Federal University of Goias, Goiania, GO, Brazil
    Acta Physiol (Oxf) 204:435-42. 2012
    ..As opioid μ-receptors have been found in the MR, we studied the putative role of opioid μ-receptors in the rostral MR (rMR) region on ventilation in normal and 7% hypoxic conditions...
  45. pmc Distribution of CB1 cannabinoid receptors and their relationship with mu-opioid receptors in the rat periaqueductal gray
    A R Wilson-Poe
    Department of Neuroscience, Washington State University, 14204 NE Salmon Creek Avenue, Vancouver, WA 98686, USA
    Neuroscience 213:191-200. 2012
    ..These results indicate that behavioral interactions between cannabinoids and opioids may be the result of cellular adaptations within PAG neurons co-expressing CB1 and MOP receptors...
  46. doi Thioredoxin-1 expression regulated by morphine in SH-SY5Y cells
    Fu Cheng Luo
    Medical Faculty, Kunming University of Science and Technology, Kunming 650500, China
    Neurosci Lett 523:50-5. 2012
    ..These results suggest that thioredoxin-1 maybe play a role in the actions of morphine. More detailed analysis could clarify cellular and molecular mechanisms involved in the actions of morphine...
  47. pmc Activation of opioid μ-receptors, but not δ- or κ-receptors, switches pulmonary C-fiber-mediated rapid shallow breathing into an apnea in anesthetized rats
    Zhenxiong Zhang
    Pathophysiology Program, Lovelace Respiratory Research Institute, Albuquerque, NM 87108, United States
    Respir Physiol Neurobiol 183:211-7. 2012
    ..Our results suggest that activating μ-receptors is capable of turning the PCF-mediated RSB into an apnea, at least partly, via facilitating PCFs' activity and this switching effect appears independent of the released histamine...
  48. doi Regulation of μ-opioid type 1 receptors by microRNA134 in dorsal root ganglion neurons following peripheral inflammation
    J Ni
    Key Laboratory of Pain Basic Research and Clinical Therapy, Department of Neurobiology, Medical College of Soochow University, Suzhou, China
    Eur J Pain 17:313-23. 2013
    MOR1 is the main transcript of μ-opioid receptor (MOR) gene, which represents a mandatory molecule for the analgesic effects of opioids and plays an important role in the pathology of inflammatory pain...
  49. ncbi Characterization and distribution of a cloned rat mu-opioid receptor
    J R Bunzow
    Vollum Institute for Advanced Biomedical Research, Oregon Health Sciences University, Portland 97201
    J Neurochem 64:14-24. 1995
    ..The highest levels of mu-receptor mRNA were detected in the thalamus, medial habenula, and the caudate putamen; however, significant hybridization was also observed in many other brain regions, including the hypothalamus...
  50. ncbi Stereoselective interaction of ketamine with recombinant mu, kappa, and delta opioid receptors expressed in Chinese hamster ovary cells
    K Hirota
    University Department of Anaesthesia, Leicester Royal Infirmary, United Kingdom
    Anesthesiology 90:174-82. 1999
    ....
  51. ncbi Regulation of mu-opioid receptor gene transcription by interleukin-4 and influence of an allelic variation within a STAT6 transcription factor binding site
    J Kraus
    Department of Pharmacology, University of Magdeburg, 44 Leipziger Strasse, 39120 Magdeburg, Germany
    J Biol Chem 276:43901-8. 2001
    ..These findings provide a molecular basis for understanding bidirectional interactions between the opioid system and the immune system...
  52. ncbi Mu opioid receptors are in discrete hippocampal interneuron subpopulations
    Carrie T Drake
    Department of Neurology and Neuroscience, Weill Medical College of Cornell University, New York, New York 10021, USA
    Hippocampus 12:119-36. 2002
    In the rat hippocampal formation, application of mu opioid receptor (MOR) agonists disinhibits principal cells, promoting excitation-dependent processes such as epileptogenesis and long-term potentiation...
  53. ncbi Mu opioid receptors and analgesia at the site of a peripheral nerve injury
    Wayne Truong
    Department of Clinical Neurosciences and the Neuroscience Research Group, University of Calgary, Calgary, Alberta, Canada
    Ann Neurol 53:366-75. 2003
    ..Equimolar local DAGO ([D-Ala2, N-Me-Phe4, Gly5-(ol)] enkephalin), a selective MOR ligand, provided similar analgesia. Local morphine also attenuated mechanical allodynia...
  54. ncbi Spinal pharmacology of antinociception produced by microinjection of mu or delta opioid receptor agonists in the ventromedial medulla of the rat
    R W Hurley
    Department of Anesthesia and Critical Care, University of Chicago, Chicago, IL 60637, USA
    Neuroscience 118:789-96. 2003
    ..Taken together, these results support the hypothesis that the antinociception produced by activation of delta(1), delta(2) or mu opioid receptors in the rostral ventromedial medulla is mediated by different neural substrates...
  55. ncbi The presence of opioid receptors in rat inner ear
    Nopporn Jongkamonwiwat
    Neuro Behavioural Biology Center, Institute of Science and Technology for Research and Development, Mahidol University, 73170 Nakornpathom, Thailand
    Hear Res 181:85-93. 2003
    ..The aim of the present study was therefore to identify and localize the mu (MOR), delta (DOR) and kappa (KOR) opioid receptor subtypes within the rat cochlea...
  56. ncbi Expression and G-protein coupling of mu-opioid receptors in the spinal cord and dorsal root ganglia of polyarthritic rats
    S Ballet
    INSERM U288, NeuroPsychoPharmacologie Moléculaire, Cellulaire et Fonctionnelle, Faculté de Médecine Pitié Salpêtrière, 91, Boulevard de l Hopital, 75634 Paris 13, France
    Neuropeptides 37:211-9. 2003
    ..In contrast, axonal transport of mu-opioid receptors in the peripheral portion of these fibres probably accounts for the increased receptor density in inflamed tissues already reported in the literature...
  57. ncbi Neuronal types expressing mu- and delta-opioid receptor mRNA in the rat hippocampal formation
    Ralf K Stumm
    Department of Pharmacology and Toxicology, Otto von Guericke University, Leipziger Strasse 44, 39120 Magdeburg, Germany
    J Comp Neurol 469:107-18. 2004
    ..neuromodulatory role of opioids in rat hippocampal circuits, we analyzed types of micro- and delta-opioid receptor (MOR, DOR)-expressing hippocampal neurons...
  58. ncbi Expression of MOR1C-like mu-opioid receptor mRNA in rats
    Stephen A Schnell
    Department of Neuroscience, University of Minnesota, Minneapolis, Minnesota 55405, USA
    J Comp Neurol 473:213-32. 2004
    ..sequencing of this cDNA fragment showed it to be homologous to that of the mu-opioid receptor splice variant MOR(1C) from mice. We used the cDNA to make an RNA probe for a ribonuclease protection assay (RPA)...
  59. ncbi Neuron-restrictive silencer factor (NRSF) functions as a repressor in neuronal cells to regulate the mu opioid receptor gene
    Chun Sung Kim
    Department of Pharmacology, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA
    J Biol Chem 279:46464-73. 2004
    The mu opioid receptor (MOR) is expressed in the central nervous system and specific cell lines with varying expression levels perhaps playing important roles...
  60. ncbi The functional expression of mu opioid receptors on sensory neurons is developmentally regulated; morphine analgesia is less selective in the neonate
    Reema Nandi
    Department of Anatomy and Developmental Biology, University College London, Gower Street, London WC1E6BT, UK
    Pain 111:38-50. 2004
    ..In this study we have investigated the postnatal regulation of Mu opioid receptor (MOR) function in both rat lumbar dorsal root ganglion (DRG) cultures and behavioural mechanical and thermal reflex ..
  61. ncbi Chronic sucrose ingestion enhances mu-opioid discriminative stimulus effects
    David C Jewett
    Department of Psychology, University of Wisconsin Eau Claire, Eau Claire, WI 54702, USA
    Brain Res 1050:48-52. 2005
    ..These findings suggest chronic sucrose consumption results in changes in opioid-system function that modulates the effects of exogenously administered opioids...
  62. ncbi Functional and ultrastructural neuroanatomy of interactive intratectal/tectonigral mesencephalic opioid inhibitory links and nigrotectal GABAergic pathways: involvement of GABAA and mu1-opioid receptors in the modulation of panic-like reactions elicited b
    S J Ribeiro
    Laboratory of Neuroanatomy and Neuropsychobiology, Department of Pharmacology, School of Medicine of Ribeirão Preto of the University of São Paulo FMRP USP, Avenue of Bandeirantes, 3900, Ribeirao Preto SP 14049 900, Brazil
    J Chem Neuroanat 30:184-200. 2005
    ....
  63. ncbi Expression of the mu-opioid receptor is induced in dentate gyrus granule cells after focal cerebrocortical ischaemia and stimulation of entorhinal afferents
    Ralf Stumm
    Department of Pharmacology and Toxicology, Otto von Guericke University, 39120 Magdeburg, Germany
    Eur J Neurosci 22:1032-44. 2005
    ..permanent focal ischaemia and electrical afferent stimulation influence the expression of the mu-opioid receptor (MOR) in the rat hippocampus...
  64. ncbi Redistribution of mu-opioid receptors in C1 adrenergic neurons following chronic administration of morphine
    Carrie T Drake
    Department of Neurology and Neuroscience, Weill Medical College of Cornell University, 411 East 69th Street, New York, NY 10021, USA
    Exp Neurol 196:365-72. 2005
    ..C1 neurons that contain mu-opioid receptors (MORs) are hyperpolarized by MOR activation and are activated during morphine withdrawal...
  65. ncbi Endomorphin1 and endomorphin2, endogenous potent inhibitors of electrical field stimulation (EFS)-induced cholinergic contractions of rat isolated bronchus
    Ye Yu
    Department of Biochemistry and Molecular Biology, School of Life Science, Lanzhou University, 222 Tian Shui South Road, Lanzhou 730000, PR China
    Peptides 27:1846-51. 2006
    ..study, we determined whether endomorphin1 (EM1) and endomorphin2 (EM2), selective endogenous mu-opioid receptor (MOR) agonists, inhibited the response to EFS in rat isolated bronchus in a concentration- and frequency-dependent ..
  66. ncbi Loss of spinal mu-opioid receptor is associated with mechanical allodynia in a rat model of peripheral neuropathy
    Seung Keun Back
    Medical Science Research Center and Department of Physiology, Korea University College of Medicine, 126 1 Anam dong 5 ga, Seongbuk Ku, Seoul 136 705, Republic of Korea
    Pain 123:117-26. 2006
    ..These results suggest that the loss of spinal mu-opioid receptors following peripheral nerve injury is related to mechanical allodynia...
  67. ncbi Increased body weight in mice lacking mu-opioid receptors
    Wenhua Han
    Division of Psychobiology, Tokyo Institute of Psychiatry, Kamikitazawa, Tokyo, Japan
    Neuroreport 17:941-4. 2006
    ..Our results suggest that the up-regulated expression of neuropeptide Y mRNA might contribute to the increased weights of adult mu-opioid receptor knockout mice...
  68. ncbi Differential regional effects of methadone maintenance compared to heroin dependence on mu-opioid receptor desensitization in rat brain
    Thomas J Martin
    Center for the Neurobiological Investigation of Drug Abuse, Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Synapse 61:176-84. 2007
    ..Elucidating the mechanisms by which methadone induces differential desensitization of mu-opioid receptors across brain regions compared with heroin could provide insights to improve the pharmacotherapy of heroin addiction...
  69. ncbi Roles of different subtypes of opioid receptors in mediating the ventrolateral orbital cortex opioid-induced inhibition of mirror-neuropathic pain in the rat
    M Zhao
    Department of Physiology and Pathophysiology, Key Laboratory of Environment and Genes Related to Diseases, Ministry of Education, Xi an Jiaotong University School of Medicine, Yanta Road West 76, Xi an, Shaanxi 710061, PR China
    Neuroscience 144:1486-94. 2007
    ..These results suggest that the VLO is involved in opioid-induced inhibition of the MNP and the effect is mediated by mu- (but not delta- and kappa-) opioid receptors...
  70. ncbi Impact of 6-hydroxydopamine lesions and cocaine exposure on mu-opioid receptor expression and regulation of cholinergic transmission in the limbic-prefrontal territory of the rat dorsal striatum
    Maritza Jabourian
    INSERM U667, College de France, 11 place Marcelin Berthelot, F 75231 Paris Cedex 05, France
    Eur J Neurosci 25:1546-56. 2007
    ..degeneration of striatal dopaminergic innervation or cocaine (acute and chronic) exposure on (i) MOR expression in both cholinergic interneurons and output neurons of striosomes, and (ii) the direct and indirect ..
  71. ncbi Endomorphin-2-immunoreactive fibers selectively appose serotonergic neuronal somata in the rostral ventral medial medulla
    Ming Gu
    Department of Neuroscience, University of Minnesota, Minneapolis, Minnesota 55455, USA
    J Comp Neurol 502:701-13. 2007
    ..1984] Brain Res 298:329-337) and that spinally projecting serotonergic RVM neurons express mu-opioid receptors (MOR) (Kalyuzhny et al. [1996] J Neurosci 16:6490-6503; Wang and Wessendorf [1999] J Comp Neurol 404:183-196)...
  72. ncbi Preprodynorphin mediates locomotion and D2 dopamine and mu-opioid receptor changes induced by chronic 'binge' cocaine administration
    A Bailey
    School of Biomedical and Molecular Sciences, University of Surrey, Guildford, UK
    J Neurochem 102:1817-30. 2007
    ....
  73. ncbi [Expression of beta-endorphin and micro-opioid receptor during wound healing process in rat with deep partial-thickness scald]
    Biao Cheng
    Department of Plastic Surgery, Guangzhou General Hospital of Guangzhou Military Command, Guangzhou 510010, PR China
    Zhonghua Shao Shang Za Zhi 23:36-9. 2007
    To observe the expression of beta-endorphin and micro-opioid receptor (MOR) during wound healing process in rat with deep partial-thickness scald.
  74. pmc Brain region-specific N-glycosylation and lipid rafts association of the rat mu opioid receptor
    Peng Huang
    Department of Pharmacology, Center for Substance Abuse Research, Temple University School of Medicine, Philadelphia, PA 19140, USA
    Biochem Biophys Res Commun 365:82-8. 2008
    The mu opioid receptor (MOR) in the rat and mouse caudate putamen (CPu) and thalamus was demonstrated as diffuse and broad bands by Western blot with a polyclonal antibody against a C-terminal peptide of MOR, which were absent in the ..
  75. pmc Ethanol dually modulates GABAergic synaptic transmission onto dopaminergic neurons in ventral tegmental area: role of mu-opioid receptors
    C Xiao
    Department of Anesthesiology, Physiology and Pharmacology, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, 185 South Orange Avenue, Newark, NJ 07103, USA
    Neuroscience 153:240-8. 2008
    ..This dual modulation of GABAergic transmission by ethanol may be an important mechanism underlying alcohol addiction...
  76. doi Postsynaptic mu-opioid receptor response in the median preoptic nucleus is altered by a systemic sodium challenge in rats
    Mélaine Henry
    Centre de Recherche du CHUL CHUQ, Unité de Neurosciences et Université Laval, Quebec, QC, Canada G1V 4G2
    Eur J Neurosci 27:1197-209. 2008
    ..Such network plasticity might be related to the avid salt ingestion triggered by repeated Na(+) depletion...
  77. doi Phosphorylation state of mu-opioid receptor determines the alternative recycling of receptor via Rab4 or Rab11 pathway
    Feifei Wang
    Pharmacology Research Center, Fudan University, 138 Yi Xue Yuan Road, Shanghai 200032, People s Republic of China
    Mol Endocrinol 22:1881-92. 2008
    ..state in regulation of agonist-induced internalization and intracellular trafficking of mu-opioid receptor (MOR)...
  78. doi Opioid activation in the lateral parabrachial nucleus induces hypertonic sodium intake
    L B de Oliveira
    Department of Biological Sciences, DECBI NUPEB, Federal University of Ouro Preto, Ouro Preto, MG, Brazil
    Neuroscience 155:350-8. 2008
    ..The results suggest that deactivation of inhibitory mechanisms by opioid receptor activation in the LPBN releases sodium intake if excitatory signals were activated (sodium depletion) or not...
  79. doi Participation of mu-opioid, GABA(B), and NK1 receptors of major pain control medullary areas in pathways targeting the rat spinal cord: implications for descending modulation of nociceptive transmission
    Marta Pinto
    Institute of Histology and Embryology, Faculdade de Medicina, Universidade do Porto, 4200 319 Porto, Portugal
    J Comp Neurol 510:175-87. 2008
    ..We analyzed the expression of mu-opioid (MOR), gamma-aminobutyric acid GABA(B), and NK1 receptors in spinally projecting neurons of major medullary pain control ..
  80. pmc A naloxonazine sensitive (mu1 receptor) mechanism in the parabrachial nucleus modulates eating
    Nayla N Chaijale
    Department of Pharmacology and Physiology, Drexel University College of Medicine, Philadelphia, PA 19102, USA
    Brain Res 1240:111-8. 2008
    ..In conclusion, this study demonstrates that the mu(1) opioid receptor subtype is present in the parabrachial nucleus of the pons and that these receptors serve to modulate feeding in rats...
  81. pmc Role of mu- and delta-opioid receptors in the nucleus accumbens in cocaine-seeking behavior
    Diana Simmons
    Department of Psychiatry and the Neuroscience Graduate Program, The Seay Center for Basic and Applied Research in Psychiatric Illness, UT Southwestern Medical Center, Dallas, Texas, USA
    Neuropsychopharmacology 34:1946-57. 2009
    ..paradigm in rats that self-administer cocaine, we found that NAc infusions of the mu-opioid receptor (MOR) agonist DAMGO moderately reinstated responding on the cocaine-paired lever at low doses (1.0-3...
  82. pmc Acute inflammation induces segmental, bilateral, supraspinally mediated opioid release in the rat spinal cord, as measured by mu-opioid receptor internalization
    W Chen
    Center for the Neurobiology of Stress, Division of Digestive Diseases, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Neuroscience 161:157-72. 2009
    ..was to measure opioid release in the spinal cord during acute and long-term inflammation using mu-opioid receptor (MOR) internalization...
  83. doi Regulator of G protein signaling 4 confers selectivity to specific G proteins to modulate mu- and delta-opioid receptor signaling
    Leonidas J Leontiadis
    Laboratory of Cellular Signaling and Molecular Pharmacology, Institute of Biology, National Center for Scientific Research Demokritos, Ag Paraskevi Attikis, Athens, Greece
    Cell Signal 21:1218-28. 2009
    ..Our findings demonstrate that RGS4 plays a key role in G protein coupling selectivity and signaling of the mu- and delta-OmicronRs...
  84. doi Endomorphin-1, effects on male sexual behavior
    Leticia Parra-Gámez
    Facultad de Medicina, Universidad Nacional Autonoma de Mexico, Ciudad Universitaria, CP 04510, Mexico
    Physiol Behav 97:98-101. 2009
    ....
  85. doi Role of preoptic opioid receptors in the body temperature reduction during hypoxia
    Carolina da Silveira Scarpellini
    Department of Animal Morphology and Physiology, College of Agricultural and Veterinarian Sciences, Sao Paulo State University, Jaboticabal, SP, 14884 900, Brazil
    Brain Res 1286:66-74. 2009
    ..Our results indicate the kappa-opioid receptor in the AVPO is important for the reduction of Tb during hypoxia while the mu and delta receptors are involved in the increase of Tb during normoxia post-hypoxia...
  86. pmc Reduced emotional and corticosterone responses to stress in mu-opioid receptor knockout mice
    Soichiro Ide
    Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060 0812, Japan
    Neuropharmacology 58:241-7. 2010
    ..These results suggest that MOPs play an important facilitatory role in emotional responses to stress, including anxiety- and depression-like behavior and corticosterone levels...
  87. doi ADP-ribosylation factor 6 regulates mu-opioid receptor trafficking and signaling via activation of phospholipase D2
    Marija Rankovic
    Department of Pharmacology and Toxicology, Otto von Guericke University, Leipziger Strasse 44, 39120 Magdeburg, Germany
    Cell Signal 21:1784-93. 2009
    ..Together, these results provide evidence that ARF6 protein regulates MOPr trafficking and signaling via PLD2 activation and hence affects the development of opioid receptor desensitization and tolerance...
  88. doi Ultra-low dose naloxone restores the antinociceptive effect of morphine in pertussis toxin-treated rats by reversing the coupling of mu-opioid receptors from Gs-protein to coupling to Gi-protein
    R Y Tsai
    Department of Anesthesiology, Tri Service General Hospital and National Defense Medical Center, Taipei, Taiwan
    Neuroscience 164:435-43. 2009
    ..We suggest that ultra-low dose naloxone might be clinically valuable in pain management...
  89. pmc GRIN1 regulates micro-opioid receptor activities by tethering the receptor and G protein in the lipid raft
    Xin Ge
    Department of Pharmacology, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA
    J Biol Chem 284:36521-34. 2009
    The lipid raft location of mu-opioid receptor (MOR) determines the receptor activities. However, the manner in which MOR is anchored within the lipid rafts is undetermined...
  90. pmc CB1 receptors modulate the intake of a sweetened-fat diet in response to μ-opioid receptor stimulation of the nucleus accumbens
    Mary Jane Skelly
    Department of Psychology, Wake Forest University, Winston Salem, NC 27109, USA
    Pharmacol Biochem Behav 97:144-51. 2010
    ..These data suggest an important modulatory role for cannabinoid receptors in the expression of feeding behaviors in response to mu-opioid receptor activation of the nucleus accumbens shell...
  91. doi Plasticity of opioid receptors in the female periaqueductal gray: multiparity-induced increase in the activity of genes encoding for mu and kappa receptors and a post-translational decrease in delta receptor expression
    Elizabeth Teodorov
    Centro de Matemática, Computação e Cognição, Universidade Federal do ABC, Av Prof Dr Orlando Marques de Paiva 87, CEP 05508 900, Sao Paulo, Brazil
    J Mol Neurosci 43:175-81. 2011
    ..and δ-opioid receptor (Oprm1, Oprk1, and Oprd1 respectively) gene activity and μ, κ and δ protein expression (MOR, KOR and DOR respectively) in the PAG of the female rats...
  92. pmc The role of N53Q mutation on the rat mu-opioid receptor function
    A Rostami
    Department of Physiology and Pharmacology, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran
    J Biomol Tech 21:92-6. 2010
    ..The expression of the transfected plasmids was confirmed. Therefore, based on these results, it seems that glycosylation at the N53 site of the rat mu-opioid receptor does not influence the function of this receptor significantly...
  93. pmc Disruption of morphine-conditioned place preference by a delta2-opioid receptor antagonist: study of mu-opioid and delta-opioid receptor expression at the synapse
    Sophie K Billa
    Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, TX, USA
    Eur J Neurosci 32:625-31. 2010
    ..Overall, these results suggest that modulation of the delta-opioid receptor expression and its synaptic localization may constitute a viable therapeutic approach to disrupt morphine-induced conditioned responses...
  94. pmc Identification and characterization of seven new exon 11-associated splice variants of the rat μ opioid receptor gene, OPRM1
    Jin Xu
    Department of Neurology and Program in Molecular Pharmacology and Chemistry, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Mol Pain 7:9. 2011
    ..We now have examined 5' splicing in the rat...
  95. pmc Chronic ethanol consumption in rats produces opioid antinociceptive tolerance through inhibition of mu opioid receptor endocytosis
    Li He
    Ernest Gallo Clinic and Research Center, University of California, Emeryville, California, United States of America
    PLoS ONE 6:e19372. 2011
    It is well known that the mu-opioid receptor (MOR) plays an important role in the rewarding properties of ethanol. However, it is less clear how chronic ethanol consumption affects MOR signaling...
  96. ncbi Endogenous CART peptide regulates mu opioid and serotonin 5-HT(2A) receptors
    Richard B Rothman
    Clinical Psychopharmacology Section, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, PO Box 5180, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
    Peptides 24:413-7. 2003
    ..The results demonstrated that anti-CART peptide IgG up-regulates mu and 5-HT(2A) receptor in the hippocampus and caudate We conclude that CART peptides in the cerebrospinal fluid may exert regulatory effects in the brain...
  97. ncbi A role for the distal carboxyl tails in generating the novel pharmacology and G protein activation profile of mu and delta opioid receptor hetero-oligomers
    Theresa Fan
    The Centre for Addiction and Mental Health, Ontario M5T 1R8, Canada
    J Biol Chem 280:38478-88. 2005
    ....
  98. ncbi Effects of prenatal cocaine, morphine, or both on postnatal opioid (mu) receptor development
    Rama Bhat
    Department of Pediatrics, M C 856, University of Illinois at Chicago, 840 S Wood St, Chicago, IL 60612, USA
    Life Sci 78:1478-82. 2006
    ..In addition, there was also a significant increase in MOR mRNA in both the morphine alone and combination groups...
  99. ncbi Gbetagamma that interacts with adenylyl cyclase in opioid tolerance originates from a Gs protein
    Hoau Yan Wang
    Department of Physiology and Pharmacology, City University of New York Medical School, 138th Street and Convent Avenue, New York, New York 10031, USA
    J Neurobiol 66:1302-10. 2006
    We previously demonstrated that chronic morphine induces a change in G protein coupling by the mu opioid receptor (MOR) from Gi/o to Gs, concurrent with the instatement of an interaction between Gbetagamma and adenylyl cyclase types II ..
  100. ncbi Nerve growth factor governs the enhanced ability of opioids to suppress inflammatory pain
    Shaaban A Mousa
    Klinik fur Anaesthesiologie und operative Intensivmedizin, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Berlin, Germany
    Brain 130:502-13. 2007
    ..Peripheral opioid antinociception is dependent on sensory neuron mu opioid receptor (MOR) expression, coupling and efficacy...
  101. pmc Ultrastructural evidence for co-localization of corticotropin-releasing factor receptor and mu-opioid receptor in the rat nucleus locus coeruleus
    Beverly A S Reyes
    Thomas Jefferson University, Department of Neurosurgery, Farber Institute for Neurosciences, Philadelphia, PA 19107, United States
    Neurosci Lett 413:216-21. 2007
    ..These data provide ultrastructural evidence that CRFr and muOR are co-localized in LC neurons, a cellular substrate that may underlie opiate-induced sensitization of brain noradrenergic neurons to CRF...

Research Grants5

  1. MOP Receptor Effects on the Hippocampal CA1 Network
    ADAM MCQUISTON; Fiscal Year: 2008
    ..The results from these studies will provide important information regarding MOP receptor-induced changes in network activity and may possibly lead to the development of treatments for opioid addiction. ..
  2. K-OPIOID SYSTEMS--SEX AND PREGNANCY LINKED DIFFERENCES
    CARRIE DRAKE; Fiscal Year: 2002
    ..The results of these studies will be relevant to understanding gender differences in analgesia, and may aid in the development of analgesic drugs and their targeting to appropriate patient populations. ..
  3. Opiate's Effects on the Inflammation and Cytotoxicity in HIV-1 Transgenic Rat
    SULIE CHANG; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  4. Role of the Amygdala in Opioid Self-administration in Rats with Chronic Pain.
    Thomas Martin; Fiscal Year: 2009
    ....